Relevant bibliographies by topics / Endpoints

Academic literature on the topic 'Endpoints'

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Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Endpoints"

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Banerjee, Buddhananda, and Atanu Biswas. "True endpoint reduction by surrogate endpoints." Communications in Statistics - Simulation and Computation 46, no. 8 (May 27, 2016): 6645–53. http://dx.doi.org/10.1080/03610918.2016.1171350.

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Ferreira-González, Ignacio, and Gaietà Permanyer-Miralda. "Are composite endpoints multilevel endpoints?" Journal of Clinical Epidemiology 61, no. 2 (February 2008): 199–201. http://dx.doi.org/10.1016/j.jclinepi.2007.10.002.

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Hahn, Andreas, Andreas Podbielski, Markus M. Heimesaat, Hagen Frickmann, and Philipp Warnke. "Binary surrogate endpoints in clinical trials from the perspective of case definitions." European Journal of Microbiology and Immunology 11, no. 1 (March 30, 2021): 18–22. http://dx.doi.org/10.1556/1886.2020.00031.

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AbstractIntroductionSurrogate endpoints are widely used in clinical trials, especially in situations where the endpoint of interest is not directly observable or to avoid long trial periods. A typical example for this case is frequently found in clinical trials in oncology, where overall survival (OS) as endpoint of interest and progression free survival (PFS) as surrogate endpoint are discriminated.MethodsBased on the perspective of case definitions on surrogate endpoints, we provide a formal definition of such endpoints followed by a description of the structure of surrogate endpoints.ResultsSurrogate endpoints can be considered as case definitions for the endpoint of interest. Therefore, the performance of surrogate endpoints can be described using the classical terminology of diagnostic tests including sensitivity and specificity. Since such endpoints always focus on sensitivity with necessarily reduced specificity, efficacy estimates based on such endpoints are in general biased.ConclusionThe abovementioned has to be taken into account while interpreting the results of clinical trials and should not be ignored while planning or conducting a study.
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BOAS, R. A. "ENDPOINTS." Regional Anesthesia and Pain Medicine 23, Sup 1 (May 1998): 116. http://dx.doi.org/10.1097/00115550-199823031-00116.

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Kuller, Lewis H. "Clinical trials: surrogate endpoints or hard endpoints?" American Journal of Cardiology 88, no. 2 (July 2001): 59–61. http://dx.doi.org/10.1016/s0002-9149(01)01786-6.

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Dowsett, M. "Molecular endpoints." European Journal of Cancer 38, no. 11 (March 2002): S129. http://dx.doi.org/10.1016/s0959-8049(02)80418-x.

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ZARET, B. "Soft endpoints." Journal of Nuclear Cardiology 5, no. 3 (June 1998): 243–44. http://dx.doi.org/10.1016/s1071-3581(98)90124-6.

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Conti, C. Richard. "Clinical endpoints." Clinical Cardiology 25, no. 7 (July 2002): 311–12. http://dx.doi.org/10.1002/clc.4950250702.

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Redmond, J. M. T., and M. J. McKenna. "Neuropathy endpoints." Neurology 46, no. 4 (April 1, 1996): 1193. http://dx.doi.org/10.1212/wnl.46.4.1193.

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Ellenberg, SS. "Surrogate endpoints." British Journal of Cancer 68, no. 3 (September 1993): 457–59. http://dx.doi.org/10.1038/bjc.1993.369.

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Dissertations / Theses on the topic "Endpoints"

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Weaver, Jean M. "Molecular pharmacodynamic endpoints /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945320761452.

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Liu, Yi. "Testing for Efficacy for Primary and Secondary Endpoints by Partitioning Decision Paths." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259598621.

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Izadinia, Vafa Dario. "Fingerprinting Encrypted Tunnel Endpoints." Diss., University of Pretoria, 2005. http://hdl.handle.net/2263/25351.

