Dissertations / Theses on the topic 'Endocrine aspects'
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Ritchie, Catherine Marian. "Aspects of hypertension in endocrine disease." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357488.
Full textDelgado, Verdugo Alberto. "Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224111.
Full textMerani, Salima A. "Development of a specific and sensitive assay for cholecystokinin, and applications thereof." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37619.
Full textAfter developing the cholecystokinin assay system, we were able to combine our unique methodology with other established techniques to investigate the role of CCK in illnesses such as premenstrual dysphoric disorder (PMDD), anxiety, bulimia nervosa, and cardiomyopathy.
Briefly, we observed no significant differences in plasma CCK levels between women with PMDD and healthy volunteers. However, we found that, independent of diagnosis, plasma cholecystokinin concentrations were higher in women during their first visit to the clinic to participate in the study, as compared to later visits.
In addition, application of our assay system allowed us to determine that oral ingestion of caffeine increased plasma CCK-LI levels 2--4 fold in humans. Moreover, we observed substantial variation in post-caffeine cholecystokinin levels among individuals.
In another study of cholecystokinin and anxiety, we used our CCK assay to determine the effects of ondansetron, a serotonin receptor antagonist, on cholecystokinin levels in plasma. We found that multiple oral doses of ondansetron influence the pharmacokinetic parameters of exogenous CCK.
We also used the three-step assay system to measure CCK-LI in patients with the eating disorder, bulimia nervosa. Baseline fasted cholecystokinin plasma levels were lower in bulimic women as compared to control subjects. However, at "satiety", or the post-binge stage, CCK levels in bulimic women were similar to those of control women.
Finally, our investigation into the role of cholecystokinin in cardiomyopathy revealed that neuronal cholecystokinin receptor density was altered in the cardiomyopathic hamster brain, as compared to age- and sex-matched control animals. (Abstract shortened by UMI.)
Heaney, Anthony Patrick. "Aspects of pituitary and adrenal disease." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295358.
Full textHenderson, Keith Meade. "Aspects of the endocrine control of ovarian function." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/14052.
Full textMeloni, T. "SOME PERINATAL ENDOCRINE AND MORPHOLOGICAL ASPECTS OF CANINE SPECIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265723.
Full textBehera, Malabika. "Long term endocrine sequelae of childhood cancer survivors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206611.
Full textpublished_or_final_version
Paediatrics and Adolescent Medicine
Master
Master of Medical Sciences
Fjällskog, Marie-Louise. "Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2709.
Full textWe treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs.
Thirty-six patients with neuroendocrine tumors were treated with cisplatin combined with etoposide. Of 14 patients with evaluable EPTs, 50% responded radiologically and/or biochemically (median duration 9 months). We consider this treatment useful as first-line medical treatment in aggressive EPTs or in patients failing prior chemotherapy.
Twenty-eight tumor tissues from EPTs were examined with immunohistochemistry regarding expression of somatostatin receptors (ssts) 1 to 5 on tumor cells and in intratumoral vessels. We found that sst2 and sst4 were highly expressed on tumor cells and in vessels. However, sst3 and sst5 were lacking in half of the tumor tissues and in most of the vessels. Because of the variability in sst expression, we recommend analysis of each individual’s receptor expression before starting treatment.
Endocrine pancreatic tumors (EPTs) are rare with an incidence of 4 per million inhabitants. In the majority of cases they grow slowly, but there are exceptions with very rapidly progressing malignant carcinomas. First-line medical treatment is streptozotocin combined with 5-fluorouracil.
We examined 38 tumor samples regarding expression of tyrosine kinase receptors platelet-derived growth factor receptors (PDGFRs), c-kit and epidermal growth factor receptor (EGFR). We found that the receptors were expressed in more than half of the tumor tissues. Further studies will reveal if tyrosin kinase antagonists can be part of the future treatment arsenal.
Chu, Xia. "Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands." Doctoral thesis, Uppsala universitet, Endokrin Onkologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254817.
Full text譚銓株 and Chuen-chu Tam. "Hormonal effects of the lateral prostate and seminal vesicle of the guinea pig: an ultrastructural, morphometricand cytochemical study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B3123169X.
Full textPryor, Andrew William. "Reproduction and Endocrine Aspects of Early and Mid Lactation Holstein Cows." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/32486.
Full textMaster of Science
Rodrigues, Mark. "Hormonal and non-hormonal factors associated with cognition in post-menopausal women." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0075.
Full textRautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.
Full textFridström, Margareta. "Endocrine and therapeutic aspects of infertile women with the polycystic ovary syndrome /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3175-5/.
