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Dissertations / Theses on the topic 'Endonucleasi'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

FIRRITO, CLAUDIA. "Targeted Gene Correction and Reprogramming of SCID-X1 Fibroblasts to Rescue IL2RG Expression in iPSC-derived Hematopoietic Cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94656.

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La terapia genica basata sull’utilizzo di vettori integranti è stata già applicata con successo per la cura di varie malattie genetiche come le malattie da accumulo lisosomiale (LSD), la beta-talassemia (β-Thal) e le immunodeficienze primarie (PID). L’immunodeficienza combinata grave legata al cromosoma X (SCID-X1) è una malattia monogenica letale causata da mutazioni del gene codificante la catena comune gamma del recettore per l’interleuchina 2 (IL2RG). I primi studi clinici per la SCID-X1 hanno mostrato il potenziale terapeutico della terapia genica basata su vettori integranti, risultando

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2

Daniels, Lucy Elizabeth. "The SgrAI restriction endonuclease." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393877.

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3

Chevalier, Brett S. "Homing endonuclease mechanism, structure and design /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/4984.

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4

AlMalki, Faizah. "Structural studies on flap endonuclease complexes." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7293/.

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Flap endonucleases (FENs) are structure-specific enzymes that play critical roles in DNA replication and repair. Three members of the FEN family have been investigated during this project in complexes with DNA substrates and metal ions: bacteriophage T5FEN, hFEN and Trypanosoma brucei FEN. T5FEN wild type and two catalytically inactive versions, D153K and D155K were successfully crystallized in complexes with DNA substrates containing 5' or 3' overhangs. The crystal structure for T5FEN-D153K in complex with a duplex containing 5' overhangs at each end and two Mg2+ ions was solved. The structur

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5

Barzilay, Gil. "Characterisation of human AP endonuclease I (HAP1)." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318791.

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6

Pernstich, Christian. "Protein dynamics of the restriction endonuclease Fokl." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526007.

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7

Stanford, Neil Philip. "DNA cleavage by the EcoRV restriction endonuclease." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299311.

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8

Wentzell, Lois Marie. "DNA communications by the SfiI restriction endonuclease." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388002.

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9

Hanson, Mark Nils. "Biochemical characterization of the endonuclease PMR-1 /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488204276532461.

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10

Zhao, Lei. "Characterization of bacterial homing endonuclease I-Ssp6803I /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/9214.

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11

Reuter, Monika. "Die Restriktionsendonuklease EcoRII: Primitives antivirales Abwehrsystem der Bakterien oder mehr?" Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13829.

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Bakterielle Restriktions- und Modifikationssysteme (R/M-Systeme) greifen DNA endonukleolytisch an, die nicht die spezifische Markierung der eigenen Wirtszelle trägt. Zu einem R/M-System gehören eine Restriktionsendonuklease und eine DNA- Methyltransferase gleicher DNA-Spezifität. Die biologische Funktion der Restriktionsendonuklease besteht in der Abwehr von fremder, in die Zelle eindringender DNA, z. B? von Virus-Infektionen. Die korrespondierende DNA-Methyltransferase schützt die zelluläre DNA durch sequenz-spezifische DNA-Methylierung vor der endonukleolytischen Wirkung der Restriktionsendo

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12

Wood, Katie Maria. "Interactions of the SgrAl restriction endonuclease with oligoduplexes." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407034.

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13

Oates, S. L. "Molecular characterisation of the Trypanosoma brucei flap endonuclease." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/14274/.

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14

Algasaier, Sana. "Mechanistic studies of flap endonuclease-1 (FEN-1)." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19940/.

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15

Luke, P. A. "The EcoRI and EcoRV restriction endonucleases." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372027.

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16

Goddard, Matthew. "The ecology and evolution of selfish genes." Thesis, Imperial College London, 2000. http://hdl.handle.net/10044/1/11419.

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17

Jacobs, D. "Type II restriction-modified systems in Enterobacter aerogenes and Herpetosiphon giganteus." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379680.

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18

Lagerbäck, Pernilla. "Endonuclease II - a GIY-YIG enzyme of bacteriophage T4." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9410.

