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1

Ilangamge, S., and D. M. S. Handagala. "Review of the management of empyemas." Ceylon Journal of ECMO, Cardiothoracic Surgery and Critical Care 1, no. 1 (May 17, 2024): 25–32. http://dx.doi.org/10.4038/cjecc.v1i1.4.

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An empyema is a collection of pus in the pleural cavity. It is a serious pathological condition of the pleural space and it can have high morbidity and mortality rates. The most frequent cause of empyema is infection stemming from a parapneumonic effusion. Special challenges in management arise with post-surgical empyemas and those linked to Tuberculosis. This article concentrates on addressing the management of parapneumonic effusions/empyemas.
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Imburgio, Steven, Kameron Tavakolian, Anton Mararenko, Tasfia Tasnim, Taimoor Khan, and Eric Costanzo. "Empyema Versus Lung Abscess: A Case Report." Journal of Investigative Medicine High Impact Case Reports 10 (January 2022): 232470962211392. http://dx.doi.org/10.1177/23247096221139268.

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Lung abscesses and empyemas are 2 forms of pulmonary infection that can present with similar clinical features. However, empyemas are associated with higher morbidity and mortality, necessitating the need to distinguish one from the other. Plain radiographs can sometimes provide clues to help differentiate the 2 pathologies but more often than not, a computed tomography scan is required to confirm the diagnosis. Correct diagnosis is essential, as the goal standard therapeutic intervention for empyemas may be contraindicated in patients with lung abscesses. Empyemas require percutaneous or surgical drainage in combination with antibiotics, while lung abscesses are generally treated with antibiotics alone as drainage can be associated with various complications. We present a case of a 65-year-old man with parapneumonic empyema diagnosed with characteristic findings on chest computed tomography and treated with surgical drainage and antibiotics. We hope to improve patient outcomes by highlighting the classical radiographic findings that help distinguish empyema and abscess.
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3

Coates, Anne, Oren Schaefer, Karl Uy, and Brian P. O'Sullivan. "Empyema in a Woman with Cystic Fibrosis: A Cautionary Tale." Case Reports in Pulmonology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/159508.

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Cystic fibrosis (CF) is a disease which predisposes individuals to recurrent infective exacerbations of suppurative lung disease; however, empyema is a rare complication in these patients. Empyemas secondary toStaphylococcus aureusandBurkholderia cepaciahave been described in patients with CF. We report the case of pleural empyema with mixedS. aureusandPseudomonas aeruginosainfection in a 34-year-old woman with CF, which was managed with ultrasound-guided pigtail catheter insertion, fibrinolysis, and antibiotic therapy. Physicians should be aware of this unusual complication in CF patients, especially those receiving an immunosuppressive therapy.
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4

Medford, ARL, YM Awan, A. Marchbank, J. Rahamim, J. Unsworth-White, and PJK Pearson. "Diagnostic and Therapeutic Performance of Video-Assisted Thoracoscopic Surgery (Vats) in Investigation and Management of Pleural Exudates." Annals of The Royal College of Surgeons of England 90, no. 7 (October 2008): 597–600. http://dx.doi.org/10.1308/003588408x318246.

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INTRODUCTION Video-assisted thoracoscopic surgery (VATS) is the gold standard investigation for diagnosis of pleural exudates. It is invasive and it is important to ensure that it is performed to acceptable national standards. We assumed that VATS empyema fluid culture would not contribute further to microbiological diagnosis in referred culture-negative empyemas. PATIENTS AND METHODS Eighty-six consecutive external referrals for VATS for diagnosis of a cytology-negative pleural exudate (or for further management of the exudate) were studied retrospectively. Diagnostic yield, pleurodesis efficacy and complications were compared to national standards and good practice recommendations. VATS empyema fluid microbiological culture results were compared to pre-VATS empyema fluid culture results. RESULTS VATS was performed well within national standards with a diagnostic yield of 82.3% for cytology-negative exudates, 100% pleurodesis efficacy, 5.8% postoperative fever, with only one significant complication (1.2% rate) and no deaths. Compliance with good practice pleural fluid documentation points was greater than 70%. VATS empyema fluid culture positivity (84.6%) was significantly higher than pre-VATS fluid culture (35%). CONCLUSIONS VATS was performed to acceptable standards. These data confirm the utility and safety of VATS in the right context but also suggest the potential diagnostic utility of VATS empyema fluid culture. Further studies are required to investigate this latter possibility further.
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5

Swaminathan, Neeraja, Katherine Anderson, Joshua D. Nosanchuk, and Matthew J. Akiyama. "Candida glabrata Empyema Thoracis—A Post-COVID-19 Complication." Journal of Fungi 8, no. 9 (August 30, 2022): 923. http://dx.doi.org/10.3390/jof8090923.

