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1

K, Ferguson Mark, ed. General thoracic surgery. Philadelphia: W.B. Saunders Company, 2002.

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2

Nnaabagereka, Sylvia Nagginda. Buganda empya: Obwakabaka obutonda eby'obugagga. Kampala: Kyakubibwa Limitless Opportunities Ltd., 2007.

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3

Niessen, Timothy. Pleural Effusions (Parapneumonic Process and Empyema). Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0024.

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Pleural effusions occur when an influx of fluid into the pleural space exceeds its removal. An exudative effusion, which results from leaky barriers, is often associated with infections. Parapneumonic effusions are exudative pleural effusions adjacent to pulmonary infections. Most parapneumonic effusions are sterile and resolve with treatment of the underlying pneumonia. They may, however, evolve through the exudative, fibrinopurulent, and organizing phases of empyema formation. Empyema occurs when frank pus occupies the pleural space and requires drainage. For parapneumonic process, antibiotic selection is similar to that for pneumonia and should target the underlying infectious organism according to culture and susceptibility results. Initial empiric therapy should take into account local antibiotic policies, resistance patterns, and should include anaerobic coverage. In some cases, after antibiotics and thoracentesis are initiated, surgical intervention may be necessary. Timely drainage of complicated parapneumonic effusions or empyema is critical.
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4

West, Tyler R., and Kelly J. Baldwin. Spinal and Intracranial Epidural Abscess, and Subdural Empyema. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0151.

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A spinal epidural abscess is an infection that resides in the epidural space of the spinal canal, and most commonly occurs from hematogenous seeding or direct extension from adjacent structures. Normal skin flora such as Staphylococcus and Streptococcus spp are the most common organisms to cause an epidural abscess, typically when host immunity is compromised or due to barrier disruption. The clinical presentation is heterogeneous, but often will progress over time to spinal cord compression. Intracranial epidural abscess and subdural empyema occur within the skull and are frequently spread via direct extension of infections from contiguous structures or as complications from neurosurgical procedures. Prompt diagnosis and treatment is essential for improving morbidity and mortality.
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5

A brief consideration of empyema of the accessory cavities of the nose. [S.l: s.n., 1985.

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6

A brief consideration of empyema of the accessory cavities of the nose. [S.l: s.n., 1985.

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7

Cerebral complications caused by extension from the accessory cavities of the nose. [S.l: s.n.], 1985.

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8

Grundy, Seamus. Pleural infection and malignancy. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0143.

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Pleural infection transitions from simple parapneumonic effusion, to complex parapneumonic effusion, to empyema. Primary empyema occurs without an underlying pneumonic process. Pleural infection commonly presents identically to pneumonia with dyspnoea, purulent sputum, and fevers. It may be associated with pleuritic chest pain. Empyema can cause systemic sepsis, leading to cardiovascular instability and multi-organ failure. A malignant pleural effusion arises when malignant cells infiltrate the pleura, resulting in increased production and decreased lymphatic drainage of pleural fluid. Malignant pleural effusions are either metastatic or primary mesothelioma. This chapter discusses pleural infection, malignant pleural effusion, and mesothelioma, focusing on etiology, symptoms, demographics, diagnosis, prognosis, and treatment.
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9

Török, M. Estée, Fiona J. Cooke, and Ed Moran. Respiratory, head, and neck infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0014.

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This chapter covers the common cold, pharyngitis, retropharyngeal abscess, quinsy (peritonsillar abscess), Lemierre’s disease, croup, epiglottitis, bacterial tracheitis, laryngitis, sinusitis, mastoiditis, otitis externa, otitis media, dental infections, lateral pharyngeal abscess, acute bronchitis, chronic bronchitis, bronchiolitis, community-acquired pneumonia, aspiration pneumonia, hospital-acquired pneumonia, ventilator-associated pneumonia, pulmonary infiltrates with eosinophilia, empyema, lung abscess, cystic fibrosis, bronchiectasis, and pulmonary tuberculosis.
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10

Török, M. Estée, Fiona J. Cooke, and Ed Moran. Neurological infections. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0019.

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This chapter covers both acute bacterial and viral, and chronic, meningitis, as well as tuberculous, cryptococcal, coccidioidal, and Histoplasma meningitis, describing meningeal symptoms (headache, neck stiffness, vomiting, photophobia) and cerebral dysfunction (confusion, coma). The chapter also covers neurocysticercosis (including parenchymal and extra-parenchymal cysts), encephalitis (an inflammatory process in the brain characterized by cerebral dysfunction), as well as brain abscess, cerebritis, subdural empyema, epidural abscess, and cerebrospinal fluid shunt infections.
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11

Todd, Claire, and Bruce McCormick. Thoracic surgery. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198719410.003.0015.

