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Journal articles on the topic 'Endogenous P2P market'

Author: Grafiati

Published: 22 February 2025

Last updated: 31 July 2025

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1

Aleksin, Glib O., Svitlana V. Usherenko, Andrii S. Gryshchuk, and Oleksandr V. Kosko. "Fintech Solutions in Shaping Capital Structure under Conditions of Intensified Uncertainty at Micro and Macro Levels." Business Inform 4, no. 567 (2025): 395–404. https://doi.org/10.32983/2222-4459-2025-4-395-404.

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In the context of increasing uncertainty at both micro and macro levels caused by exogenous and endogenous crises, the significance of making strategic decisions in corporate finance, particularly regarding the optimization of capital structure, is heightened. The aim of this article is to analyze the features of capital structure formation influenced by fintech solutions in the context of growing uncertainty from both theoretical and empirical perspectives. The article examines both the theoretical and practical aspects of the impact of fintech solutions on the formation of enterprises’ capit

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Garriga, Carlos, Aaron Hedlund, Yang Tang, and Ping Wang. "Rural-Urban Migration, Structural Transformation, and Housing Markets in China." American Economic Journal: Macroeconomics 15, no. 2 (2023): 413–40. http://dx.doi.org/10.1257/mac.20160142.

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This paper investigates the interrelationship between urbanization, structural transformation, and the post-2000 Chinese housing boom through the lens of a dynamic spatial equilibrium model that features migration and a rich housing market structure with mortgages. Urbanization and structural transformation emerge as key drivers of China's house price boom, while at the same time rising house prices impede these forces of economic transition. Policies to boost urbanization can be undone by the endogenous price response. Land supply expansion ameliorates this negative feedback. Overall, housing

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Zhang, Jie Lin, Clyde S. Crumpacker, and David T. Scadden. "Primitive Hematopoietic Cells Resist HIV-1 Infection Via P21Waf1/Cip1/Sdi1." Blood 108, no. 11 (2006): 490. http://dx.doi.org/10.1182/blood.v108.11.490.490.

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Abstract Hematopoietic stem cells are resistant to HIV-1 infection. We have identified a novel mechanism by which the cyclin-dependent kinase inhibitor, p21Waf1/Cip1/Sdi1 (p21), known for its regulation of stem cell pool size (1,2), restricts HIV-1 infection of primitive hematopoietic cells in a non-cell cycle dependent manner. Knocking down p21 by siRNA increased HIV-1 infection and induction of p21 expression by phorbol ester (TPA) blocked HIV-1 replication. P21 did not affect the overall levels of cDNA synthesis, but significantly blocked viral integration and resulted in marked increase in

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4

Kurhan, Faruk, Gulsum Zuhal Kamis, Hamit Hakan Alp, Emine Fusun Akyuz Cim, and Abdullah Atli. "A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels in Obsessive Compulsive Disorder." Psychiatry and Clinical Psychopharmacology 32, no. 3 (2022): 215–21. http://dx.doi.org/10.5152/pcp.2022.21318.

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Funato, Noriko, Kiyoshi Ohtani, Kimie Ohyama, Takayuki Kuroda, and Masataka Nakamura. "Common Regulation of Growth Arrest and Differentiation of Osteoblasts by Helix-Loop-Helix Factors." Molecular and Cellular Biology 21, no. 21 (2001): 7416–28. http://dx.doi.org/10.1128/mcb.21.21.7416-7428.2001.

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ABSTRACT Cellular differentiation entails the coordination of cell cycle arrest and tissue-specific gene expression. We investigated the involvement of basic helix-loop-helix (bHLH) factors in differentiation of osteoblasts using the human osteoblastic cell line MG63. Serum starvation induced growth arrest at G1 phase, accompanied by expression of cyclin-dependent kinase inhibitor p21WAF1/Cip1. Reporter assays with the p21 gene promoter demonstrated that the combination of E2A (E12 or E47) and coactivator CBP was responsible for p21 induction independent of p53. Twist inhibited E2A-CBP-depende

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Morgan, E. L., M. V. Hobbs, and W. O. Weigle. "Lymphocyte activation by the Fc region of immunoglobulin. I. Role of prostaglandins in the down regulation of Fc fragment-induced polyclonal antibody production." Journal of Immunology 134, no. 4 (1985): 2247–53. http://dx.doi.org/10.4049/jimmunol.134.4.2247.

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Abstract Fc fragment-, subfragment-, and p23-induced polyclonal antibody production are regulated by endogenous and exogenous PGE. Addition of the PG synthetase inhibitor indomethacin (IM) to murine spleen cell cultures resulted in a significant increase in the amount of Ig secreted. Moreover, addition of exogenous PGE to culture resulted in a marked suppression of IgM and IgG secretion. Splenic adherent macrophages and P388D1 cells release PGE upon stimulation with Fc fragments, subfragments, and p23. The inclusion of IM or aspirin in culture was found to abrogate the ability of Fc fragments

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Bhaskar, V. "Sex Selection and Gender Balance." American Economic Journal: Microeconomics 3, no. 1 (2011): 214–44. http://dx.doi.org/10.1257/mic.3.1.214.

