Relevant bibliographies by topics / Endocytosis / Dissertations / Theses
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Dissertations / Theses on the topic 'Endocytosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Haglund, Kaisa. "Ubiquitination and Receptor Endocytosis." Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4259.

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<p>Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting.</p><p>Termination of signaling by activated receptor tyrosine kinases (RTKs) largely occurs via their endocytosis and subsequent lysosomal degradation, processes accompanied by receptor ubiquitination. Cbl family proteins are major ubiquitin ligases that promote RTK ubiquitination and downregulatio
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2

Webster, Paul. "Endocytosis by African trypanosomes." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280722.

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3

Kalkman, Edward R. I. C. "Endocytosis in filamentous fungi." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/1970.

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Endocytosis is little understood in filamentous fungi. For some time it has been controversial as to whether endocytosis occurs in filamentous fungi. A comparative genomics analysis between Saccharomyces cerevisiae and 10 genomes of filamentous fungal species showed that filamentous fungi possess complex endocytic machineries. The use of the endocytic marker dye FM4-64, and various vesicle trafficking inhibitors revealed many similarities between endocytosis in the filamentous fungus Neurospora crassa, and endocytosis in budding yeast and mammalian cells. Actin polymerization was found to be c
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4

Gagliardi, M. "Endocytosis and wingless signalling." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1353109/.

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Wingless (Drosophila Wnt-1) is secreted glycoprotein that triggers an evolutionary conserved signal transduction pathway. The role of endocytosis in Wnt/Wingless signaling is not clearly understood and highly debated. In my thesis I explore the role that endocytosis/endocytic trafficking has on Wingless signalling activation and termination. In the canonical pathway Wingless binds to a member of the Frizzled family of seven-pass transmembrane receptor (Frizzled1 or Frizzled2) and to Arrow. Formation of this trimeric complex leads to the inactivation of the Armadillo degradation complex and tra
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5

Rehman, Michael. "Analysis of endocytosis at eisosomes." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-135951.

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6

Jha, Ankita. "Quantitative control of GPCR organization and signaling by endocytosis in epithelial morphogenesis." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0393/document.

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Au cours de la gastrulation de l’embryon de Drosophile, l’activation apicale du cytosquelette d’acto-myosine orchestre la constriction apicale dans le mésoderme en invagination ainsi que l’intercalation cellulaire dans l’ectoderme en extension. Un contrôle quantitatif de l’activité des GPCRs et, par conséquent, de l’activation de Rho1 est à l’origine des différences de déformation des cellules du mésoderme et de l’ectoderme mais ces mécanismes demeurent incompris. L’activité du GPCR Smog se concentre respectivement en deux compartiments distincts à la surface de la membrane plasmique (PM) et d
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7

Shurety, Wenda. "Apical endocytosis in Caco-2 cells." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242912.

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8

Karagiannis, Sophia. "The process of endocytosis of CD23." Thesis, King's College London (University of London), 1995. https://kclpure.kcl.ac.uk/portal/en/theses/the-process-of-endocytosis-of-cd23(553202e7-a9c8-444e-b0a5-f7561d1e6297).html.

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9

Nichols, II James Tucker. "DSL-ligand endocytosis and notch signaling." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1692099791&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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10

Wilbur, Jeremy D. "Conformational switches regulate clathrin mediated endocytosis." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324583.

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11

Ohlwein, Nina. "Endocytosis controlled by monolayer area asymmetry." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16403.

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Endozytose erfordert hohe Membrankrümmung und führt zu Flächenänderungen der Membranhälften. Dies kann durch eine Oberflächendifferenz zwischen den Schichten initiiert werden, die durch geänderte Lipidzusammensetzungen hervorgerufen werden kann. Daher wurde die Hypothese aufgestellt, dass Lipid-Transporter zu Beginn der Endozytose für veränderte Flächenverhältnisse verantwortlich sind. Um den Einfluss veränderter Flächen auf Endozytose zu untersuchen, wurden die Oberflächenverhältnisse der Membran durch Zugabe von Phospholipiden verändert und anschließend Endozytose gemessen. Abhängig von der
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12

Ivashenka, Alena. "GL-Lect Endocytosis in In-Vivo Model Systems." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS420.