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The COVID-19 pandemic is associated with a significant increase in the incidence of invasive mycosis, including pulmonary aspergillosis, mucormycosis, and candidiasis. Fungal empyema thoracis (FET) is an uncommon clinical presentation of invasive fungal disease (IFD) associated with significant mortality. Here, we describe the first report of a patient with post-COVID-19 multifocal necrotizing pneumonia complicated by a polymicrobial empyema that included Candida glabrata. Candida empyemas represent another manifestation of a COVID-19-associated fungal opportunistic infection, and this infrequently encountered entity requires a high degree of clinical suspicion for timely identification and management. Therapy for empyemas and other non-bloodstream Candida infections may differ from candidemia due to several pharmacokinetic parameters impacting bioavailability of the antifungal in the affected tissue (e.g., pleural space) and is an area that needs more investigation.
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6

Keeling, W. Brent, Joseph R. Garrett, Nasreen Vohra, Thomas S. Maxey, Elizabeth Blazick, and K. Eric Sommers. "Bedside Modified Clagett Procedure for Empyema after Pulmonary Resection." American Surgeon 72, no. 7 (July 2006): 627–30. http://dx.doi.org/10.1177/000313480607200710.

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The objective of this study is to demonstrate the effectiveness and feasibility in treating empyema after pulmonary resection with a modified Clagett procedure performed at the bedside (BMCP). A retrospective review of a single surgeon's experience at a single institution was undertaken. All operative, postoperative, and outcome data were analyzed. Follow-up data were obtained from subsequent clinic charts. Five patients, including four males, were identified who underwent BMCP after pulmonary resection. The original operative procedures included two lobectomies, one pneumonectomy, one bilobectomy, and one bilateral metastastectomy. Patients were diagnosed with an empyema (positive thoracostomy tube culture, fever, and radiographic abnormality) at a mean time of 31 days from their initial procedure. Culture results disclosed Gram-positive empyemas in all patients. Three patients underwent BMCP as an outpatient, whereas the other two had BMCP during their hospitalizations. All patients are free from complications or recurrence at a mean follow up of 11.2 months. No patient required a further procedure after BMCP. The bedside modified Clagett procedure is both safe and effective. It is a valuable option in the management of postoperative empyema because it avoids additional operative procedures. This procedure is cost-effective when compared with operative management of perioperative empyema.
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7

Mohamed, Lazraq, Bensaid Abdelhak, Miloudi Youssef, and Elharrar Najib. "Cerebral Empyema Complicating a Dental Abscess." General Medicine and Clinical Practice 2, no. 1 (July 17, 2019): 01–03. http://dx.doi.org/10.31579/2639-4162/017.

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Cervico-facial cellulitis can cause serious complications including neuro-meningeal infections. Among these neuro-meningeal infections are intracranial empyemas, which are rarer than brain abscesses. We report the case of a young patient of 25 years, immunocompetent, having presented a cerebral empyema secondary to diffuse cervicofacial cellulitis of dental origin. The diagnosis was suspected in the presence of cervicofacial cellulitis, febrile meningeal syndrome and consciousness disorder, confirmation was reported by brain MRI. The evolution was favorable after the recourse to the surgical treatment.
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8

Khatomkin, D. M., A. A. Vorobev, I. A. Vorobev, N. V. Komissarova, and A. V. Kobelev. "Surgical treatment of a patient with purulent frontal sinusitis and falcotentorial empyema." Russian journal of neurosurgery 25, no. 1 (March 30, 2023): 78–84. http://dx.doi.org/10.17650/1683-3295-2023-25-1-78-84.

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Background. Subdural empyemas are accumulation of pus between the dura mater and the arachnoid mater of the brain. They represent 12–25 % of all intracranial purulent‑inflammatory diseases. 70–80 % of them are located convexitaly and 10–20 % in the area of the falx cerebri. A spread of pus on the tentorium cerebellum occurs rare. Without timely treatment, that includes massive therapy with antibiotics and drainage of the subdural empyema, most of the patients die in the result of progression of the secondary purulent meningoencephalitis and dislocation of the brain.Аim. To report the case of subdural empyema of rare localization – in the left part of the interhemispheric fissure and supratentorial space, to demonstrate the effectiveness of prolonged continuous flow drainage in treatment of the subdural empyema in this particular case.Materials and methods. 16‑year‑old patient was admitted into the neurosurgical department of the 1‑st Republican clinical hospital of the Izhevsk city with pronounced general infectious and meningeal syndrome and paresis of the muscles of his right shin and foot. CT scans revealed frontal sinusitis and subdural empyema of the left part of the interhemispheric fissure and the supratentorial space. In addition to intravenous antibacterial therapy with vancomicyn and Meronem bifrontal cranioectomy, debridement of the frontal sinus, obliteration of it’s residual cavity with free muscle graft and external drainage of the subdural empyema with following continuous irrigation during 6 days after surgery had been performed. At the time of discharge from the neurosurgical department 16 days after the operation complete regress of the general infectious and meningeal syndrome was observed.Results. On control examination 44 days after the surgery the patient’s condition was normal and he had no neurolog ical deficit. On the series of MRI scans preformed 6 months latter, after the cranioplasty, no remnants of the subdural empyema were revealed.Conclusions. This clinical case demonstrates the effectiveness of the prolonged continuous flow drainage in combination with systemic antobioticotherapy and elimination of the primary source of infection within the frontal sinus in treatment of the large and deeply situated subdural empyema of rare falcotentorial localization.
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9

Anthonisen, Nick R. "Empyema." Canadian Respiratory Journal 15, no. 2 (2008): 69–70. http://dx.doi.org/10.1155/2008/927191.

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10

Parry, Wyn. "Empyema." Surgery (Oxford) 22, no. 5 (May 2004): 103–5. http://dx.doi.org/10.1383/surg.22.5.103.33381.