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Operating System fingerprinting is a reconnaissance method used by Whitehats and Blackhats alike. Current techniques for fingerprinting do not take into account tunneling protocols, such as IPSec, SSL/TLS, and SSH, which effectively `wrap` network traffic in a ciphertext mantle, thus potentially rendering passive monitoring ineffectual. Whether encryption makes VPN tunnel endpoints immune to fingerprinting, or yields the encrypted contents of the VPN tunnel entirely indistinguishable, is a topic that has received modest coverage in academic literature. This study addresses these question by targeting two tunnelling protocols: IPSec and SSL/TLS. A new fingerprinting methodology is presented, several fingerprinting discriminants are identified, and test results are set forth, showing that endpoint identities can be uncovered, and that some of the contents of encrypted VPN tunnels can in fact be discerned.
Dissertation (MSc (Computer Science))--University of Pretoria, 2005.
Computer Science
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Feng, Chunyao Seaman John Weldon. "Bayesian evaluation of surrogate endpoints." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4187.

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Nordman, Ina IC Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Surrogate endpoints of survival in metastatic carcinoma." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/42791.

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In most randomised controlled trials (RCTs), a large number of patients need to be followed over many years, for the clinical benefit of the drug to be accurately quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship between surrogate endpoints and OS in metastatic colorectal cancer (CRC), advanced non-small cell lung cancer (NSCLC) and metastatic breast cancer (MBC). A review of the literature identified 144 RCTs in metastatic CRC, 189 in advanced NSCLC and 133 in MBC. The publications were generally of poor quality with incomplete reporting on many key variables, making comparisons between studies difficult. The introduction of the CONSORT statement was associated with improvements in the quality of reporting. For CRC (337 arms), NSCLC (429 arms) and MBC (290 arms) there were strong relationships between OS and progression free survival (PFS), time to progression (TTP), disease control rate (DCR), response rate (RR) and partial response (PR). Correlation was also demonstrated between OS and complete response (CR) in CRC and duration of response (DOR) in MBC. However, while strong relationships were found, the proportion of variance explained by the models was small. Prediction bands constructed to determine the surrogate threshold effect size indicated that large improvements in the surrogate endpoints were needed to predict overall survival gains. PFS and TTP showed the most promise as surrogates. The gain in PFS and TTP required to predict a significant gain in overall survival was between 1.2 and 7.0 months and 1.8 and 7.7 months respectively, depending on trial size and tumour type. DCR was a better potential predictor of OS than RR. The results of this study could be used to design future clinical trials with particular reference to the selection of surrogate endpoint and trial size.
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Studer, Ahren M. "Verifying Physical Endpoints to Secure Digital Systems." Research Showcase @ CMU, 2011. http://repository.cmu.edu/dissertations/77.