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Une multitude de voies endocytiques existent à la surface de la membrane plasmique, ce qui conduit à l'endocytose de la majeure partie des membranes ainsi que de leurs protéines associées, des molécules de signalisation, des facteurs de croissance et autres cargos (Smith et al. 2017). Pendant des décennies, la voie majeure dite clathrine dépendante a été la plus étudiée, Cette voie d’endocytose se caractérise par la polymérisation de molécules de clathrine et de protéines adaptatrices au niveau de récepteurs liés à leurs ligands, entrainant la courbure de la membrane, avant sa scission et son
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13

Kowanetz, Katarzyna. "Adaptor Proteins in Regulation of Receptor Endocytosis." Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4477.

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<p>Ligand-induced endocytosis of receptor tyrosine kinases (RTKs) is a dynamic process governed by numerous protein-protein and protein-lipid interactions. This is a major mechanism of signal termination and is also frequently impaired in cancer. The Cbl family of ubiquitin ligases has been shown to play a key role in downregulation of RTKs, by directing their ligand-induced ubiquitination and subsequent lysosomal degradation. My thesis work has led to the identification of novel, ubiquitin-ligase independent, functions of Cbl in receptor endocytosis. We demonstrated that the adaptor protein C
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14

Liu, Guangbo, Alyssa N. Coyne, Fen Pei, et al. "Endocytosis regulates TDP-43 toxicity and turnover." NATURE PUBLISHING GROUP, 2017. http://hdl.handle.net/10150/626460.

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Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 turnover and toxicity depend in part upon the endocytosis pathway. TDP-43 inhibits endocytosis, and co-localizes strongly with endocytic proteins, including in ALS patient tissue. Impairing endocytosis increases TDP-43 toxicity, aggregation, and protein levels, whereas enhancing endocytosis reverses t
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15

Falconer, Helen Louise. "Ca²⁺-dependent interactions in synaptic vesicle endocytosis." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/29095.

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Endocytosis proteins contain a number of different specialised domains which control protein-protein interactions at specific steps. A variety of these domains were used in a proteomic screen using GST-pull down assays from nerve terminal lysates to investigate whether Ca<sup>2+</sup> controlled any specific interactions. Many interactions appeared to occur only in the presence of Ca<sup>2+</sup>, however this was attributed to non-specific binding due to the presence of ZnSO<sub>4</sub>­. Two new interactions were identified that bind SH3 domains only in the absence of Ca<sup>2+</sup>, the ad
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16

Lundmark, Richard. "Sorting nexin 9 in clathrin-mediated endocytosis." Doctoral thesis, Umeå : Department of Medical Biochemistry and Biophysics, Umeå University, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-197.

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17

Ball, S. L. R. "Endocytosis and recycling of angiotensin II receptors." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596314.

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The main finding of this work is evidence that the AT<sub>1</sub>R is constitutively active and can undergo endocytosis and subsequent recycling in the absence of agonist. The application of a putative inverse agonist was able to increase the relative surface density in the presence of an inhibitor of novel protein synthesis. The internal pool partially colocalised with markers for early endosomes and the Golgi Apparatus, and was estimated to be 20% of the surface receptor density. This work has determined the presence of extracellular proteases that cleave the ang II into smaller peptide frag
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18

Holt, M. G. "Exocytosis and endocytosis in a retinal neurone." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604197.

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The synaptic vesicle cycle in the nerve terminal consists of exocytosis and neurotransmitter release, endocytosis and vesicle regeneration. However, the exact mechanisms which underlie this cycle are still largely unknown. This dissertation describes the use of fluorescence microscopy to study aspects of vesicle cycling in the synaptic terminal of retinal depolarizing bipolar cells isolated from goldfish retina. Endocytosis at the synapse may proceed via one of two pathways: through the direct reformation of small vesicles, or through the formation of large cisternae. However, the mechanisms r
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19

Moore, Rachel. "Regulation of JAK/STAT signalling by endocytosis." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22459/.