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11

Borovich, Bernardo, Elizabeth Johnston, and Edgardo Spagnuolo. "Infratentorial subdural empyema: clinical and computerized tomography findings." Journal of Neurosurgery 72, no. 2 (February 1990): 299–301. http://dx.doi.org/10.3171/jns.1990.72.2.0299.

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✓ Infratentorial subdural empyemas are rare. The authors report three cases encountered between 1979 and 1988, representing a 3% incidence among all subdural empyemas. The common source was an ear infection. Clinical presentation encompassed a systemic febrile illness, headaches, and a stiff neck. Only one patient had an inconspicuous focal neurological deficit that suggested a cerebral location. Initial diagnosis was acute meningitis in each case. A lumbar puncture was ordered in all three cases but was actually performed in two without developing tonsillar herniation. Cerebrospinal fluid analysis confirmed the diagnosis of meningitis in one but was normal in the other. Computerized tomography allowed a precise diagnosis and localization of the pathology. All three patients received aggressive antibiotic therapy plus suboccipital craniectomy and aspiration of pus; catheter drainage was performed in two. Cultures were positive in one case and negative in the others. Two patients were cured without sequelae; the third patient was moribund at surgery and died. Although it is known that subdural empyemas may localize in the posterior fossa, only one previous report was found. Infratentorial subdural empyema may sometimes be an unrecognized companion of acute meningitis and is cured with antibiotic therapy alone.
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12

Sari, Dinda Puspita, Elvienna Shaffiranisa, Amrullah Muliawan Hamdin, Clara Nadila, and Philip Habib. "Gallbladder Empyema: A Dreadly Complication of Acute Cholecystitis." Jurnal Biologi Tropis 23, no. 1 (November 1, 2023): 1–6. http://dx.doi.org/10.29303/jbt.v23i1.5783.

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Gallbladder empyema is a severe form of acute cholecystitis with additional suppuration with an incidence rate of 6.3%-26.6% and a mortality rate 3%. If not treated promptly, gallbladder empyema can cause complications. Therefore, in this literature review we will discuss gallbladder empyema in more depth and the immediate treatment that must be carried out to avoid complications in patients. In this literature review Schoolar, we conducted a search on the PubMed and Sciencedirect database using the search keyword “gallbladder empyema”, “empyema”, and “gallbladder”. Gallbladder empyema can occur due to bile that cannot be excreted from the gallbladder will cause infection from microorganisms so that the gallbladder becomes full of exudative material in the form of pus, causing acute inflammation. Diagnosis of gallbladder empyema can be done using Ultrasonography and Computed Tomography Scan (CT Scan). Percutaneous transhepatic gallbladder drainage (PTGBD) is a procedure for the initial management of gallbladder empyema before laparoscopic cholecystectomy. If gallbladder empyema is treated immediately, the prognosis is good. If not treated promptly, gallbladder empyema can lead to peritonitis, and bacteremia leading to a rapid systemic inflammatory response, shock, and sepsis.
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13

Weber, J., D. Gräbner, K. Al-Zand, and D. Beyer. "Empyema after Pneumonectomy - Empyema Window or Thoracoplasty?" Thoracic and Cardiovascular Surgeon 38, no. 06 (December 1990): 355–58. http://dx.doi.org/10.1055/s-2007-1014049.

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14

Desimonas, Nicholas A., Athanassios L. Hevas, and Nikolaos Tsilimingas. "Chronic tension empyema or chronic expanding empyema?" Asian Cardiovascular and Thoracic Annals 21, no. 4 (July 15, 2013): 500. http://dx.doi.org/10.1177/0218492313492522.

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15

Lam, Sherrell T., Michael L. Johnson, Ryan M. Kwok, and John T. Bassett. "Spontaneous Bacterial Empyema: Not Your Average Empyema." American Journal of Medicine 127, no. 7 (July 2014): e9-e10. http://dx.doi.org/10.1016/j.amjmed.2014.01.034.

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16

Yu, Gannon J., Harvey R. Rabin, and Michael D. Parkins. "Case Report—Aspergillus Empyema Necessitans Post Double-lung Transplant." US Respiratory & Pulmonary Diseases 01, no. 01 (2016): 19. http://dx.doi.org/10.17925/usrpd.2016.01.01.19.

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Empyema necessitans (also called empyema necessitatis) is a sequelae of empyema/parapneumonic effusion where infection progresses beyond the pleural space into the soft tissues of the chest wall. Typical pathogens includeMycobacterium tuberculosis,Streptococcus pneumoniae, andStaphylococcus aureus. Fungal empyema necessitans is uncommon, with the majority of cases secondary to Candida species. We report a rare and fatal case of empyema necessitans presenting in a patient with cystic fibrosis more than 10 years following double-lung transplant.
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17

Lee, Wei-Ju, Ming-Horng Tsai, Jen-Fu Hsu, Shih-Ming Chu, Chih-Chen Chen, Peng-Hong Yang, Hsuan-Rong Huang, Miao-Ching Chi, Chiang-Wen Lee, and Mei-Chen Ou-Yang. "The Epidemiology, Management and Therapeutic Outcomes of Subdural Empyema in Neonates with Acute Bacterial Meningitis." Antibiotics 13, no. 4 (April 21, 2024): 377. http://dx.doi.org/10.3390/antibiotics13040377.

