Relevant bibliographies by topics / Endometriosis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Endometriosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Endometriosis"

1

Borisova, E. A., M. N. Bulanov, and T. A. Makarenko. "Ultrasound image of ovarian endometrioma as an indicator of external genital endometriosis." Ultrasound & Functional Diagnostics, no. 3 (February 13, 2024): 37–49. http://dx.doi.org/10.24835/1607-0771-2023-3-37-49.

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Timely preoperative diagnosis of endometrioic cyst (endometrioma), as well as deep endometriosis remains relevant. The aim of the study was to assess the diagnostic value of ultrasound in patients with endometriomas and assess the combination of them with other foci of external genital endometriosis. The study based on retrospective analysis of a date of 95 patients with ultrasound signs of ovarian endometriomas, who underwent examination in MedicoProfi LLC – Borisov Medical and Diagnostic Clinic (Krasnoyarsk) during the period from January 2019 to October 2023. All of patients underwent surgery , followed by morphological evaluation. In the vast majority of cases, it was possible to detect a combination of endometriomas with one or more foci of deep endometriosis. Superficial peritoneal endometriosis and adhesions were found on surgery in all cases when endometriomas appeared isolated on ultrasound. The results of the study showed: endometriomas combined with deep endometriosis in 96.8% of cases. Thus, ultrasound detection of endometrioma is a very reliable sign of deep endometriosis presence. The “kissing ovaries” symptom in bilateral endometriomas can be considered as an absolutely reliable sign of the uterosacral ligaments endometriosis with specificity of 100% and positive predictive value of 100%. The presence of the “kissing ovaries” sign should be depicted in the conclusion of the ultrasound protocol, since it highly suggestive to obliteration of the pouch of Douglas and involvement of adjacent organs (fallopian tubes, intestines, ureters, etc.) in the endometrioid infiltrates, which is extremely important for the surgery planning, as well as in patients with infertility. There is an obvious need to introduce the extended pelvic ultrasound protocol to the diagnostic algorithm for patients with suspected endometriosis, which will more accurately describe the disease extension.
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Davydov, A. I., L. M. Mikhaleva, M. B. Khabarova, R. A. Chilova, and V. A. Lebedev. "Endometrioid cystadenoma – deep ovarian endometriosis." Voprosy ginekologii, akušerstva i perinatologii 21, no. 3 (2022): 130–37. http://dx.doi.org/10.20953/1726-1678-2022-3-130-137.

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Among all endometriosis lesions of female reproductive organs, ovarian endometrioma is the most discussed nosology. Since 2014, ovarian endometrioid cysts have been classified as benign tumors (WHO Classification of Tumours of Female Reproductive Organs, 4th edition). In 2021, the 11th revision of the International Classification of Diseases (ICD-11) was amended, according to which the term “endometrioid ovarian cyst” (from 2018 to 2021 – heading GA18.3 Ovarian endometriotic cyst, section GA18 Acquired abnormalities of ovary) is no longer used, and the clinical and morphological signs of these cysts are presented in the heading GA10.B5 Deep ovarian endometriosis. In 2020, WHO updated the histological classification of female genital tumors (Female Genital Tumours WHO Classification of Tumours, 5th Edition), in which the section “endometrioid tumors” is presented only with endometrioid cystadenoma and endometrioid adenofibroma without mentioning the endometrioid cyst, but in accordance with the ICD-11, endometrioid cystadenoma is coded as “GA10.B5 Deep ovarian endometriosis”. Thus, on the one hand, ovarian endometrioma is a neoplastic process and requires appropriate approaches when choosing treatment tactics, on the other hand, cystectomy for endometrioma is accompanied by a pronounced loss of ovarian reserve. A possible consensus in this problem seems to be a minimally invasive method in the treatment of patients with ovarian endometriomas – ethanol sclerotherapy with cytological examination of the aspirate obtained from the neoplasm. The effectiveness of sclerotherapy largely depends on the choice of postoperative hormonal therapy. Today, dienogest is considered to be the most effective “anti-endometrioid” progestogen. However, there is an erroneous opinion that ethinylestradiol neutralizes the antiproliferative effect of dienogest and stimulates the growth of endometriosis. On the contrary, ethinylestradiol enhances the inhibitory effect of progestogen on the growth of ovarian endometrioma cells. Key words: endometrioid cystadenoma, ovarian endometrioma, deep ovarian endometriosis, sclerotherapy, dienogest
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3

Korchynska, O. O., I. I. Khashcha, and D. Stryzhak. "Oncological aspects of ovarian endometriosis." Reproductive health of woman, no. 1 (March 1, 2024): 10–14. http://dx.doi.org/10.30841/2708-8731.1.2024.301575.

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Ovarian cancer is the second most common cause of death from gynaecological malignancies in the world, and in Ukraine it is the most serious type of gynecological cancer. Ovarian endometriomas significantly increase the risk of ovarian cancer, but their malignant transformation occurs in approximately 1% of cases.The article presents a literature review based on the scientific databases PubMed and Scopus for 2013–2023 on the incidence and frequency of ovarian malignant tumors on the background of ovarian endometriosis, carcinogenic mutations, immunological and hormonal disorders in ovarian endometriosis, which can cause its progression to ovarian cancer.Based on the analyzed scientific data, the connection between ovarian endometriosis and ovarian cancer is presented and all possible pathogenetic pathways through which ovarian endometriosis can lead to the formation of ovarian cancer are determined.According to the scientific literature, ovarian endometriosis can indeed lead to the formation of endometrioid and clear cell carcinomas, as well as other subtypes of malignant ovarian tumors. The risk of malignant changes in patients with ovarian endometriomas increases with age, the highest risk is observed in patients over 50 years of age. Despite this, some researchers believe that there are no time limits in the occurrence of malignant transformation of endometrioid ovarian cysts.Today, it is believed that atypical ovarian endometriosis, which is characterized by cytological atypia and architectural proliferation, is a precursor to ovarian cancer, and this condition that has the greatest risk for malignant process development is observed. Ovarian endometriomas contain a huge amount of heme and free iron, which leads to the appearance of an excess of free iron, and as a result, redox disorders occur, which cause carcinogenic mutations and destruction of cellular structures.Mutations in such genes as ARID1A, PIK3CA, AKT1, ERBB2 and PIK3R1, CTNNB1, KRAS, BRAF, PPP2R1A and occasionally in TP53 gene are involved in the occurrence of malignant changes in ovarian endometriomas. The same mutations are found in endometrioid foci of the ovaries and in endometrioid and clear cell carcinomas, which confirms the cancer development due to endometriosis. Disorders in the immune system in endometrioid lesions of the ovaries play a significant role in possible malignant transformation. The production of tumor necrosis factor, interleukin-1β, interleukin-6 increases, the function of natural killers decreases, and immunosuppression increases.Ovarian endometrioid cysts overexpress estradiol because they have increased amounts of the enzyme aromatase and lack the enzyme 17β-hydroxysteroid dehydrogenase type II, which is required to convert estradiol to estrone. Such changes lead to increased proliferative processes, which can also lead to the activation of oncogenic mutations.Thus, ovarian endometriosis significantly increases the risk of developing ovarian cancer, especially endometrioid and clear cell carcinomas. The mechanism of malignant transformation occurs precisely with the appearance of atypical endometriosis of the ovaries. The main pathogenetic pathways through which a malignant process can develop in ovarian endometriomas include: redox imbalance, which triggers a whole spectrum of oncogenic mutations, as well as immune disorders and exposure to high levels of estrogens. However, if patients with ovarian endometriomas are properly managed, the likelihood of ovarian cancer development is low.
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4

Wendel, Jillian, Xiyin Wang, and Shannon Hawkins. "The Endometriotic Tumor Microenvironment in Ovarian Cancer." Cancers 10, no. 8 (August 7, 2018): 261. http://dx.doi.org/10.3390/cancers10080261.