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The proliferation of electronic devices supporting sensing, actuation, and wireless communication enables the monitoring and/or control of a variety of physical systems with digital communication. Such “cyber physical systems” blur the boundaries of the digital and physical worlds, where correct information about the physical world is needed for the correct operation of the digital system. Often in these systems the physical source or destination of information is as important as the information itself. However, the omni-directional and invisible nature of wireless communication makes it difficult to determine communication endpoints. This allows a malicious party to intercept wireless messages or pose as other entities in the system. As such, these systems require new protocols to associate the endpoints of digital communication with physical entities. Traditional security approaches that associate cryptographic keys with names can help verify endpoints in static systems where a string accurately describes the role of a device. In other systems, the role of a device depends on its physical properties, such as location, which change over time. This dynamic nature implies that identification of an endpoint based on a static name is insufficient. Instead, we can leverage devices’ sensing and actuation capabilities to verify the physical properties and determine the physical endpoints of communication. We investigate three different scenarios where the physical source and/or destination is important and propose endpoint verification techniques: verifying the physical endpoints during an exchange between two smartphones, verifying the receiver of information is in a physical space to enable location-based access control, and verifying the source of information to protect Vehicle-to-Vehicle (V2V) applications. We evaluate our proposals in these systems and show that our solutions fulfill the security requirements while utilizing existing hardware. Exchanging Information Between Smartphones Shake on it (SHOT) allows users to verify the endpoints during an exchange of information between two smartphones. In our protocol, the phones use their vibrators and accelerometers to establish a human-observable communication channel. The users hold the phones together while the phones use this channel to bootstrap and verify the authenticity of an exchange that occurs over the higher-bandwidth wireless channel. Users can detect the injection of information from other devices as additional vibrations, and prevent such attacks. Our implementation of SHOT for the DROID smartphone is able to support sender and receiver verification during an exchange between two smartphones in 15 seconds on average. Location-Based Access Control We propose using location-based access control to protect sensitive files on laptops, without requiring any effort from the user to provide security. With a purely wireless electronic system, verifying that a given device is in a physical space is a challenge; either the definition of the physical space is vague (radio waves can travel beyond walls) or the solution requires expensive hardware to measure a message’s time of flight. Instead, we use infrared as a signal that walls can contain. We develop key derivation protocols that ensure only a receiver in the physical room with access to the signal can derive the key. We implement a system that uses the laptop’s webcam to record the infrared signal, derive a key, and decrypt sensitive files in less than 5 seconds. Source Verification for V2V Networks A number of V2V applications use information about nearby vehicles to prevent accidents or reduce fuel consumption. However, false information about the positioning of vehicles can cause erroneous behavior, including accidents that would not occur in the absence of V2V. As such, we need a way to verify which vehicle sent a message and that the message accurately describes the physical state of that vehicle. We propose using LED lights on vehicles to broadcast the certificate a vehicle is currently using. Receivers can use onboard cameras to film the encoding of the certificate and estimate the relative location of the vehicle. This visual channel allows a receiver to associate a physical vehicle at a known location with the cryptographic credentials used to sign a location claim. Our simulations indicate that even with a pessimistic visual channel, visual verification of V2V senders provides sufficient verification capabilities to support the relevant applications.
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Cooney, Maureen Anne Siega-Riz Anna Maria. "In utero environmental exposures and reproductive endpoints." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2433.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.
Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology." Discipline: Epidemiology; Department/School: Public Health.
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Alhabib, Nada. "Explosion of escaping endpoints of exponential maps." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001508/.

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Del, Gobbo Liana. "Magnesium biomarkers and cardiometabolic endpoints in multiethnic populations." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107839.