Full textTeske, Sondra Sue Gery. "Aspects of Measuring Mass Balances of Endocrine Disrupting Compounds through Wastewater Treatment." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194944.
Full textYip, Ka-yiu, and 葉嘉嬈. "Investigation of growth and endocrine disrupting effects of the mycotoxins zearalenone and aflatoxin B1 on breast cancer in vitro." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209490.
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Biological Sciences
Doctoral
Doctor of Philosophy
Ernestam, Sofia. "Rheumatoid arthritis : pharmacological modulation of cytokines - aspects of clinical response and endocrine regulation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-628-X/.
Full textSilva, Juliana Polloni. "Aspects of endocrine disruptors remediation using in vitro and in vivo ecotoxicological assays /." Sorocaba, 2017. http://hdl.handle.net/11449/150558.
Full textResumo: Chemicals with potential to cause endocrine disruption in vertebrates and invertebrates have been detected at low concentrations in the world's aquatic environments. Therefore, the search for removal methodologies in aquatic environments became a worldwide interest. The aim of this research was to investigate three materials (powered activated carbon - PAC, powered natural zeolites - ZP and aquatic humic substances - AHS) in chemical and ecotoxicological remediation of 17ß-estradiol (E2) and 17α-ethinylestradiol (EE2) in water through chemical and biological tests in vitro and in vivo. An environmentally relevant concentration of hormones (30 ng.L-1) was used during laboratory tests. The results obtained through an extensive list of morphological, reproductive and histological parameters showed the significant impact of HSFs on the development and maintenance of exposed fish. The superior efficiency of PAC was verified in relation to the other substrates in the endocrine disrupting chemicals (EDCs) removal in water. Nevertheless, their properties did not guarantee the same performance to the environmental samples, neither allow biological injuries monitored to be recovered after the period of depuration investigated. An additional study also allowed the development of a histochemical protocol capable of identifying the production of vitellogenin (VTG) prompted by exposure to the synthetic steroid EE2.
Doutor
Silva, Juliana Polloni [UNESP]. "Aspects of endocrine disruptors remediation using in vitro and in vivo ecotoxicological assays." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150558.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Produtos químicos capazes de causar desregulação endócrina em vertebrados e invertebrados têm sido detectados a baixas concentrações em ambientes aquáticos do mundo. Desta maneira, tornou-se de interesse mundial a busca por metodologias de remoção mesmos nos ambientes aquáticos. Por isso pesquisa teve como objetivo investigar três materiais (carvão ativado em pós – PAC, zeólitas naturais em pó – ZP e substâncias húmicas aquáticas – AHS) na remediação química e ecotoxicológica de 17ß-estradiol (E2) e 17α-etinilestradiol (EE2) em água mediante ensaios químicos e biológicos in vitro e in vivo. Uma concentração ambientalmente relevante de hormônios (30 ng.L-1) foi utilizada durante os ensaios em laboratório. Os resultados obtidos por meio de uma extensa relação de parâmetros morfológicos, reprodutivos e histológicos adotados permitiram concluir o significativo impacto dos HSFs sobre o desenvolvimento e manutenção de peixes expostos. Comprovou-se a superior eficiência do PAC em relação aos demais substratos na remoção de interferentes endócrinos (IEs) em água. Não obstante, suas propriedades não garantiram o mesmo desempenho com relação a amostras ambientais e, tampouco possibilitou a recuperação das injurias biológicas monitoradas após período de depuração investigado. Um estudo adicional também permitiu a elaboração de um protocolo histoquímico capaz de identificar a produção de vitelogenina (VTG) incitada pela exposição ao esteróide sintético EE2.
Chemicals with potential to cause endocrine disruption in vertebrates and invertebrates have been detected at low concentrations in the world's aquatic environments. Therefore, the search for removal methodologies in aquatic environments became a worldwide interest. The aim of this research was to investigate three materials (powered activated carbon - PAC, powered natural zeolites - ZP and aquatic humic substances - AHS) in chemical and ecotoxicological remediation of 17ß-estradiol (E2) and 17α-ethinylestradiol (EE2) in water through chemical and biological tests in vitro and in vivo. An environmentally relevant concentration of hormones (30 ng.L-1) was used during laboratory tests. The results obtained through an extensive list of morphological, reproductive and histological parameters showed the significant impact of HSFs on the development and maintenance of exposed fish. The superior efficiency of PAC was verified in relation to the other substrates in the endocrine disrupting chemicals (EDCs) removal in water. Nevertheless, their properties did not guarantee the same performance to the environmental samples, neither allow biological injuries monitored to be recovered after the period of depuration investigated. An additional study also allowed the development of a histochemical protocol capable of identifying the production of vitellogenin (VTG) prompted by exposure to the synthetic steroid EE2.