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Background: Subdural empyema is one of the more serious complications of bacterial meningitis and therapeutic challenges to clinicians. We aimed to evaluate the clinical characteristics, treatment, and outcome of subdural empyema in neonates with bacterial meningitis. Methods: A retrospective cohort study was conducted in two medical centers in Taiwan that enrolled all cases of neonates with subdural empyema after bacterial meningitis between 2003 and 2020. Results: Subdural empyema was diagnosed in 27 of 153 (17.6%) neonates with acute bacterial meningitis compared with cases of meningitis without subdural empyema. The demographics and pathogen distributions were comparable between the study group and the controls, but neonates with subdural empyema were significantly more likely to have clinical manifestations of fever (85.2%) and seizure (81.5%) (both p values < 0.05). The cerebrospinal fluid results of neonates with subdural empyema showed significantly higher white blood cell counts, lower glucose levels and higher protein levels (p = 0.011, 0.003 and 0.006, respectively). Neonates with subdural empyema had a significantly higher rate of neurological complications, especially subdural effusions and periventricular leukomalacia. Although the final mortality rate was not increased in neonates with subdural empyema when compared with the controls, they were often treated much longer and had a high rate of long-term neurological sequelae. Conclusions: Subdural empyema is not uncommon in neonates with acute bacterial meningitis and was associated with a high risk of neurological complications, although it does not significantly increase the final mortality rate. Close monitoring of the occurrence of subdural empyema is required, and appropriate long-term antibiotic treatment after surgical intervention may lead to optimized outcomes.
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18

SALEEM, MUHAMMAD, MUHAMMAD ASIF QURESHI, and MUHAMMAD ASIF I. QURESH. "EMPYEMA THORACIS." Professional Medical Journal 17, no. 03 (September 10, 2010): 464–71. http://dx.doi.org/10.29309/tpmj/2010.17.03.2838.

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Empyema as a complication of community acquired pneumonia (CAP) is relatively common occurrence in developing countries. Study Design: Prospective study. Period: 4 year Jan 2001- Dec 2004. Setting: Department of Pediatric surgery the Children’s hospital Lahore. Patients & Method: A total of 114 cases of empyema thoracic secondary to CAP were dealt with during this period, while in the same duration a total of 1768 cases of pneumonia were treated at the Children’s hospital Lahore. Results: Majority of the patients with CAP (59.61%) were below one year of age whereas the patients who developed empyema, were mainly (45.67%) between 2 to 5 years of age. Patients above 5 years of age having CAP (31.70%) and having repeated attacks of respiratory tract infection were most susceptible to develop empyema. Staphylococcus aureus was the most common organism found (40.35%) in this series. Vaccination, poverty and gender did not significantaffected the development of empyema among the patients of CAP. Antibiotic resistance had no role in the development of empyema. Ibuprofen may be a risk factor. All the patients were initially managed with tube thoracostomy and antibiotics. Forty-eight patients (42.10%) needed subsequently operative management. Three patients (2.63%) had fatal course in this series same as seen in patients of CAP (2%). Conclusions: Immunization against causative organism and modification of out patient treatment may affect the incidence of empyema in children and should be studied prospectively.
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19

Dutta, Deep, Shameem Ahmed, and Abhigyan Borkotoky. "Spontaneous Subdural Empyema: A Case Report." Asian Journal of Neurosurgery 18, no. 04 (December 2023): 823–25. http://dx.doi.org/10.1055/s-0043-1777273.

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AbstractSubdural empyema is the collection of purulent material between the dura mater and arachnoid. Subdural empyema most often occurs due to the direct extension of local infection. But spontaneous subdural empyema is a rare entity. In literature, not many cases of spontaneous subdural empyema by Escherichia coli are reported. Here we report a case of spontaneous subdural empyema along with a review of literature who was previously treated on the suspicion of encephalitis with urinary tract infection and then brought to our hospital.
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20

P. S., Sony, Vinu C. V., Suresh Kumar J., and Kishore Lal. "Thoracic empyema: clinical course and management in Trivandrum Medical College." International Journal of Research in Medical Sciences 9, no. 9 (August 25, 2021): 2681. http://dx.doi.org/10.18203/2320-6012.ijrms20213407.

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Background: The incidence of empyema thoracis among adults is increasing steadily. It may be primary empyema (pleural infection developing without pneumonia) or secondary empyema. The common cause of secondary empyema being- community acquired pneumonia or hospital acquired pneumonia, empyema due to iatrogenic causes, secondary to trauma etc. With advancement in science and technology, early recognition of empyema in patients with symptoms is now possible. But the treatment guidelines are not unified so that each physician may treat this condition in a different way without referring to higher concerned specialties making it complicated. The objective of this study was to determine the clinical profile of thoracic empyema in Trivandrum Medical College a tertiary care centre in South Kerala.Methods: A total of 56 patients with empyema admitted to Government Medical College, Trivandrum, Kerala in 2018-2019 were reviewed retrospectively. The demographic details, clinical presentation, etiology, microbiological findings, and management were recorded in a planned proforma, and analysis was done.Results: The mean age was 49.1 years with peak incidence seen in 40-60 years of age. The male to female ratio was 4.6:1.0 and right pleura was more involved than left pleura. Risk factors were diabetes mellitus, chronic obstructive pulmonary disease, pulmonary tuberculosis, and smoking. Etiology of thoracic empyema was infective in 78.6% cases and traumatic in 21.4% cases. Only two cultures showed gram positive aerobe, rest of the culture was sterile. Only a few cases resolved with medical management. Decortication was needed for 52 patients (82.1%).Conclusions: A unified protocol need to be formulated and followed up in all centres for the management of empyema before its evolution and thus reducing the incidence of empyema and its associated complications.
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21