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We model the equilibrium sex ratio when parents can choose the sex of their child. With intrinsic son preference, sex selection results in a male-biased sex ratio. This is inefficient due to a marriage market congestion externality. Medical innovations that facilitate selection aggravate the inefficiency. If son preference arises endogenously, due to population growth causing an excess supply of women on the marriage market, selection may improve welfare. Empirically, sex selection causes an excess of males and reduces welfare in China. In most parts of India, cohort sizes are growing, implyin

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Chen, Yi-Cheng, Pin-Yu Kuo, Yu-Chi Chou, et al. "Up-Regulated Expression of Pro-Apoptotic Long Noncoding RNA lincRNA-p21 with Enhanced Cell Apoptosis in Lupus Nephritis." International Journal of Molecular Sciences 22, no. 1 (2020): 301. http://dx.doi.org/10.3390/ijms22010301.

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Accelerated cell apoptosis with dysregulated long noncoding RNAs is the crucial pathogenesis in lupus nephritis (LN). Pro-apoptotic lincRNA-p21 was studied in LN patients, cell lines with lentivirus-mediated overexpression and CRISPR interference (CRISPRi)-conducted repression, and a mouse model. Clinical samples were from patients and age/sex-matched controls. Expression of lincRNA-p21 and endogenous RNA target miR-181a, were examined in mononuclear and urine cells. Guide RNA sequences targeting lincRNA-p21 were cloned into CRISPRi with dCas9/ Krüppel-associated box (KRAB) domain. LincRNA-p21

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9

Luque, Raul M., Beatriz S. Soares, Xiao-ding Peng, et al. "Use of the Metallothionein Promoter-Human Growth Hormone-Releasing Hormone (GHRH) Mouse to Identify Regulatory Pathways that Suppress Pituitary Somatotrope Hyperplasia and Adenoma Formation due to GHRH-Receptor Hyperactivation." Endocrinology 150, no. 7 (2009): 3177–85. http://dx.doi.org/10.1210/en.2008-1482.

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Hyperactivation of the GHRH receptor or downstream signaling components is associated with hyperplasia of the pituitary somatotrope population, in which adenomas form relatively late in life, with less than 100% penetrance. Hyperplastic and adenomatous pituitaries of metallothionein promoter-human GHRH transgenic (Tg) mice (4 and &gt; 10 months, respectively) were used to identify mechanisms that may prevent or delay adenoma formation in the presence of excess GHRH. In hyperplastic pituitaries, expression of the late G1/G2 marker Ki67 increased, whereas the proportion of 5-bromo-2′-deoxyur

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Lisetska, I. S., and M. M. Rozhko. "Determination of endogenous intoxication in teenagers and young adults who smoke." UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, no. 2(90) (June 30, 2022): 39–43. http://dx.doi.org/10.15574/pp.2022.90.39.

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The harmful habit of smoking is an urgent and important socio-medical problem that has become an epidemic, including in Ukraine. It is a matter of concern that more than 500,000 young people join this bad habit every year. Today, smoking is a modified risk factor for the formation and progression of many diseases, including dental pathology among different age groups, especially among teenagers and young adults. The oral cavity is the first barrier to tobacco smoke with toxins and carcinogens that are part of it. It is known that the pathogenesis of many diseases is accompanied by a nonspecifi

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Dharmawardhane, Suranganie, Luraynne C. Sanders, Stuart S. Martin, R. Hugh Daniels, and Gary M. Bokoch. "Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells." Journal of Cell Biology 138, no. 6 (1997): 1265–78. http://dx.doi.org/10.1083/jcb.138.6.1265.

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The mechanisms through which the small GTPases Rac1 and Cdc42 regulate the formation of membrane ruffles, lamellipodia, and filopodia are currently unknown. The p21-activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts, suggesting that they may play a role in mediating the effects of these GTPases on cytoskeletal dynamics. We have examined the subcellular localization of endogenous PAK1 in fibroblast cell lines using specific PAK1 antibodies. PAK1 is detected in submembranous vesicles

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Burdick, Ryan, Jessica L. Smith, Chawaree Chaipan, et al. "P Body-Associated Protein Mov10 Inhibits HIV-1 Replication at Multiple Stages." Journal of Virology 84, no. 19 (2010): 10241–53. http://dx.doi.org/10.1128/jvi.00585-10.

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ABSTRACT Recent studies have shown that APOBEC3G (A3G), a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, is localized to cytoplasmic mRNA-processing bodies (P bodies). However, the functional relevance of A3G colocalization with P body marker proteins has not been established. To explore the relationship between HIV-1, A3G, and P bodies, we analyzed the effects of overexpression of P body marker proteins Mov10, DCP1a, and DCP2 on HIV-1 replication. Our results show that overexpression of Mov10, a putative RNA helicase that was previously reported to belong to the

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Dhyani, Anamika, Patricia Favaro, and Sara T. Olalla Saad. "ANKHD1 Is Essential for Repair of DNA Double-Strand Breaks in Multiple Myeloma." Blood 126, no. 23 (2015): 1762. http://dx.doi.org/10.1182/blood.v126.23.1762.1762.

