Academic literature on the topic 'Enantioselective synthesi'
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Journal articles on the topic "Enantioselective synthesi"
Gualandi, Andrea, Luca Mengozzi, and Pier Cozzi. "Stereoselective SN1-Type Reaction of Enols and Enolates." Synthesis 49, no. 15 (June 13, 2017): 3433–43. http://dx.doi.org/10.1055/s-0036-1588871.
Full textDu, Kang, He Yang, Pan Guo, Liang Feng, Guangqing Xu, Qinghai Zhou, Lung Wa Chung, and Wenjun Tang. "Efficient syntheses of (−)-crinine and (−)-aspidospermidine, and the formal synthesis of (−)-minfiensine by enantioselective intramolecular dearomative cyclization." Chemical Science 8, no. 9 (2017): 6247–56. http://dx.doi.org/10.1039/c7sc01859b.
Full textEnders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (January 1, 2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.
Full textChen, Bo, Xin Liu, Ya-Jian Hu, Dong-Mei Zhang, Lijuan Deng, Jieyu Lu, Long Min, Wen-Cai Ye, and Chuang-Chuang Li. "Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids." Chemical Science 8, no. 7 (2017): 4961–66. http://dx.doi.org/10.1039/c7sc01341h.
Full textSundermann, Tom, Martina Arnsmann, Julian Schwarzkopf, Walburga Hanekamp, and Matthias Lehr. "Convergent and enantioselective syntheses of cytosolic phospholipase A2α inhibiting N-(1-indazol-1-ylpropan-2-yl)carbamates." Org. Biomol. Chem. 12, no. 23 (2014): 4021–30. http://dx.doi.org/10.1039/c4ob00535j.
Full textSathish, Manda, Fabiane M. Nachtigall, and Leonardo S. Santos. "Bifunctional thiosquaramide catalyzed asymmetric reduction of dihydro-β-carbolines and enantioselective synthesis of (−)-coerulescine and (−)-horsfiline by oxidative rearrangement." RSC Advances 10, no. 63 (2020): 38672–77. http://dx.doi.org/10.1039/d0ra07705d.
Full textLiu, Yiyang, Marc Liniger, Ryan M. McFadden, Jenny L. Roizen, Jacquie Malette, Corey M. Reeves, Douglas C. Behenna, et al. "Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation." Beilstein Journal of Organic Chemistry 10 (October 28, 2014): 2501–12. http://dx.doi.org/10.3762/bjoc.10.261.
Full textZhang, Yun, Yibin Xue, Gang Li, Haosen Yuan, and Tuoping Luo. "Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums." Chemical Science 7, no. 8 (2016): 5530–36. http://dx.doi.org/10.1039/c6sc00932h.
Full textT. Mohd Ali, M., and . "Synthesis of -Hydroxy -Proline: Potential for Organocataly-sis Reactions." International Journal of Engineering & Technology 7, no. 4.14 (December 24, 2019): 237. http://dx.doi.org/10.14419/ijet.v7i4.14.27571.
Full textMartin, Stephen F. "Ring-closing metathesis: A facile construct for alkaloid synthesis." Pure and Applied Chemistry 77, no. 7 (January 1, 2005): 1207–12. http://dx.doi.org/10.1351/pac200577071207.
Full textDissertations / Theses on the topic "Enantioselective synthesi"
PELLICCIOLI, VALENTINA. "HETEROHELICENES AS APPEALING CHIRAL SYSTEMS: INNOVATIVE METHODOLOGIES FOR THEIR PREPARATION ALSO IN ENANTIOMERICALLY PURE FORM." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/820983.
Full textBlessley, George Richard. "Enantioselective synthesis and reactivity of benzylic fluorides." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:72cd3684-a339-453c-a9e8-c976ff731a0e.
Full textBaxter, Andrew Douglas. "Enantioselective synthesis of aminotetralins : novel synthetic applications of amino acids." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359328.
Full textSikkander, Mohamed Inthikhab. "Enantioselective synthesis of (+)-majusculone." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 46 p, 2007. http://proquest.umi.com/pqdweb?did=1253510231&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textBoyes, Scott Antony. "Enantioselective synthesis using bromoacetals." Thesis, Sheffield Hallam University, 1998. http://shura.shu.ac.uk/19380/.
