Relevant bibliographies by topics / Endosomolytic peptide

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  2. Dissertations / Theses

Academic literature on the topic 'Endosomolytic peptide'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Endosomolytic peptide"

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Abes, S., H. Moulton, J. Turner, P. Clair, J. P. Richard, P. Iversen, M. J. Gait, and B. Lebleu. "Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides." Biochemical Society Transactions 35, no. 1 (January 22, 2007): 53–55. http://dx.doi.org/10.1042/bst0350053.

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CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins or ONs (oligonucleotides). CPPs and their conjugates were initially thought to translocate through the cell membrane by a non-endocytotic mechanism which has recently been re-evaluated. Basic-amino-acid-rich CPPs first interact with cell-surface proteoglycans before being internalized by endocytosis. Sequestration and degradation in endocytotic vesicles severely limits the cytoplasmic and nuclear delivery of the conjugated biomolecules. Accordingly, splicing correction by CPP-conjugated steric-block ON analogues is inefficient in the absence of endosomolytic agents. New arginine-rich CPPs allowing efficient splicing correction by conjugated PNAs (peptide nucleic acids) or PMO (phosphorodiamidate morpholino oligomer) steric blockers in the absence of endosomolytic agents have recently been defined in our group and are currently being characterized. They offer promising leads for the development of efficient cellular delivery vectors for therapeutic steric-block ON analogues.
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Algayer, Bethany, Ann O’Brien, Aaron Momose, Dennis J. Murphy, William Procopio, David M. Tellers, and Thomas J. Tucker. "Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif." Molecules 24, no. 11 (May 31, 2019): 2079. http://dx.doi.org/10.3390/molecules24112079.

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Delivery of macromolecular cargos such as siRNA to the cytosol after endocytosis remains a critical challenge. Numerous approaches including viruses, lipid nanoparticles, polymeric constructs, and various peptide-based approaches have yet to yield a general solution to this delivery issue. In this manuscript, we describe our efforts to design novel endosomolytic peptides that could be used to facilitate the release of cargos from a late endosomal compartment. These amphiphilic peptides, based on a chimeric influenza hemagglutinin peptide/cell-penetrating peptide (CPP) template, utilize a pH-triggering mechanism in which the peptides are protonated after acidification of the endosome, and thereby adopt an alpha-helical conformation. The helical forms of the peptides are lytically active, while the non-protonated forms are much less or non-lytically active at physiological pH. Starting from an initial lead peptide (INF7-Tat), we systematically modified the sequence of the chimeric peptides to obtain peptides with greatly enhanced lytic activity that maintain good pH selectivity in a red blood cell hemolysis assay.
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Akishiba, Misao, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nakase, Tomoka Takatani-Nakase, Fatemeh Madani, Astrid Gräslund, and Shiroh Futaki. "Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide." Nature Chemistry 9, no. 8 (May 22, 2017): 751–61. http://dx.doi.org/10.1038/nchem.2779.

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Abes, R., A. A. Arzumanov, H. M. Moulton, S. Abes, G. D. Ivanova, P. L. Iversen, M. J. Gait, and B. Lebleu. "Cell-penetrating-peptide-based delivery of oligonucleotides: an overview." Biochemical Society Transactions 35, no. 4 (July 20, 2007): 775–79. http://dx.doi.org/10.1042/bst0350775.

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Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using steric-block ON (oligonucleotide) analogues, such as PNAs (peptide nucleic acids) or PMOs (phosphorodiamidate morpholino oligomers), has consequently been inefficient when ONs are conjugated with standard CPPs such as Tat (transactivator of transcription), R9 (nona-arginine), K8 (octalysine) or penetratin in the absence of endosomolytic agents. New arginine-rich CPPs such as (R-Ahx-R)4 (6-aminohexanoic acid-spaced oligo-arginine) or R6 (hexa-arginine)–penetratin conjugated to PMO or PNA resulted in efficient splicing correction at non-cytotoxic doses in the absence of chloroquine. SAR (structure–activity relationship) analyses are underway to optimize these peptide delivery vectors and to understand their mechanisms of cellular internalization.
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Ahmad, Aqeel, Kirsi Rilla, Jing Zou, Weikai Zhang, Ilmari Pyykkö, Paavo Kinnunen, and Sanjeev Ranjan. "Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide." International Journal of Pharmaceutics 601 (May 2021): 120556. http://dx.doi.org/10.1016/j.ijpharm.2021.120556.

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Ding, Hui, Jose Portilla-Arias, Rameshwar Patil, Keith L. Black, Julia Y. Ljubimova, and Eggehard Holler. "The optimization of polymalic acid peptide copolymers for endosomolytic drug delivery." Biomaterials 32, no. 22 (August 2011): 5269–78. http://dx.doi.org/10.1016/j.biomaterials.2011.03.073.

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7

Han, Muri, Valerie A. Kickhoefer, Glen R. Nemerow, and Leonard H. Rome. "Targeted Vault Nanoparticles Engineered with an Endosomolytic Peptide Deliver Biomolecules to the Cytoplasm." ACS Nano 5, no. 8 (July 26, 2011): 6128–37. http://dx.doi.org/10.1021/nn2014613.

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8

Evans, Brian C., Kyle M. Hocking, Kameron V. Kilchrist, Eric S. Wise, Colleen M. Brophy, and Craig L. Duvall. "Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction." ACS Nano 9, no. 6 (June 2, 2015): 5893–907. http://dx.doi.org/10.1021/acsnano.5b00491.

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Lindberg, Staffan, Andrés Muñoz-Alarcón, Henrik Helmfors, Diogo Mosqueira, Daniel Gyllborg, Oana Tudoran, and Ülo Langel. "PepFect15, a novel endosomolytic cell-penetrating peptide for oligonucleotide delivery via scavenger receptors." International Journal of Pharmaceutics 441, no. 1-2 (January 2013): 242–47. http://dx.doi.org/10.1016/j.ijpharm.2012.11.037.

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Duvall, Craig L., Anthony J. Convertine, Danielle S. W. Benoit, Allan S. Hoffman, and Patrick S. Stayton. "Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer." Molecular Pharmaceutics 7, no. 2 (February 2010): 468–76. http://dx.doi.org/10.1021/mp9002267.

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Dissertations / Theses on the topic "Endosomolytic peptide"

1

Liu, Xiaowen [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Intracellular Protein delivery by defined polycations or combining a targeting ligand with an endosomolytic peptide / Xiaowen Liu ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1120302498/34.

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