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The JAK/STAT pathway is a highly evolutionarily conserved signal transduction pathway, whose activation can lead to a broad range of cellular outcomes. The pathway is used repeatedly during multiple developmental stages and in adult tissue, and therefore tight regulation is required to enable accurate responses in a context specific manner. Internalisation and endocytic trafficking of signalling components provides a mechanism whereby spatial compartmentalisation can enable distinct signalling outputs. Within this study I have investigated the role of endocytosis in the regulation of the Droso
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20

Thorley, Jennifer. "Investigating mechanisms of Hepatitis C virus endocytosis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5042/.

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Many viruses exploit and, in some cases, promote host cell endocytic pathways for infection. These pathways include caveolar and clathrin-mediated endocytosis, as well as macropinocytosis. The entry mechanisms of many viruses are not clear cut, with more than one pathway implicated in some cases. Hepatitis C virus (HCV) is a hepatotropic virus associated with liver disease, fibrosis, cirrhosis and hepatocellular carcinoma. There are four co-receptors or “entry factors” for HCV: the tetraspanin CD81, scavenger receptor BI (SR-BI) and the tight junction proteins Claudin 1 (CLDN1) and Occludin (O
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21

Madziva, Michael Taurai. "Mechanisms of M4 muscarinic acetylcholine receptor endocytosis." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619733.

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22

Olesen, Lene Elsnab. "AP2 binding proteins in clathrin-mediated endocytosis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613672.

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23

Marks, Bruno. "Mechanisms and regulation of synaptic vesicle endocytosis." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621839.

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24

Hodson, Nicola Anne. "Identifying novel components of clathrin-mediated endocytosis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648718.

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25

Lu, Mingfeng, and Mingfeng Lu. "Papillomavirus L2-Dependent Endocytosis and Subcellular Trafficking." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621363.

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Human papillomaviruses (HPV) are among the most common sexually transmitted infections and are responsible for 5% of all human cancers. HPV type 16 is the most prevalent of the high-risk HPVs (a subgroup of HPVs with potential to cause cancer), accounting for ~55% of HPV-associated cancers. HPV16 is a nonenveloped virus, composed of the major capsid protein L1, the minor capsid protein L2, and a circular double-stranded DNA genome (vDNA) condensed with human histones. HPV initially infects undifferentiated basal keratinocytes and viral replication is dependent on epithelial differentiation. Li
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26

Kokotos, Alexandros Christoforos. "Molecular identity of activity-dependent bulk endocytosis." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25509.

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At the neuronal synapse, neurotransmitter-filled synaptic vesicles (SVs) fuse with the presynaptic plasma membrane during activity. Following exocytosis, SVs must be retrieved for neurotransmission to be maintained. Several modes of SV recycling have been identified. During mild neuronal activity, clathrin-mediated endocytosis has been regarded as the dominant SV retrieval mode, however the recently identified ultrafast endocytosis mode may also be important in this condition. During elevated activity, activity-dependent bulk endocytosis (ADBE) is the dominant SV retrieval pathway. In ADBE, la
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27

Le, devedec Dahiana. "Role of Confinement on Clathrin-mediated Endocytosis." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS234.

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L’endocytose dépendante de la clathrine (EDC) est la principale voie d’internalisation des récepteurs de surface et de leurs ligands. L’internalisation se fait suite à l’invagination de la membrane plasmique vers l’intérieur de la cellule suite à la formation, dans un premier temps, de puits recouverts de clathrine (PRCs) qui bourgeonnent ensuite en vésicules recouvertes de clathrine dans le cytosol. L’EDC est un processus très dynamique qui a lieu en l’espace de 30 sec-1mn. Elle est impliquée dans de multiples fonctions et permet ainsi à la cellule de réguler l’expression de ses protéines en
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28

Gad, Helge. "Synaptic vesicle endocytosis studied in a living synapse /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4287-0/.

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29

Martinović, Vladan. "Protein complex formation and membrane remodelling in clathrin-mediated endocytosis." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709269.