Aalloula, K., A. Diani, S. Abouliatim, B. Boutakiout, M. Ouali El Idrissi, and N. Cherif El Idrissi Ganouni. "Empyema Necessitatis Due to Streptococcus pneumoniae: Case Report." Scholars Journal of Medical Case Reports 10, no. 8 (August 27, 2022): 840–42. http://dx.doi.org/10.36347/sjmcr.2022.v10i08.023.

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Empyema necessitatis is a rare complication of empyema characterized by extension of suppuration from the pleural space through the chest wall. The most common etiologies are tuberculosis and actinomycosis. We describe a 60-year-old woman with Streptococcus pneumoniae empyema necessitatis. Empyema necessitans should be kept in the differential diagnosis of patients with left chest masses or abscesses.
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22

Prasada Rao, M. Surya, and P. Satish Chandra. "A study of paediatric empyema thoracis presentation in a tertiary care hospital in Visakhapatnam, India." International Journal of Contemporary Pediatrics 5, no. 2 (February 22, 2018): 572. http://dx.doi.org/10.18203/2349-3291.ijcp20180557.

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Background: Empyema thoracis is an accumulation of pus in the pleural space. The incidence of empyema in children is increasing. Adequate knowledge of treatment modalities is therefore essential for every pediatrician. Pediatric empyema thoracis is a complication of bacterial pneumonia, prevalence of empyema is predominant inspite of advent newer antibiotics still resulting in significant morbidity and mortality which attributes to the poverty, ignorance, illiteracy, and poor compliance to therapy. The objective of this study was to study the age-sex profile, clinical presentation, etiologic agents, management and the overall treatment outcome of empyema thoracis in children.Methods: This was a prospective observational study, conducted in the Department of Pediatrics, King George Hospital, Visakhapatnam, from November 2014 to December 2016. All children in age group of 0 to 12 years diagnosed pyogenic empyema during the study period were included in the present study. In the present study 72 children was found to be having empyema.Results: Majority of patients (58.32%) were seen in age group of 1-5 years. Fever (100%), breathlessness (94.44%), and cough (97.22%) were the commonest presenting features. Bacteriological examination revealed staphylococcus aureus as the commonest etiologic agent (16.66%) isolated from pleural fluid culture. All patients were treated with antibiotics, and drainage of the empyema was affected by closed thoracostomy in (80.55%) of the cases. Conclusion: Empyema is not rare in our practice. Early diagnosis and proper treatment of pneumonia prevent the development of empyema. Antibiotics and tube thoracostomy is an effective method of treating pyogenic empyema thoracis in children in resource poor settings.
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El Gazzar, Ahmad G., Mohammad A. E. El-Mahdy, Gehan F. Al Mehy, and Asmaa El Desoukey Mohammad. "The role of medical thoracoscopy in the management of empyema." Egyptian Journal of Bronchology 13, no. 1 (February 13, 2019): 55–62. http://dx.doi.org/10.4103/ejb.ejb_44_18.

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Abstract Background Empyema thoracis is defined as accumulation of pus in the pleural space. Despite advanced medical diagnostic and therapeutic methods, thoracic empyema remains a common clinical entity and a serious problem all over the world with significant associated morbidity and mortality. Aim The aim of this work was to study the efficacy and safety of medical thoracoscopy (MT) in the management of empyema. Patients and methods This study included 30 inpatients with empyema. Included patients had frank pus on aspiration (turbid purulent fetid fluid) with or without positive Gram stain smear and microbiological culture findings or pH less than 7.20, with signs of sepsis. Patients were managed by MT. MT using rigid thoracoscopy was performed with evacuation of the purulent fluid, visualization of the pleural space, assessment of adhesions and purulent material, forceps adhesiolysis, and irrigation by normal saline with partial debridement of accessible parietal pleural surface. Results The present study included 30 patients with empyema (17 men, 13 women with a mean age of 47.4±14.5 years; range, 18–70 years); 19 (63.3%) patients had free-flowing empyema (by computed tomography/ ultrasonography) and 11 (36.7%) patients had multiloculated empyema. The etiology of empyema included pneumonia (parapneumonic effusion) (33.3%), malignancy (23.3%), tuberculosis (6.7%), lung abscess (6.7%), and no cause was identified in nine patients (spontaneous pleural infection) (30%). MT was considered successful without subsequent interventional procedures in 26 of 30 (86.7%) patients, including all patients with free-flowing empyema (19 patients), 63.6% of patients with multiloculated empyema (seven patients), and four (13.3%) patients required surgical intervention (surgical decortication). No procedure-related mortality or chronic morbidity occurred in this study. Conclusion MT is a simple, safe, minimally invasive, and effective modality in the management of empyema.
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Mazumdar, J., and S. Sen. "Neonatal Empyema Thoracis." Journal of Nepal Paediatric Society 34, no. 1 (March 24, 2014): 65–67. http://dx.doi.org/10.3126/jnps.v34i1.8233.