Full textEfremov, Ivan V. "Enantioselective total syntheses of Teubrevin G and Teubrevin H and studies toward the Enantioselective Total Synthesis of Vinigrol /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486399160105875.
Full textCHABOCHE, CHRISTOPHE. "Synthese totale enantioselective d'acetogenines d'annonaceae." Paris 11, 1996. http://www.theses.fr/1996PA114804.
Full textAzzouz, Mariam. "Enantioselective synthesis of natural products." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/365571.
Full textThe present thesis deals with the development of methodology for the syntheses of several organic molecules that were selected by their interesting biological properties: the antibiotic AT2433-A1, the glycosidase inhibidor nectrisine and analogs of the anti-viral Cidofovir (Figure 1.1) . Although apparently structurally unrelated, they were envisaged to be synthesized through common high-efficient key steps that involve metal-catalyzed process. Enantioselective Synthesis of nectrisine We explore an enantioselective synthesis of nectrisine based on Pd-catalyzed asymmetric allylic amination, cross-metathesis and dihydroxylation as key steps. Scheme 1 shows the retrosynthesis proposed, where the key synthon is the allylamine 4 which is obtained in high enantiomeric purity by a deracemization process using Pd/DACH as a catalytic system. Cross-metathesis will allow increasing the chain length, and at the same time would provide the aldehyde functionality necessary for formation of the cyclic imine moiety in the final nectrisine. Besides, configuration of double bond resulting from cross-metathesis must be E in order to provide the correct configuration of hydroxyl groups in 2 after the dihydroxylation reaction. The stereoselectivity of this reaction will be controlled by the stereocenter in the molecule, which could be also be enhanced by chiral ligands in a matched double stereodifferentiation process. The asymmetric allylic amination from racemic butadiene monoepoxide using (η3-C3H5)PdCl/DACH-naphtyl system and t-Butyl-benzoyl-imido carboxylate as a N-nucleophile proceeded with excellent yield (98%) and enantioselectivity (97%) to obtain the chiral allylic amine synthon 4. Elongation of the chain of the key chiral allylic imide with ethyl acrylate through cross metathesis using Hoveyda-Grubbs catalyst (5 mol %), proceeded quatitatively to obtain the trans alkene intermediates 3. The installation of the syn diol moiety via dihydroxylation of the alkene proceeded with high yield and good diastereoselectivity with OsO4/TMEDA. Hydrolysis of benzoate group in 2 with LiOH and in situ cyclization led to the lactam. Whose hydroxyl functionalities were fully protected by treatment with TBSCl. Subsequent protection with di-t-butyl dicarbonate (Boc) 2O and Et3N in CH2Cl2 gave desired product in 50% yield. The increased carbonyl electrophilicity resulting from NBoc protection should facilitate the smooth reduction of the lactam, which proceeded by reaction with Super Hydride® at −78°C to give lactol. Enantioselective Synthesis of Cidofovir Analogues In this context, the retrosynthetic proposal is shown in Scheme 2. Cidofovir (HPMPC) analogues could be obtained by double bond reduction of product 7 followed by protecting group cleavage on compound 11. Compound 7 in turn can be synthesized from compound 6 via chain elongation mediated by cross-metathesis reaction. Lastly, chiral synthon 6 could be obtained by a palladium-catalyzed dynamic kinetic asymmetric transformation (DYKAT) from racemic butadiene monoepoxide (5). The asymmetric allylic amination of racemic butadiene monoepoxide with cytosine as N-nucleophile was carried out with (η3-C3H5)PdCl/DACH-naphtyl system to obtain chiral allylic cytosine in 85% yield and 72% ee. The reaction was successfully expanded to other pyrimidine and purine bases, among which adenine afforded chiral allyl adenine in 90% yield and 92% ee. Chain elongation via Ru-cross metathesis of key allylic nucleobases and diethyl allylphosphonate with second generation Grubbs catalyst (5 mol%), produced desired compounds in 92% and 90% yield, respectively. Deprotection of all protecting groups with TMSBr afforded the desired unsaturated acyclic nucleosides 8 and 9 in good