FAPESP: 2012/24495-6
FAPESP: 2014/22733-2
Wei, Xi. "Environmental screening of endocrine-disrupting chemicals and biological characterization of their effects on reproductive health." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1225.
Full textCassidy, Carrie. "Further evidence that prostaglandin F2-alpha is the obligatory eicosanoid in porcine ovulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0004/MQ44139.pdf.
Full textMelnyk, Peter M. (Peter Michael). "Estrogen regulation of testicular function in the adult ram." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59414.
Full textBiondi, Christine A. "Mouse models of multiple endocrine neoplasia type 1 (MEN 1)." Thesis, Queensland University of Technology, 2002.
Find full textKrown, Kevin Alan. "Pituitary changes in force-molted hens." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185205.
Full textGevrey, Jean-Claude. "Mécanismes de réponse de la cellule endocrine intestinale aux hydrolysats protéiques : aspects sécrétoire et transcriptionnel." Lyon 1, 2002. http://www.theses.fr/2002LYO1T170.
Full textWalls, Gerard V. "Studies of tumourigenesis in the multiple endocrine neoplasia type 1 and hyperparathyroidism-jaw tumour syndromes." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711626.
Full textMohanty, Sanjay K. "Fate and transport of selected endocrine disrupting chemicals in recycled water through a tropical soil." Thesis, Water Resources Research Center, University of Hawaii at Manoa, 2006. http://hdl.handle.net/10125/20489.
Full textHamudikuwanda, Humphrey. "Endocrine and metabolic mediators of dietary energy status and reproduction in dairy cows." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28770.
Full textIn the first two experiments, the concentration of progesterone (P4) in tailhead adipose tissue and plasma in 12 cows at different stages of pregnancy and lactation was determined as was P4 produced in vitro by explants of tailhead adipose tissue. Concentration of P4 in adipose tissue was correlated with that of plasma P4 near estrus and during the luteal phase of the estrous cycle, and P4 was released in vitro by fat mobilization.
In the third and fourth experiments, blood was collected continuously for 16 h from four ovariectomized cows offered maintenance or restricted energy diets after priming with P4 or estradiol (E2) using a crossover experimental design. The results indicated that P4 released during body fat mobilization is minor and is not related to LH secretion. Dietary energy restriction influenced plasma LH concentration and pulse amplitude but the effect was modulated by P4 and E2 priming. Dietary energy restriction decreased glucose concentration but did not influence plasma non-esterified fatty acids (NEFA), cortisol, P4 and insulin levels. Cortisol was negatively related to LH pulse frequency. Glucose and insulin were positively and negatively correlated with LH pulse amplitude, respectively. Cortisol, NEFA and glucose jointly had a negative correlation with LH concentration.
In the fifth experiment, blood samples were collected daily for 60 d and every 10 min for 8 h on 18, 36 and 54 d postpartum from 24 cows (12 ovariectomized) fed low (1.4 Mcal/kg DM) (L) or high (1.7 Mcal/kg DM) (H) energy in a 2 x 2 factorial treatment design. LH pulse frequency was reduced at 18 d postpartum in ovariectomized cows, but not in intact cows, fed L. First postpartum ovulation occurred later in intact cows fed L compared to those fed H. Energy balance and plasma glucose concentration were lower, but plasma NEFA, $ beta$-hydroxybutyrate (BHB) and E2 concentrations higher, in cows fed L compared to those fed H. E2 concentration in intact cows fed L was elevated for a prolonged period prior to first ovulation. Diet had no influence on plasma P4 and insulin concentrations. Plasma E2 and BHB concentrations were positively correlated with LH pulse frequency in intact cows across diets and ovariectomized cows fed L, respectively. NEFA were negatively correlated with LH pulse amplitude in ovariectomized cows fed L. Glucose, NEFA and P4 were negatively, but BHB, E2 and insulin positively correlated, individually or in association, with LH concentration.
Overall, the results suggest that the effect of dietary energy status on LH patterns and timing of onset of postpartum ovulation is modulated by priming with or presence of ovarian steroids. The relationships of metabolites and hormones with LH patterns appear to change with dietary energy level, ovarian status and mutual associations among the metabolites and hormones. These parameters, especially glucose and BHB, may be potential mediators of the effect of dietary energy status on LH patterns. (Abstract shortened by UMI.)
Cote, Fabienne. "Induction of prostaglandin endoperoxide synthase 2 in the follicles of equine chorionic gonadotropinhuman chorionic gonadotropin treated prepubertal gilts." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33741.