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Empyema thoracis, is a rare cause of respiratory distress in neonates. Only a few cases of neonatal empyema thoracis are described in medical literature. Empyema thoracis is not a well known entity in the neonates. It is fulminant with rapid progression with a high mortality. Compounding the problem is its uncertain etiopathogenesis and lack of definite treatment guidelines. We shall describe one case of neonatal empyema in a newborn aged five days caused by Pseudomonas aeruginosa. The neonate died subsequently. DOI: http://dx.doi.org/10.3126/jnps.v34i1.8233 J Nepal Paediatr Soc 2014;34(1):65-67
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Marhana, Isnin Anang, and Amelia Tantri Anggraeni. "Problem Terapeutik pada Empiema Terlokulasi karena Tuberkulosis." Jurnal Respirasi 4, no. 3 (April 7, 2020): 86. http://dx.doi.org/10.20473/jr.v4-i.3.2018.86-93.

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Background: Pleural effusion is the most common complication of pulmonary tuberculosis (TB). Some coexist with secondary infection could worsen clinical presentation as empyema. The incidence of pleural effusion in the early stage of empyema due to TB infection is about 31%. Somehow, untreated empyema increased in-hospital mortality. Case: A woman with unregulated diabetes mellitus was referred with organized empyema. The etiology of empyema is based on a specific process of TB infection with the ADA value of empyema fluid was 128 mg/dl. We decided to perform decortication with the result loculated empyema and bronchopleural fistula 2 cm in the inferior lobe of the right lung. The patient did not recover well. Unfortunately, fluidopneumothorax was found on a chest CT scan with contrast. Thoracotomy was performed and another bronchopleural fistula was found which length was about 1 cm in superior lobe of the right lung. Discussion: The worsening condition of the patient was caused by the occurrence of postoperative bronchopleural fistula. It was visualized as pulmonary TB with perforation of cavity nessessity. On the other hand, the condition could be worsened by the hyperglycemic state in an immunocompromised individual. Summary: Loculated empyema is a condition caused by bronchopleural fistula, the presence of a connecting cavity between pleural and bronchus which occurred less than 48 hours. Local and systemic factors might explain the development of bronchopleural fistula. Well management of the loculated empyema by knowing the etiology could improve the life survival of the patient.
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Böhle, Sabrina, Luise Finsterbusch, Julia Kirschberg, Sebastian Rohe, Markus Heinecke, Georg Matziolis, and Eric Röhner. "Incidence of Secondary Osteoarthritis after Primary Shoulder and Knee Empyema and Its Risk Factors." Journal of Personalized Medicine 14, no. 3 (February 29, 2024): 264. http://dx.doi.org/10.3390/jpm14030264.

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Empyema of the joint is an orthopedic emergency that is associated with a prolonged healing process despite adequate surgical and medical therapy. The risk of developing postinfectious osteoarthritis (OA) after successfully treated joint empyema is unknown. Both incidence and risk factors are important for prognostication and would therefore be clinically relevant for the selection of an adequate infectious therapy as well as for the individual follow-up of patients. The aim of this retrospective clinical study was to describe the risk of secondary OA after empyema based on knee and shoulder joint infections after successful primary infection treatment and its risk factors. Thirty-two patients were examined clinically and radiographically after completion of treatment for primary empyema of the knee or shoulder joint. Patients with previous surgery or injections in the affected joint were excluded from the study. The cumulative incidence of new-onset radiographic OA was 28.6%, representing a 5.5-fold increased risk of developing OA compared to the normal population. A figure of 25% of patients underwent total knee arthroplasty after knee empyema. Identified risk factors for primary empyema were obesity, hyperuricemia, and rheumatoid arthritis. Only about 60% of the patients tested positive for bacteria. Staphylococcus aureus, the most common pathogen causing joint empyema, was present in approximately 40% of cases. Secondary osteoarthritis, as a possible secondary disease after joint empyema, could be demonstrated and several risk factors for the primary empyema were identified.
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27

Torjani, Ava, Dylan Selbst, Joshua Hamsher, Sahaj Mujumdar, Andie Belkoff, and Luis Taboada. "Successful Treatment With Daptomycin of MRSA Empyema Complicated by Right-Sided Loculated Pleural Effusion Refractory to Vancomycin." Clinical Medicine Insights: Case Reports 15 (January 2022): 117954762210785. http://dx.doi.org/10.1177/11795476221078532.

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Empyema is a serious complication of pneumonia and has been reported to have a mortality rate of 8.7%. For methicillin-resistant Staphylococcus aureus (MRSA) empyema, treatment includes drainage and specific antibiotics such as vancomycin and linezolid. Strikingly, there are increasing incidences of empyema refractory to vancomycin and linezolid. Despite being inactivated in the lung parenchyma by pulmonary surfactant, daptomycin can penetrate the pleural space and may be better at treating MRSA empyema than vancomycin and linezolid. Some case reports have shown that daptomycin has been used to successfully treat MRSA empyema refractory to linezolid and vancomycin-resistant enterococcus (VRE) empyema. Here, we present a 26-year-old male with a past medical history of intravenous (IV) drug use, newly diagnosed HIV, HCV, and multifocal pneumonia complicated by a left-sided MRSA empyema that partially resolved with vancomycin and drainage. However, he subsequently developed a right-sided loculated pleural effusion. After the patient was switched to daptomycin with continued drainage, the right and left pleural effusions improved significantly. Once medically stable, he was discharged to a rehabilitation facility for further recovery. Our case report demonstrates that daptomycin could be considered as an effective treatment for MRSA empyema, particularly when refractory to vancomycin.
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28

Hashemian, Houman, and Fina Sanati. "Comparing the Mean Platelet Volume and the Neutrophil-to-Lymphocyte Ratio in Children With Bacterial Pneumonia Associated With or Without Pleural Empyema." Journal of Guilan University of Medical Sciences 31, no. 4 (January 1, 2023): 328–37. http://dx.doi.org/10.32598/jgums.31.3.1813.1.