yields. Hydrogenation with (H2, /Pd/C) at 3 bar rendered the saturated Cidifovir analogues 10. Approaches to the Enantioselective Synthesis of AT2433-A1 The objective of this work was to explore a new enantioselective method to obtain AT2433-A1 with special focus on the synthesis of the 2, 4-dideoxy-4-amino-xyloside moiety. The retrosynthetic proposal is shown in Scheme 5.6. The aminodeoxysugar (19) could be obtained from 16 by eletrophile-induced cyclization. A key point is the selection of group X, since it must control the regioselectivity of the cyclization to an endo-mode and eventually must behave as a leaving group in a future glycosylation reaction. Amino alcohol 16 could be prepared from allylic amine 13 by dihydroxylation, sulphate formation and elimination. Compound 13 can be synthesized from allyl amine 12 via chain elongation mediated by cross-metathesis reaction. Lastly, chiral allyl amine 12 could be obtained, similarly to the previous chapters, by a palladium-catalyzed dynamic kinetic asymmetric transformation (DYKAT) from the racemic butadiene monoepoxide 5. On the other hand, the intermediate 15 could be also obtained by addition to the Garner aldehyde (18) followed by deprotection of the protecting groups in 17. The asymmetric allylic amination from racemic butadiene monoepoxide using (η3-C3H5)PdCl/DACH-naphtyl system and imide as a nitrogen nucleophile proceeded with good yield (96%) and enantioselectivity (90%). Chain elongation of key chiral allylic amine 12 was carried out by cross metathesis with allyl phenyl sulphide with Hoveyda-Grubbs catalyst (5 mol%) to obtain the corresponding trans alkene 13 in 80% yield. The installation of the diol moiety with OsO4 was unsuccesful, due to the competitive oxidation of sulfur, preventing the completion of the synthesis.
Adams, David J. "Enantioselective synthesis of cyclic imides." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342485.
Full textBromhead, Liam Joseph. "Enantioselective Synthesis of Strigolactone Analogues." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16114.
Full textBooks on the topic "Enantioselective synthesi"
Červinka, Otakar. Enantioselective reactions in organic chemistry. London: E. Horwood, 1995.
Find full textHodgson, David M., ed. Organolithiums in Enantioselective Synthesis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0.
Full textMehta, Daxa. Enantioselective synthesis of sulphoxides. Salford: University of Salford, 1989.
Find full textMahrwald, Rainer. Enantioselective Organocatalyzed Reactions I: Enantioselective Oxidation, Reduction, Functionalization and Desymmetrization. Dordrecht: Springer Science+Business Media B.V., 2011.
Find full textBaxter, Andrew Douglas. Enantioselective synthesis of aminotetralins: Novel synthetic applications of amino acids. Norwich: University of East Anglia, 1994.
Find full textHo, Tse-Lok. Enantioselective synthesis: Natural products from chiral terpenes. New York: Wiley, 1992.
Find full textEusebio, Juaristi, ed. Enantioselective synthesis of [beta]-amino acids. New York: Wiley-VCH, 1997.
Find full textI, Dalko Peter, ed. Enantioselective organocatalysis: Reactions and experimental procedures. Weinheim: Wiley-VCH, 2007.
Find full textDalko, Peter I. Enantioselective organocatalysis: Reactions and experimental procedures. Weinheim: Wiley-VCH, 2007.
Find full textJuaristi, Eusebio, and Vadim A. Soloshonok, eds. Enantioselective Synthesis of β-Amino Acids. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471698482.
Full textBook chapters on the topic "Enantioselective synthesi"
Uzir, Mohamad Hekarl. "Enantioselective Synthesis." In Encyclopedia of Membranes, 700. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_2070.
Full textUzir, Mohamad Hekarl. "Enantioselective Synthesis." In Encyclopedia of Membranes, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_2070-1.
Full textNormant, Jean F. "Enantioselective Carbolithiations." In Organolithiums in Enantioselective Synthesis, 287–310. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_9.
Full textMarqués-López, Eugenia, and Raquel P. Herrera. "Organocatalysis in Total Synthesis." In Comprehensive Enantioselective Organocatalysis, 1359–83. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527658862.ch44.