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Women with endometriosis are at increased risk of developing ovarian cancer, specifically ovarian endometrioid, low-grade serous, and clear-cell adenocarcinoma. An important clinical caveat to the association of endometriosis with ovarian cancer is the improved prognosis for women with endometriosis at time of ovarian cancer staging. Whether endometriosis-associated ovarian cancers develop from the molecular transformation of endometriosis or develop because of the endometriotic tumor microenvironment remain unknown. Additionally, how the presence of endometriosis improves prognosis is also undefined, but likely relies on the endometriotic microenvironment. The unique tumor microenvironment of endometriosis is composed of epithelial, stromal, and immune cells, which adapt to survive in hypoxic conditions with high levels of iron, estrogen, and inflammatory cytokines and chemokines. Understanding the unique molecular features of the endometriotic tumor microenvironment may lead to impactful precision therapies and/or modalities for prevention. A challenge to this important study is the rarity of well-characterized clinical samples and the limited model systems. In this review, we will describe the unique molecular features of endometriosis-associated ovarian cancers, the endometriotic tumor microenvironment, and available model systems for endometriosis-associated ovarian cancers. Continued research on these unique ovarian cancers may lead to improved prevention and treatment options.
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Manu, Andrei, Ciprian Andrei Coroleucă, Cătălin Bogdan Coroleucă, Diana-Elena Comandașu, Diana-Elena Soare, Alexandra Bauşic, Cristina-Maria Iacob, Mihaela-Arina Banu, Anca Hashemi, and Elvira Brătilă. "Endometriomul ovarian – vârful aisbergului?" Obstetrica şi Ginecologia 2, no. 1 (June 30, 2023): 73–76. http://dx.doi.org/10.26416/obsgin.71.2.2023.8874.

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Endometriosis is a chronic disease that affects around 10% of women who are of reproductive age. It may lead to significant morbidity, and it is a serious public health concern. Ovarian lesions, such as endometriomas or traditional ovarian cysts, are the most common localizations of endometriosis. Transvaginal ultrasonography is the first-line imaging modality for predicting deeply infiltrating endometriosis and is a straightforward diagnostic technique with a good diagnostic accuracy for endometriomas. A total of 437 patients who underwent preoperative ultrasonography examination and underwent surgery for deeply infiltrating endometriosis were included in our retrospective observational study. Of these, 45.2% (152 patients) had an endometriosis cyst diagnosis alone, with no further deep endometriosis lesions detected by ultrasonography; nevertheless, a number of patients had numerous deeply infiltrating lesions diagnosed intraoperatively. The objective of the present research was to evaluate the correlation between the sonographic identification of ovarian endometriomas and the detection of particular extraovarian endometriotic lesions, such as parametrial, rectovaginal and intestinal lesions, using transvaginal ultrasound.
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Blontzos, Nikolaos, Despoina Mavrogianni, Konstantinos Ntzeros, Nikolaos Kathopoulis, Athanasios Moustogiannis, Anastassios Philippou, Michael Koutsilieris, and Athanasios Protopapas. "Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study." Biomolecules 14, no. 1 (December 20, 2023): 7. http://dx.doi.org/10.3390/biom14010007.

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Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls. We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes. We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules. In conclusion, differential expression of IGF-1 isoforms may indicate that DIE with its associated ovarian lesions and simple ovarian endometriosis should be considered as two forms of the disease developing under different molecular pathways.
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Ilgen, Orkun, Sefa Kurt, Deniz Gokcay, and Emine Cagnur Ulukus. "Malignant transformation of endometriosis on vaginal cuff after hysterectomy: a case report." Journal of Clinical and Investigative Surgery 6, no. 2 (November 15, 2021): 161–65. http://dx.doi.org/10.25083/2559.5555/6.2.13.

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Objective. Endometriotic tissue implants rarely transform to malignant tissue, especially in a patient with a hysterectomy and bilaterally salpingo-oophorectomy. However, several cases with cancer arising from endometriosis after hysterectomy were reported in the literature. Hormone replacement therapy only with estrogen is a crucial risk factor for malignant transformation of persistent endometriotic tissue. Case Report. The present case demonstrates an endometrioid adenocarcinoma arising from persistent endometriosis tissue in a patient who was performed hysterectomy with bilateral salpingectomy 3 years ago. The histopathologic specimens of the previous surgery did not include any malignant tissue. After 3 years, she applied to the hospital with abnormal vaginal bleeding, and her histopathologic examination result found an ulcerated mass at the upper one-third of the vagina that is compatible with endometrioid adenocarcinoma. Conclusion. It is crucial to keep in mind the endometriosis history of the patient, to be able to diagnose cancer arising from endometriosis while evaluating the patient with a hysterectomy.
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Okulova, E. O., O. A. Melkozerova, A. A. Mikhelson, G. B. Malgina, T. B. Tretyakova, and T. A. Putilova. "Activating mutations of genes in the PI3K/AKT/mTOR signaling pathway and ovarian reserve status in patients of reproductive age with deep infiltrating endometriosis." Voprosy ginekologii, akušerstva i perinatologii 20, no. 6 (2021): 92–100. http://dx.doi.org/10.20953/1726-1678-2021-6-92-100.

