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Journal articles on the topic 'Employment profile'
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1
Mallett, Ted. "A PROFILE OF SELF-EMPLOYMENT EARNINGS." Journal of Small Business & Entrepreneurship 8, no. 3 (January 1991): 15–20. http://dx.doi.org/10.1080/08276331.1991.10600374.
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Montero-Moraga, Jose M., Fernando G. Benavides, and Maria Lopez-Ruiz. "Association Between Informal Employment and Health Status and the Role of the Working Conditions in Spain." International Journal of Health Services 50, no. 2 (January 5, 2020): 199–208. http://dx.doi.org/10.1177/0020731419898330.
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Informal employment is an employment condition in which workers are not protected by labor regulations. It has been associated with poor health status in middle- and low-income countries, but it is still a neglected issue in high-income countries. Our aim was to estimate the association between health status and employment profiles in Spain, attending to the role of workplace risk factors. We conducted a cross-sectional study of 8,060 workers from the Seventh Spanish Working Conditions Survey (2011). We defined 4 employment profiles and estimated the associations between them and poor self-perceived health using Poisson regression models. All analyses were stratified by sex. The prevalence of the informal profile was 4% for women and 1.5% for men. Differences in self-perceived health status among employment profiles were negligible. Only women engaged in informal employment had poorer self-perceived health than those in the reference profile. This difference disappeared after adjusting models for psychosocial risk factors. In conclusion, we did not find differences in self-perceived health status between employment profiles, except for women in informal employment. Efforts should be made to improve the psychosocial risk factors in women in informal employment.
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Борисова, Алена, and Alena Borisova. "INSTRUMENTS OF DIAGNOSTICS OF PROFILE EMPLOYMENT OF GRADUATES: LIMITATIONS AND RESULTS." Bulletin of Kemerovo State University. Series: Political, Sociological and Economic sciences 2016, no. 1 (June 25, 2016): 10–16. http://dx.doi.org/10.21603/2500-3372-2016-1-10-16.
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The paper considers the way of theoretical and methodological research of solving the task of graduates’ professional employment, also it describes the consequences of putting in practice the standards of assistance of professional employment for graduates. Prospects and restraints of using the diagnostic methods in the graduates’ streaming are analyzed. The necessity of enlarging graduation employment’s types is reasoned on the base of searching types introduction. New method of defining the types of graduates’ employment is proved. The main criterion of this method’s efficiency is “closeness to the sphere of education”. According to the materials of regional researches, the author has grounds to suggest that the method can be made the part of the university’s informational system. The results show the influence of the externals of the educational sphere (type of specialization, qualification level, region, type of educational institution, graduation year and gender) on the professional employment of higher school graduates.
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Stock, L. "Hispanic Americans: A Brief Profile." Journal of Visual Impairment & Blindness 81, no. 6 (June 1987): 262–63. http://dx.doi.org/10.1177/0145482x8708100608.
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The latest population statistics show the Hispanic population in the US to be fast-growing, young and very diverse in nature. While the Hispanic group lags behind the general population in average education and employment rates, many gains have been made in the past decade. The growing numbers and attainments of Hispanics will mean an increased demand for better education, employment and training programs, housing and family services.
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Sander, Tom, Phoey Lee Teh, and Biruta Sloka. "Your social network profile reveals you." International Journal of Web Information Systems 13, no. 1 (April 18, 2017): 14–24. http://dx.doi.org/10.1108/ijwis-06-2016-0029.
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Purpose This study aims to evaluate the fears of individuals on their profiles’ sharing in social network sites (SNSs), regarding its advantages and disadvantages. The researched issues are related with the employment seeking process. The concern of this study is the deviation observation between the fears acquired by the business and private social media members. Design/methodology/approach This study included an online survey with 236 respondents and calculated indicators of central tendency or location parameter, correlation coefficients and performed analysis of variance. Findings The result indicated and revealed the hidden danger and opportunities among social network members’ profile. This result addressed the need to consider the issue of user’s fears in reengineering the practical use of SNSs by organisations. Research limitations/implications Interesting for further research would be to transfer this research from the employment seeking process in other research fields to generalise the results more accurately. Originality/value The contribution to the research field is to compare different SNSs and to explain the reasons to use SNS profiles to support organisations by their decisions for a valuable strategy. This study provides an insight in use and behaviour of SNS members that support researchers to understand the behaviour of SNS members regarding their profile under consideration of the employment seeking process.
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Gunashekhar, H., M. Sreenivasulu, P. Prashanth, and G. E. Ch Vidya sagar. "Vulnerable Employment of Rural Youth – A Profile Analysis." International Journal of Current Microbiology and Applied Sciences 9, no. 8 (August 8, 2020): 1520–27. http://dx.doi.org/10.20546/ijcmas.2020.908.176.
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Sobral, Filipa, Maria José Chambel, and Filipa Castanheira. "Managing motivation in the contact center: The employment relationship of outsourcing and temporary agency workers." Economic and Industrial Democracy 40, no. 2 (June 6, 2016): 357–81. http://dx.doi.org/10.1177/0143831x16648386.
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Grounded in self-determination theory (SDT), this research builds a motivation profile typology of contingent workers in the contact center industry, compares outsourcer (OW) and temporary agency workers’ (TAW) profiles, and differentiates their human resources practices (HRP) perceptions and affective commitment. The hypotheses were tested in a sample of 2078 Portuguese contingent workers, through several statistical procedures, including latent profile analysis. Six profiles were identified. As expected, OW were mostly in the more intrinsic profiles, whereas TAW were in the more extrinsic ones. However, the contingent employment format did not moderate the relationship between motivation, HRP perceptions, and affective commitment.
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Marinas, A., E. Elices, A. Gil-Nagel, J. Salas-Puig, J. C. Sánchez, M. Carreño, V. Villanueva, J. Rosendo, J. Porcel, and J. M. Serratosa. "Socio-occupational and employment profile of patients with epilepsy." Epilepsy & Behavior 21, no. 3 (July 2011): 223–27. http://dx.doi.org/10.1016/j.yebeh.2011.01.025.
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Cioci, Brian W., Robert Boyce, Michael OʼConnor, Ed Boone, Albert Lee, Josh Bolton, David Mills, and Robert Boyce. "Profile of Weight Gained after Employment in Sedentary Occupation." Medicine & Science in Sports & Exercise 38, Supplement (May 2006): S455. http://dx.doi.org/10.1249/00005768-200605001-02787.
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Tanaka, Yasuhide. "Employment tenure, job expectancy, and earnings profile in Japan." Applied Economics 33, no. 3 (February 2001): 365–74. http://dx.doi.org/10.1080/00036840122873.
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Šařec, P., and O. Šařec. "Employment characteristics of tine cultivators at deeper soil loosening." Research in Agricultural Engineering 61, No. 2 (June 2, 2016): 80–86. http://dx.doi.org/10.17221/72/2013-rae.
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The work quality of selected tine cultivators that are suitable equally for deeper soil cultivation has been evaluated. The following implements were tested in a stubble field: Köckerling Vario 570, Simba Solo 450, Horsch Terrano 5 FX, Strom Finisher Mega 8000, Farmet Turbulent 450, Kverneland CLC 430, Väderstad TopDown 400. The cultivator evaluation criteria were the following: quantity of plant residues left on the soil surface, size distribution of clods, transverse elevation profile of the soil surface, elevation profile of the furrow bottom, cultivation depth, unit fuel consumption, travel reduction ratio, work-rate, and unit draft of a cultivator. All of the cultivators were equipped mainly with tine tools, followed further on by disc tools and either by levelling or by crumbling tools. Plant residues were well worked into the soil by Väderstad and Farmet cultivators. Horsch, Kverneland and Väderstad cultivators showed good crumbling effect. The highest work speed was reached by tractors with Strom and Horsch implements.
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Winking, Deborah L., John S. Trach, Frank R. Rusch, and Jeffrey Tines. "Profile of Illinois Supported Employment Specialists: An Analysis of Educational Background, Experience, and Related Employment Variables." Journal of the Association for Persons with Severe Handicaps 14, no. 4 (December 1989): 278–82. http://dx.doi.org/10.1177/154079698901400406.
