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Dissertations / Theses on the topic 'Endocrinology; Type-2 diabetes mellitus'

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Published: 4 June 2021

Last updated: 15 February 2022

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1

Tukay, Remeliza Navarrete. "Diabetes Mellitus Type 2: A Quality Improvement and Patient Safety Initiative." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/3213.

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The purpose of the quality improvement (QI) project was to examine the relationship between amended nursing education concerning diabetes mellitus (DM) Type 2 self-care management incorporating Tune in, Explore, Assist, Communicate, and Honor (TEACH) and Motivational Interviewing (MI) strategies and techniques and the Glycosylated hemoglobin (HgbA1C) of veteran patients with uncontrolled diabetes. The target sample included the 2 licensed practical nurses and 2 registered nurses assigned to 2 primary care teams, and the 10 purposively sampled patients with uncontrolled DM Type 2 from each team

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2

Bengtsson, Lisa, and Zhiar Mohamed. "Egenvård vid diabetes mellitus typ 2 - En litteraturöversikt." Thesis, Jönköping University, Hälsohögskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52910.

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3

MacArthur, Diane L. A. "Amyloid fibril formation in islets of transgenic mice expressing human islet amyloid polypeptide." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325942.

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4

Löwendahl, Alma, Emelie Karlsson, and Therese Svensson. "Att leva med diabetes mellitus typ 2 : En kvalitativ litteraturöversikt." Thesis, Jönköping University, HHJ, Avd. för omvårdnad, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52580.

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Titel: Att leva med diabetes mellitus typ 2. Bakgrund: Diabetes mellitus typ 2 (DMT2) är ett globalt problem och fler personer insjuknar årligen. Egenvård är en central del av behandlingen för dessa personer. Att förstå livsstilsförändringar, behandlingar och egenvården hos dessa personer bidrar till ökad kunskap inom hälso- och sjukvården. Syfte: Att beskriva personers erfarenheter av att leva med diabetes mellitus typ 2. Metod: Litteraturöversikt med artiklar av kvalitativ design baserad på 12 vetenskapliga artiklar från databaserna Cinahl och MedLine. Resultat: Resultatet presenteras

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5

Al-Ghamdi, Yasser. "The Effects of Probiotics on High Sugar-Induced Type 2 Diabetes Mellitus Symptoms in Drosophila melanogaster." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17817.

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Background: Type 2 diabetes mellitus is a metabolic disorder characterized by the rise of fasting plasma glucose from its normal range (≥125mg/dl). It is marked by insufficient production of insulin from pancreatic β-cells as a result of failed compensation due to insulin resistance. Several treatments are available for the disorder, which mainly focus on improving the sensitivity of insulin in different body tissues. Recently, probiotics were suggested as candidate treatments for type 2 diabetes and for extending lifespan as well. This experiment aims to investigate such claims using Drosophi

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6

Pye, Theresa. "Impact of Group Medical Visits for Adult Patients with Type 2 Diabetes Mellitus." UNF Digital Commons, 2011. http://digitalcommons.unf.edu/etd/378.

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Diabetes is a condition that is primarily self-managed and lifestyle modifications such as diet, exercise, and weight management are necessary to reduce morbidity and mortality. Motivation to implement lifestyle modifications through self management is an integral part of disease management and studies have shown group medical visits are more effective than individual appointments in this patient population. The purpose of this project was to develop, implement and evaluate an evidencebased group medical visit program for up to a maximum of 8 adult patients with type 2 diabetes in a family pra

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7

Ghadzi, Siti Maisharah Sheikh. "Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317040.

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Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM. The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. The appropriate

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8

Ramsumeer, Soy. "A Plan for the Implementation and Evaluation of Diet Education in Type 2 Diabetes." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/1920.

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Abstract Type 2 Diabetes Mellitus (T2DM) is the seventh leading cause of death in the United States with a projected increase of 552 million people worldwide who will be affected with this illness by 2030. The need to address this issue is vital to prevent complications and reduce healthcare spending. The DNP project is aimed at planning and designing a nutritional education program tailored toward specific ethnic groups in order to increase knowledge in making healthy food choices. This project is intended to educate Registered Nurses (RNs) on nutrition so that they can offer dietary knowledg

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9

Dannison, Phawlay, and Mustafa Rezaei. "Personers upplevelser av att leva med typ 2 diabetes." Thesis, Högskolan i Gävle, Avdelningen för vårdvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-31317.