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Endonuclease II (EndoII) of bacteriophage T4 is a GIY-YIG enzyme involved in host DNA breakdown during phage infection of E. coli. EndoII combines features of restriction endonucleases with those of homing endonucleases in that it breaks down DNA foreign to itself but recognizes a 16 bp long asymmetric and ambiguous sequence. This investigation addresses the biological function of EndoII, its mode of interaction with its substrate and roles of individual residues in catalysis, sequence recognition and binding. It is shown here that EndoII increases the frequency of non-homologous recombination

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19

Sukackaitė, Rasa. "Structural and functional studies of the restriction endonuclease BpuJI." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091215_091842-18511.

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Type II restriction endonucleases recognize specific DNA sequences and cleave DNA at fixed positions within or close to this sequence. BpuJI recognizes the 5’-CCCGT sequence, but in contrast to other enzymes its cleavage site is very variable. This study shows that BpuJI is a dimer in solution and consists of two separate domains. The N-domain binds to the target sequence as a monomer, while the C-domain is responsible for nuclease activity and dimerization. The nuclease activity is repressed in the apo-enzyme and becomes activated upon specific DNA binding by the N-domains. The activated C-do

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20

Walker, David Colin. "Translocation and cytotoxicity of the HNH endonuclease colicin E9." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368143.

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21

Williams, Shelley Ann. "Reactions of the SfiI restriction endonuclease with DNA duplexes." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326390.

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22

Nichols, Claire. "Structure-Function Studies of SgrAI: An Allosteric Restriction Endonuclease." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/144913.

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23

Walker, Jeremy N. B. "Identification and characterisation of novel restriction endonucleases." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277215.

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24

Marshall, Jacqueline Johanna Tabitha. "BcgI and other type IIB restriction endonucleases." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435433.

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25

Guha, Tuhin. "Biochemical characterization of homing endonucleases encoded by fungal mitochondrial genomes." PLoS ONE, 2014. http://hdl.handle.net/1993/31680.

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The small ribosomal subunit gene of the Chaetomium thermophilum DSM 1495 is invaded by a nested intron at position mS1247, which is composed of a group I intron encoding a LAGLIDADG open reading frame interrupted by an internal group II intron. The first objective was to examine if splicing of the internal intron could reconstitute the coding regions and facilitate the expression of an active homing endonuclease. Using in vitro transcription assays, the group II intron was shown to self-splice only under high salt concentration. Both in vitro endonuclease and cleavage mapping assays suggested

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26

Russell, Anthony George. "Characterization of a novel archaeal RNA endonuclease from Sulfolobus acidocaldarius." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ56609.pdf.

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27

Lu, Jian. "The Kluyveromyces lactis killer toxin is a transfer RNA endonuclease." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1092.

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28

Repanas, Konstantinos. "Structural and functional studies on the LINE-1 retrotransposon endonuclease." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10512.

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29

Šilanskas, Arūnas. "Restriction endonuclease-triplex forming oligonucleotide conjugates with controllable catalytic activity." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120702_082537-22107.

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Simple mutations within the coding region of critical human genes can lead to the formation of abnormal proteins, resulting in various diseases (e.g. cancer), in failure of an embryo to develop, or premature death. Genetic diseases can only be truly cured via restoration of defective gene function and one of the most promising strategies is based on homologous recombination. Naturally homologous recombination occurs with a low frequency (1 in 106 transfected cells), however it is known that DNA double-strand breaks enhance the efficiency of homologous recombination by several orders of magnitu

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30

Preece, Fiona Louise. "Reactions at two DNA sites by the BSPMI restriction endonuclease." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495821.

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31

Keeble, Anthony Howard. "Biophysical analysis of ligand binding to the colicin E9 endonuclease." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251393.

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32

Elliott, Sarah Louise. "E. coli Vsr endonuclease : mechanism and role in mismatch repair." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417442.

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33

Mosbahi, KheÌdidja. "Interaction of the endonuclease domain of colicin E9 with membranes." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399260.

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34

Erskine, Symon George. "The kinetics of DNA cleavage by the EcoRV restriction endonuclease." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388107.

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35

Lau, Roxanne. "Characterisation of the streptococcal DNA polymerase I flap endonuclease domain." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19951/.

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36

Meisenberg, Cornelia. "The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:9a6582d4-6fc0-48c9-9c13-6c99e23e66e9.