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Objective. To study the effect of deep infiltrating endometriosis on the status of ovarian reserve in patients of reproductive age and to assess the spectrum of PIK3CA gene mutations among patients with infiltrating form of external genital endometriosis. Patients and methods. The study group included 50 patients of reproductive age with deep infiltrating endometriosis, of whom 18 had deep infiltrating endometriosis combined with ovarian endometriomas. The comparison group included 25 patients of reproductive age who underwent laparoscopic metroplasty of post-cesarean section uterine scar. In all patients, serum levels of anti-mullerian hormone (AMH), follicle-stimulating hormone, and estradiol were determined by enzyme immunoassay, and an antral follicle count in the ovaries was done via transvaginal ultrasound. The search for activating mutations in the PIK3CA gene was performed by next-generation DNA sequencing in the samples of ovarian endometriomas from patients with a combination of infiltrating endometriosis and endometrioid cysts (n = 18) and in biopsy samples of healthy ovarian tissue from all patients in the study (n = 50) and comparison groups (n = 25). Results. Evaluation of the ovarian reserve status in patients from two groups showed that levels of AMH were lower in patients with infiltrating form of external genital endometriosis than in the comparison group by 1.0 ng/mL on average (2.6 ± 2.2 ng/mL in the study group, 3.6 ± 3.5 ng/mL in the comparison group), but the difference was not statistically significant, p > 0.05. The number of antral follicles according to transvaginal ultrasound was significantly lower in the study group (8.5 ± 4.5) than in the comparison group (12.2 ± 4.1), p = 0.001. This difference was statistically significant both for patients with ovarian endometriomas (6.0 ± 4.2, p < 0.001) and for patients without ovarian endometrioid tumors (9.8 ± 4.2, p = 0.04). Our study did not detect PIK3CA gene mutations in any of the ovarian endometrioma tissue samples from patients with a combination of infiltrating endometriosis and endometrioid cysts, and in none of the healthy ovarian tissue biopsy samples from patients in the study and comparison groups. Conclusion. Thus, the presence of deep infiltrating endometriosis is associated with diminished ovarian reserve in patients of reproductive age, regardless of the presence of ovarian endometrioid tumors. Population studies are needed to detect PIK3CA gene mutations in endometriosis, as well as to investigate mutations in other genes encoding regulatory proteins of the PI3K/AKT/mTOR anti-apoptotic signaling pathway to reveal the mechanisms of ovarian reserve depletion in case of infiltrating forms of external genital endometriosis. Key words: infertility, deep infiltrating endometriosis, ovarian reserve, PI3K/AKT/mTOR signaling pathway, ovarian endometrioma
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Melkozerova, Oxana A., Ekaterina O. Okulova, Anna A. Mikhelson, and Tatyana B. Tretyakova. "The role of mutations in the PI3K/AKT/mTOR signal pathway in decreasing ovarian reserve in reproductive patients with deep infiltrative endometriosis." Gynecology 23, no. 6 (December 15, 2021): 548–53. http://dx.doi.org/10.26442/20795696.2021.6.201012.

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Aim. To study the effect of deep infiltrative endometriosis on the state of the ovarian reserve in patients of reproductive age, as well as to evaluate the spectrum of mutations in the PIK3CA gene among patients with infiltrative form of external genital endometriosis. Materials and methods. The main group of the study included 50 patients of reproductive age with deep infiltrative endometriosis, in 18 of whom deep infiltrative endometriosis was combined with ovarian endometriomas. The comparison group included 25 patients of reproductive age who underwent laparoscopic metroplasty of an inconsistent uterine scar from a cesarean section. All patients underwent determination of the level of anti-Mllerian hormone, follicle-stimulating hormone and estradiol in the blood by enzyme immunoassay, as well as counting the number of antral follicles in the ovaries during transvaginal ultrasound examination. The search for activating mutations of the PIK3CA gene was carried out by sequencing a new generation of DNA in tissue samples of ovarian endometriomas in patients with a combination of infiltrative endometriosis and endometrioid ovarian cysts (n=18), as well as in biopsies of healthy ovarian tissue in all patients of the main group (n=50) and comparison groups (n=25). Results. When assessing the state of the ovarian reserve in the patients of the two groups, it was found that the anti-Mllerian hormone level in the patient with the infiltration form of external genital endometriosis was 2.62.2 ng/ml, while in the comparison group it was 3.63.5 ng/ml, however, the difference did not reach statistical significance, p0.05. The number of antral follicles according to transvaginal ultrasound was significantly lower in the main group (8.54.5) than in the comparison group (12.24.1), p=0.001. This difference was statistically significant both for patients with ovarian endometriomas (6.04.2, p0.001) and for patients without ovarian endometriomas (9.84.2, p=0.04). Our study did not reveal PIK3CA gene mutations in any of the ovarian endometrioma tissue samples from patients with a combination of infiltrative endometriosis and endometrioid ovarian cysts, as well as in none of the healthy ovarian tissue biopsies from patients of the main group and the comparison group using the new generation DNA sequencing method. Conclusion. The presence of deep infiltrative endometriosis is associated with a decrease in ovarian reserve in patients of reproductive age, regardless of the presence of endometrioid ovarian lesions. Population studies are needed to identify mutations of this gene in endometriosis, as well as to study mutations of other genes encoding proteins regulating the antiapoptotic signaling pathway PI3K/AKT/mTOR, to identify the mechanism of ovarian reserve depletion in infiltrative form of external genital endometriosis.
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Andreeva, Nelly Yu, Maria I. Yarmolinskaya, Elena V. Misharina, Gulrukhsor Kh Tolibova, and Valeriia O. Semenova. "Evaluation of survivin expression in the endometrium and endometriotic lesions in patients with genital endometriosis, type 1 diabetes mellitus and their comorbidity." Journal of obstetrics and women's diseases 72, no. 3 (July 14, 2023): 5–13. http://dx.doi.org/10.17816/jowd345406.

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BACKGROUND: The prevalence of external genital endometriosis is high, yet there is insufficient understanding of its etiology and pathogenesis. This coupled with the challenges posed by its diagnosis and treatment, and its co-occurrence with type 1 diabetes mellitus, underscores the significance of this issue. AIM: The aim of this study was to evaluate the expression of survivin in the eutopic endometrium, endometriotic lesions, and their concomitant conditions in patients with external genital endometriosis and type 1 diabetes mellitus. MATERIALS AND METHODS: This study enrolled 43 female patients of reproductive age who were divided into four groups. The main group (n = 17) included women with surgically and histologically confirmed external genital endometriosis combined with type 1 diabetes mellitus. The external genital endometriosis group (n = 9) comprised women with isolated external genital endometriosis, while the type 1 diabetes mellitus group (n = 6) included patients with type 1 diabetes mellitus only. Finally, the control group (n = 6) consisted of women without any gynecological pathology. Biological specimens were collected during the follicular phase of the menstrual cycle, and morphological examination was carried out through histological and immunohistochemical evaluation of the endometrium and endometrioid heterotopias. Statistical analysis of the data was performed using the Jamovi software program, with statistical significance defined as p 0.05. RESULTS: Our findings indicate that patients with external genital endometriosis and comorbid type 1 diabetes mellitus exhibit a statistically significant increase in survivin expression in the endometrium compared to the control group or patients with type 1 diabetes mellitus only. However, no significant difference was observed in survivin expression in endometriotiс lesions between patients with external genital endometriosis and those with external genital endometriosis combined with type 1 diabetes mellitus. CONCLUSIONS: The data obtained suggest the role of survivin in the pathogenesis of external genital endometriosis, regardless of the presence of type 1 diabetes mellitus.
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Dissertations / Theses on the topic "Endometriosis"

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Ersoy, Burcu. "Development of peritoneal endometriosis: Characterisation of immune environment in peritoneal endometriotic lesions." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13848.