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This chapter discusses the anaesthetic management of thoracic surgery. It begins with general principles of thoracic surgery, including isolation of the lungs, one-lung ventilation, and providing analgesia for thoracic surgery. Surgical procedures covered include rigid bronchoscopy and bronchial stent insertion, mediastinoscopy, wedge resection, lobectomy, pneumonectomy, thoracoscopy and video-assisted thoracoscopic surgery, drainage of empyema and decortications, lung volume reduction surgery and bullectomy, repair of bronchopleural fistula, pleurectomy and pleurodesis, oesophagectomy, and surgical management of chest injuries.
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12

Treatment of Wounds of Lung and Pleura Based on a Study of the Mechanics and Physiology of the Thorax: Artificial Pheumothorax, Thoracentesis, Treatment of Empyema. Creative Media Partners, LLC, 2018.

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13

Morelli, Eugenio, and Frederick Carpenter Irving. The Treatment of Wounds of Lung and Pleura Based on a Study of the Mechanics and Physiology of the Thorax: Artificial Pheumothorax, Thoracentesis, Treatment of Empyema. Franklin Classics Trade Press, 2018.

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14

Grundy, Seamus. Pleural effusion. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0019.

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Pleural effusion is a common clinical problem which can present both to primary and secondary care. The process by which fluid accumulates can be divided into transudative or exudative. Transudative effusions occur in the presence of normal pleura and are caused by increased oncotic or hydrostatic pressures. Exudative effusions are associated with abnormal pleura and are caused either by increased pleural fluid production due to local inflammation or infiltration or by decreased fluid removal which is caused by obstruction of the lymphatic drainage system. Patients may be entirely asymptomatic or they may present with breathlessness, particularly if the effusion is large. Other symptoms include a cough and systemic symptoms such as weight loss, anorexia, and fever. Chest pain is suggestive of inflammation/infiltration of the parietal pleura and points towards malignancy or empyema. This chapter describes the assessment and diagnosis of the patient with pleural effusion.
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15

Chiumello, Davide, and Silvia Coppola. Management of pleural effusion and haemothorax. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0125.

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The main goal of management of pleural effusion is to provide symptomatic relief removing fluid from the pleural space. The options depend on type, stage, and underlying disease. The first diagnostic instrument is the chest radiography, while ultrasound can be very useful to guide thoracentesis. Pleural effusion can be a transudate or an exudate. Generally, a transudate is uncomplicated effusion treated by medical therapy, while an exudative effusion is considered complicated effusion and should be managed by drainage. Refractory non-malignant effusions can be transudative (congestive heart failure, cirrhosis, nephrosis) or exudative (pancreatitis, connective tissue disease, endocrine dysfunction), and the management options include repeated therapeutic thoracentesis, in-dwelling pleural catheter for intermittent external drainage, pleuroperitoneal shunts for internal drainage, or surgical pleurectomy. Parapneumonic pleural effusions can be classified as complicated when there is persistent bacterial invasion of the pleural space, uncomplicated and empyema with specific indications for pleural fluid drainage. Malignancy is the most common cause of exudative pleural effusions in patients aged >60 years and the decision to treat depends upon the presence of symptoms and the underlying tumour type. Options include in-dwelling pleural catheter drainage, pleurodesis, pleurectomy, and pleuroperitoneal shunt. Haemothorax needs to be differentiated from a haemorrhagic pleural effusion and, when suspected, the essential management is intercostal drainage. It achieves two objectives to drain the pleural space allowing expansion of the lung and to allow assessment of rates of blood loss to evaluate the need for emergency or urgent thoracotomy.
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16

Blasi, Francesco, and Paolo Tarsia. Pathophysiology and causes of haemoptysis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0126.

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The main goal of management of pleural effusion is to provide symptomatic relief removing fluid from pleural space and the options depend on type, stage and underlying disease. The first diagnostic instrument is the chest radiography while ultrasound can be very useful to guide thoracentesis. Pleural effusion can be a transudate or an exudate. Generally a transudate is uncomplicated effusion treated by medical therapy, while an exudative effusion is considered complicated effusion and should be managed by drainage. Refractory non-malignant effusions can be transudative (congestive heart failure, cirrhosis, nephrosis) or exudative (pancreatitis, connective tissue disease, endocrine dysfunction), and the management options include repeated therapeutic thoracentesis, indwelling pleural catheter for intermittent external drainage, pleuroperitoneal shunts for internal drainage, or surgical pleurectomy. Parapneumonic pleural effusions can be divided in complicated when there is persistent bacterial invasion of the pleural space, uncomplicated and empyema with specific indications for pleural fluid drainage. Malignancy is the most common cause of exudative pleural effusions in patients aged >60 years and the decision to treat depends upon the presence of symptoms and the underlying tumour type. Options include indwelling pleural catheter drainage, pleurodesis, pleurectomy and pleuroperitoneal shunt. Hemothorax needs to be differentiated from a haemorrhagic pleural effusion and when is suspected the essential management is the intercostal drainage. It achieves two objectives to drain the pleural space allowing expansion of the lung and to allow assessment of rates of blood loss to evaluate the need for emergency or urgent thoracotomy.
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17

Bröer, Karl-Friedrich. Zur Problematik spinaler Abszesse oder Empyeme in der Neurochirurgie. 1989.

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