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Coordinators of Illinois supported employment programs were surveyed for information regarding the demographics and reasons for job turnover of employment specialists. In addition, the employment specialist position was compared with that of direct service personnel in local rehabilitation agencies in terms of salary, benefits, and turnover. Survey results showed that although 58% of the programs responding required employment specialist applicants to hold a bachelor's degree, only 34% of those employment specialists actually hired held a bachelor's degree in a related field and an additional 10% held a degree in an unrelated field. Approximately two individuals were hired for every available employment specialist position in the Illinois supported employment program, with salary identified as the primary reason for the turnover. Although the nature of the direct service role fulfilled by the employment specialist in supported employment differs greatly from that of traditional direct service personnel within the local rehabilitation agency (e.g., workshop floor supervisors, day activity trainers), 55% of the programs responding stated that the salary levels for the two groups were comparable.
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Vanroelen, Christophe. "Employment Quality: An Overlooked Determinant of Workers’ Health and Well-being?" Annals of Work Exposures and Health 63, no. 6 (June 21, 2019): 619–23. http://dx.doi.org/10.1093/annweh/wxz049.
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Abstract In the past four decades, high-income countries have seen a thorough socio-economic restructuring with important implications for the jobs of many workers, including health- and safety-related aspects. Much attention has been paid to psychosocial risks related to intrinsic features of contemporary work tasks, while the occupational health and safety consequences of ‘new’ conditions and relations of employment have remained neglected. This relative neglect is unjustified given the disrupting nature of many contemporary forms of employment. In this commentary, I introduce the concept of ‘employment quality’ as a novel approach towards measuring employment-related OHS risks. Employment quality involves a ‘typological approach’ towards employment arrangements, identifying five employment types in European labour markets, showing a distinct profile in terms of health-related employment characteristics. Moreover, these types align with segmented labour market theory, have a clear socio-economic profile, and show strong associations with workers’ self-reported health.
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López, Bernardo Gargallo, and Cruz Pérez Pérez. "Transversal Competences for Employment and Profile of Excellent University Students." Procedia - Social and Behavioral Sciences 139 (August 2014): 305–13. http://dx.doi.org/10.1016/j.sbspro.2014.08.004.
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Mangan, David. "Does an online professional profile violate an employer’s confidentiality?" European Labour Law Journal 12, no. 1 (March 2021): 102–4. http://dx.doi.org/10.1177/2031952521998813.
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Mahmuda, Dede. "Marginal Part-Time Employment in Indonesian Labor Market: Profile and Determinant." Jurnal Economia 16, no. 2 (October 30, 2020): 236–44. http://dx.doi.org/10.21831/economia.v16i2.30818.
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Abstract: The increase of marginal part-time employment has been found in developed countries, as well as in developing countries. This form of non-standard employment has very short work hours (less than 15 hours/week) and no guarantee of stable employment. In Indonesia, the share of part-time worker amongst working population increased from 15.4 percent in 2009 to 22.1 percent in 2018. Unfortunately, few studies discuss about marginal part-time employment. Using binary logistic regression, this study aims to identify marginal part-time workers based on their socio-demographic characteristic. The result indicates that female (OR: 1.81; 95% CI: 1.75-1.87), living in rural area (OR: 1.12; 95% CI: 1.08-1.16), and less educated are more likely to be marginal part-timer. Therefore, it is recommended for policymakers to ensure the labor regulation adequately protect the rights of part-time worker, so that the workers condition can be improved since they are most vulnerable group in the globalized economy.Keywords: non-standard employment, labor market, part-time, Indonesia Pekerja Paruh Waktu Marjinal Pada Pasar Tenaga Kerja Indonesia: Profil dan DeterminanAbstrak: Peningkatan pekerja paruh waktu marjinal telah teramati pada negara-negara maju dan juga negara berkembang. Salah satu bentuk pekerjaan non-standar ini memiliki jam kerja yang sangat pendek (kurang dari 15 jam seminggu) dan tidak adanya jaminan kestabilan pekerjaan. Di Indonesia, proporsi pekerja paruh waktu diantara penduduk bekerja meningkat dari 15,4 persen pada 2009 menjadi 22,1 persen pada 2018. Sayangnya, hanya sedikit studi yang membahas tentang pekerjaan paruh waktu marjinal. Dengan menggunakan regresi logistik biner, studi ini bertujuan untuk mengidentifikasi pekerja paruh waktu marjinal berdasarkan karakteristik sosio-demografinya. Hasil menunjukkan bahwa perempuan (OR: 1,81; 95% CI: 1,75-1,87), penduduk desa (OR: 1,12; 95% CI: 1,08-1,16), dan kurang berpendidikan berisiko lebih besar menjadi pekerja paruh waktu marjinal. Oleh karena itu, direkomendasikan bagi pembuat kebijakan untuk dapat memastikan peraturan ketenagakerjaan cukup untuk melindungi hak-hak pekerja paruh waktu khusus yang termarjinal agar kondisi pekerja dapat ditingkatkan karena mereka adalah kelompok paling rentan dalam ekonomi global.Kata kunci: pekerjaan non-standar, pasar tenaga kerja, paruh waktu, Indonesia
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Mak, Vivienne S. L., Alice Clark, Geoff March, and Andrew L. Gilbert. "The Australian pharmacist workforce: employment status, practice profile and job satisfaction." Australian Health Review 37, no. 1 (2013): 127. http://dx.doi.org/10.1071/ah12180.
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Objective. The aims were to determine Australian registered pharmacists’ current employment status, practice profile and professional satisfaction. Method. A questionnaire was mailed to all registered pharmacists (n = 7764) on the Pharmacy Boards of Victoria and South Australia’s registers; 19 were returned undeliverable. Quantitative data were entered and analysed using the Statistical Package for Social Sciences Version 17. Qualitative data were subjected to a thematic analysis. Results. 1627 (21%) pharmacists responded: 259 (16%) were registered as pharmacists but no longer worked in the pharmacy profession. A total of 1366 respondents reported still working as pharmacists. Of the 1366, 912 (67%) indicated that they spend most of their time in a clinical area; 233 (17%) spend most of their time in ‘non-clinical pharmacist work (i.e. dispensing as technical supply)’; 216 (16%) worked in other non-clinical roles and; 1053 (77%) were professionally satisfied. Conclusion. Measuring the pharmacist workforce based on registration data significantly overestimates the available clinical pharmacist workforce: 708 (44%) respondents were no longer working in the profession, were not mainly involved in clinical practice or were working in non-clinical roles. A significant re-professionalisation program is needed if pharmacists’ unique knowledge and skills are to contribute to better healthcare delivery. What is known about the topic? A well trained and sufficient workforce is an essential requirement if the objectives of Australia’s healthcare reform agenda are to be met. For the pharmacy profession, a change in practice profile of pharmacists from a product supply focus to a patient care focus is also required. Recent workforce studies have used pharmacist registration data to model the supply of pharmacists. What does this paper add? This paper reports on a survey of registered pharmacists to more closely examine the available pharmacist workforce. The insights into the current employment status and practice profile of pharmacists provide an understanding of the available clinical pharmacist workforce. What are the implications for practitioners? Previous workforce modelling may seriously overestimate the ‘available’ pharmacist workforce to meet the needs of the community as the health reform agenda rolls out. Strategies are needed to retain pharmacists within the pharmacy profession, and to attract and retain pharmacists in clinical roles.
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Hoekema, David A. "Special Report: Profile of APA Membership, Employment Patterns, and Doctoral Degrees." Proceedings and Addresses of the American Philosophical Association 62, no. 5 (June 1989): 839. http://dx.doi.org/10.2307/3130347.
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Garzón-Duque, María Osley, María Doris Cardona-Arango, Fabio León Rodríguez-Ospina, and Angela María Egura-Cardona. "Informality and employment vulnerability: application in sellers with subsistence work." Revista de Saúde Pública 51 (October 11, 2017): 89. http://dx.doi.org/10.11606/s1518-8787.2017051006864.