Full textWang, Qian, Jieping Zhu, and Mei-Xiang Wang. "Enantioselective Passerini Reaction." In Asymmetric Synthesis II, 95–101. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527652235.ch13.
Full textHodgson, David M., and Matthew A. H. Stent. "Overview of Organolithium-Ligand Combinations and Lithium Amides for Enantioselective Processes." In Organolithiums in Enantioselective Synthesis, 1–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_1.
Full textGoldfuss, Bernd. "Enantioselective Addition of Organolithiums to C=O Groups and Ethers." In Organolithiums in Enantioselective Synthesis, 21–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_2.
Full textIguchi, Mayu, Ken-ichi Yamada, and Kiyoshi Tomioka. "Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents." In Organolithiums in Enantioselective Synthesis, 37–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_3.
Full textHoppe, Dieter, Felix Marr, and Markus Brüggemann. "Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation." In Organolithiums in Enantioselective Synthesis, 61–138. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_4.
Full textBeak, Peter, Timothy A. Johnson, Dwight D. Kim, and Sung H. Lim. "Enantioselective Synthesis by Lithiation Adjacent to Nitrogen and Electrophile Incorporation." In Organolithiums in Enantioselective Synthesis, 139–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36117-0_5.
Full textConference papers on the topic "Enantioselective synthesi"
Bagnoli, Luana, Marcello Tiecco, Lorenzo Testaferri, Catalina Scarponi, Andrea Temperini, Francesca Marini, and Claudio Santi. "Selenium Promoted Enantioselective Synthesis of Spiroketals." In The 9th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01519.
Full textCarrillo Fernández, Luisa, Jose Luis Vicario, Iker Riaño, Estibaliz Diaz, Efraim Reyes Martín, and Uxue Uria. "Enantioselective Synthesis of Chiral Proline Derivatives." In MOL2NET 2016, International Conference on Multidisciplinary Sciences, 2nd edition. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/mol2net-02-h004.
Full textEames, Jason, Ewan Boyd, Alastair Hay, Ray Jones, Rachel Stenson, and Michael Suggate. "Enantioselective Protonation of Prostereogenic Enol Equivalents." In The 10th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01388.
Full textCorreia, Carlos Roque Duarte. "Enantioselective Heck Reactions with Aryldiazonium Salts. Challenges and Synthetic Opportunities." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-speech15.
Full textBarabás, Béla, Luciano Caglioti, Francesco Faglioni, Nicola Florini, Paolo Lazzeretti, Marco Maioli, Károly Micskei, et al. "On the Traces of Absolute Enantioselective Synthesis." In COMPUTATIONAL METHODS IN SCIENCE AND ENGINEERING: Theory and Computation: Old Problems and New Challenges. Lectures Presented at the International Conference on Computational Methods in Science and Engineering 2007 (ICCMSE 2007): VOLUME 1. AIP, 2007. http://dx.doi.org/10.1063/1.2835949.
Full textSilva, Tiago Lima da, and Paulo Henrique Schneider. "Multicomponent Synthesis of Bifunctional Thiourea Organocatalysts for the Enantioselective Aldol Reaction." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0012-1.
Full textSoares, Liliana A., Helena D. de Salles, and Paulo H. Schneider. "Highly enantioselective arylation of aromatic aldehydes, promoted by chiral phosphinite ligands." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0018-1.
Full textWosch, Celso L., Francisco A. Marques, Gustavo Frensch, Ricardo Labes, Beatriz Helena L. N. Sales Maia, Cesar A. Lenz, and Palimecio G. Guerrero Jr. "Chiral -Hydroxyalkyloxazolines as Ligands in the Enantioselective Addition of Diethylzinc to Aldehydes." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0251-1.
Full textManoel*, Evelin A., Maria Alice Z. Coelho, Rodrigo O. M. A. de Souza, Alessandro B. C. Simas, and Denise M. G. Freire. "Enantioselective catalysis from Pseudomonas cepacia on the kinetic resolution by different reactors." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201383123328.
Full textSakae, George H., Leandro M. Takata, Antonio S. Paulino, Reinaldo C. Bazito, Rafael F. Cassaro, Cleverson Princival, and Alcindo A. Dos Santos. "A high enantioselective Proline-based helical polymer catalyst for aldol type reaction." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013912163332.
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