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Endometriosis is an inflammatory condition in which the immune system is thought to play a fundamental role in establishment and progression. Within peritoneal endometriotic lesions there is evidence of increased immune cell recruitment and activation. However, it is still unclear how the immune environment relates to peritoneal endometriotic lesion development. Therefore, the main aim of this project was to investigate peritoneal endometriotic lesion development by characterising the immune environment by macroscopic appearance (red, black and white scarred). Peritoneal endometriotic lesions were prospectively collected and immunohistochemically stained to identify T cells, B cells, macrophages and dendritic cells. Immune cells were present in both the endometriotic stroma and lesion-surrounding tissue. Additionally, there were some differences in immune cell population densities between stroma and surrounding tissue. Also a number of correlations were found between the densities of different immune cell populations in both tissue types, indicating relationships and interactions between cell types. The density of immune cells in and around peritoneal endometriotic lesions was not correlated with lesion appearance. The recruitment of immune cells to tissue within and around peritoneal endometriotic lesions is likely an attempt to attack the lesion. However, products released by these cells may in fact promote processes such as angiogenesis and fibrosis and thereby lesion growth and persistence. The findings from this thesis have implications for understanding of endometriosis pathogenesis, and also potentially for development of novel treatment approaches.
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TOZZI, ALESSANDRA. "The unfolded protein response: a link between endometrioid ovarian carcinoma and endometriosis." Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245358.

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Lo scopo del seguente lavoro è di analizzare il profilo di attivazione dei geni legati al pathway dell’Unfolded Protein Response (UPR) nel carcinoma endometrioide dell’ovaio e di valutare il suo possibile coinvolgimento nella trasformazione neoplastica dell’endometriosi. Lo studio è stato eseguito utilizzando diversi campioni istologici: carcinoma endometrioide dell’ovaio, tessuto ovarico sano, cisti endometriosica, endometrio eutopico provenienti da pazienti con endometriosi e da pazienti con endometrio sano. Da tutti i campioni è stato estratto l’RNA e sintetizzato il cDNA utilizzando la trascrizione inversa. Il cDNA è stato utilizzato per i saggi di espressione quantitativa dei geni, tramite Real Time PCR, con analisi dei geni appartenenti al pathway dell’UPR. I campioni sono stati divisi in tre gruppi: patienti con endometriosi (n=6), pazienti sane (n=6) e pazienti con carcinoma endometrioide dell’ovaio (n=6). L’analisi statistica effettuata è il t-test, con analisi delle differenze statistiche tra i dati provenienti da pazienti sane (CTRL) e pazienti affette da endometriosi (Ectopic e Eutopic) e pazienti affette da carcinoma endometrioide dell’ovaio (CA). Abbiamo in primo luogo analizzato la differente espressione del pathway dell’UPR nel carcinoma endometrioide dell’ovaio, comparandolo al tessuto ovarico sano e abbiamo dimostrato un’alterata espressione dei geni dell’UPR nelle pazienti tumorali. In secondo luogo, abbiamo analizzato l’espressione genica dell’UPR nel carcionma endometrioide ovarico, comparandola all’endometrio sano di pazienti sane e di pazienti affette da endometriosi. Il nostro studio mostra una graduale riduzione dell’espressione del gene XBP1 nell’endometriosi, caratterizzata da intensa infiammazione e nel carcinoma endometrioide dell’ovaio, valorizzando l’ipotesi che XBP1 possa rappresentare un marker di trasformazione neoplastica. In conclusione XBP1 ha un’alta espressione nell’endometrio sano, un tessuto costitutivamente secretivo, e poi gradualmente riduce la sua espressione nell’endometriosi e, in maniera più accentuata, nel carcinoma ovarico. Comprendere questi meccanismi potrebbe rappresentare uno step importante per una migliore definizione della patogenesi tumorale e per lo sviluppo in futuro di terapie geniche mirate.
The present study aims to analyze the activation profile of Unfolded Protein Response (UPR) related genes in endometriod ovarian carcinoma and to assess its possible involvement in the neoplastic transformation from endometriosis. The study was performed using different histological samples: endometrioid carcinoma of the ovary, healthy ovary, endometriosis cysts, eutopic endometrium from patients with endometriosis and healthy endometrium. From all the samples RNA was extracted and cDNA synthesis was performed by reverse transcription. cDNA was used for quantitative gene expression assays, made by Real Time PCR, analyzing genes belonging to the UPR pathway. Samples were divided into three groups: patients with endometriosis (n = 6), healthy patients (n = 6) patients with ovarian endometrioid carcinoma (n = 6). Statistical analysis performed was a t - test, testing the statistical differences, between data means from healthy patients (CTRL) and groups of patients with endometriosis (Ectopic and Eutopic) and patient with endometrioid carcinoma of the ovary (CA). We started analyzing the different expression of UPR pathway in endometrioid ovarian carcinoma compared to healthy ovary and we demonstrated an altered UPR gene expression in patients affected by endometrioid ovarian carcinoma, compared to healthy ovary. As a second step, we decided to analyze the UPR pathway genetic expression in the endometrioid ovarian carcinoma compared to the endometrium of healthy patients and of endometriosis patients. Our study shows a gradual reduction of XBP1 expression in endometriosis, characterized by intense inflammation, and endometrioid ovarian carcinoma, thus strengthening the hypothesis of XBP1 as a marker of neoplastic transformation. Conclusively XBP1s has a high basic expression in healthy endometrium, being a secretive tissue, then gradually decreases in endometriosis and to a higher degree, in ovarian carcinoma. Understanding these mechanisms could represent an important step, for a better definition of cancer pathogenesis, and also in the future, for the development of customized therapies.
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Overton, Caroline Elizabeth. "Endometriosis and pain." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321743.

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Ihlenfeld, Mauro Fernando Kürten [UNESP]. "Determinação de citocinas no diagnóstico laboratorial da endometriose peritoneal mínima e leve." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/103064.

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Made available in DSpace on 2014-06-11T19:32:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-08-10Bitstream added on 2014-06-13T19:02:56Z : No. of bitstreams: 1 ihlenfeld_mfk_dr_botfm.pdf: 6706392 bytes, checksum: 84cf4d5e562c51fba34d16bf95473913 (MD5)
Fundação para o Desenvolvimento Médico e Hospitalar (Famesp)
As dosagens da leptina, da interleucina-6 (IL-6) e do fator de necrose tumoral alfa (TNF-a) foram avaliadas no diagnóstico da endometriose peritoneal mínima e leve (estádios I e 11 - American Society for Reproductive Medicine). Participaram, deste estudo prospectivo e casocontrole, 29 mulheres, em idade reprodutiva, submetidas a videolaparoscopia. O grupo de estudo foi composto por 15 pacientes em investigação de esterilidade conjugal ou dor pélvica crônica (grupo E) e o grupo controle por 14 mulheres assintomáticas encaminhadas para realização de ligadura tubária (grupo C). Foram coletadas amostras de sangue periférico e líquido peritoneal para a dosagem laboratorial das citocinas determinadas por meio de testes ELlSA. No soro, não se observou diferenças significantes nas amostras de leptina, de IL-6 e do TNF-Q entre os grupos estudados (p>O,05). No líquido peritoneal, houve diferenças significantes nas dosagens da leptina e do TNF-Q entre os grupos estudados (pO,05). No líquido peritoneal, há evidências da possibilidade da utilização da leptina e do TNF-Q no diagnóstico da endometriose mínima ou leve, na amostra estudada.
The levels of leptin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-o) were evaluated as a diagnostic tool for minimal and mild peritoneal endometriosis (stages I and II - American Society for Reproductive Medicine). lhe subjects of this prospective, case-control study were 29 women of reproductive age, who underwent laparoscopy. Subjects of the study-group were 15 women under investigation of infertility or chronic pelvic pain (E-group) and controls were patients with no symptoms in which tubal ligation would be performed (C-group). In ali these patients were collected samples of peripheral blood and peritoneal f1uid, in order to determine cytokine levels employing ELlSA tests. There were no statistical differences of the sera on the studied groups concerning the levels of leptin, IL-6 and TNF-o (p> 0.05). There were statistical differences in the peritoneal fluid of the studied groups, concerning the levels of leptin and TNF-o (p< 0.05) but not for IL-6 (p> 0.05). There is an evidence of using leptin and TNF-o in the peritoneal f1uid as a diagnostic tool for minimal and mild endometriosis.
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Bell, Tanya Ann. "Risk factors for endometriosis /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19349.pdf.