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OBJECTIVE: To describe the origin, evolution, and application of the concept of employment vulnerability in workers who subsist on street sales. METHODS: We have carried out an analysis of the literature in database in Spanish, Portuguese, and English, without restriction by country. This is a review of the gray literature of government reports, articles, and documents from Latin America and the Caribbean. We have analyzed information on the informal economy, social-employment vulnerability, and subsistence workers. RESULTS AND CONCLUSIONS: The concept of informal economy is dispersed and suggested as synonymous with employment vulnerability. As a polysemic term, it generates confusion and difficulty in identifying defined profiles of employment vulnerability in informal subsistence workers, who sell their products on the streets and sidewalks of cities. The lack of a clear concept and profile of employment vulnerability for this type of workers generates a restriction on defined actions to reduce employment vulnerability. The profiles could facilitate access to the acquisition of assets that support their structure of opportunities, facilitating and mediating in the passage from vulnerability to social mobility with opportunities. We propose as a concept of employment vulnerability for subsistence workers in the informal sector, the condition of those who must work by day to eat at night, who have little or no ownership of assets, and who have a minimum structure of opportunities to prevent, face, and resist the critical situations that occur daily, putting at risk their subsistence and that of the persons who are their responsibility, thus making the connection between social and employment vulnerability
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Magun, Sunder. "The Rise of Service Employment in the Canadian Economy." Relations industrielles 37, no. 3 (April 12, 2005): 528–56. http://dx.doi.org/10.7202/029278ar.
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This paper analyzes the trends in employment shares by industry and presents an employment profile of the service-producing and goods-producing sectors and examines some of the reasons for the shift to service jobs.
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Wang, Zhixing, Wayne Fritschle, Richard Bennington, Bettina Burnworth, Angela Bennington, Collette Wentzel, Stephanie Verkamp, et al. "MYD88 L265P Mutation Detection: Analysis of Flow Cytometry Sorted Plasma and Lymphoid Cell Clones Improves Sensitivity and Specificity for WM/LPL Diagnosis." Blood 124, no. 21 (December 6, 2014): 1645. http://dx.doi.org/10.1182/blood.v124.21.1645.1645.
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Abstract Background: Waldenström's macroglobulinemia (WM) and lymphoplasmacytic lymphoma (LPL) are lymphoproliferative disorders with bone marrow infiltration by clonal lymphoplasmacytic cells (Treon et al., 2003, 2005). The somatic point mutation L265P in the myeloid differentiation primary response gene 88 (MYD88) has been reported in more than 90% of WM patients (Treon et al., 2012). Therefore MYD88 mutation analysis has been implemented in clinical practice to support the diagnosis of LPL/WM. After the implementation of MYD88 L265P assays with increased detection sensitivity, a substantial portion of patients with IgM monoclonal gammopathy of undetermined significance (IgM-MGUS) was also reported MYD88 L265P positive. Splenic marginal zone lymphoma (SMZL), B-cell chronic lymphoproliferative disorders (B-CLPD) and diffused large B-cell lymphoma (DLBCL) have been found positive with much lower incidence rates (Varettoni et al., 2013; Xu et al., 2013). Hence the remaining need to differentiate WM/LPL from other lymphoproliferative disorders with co-occurring plasma cells with high confidence. Patients and Methods: In this study, flow cytometric cell sorting was utilized to isolate clonal plasma and B lymphoid cell fractions as previously described (Zehentner et al., 2011). 69 patient specimen fractions with a clinical history of WM /LPL, multiple myeloma, CLL and lymphoma were analyzed for MYD88 L265P mutation using Sanger sequencing. Furthermore, the Biomed-2 primer sets for the immunoglobulin heavy (IgH) and/or the immunoglobulin kappa light chain region (IgK) were used to compare B cell clonality profiles in the lymphoid versus plasma cell compartments. Results: MYD88 L265P mutation was detected in all specimens with confirmed Waldenström's macroglobulinemia (17/17, 100%). Of these 16/17 (94%) revealed MYD88 L265P as well as identical monoclonality profile by gene rearrangement analysis in both the plasma and the B lymphoid cell collections. In 47% (8/17), the mutation was only detected in the plasma and B cell fractions, but not in the whole bone marrow specimens. 21 patient specimens with a known clinical history of LPL and co-occurring clonal plasma cells were tested. 9 of 21 (43%) were categorized with identical B cell clonality profile when comparing plasma and B lymphoid cells; whereas 12 (57%) had unrelated clonality profiles. 7 of the 9 (78%) specimens in the identical clonality group tested positive for MYD88 L265P in both the plasma and B lymphoid clone. None of the unrelated clonality group specimens carried the mutation in both cell fractions; for 7/12 (58%) MYD88 L265P was found in either the plasma (2) or the B-cell fraction (5) whereas 5/12 (42%) tested negative. 11 bone marrow aspirate specimen with known presence of lymphoma (including splenic marginal zone (SMZL), mantle cell and marginal zone) were analyzed. 10/11 (90%) tested negative for MYD88 L265P, with the exception of one SMZL specimen. Furthermore, 12 known myeloma, 5 CLL and 3 healthy donor specimens were analyzed, all tested negative. Conclusions: In this study, we developed and tested a novel approach to assess MYD88 L265P mutation status in order to assist WM/LPL diagnosis. Flow cytometric cell sorting for clonal plasma and B cell populations was combined with molecular analysis. Subsequently, MYD88 L265P mutation as well as B-cell clonality profile was compared in both cell fractions. Our study postulates a significant improvement in sensitivity and most importantly specificity when applying MYD88 L265P mutation status in combination with cell sorting for WM/LPL diagnostic decisions. 47% WM patients (8/17) and 44% LPL patients (4/9) were positive for the MYD88 mutation exclusively in both flow cytometry sorted cell fractions but not in whole bone marrow specimens. 94% (16/17) WM as well as 78% (7/9) LPL specimens with identical plasma and B-cell clonality profile revealed the presence of the MYD88 L265P mutation in both the plasma cell and the B lymphoid cell clones. Whereas LPL specimens with unrelated clonality profile of the plasma and lymphoid cell fractions as well as other control specimens (lymphoma, myeloma, CLL and healthy) either tested negative or positive only in one of the sorted cell fractions. We therefore conclude that confirming the presence of MYD88 L265P in both B-lymphoid and plasma cell fraction is an important prerequisite to distinguish LPL/WM from related disorders with high confidence. Disclosures Wang: HematoLogics Inc.: Employment. Fritschle:HematoLogics Inc.: Employment. Bennington:HematoLogics Inc.: Employment. Burnworth:HematoLogics Inc.: Employment. Bennington:HematoLogics Inc.: Employment. Wentzel:HematoLogics Inc.: Employment. Verkamp:HematoLogics Inc.: Employment. Nguyen:HematoLogics Inc.: Employment. Ghirardelli:HematoLogics Inc.: Employment. Broderson:HematoLogics Inc.: Employment. Wells:HematoLogics Inc.: Employment, Equity Ownership. Loken:HematoLogics Inc.: Employment, Equity Ownership. Zehentner:HematoLogics Inc.: Employment, Equity Ownership.
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Stepick, Alex, and Alejandro Portes. "Flight into Despair: A Profile of Recent Haitian Refugees in South Florida." International Migration Review 20, no. 2 (June 1986): 329–50. http://dx.doi.org/10.1177/019791838602000212.
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Based on a random sample survey of recently arrived Haitians, participant observation, and intensive interviewing, this article examines the following areas: a) individual background characteristics of Haitian immigrants; b) their arrival and early resettlement experiences; c) their education, knowledge of English and information about the United States; d) current employment status and occupation; e) income and use of public assistance; f) predictors of employment, occupation, and income; and g) beliefs and orientations. These results are presented after discussion of the methodology of the study and the context of out-migration from Haiti.
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Jura, Oleksandr, Nataliia Ridei, Katerina Shovsh, and Al`ona Biletska. "THE ROLE OF CONTINUING EDUCATION IN THE FORMATION OF THE ACADEMIC CULTURE OF TEACHING STAFF IN HIGHER EDUCATIONAL INSTITUTIONS." Educational Discourse: collection of scientific papers, no. 19(1) (February 3, 2020): 7–22. http://dx.doi.org/10.33930/ed.2019.5007.19(1)-1.