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Sammanfattning Bakgrund: Diabetes mellitus typ 2 (DMT2)är en av den vanligaste sjukdomarna och den ökar mer och mer på grund av ohälsosam livsstil. Faktorer som höjer risken för att utveckla DMT2 är livstillfaktorer som till exempel tobak, minskad fysisk aktivitet, stillasittande liv, matvanor och fetma. Sjukdomen behandlas med hälsosam kost, fysisk aktivitet och medicinering. Syftet: Syftet med studie var att beskriva personers upplevelser av att leva med DTM2. Metod: Litteraturstudie med en beskrivande design som bygger på 13 kvalitativa artiklar. Resultat: personerna upplever en psykologisk

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10

Gustafsson, Julia, and Maria Vallberg. "Sjuksköterskors erfarenheter av egenvård hos diabetes typ-2 patienter." Thesis, Högskolan i Gävle, Avdelningen för vårdvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-35697.

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Bakgrund: Diabetes mellitus typ-2 är en av de vanligaste folksjukdomar världen över, i Sverige uppskattas det till att ca 300 000 människor lider av sjukdomen. En stor del av behandlingen för människor med diabetes typ-2 är att ändra sina matvanor, fysisk aktivitet och att medicinera sig själva, detta kallas för egenvård. En stor del av sjuksköterskors arbete med diabetes typ-2 patienter är att motivera och ge stöd till patienterna så att de efterlever de livsstilsråd som ges i den mån det går. Hur patienterna upplever sin egenvård ser olika ut, några menade att eftersom sjukdomen är genetisk

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11

Miyamoto, Janine Hatsumi. "Prevalência de Síndrome Metabólica em Diabetes Mellitus tipo 2 e associação com Doença Coronariana." Faculdade de Medicina de São José do Rio Preto, 2012. http://bdtd.famerp.br/handle/tede/109.

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Made available in DSpace on 2016-01-26T12:51:31Z (GMT). No. of bitstreams: 1 janinehatsumimiyamoto_dissert.pdf: 287223 bytes, checksum: 94be79897234bdddd89d8d839f550e34 (MD5) Previous issue date: 2012-01-25<br>Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from insulin secretion defects, in its peripheral action, or both. Clinical manifestations of diabetes are broad and can range from asymptomatic glucose intolerance to acute complications as diabetic ketoacidosis or complications of slow evolution, such as neurological and vascular changes. Vasc

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Kwet, Avril. "Socker men inte söt: upplevelser av diabetes typ 2 : en kvalitativ litteraturstudie." Thesis, Linnéuniversitetet, Institutionen för hälso- och vårdvetenskap (HV), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-89790.

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Background: Diabetes type 2 is a chronic system disease which has a huge impact on the patient’s life. The disease can lead to many sequalae and involves different types of sufferings for the patient. The treatment consists of both medical and lifestyle changes where self-care has great importance. Previous researches have made evident that life with diabetes type 2 means a great change in lifestyle that affects the patient psychologically, physically, spiritually and socially. In addition, there were many people who had difficulty making these changes. Patients experienced shame because diabe

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13

Österberg, John, and Namir Rahim. "En beskrivning av hur personer med diabetes typ 2 upplever att genomgå livsstilsförändringar till följd av sjukdomen." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-26478.

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Bakgrund: Diabetes är en av de sjukdomar som är mest växande globalt. I Sverige är det över 400 000 människor som lever med diabetes. Diabetessjukdomen finns i olika former och de vanligaste formerna är diabetes typ 1 och diabetes typ 2. Risken att bli drabbad av den sjukdomen ökar vid fetma, tobaks- och alkoholkonsumtion. Därför kan det bli nödvändigt att genomföra livsstilsförändring för att förbättra den mentala och fysiska hälsan hos personer som lever med diabetes typ 2. Syfte: Syftet med denna studie var att beskriva hur personer med diabetes typ 2 upplever att genomgå livsstilsförändr

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14

Elangovan, Saravanan, Jacek Smurzynski, Emily Crewe, and Erin Dula. "Investigation of Auditory Processing Deficits in Patients With Type II Diabetes Mellitus (DM)." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/1569.