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30

Hammich, Hussein. "Etude fonctionnelle et structurale de la GTPase Rab35 et de ses effecteurs : vers le mécanisme de contrôle de la dynamique de l'actine dans l'endocytose et la cytocinèse." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2017. https://theses.hal.science/tel-02412888.

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Rab35 est une petite GTPase de la superfamille des Ras protéines. Chez l’Homme, plus de 60 Rabs jouent un rôle clef « d’interrupteur moléculaire » dans la régulation du trafic membranaire. Des progrès significatifs ont été réalisé sur le rôle de certaines Rabs, cependant il reste encore un travail important de compréhension fonctionnelle et du mécanisme d’action de celles-ci au sein de la cellule. L’actuel projet a pour but d’étudier Rab35, un régulateur essentiel d’une voie de recyclage vésiculaire vers la membrane plasmique, aussi impliqué dans la régulation de l’actine lors de la dernière é
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31

Claverie, Léa. "Dynamique d'échange de la dynamine mesurée dans les cellules vivantes pendant la formation de vésicules d'endocytose." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0053.

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L'endocytose dépendante de la clathrine (EDC), c’est-à-dire la formation de vésicules recouvertes de clathrine (VRC) à partir de la membrane plasmique, est un processus essentiel dans les cellules eucaryotes. Au cours de l’EDC, la GTPase dynamine est recrutée au cou de la VRC naissante où elle s'oligomérise en hélice. Les changements de conformation induits par l'hydrolyse du GTP catalysent la scission du cou vésiculaire. Ce processus a été étudié en détail par reconstitution in vitro sur des tubules membranaires, mais il doit être établi dans des cellules vivantes, où les interactions de la d
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32

Bertot, Laëtitia. "Le rôle des protéines courbant les membranes dans l’endocytose indépendante de la clathrine suivie par le récepteur de l’interleukine 2." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS570/document.

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L’endocytose permet l’internalisation d’éléments présents dans le milieu extracellulaire tels que les nutriments. Ce processus prend place dans la membrane plasmique. Les courbures de la membrane jouent un rôle essentiel dans l’endocytose pour générer une invagination initiale, un puits, puis une vésicule qui se sépare ensuite de la membrane plasmique pour fusionner avec les compartiments intracellulaires. Il existe plusieurs voies d’endocytose qui peuvent être classées selon des critères tels que la taille des vésicules produites, la médiation par un récepteur ou la présence d’un manteau reco
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33

Hunjan, Anoop Singh, and Anoop Singh Hunjan. "Chronic Arsenite Exposure in Lung Epithelium Modulates Endocytosis." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626765.

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Arsenic exposure in humans has been implicated in the development of a myriad of non-cancerous and cancerous diseases. A reductionist approach to understanding this unusual phenomenon would suggest that arsenic-induced perturbation of a small number of fundamental biological processes could manifest as this diverse array of disease endpoints. Endocytosis is a fundamental cellular process involved in the internalization and transport of various extracellular molecules and membranous components. BEAS-2B, a human bronchial epithelial cell line, was used to characterize the effects of chronic arse
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34

Evergren, Emma. "Coordination of endocytosis at the synaptic periactive zone /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-683-2/.

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35

Taylor, David Richard. "Mechanisms of endocytosis of the cellular prion protein." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434253.

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36

Hinze, Claudia. "Changes in endocytosis and trafficking during proliferative quiescence." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10060713/.

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A significant proportion of cells in the adult human body, including naïve lymphocytes, hepatocytes, stem cells and cancer stem cells, reside in an actively maintained state of proliferative quiescence (G0). Quiescent cells exit the cell cycle under certain conditions and resume proliferation upon appropriate stimuli, which distinguishes them from senescent or terminally differentiated cells. Little is known about how molecular processes, such as endocytosis, are regulated upon cell cycle exit. The aim of this study was to measure endocytic pathways during quiescence and study how their regul
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37

Glebov, Oleg. "Study of clathrin-independent endocytosis in higher eukaryotes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613725.