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The thesaurus of academic culture is analyzed, the analysis of value-based social educational and scientific orientations of social categories of professionally interested teachers in prolonged employment throughout life is carried out; a semantic systematic analysis of the structure and content of cultures of the conditioned relationships between a person and society, future teachers and poly profile professional environments of their implementation and employment is carried out; a semantic systematic analysis of the structure and content of cultures of the conditioned relationships between a person and society, future teachers and poly profile professional environments of their implementation and employment is carried out; the role of ecological culture in ensuring the sustainability of social development of the noospherological paradigm of scientific knowledge is substantiated.
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Bairwa, Shoji Lal, Saket Kushwaha, Chandra Sen, and Rakesh Singh. "Analysis of socio economic profile of trained agri graduates under agriclinics and agribusiness centres (ACABC‟s) scheme in Rajasthan." International Journal of Agricultural Invention 2, no. 01 (June 30, 2017): 96–102. http://dx.doi.org/10.46492/ijai/2017.2.1.22.
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Agriclinics and agribusiness centres (ACABC‟s) scheme is a subsidy based credit linked scheme launched by government of India on 9th April, 2002 for the strengthen technology transfer, public extension system and employment generation in rural areas. The present study was conducted in Rajasthan state during 2011 to 2015 and based on the primary data collected through field survey by pre tested questionnaires from 150 sample agrigraduates. The objective of study was to analyse the profile of agrigraduates on the basis of socio economic characteristics. The socio-economic profile were covered under broad categories such as socioeconomic profile of the trained agripreneurs, status of agriventure taken, status of loans obtained and approached, reasons for refusal of loan application, reasons for willingness and not willingness to take up agriventures under the scheme. The appropriate statistical techniques such as frequencies, scores and percentages were used to analyse the socio economic profile of agrigraduates under agriclinics and agribusiness centres scheme. The study results and previous literature are indicated that the most important factors influencing establishment of agribusiness units are attitude towards self-employment, better livelihood opportunities, entrepreneurial ability, motivation from successful entrepreneurs and self-confidence. Gender-related variations were also significant with regard to attitude towards self-employment, decision-making ability and information seeking behaviour. Thus, there is need to change in the attitude of agrigraduates towards self-employment, develop entrepreneurial ability and enhance self-confidence of the trainees through the training programmes.
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Gonçalves, Nelson D., Ângela M. Ribau, Olga S. Carneiro, and João M. Nóbrega. "Computer Aided Design of Extrusion Dies for Complex Geometry Profiles." Materials Science Forum 730-732 (November 2012): 495–500. http://dx.doi.org/10.4028/www.scientific.net/msf.730-732.495.
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The inherent design freedom promoted by the employment of thermoplastic profiles is one of the major reasons for their attractiveness. Theoretically, thermoplastic profiles can be produced with any cross section suited for a specific application. The design of the corresponding extrusion dies usually employ a methodology based on experimental trial-and-error approaches, being highly dependent on the experience of the designer and highly demanding in terms of resources. These difficulties are obviously more evident when the plastic profile has a complex geometry. This research team is involved since the mid-nineties on the development of computational tools to aid the design of thermoplastic profile extrusion dies. Initially, the numerical code employed was based on structured meshes that limited its use to simple geometries. In this work, a numerical modelling code developed to work with unstructured meshes is described and employed in a case study involving the design of a extrusion die for the production of complex cross section profile. The results obtained show that the developed code can be a useful tool to aid the design of complex profile extrusion dies.
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Kalian, N., H. Zhao, and J. Qiao. "Investigation of transition between spark ignition and controlled auto-ignition combustion in a V6 direct-injection engine with cam profile switching." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 222, no. 10 (October 1, 2008): 1911–26. http://dx.doi.org/10.1243/09544070jauto846.
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Controlled auto-ignition (CAI) combustion, also known as homogeneous charge compression ignition (HCCI), can be achieved by trapping residuals with early exhaust valve closure in a direct-fuel-injection in-cylinder four-stroke gasoline engine (through the employment of low-lift cam profiles). Because the operating region is limited to low-load and midload operation for CAI combustion with a low-lift cam profile, it is important to be able to operate spark ignition (SI) combustion at high loads with a normal cam profile. A 3.0l prototype engine was modified to achieve CAI combustion, using a cam profile switching mechanism that has the capability to switch between high- and low-lift cam profiles. A strategy was used where a high-lift profile could be used for SI combustion and a low-lift profile was used for CAI combustion. Initial analysis showed that for a transition from SI to CAI combustion, misfire occurred in the first CAI transitional cycle. Subsequent experiments showed that the throttle opening position and switching time could be controlled to avoid misfire. Further work investigated transitions at different loads and from CAI to SI combustion.
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Khuntia, Janmejoy. "Profile of employment of social groups in the MSMEs in India as per Fourth MSME Census." Journal of Business Management and Information Systems 4, no. 2 (December 31, 2017): 10–16. http://dx.doi.org/10.48001/jbmis.2017.0402002.
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Micro, small and medium enterprises (MSMEs) sector holds a very important position in the Indian economy in terms contribution to the GDP as well as generating gainful employment. India being a heterogenous society, one important aspect of employment is the issue of its distribution among the various social groups, such as the scheduled caste (SCs), scheduled tribe (STs), other backward classes (OBCs) and others comprising of the general caste category. Study of distribution of employment among these social groups enables us to analyze the economic engagement of the work force in one of the industrial sectors of the country. It is also helpful in studying social development of India
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Dye, Christopher K. "Descriptive Profile and Survey of Alternatively Certified Texas Music Educators." Journal of Music Teacher Education 27, no. 3 (September 14, 2017): 24–37. http://dx.doi.org/10.1177/1057083717731769.
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The purpose of the study was to examine the features of Texas’s Alternative Route to Certification (ARC) programs in music education, the demographics and prior experiences of program completers, and the employment of ARC completers in K–12 public schools. Data were collected from the State Board of Educator Certification about demographics and employment information for all individuals who completed ARC programs in music education between 2002 and 2012 ( N = 1,200), and individuals from that population were surveyed concerning their experiences ( n = 214). Survey respondents completed programs that varied widely in duration, features, instructional modalities, and providing institutions. Music educator gender and ethnicity were significantly associated with the route used to pursue alternative certification. Relative to the distribution of music teaching positions across the state, ARC completers were disproportionately employed in large urban districts, charter school districts, and in districts with large proportions of economically disadvantaged students.
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Li-Tsang, Cecilia W. P., and Joanne W. M. Mok. "Survey on the Employment Profile of Occupational Therapy Graduates in Hong Kong." Hong Kong Journal of Occupational Therapy 16, no. 1 (2006): 1–8. http://dx.doi.org/10.1016/s1569-1861(09)70033-6.
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Salzberg, Charles L., Martin Agran, and Benjamin Lignugaris/Kraft. "Behaviors that contribute to entry-level employment a profile of five jobs." Applied Research in Mental Retardation 7, no. 3 (January 1986): 299–314. http://dx.doi.org/10.1016/s0270-3092(86)80003-0.
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Vardarlier, Pelin, and Rana Cakir. "A Study on Sustainable Innovation Profile of Turkey." International Journal of Research in Business and Social Science (2147-4478) 4, no. 4 (October 22, 2015): 24–35. http://dx.doi.org/10.20525/ijrbs.v4i4.16.
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Innovation is the only way of solution to achieve sustainable growth, social welfare and employment in a country. This study principally focuses on the relationship between growth and innovation in the light of information derived from a general literature review about definition, sources and risks of innovation, and measurement of innovation performance. Then, the contributions of innovative capability on economic growth and employment as well as innovation systems on a country basis have been discussed, and accordingly, actions to be taken, including a shift in paradigm, for a growth-innovation-national innovation system and its sustainability have been addressed. In addition, current innovation performance indicators of Turkey have been discussed in the light of a scope which is outlined in the initial sections of the study, and the change in such performance indicators between 1998 and 2009 has been examined. After analysis of the above mentioned criteria and comparisons against practices in developed countries and communities, suggestions have been made about the activities to be carried out in order to make Turkey’s current innovation system “sustainable”, to support and improve innovation. In the study, a research application has been conducted using the content analysis method on the “President’s Message” letters of 158 state and foundation universities that are located in Turkey and that have a website, and the importance accorded to innovation by the universities has been determined.