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Abstract ANKHD1, Ankyrin repeat and KH domain-containing protein is highly expressed and plays an important role in the proliferation and cell cycle progression of multiple myeloma (MM) cells. Inhibition of ANKHD1 expression upregulates p21 (CDKN1A, Cyclin Dependent Kinase Inhibitor), a potent cell cycle regulator, and its expression represses p21 promoter. Upregulation of p21 was found to be irrespective of the TP53 mutational status of MM cell lines. A study by our group has shown that ANKHD1 is highly expressed in S phase and that the inhibition of ANKHD1 expression downregulates replicatio

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Jane, Stephen, Quan Zhao, Gerhard Rank, Loretta Cerruti, David J. Curtis, and John M. Cunningham. "The Protein Methyltransferase Prmt5 Links Histone H4 Methylation to Dnmt3a-Dependent DNA Methylation and Transcriptional Silencing of the Fetal Globin Genes." Blood 108, no. 11 (2006): 361. http://dx.doi.org/10.1182/blood.v108.11.361.361.

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Abstract Elevated levels of fetal hemoglobin ameliorate the severity of sickle cell disease and β-thalassemia, fuelling interest in the mechanisms underpinning the fetal (γ) to adult (β) switch in β-like globin chain subtype. We have previously identified a tripartite protein complex consisting of p22 NF-E4, CP2 and ALY, collectively known as the stage selector protein (SSP) that binds to the proximal γ-promoters, and fosters the preferential expression of the γ-genes in fetal erythroid cells. We have also identified a 14 kDa isoform of the NF-E4 protein that plays a role in γ-gene repression

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Poudel, Arati N., Rebekah E. Holtsclaw, Athen Kimberlin, et al. "12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis." Plant and Cell Physiology 60, no. 10 (2019): 2152–66. http://dx.doi.org/10.1093/pcp/pcz109.

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Abstract 12-hydroxy-jasmonoyl-isoleucine (12OH-JA-Ile) is a metabolite in the catabolic pathway of the plant hormone jasmonate, and is synthesized by the cytochrome P450 subclade 94 enzymes. Contrary to the well-established function of jasmonoyl-isoleucine (JA-Ile) as the endogenous bioactive form of jasmonate, the function of 12OH-JA-Ile is unclear. Here, the potential role of 12OH-JA-Ile in jasmonate signaling and wound response was investigated. Exogenous application of 12OH-JA-Ile mimicked several JA-Ile effects including marker gene expression, anthocyanin accumulation and trichome induct

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Cocoradă, Elena. "Anxiety with and Without New Technology Among Romanian High School Students." European Journal of Interdisciplinary Studies 3, no. 3 (2017): 22. http://dx.doi.org/10.26417/ejis.v3i3.p22-30.

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Nowadays, the new technology defines the classroom and students’ and teachers’ life. Sometimes the attitude towards technology use is marked by negative dysfunctional emotion, anxiety, fear, avoidance or dependence. This paper focuses both on the anxiety with the new technology and on the anxiety without technology. Our research aims to examine the attitudes and behaviours of Romanian high school students regarding trendy technologies, such as computers, internet and smartphones, including the access to social networking applications. The following tools were used: CARS (Heinssen, Glass, - Kni

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Cocoradă, Elena. "Anxiety with and Without New Technology Among Romanian High School Students." European Journal of Interdisciplinary Studies 8, no. 1 (2017): 22. http://dx.doi.org/10.26417/ejis.v8i1.p22-30.

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Nowadays, the new technology defines the classroom and students’ and teachers’ life. Sometimes the attitude towards technology use is marked by negative dysfunctional emotion, anxiety, fear, avoidance or dependence. This paper focuses both on the anxiety with the new technology and on the anxiety without technology. Our research aims to examine the attitudes and behaviours of Romanian high school students regarding trendy technologies, such as computers, internet and smartphones, including the access to social networking applications. The following tools were used: CARS (Heinssen, Glass, - Kni

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18

Contreras-Jurado, Constanza, Laura García-Serrano, Mariana Gómez-Ferrería, Clotilde Costa, Jesús M. Paramio, and Ana Aranda. "The Thyroid Hormone Receptors as Modulators of Skin Proliferation and Inflammation." Journal of Biological Chemistry 286, no. 27 (2011): 24079–88. http://dx.doi.org/10.1074/jbc.m111.218487.