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38

Narayanan, Radhakrishnan. "Genetic analysis of endocytosis at the Drosophila synapse." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279946.

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Endocytosis plays an essential role in maintaining a pool of synaptic vesicles for sustained neurotransmitter release. Synaptic vesicles are internalized and fuse with endosomes, and are subsequently reassembled to be ready for another round of exocytosis. Here I describe in two distinct studies the function of endosomes at synapses and regulation of dynamin, a protein essential for endocytosis, using the Drosophila synapse as a model. To study the function of endosomes at synapses I analyzed the localization and function of two Drosophila endosomal proteins, Hook and Deep orange (Dor), at the
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39

St, Pierre Christine A. "Endocytosis, Phagocytosis, and Innate Immune Responses: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/488.

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In this dissertation, the roles of endocytosis and phagocytosis pathways in a variety of clinically relevant scenarios were examined. These scenarios include antibody-mediated internalization of cell surface proteins, titanium wear-particle uptake in failed joint replacements, and polymeric microparticle uptake and immune responses for drug delivery or adjuvant use. The use of antibodies specific for cell surface proteins has become a popular method to deliver therapeutics to target cells. As such, it is imperative to fully understand the ability of antibodies to mediate internalization and en
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40

Yoshida, Hiroyuki. "Compensated endocytosis of LDL by hamster cells co-expressing the two distinct mutant LDL receptors defective in endocytosis and ligand binding." Kyoto University, 1999. http://hdl.handle.net/2433/181746.

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41

Eschenbrenner, Etienne. "Rôles des tétraspanines Tspan5 et Tspan15 dans le contrôle de l'endocytose et du niveau d'expression de la métalloprotéase ADAM10." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS500/document.

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Les tétraspanines sont des protéines à quatre domaines transmembranaires ayant la capacité d’interagir avec des partenaires et de les intégrer au sein d’un réseau dynamique d’interactions nommé tetraspanin web. Parmi elles, les TspanC8 représentent une sous-famille partageant un même partenaire, ADAM10.Cette protéase, essentielle au développement, est responsable du clivage de nombreux substrats dont le récepteur Notch, plusieurs cadhérines et facteurs de croissance. ADAM10 est également impliquée dans la régulation de plusieurs pathologies, telles que la maladie d’Alzheimer ou des cancers.Les
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42

Stunt, Richard John. "The role of the cytoplasmic domain in the localisation of CTLA-4 and CD28." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274324.

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43

Roosen, Gert. "Design and development of a synthetic shuttle vector for DNA delivery." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365910.

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44

Karakikes, Ioannis. "Association of the invariant chain (CD74) and human leucocyte antigen (HLA) DR : a single molecule approach." Thesis, University of Essex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274374.

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45

Paolucci, Clara. "Role of nitric oxide in the maturation process of human dendric cells." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273309.

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46

Taylor, Marcus. "The molecular dynamics of clathrin mediated endocytosis in live cells." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609138.

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47

Kozik, Patrycja. "Sorting signals and machinery in the endocytic pathway." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609631.

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48

Vonderheit, Andreas. "Visualization of the endocytosis pathway of Semliki forest virus /." [S.l.] : [s.n.], 2004. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15853.

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49

Kirkham, Matthew John. "The role of caveolin in endocytosis and caveolae biogenesis /." [St. Lucia, Qld.], 2006. http://adt.library.uq.edu.au/public/adt-QU20060713.115922/index.html.

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50

Samuels, Anne Lacey. "Endocytosis in elongating root tip cells of Lobelia erinus." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29279.

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Endocytosis was measured along the axis of differentiation of epidermal and cortical root cells of Lobelia erinus from meristematic to fully expanded vacuolate cells. Both lanthanum and lead were tested as markers of endocytosis; lanthanum proved to be more effective. Lanthanum treatment produced electron dense deposits in the apoplast of the root, as well as coated pits, coated vesicles, smooth vesicles and multivesicular bodies within the cells. X-ray microanalysis was used to confirm the lanthanide nature of the deposits. In both secretory (meristematic and elongating cells actively deposi
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