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Background: Magnesium (Mg) is known to exert diverse actions on cardiometabolic function; suboptimal Mg intake and status may contribute significantly to adverse metabolic and cardiovascular health. While type 2 diabetes mellitus (T2DM) is the most common cause of Mg depletion, research gaps exist regarding the potential influence of transient states of impaired glycemia, such as gestational diabetes, on Mg biomarkers in affected mothers or their offspring. Further, whether or not diabetes is an important effect modifier of associations between Mg biomarkers and cardiovascular endpoints, such as arrhythmias, is unknown. The determination of Mg status is riddled with challenges, however, and no simple, rapid and accurate test has emerged. Plasma (pMg) and serum Mg (sMg) are the most commonly used biomarkers; comparatively little is known about erythrocyte Mg (rMg) and cardiometabolic outcomes.Objectives: The main objectives of this thesis were: 1.) to determine if gestational diabetes history prospectively influences Mg concentrations or associations between Mg and glycemic variables in mothers and offspring 15-years post-partum (Montreal cohort) 2.) to examine associations between sMg, rMg and cardiovascular risk profiles in adults from two ethnically distinct, cross-sectional studies (Cree, Inuit) and evaluate the utility of rMg as a cardiovascular risk associate; and 3.) to estimate the risk of an arrhythmia associated with mortality, ventricular premature beats, across the sMg concentration gradient, and assess potential effect modification by T2DM status (Cree).Methods: Secondary data analysis was conducted on data collected from three diverse studies: 1.) Diabetic Pregnancies: Longitudinal follow-up of mother-offspring pairs (multiethnic Montreal cohort) 2.) Nituuchischaayihtitaau Aschii: A multi-community environment & health longitudinal study in Iiyiyiu Aschii (Cree survey) 3.) International Polar Year (IPY) Inuit Health Survey (Inuit survey). Associations between Mg biomarkers and endpoints were examined in multivariate linear and logistic regression models.Results: Gestational diabetes history 15-yrs prior was associated with reduced pMg in mothers (p=0.002) and elevated pMg in teenage offspring (p=0.002) relative to mother and offspring controls without gestational diabetes history. Associations between Mg status and some glycemic variables (fasting glucose, insulin, and insulin sensitivity) were stronger in mothers and offspring with gestational diabetes history than those without. In Cree adults without T2DM, sMg was inversely associated with fasting glucose (p=0.001), in addition to cardiovascular variables such as hsCRP (p=0.038) and carotid-intima media thickness (p=0.044). rMg was significantly associated with adiposity in both Cree and Inuit (p<0.001), but no associations between rMg and fasting glucose, insulin, hsCRP, blood pressure, nor carotid intima-media thickness were observed. In Cree, hypomagnesaemia (sMg <0.70mmol/L) was associated with an increased prevalence of ventricular premature beats (p<0.05). T2DM was a significant effect modifier of the association between sMg and risk of this arrhythmia (p<0.05).Conclusions: Transient states of impaired glycemia (gestational diabetes) may be associated with pMg and its associations with glycemic outcome variables in affected mothers and offspring. Unlike sMg or pMg, there is no current evidence that total rMg is significantly associated with a favourable cardiovascular risk profile or adds value to cardiometabolic risk assessment. Prevalence of ventricular premature beats is more common in Cree adults with hypomagnesaemia and T2DM. Further investigations evaluating the potential utility and predictive value of pMg and sMg as markers of cardiometabolic risk are warranted.
Contexte: Le magnésium (Mg) est connu pour exercer diverses mesures pour soutenir la fonction cardiométabolique. Bien que le diabète de type 2 (T2DM) est la cause la plus courante de l'épuisement de Mg, des lacunes dans la recherche existent concernant l'influence potentielle de diabète gestationnel sur le statut de Mg ultérieur ou les associations Mg-glycémiques des mères touchées ou de leur progéniture. De plus, si le diabète est un modificateur avec un effet des associations entre Mg et les bouts cardiovasculaires, tels que d'arrhythmias, est inconnue. La détermination du statut de Mg pose plein de défis, et aucun test simple, rapide et précis a émergé. Le plasma Mg (pMg) et le sérum Mg (sMg) restent les biomarqueurs utilisés le plus souvent; peu est connu au sujet de Mg érythrocytaire (rMg) et les résultats cardiométaboliques.Objectivifs : Les objectif de ce thèse était: 1.) De déterminer si l'histoire de diabète gestationnel influence les concentrations de Mg ou les associations entre les variables Mg et de la glycémie chez les mères et leurs enfants de 15 années post-partum (cohorte de Montréal), 2.) Etudier les associations entre le sMg, rMg et des profils de risque cardiovasculaires chez les adultes concernant deux études transversales et distincts sur le plan ethnique (Cris, Inuits) et évaluer l'utilité de rMg en tant qu'associé de risque cardiovasculaire; et 3.) Pour estimer le risque d'une arythmie, extrasystoles ventriculaires, à travers le gradient de concentration de sMg et d'évaluer l'effet potentiel de modification selon le statut du T2DM (population Crie).Méthodes: L'analyse des données secondaires a été réalisée sur des données recueillies auprès de trois études diverses: 1.) Grossesses diabétiques: Suivi longitudinal de la mère-enfants paires 2.) Nituuchischaayihtitaau Aschii: Une étude multi-communautaire et longitudinal sur l'environnement et la santé dans Iiyiyiu Aschii 3.) Songage sur la santé des Inuits: Quanuippitaa? Comment sommes-nous? Les associations entre les biomarqueurs et de paramètres de Mg ont été considérés dans la linéaire multivariée et la régression logistique. Résultats : L'histoire du diabète gestationnel de 15 ans avant a été associée à du pMg réduit de mères (p = 0,002) et le pMg élevée chez leur progéniture adolescente (p = 0,002). Les associations entre le statut de Mg et de certaines variables glycémique ont été plus prononcés chez les mères et leur progéniture avec l'histoire de diabète gestationnel. Chez les adultes Crie sans T2DM, le taux de sMg était inversement associé à une glycémie à jeûne (p = 0,001), en plus des variables cardiovasculaires telles que l'hsCRP (p = 0,038) et la carotide intima-média d'épaisseur (p = 0,044). rMg était significativement associé à l'adiposité chez les Cris et les Inuits (p <0,001), mais aucune association entre le rMg et le glucose du jeûne, d'insuline, de hsCRP, la pression sanguine, ni carotidienne épaisseur intima-média ont été observées. Chez les Cris, la hypomagnésémie (sMg <0.70mmol/L) était associée à une prévalence accrue des extrasystoles ventriculaires prématurés (p <0,05). Le diabète de type 2 était un modificateur d'effet de l'association entre le sMg et le risque de cette arythmie (p <0,05). Conclusions: Le diabète gestationnel peuvent influencer le pMg et des associations avec les variables des résultats de la glycémie chez les mères touchées et leur progéniture. Contrairement au sMg ou au pMg, il n'existe aucune preuve actuelle que le rMg totale est associée à un profil de risque cardiovasculaire favorable ou ajoute une valeur à l'évaluation du risque cardiométabolique. Prévalence d'une arythmie associée à un risque élevé de mortalité est plus fréquente chez les adultes Cris avec l'hypomagnésémie et T2DM. D'autres investigations évaluent l'utilité potentielle et la valeur prédictive de Mg extracellulaire (pMg et sMg) comme marqueurs du risque cardiométabolique sont appropriées.
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Blatchford, Patrick Judson. "Monitoring bivariate endpoints in group sequential clinical trials /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biostatistics) -- University of Colorado Denver, 2007.
Typescript. Includes bibliographical references (leaves 104-106). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Books on the topic "Endpoints"