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We have analyzed the role of the thyroid hormone receptors (TRs) in epidermal homeostasis. Reduced keratinocyte proliferation is found in interfollicular epidermis of mice lacking the thyroid hormone binding isoforms TRα1 and TRβ (KO mice). Similar results were obtained in hypothyroid animals, showing the important role of the liganded TRs in epidermal proliferation. In addition, KO and hypothyroid animals display decreased hyperplasia in response to 12-O-tetradecanolyphorbol-13-acetate. Both receptor isoforms play overlapping functional roles in the skin because mice lacking individually TRα1

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Guo, Luming, Xiaoling Xie, Jing Wang, et al. "Inducible Rbpms-CreERT2 Mouse Line for Studying Gene Function in Retinal Ganglion Cell Physiology and Disease." Cells 12, no. 15 (2023): 1951. http://dx.doi.org/10.3390/cells12151951.

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Retinal ganglion cells (RGCs) are the sole output neurons conveying visual stimuli from the retina to the brain, and dysfunction or loss of RGCs is the primary determinant of visual loss in traumatic and degenerative ocular conditions. Currently, there is a lack of RGC-specific Cre mouse lines that serve as invaluable tools for manipulating genes in RGCs and studying the genetic basis of RGC diseases. The RNA-binding protein with multiple splicing (RBPMS) is identified as the specific marker of all RGCs. Here, we report the generation and characterization of a knock-in mouse line in which a P2

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Ricketts, M. H., and A. D. Levinson. "High-level expression of c-H-ras1 fails to fully transform rat-1 cells." Molecular and Cellular Biology 8, no. 4 (1988): 1460–68. http://dx.doi.org/10.1128/mcb.8.4.1460-1468.1988.

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Rat-1 cells were transfected with plasmids encoding normal (Gly-12), nonactivated (Pro-12), and activated (Val-12 and Ile-12) p21H-ras in the presence of an amplifiable dihydrofolate reductase marker. The introduced DNA was amplified by selection in methotrexate to establish the relationship between p21H-ras expression and various hallmarks of cellular transformation. The maximum level of p21H-ras (Gly-12) consistent with cell viability was approximately 0.13% of total cell protein (approximately 60,000 molecules per cell); this is 44-fold greater than the level of the endogenous protein. The

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Suwannakot, Kornrawee, Nataya Sritawan, Salinee Naewla, et al. "Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex." Oxidative Medicine and Cellular Longevity 2022 (July 15, 2022): 1–13. http://dx.doi.org/10.1155/2022/1596362.

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Previous studies have revealed that the side effects of anticancer drugs induce a decrease of neurogenesis. Methotrexate (MTX), one of anticancer drugs, can induce lipid peroxidation as an indicator of oxidative stress in the brain. Melatonin has been presented as an antioxidant that can prevent oxidative stress-induced neuronal damage via the activation of antioxidant enzymes associated with the increase of neurogenesis. The aims of the present study are to examine the neuroprotective effect of melatonin on the neurotoxicity of MTX on neurogenesis and the changes of protein expression and ant

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Ricketts, M. H., and A. D. Levinson. "High-level expression of c-H-ras1 fails to fully transform rat-1 cells." Molecular and Cellular Biology 8, no. 4 (1988): 1460–68. http://dx.doi.org/10.1128/mcb.8.4.1460.

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Rat-1 cells were transfected with plasmids encoding normal (Gly-12), nonactivated (Pro-12), and activated (Val-12 and Ile-12) p21H-ras in the presence of an amplifiable dihydrofolate reductase marker. The introduced DNA was amplified by selection in methotrexate to establish the relationship between p21H-ras expression and various hallmarks of cellular transformation. The maximum level of p21H-ras (Gly-12) consistent with cell viability was approximately 0.13% of total cell protein (approximately 60,000 molecules per cell); this is 44-fold greater than the level of the endogenous protein. The

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Pilunov, Artem, Dmitrii Romaniuk, Savely Sheetikov, et al. "Development of T-Cell Therapy Targeting Hematopoietic Minor Histocompatibility Antigen HA-1." Blood 134, Supplement_1 (2019): 5749. http://dx.doi.org/10.1182/blood-2019-130552.

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the only curative therapy for hematological malignancies yet in nearly one-third of patients, it is followed by a relapse of the disease contributing to high mortality. In fully HLA-matched allo-HSCT graft versus leukemia reaction is driven by the recognition of the minor histocompatibility antigens (MiHAs) - endogenous polymorphic peptides presented by MHC. Particularly, HA-1 MiHA is a promising target for immunotherapy. HA-1 is presented by frequent among Caucasians HLA allele - A*02:01. The single nucleotide variati

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Crozier, Stephen J., Maria Dolors Sans, Charles H. Lang, Louis G. D'Alecy, Stephen A. Ernst, and John A. Williams. "CCK-induced pancreatic growth is not limited by mitogenic capacity in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 5 (2008): G1148—G1157. http://dx.doi.org/10.1152/ajpgi.00426.2007.

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In mice fed trypsin inhibitor (camostat) to elevate endogenous CCK, pancreatic growth plateaus by 7 days. It is unknown whether this represents the maximum growth capacity of the pancreas. To test the ability of CCK to drive further growth, mice were fed chow containing camostat (0.1%) for 1 wk, then fed standard chow for 1 wk, and finally returned to the camostat diet for a week. Pancreatic mass increased to 245% of initial value (iv) following 1 wk of camostat feeding, decreased to 147% iv following a 1 wk return to normal chow, and increased to 257% iv with subsequent camostat feeding. Camo

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Zhang, Shengliang, and Wafik S. El-Deiry. "Abstract 2604: Functional analysis of p53 codon 72 polymorphism with cysteine substitution in cancer cells." Cancer Research 83, no. 7_Supplement (2023): 2604. http://dx.doi.org/10.1158/1538-7445.am2023-2604.