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Background Pneumonia is one of the severe infections in children, and empyema is one of its essential complications which causes more risk in affected children. Therefore, its early diagnosis is of great importance. Objective This study aims to compare the value of two inflammatory markers including mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) in children with pneumonia associated with and without pleural empyema. Methods This study was conducted on the data of 128 children aged 3 months to 14 years with bacterial pneumonia associated with pleural empyema and 128 children without pleural empyema. The MPV and NLR values and the patients’ demographic and clinical characteristics were analyzed in SPSS software version 18 software. The confidence interval for the area under the ROC curve was calculated using binomial exact method. The significance level was set at 0.05. Results Of 256 children, 42.2% were girls, and most of children had ages <3 years (35.2%). Children with empyema had significantly higher NLR, platelet count, and MPV than children without empyema (P=0.040, 0.005, and 0.021, respectively). The MPV (P=0.020) and NLR (P=0.039) were significant predictors of empyema. Conclusion The use of NLR and MPV may be useful in the early diagnosis of empyema in children with pneumonia.
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29

Judy, Carter E., M. Keith Chaffin, and Noah D. Cohen. "Empyema of the guttural pouch (auditory tube diverticulum) in horses: 91 cases (1977–1997)." Journal of the American Veterinary Medical Association 215, no. 11 (December 1, 1999): 1666–70. http://dx.doi.org/10.2460/javma.1999.215.11.1666.

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Objective To identify features of guttural pouch (auditory tube diverticulum) empyema in horses and compare findings of uncomplicated guttural pouch empyema with guttural pouch empyema complicated by chondroids. Design Retrospective study. Animals 91 horses with guttural pouch empyema. Procedure Medical records of horses with guttural pouch empyema were reviewed. Results The most common owner complaint and abnormal finding was persistent nasal discharge. Chondroids were detected in 21% (19/91) of affected horses. Streptococcus equi was isolated from the guttural pouch in 14 of 44 horses; for Streptococcus spp, in vitro resistance to sulfadimethoxine and trimethoprim-sulfamethoxazole was detected. Retropharyngeal swelling and pharyngeal narrowing were significantly more prevalent in horses with chondroids, compared with horses with uncomplicated empyema. Ninety-three percent of affected horses were discharged from the hospital; at time of discharge, 66% had complete resolution of disease, 19% had improvement without resolution, and 15% did not have improvement. Conclusions and Clinical Relevance Horses with persistent nasal discharge should be examined endoscopically for guttural pouch empyema. Treatment with lavage offers a good prognosis for resolution of uncomplicated guttural pouch empyema. Aggressive treatment with lavage and endoscopic snare removal of chondroids offers a good prognosis and may make surgical intervention unnecessary. (J Am Vet Med Assoc 1999;215:1666–1670)
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30

Dunlap, Daniel G., Roy Semaan, and David Feller-Kopman. "Empyema editorial." Journal of Thoracic Disease 10, S33 (November 2018): S3911—S3913. http://dx.doi.org/10.21037/jtd.2018.08.135.

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31

Goldstraw, Peter. "Postpneumonectomy Empyema." Journal of the Royal Society of Medicine 86, no. 10 (October 1993): 559–60. http://dx.doi.org/10.1177/014107689308601001.

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32

Ahmed, Ala Eldin H., and Tariq E. Yacoub. "Empyema Thoracis." Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 4 (January 2010): CCRPM.S5066. http://dx.doi.org/10.4137/ccrpm.s5066.

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Epmyema thoracis is associated with high mortality ranging between 6% to 24%. The incidence of empyema is increasing in both children and adults; the cause of this surge is unknown. Most cases of empyema complicate community- or hospital-acquired pneumonia but a proportion results from iatrogenic causes or develops without pneumonia. Parapneumonic effusions (PPE) develop in about one half of the patients hospitalized with pneumonia and their presence cause a four-fold increase in mortality. Three stages in the natural course of empyema have long been described: the exudative, fibrinopurulent, and organizing phases. Clinically, PPE are classified as simple PPE, complicated PPE, and frank empyema. Simple PPE are transudates with a pH > 7.20 whereas complicated PPE are exudates with glucose level <2.2 mmol/l and pH < 7.20. Two guidelines statements on the management of PPE in adults have been published by the American College of Chest Physicians (ACCP) and the British Thoracic Society (BTS). Although they differ in their approach on how to manage PPE, they agree on drainage of the pleural space in complicated PPE and frank empyema. They also recommend the use of intrapleural fibrinolysis and surgical intervention in those who do not show improvement, but the level of evidence for the use of intrapleural fibrinolysis is not high highlighting the need for more research in this area. A recently published large randomized trial has shown no survival advantage with the use of intrapleural streptokinase in patients with pleural infection. However, streptokinase enhances drainage of infected pleural fluid and may still be used in patients with large collection of infected pleural fluid causing breathlessness or ventilatory failure. There is emerging evidence that the combination of intrapleural tPA/DNase is significantly superior to tPA or DNase alone, or placebo in improving pleural fluid drainage in patients with pleural space infection. A guideline statement on the management of PPE in children has been published by the BTS. It recommends the use of antibiotics in all patients with PPE in addition to either video-assisted thoracoscopic surgery (VATS) or tube thoracostomy and intrapleural fibrinolysis. Prospective randomized trials have shown that intrapleural fibrinolysis is as effective as VATS for the treatment of childhood empyema and is a more economic treatment and therefore, should be the primary treatment of choice.
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33