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An, Gang, Weiwei Sui, Tingyu Wang, Xiaoyan Qu, Xian Zhang, Junfang Yang, Yan Zhang, et al. "An Anti-Bcma CAR T-Cell Therapy (C-CAR088) Shows Promising Safety and Efficacy Profile in Relapsed or Refractory Multiple Myeloma." Blood 136, Supplement 1 (November 5, 2020): 29–30. http://dx.doi.org/10.1182/blood-2020-138734.
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Background: C-CAR088, an anti-BCMA CAR T-cell therapy is a novel 2nd generation 4-1BB chimeric antigen receptor T (CAR-T) cell therapy targeting BCMA which is specifically and highly expressed on multiple myeloma (MM) cells. C-CAR088 is manufactured in a serum-free, automated and digital, closed system. Initial, early clinical trial results in patients with R/R MM supported preclinical findings and showed promising efficacy and manageable safety profile (Yao, Blood (2019) 134 (Supplement_1): 50.) Methods: The dose escalation and expansion studies have been conducted at four medical centers in China to evaluate the safety and efficacy of C-CAR088 in patients with R/R MM who were previously treated with at least 2 lines of therapy including proteasome inhibitors (PIs) and IMiDs. C-CAR088 is administered to patients as a single intravenous dose after a standard 3-day cyclophosphamide/fludarabine conditioning regimen. Results: As of July 15, 2020, 24 patients were infused and 21 patients had evaluable data for safety and clinical response at dose levels of 1.0 x 106 CAR-T cells/kg (n=3), 3 x106 CAR-T cells/kg (n=11) and 4.5~6x106 CAR-T cells/kg (n=7). The median vein to vein time was 16 days. The manufacturing success rate was 100%. The median age of patients dosed was 60 years (range: 45-74 years).The median number of prior lines of therapy was 4 (range: 2-12 prior therapies). There were 17 (81%) patients with at least one and 12 (57.1%) patients with at least two high risk cytogenetic tumor changes. Five patients (23.8%) had bridging therapy. C-CAR088 treatment was well tolerated. 20 of 21 (95%) patients had Grade 1-2 CRS and one patient experienced Grade 3 CRS. Median time to CRS was 6.5 days (range: 1-11 days) and median duration of CRS was 5 days (range: 2-10 days). Four patients (19%) received tocilizumab for CRS treatment. Only one patient experienced a Grade 1 neurotoxicity event. No dose-limiting toxicities were observed and all adverse events were reversible. The best overall response (BOR) included 6 complete responses (CRs), 10 very good partial responses (VGPRs) and 4 partial responses (PRs). Median follow-up was 182 days (range: 30-375 days). The median duration of response has not been reached. In the 3 x106 CAR-T cells/kg dose group, 5/11(45%) patients achieved a CR. The C-CAR088 PK profile in peripheral blood showed a trend of a dose dependent profile. AUC0~28day and Cmax increased and Tmax decreased with dose (P<0.05). Conclusion: The clinical trial results in patients with R/R MM treated with C-CAR088 show a favorable safety profile and promising signs of efficacy. We will continue to evaluate these patients to understand the long-term effect of C-CAR088 in multiple myeloma patients. Clinical trial information: NCT04322292、NCT03815383、NCT03751293、NCT04295018 Research Sponsor: Cellular Biomedicine Group, Inc. Disclosures Zhu: Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Zheng:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Yan:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Lv:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Lan:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Yang:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Huo:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Han:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Zhao:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Qin:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Wu:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Yao:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Zhu:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Ren:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Zhang:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Huang:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Humphries:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company. Yao:Cellular Biomedicine Group Inc: Current Employment, Current equity holder in publicly-traded company.
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Salter, Linda. "Preconditions for post-employment learning: Preliminary results from ongoing research." International Review of Research in Open and Distributed Learning 12, no. 1 (January 31, 2011): 24. http://dx.doi.org/10.19173/irrodl.v12i1.888.
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This article describes the first phase of a two-phase, mixed-method study. The study, now in progress, explores how and to what extent willingness to engage in learning in mature adulthood is influenced by prior experiences and specific individual personality variables, such as perceived locus of control and degree of self-efficacy. Study participants in this phase are 20 active adults over the age of 50 who participate in various formal and informal programs at a YMCA in a suburb of Seattle, Washington. Preliminary results thus far are discussed with respect to how they may inform educators of mature adults in open education settings. A profile of the characteristics of mature adults likely to be engaged in learning activities is beginning to emerge. A larger sample of participants taken from the same population is now being studied to confirm or refute the value of this profile.
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Obidi, Joyce, Patricia Burke, Trishna Goswami, Laura Richman, Dirk Mendel, and Haifeng Bao. "Interrogation Of Signaling Networks In B Cell Malignancies To Improve Classification Of Patient Subsets For Targeted Therapy." Blood 122, no. 21 (November 15, 2013): 1786. http://dx.doi.org/10.1182/blood.v122.21.1786.1786.
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Abstract Targeted therapies have demonstrated promising advances in treatment of B cell malignancies. The premise of this project is that patients with closely related signaling “fingerprints” will have similar biological and clinical features. The objectives were to identify signaling profiles that are associated with clinical features and classify patients based on a signaling signature. 19 DLBCL and CLL cell lines with different molecular features were assessed in this study to establish relevant signaling features. We examined chronic BCR signaling, which leads to the activation of several downstream signaling pathways such as MAPK, AKT and NFκB pathways, in DLBCL and CLL cell lines. Phosphoflow cytometry was used to profile cell lines; a panel of 2 stimulation conditions was combined with 3 phospho-protein readouts. Basal level signal activities in cells were compared to enhance activation with PMA/IONO and F(ab’)2 IgG/IgM. We observed that AKT signaling in cell lines contrasted significantly with signaling in Normal B cells (CD20+ PBMCs). Constitutive activation of the AKT signaling pathways at baseline was observed in DLBCL cell lines; very high basal phosphorylated Ribosomal Protein S6 was observed in ABC (activated B-cell) phenotype DLBCL cell lines. In addition, upon ex vivo stimulation 30% of the cell lines demonstrated high level of pathway activity when compared to normal B cells. In this study we have identified 2 distinct signaling profiles based on BCR signaling in DLBCL cell lines; 7 of 12 DLBCL cell lines demonstrated impaired BCR signaling and 4 of 12 cell lines were hyper responsive to BCR stimulation. In the case of NFκB signaling, ex vivo stimulation revealed an absence of functional NFκB activity in the several cell lines. However, the lack of NFκB pathway activity observed in these cell lines was restored with the use of a phosphatase inhibitor, indicating that impaired signaling is not through loss of kinase function but is due to an increase in negative regulation. We also explored inhibition of pathway activities in response to small molecule inhibitors targeting BCR signaling. The inconsistency in MAPK, AKT, and NFκB pathway activities observed could aid in defining a signaling profile applicable to patient stratification. Overall, our results suggest that profiling of signaling network activities represents a promising approach to molecularly classifying DLBCL and CLL subtypes. Disclosures: Obidi: MedImmune: Employment. Burke:MedImmune: Employment. Goswami:MediImmune: Employment. Richman:MedImmune: Employment. Mendel:Medimmune: Employment. Bao:MediImmune: Employment.
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Pestel, Sabine, Philipp Claar, Jochen Müller-Cohrs, Elmar Raquet, Hendrik Peil, Thomas Weimer, and Eva Herzog. "Pharmacokinetic Properties of Different rFVIII Products in Rabbits, Rats and FVIII Ko Mice." Blood 126, no. 23 (December 3, 2015): 1078. http://dx.doi.org/10.1182/blood.v126.23.1078.1078.