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The incidence of DM is 9.6% in the USA with its prevalence increasing globally (NIDDKD, 2005). A common, but under-recognized complication of DM is hearing difficulty (~ 93%). However, the nature of this often sub-clinical dysfunction is still poorly understood. The aim of this study is to better understand DM-related hearing loss.

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15

Larson, Kara L. "Regulation of Glucose Homeostasis by the PHLPP1 Phosphatase." UKnowledge, 2014. http://uknowledge.uky.edu/biochem_etds/17.

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Type 2 diabetes mellitus is a metabolic disease that affects one in ten people in the United States. It is caused by a combination of genetics and lifestyle factors. Disease progression begins with insulin resistance in peripheral tissues followed by pancreatic beta-cell failure. The mechanisms behind disease progression are not completely understood. PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) is a known regulator of Akt and other members of the AGC kinase family. Akt has been established to play a role in numerous metabolic signaling pathways, including insulin action. It is

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Hult, Amanda, Hanna Malmlöf, and Sonia Magnusson. "Erfarenheter av egenvård hos unga vuxna med diabetes mellitus typ 1 : En kvalitativ litteraturöversikt." Thesis, Jönköping University, HHJ, Avd. för omvårdnad, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-51647.

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Bakgrund: I Sverige är det cirka 50 000 personer som lever med diabetes mellitus typ 1. Det är en kronisk komplex sjukdom som kräver livslång behandling. Sampel med vården krävs under hela sjukdomsförloppet där en god vårdrelation blir betydande. Självkännedom och god självkänsla underlättar för egenvården eftersom det handlar om att kunna se de egna styrkorna för en god hanteringsförmåga av sjukdomen. Syfte: Syftet var att beskriva erfarenheter av egenvård hos unga vuxna med diabetes mellitus typ 1. Metod: En kvalitativ litteraturöversikt med induktiv ansats har gjorts. Resultatet baseras p

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Evanson, Thea. "Preventiv behandling mot Diabetes Mellitus typ I : En jämförande litteraturstudie mellan Coxsackievirus-B-vaccin och behandling med GAD-alum." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-103118.

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Bakgrund: Diabetes Mellitus typ I är ett globalt hälsoproblem som skördar många liv varje år och påverkar livskvaliteten för de drabbade. Diabetes typ I är en autoimmun sjukdom som leder till destruktion av insulinproducerande betaceller i pankreas och således rubbad glukosreglering. Huvudsakliga patogena immunceller inkluderar autoantikroppar, exempelvis riktade mot glutaminsyra dekarboxylase 65, och autoreaktiva T-celler. Diagnos sker generellt baserat på förhöjda halter plasmaglukos och eventuellt stimulering av C-peptid för att utreda status för den endogena betacellsfunktionen. Diabetesko

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18

Bjarnegård, Niclas. "Aspects on wall properties of the brachial artery in man : with special reference to SLE and insulin-dependent diabetes mellitus." Doctoral thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11273.

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The mechanical properties of the arterial wall are of great importance for blood pressure regulation and cardiac load. With increasing age, large arteries are affected by increased wall stiffness. Furthermore, atherosclerotic manifestations may increase the stiffness even further, both processes acting as independent cardiovascular risk factors affecting the arterial system in a heterogeneous way. The aims of this thesis was to characterize the local mechanical properties of brachial artery (BA) with the aid of ultrasound technique and to evaluate the influence of 1) age, gender, sympathetic s

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19

Gellar, Lauren A. "The Effect of Glycemic Index and Glycemic Load on Glucose Control, Lipid Profiles and Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/522.

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Background The incidence of type 2 diabetes has increased dramatically, particularly among Latinos. While several studies suggest the beneficial effect of lowering glycemic index and glycemic load in patients with type 2 diabetes, no data exists regarding this issue in the Latino population. The purpose of this study was to determine the effect of lowering glycemic index and glycemic load on diabetes control, lipid profiles and anthropometrics among Latinos with type 2 diabetes. Methods Subjects participated in a 12 month randomized clinical trial. The intervention targeted diabetes knowledge,

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20

Fernandes, Ana Barbosa de Matos Abreu. "Regulação integrada do metabolismo da glucose no estado pós-prandial : fisiologia e reversão de processos patológicos." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2011. http://hdl.handle.net/10362/7719.