Gemelli, N. A., N. M. Ciarrocchi, and E. San Roman. "Meningeal empyema." Medicina Intensiva (English Edition) 46, no. 3 (March 2022): 176. http://dx.doi.org/10.1016/j.medine.2019.11.010.

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34

Wheeler, Nicole, and Riyad Karmy-Jones. "Parapneumonic Empyema." Current Respiratory Medicine Reviews 8, no. 4 (July 1, 2012): 297–303. http://dx.doi.org/10.2174/157339812802652189.

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35

PLAYFOR, S. D., R. J. STEWART, C. M. SMITH, and A. R. SMYTH. "Childhood empyema." Thorax 54, no. 1 (January 1, 1999): 91. http://dx.doi.org/10.1136/thx.54.1.91c.

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36

Bryant, R. E., and C. J. Salmon. "Pleural Empyema." Clinical Infectious Diseases 22, no. 5 (May 1, 1996): 747–64. http://dx.doi.org/10.1093/clinids/22.5.747.

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37

Jaffe, A. "Thoracic empyema." Archives of Disease in Childhood 88, no. 10 (October 1, 2003): 839–41. http://dx.doi.org/10.1136/adc.88.10.839.

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38

Campbell, James D., and James P. Nataro. "PLEURAL EMPYEMA." Pediatric Infectious Disease Journal 18, no. 8 (August 1999): 725–26. http://dx.doi.org/10.1097/00006454-199908000-00015.

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39

Bockova, Jana, and Daniele Rigamonti. "INTRACRANIAL EMPYEMA." Pediatric Infectious Disease Journal 19, no. 8 (August 2000): 735–37. http://dx.doi.org/10.1097/00006454-200008000-00012.

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40

Jutley, RS, and DA Waller. "Empyema thoracis." Surgery (Oxford) 23, no. 11 (November 2005): 398–400. http://dx.doi.org/10.1383/surg.2005.23.11.398.

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41

Nelson, John D. "Pleural empyema." Pediatric Infectious Disease Journal 4, no. 3 (May 1985): S33. http://dx.doi.org/10.1097/00006454-198505010-00009.

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42

Ashbaugh, David G. "Empyema Thoracis." Chest 99, no. 5 (May 1991): 1162–65. http://dx.doi.org/10.1378/chest.99.5.1162.

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43

Kellie, Scott P., Fidaa Shaib, Derek Forster, and Jinesh P. Mehta. "Empyema Necessitatis." Chest 138, no. 4 (October 2010): 39A. http://dx.doi.org/10.1378/chest.9958.

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44

Abbas, Abbas El-Sayed, and Claude Deschamps. "Postpneumonectomy empyema." Current Opinion in Pulmonary Medicine 8, no. 4 (July 2002): 327–33. http://dx.doi.org/10.1097/00063198-200207000-00015.

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45

Choe, Du Hwan, Jeong Hoon Lee, Byung Hee Lee, Kie Hwan Kim, Soo Yil Chin, and Jae Ill Zo. "Postpneumonectomy empyema." Clinical Imaging 25, no. 1 (January 2001): 28–31. http://dx.doi.org/10.1016/s0899-7071(01)00237-6.

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46

Rizvi, Syed Imran A., and David A. Waller. "Empyema thoracis." Surgery (Oxford) 29, no. 5 (May 2011): 217–20. http://dx.doi.org/10.1016/j.mpsur.2011.02.009.

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47

Tenconi, Sara, and David A. Waller. "Empyema thoracis." Surgery (Oxford) 32, no. 5 (May 2014): 236–41. http://dx.doi.org/10.1016/j.mpsur.2014.02.012.

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48

McCormack, David J., and Jonathan R. Anderson. "Empyema thoracis." Surgery (Oxford) 35, no. 5 (May 2017): 243–46. http://dx.doi.org/10.1016/j.mpsur.2017.02.003.

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49

Pairolero, Peter C., Phillip G. Arnold, Victor F. Trastek, N. Bradly Meland, and Peter P. Kay. "Postpneumonectomy empyema." Journal of Thoracic and Cardiovascular Surgery 99, no. 6 (June 1990): 958–68. http://dx.doi.org/10.1016/s0022-5223(20)31451-3.

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&NA;. "SUBDURAL EMPYEMA." Pediatric Infectious Disease Journal 14, no. 8 (August 1995): 729. http://dx.doi.org/10.1097/00006454-199508000-00028.

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