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Abstract Introduction: Current state of the art treatment of severe Hemophilia A is prophylactic or on-demand replacement of the deficient factor VIII (FVIII) using plasma derived or recombinant factors [Keeling 2008; Srivastava 2012; Wong 2011]. The compliance to existing therapies is hampered by the short half-life of available FVIII products necessitating multiple intravenous injections per week for adequate prophylaxis [Bjorkman 2009; Sheridan 2011]. Thus, FVIII products with improved pharmacokinetic profiles are currently under development or have recently been made available [Oldenburg 2014]. FVIII's pharmacokinetic (PK) properties are believed to be strongly dictated by its binding to von Willebrand Factor (VWF) [Lenting 2007; Dasgupta 2007; Saenko 2006]. The aim of this study was to compare the binding affinity of different recombinant FVIII (rFVIII) products to plasma derived VWF (pd VWF), and characterize their PK properties in different animal species. Methods: The PK profiles of rVIII-SingleChain (B-domain-truncated, covalently-linked single chain rFVIII; CSL Behring), Advate® (full-length rFVIII; Baxalta), NovoEight® (B-domain-truncated rFVIII; NovoNordisk), Eloctate® (B-domain-deleted rFVIII fused to Fc portion of IgG; Biogen) and Nuwiq® (B-domain-deleted rFVIII; Octapharma) were compared in FVIII knock out mice (FVIII ko), rats and rabbits following intravenous injection of 150 (mice and rabbits) or 400 or 480 (rats) IU/kg rFVIII. Dose levels were administered based on labelled/nominal chromogenic FVIII activity. Plasma samples were obtained up to 72 h (mice), 48 h (rats) and 96 h (rabbits) post-application. FVIII plasma levels were determined based on antigen (FVIII:Ag) using an ELISA technique (ASSERACHROM®, Stago) and/or based on chromogenic FVIII activity (FVIII:C; COAMATIC® FACTOR VIII, Chromogenix). Results: The PK of rFVIII products in three different animal species was compared using the area under the plasma concentration time curve (AUC) as an indicator for exposure. In FVIII ko mice, FVIII:Ag based PK of rVIII-SingleChain was comparable to that of Eloctate® and NovoEight®, and superior over Nuwiq® and Advate® based on AUC. In contrast, FVIII:C based PK data did not achieve significant differences, most likely due to the the higher assay variability. In rats, FVIII:Ag PK of rVIII-SingleChain was superior over all tested rFVIII products, i.e. Nuwiq®, NovoEight®, Eloctate® and Advate® based on AUC. In rabbits, rVIII-SingleChain FVIII:Ag PK was comparable to NovoEight® and superior to all other rFVIII products, i.e. Nuwiq®, Eloctate® and Advate®. Thus, across all animal species tested, a favorable PK profile was shown for rVIII-SingleChain. It was further shown that the binding affinity of rVIII-SingleChain to pd VWF was significantly improved in comparison to the full length molecule Advate® [Zollner 2014]. This higher binding affinity to pd VWF may therefore explain the differences in PK profiles observed. Conclusion: In general, rVIII-SingleChain showed a favorable PK profile as compared to other rFVIII products such as Advate®, NovoEight®, Eloctate® and Nuwiq® across species, i.e. FVIII ko mice, rats and rabbits. This favorable PK profile of rVIII-SingleChain may be explained by its high binding affinity to VWF. Disclosures Pestel: CSL Behring GmbH: Employment. Claar:CSL Behring GmbH: Employment. Müller-Cohrs:CSL Behring GmbH: Employment. Raquet:CSL Behring GmbH: Employment. Peil:CSL Behring GmbH: Employment. Weimer:CSL Behring GmbH: Employment. Herzog:CSL Behring GmbH: Employment.
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Guisot, Nicolas E. S., Stuart A. Best, Victoria Wright, Andrew Thomason, Jennifer A. Woyach, Rose Mantel, Fabienne McClanahan, et al. "REDX08608, a Novel, Potent and Selective, Reversible BTK Inhibitor with Efficacy and Equivalent Potency Against Wild-Type and Mutant C481S BTK." Blood 128, no. 22 (December 2, 2016): 4399. http://dx.doi.org/10.1182/blood.v128.22.4399.4399.
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Abstract Here we report the preclinical profile of REDX08608 our novel, potent and selective, reversible BTK inhibitor that is equipotent against wild-type and mutant C481S BTK. Bruton's tyrosine kinase (BTK) is a member of the src-related Tec family of cytoplasmic tyrosine kinases and plays a key role in the BCR signaling pathway, which is required for the development, activation and survival of B-cells. BTK is a clinically validated target to treat B-cell malignancies that are dependent on BCR signaling i.e.CLL and NHL with ibrutinib approved for the treatment of CLL, MCL and WM. Irreversible and covalent reversible BTK inhibitors such as ibrutinib, acalabrutinib and GS-4059 specifically target a cysteine residue C481 within BTK and mutations at this site clearly interfere with covalent drug binding. C481S, C481Y, C481R, C481F mutations have been reported and linked to cases of resistance that have emerged in patients with CLL progression following treatment with ibrutinib (Byrd2016, Inhye2016, Maddocks2015, Woaych2014). Redx reversible BTK inhibitor, REDX08608, aims to overcome this resistance mechanism by targeting both wild type and C481-mutated BTK. Redx have recently presented REDX06961 our BTK probe (Guisot2016, AACR#4795) and, following lead optimization, we are now disclosing REDX08608, our lead compound, a potent, reversible and selective BTK inhibitor, which displays an improved profile including superior pharmacokinetics. REDX08608, reversibly, inhibits WT and C481S BTK and displays nanomolar binding affinity and potency in biochemical and cellular-based assays. REDX08608 inhibits BTK signaling and growth in cell lines dependent on the BTK pathway such the OCI-LY10 ABC-DLBCL cell line. Importantly, REDX08608 also inhibits BTK signaling in primary CLL cells. In human whole blood and isolated human PBMCs, REDX08608 inhibits activation of B-cells at nanomolar concentrations measured by inhibition of immunoglobulin-induced CD69 in CD19+cells. REDX08608 is highly selective when tested against a panel of 468 kinases and exhibits improved target specificity with >100-fold selectivity against other Tec and Src kinase family members (ITK, TXK, BMX, TEC, BLK, CSK, FYN, HCK, LCK, SRC) and >400-fold selectivity against EGFR. REDX08608 was fully profiled through DMPK in vitro assays including metabolic stability, plasma stability, cytochrome P450 inhibition, PXR activation/cytochrome P450 activity, time dependent inhibition and cytochrome P450 reaction phenotyping. REDX08608 was shown to have an acceptable metabolic and plasma stability profile across species (mouse, rat, dog, monkey and human). REDX08608 displayed no evidence of PXR activation or time dependent inhibition. IC50s were determined for human cytochrome P450s (1A2, 2D6, 2C9, 2C19 and 3A4) and were all >10 µM. Good exposure, oral bioavailability and half-life were demonstrated for REDX08608 in mouse, rat and dog, with dose linearity assessment performed in mouse (F = 73-100%, CL= 11% liver blood flow in mice; F = 55-84%, CL = 28% liver blood flow in rat; F = 85%, CL= 10% liver blood flow in dog). In vivo efficacy studies in preclinical models will also be disclosed. In conclusion, REDX08608 is a potent and selective, reversible BTK inhibitor with efficacy in lymphoma cell lines that offers the potential to target both wild-type BTK and an important emerging resistance mechanism in patients with CLL progression following ibrutinib-treatment. Disclosures Guisot: Redx Oncology Ltd - Redx Pharma Plc: Employment. Best:Redx Oncology Ltd - Redx Pharma Plc: Employment. Wright:Redx Oncology Ltd - Redx Pharma Plc: Employment. Thomason:Redx Oncology Ltd - Redx Pharma Plc: Employment. Woyach:Acerta: Research Funding; Karyopharm: Research Funding; Morphosys: Research Funding. Abet:Redx Oncology Ltd - Redx Pharma Plc: Employment. Castagna:Redx Oncology Ltd - Redx Pharma Plc: Employment. Cousin:Redx Oncology Ltd - Redx Pharma Plc: Employment. Emmerich:Redx Oncology Ltd - Redx Pharma Plc: Employment. Ho:Redx Oncology Ltd - Redx Pharma Plc: Employment. Kelly:Redx Oncology Ltd - Redx Pharma Plc: Employment. King-Tours:Redx Oncology Ltd - Redx Pharma Plc: Employment. Lyons:Redx Oncology Ltd - Redx Pharma Plc: Employment. Muller:Redx Oncology Ltd - Redx Pharma Plc: Employment. Refuerzo:Redx Oncology Ltd - Redx Pharma Plc: Employment. Sargent:Redx Oncology Ltd - Redx Pharma Plc: Employment. Talab:Redx Oncology Ltd - Redx Pharma Plc: Employment. Bingham:Redx Oncology Ltd - Redx Pharma Plc: Employment. Phillips:Redx Oncology Ltd - Redx Pharma Plc: Employment. Armer:Redx Oncology Ltd - Redx Pharma Plc: Employment.