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Bradshaw, A. D. Alternative endpoints for reclamation. Boca Raton, FL: CRC Press, 1988.

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Burzykowski, Tomasz, Geert Molenberghs, and Marc Buyse, eds. The Evaluation of Surrogate Endpoints. New York, NY: Springer New York, 2005. http://dx.doi.org/10.1007/b138566.

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Emura, Takeshi, Shigeyuki Matsui, and Virginie Rondeau. Survival Analysis with Correlated Endpoints. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3516-7.

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Rauch, Geraldine, Svenja Schüler, and Meinhard Kieser. Planning and Analyzing Clinical Trials with Composite Endpoints. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73770-6.

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Sozu, Takashi, Tomoyuki Sugimoto, Toshimitsu Hamasaki, and Scott R. Evans. Sample Size Determination in Clinical Trials with Multiple Endpoints. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22005-5.

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Clinical trials: Study design, endpoints and biomarkers, drug safety, FDA and ICH guidelines. Amsterdam: Elsevier/AP, 2012.

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Medicine), Roundtable for the Development of Drugs and Vaccines against AIDS (Institute of. Surrogate endpoints in evaluating the effectiveness of drugs against HIV infection and AIDS: September 11-12, 1989 : conference summary. Washington, D.C: National Academy Press, 1990.

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Morganroth, Joel, and E. Neil Moore, eds. Use and Approval of Antihypertensive Agents and Surrogate Endpoints for the Approval of Drugs Affecting Antiarrhythmic Heart Failure and Hypolipidemia. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1505-6.

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John, Updike. Endpoint and other poems. New York: Alfred A. Knopf, 2009.

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John, Updike. Endpoint and Other Poems. New York: Knopf Doubleday Publishing Group, 2009.

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Book chapters on the topic "Endpoints"

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Hewitt-Taylor, Jaqui. "Endpoints." In Understanding and Managing Change in Healthcare, 227–30. London: Macmillan Education UK, 2013. http://dx.doi.org/10.1007/978-1-137-02277-6_12.

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Hewitt-Taylor, Jaqui. "Endpoints." In Developing Person-centred Practice, 218–21. London: Macmillan Education UK, 2015. http://dx.doi.org/10.1007/978-1-137-39979-3_12.

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Cleophas, Ton J., and Aeilko H. Zwinderman. "Multiple Endpoints." In Machine Learning in Medicine, 29–36. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-7869-6_4.