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Abstract The p53 codon p72 polymorphism with proline (p53P72)/arginine (p53R72) substitution is associated with cancer incidence. Cysteine(C) substitution at p53 codon 72 polymorphism (p53C72) is rarely studied in cancer patients. A patient who developed AML and who carries p53C72 was described (El-Deiry, 2022 WIN Symposium). The patient’s family has high rates of cancer susceptibility in the women some of whom carry FANCC alterations and other alleles. To examine the functional characteristics of different p53 alterations at codon 72, we generated plasmids expressing p53C72, p53 R72 or p53P72

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Vega, Francisco, L. Jeffrey Medeiros, Coralyn Atwell, et al. "Activation of mTOR Signaling Pathway Contributes to Tumoral Cell Survival in ALK-Positive Anaplastic Large Cell Lymphoma." Blood 106, no. 11 (2005): 2419. http://dx.doi.org/10.1182/blood.v106.11.2419.2419.

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Abstract Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) frequently carries the t(2;5)(p23;q35) resulting in aberrant expression of nucleophosmin (NPM)-ALK. Previously, NPM-ALK has been shown to activate phosphatidylinositol 3-kinase (PI3K) and its downstream effector, the serine/threonine kinase AKT. Recently, we have shown that mTOR signaling proteins are activated in ALK-positive ALCL tumors and that mTOR activation depends, at least in part, on activation of AKT (Lab Invest2005; 85: 255A). In this study, we investigate the biological effects of inhibition of

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Liu, W., Q. LI, X. Han, L. Sun, and J. Wang. "POS0413 IGURATIMOD AMELIORATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS VIA INHIBITINGEMT PROCESS AND NLRP3 INFLAMMASOME ACTIVATION." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 462.3–462. http://dx.doi.org/10.1136/annrheumdis-2022-eular.969.

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BackgroundInterstitial pulmonary fibrosis is the deadliest manifestation of rheumatoid arthritis (RA), and its pathogenesis is complicated. As a new drug for controlling RA, clinical studies have found that iguratimod (IGU) has certain advantages in improving lung function and shows great potential for pulmonary fibrosis therapy[1]. However, the specific mechanism of IGU in treating pulmonary fibrosis is not clear.ObjectivesThis study was designed to observe and investigate the therapeutic effects of IGU on bleomycin-induced pulmonary fibrosis in mice and further investigate its underlying mec

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Peery, Robert Craig, Jiejun Shi, Leah Farmer, et al. "Abstract 6016: A comprehensive analysis of gut microbiome mediated epigenetic regulation of intestinal stem cells." Cancer Research 83, no. 7_Supplement (2023): 6016. http://dx.doi.org/10.1158/1538-7445.am2023-6016.

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Abstract Background: Gut microbial colonization, represents a critical time period for establishing the overall health of an individual. The intestine is a highly dynamic tissue with high turnover of intestinal epithelial cells throughout the life span of an individual making intestinal stem cells (ISCs) critical for normal gut homeostasis. Currently, there exists a lack of knowledge in how the gut microbiota regulates DNA methylation to influence the behavior of these ISCs. Aberrant DNA methylation is now documented to be critical in the disease pathogenesis of intestinal disorders such as co

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Oh, Hyeon Jeong, Seah Park, Hong-Kyung Yang, et al. "Abstract 5252: Salsolinol suppresses the STAT3-EMT axis in liver carcinogenesis." Cancer Research 83, no. 7_Supplement (2023): 5252. http://dx.doi.org/10.1158/1538-7445.am2023-5252.

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Abstract Liver cancer is one of the most common malignancies and a leading cause of death worldwide. However, it is still very difficult to treat and prevent liver cancer. Salsolinol (SAL) is an endogenous catechol isoquinoline generated by the condensation of dopamine with acetaldehyde, a major metabolite of ethanol. In the present study, we found that SAL inhibited the phosphorylation, dimerization, and subsequent nuclear translocation of STAT3 in a concentration-dependent manner in SK-Hep1 cells, a hepatic carcinoma cell line. SAL suppressed the expression of Cdk 4 and Cyclin D1, the major

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Qian, Hong, and Mikael Sigvardsson. "Early B-Cell Factor 2 Represents A Novel Marker of Highly Purified Messenchymal Stem-Like Cells in Mouse Bone Marrow." Blood 114, no. 22 (2009): 252. http://dx.doi.org/10.1182/blood.v114.22.252.252.