Full textAlgire, James Edgar. "Prostaglandins in follicular development and ovulation in cattle." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61849.
Full textFerasyi, Teuku Reza. "Mathematical model of the reproductive endocrine system in male sheep." University of Western Australia. School of Animal Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0080.
Full text陳展豪 and Chin-ho Chan. "Signalling pathways of M918T RET mutant in multiple endocrine neoplasia type 2B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34603244.
Full textSpaulding, Benjamin W. "Endocrine Disruption in Atlantic Salmon (Salmo salar) Exposed to Pesticides." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/SpauldingBW2005.pdf.
Full textGuldstrand, Marie. "Endocrine aspects of obesity and weight reduction by bariatric surgery with special emphasis on beta cell function /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-631-6/.
Full textZhang, Song. "Peripheral and central pathways linking metabolic status and reproduction in male sheep." University of Western Australia. School of Animal Biology, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0037.
Full textMootoo, Judy E. (Judy Elizabeth). "Lipoxygenase metabolites of arachidonic acid in the porcine ovulatory process." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22779.
Full textGrant, Gerald F. "The association between prostaglandins and the plasminogen activator/plasmin system in the porcine ovulatory process /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69759.
Full textKwan, Ivy. "The effect of ACTH and steroidal antiinflammatory agents on prostaglandin F2a levels in vivo and in vitro using a spontaneously established porcine granulosa cell line /." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61233.
Full textIn vitro studies were conducted with a spontaneously established cell line developed through continuous culturing of primary granulosa cells collected from prepuberal gilts six hours after they had received PMSG. Characterization of these cells revealed that aromatase and steroidogenesis were functional but gonadotropin receptors were not present. When extracellular PGF2$ alpha$ levels were measured, dexamethasone was able to significantly suppress PGF$ sb{2 alpha}$ concentrations, but not as effectively as with indomethacin. (Abstract shortened by UMI.)
Mahomed, Shenaaz Ismail. "Descriptive study of the oestrogenicity of run off water from small-sized industry in the Pretoria West area /." Diss., Access to E-Thesis, 2004. http://upetd.up.ac.za/thesis/available/etd-06132005-133600/.
Full textHöybye, Charlotte. "Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-645-6/.
Full textLeung, Chun-to, and 梁鎮濤. "Cellular and molecular characterization of mammary tumor development in wild type and adiponectin deficient MMTV-PyVT mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50712640.
Full textpublished_or_final_version
Pharmacology and Pharmacy
Master
Master of Medical Sciences
Pacelli, Myra Mary. "TEMPORAL RELATIONSHIPS BETWEEN DIETARY LIPIDS AND PITUITARY RESPONSE TO EXOGENOUS GONADOTROPIN RELEASING HORMONE IN HOLSTEIN HEIFERS (LUTEINIZING, PROTECTED FAT, PROGESTERONE)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275374.
Full textDromey, Jasmin Rachel. "Elucidating novel aspects of hypothalamic releasing hormone receptor regulation." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0133.
Full textSchmitt, Matthias. "Endocrine and paracrine aspects of vascular control : the effects of natriuretic peptides on human capacitance in health and chronic heart failure." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55541/.
Full textManning, Katherine L. "The influence of hormone suppression therapy and related factors on bone mineral density in cancer patients." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1399326.
Full textSchool of Physical Education, Sport, and Exercise Science
Nguyen, Tuan-Anh Thi. "Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44653.
Full textXu, Genbo, and 徐亘博. "An integrated environmental risk assessment for marine protected areas in Hong Kong with special reference to the ecological impacts of endocrine disrupting chemicals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208575.
Full textJohnson, Mark Steven 1955. "EFFECTS OF ELEVATING BLOOD LIPIDS IN ENERGY DEFICIENT ANESTROUS DAIRY HEIFERS ON PITUITARY RESPONSE TO GONADOTROPIN RELEASING HORMONE CHALLENGE." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275384.
Full textGomes, D. G. Thushari Sandamali [Verfasser], and Ludwig [Akademischer Betreuer] Gortner. "Intrauterine Growth Retardation Among Preterms In Sri Lanka : Clinical, Endocrine and Molecular Aspects of Folate Metabolism / D.G. Thushari Sandamali Gomes ; Betreuer: Ludwig Gortner." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2009. http://d-nb.info/1174589787/34.
Full textFernandes, Herman A. "Vitellogenesis in the teleost Brachydanio rerio (Zebra fish) /." Title page, abstract and table of contents only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phF363.pdf.
Full text