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Ekhtiari, Seper, Ryan P. Coughlin, Nicole Simunovic, and Olufemi R. Ayeni. "Surrogate Endpoints." In Evidence-Based Surgery, 85–92. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05120-4_9.

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Sonni, Shruti, and Karen Furie. "Clinical Endpoints." In Clinical Trials in the Neurosciences, 93–97. Basel: KARGER, 2009. http://dx.doi.org/10.1159/000209481.

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Bretz, Frank, and Michael Branson. "Multiple Endpoints." In Methods and Applications of Statistics in Clinical Trials, 570–76. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118596005.ch46.

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Fleming, Thomas R., Victor DeGruttola, and David L. Demets. "Surrogate Endpoints." In Methods and Applications of Statistics in Clinical Trials, 878–86. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118596005.ch74.

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Neumayer, Leigh, and William G. Henderson. "Endpoints Committee." In Clinical Trials Design in Operative and Non Operative Invasive Procedures, 335–39. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_40.

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Shoff, William H., Catherine T. Shoff, Suzanne M. Shepherd, Jonathan L. Burstein, Calvin A. Brown, Ashita J. Tolwani, Bala Venkatesh, et al. "Resuscitation Endpoints." In Encyclopedia of Intensive Care Medicine, 1996–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_462.

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Panageas, Katherine S., and Andrea Knezevic. "Selection of Endpoints." In Textbook of Clinical Trials in Oncology, 9–26. Boca Raton, Florida : CRC Press, [2019]: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781315112084-2.

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Conference papers on the topic "Endpoints"

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Weigle, E., and A. A. Chien. "The Composite Endpoint Protocol (CEP): scalable endpoints for terabit flows." In CCGrid 2005. IEEE International Symposium on Cluster Computing and the Grid, 2005. IEEE, 2005. http://dx.doi.org/10.1109/ccgrid.2005.1558686.

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Tchakountio, Fabrice, and Ram Ramanathan. "Tracking Highly Mobile Endpoints." In the 4th ACM international workshop. New York, New York, USA: ACM Press, 2001. http://dx.doi.org/10.1145/605991.606003.

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Wellman, D. M., M. D. Freshley, M. J. Truex, and M. H. Lee. "Deep Vadose Zone Remediation: Technical and Policy Challenges, Opportunities, and Progress in Achieving Cleanup Endpoints." In ASME 2013 15th International Conference on Environmental Remediation and Radioactive Waste Management. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icem2013-96011.

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Current requirements for site remediation and closure are standards-based and are often overly conservative, costly, and in some cases, technically impractical. Use of risk-informed alternate endpoints provides a means to achieve remediation goals that are permitted by regulations and are protective of human health and the environment. Alternate endpoints enable the establishment of a path for cleanup that may include intermediate remedial milestones and transition points and/or regulatory alternatives to standards-based remediation. A framework is presented that is centered around developing and refining conceptual models in conjunction with assessing risks and potential endpoints as part of a system-based assessment that integrates site data with scientific understanding of processes that control the distribution and transport of contaminants in the subsurface and pathways to receptors. This system-based assessment and subsequent implementation of the remediation strategy with appropriate monitoring are targeted at providing a holistic approach to addressing risks to human health and the environment. This holistic approach also enables effective predictive analysis of contaminant behavior to provide defensible criteria and data for making long-term decisions. Developing and implementing an alternate endpoint-based approach for remediation and waste site closure presents a number of challenges and opportunities. Categories of these challenges include scientific and technical, regulatory, institutional, and budget and resource allocation issues. Opportunities exist for developing and implementing systems-based approaches with respect to supportive characterization, monitoring, predictive modeling, and remediation approaches.
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Cruz, Bruno Simoes, and Joao Paulo Barraca. "IMS centric communication supporting WebRTC endpoints." In 2015 20th IEEE Symposium on Computers and Communication (ISCC). IEEE, 2015. http://dx.doi.org/10.1109/iscc.2015.7405601.

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Tanase, Gabriel, Gheorghe Almasi, Hanhong Xue, and Charles Archer. "Network Endpoints for Clusters of SMPs." In 2012 24th International Symposium on Computer Architecture and High Performance Computing (SBAC-PAD). IEEE, 2012. http://dx.doi.org/10.1109/sbac-pad.2012.15.