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Abstract Abstract 252 The future therapeutic use of mesenchymal stem cells (MSCs) for human depends on the establishment of preclinical studies with other mammals such as mouse. However, purification and characterization of mouse MSCs from bone marrow (BM) remain poorly documented. The lack of MSC-specific markers for isolation and characterization has been a main obstacle to both research and clinical application with MSCs. The isolation method based on the adherence properties of MSCs in culture has proven ineffective because of large contamination of various hematopoietic lineages and poten

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Suzuki, Naoya, Asuka Hira, Akira Niwa, et al. "Mesodermal Development From Reprogrammed Fanconi Anemia Cells Is Affected by ALDH2 Enzymatic Activity." Blood 120, no. 21 (2012): 648. http://dx.doi.org/10.1182/blood.v120.21.648.648.

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Abstract Abstract 648 Introduction Fanconi anemia (FA) is a genome instability disorder with clinical characteristics including progressive bone marrow failure (BMF), developmental abnormalities, and increased occurrence of leukemia and cancer. To date 15 genes have been implicated in FA, and their products form a common DNA repair network often referred to as “FA pathway”. Following DNA damage or replication stress, the FA pathway is activated, leading to the monoubiquitination of FANCD2 and FANCI proteins (the ID complex). The monoubiquitinated ID complex is loaded on damaged chromatin with

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Kurlekar, Samvid, Joanna D. C. Lima, Chris W. Pugh, Julie Adam, and Peter J. Ratcliffe. "Abstract 862: Negative cellular outcomes following acute in vivo Vhl inactivation in mice." Cancer Research 82, no. 12_Supplement (2022): 862. http://dx.doi.org/10.1158/1538-7445.am2022-862.

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Abstract Clear cell renal cell carcinoma (ccRCC) is driven by the biallelic inactivation of the von Hippel Lindau tumor suppressor (VHL) gene, which results directly in the normoxic stabilization of hypoxia inducible factors (HIF-1 and -2). While VHL is expressed ubiquitously, its inactivation is tumorigenic only in specific tissues. We hypothesize that this tissue-specificity arises from a negative selective pressure on VHL KO cells that is tolerated in certain contexts. To assess this phenomenon, we induced Vhl deletion in vivo simultaneously across the mouse body and observed cell fate with

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Cho, Hearn J., Anna Mei, Tricia Nardiello, et al. "MAGE-A3 Inhibits p53 and Promotes Proliferation and Survival in Multiple Myeloma." Blood 114, no. 22 (2009): 1795. http://dx.doi.org/10.1182/blood.v114.22.1795.1795.

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Abstract Abstract 1795 Poster Board I-821 The type I Melanoma Antigen GEne (MAGE) proteins MAGE-A3 and CT7 (MAGE-C1) were commonly detected in primary tumor cells from multiple myeloma patients and their expression was correlated with advanced disease and proliferation. They belong to the Cancer-Testis antigen (CTAg) family of tumor-associated proteins. In gene expression analyses of primary myeloma cells, CTAg were associated with proliferative gene signatures and poor clinical outcome. These findings suggest that type I MAGE may play a pathogenic role in proliferation or survival in multiple

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Grasshoff, H., S. Comduehr, J. Ohmes, et al. "POS0875 AUTOANTIBODIES DIRECTED TO G-PROTEIN COUPLED RECEPTORS CORRELATE WITH DISEASE ACTIVITY SCORES IN PATIENTS WITH PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 743.2–744. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6068.

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BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory disease that affects the skin, nails, tendons and joints. In addition, several comorbidities have been identified with PsA. In particular, a frequent occurrence of fatigue and mental disorders such as depression have been described in patients with PsA. Key cellular players in pathophysiology of PsA are T cells. However, in recent years, various autoantibodies such as anti-LL37 and anti-Pso-p27 have been identified in PsA as well [1]. Autoantibodies targeting G protein-coupled receptors (GPCRs) have been identified in several diseas

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Zheng, Boshen, Yue Fan, Wei Wei, Yourui Xu, Shaowei Huang, and Shengwei Mei. "Distribution Optimal Power Flow With Energy Sharing Via a Peer-To-Peer Transactive Market." Frontiers in Energy Research 9 (July 15, 2021). http://dx.doi.org/10.3389/fenrg.2021.701149.

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The technology advancement and cost decline of renewable and sustainable energy increase the penetration of distributed energy resources (DERs) in distribution systems. Transactive energy helps balance the local generation and demand. Peer-to-peer (P2P) energy trading is a promising business model for transactive energy. Such a market scheme can increase the revenue of DER owners and reduce the waste of renewable energy. This article proposes an equilibrium model of a P2P transactive energy market. Every participant seeks the maximum personal interest, with the options of importing or providin

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Zennyo, Yusuke. "Product variety and design in the age of peer‐to‐peer sharing." Journal of Economics & Management Strategy, November 6, 2023. http://dx.doi.org/10.1111/jems.12563.