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Resumo: Os mecanismos que regulam a homeostase da glucose no pós-prandial são distintos dos mecanismos desencadeados em situações de jejum. Desta forma o fígado parece desempenhar um papel fundamental na acção periférica da insulina após a refeição através de um mecanismo que envolve os nervos parassimpáticos hepáticos e o óxido nítrico (NO). Esta dissertação procura evidenciar a importância de ambos na fi siologia de manutenção da glicémia pós-prandial e na fi siopatologia da resistência à insulina. Dos resultados obtidos observou-se que após a administração de uma refeição mista o pe

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Maguire, Laura L. "Educating Grandparents of Grandchildren with Type I Diabetes Using Simulation: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsn_diss/38.

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The purpose of this study was to explore the feasibility of using human patient simulation (HPS) to teach Type 1 diabetes (T1DM) management to grandparents of grandchildren with T1DM. Thirty grandparents (11 male, 19 female) of young grandchildren (aged 12 and under) with T1DM were recruited from an urban medical center. Experimental group (n = 14) grandparents received hands-on visual T1DM management education using an HPS intervention, and control group (n = 16) grandparents received similar education using a non-HPS intervention. Post-intervention, researchers interviewed twelve grandparent

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Wolffenbuttel, Bruce Herbert Ralph. "Type 2 diabetes mellitus pathology and treatment /." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=5673.

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23

Andrews, Robert. "Cortisol metabolism in type 2 diabetes mellitus." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/23073.

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In chapter 2, I describe my first study, which determined whether individuals with DMA or impaired glucose tolerance (IGT) exhibit abnormalities in cortisol activity. An integrated assessment of cortisol secretion, metabolism and action was carried out in 25 un-medicated lean male patients with hyperglycaemia (20 DM and 5 IGT) and 25 healthy controls carefully matched for body mass index, age and blood pressure. This study demonstrated that patients do exhibit abnormalities in cortisol activity. Chapter 3 describes a study that examined whether altered tissue concentration of the glucocorticoi

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Li, Luosheng. "Molecular genetics of type 2 diabetes /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-194-2/.

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Zhou, Huali. "Reverse cholesterol transport in type 2 diabetes mellitus." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39794003.

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Zhou, Huali, and 周華麗. "Reverse cholesterol transport in type 2 diabetes mellitus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39794003.

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27

Saugur, Anusooya. "Management of type 2 diabetes mellitus : a pharmacoepidemiological review." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1635.

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Type 2 diabetes mellitus (DM) is a progressive disease characterised by hyperglycaemia caused by defects in insulin secretion and insulin action. In early stages of type 2 DM, dietary and lifestyle changes are often sufficient to control blood glucose levels. However, over time, many patients experience β cell dysfunction and require insulin therapy, either alone or in combination with oral agents. There are guidelines available to structure the management of this disease state, including both the use of oral hypoglycaemic agents and or insulin. Besides health complications, there are economic

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Praet, Stephan Florent Eugenie. "Exercise therapy in Type 2 diabetes." Maarsen : Maastricht : Elsevier gezondheidszorg ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9387.

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Dennis-Bradshaw, Rondalyn. "Diabetes Self-Management Education for Adults With Type 2 Diabetes Mellitus." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1812.

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Diabetes, a major public health challenge in St. Kitts, has been a focus of international public health community research. Although researchers have demonstrated that diabetes self-management education is a cost-effective strategy for the prevention of diabetes-related complications, they have yet to establish whether there is adequate education occurring in treatment settings with diabetic patients. The purpose of the study was to implement and evaluate the short-term effectiveness of a diabetes self-management education intervention on diabetes-related knowledge and accepted behavioral chan

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Espelt, Hernández Albert 1981. "Socioeconomic inequalities in type 2 diabetes mellitus in Europe." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/85055.

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Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide. The St. Vincent declaration emphasized the urgent need to improve the epidemiological knowledge of this disease in Europe. Within Europe, research on the link between socioeconomic position (SEP) and type 2 diabetes is scarce. The objective of this thesis was to conduct an extensive review of the current literature on socioeconomic inequalities in type 2 diabetes within European countries, while analyzing the relationship between, incidence, prevalence and mortality due to T2DM and SEP. In addition, we also analyzed

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Isaacs, Renee Lalitha Cordelia. "Diet and type 2 diabetes mellitus in the Caribbean." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0004/MQ45413.pdf.

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32

Jeragh, Alhaddad Fatima Bakir. "Nonadherence among Kuwaiti nationals with type 2 diabetes mellitus." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522824.