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Costabello, Luca, Serena Villata, Nicolas Delaforge, and Fabien Gandon. "Ubiquitous access control for SPARQL endpoints." In the 21st international conference companion. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2187980.2188090.

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Mehdi, Muntazir, Aftab Iqbal, Aidan Hogan, Ali Hasnain, Yasar Khan, Stefan Decker, and Ratnesh Sahay. "Discovering domain-specific public SPARQL endpoints." In the 18th International Database Engineering & Applications Symposium. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2628194.2628220.

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Arkin, Esther M., Dan Halperin, Klara Kedem, Joseph S. B. Mitchell, and Nir Naor. "Arrangements of segments that share endpoints." In the seventh annual symposium. New York, New York, USA: ACM Press, 1991. http://dx.doi.org/10.1145/109648.109684.

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Li, Nanjun, and Werner Zorn. "Suggested Improvements for Wireless TCP Endpoints." In Future Generation Communication and Networking (FGCN 2007). IEEE, 2007. http://dx.doi.org/10.1109/fgcn.2007.206.

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Kienzle, Darrell, Nathan Evans, and Matthew Elder. "NICE: Network Introspection by Collaborating Endpoints." In 2013 IEEE Conference on Communications and Network Security (CNS). IEEE, 2013. http://dx.doi.org/10.1109/cns.2013.6682753.

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Reports on the topic "Endpoints"

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Efroymson, R. A., and G. W. II Suter. Preliminary remediation goals for ecological endpoints. Office of Scientific and Technical Information (OSTI), September 1995. http://dx.doi.org/10.2172/204209.

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Efroymson, R. A., G. W. II Suter, B. E. Sample, and D. S. Jones. Preliminary remediation goals for ecological endpoints. Office of Scientific and Technical Information (OSTI), July 1996. http://dx.doi.org/10.2172/266880.

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Hinton, Thimas G., and Joel Bedford. Determining Significant Endpoints for Ecological risk Analyses. Office of Scientific and Technical Information (OSTI), June 1999. http://dx.doi.org/10.2172/828354.

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Previdi, S., W. Henderickx, and D. Cooper. Interconnecting Millions of Endpoints with Segment Routing. Edited by C. Filsfils and G. Dawra. RFC Editor, June 2019. http://dx.doi.org/10.17487/rfc8604.

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Hinton, Thomas G. DETERMINING SIGNIFICANT ENDPOINTS FOR ECOLOGICAL RISK ANALYS ES. Office of Scientific and Technical Information (OSTI), December 2000. http://dx.doi.org/10.2172/828357.

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Johnston, A., E. Shim, and K. Singh. Simple SIP Usage Scenario for Applications in the Endpoints. Edited by H. Sinnreich. RFC Editor, September 2009. http://dx.doi.org/10.17487/rfc5638.

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Deeb, Rula, Elisabeth Hawley, Lauren Kell, and Robert O'Laskey. Assessing Alternative Endpoints for Groundwater Remediation at Contaminated Sites. Fort Belvoir, VA: Defense Technical Information Center, May 2011. http://dx.doi.org/10.21236/ada544571.

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Hinton, T. G., J. Congdon, C. Rowe, D. Scott, J. Bedford, and F. W. Whicker. Determining significant endpoints for ecological risk analyses. 1997 annual progress report. Office of Scientific and Technical Information (OSTI), November 1997. http://dx.doi.org/10.2172/13597.

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Hinton, T. G., J. Congdon, D. Scott, C. Rowe, J. Bedford, and W. Whicker. Determining significant endpoints for ecological risk analyses. 1998 annual progress report. Office of Scientific and Technical Information (OSTI), June 1998. http://dx.doi.org/10.2172/13598.

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Clemmons, M. A., M. J. Jusko, and R. G. Whitfield. Ozone risk assessment utilities (ORAMUS) user's manual and tutorial : Volume 1, Acute health endpoints. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/12029.

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You might also be interested in the extended bibliographies on the topic 'Endpoints' for particular source types:
Journal articles Dissertations / Theses Books
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