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AbstractThe rise of peer‐to‐peer (P2P) sharing, exemplified recently by increased car‐sharing and clothing‐sharing, has altered our consumption style. One can consume goods without owning them. In fact, the ownership of goods can be monetized through P2P rental markets. These changes are regarded as influencing various strategies of manufacturers of goods being shared. Specifically, this paper examines aspects of product variety and design. A stylized model is examined in which a manufacturing firm makes a product variety decision of whether to launch a niche product line in addition to an exi

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Tang, Han, Li-Hang Chen, and Jiří Friml. "Auxin fluctuation and PIN polarization in moss leaf cell reprogramming." Plant And Cell Physiology, January 18, 2025. https://doi.org/10.1093/pcp/pcaf008.

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Abstract Auxin and its PIN-FORMED (PIN) exporters are essential for tissue repair and regeneration in flowering plants. To gain insight into the evolution of this mechanism, we investigated their roles in leaves excised from Physcomitrium patens, a bryophyte known for its remarkable cell reprogramming capacity. We used various approaches to manipulate auxin levels, including exogenous application, pharmacological manipulations, and auxin biosynthesis mutants. We observed no significant effect on the rate of cell reprogramming. Rather, our analysis of auxin dynamics revealed a decrease in auxin

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Caruso, German, Lautaro Chittaro, Maria Emilia Cucagna, and Luis Pedro Espana. "From bad to worse: The economic impact of COVID-19 in developing countries. Evidence from Venezuela." Latin American Economic Review, October 18, 2021, 1–22. http://dx.doi.org/10.47872/laer.v30.38.

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Policy responses to COVID-19 affected the dynamic of eco¬nomic growth and labor markets worldwide, hitting econom¬ically harder on developing countries. These policies involved economic lockdowns that included the shutdown of the main statistical exercises, making it almost impossible to assess the breadth and variety of their effects. Using a phone survey, this paper examines the impact of the quarantine implemented in Venezuela on labor market outcomes. The identification strategy exploits the exogenous variation in the severity of the lockdown in different regions of the country. The main r

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Hildreth, Kelsey, Haley Overby, Sean Kodani, et al. "Soluble Epoxide Hydrolase Inhibitor t-AUCB Promotes Murine Brown Adipogenesis: Role of PPAR Gamma and PPAR Alpha (P21-069-19)." Current Developments in Nutrition 3, Supplement_1 (2019). http://dx.doi.org/10.1093/cdn/nzz041.p21-069-19.

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Abstract Objectives Brown adipose tissue has recently emerged as a novel target for obesity treatment and prevention. In contrast to the lipid storing function of white adipocytes, brown adipocytes are responsible for dissipating energy as heat, a process involving uncoupling protein 1 (UCP1). Soluble epoxide hydrolase (sEH) is a cytosolic enzyme that converts epoxy fatty acids (EpFAs) into less active diols. By stabilizing endogenous EpFAs, potent small molecule sEH inhibitors have been shown to be beneficial for many chronic diseases. Several recent papers have reported that sEH inhibitors a

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Fan, Baoyan, Wanlong Pan, Xinli Wang, Michael Chopp, Zheng Gang Zhang, and Xian Shuang Liu. "Abstract TMP25: Long Non-Coding RNA Mediates Stroke-Induced Neurogenesis." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.tmp25.

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Background and Purpose: Adult neurogenesis contributes to functional recovery after stroke. Long non-coding RNAs (lncRNAs) regulate stem cell self-renewal and differentiation. However, the role of lncRNAs in stroke-induced neurogenesis remains unknown. Methods and Results: Using lncRNA array and in situ hybridization, we analyzed lncRNA profiles of adult neural stem cells (NSCs) isolated from the subventricular zone neurogenic region in rats subjected to middle cerebral artery occlusion. We found that H19 was the most highly upregulated lncRNA (19 fold) in ischemic NSCs compared with non-ische

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Wang, Jingyu, Lintao Xu, Deqing Peng та ін. "IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury". Inflammation and Regeneration 43, № 1 (2023). http://dx.doi.org/10.1186/s41232-023-00263-9.

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Abstract Background Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed. However, endogenous NSCs in the adult spinal cord differentiate into mostly astrocytes after traumatic injury, forming glial scars, which is a major cause of regeneration failure in SCI. Thus, understanding which factors drive the activation and differentiation of endogenous NSCs after SCI is critical for developing therapeutic drugs. Methods The infiltration, state,

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Rodgers, Krista M., Jared T. Ahrendsen, Frank A. Strnad, et al. "Abstract 70: Neurogenesis in the Pediatric Brain Following Ischemic Stroke: a Potential Target for Endogenous Regeneration and Repair." Stroke 47, suppl_1 (2016). http://dx.doi.org/10.1161/str.47.suppl_1.70.

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Introduction: Following stroke, neurons are seriously damaged or die, impairing local brain function and contributing to long-term disability. Mounting evidence suggests that stroke recovery in children is enhanced compared to adults. Neurogenesis, a process involving the generation of functionally integrated neurons from progenitor cells, may play a role in enhanced plasticity and neuronal repair. Stroke-induced neurogenesis in adults involves massive proliferation and migration of newborn neurons, however these newborn neurons go on to die, never repopulating areas of damage. We tested the h

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Nurhayati, Retno, Yoshihiro Ojima, Naoki Nomura, and Masahito Taya. "Promoted megakaryocytic differentiation of K562 cells through oxidative stress caused by near ultraviolet irradiation." Cellular and Molecular Biology Letters 19, no. 4 (2014). http://dx.doi.org/10.2478/s11658-014-0215-3.