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Rees, S. M. "Bone density and neuropathy in type 2 diabetes mellitus." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419549.

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Johnson, Andrew. "Skeletal muscle insulin action in type 2 diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321306.

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35

Minnaar, Danielle. "Audiovestibular function in adults with type 2 Diabetes Mellitus." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/65584.

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Diabetes is one of the most prominent health emergencies of the 21st century affecting millions worldwide. Approximately 415 million individuals had diabetes in 2015, more than 10% living in the Sub-Saharan Africa region. Diabetes is a chronic illness and is classified according to aetiology. Type 2 diabetes accounts for more than 90% of cases. The disease is initially asymptomatic resulting in 30% to 85% of cases remaining undiagnosed. Due to the delayed diagnosis, approximately 20% of the individuals will have developed secondary complications. Disorders of the auditory and vestibular system

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Noll, Amanda N., and L. Lee Glenn. "Self-Efficacy and Management in Type 2 Diabetes Mellitus." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/7493.

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Doyle, Todd A. "Inflammatory Pathways Linking Type 2 Diabetes Mellitus and Depression." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1332460860.

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38

McDowell, Joan Rachel Somerville. "Management of Type 2 diabetes mellitus in primary care." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5139/.

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Background: The incidence and prevalence of diabetes mellitus (diabetes) is increasing globally. The majority of people have type 2 diabetes, initially managed by lifestyle changes and the gradual introduction of oral, followed by subcutaneous, medications. Due to the increasing numbers of people with type 2 diabetes, different models of care management have been utilised within the United Kingdom. One Health Board within Scotland received funding to undertake a service redesign whereby the responsibility of care for people with type 2 diabetes was transferred from secondary care to primary ca

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Quandt, Raegan Elizabeth. "Education Protocol for Type II Diabetes Mellitus." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/6095.

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Diabetes mellitus is one of the leading causes of death in the United States, contributing to rising health care costs and increased morbidity and mortality rates. Researchers demonstrated that aggressive heath measures involving ongoing diabetes self-management education are paramount in minimizing associated complications of diabetes. The management and prevention of diabetes is not standardized and providers within a health clinic in Illinois reported challenges in providing self-management education during scheduled patient appointments due to limited resources and time. The purpose of thi

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Eltahla, Auda Abdelsalam Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Gestational diabetes mellitus: a model for the genetics of type 2 diabetes." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44607.

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The striking similarity between Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) in terms of the pathophysiologies and the risk factors has led to the hypothesis that GDM is an early manifestation of T2D, expressed under the stress of pregnancy, and therefore both diseases should share similar susceptibility genes. GDM patients may provide a more homogeneous sample for the genetic causes of the disease than T2D, and therefore make a useful group for the identification of the genes involved. Over 200 GDM affected sib-pairs from 178 families were investigated, with parents available

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Sudagani, Jaidev. "Genes and type 2 diabetes : polymorphisms of the EIF2AK3 gene and its relationship to type 2 diabetes mellitus." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/411.

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Aims/ Hypothesis: Wolcott- Rallison syndrome (WRS) is a rare autosomal recessively inherited Mendelian disorder. It is characterised by a short trunk compared to arm span, multiple epiphyseal dysplasia, multiple fractures, hepatosplenomegaly and renal insufficiency in addition to insulin dependent diabetes. The onset of diabetes in WRS families is mainly below the age of 6 months and is characterised by permanent severe non-autoimmune insulin deficiency. Mutations of the gene encoding eukaryotic translational initiation factor 2 - alpha kinase 3 (EIF2AK3) were found to account for diabetes in

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Mathur, Aditi. "Genetic association between schizophrenia and type-2 diabetes." Thesis, University of the Highlands and Islands, 2011. https://pure.uhi.ac.uk/portal/en/studentthesis/genetic-association-between-schizophrenia-and-type2-diabetes(71a1d702-37b0-470d-87d9-956cbd52c821).html.

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Aims: This PhD project was designed under two studies, the genetic association study to investigate a genetic component or a genetic pathway that might be associated with both schizophrenia and type-2 diabetes (T2D). The gene functional study to explore whether clozapine could affect expression of the genes associated with obesity and T2D. Methods: In genetic association study, a total of 17 single nucleotide polymorphisms (SNPs) were genotyped in the PPARG, PLA2G4A, PTGS2 and AKT1 genes in 221 British nuclear families. In the gene functional study, U937 cells were treated with clozapine (1g/

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Travers, Mary E. "Mechanisms of Type 2 diabetes susceptibility." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d99892d8-534a-4908-b5dc-ab1d8b1cab52.