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Apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair factor involved in the DNA base excision repair (BER) pathway that is required for the maintenance of genome stability. In this pathway, APE1 cleaves DNA at an abasic site to generate a DNA single strand break, allowing for repair completion by a DNA polymerase and a DNA ligase. High levels of APE1 have been observed in multiple cancer types however it is not understood if this contributes to cancer onset and development. What is known is that these cancers tend to display increased resistance to DNA damaging treatments and APE1 i

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37

Delgadillo, Liberona José Sebastián. "Clonamiento, expresión y purificación de las endonucleasas apurínicas/apirimidínicas TcAP1 y TcAP2 de Trypanosoma cruzi en condiciones nativas." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/131433.

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Memoria para optar al Título Profesional de Médico Veterinario<br>El agente causal de la enfermedad de Chagas o tripanosomiasis americana, es el parásito hemoflagelado Trypanosoma cruzi. Esta enfermedad es de carácter endémico en América Latina; se estima un promedio de 10-15 millones de personas infectadas y 75-90 millones en riesgo de contraer la enfermedad. T. cruzi posee un ciclo de vida indirecto y se presenta en cuatro formas celulares; epimastigote, forma extracelular replicativa y no infectiva, tripomastigote metacíclico y tripomastigote sanguíneo, formas no replicativas e infectivas y

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38

Dance, Geoffrey Stephen Charles. "Endonucleases involved in mRNA decay in E. coli." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260160.

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39

Bolton, Bryan John. "Class II restriction endonucleases : screening, purification and characterization." Thesis, University of Salford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240035.

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40

Bilcock, Denzil Trevor. "DNA communications by SfiI and other restriction endonucleases." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299592.

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41

Jakimo, Noah Michael. "Genomic nucleic acid memory storage with directed endonucleases." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98625.

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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 40-41).<br>Technologies for long-term recording of cellular pathway activation are constrained by the difficultly to constantly monitor transient signaling events and expression of target genes. To overcome these limitations we designed a recording tool that uses the transcriptional output of a signaling pathway as the input for an engineered genome encoded memory. The mechanism

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42

Gao, Honghai. "Biochemical study of endonuclease V and its application in mutation scanning." Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1181252071/.

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43

Mitchell, Belinda Michon Hall. "Restriction endonuclease analysis of chromosomal DNA from campylobacter and helicobacter organisms." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/25220.

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44

Gorman, Michael Anthony. "Crystal structure of the human DNA repair enzyme AP endonuclease 1." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242493.

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45

Makovets, Svetlana. "Regulation of the endonuclease activity of type 1 restriction-modification systems." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/11090.

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Efficient acquisition of the genes (<I>hsdR, M</I> and <I>S</I>) that specify <I>Eco</I>KI and <I>Eco</I>AI, representatives of two families of type I restriction and modification (R-M) systems, was shown to require a product of an unknown gene <I>hsd</I>C. The <I>hsd</I>C mutant is shown to have a mutation in <I>clp</I>X. ClpP, the components of ClpXP protease, are necessary for the efficient transmission of the <I>hsd</I> genes by conjugation, transformation and P1 transduction. Inactivation of <I>clp</I>X leads to a bigger barrier than a similar mutation in <I>clpP</I> consistent with a cha

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46

Techner, José-Marc. "Sequence Affinity Studies of E301W, A Mutant of Restriction Endonuclease SgrAI." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144972.

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47

Patel, Nikesh. "Mechanistic and structural studies of the helical arch of flap endonuclease." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3135/.

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Fluorescence anisotropy measurements were also carried out in order to determine the dissociation constant of the synthesised oligos bound to FEN enzymes and validate conditions used in the aforementioned competition experiments. These experiments revealed a small dependence on substrate flap length to binding, and showed stimulation of KD on the addition of divalent metal ions. This was likely due to shielding of 7/8 conserved carboxylates that ligand divalent metal ions within the active site of the enzyme. Measurements with hFEN1 mutants, also highlighted the fact that initial binding of su

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48

Silva, Rita de C?ssia Barreto da. "Caracteriza??o de uma nova exonuclease identificada em uma biblioteca metagen?mica." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br/handle/123456789/19374.

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49

Sandegren, Linus. "Group I Introns and Homing Endonucleases in T-even-like Bacteriophages." Doctoral thesis, Stockholm : Institutionen för molekylärbiologi och funktionsgenomik, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-211.

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50

Kim, Hyong-ha. "A novel intron-encoded endonuclease derived from the fourth intron of the Chlamydomonas reinhardtii psbA gene /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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