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AbstractReactive oxygen species (ROS) have been proven to be important activators for various cellular activities, including cell differentiation. Several reports showed the necessity of ROS during cell differentiation of the megakaryocytic (MK) lineage. In this study, we employed near ultraviolet (near-UV) irradiation to generate endogenous oxidative stress in an MK differentiation process of K562 cells with phorbol 12-myristate 13-acetate (PMA) induction. A significant increase in the intracellular ROS level was detected on day 1 after near-UV irradiation. In the initial stage of differentia

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Suzuki, Nobuharu, Kaori Sekimoto, Chikako Hayashi, et al. "A Novel Murine Experimental System for Analyzing Differentiation of Oligodendrocyte Precursor Cells Using Sox10‐Venus Mice." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.869.10.

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In the central nervous system (CNS), myelin surrounding axons are formed by oligodendrocytes. Dysfunction of oligodendrocytes in CNS myelination results in neurological disorders, such as leukodystrophy and multiple sclerosis. However, the detailed mechanism of oligodendrocyte differentiation, including cellular process formation, and of myelination has not been elucidated yet, particularly since purification of oligodendrocyte precursor cells (OPCs) from mice, but not rats, is not efficient. We recently created and established a transgenic mouse line that expresses a fluorescent protein Venus

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Preishuber-Pflügl, Julia, Daniela Mayr, Veronika Altinger, et al. "Pericyte-derived cells participate in optic nerve scar formation." Frontiers in Physiology 14 (April 18, 2023). http://dx.doi.org/10.3389/fphys.2023.1151495.

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Introduction: Pericytes (PCs) are specialized cells located abluminal of endothelial cells on capillaries, fulfilling numerous important functions. Their potential involvement in wound healing and scar formation is achieving increasing attention since years. Thus, many studies investigated the participation of PCs following brain and spinal cord (SC) injury, however, lacking in-depth analysis of lesioned optic nerve (ON) tissue. Further, due to the lack of a unique PC marker and uniform definition of PCs, contradicting results are published.Methods: In the present study the inducible PDGFRβ-P2

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Campbell, Ross, Marie-Helena Docherty, David Baird, David Ferenbach, and Katie Mylonas. "#6679 ANALYSIS OF MACROPHAGE POPULATIONS IN THE KIDNEY WITH RENAL TUBULAR CELL-SPECIFIC SENESCENCE INDUCTION." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_6679.

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Abstract Background and Aims Ageing is a risk factor for multiple diseases, including kidney disease. To improve quality of life, pharmaceutical treatments are given to ageing patients, often with side-effects and cross-reactions. Research is needed into the effects and mechanisms of ageing in order to identify new druggable targets to improve quality of life. Cells can become senescent with age and are seen at sites of tissue injury. Senescent cells (SCs) undergo irreversible cell-cycle arrest, but remain metabolically active, producing a range of signalling molecules called the senescence as

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Crews, Fulton T., Rachael Fisher, Chloe Deason, and Ryan P. Vetreno. "Loss of Basal Forebrain Cholinergic Neurons Following Adolescent Binge Ethanol Exposure: Recovery With the Cholinesterase Inhibitor Galantamine." Frontiers in Behavioral Neuroscience 15 (February 26, 2021). http://dx.doi.org/10.3389/fnbeh.2021.652494.

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Binge drinking and alcohol abuse are common during adolescence and cause both cognitive deficits and lasting cholinergic pathology in the adult basal forebrain. Acetylcholine is anti-inflammatory and studies using the preclinical adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2 day on/2 day off from postnatal day [P]25 to P54) model of human adolescent binge drinking report decreased basal forebrain cholinergic neurons (BFCNs) and induction of proinflammatory genes that persist long into adulthood. Recent studies link AIE-induced neuroimmune activation to cholinergic pathology, but the

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Simko, Stephanie, Jacob Johnson, Guillermo Flores, Christopher C. Barney, and Leah Chase. "Exposure to Homocysteic Acid Early in Postnatal Development Leads to a Mixed Depressive/Manic Behavioral Phenotype and Changes in NMDA Receptor Expression." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.1076.3.

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Homocysteic acid (HCA), a NMDA receptor agonist, is an endogenous metabolite formed from the oxidation of homocysteine. Since hyperhomocysteinemia is a risk factor for several neuropsychiatric disorders, including bipolar disorder and major depressive disorder (MDD), we tested the hypothesis that elevated HCA levels in developing rats may induce alterations in NMDA receptor expression and the development of behaviors associated with MDD and/or bipolar disorder. Twenty postnatal male and twenty female rats were injected daily with either HCA or saline from day P3 to P21. HCA‐treated rats displa

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