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Lin, Jianghai. "Genetic Analysis of Endometriosis." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491192.

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Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still unclear. Accumulated evidence indicates that endometriosis has a heritable component. Recently, the International Endogene Study (IES) identified two significant linkage regions on chromosomes 7 and 10. The signal on chromosome 7 may be caused by a rare variant, with near-Mendelian inheritance, present in a subset of families. This thesis comprises follow-up studies aimed at: 1) narrowing down the linkage region on chromosome 7 through fine mapping and haplotype analyses; 2) screening candidate genes for mutations potentially responsible for the susceptibility to endometriosis through sequencing, and 3) conducting linkage analyses in two orthologous regions in a large, complex pedigree of rhesus monkeys with spontaneous disease. Firstly, linkage and haplotype analyses were conducted on 32 extended families, which contributed most to the linkage signal, from the Oxford dataset. Haplotype analyses narrowed down the linkage region to an area surrounding a single marker (D7S2251), containing 10 genes, although this result was dependent on a critical recombination in a single family. Secondly, fine mapping and haplotype analyses conducted to narrow an 11Mb region originally identified in the analysis of the combined IES dataset, identified a 1Mb region, comprising 5 genes, based on the haplotype segments shared between the affected members. The exons and part of the 5' untranslated regions ofINHBA, SFRP4 and HOXAlO were screened by TOCE and/or PCR-sequencing in affected members of the 32 Oxford families. Although some variants were identified, none of them were sufficiently frequent among cases to be responsible for the linkage signal in this group of women. Analyses were conducted in a 6-generational pedigree of 894 rhesus macaques residing at the Wisconsin National Primate Research Center, USA. Novel protocols were developed to extract DNA from paraffin-embedded tissues. Linkage analysis, conducted using Merlin and SimWalk2 on smaller sub-pedigrees, showed some evidence for linkage in both regions, particularly on chromosome 7, although results were not significant. The position of the linkage signals was close (2Mb and 500 kb) to the corresponding positions where the linkage signals had been found in humans. These results indicate that susceptibility genes to endometriosis might be located within the two regions. Possible studies following on from this thesis will include screening of more candidate genes in the linkage regions, re-sequencing of the linkage regions in humans, and performing a genome wide linkage analysis in the rhesus monkey model. Further investigations of biological pathways involved in endometriosis will lead to a better understanding of the aetiology of the disease, new treatments and improved patient quality of life.
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Waller, Kathleen Grace. "The nature of endometriosis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364148.

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coratti, francesco, and felice petraglia. "Endometriosis and bowel comorbidities." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1105403.

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Endometriosis is an estrogen-dependent gynecological condition characterized by the presence and growth of ectopic endometrial tissue, often associated with inflammation, severe and chronic pain, and infertility. Lesions are categorized as superficial peritoneal lesions, endometriomas, or deep infiltrating nodules, with high degree of individual variability in lesion color, size, and morphology. Numerous factors involved in this disease, including inflammation, angiogenesis, cytokine/chemokine expression, and endocrine alterations such as steroid and steroid receptor expression. When endometrial-like glands and stroma infiltrate the bowel wall, reaching at least the subserous fat tissue or the adjacent subserous plexus, the condition is diagnosed as intestinal endometriosis. Matherial and methods The aim of this study is to analyze the bowel comorbidities of the endometriosis. In particular, the frequency of endometriosis in young women with abdominal pain and to evaluate the most feared complication after surgery. In the first time, we consider the young fertile age women with right iliac fossa (RIF) pain . This is one of the most common complaint in those presenting at the emergency department and requiring acute care. A group of fertile age women (18-45 years) undergoing emergency surgery for acute RIF pain According to the intraoperative and pathology findings, patients were subdivided into 2 groups: group A was composed by those with histological diagnosis of endometriosis, whereas group B identified the controls. During the surgery, peritoneal samples were taken and analized. The present study showed that in women undergoing appendectomy for a RIF pain, superficial peritoneal endometriosis (SUP) is an incidental diagnosis in 23% of cases. In the second time, we consider the bowel endometriosis. When endometriosis infiltrate the bowel wall, reaching at least the subserous fat tissue or the adjacent subserous plexus, the condition is diagnosed as intestinal endometriosis Medical treatments include nonsteroidal anti-inflammatory drugs, oral contraceptives, progesterone, and gonadotropin-releasing hormone. Instead, surgical treatment includes shaving or resection. We performed this study with the aim of identifying the number of leaks in colonic resections for deep endometriosis. Conclusions Endometriosis is a very common condition in fertile young women. Knowing the degree of infiltration and deciding on the best treatment strategy should not be undervalued.
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Zimbardi, Daniela [UNESP]. "Identificação de perfis diferenciais de metilação do DNA na endometriose." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92429.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
A endometriose constitui uma doença de etiologia incerta, caracterizada pela presença de tecido endometriótico fora da cavidade uterina. E uma causa comum de morbidade, atingindo 5 a 10% das mulheres em idade reprodutiva. A metilção anormal na região promotora de genes especificos e os niveis de expressão alterados das DNA metiltransferases (DNMTs) compoem 0 conjunto de evidencias recentes indicando a endometriose como uma doença epigenetica. 0 presente estudo propos a investigaçao do perfil diferencial de metilaçao do DNA na endometriose, utilizando uma abordagem genomica de alta resoluçao baseada na metodologia de microarrays. Para isso, foram coletadas amostras pareadas de endometrio eutópico e de endometriose intestinal profunda de 18 pacientes. Foram selecionadas dez amostras pareadas para a hibridação do DNA: cinco casos foram submetidos ao enriquecimento das sequencias não metiladas (digerido com a enzima de restrição dependente de metilação McrBC ) e nove ao enriquecimento das sequencias metiladas (digerido com 0 coquetel de enzimas sensiveis a metilação do DNA Acil, HinP11, HpyCH41Ve Hpall). Os ensaios foram realizados em duplicatas totalizando 28 hibridações independentes na plataforma disponivel comercialmente Human CpG Island ChIP-on-Chip Set 244K (Agilent Technologies). Este protocolo foi previamente padronizada utilizando-se 0 DNA das linhagens derivadas de carcinomas de c610n HCT116 e DKO (celulas HCT116 duplo knockout para as DNMT1 e DNMT3b) usando marcação reversa (dye swap). Os dados foram avaliados nos software Agilent Technologies Genomic Workbench (DNA Analytics 5.0) e GeneSpring 7.3 (Agilent Technologies). Estre os 925 genes que apresentaram metila9ao diferencial, 55 foram recorrentes em dois ou mais casos. Varios destes genes mostram-se interessantes por exercerem funções relacionadas a fatores de transcrição (MSX1, EMX2, HOXB13, HOXD8 e HOXD9)...
Endometriosis is a disease of unknown etiology characterized by the presence of endometrial tissue outside the uterine cavity. It is a common cause of morbidity, affecting 5-10% of women in reproductive ages. The aberrant methylation in the promoter region of specific genes and the higher expression levels of DNA methyltransferases (DNMTs) in comparison with normal endometrium have been reported as evidences indicating that endometriosis is an epigenetic disease. The present study investigated the differential profile of DNA methylation in endometriosis using a high-resolution microarray-based assay. There were collected paired samples of eutopic endometrium and deep intestinal endometriosis from 18 patients and, subsequently, it was selected ten pairs to the DNA hybridization: five matched samples were submitted to the enrichment of unmethylated sequences (digested with the methylation-dependent restriction enzyme McrBG) and ten to the enrichment of methylated sequences (digested with the cocktail of enzymes sensitive to DNA methylation AGII, HinP1/, HpyGH4/V and Hpa/I). The assays were performed in duplicates totalizing 28 independent hybridizations in the commercially available platform Human CpG Island ChIP-on-Chip Set 244K (Agilent Technologies). The protocol was previously standardized using the DNA from the colon carcinomas cell lines HCT116 and DKO (HCT116 cells double-knockout for DNMT1 and DNMT3b) using reverse labeling (dye swap). The data were evaluated using the software Genomic Workbench (DNA Analytics 5.0) and GeneSpring 7.3. Among the 925 genes showing differential methylation, 55 genes were detected in at least two cases. Several of these gene could be considered good candidates to molecular biomarkers of endometriosis since that they act as transcription factors (MSX1, EMX2, HOXB13, HOXDB e HOXD9) , chromatin remodeling (MAD1L 1, WDR5 e BGOR)... (Complete abstract click electronic access below)
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Ihlenfeld, Mauro Fernando Kürten. "Determinação de citocinas no diagnóstico laboratorial da endometriose peritoneal mínima e leve /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/103064.