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Type 2 diabetes (T2D) has a genetic component which is only partially understood. The majority of genetic variance in disease susceptibility is unaccounted for, whilst the precise transcripts and molecular mechanisms through which most risk variants exert their effect is unclear. A complete understanding of T2D susceptibility mechanisms could have benefits in risk prediction, and in drug discovery through the identification of novel therapeutic targets. Work presented in this thesis aims to define relevant transcripts and disease mechanisms at known susceptibility loci, and to identify disease

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Mbaya, John Kabamba. "Lay beliefs of type 2 diabetic patients at Prince Mshiyeni Memorial Hospital, Durban." Thesis, University of Limpopo (Medunsa Campus), 2010. http://hdl.handle.net/10386/547.

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Thesis (M Med(Family Medicine))--University of Limpopo (Medunsa Campus) 2010.<br>Aim & Objectives Aim: To explore the lay beliefs of type 2 diabetic patients seen at Prince Mshiyeni Memorial Hospital. Objectives: To understand lay beliefs of effective life long management of type 2 diabetes patients and consequently to make recommendations of improving management of diabetes in conjunction with the findings of the study. Methodology Study Design: An exploratory study from a qualitative perspective using free attitude interviews as a data collection technique. Setting: Prince Mshiyeni Memo

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Hamilton, Dorothy Jean. "The Lived Experience of Homeless Individuals with Type 2 Diabetes Mellitus." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent160623154767295.

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Yates, Thomas E. "Can we out-walk the type 2 diabetes mellitus epidemic?" Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/8077.

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Type 2 diabetes mellitus is a chronic and debilitating disease whose prevalence continues to rise inexorably. Type 2 diabetes is usually preceded by a condition called prediabetes, which is characterised by impaired glucose regulation. Those with prediabetes have a significantly increased risk of developing type 2 diabetes compared to those with normal glucose control and therefore represent a key population in the prevention of type 2 diabetes. Physical inactivity is thought to be one of the key factors driving the increasing prevalence of prediabetes and type 2 diabetes and consequently form

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Hoffman, Kristin. "Cancer treatment and cellular stress induced type 2 diabetes mellitus." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12422.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Some cancer treatments induce stress responses that activate protective mechanisms and neuregulin expression. In turn, neuregulin activates ErbB receptors, which are responsible for phosphorylating Insulin Recep

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Mutize, Tinashe. "DNA methylation : a risk factor for type 2 diabetes mellitus." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2388.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2016.<br>The early detection of individuals who are at risk of developing type 2 diabetes mellitus (T2DM) would decrease the morbidity and mortality associated with this disease. DNA methylation, the most widely studied epigenetic mechanism, offers unique opportunities in this regard. Aberrant DNA methylation is associated with disease pathogenesis and is observed during the asymptomatic stage of disease. DNA methylation has therefore attracted increasing attention as a potential biomarker for identifying individual

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Perez, Nieves Magaly. "The Association between Rheumatoid Arthritis and Type 2 Diabetes Mellitus." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1228.

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A research report from the Centers for Disease Control and Prevention (CDC) indicated that more than 50% of people with diabetes mellitus (DM) in the United States (U.S.) also have arthritis. The diabetes population is disproportionately affected by arthritis, but there has been limited and inconsistent research to confirm the association between type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA). The current study aimed to identify an association between T2DM and RA for noninstitutionalized U.S. adults between 1999 and 2012 using a nationally representative sample from the National

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McCann, Adrian. "Physical activity in the management of type 2 diabetes mellitus." Thesis, Cardiff Metropolitan University, 2011. http://hdl.handle.net/10369/3471.

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The incidence of type 2 diabetes mellitus (T2DM) is rising throughout the world. Explicit evidence has demonstrated sedentary behaviour is a powerful but modifiable risk factor affecting glycaemic control and the incidence of diabetes complications. Despite this, current population estimates indicate the importance of physical activity is not effectively translated to the T2DM population. The aim of this thesis was therefore to investigate barriers and facilitators to physical activity behaviour among individuals with T2DM. An extensive literature review investigating evidence linking physical

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