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Chambel, Maria J., Laura Lorente, Vânia Carvalho, and Isabel Maria Martinez. "Psychological contract profiles among permanent and temporary agency workers." Journal of Managerial Psychology 31, no. 1 (February 8, 2016): 79–94. http://dx.doi.org/10.1108/jmp-02-2014-0070.
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Purpose – Based on the psychological contract (PC) theory, the purpose of this paper is to identify PC profiles, differentiating between permanent and temporary agency workers (TAW). Moreover, the authors analyzed whether different profiles presented different levels of work engagement. Design/methodology/approach – A cross-sectional survey data analysis of 2,867 workers, of whom 1,046 were TAW, was analyzed using latent profile analyses. Findings – Four PC profiles were identified, which differed quantitatively in terms of the overall dimension levels (i.e. balanced, relational and transactional) for PC (i.e. content and fulfillment). ANCOVAs showed that the relational/balanced dominant and transactional dominant profiles presented similar engagement levels for TAW, but for permanent workers the former profile showed higher engagement than the latter. However, for both permanent and TAW the fulfillment profile showed higher engagement than the unfulfillment profile. Research limitations/implications – The cross-sectional design and the reliance on self-report measures are the limitations of this study, although no causality was claimed and method biases were controlled. Practical implications – Actions that increase PC fulfillment positively affect the employment relationship of TAW with the client organization. Originality/value – Few studies have addressed PC typologies. Furthermore, most studies have focussed on temporary workers, but not on TAW and their contract with the client organization. Finally, this study emphasizes the crucial role played by the PC in the levels of work engagement.
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Стукен, Т., and T. Stuken. "THE QUALITY OF EMPLOYMENT OF GRADUATES ON REGIONAL LABOUR MARKETS." Bulletin of Kemerovo State University. Series: Political, Sociological and Economic sciences 2018, no. 2 (March 25, 2018): 33–39. http://dx.doi.org/10.21603/2500-3372-2018-2-33-39.
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<p>The current research features employment of university graduates in the Siberian Federal District. The objective is to assess the quality of employment among higher education system graduates. The study is based on microdata obtained from a survey on employment conducted by the Federal Service of State Statistics (Rosstat). The methodology is based on a comparison of employment haracteristics (the level and profile of education, formal / informal, full / part-time employment) that reflect a possible demand for graduates on the local labour market. The main research methods are descriptive and regression analysis. The obtained results indicate that approximately one third of graduates fail to find work according to their specialty and perform jobs that do not require higher education. Every eighth graduate is employed in the informal sector. These figures indicate a lower quality of employment of graduates in the Siberian Federal District, compared with the average indicators for Russia. A regression analysis has showed that employment in accordance with the level and profile of education is determined mainly by individual characteristics of individuals. The best chances are in the field of medicine, the worst – in agriculture. The assumptions about<br />a high demand for specialists in the field of engineering and technology and a lower demand for specialists in economics and management have not been confirmed. These employment rates turned out to be approximately equal and correspond to average values. The obtained results can be used in the formation of programs of education development (primarily at the level of flagship universities) and improvement of educational programs.</p>
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Akiyama, Tadakazu, Shin-ichiro Takayanagi, Yoshimi Maekawa, Kohta Miyawaki, Fumiaki Jinnouchi, Takashi Jiromaru, Takeshi Sugio, et al. "First Preclinical Report of the Efficacy and PD Results of KHK2823, a Non-Fucosylated Fully Human Monoclonal Antibody Against IL-3Rα." Blood 126, no. 23 (December 3, 2015): 1349. http://dx.doi.org/10.1182/blood.v126.23.1349.1349.
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Abstract Human interleukin-3 receptor alpha (IL-3Ra, CD123), which promotes the proliferation and differentiation of hematopoietic cells, is highly expressed in myeloid malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We newly generated KHK2823, a non-fucosylated fully human IgG1 monoclonal antibody against human IL-3Ra, by utilizing the POTELLIGENT® technology. Here, we describe the in vitro and in vivo preclinical efficacy and safety of KHK2823, as well as its pharmacodynamic (PD) profile. At first, we explored that KHK2823 bound to various hematological malignant cells and leukemic stem cells. The cells from AML and MDS bone marrows were found to be bound by KHK2823. A significant part of bone marrow cells derived from B-cell acute lymphoblastic leukemia (B-ALL) patients was also bound by KHK2823. KHK2823 bound to soluble human IL-3Ra protein with a sub-nanomolar dissociation constant (KD), and recognized CD34+ CD38+ (leukemic blast) and/or CD34+ CD38- (leukemic stem cell) cells in patients with AML/MDS, as well as AML cell lines, thereby obtaining a high antibody-dependent cellular cytotoxic activity without complement-dependent cytotoxicity. Interestingly, KHK2823 did not interfere with the binding of IL-3 to IL-3R. The lack of a receptor-ligand interaction may conserve the IL-3 signal, which plays an important role in normal hematopoiesis. In a tumor model xenografting the human AML cell line MOLM-13 on nude rats, KHK2823 significantly suppressed the tumor growth at doses of 0.1 and 1 mg/kg (Figure 1). The PD and toxicity profiles of KHK2823 were assessed in cynomolgus monkeys administered at doses ranging from 0.1 to 100 mg/kg by i.v. infusion, once weekly for 4 weeks. KHK2823 was generally well tolerated in monkeys, even at 100 mg/kg. The number of IL-3Ra-positive cells in the peripheral blood of cynomolgus monkeys decreased in all groups receiving KHK2823, which suggest KHK2823 could exert its depletion activity of IL-3Ra-positive cells in human (Figure 2). Currently, the safety and tolerability of KHK2823 is being investigated in patients with AML or MDS in a Phase 1 study (NCT02181699, https://clinicaltrials.gov/ct2/show/NCT02181699). This is the first non-randomized, open-label, dose escalation clinical study to investigate the safety, PK, immunogenicity and PD of repeated doses of KHK2823. In summary, KHK2823 was confirmed to bind to AML, MDS and B-ALL cells as the IL-3Ra in accordance with other publications. KHK2823 was also found to eliminate AML cells in vitro and also suppressed the AML tumor growth in the in vivo model. In addition, the number of IL-3Ra-positive cells in cynomolgus monkeys decreased following i.v. infusion of 0.1mg/kg KHK2823 with a tolerable safety profile, even at a dose of 100 mg/kg. Taken together, KHK2823 may therefore be a promising anti-IL-3Ra therapeutic drug for the treatment of AML. Figure 1. Antitumor activity of KHK2823 in a tumor xenograft nude rat model Figure 1. Antitumor activity of KHK2823 in a tumor xenograft nude rat model Figure 2. PD profile of KHK2823 in cynomolgus monkeys Figure 2. PD profile of KHK2823 in cynomolgus monkeys Disclosures Akiyama: Kyowa Hakko Kirin Co., Ltd.: Employment. Takayanagi:Kyowa Hakko Kirin Co., Ltd.: Employment. Maekawa:Kyowa Hakko Kirin Co., Ltd.: Employment. Shimabe:Kyowa Hakko Kirin Co., Ltd.: Employment. Nishikawa:Kyowa Hakko Kirin Co., Ltd.: Employment. Yamawaki:Kyowa Hakko Kirin Co., Ltd: Employment. Iijima:Kyowa Hakko Kirin Co., Ltd: Employment. Hiura:Kyowa Hakko Kirin Co., Ltd.: Employment. Takahashi:Kyowa Hakko Kirin Co., Ltd.: Employment. Akashi:Asahi Kasei: Research Funding, Speakers Bureau; Chugai: Research Funding, Speakers Bureau; Bristol-Myers Squibb: Research Funding, Speakers Bureau; Novartis Pharma K.K.: Consultancy, Research Funding, Speakers Bureau; Kyowa Hakko Kirin Co., Ltd.: Consultancy, Research Funding, Speakers Bureau; Celgene: Research Funding, Speakers Bureau; Shionogi: Research Funding, Speakers Bureau; Astellas: Research Funding, Speakers Bureau. Tawara:Kyowa Hakko Kirin Co., Ltd: Employment.