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Orientador: Rogério Dias
Banca: Jorge Nahás
Banca: Waldir Pereira Modotte
Banca: Reginaldo Guedes Coelho Lopes
Banca: Ilza Maria Urbano Monteiro
Resumo: As dosagens da leptina, da interleucina-6 (IL-6) e do fator de necrose tumoral alfa (TNF-a) foram avaliadas no diagnóstico da endometriose peritoneal mínima e leve (estádios I e 11 - American Society for Reproductive Medicine). Participaram, deste estudo prospectivo e casocontrole, 29 mulheres, em idade reprodutiva, submetidas a videolaparoscopia. O grupo de estudo foi composto por 15 pacientes em investigação de esterilidade conjugal ou dor pélvica crônica (grupo E) e o grupo controle por 14 mulheres assintomáticas encaminhadas para realização de ligadura tubária (grupo C). Foram coletadas amostras de sangue periférico e líquido peritoneal para a dosagem laboratorial das citocinas determinadas por meio de testes ELlSA. No soro, não se observou diferenças significantes nas amostras de leptina, de IL-6 e do TNF-Q entre os grupos estudados (p>O,05). No líquido peritoneal, houve diferenças significantes nas dosagens da leptina e do TNF-Q entre os grupos estudados (pO,05). No líquido peritoneal, há evidências da possibilidade da utilização da leptina e do TNF-Q no diagnóstico da endometriose mínima ou leve, na amostra estudada.
Abstract: The levels of leptin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-o) were evaluated as a diagnostic tool for minimal and mild peritoneal endometriosis (stages I and II - American Society for Reproductive Medicine). lhe subjects of this prospective, case-control study were 29 women of reproductive age, who underwent laparoscopy. Subjects of the study-group were 15 women under investigation of infertility or chronic pelvic pain (E-group) and controls were patients with no symptoms in which tubal ligation would be performed (C-group). In ali these patients were collected samples of peripheral blood and peritoneal f1uid, in order to determine cytokine levels employing ELlSA tests. There were no statistical differences of the sera on the studied groups concerning the levels of leptin, IL-6 and TNF-o (p> 0.05). There were statistical differences in the peritoneal fluid of the studied groups, concerning the levels of leptin and TNF-o (p< 0.05) but not for IL-6 (p> 0.05). There is an evidence of using leptin and TNF-o in the peritoneal f1uid as a diagnostic tool for minimal and mild endometriosis.
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Books on the topic "Endometriosis"

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W, Shaw Robert, ed. Endometriosis: Current understanding and management. Oxford: Blackwell Science, 1995.

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Chopra, Seema, ed. Endometriosis. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429448980.

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Amso, Nazar N., and Saikat Banerjee. Endometriosis. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780429488115.

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Gupta, Sajal, Avi Harlev, and Ashok Agarwal. Endometriosis. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18308-4.

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Giudice, Linda C., Johannes L. H. Evers, and David L. Healy, eds. Endometriosis. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444398519.

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Harada, Tasuku, ed. Endometriosis. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54421-0.

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Nezhat, Camran R., Gary S. Berger, Farr R. Nezhat, Veasy C. Buttram, and Ceana H. Nezhat, eds. Endometriosis. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4613-8404-5.

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A, Bruhat M., and Canis M, eds. Endometriosis. Basel: Karger, 1987.

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L, Olive David, ed. Endometriosis. Philadelphia: Saunders, 1997.

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A, Rock John, ed. Endometriosis. Philadelphia: Saunders, 1989.

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Book chapters on the topic "Endometriosis"

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Reid, Shannon, and George Condous. "Endometriomas and Pelvic Endometriosis." In Managing Ultrasonography in Human Reproduction, 123–36. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41037-1_7.

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Mettler, Liselotte, and Lara Valeska Maul. "Myths of Endometriosis: “Endometriomas”." In ISGE Series, 117–27. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23865-4_15.

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Ali, Oudai, and Nazar N. Amso. "Endometriosis:." In Endometriosis, 7–26. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780429488115-2.

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Brosens, Ivo, and Giuseppe Benagiano. "History of Endometriosis: A 20th-Century Disease." In Endometriosis, 1–18. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch1.

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Bobbio, Antonio, Diane Damotte, Anne Gompel, and Marco Alifano. "Extra-Abdominal Endometriosis." In Endometriosis, 108–14. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch10.

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Klemmt, Petra A. B., and Anna Starzinski-Powitz. "Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis." In Endometriosis, 115–29. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch11.

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Gargett, Caroline E., Hirotaka Masuda, and Gareth C. Weston. "Stem Cells in Endometriosis." In Endometriosis, 130–39. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch12.

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Winterhager, Elke. "Role of Steroid Hormones: Estrogen and Endometriosis." In Endometriosis, 140–44. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch13.

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Khanjani, Shirin, Marwa K. Al-Sabbagh, Luca Fusi, and Jan J. Brosens. "Role of Steroid Hormones: Progesterone Signaling." In Endometriosis, 145–52. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch14.

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Buck Louis, Germaine M. "Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals." In Endometriosis, 153–63. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781444398519.ch15.

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Conference papers on the topic "Endometriosis"

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Ferreira, Thaís de Almeida Silva, and Gabriela Halpern. "FATORES DE IMPACTO NA RESERVA OVARIANA E FERTILIDADE EM PACIENTES COM ENDOMETRIOSE." In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2728.

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Introdução: Endometriose é uma afecção inflamatória na qual o conteúdo endometrial acomete sítios além da cavidade uterina como ovários e órgãos pélvicos. É uma doença comum, crônica, heterogênea e pode ter a infertilidade como um dos seus sintomas, tendo implicações importantes na reserva ovariana, diminuindo as taxas de fertilização, implantação e gravidez. Objetivos: Fazer uma revisão bibliográfica sobre os fatores que relacionam a endometriose com os impactos na reserva ovariana e fertilidade feminina em relação ao número e qualidade de oócitos e embriões, em taxas de sucesso em tratamentos de fertilização in vitro e nos fatores de risco modificáveis como tabagismo, uso de álcool, níveis de vitamina D e indicação cirúrgica para excisão da endometriose. Material e Métodos: Foram reunidos 100 trabalhos científicos inseridos nas bases de dados do PubMed, Scielo e Google Acadêmico. As palavras-chaves utilizadas foram “endometriosis”, “endometriosis management” “ovarian reserve”, “fertility preservation”, “fertility impact”, “female fertility”, “laparoscopy” em inglês e português, utilizando os termos de busca booleanos "AND" e "OR" para mesclar os assuntos. Apenas revisões de literatura e revisões sistemáticas publicadas entre os anos 2000 e 2021, nos idiomas inglês e português (PT/BR), foram consideradas. Resultados: A qualidade oocitária é impactada pela presença da endometriose, a reserva ovariana é menor em portadoras de endometriomas do que em endometriose peritoneal, as taxas de sucesso em fertilização in vitro e a qualidade dos embriões gerados são dependentes da idade materna e as taxas de implantação, gravidez e nascidos-vivos são similares a outros grupos em tratamentos assistidos por outras causas de infertilidade. A laparoscopia para a remoção da endometriose é danosa à reserva ovariana e deve ser indicada quando há outros sintomas além da infertilidade. Mulheres com indicação cirúrgica podem se beneficiar da vitrificação de oócitos previamente à excisão endometriótica. Níveis insuficientes de vitamina D estão relacionados a maiores taxas de infertilidade associada à endometriose, os dados sobre uso de álcool são inconclusivos. Tabagismo não tem ação comprovada sobre a manifestação da endometriose. Conclusão: A endometriose tem impacto sobre a fertilidade feminina e seu manejo deve ser individualizado de acordo com os sintomas apresentados e o desejo reprodutivo da mulher.
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Guedes, Victoria Dias de Souza, and Vinícius Ribeiro Araujo Santos. "Revisão de estudos epidemiológicos sobre a endometriose no Brasil." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311081.

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Introdução: A endometriose é uma doença de grande prevalência e impacto social, e estima-se que cerca de 10% da população feminina seja portadora da doença. Objetivo: Rever a literatura brasileira produzida sobre a epidemiologia da endometriose até março de 2021, buscando o perfil da mulher brasileira com endometriose. Métodos: Foram utilizados os buscadores Scientific Electronic Library Online (SciELO) e PubMed. No primeiro, usou-se a palavra-chave “endometriose”, e foram encontrados 225 artigos. Desses, chegou-se ao total de três artigos sobre a epidemiologia no brasil. No segundo, com as palavras-chave “endometriosis epidemiology”, “endometriosis analysis”, “endometriosis panel” e “endometriosis incidence”, não foram localizados artigos sobre a epidemiologia da endometriose na população brasileira. Resultados: O estudo de Bellelis et al. (2010) analisou 892 pacientes submetidas à laparoscopia para confirmação histopatológica da doença. Nesse estudo, foi identificada a predominância de mulheres brancas (78,7%) e a média de idade de 33,2±6,3 anos. Observou-se umagrande quantidade de nulíparas (56,5%) e, das mulheres que tiveram filhos, cerca da metade com apenas uma prole. Também foi verificado que 69,5% das pacientes estavam casadas/amasiadas. Como principal sintoma referido pela paciente, obteve-se a dor pélvica crônica (56,8%). Em relação à queixa principal, a dismenorreia (62%) apareceu na frente, seguida de sintomas intestinais (48%). Em 2013 foram analisadas 230 pacientes por meio de corte transversal com intervenção realizada entre 2007 e 2011. A média de idade das mulheres foi de 38,3±10 anos. A maioria delas era parda, casada/amasiada, cursou ensino fundamental, dependente financeiramente, tinha índice de massa corpórea normal, até três filhos e atividade sexual ativa. Os exames físicos e a ultrassonografia foram normais na grande maioria dessas mulheres. Nas 41/230 laparoscopias realizadas, encontraram-se aderências (34%) e endometriose (29%), laqueadura tubária (50,4%) e cesariana (48,7%). A maior parte das pacientes tinha função intestinal normal (58,2%), com 38,3% de obstipação. Em um estudo descritivo retrospectivo que envolveu 237 mulheres entre 2011 e 2017, a maioria delas (65,4%) estava em idade reprodutiva (29-39 anos), com índice de massa corporal entre 18,5 e 24,9 kg/m2 e alta prevalência (23-81%) dos sintomas clínicos da doença, e 49,5% eram inférteis. O tempo médio de diagnóstico foi de cinco anos. O endometrioma ovariano e/ou endometriose profunda infiltrativa foram os tipos mais frequentes de endometriose (87%), e 59% das pacientes estavam no estágio ­III/­IV da doença. Oitenta e sete por cento das mulheres com diagnóstico cirúrgico tinham idade acima dos 30 anos, eram casadas (70%) e apresentavam menor paridade. Conclusão: São necessários mais estudos sobre a mulher brasileira que possui endometriose para melhor delinear seu perfil, auxiliando no diagnóstico precoce e no tratamento mais efetivo.
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Lazyrina, N. S., and E. YU Zaharchenko. "Ovarian Endometriosis." In SCIENCE OF RUSSIA: TARGETS AND GOALS. "Science of Russia", 2019. http://dx.doi.org/10.18411/sr-10-10-2019-15.

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Su, Ku-Min, Ping-Lin Hsieh, Jyun-Cheng Ke, Min-Hui Ho, Yao-Feng Li, and Chia-Ming Chang. "From endometriosis to endometrioid ovarian carcinoma: an integrated functionome based analysis." In ASGO 2023. Korea: Korean Society of Gynecologic Oncology, 2024. http://dx.doi.org/10.3802/jgo.2024.35.s1.0250.

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Medeiros, Ingrid Iana Fernandes, Ricardo Ney Oliveira Cobucci, Itamir de Morais Barroca Filho, Alef Emannuel Trigueiro Dias, Mariane Albuquerque Reisd, and Juliana Dantas de Araújo Santos Camargo. "Endometriosis intelligent application, aplicativo móvel: estudo de usabilidade com médicos." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311035.

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Introdução: Endometriose é uma das condições benignas mais comuns na ginecologia. Os padrões atualmente utilizados na sua investigação frequentemente resultam em um atraso prolongado entre o início dos sintomas e o diagnóstico. A saúde conta, atualmente, com o crescimento de tecnologias e aplicativos móveis que colaboram para a construção de uma nova modalidade de assistência, sendo essas pesquisas ainda incipientes no manejo de pacientes com endometriose e contribuindo para o subtratamento, a dor crônica e o impacto prolongado na qualidade devida das pacientes. Objetivo: O presente estudo avaliou a usabilidade entre médicos de um aplicativo móvel denominado de Endometriosis Intelligent Application (ENIA), criado para facilitar o diagnóstico clínico da endometriose. Métodos: Médicos especialistas e médicos residentes em Ginecologia e Obstetrícia de uma maternidade, localizada em Natal, estado do Rio Grande do Norte, Brasil, foram convidados a participar do estudo. O instrumento aplicado para avaliar a usabilidade foi o mHealth App Usability Questionnaire (MAUQ), um questionário já validado, traduzido para o português e projetado especificamente para aplicativos móveis. Resultados e conclusão: Ao todo, 15 médicos especialistas e 21 médicos residentes participaram da pesquisano período de julho a novembro de 2020. Sobre a confiabilidade geral do instrumento, a escala apresentou boa consistência interna determinada por um alfa de Cronbach de 0,871. Na análise das subescalas do MAUQ - facilidade de uso e satisfação, organização das informações no sistema e utilidade - os valores de alfa foram 0,80, 0,65 e 0,87, respectivamente. Foi verificada concordância máxima acima de 70% na maioria das questões da subescala de utilidade. Menores valores de concordância foram obtidos nos itens da subescala de arranjo das informações. Os médicos demonstraram satisfação e consideraram fácil a utilização do ENIA para auxiliar no diagnóstico da endometriose, contribuindo para que o aplicativo seja usado na prática desses profissionais no futuro.
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Praetorius, T. H., V. Lac, B. Tessier-Cloutier, T. M. Nazeran, M. Koebel, M. C. Mason, J. Senz, et al. "Is endometriosis metastasizing? Shared somatic alterations suggest common origins across endometriotic lesions." In Kongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). © 2020. Thieme. All rights reserved., 2020. http://dx.doi.org/10.1055/s-0040-1718045.

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Suryawanshi, Swati Maruti, Xin Huang, Raluca Budiu, SungHwan Kim, George Tseng, Esther Elishaev, Marcia Klein-Patel, et al. "Abstract 1653: Complement roles in endometriosis and endometriosis-associated ovarian cancer." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1653.

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Donnez, Jacques, Michelle Nisolle, Francoise Casanas-Roux, and Francoise Clerckx. "Endometriosis: rationale for surgery." In OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, edited by Christopher J. Daly, Warren S. Grundfest, Douglas E. Johnson, Raymond J. Lanzafame, Rudolf W. Steiner, Yona Tadir, and Graham M. Watson. SPIE, 1993. http://dx.doi.org/10.1117/12.146241.

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Zanlorenzi, Laís, Nelzi Ferreira de Queiroz Junior, Carlos Gomes Bezerra Sobrinh, Laura Vilas Boas, Renato Nishiara, and Thelma Skare. "ANTINUCLEAR ANTIBODIES IN ENDOMETRIOSIS." In SBR 2021 Congresso Brasileiro de Reumatologia. Sociedade Brasileira de Reumatologia, 2021. http://dx.doi.org/10.47660/cbr.2021.2009.

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Sangwan, Arushi. "MR Imaging Of Endometriosis." In Radiopaedia 2024 Virtual Conference. Radiopaedia.org, 2024. http://dx.doi.org/10.53347/rposter-2458.

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Reports on the topic "Endometriosis"

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Fatehchehr, Soorena, Maggie Jiang, and Susan Nasab. Urinary Tract Endometriosis: Literature from 1976 to 2023. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2024. http://dx.doi.org/10.37766/inplasy2024.2.0054.

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Timkova, Vladimira, Pavol Mikula, Zuzana Katreniakova, Jeremy Howick, and Iveta Nagyova. Assessing healthcare needs in endometriosis: a scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2024. http://dx.doi.org/10.37766/inplasy2024.3.0109.

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Chen, Peng, and Chi-Yuan Zhang. Association between endometriosis and prognosis of ovarian cancer: an updated meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0109.

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Vanhie, Arne, Ellen Caron, Eveline Vermeersch, Dorien O, Carla Tomassetti, Christel Meuleman, Pieter Mestdagh, and Thomas D'Hooghe. Circulating microRNAs as non-invasive biomarkers in endometriosis diagnosis – a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2024. http://dx.doi.org/10.37766/inplasy2024.1.0066.

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Chakraborty, Payel, and Tamilvanan Shunmugaperumal. Simvastatin repurposing towards endometriosis management: The use of self -nanoemulsifying drug delivery system. Peeref, April 2023. http://dx.doi.org/10.54985/peeref.2304p6131285.

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Su, Yang, Xiaoyan Zheng, Hao Zhu, Yan Jia, and Jie Yang. A network meta-analysis of different acupuncture and moxibustion methods for the treatment of endometriosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2023. http://dx.doi.org/10.37766/inplasy2023.8.0077.

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Wang, Dong-wei. Effect of melatonin for the management of endometriosis: a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0093.

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Zhang, ZY, J. Wang, YL Fan, BY Wang, and Wei-ting Zhang. Effectiveness of neuromuscular electrical stimulation for endometriosis-related pain: a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0191.

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Lin, Shaochong, Xinyue Wang, Xiling Fu, Wenhui Yang, Yang Bai, Zhongna Shi, Junpeng Du, and Baojin Wang. Efficacy and safety of dienogest for the treatment of endometriosis and adenomyosis: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2020. http://dx.doi.org/10.37766/inplasy2020.5.0107.

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Ma, Li, bingxin wen, and zhenhua Wen. A systematic-review and meta-analysis of the efficacy of uterine artery embolization in the treatment of endometriosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0071.

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You might also be interested in the extended bibliographies on the topic 'Endometriosis' for particular source types:
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