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Malik, Ishfaq Ahmad, and Ajaz Ahmad Rather. "Deteriorating agriculture: it's reasons and impacts on socio-economic profile of J&K state." Asian Journal of Agriculture and Rural Development 7, no. 8 (March 9, 2018): 149–59. http://dx.doi.org/10.18488/journal.1005/2017.7.8/1005.8.149.159.
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In terms of dependence on livelihoods and employment, the state of Jammu and Kashmir can be considered as agrarian, hence the overwhelming majority of the people live in rural areas. There are many reasons that have led to a dwindling share of GDP of the sector at a time when it should have retained its role given large proportion of people depending on it. These include: Reduction in public expenditure in the sector after reforms, decrease in agricultural land due to conversion, lack of appropriate irrigation facilities, and acute lack of infrastructure, lack of quality pesticides, occasional flooding, and lack of research. This imbalance between production and employment has resulted into compromised socio-economic profile of the state which includes: Low per capita income, compromised Food security, large Capital outflow, and Low employment. Therefore, in a bid to arrest any further deterioration in its socioeconomic profile, it is imperative for the state to initiate a stream of measures that will enhance the productivity in the sector and safeguard it from undue competition from abroad.
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Robinson, Laura D., Christopher A. Magee, and Peter Caputi. "Work-to-family profiles, family structure and burnout in mothers." Journal of Managerial Psychology 31, no. 7 (September 12, 2016): 1167–81. http://dx.doi.org/10.1108/jmp-03-2015-0102.
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Purpose The purpose of this paper is to identify work-to-family profiles in working mothers, test whether profiles differ between sole and partnered mothers, and examine whether the work-to-family profiles are associated with burnout. Design/methodology/approach Data on work-to-family conflict (WFC), work-to-family enrichment (WFE), burnout, and relevant socio-demographic covariates were collected via a self-report online survey. Latent profile analysis on WFC and WFE items was used to identify profiles in 179-sole and 857-partnered mothers in paid employment. Regression analyses were performed to examine whether profiles were associated with burnout. Findings Five distinct work-to-family profiles were identified: Harmful, Negative Active, Active, Beneficial, and Fulfilled. Profile membership differed significantly between sole and partnered mothers, with sole mothers more likely to be in the harmful profile. The five profiles had differing implications for burnout. Practical implications WFC and WFE can co-occur, and have differing implications for health and well-being. It is important to consider both WFC and WFE when addressing employee burnout. Furthermore, sole mothers may need greater assistance in reducing WFC and increasing WFE in order to minimize burnout. Originality/value This study contributes to existing research by demonstrating differences in work-to-family profiles between sole and partnered mothers, and highlights the need for future research on diverse family types.
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Bartlett, Irene, and Diana Tolmie. "What are you doing the rest of your life? A profile of Jazz/Contemporary Voice graduates." International Journal of Music Education 36, no. 2 (August 17, 2017): 197–216. http://dx.doi.org/10.1177/0255761417714606.
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Over the past two decades the topic of graduate outcomes has increasingly informed the discourse on the changing nature of universities. For conservatoires and university music departments the global shift in audience demand away from western classical music and jazz styles (traditionally the cornerstone tertiary music programs) to contemporary commercial music (CCM) has added an extra dimension to the graduate outcomes discussion with respect to vocation preparation and musicians’ portfolio careers. Few studies have tracked the career paths of music graduates across time with none focused on jazz/contemporary singers. This report discusses the findings from a snapshot study of Jazz/Contemporary Voice graduates (2001 to 2012) of one Australian conservatoire. The purpose of this research was to better describe this population of graduates in terms of employment outcomes, the dynamics of their employment activities, employment-seeking strategies and the relevance of university coursework to their employability. Their responses have implications for tertiary music training programs.
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Perez, Arianne, Lynn Navale, John M. Rossi, Yueh-wei Shen, Yizhou Jiang, Marika Sherman, Armen Mardiros, et al. "Pharmacodynamic Profile and Clinical Response in Patients with B-Cell Malignancies of Anti-CD19 CAR T-Cell Therapy." Blood 126, no. 23 (December 3, 2015): 2042. http://dx.doi.org/10.1182/blood.v126.23.2042.2042.
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Abstract This study is supported in part by funding from the CooperativeResearch and Development Agreement (CRADA) between the National Cancer Institute and Kite Pharma Introduction: Chimeric antigen receptor (CAR) engineered autologous T-cell therapy has shown promising efficacy in B-cell malignancies in an ongoing phase 1 study (Kochenderfer et al. J Clin Oncol 2014). Anti-CD19 CAR T-cell product characteristics and potential pharmacodynamic markers from patients in this study were evaluated together with updated clinical responses. Methods: In this National Cancer Institute (NCI) clinical trial (NCT00924326), patients with relapsed/refractory B-cell malignancies received conditioning with cyclophosphamide and fludarabine daily for 3 days starting on day -5; followed by 1-2 x 106/kg anti-CD19 CAR T cells engineered with a CAR expressing CD28 and CD3-zeta signaling domains. Forty one cytokines, chemokines and immune response related markers were measured in the serum of patients prior to conditioning and CAR T-cell infusion, and during an interval of 4 weeks post-CAR T-cell infusion. EMD Millipore Luminex® xMAP® multiplex assays were used to measure all analytes. A Luminex 200™ instrument and xPONENT® 3.1 software were used for data acquisition and analysis. Major T-cell phenotypic markers including CD4, CD8, CD45RA and CCR7 were evaluated by multicolor flow cytometry on CAR-expressing T cells prior to and post-infusion, using a BD FACSCanto II. FlowJo software was used for data analysis. T-cell marker expression, as well as cytokine and chemokine levels were analyzed together with the clinical response to anti-CD19 CAR T cells. Maximum fold increase (MFI) was defined as the maximum fold change of measured analytes above baseline (pre-conditioning, day -5) across sampling timepoints. Results: Anti-CD19 CAR T-cell products, PBMCs from 12 patients, and serum samples from 15 patients have been evaluated. In 12 patient lots evaluated to date, the median CD4+/CD8+ CAR T-cell ratio was 0.48 (range 0.02-6.12). In addition, the median ratio between naïve (TN) plus central memory T cells (TCM), and more differentiated effector memory (TEM) plus effector cells (TE), was 0.48 (range 0.1-16.8). Post-hoc analyses adjusted for multiple comparisons showed that the frequency of CD4+ TN and TCM cells in the 6-8 day T-cell lots was significantly greater than that of CD4+ TN and TCM cells in the 10 day T-cell lots. The corresponding frequencies of CD8+ TN and TCM cells in the 6-8 day T-cell lots compared to 10 day T-cell lots approached significance, but did not meet the threshold after multiplicity adjustment. Clinical responses were seen across broad ranges of CD4+/CD8+ and (TN+TCM)/(TEM+TE) ratios in the CAR T-cell product. CAR T cells upregulated T-cell activation and immune modulating markers, as well as released measurable levels of cytokines and chemokines in response to CAR engagement of CD19 in vitro, or post-infusion. Cytokine and chemokine levels achieved their peak 3-10 days post T-cell infusion and returned to baseline generally within 3 weeks. Key pro-inflammatory cytokines and markers were upregulated: IL-6 median fold increase (MFI) at peak of 66 (interquartile range 5-152), IFN-g MFI 57 (13-126), C-reactive protein MFI 6 (4-42); immune homeostatic cytokines IL-15 MFI 19 (7-54), IL-2 MFI 20 (4-22), IL-10 MFI 10 (4-15); chemokines monocyte chemotactic protein (MCP)-1 MFI 7 (5-9), MCP-4 MFI 4 (2-5); and the immune effector molecules granzyme A MFI 7 (6-17) and granzyme B MFI 5 (3-9). Further analyses are ongoing. Conclusion: Clinical responses were observed irrespective of the CD4+/CD8+ ratio in the CAR T cell product. Cytokines and immune effector mediators peaked and cleared within 3 weeks. This pharmacodynamic profile reveals a rapid and coordinated sequence of T cell activation underlying durable responses in patients with B-cell malignancies. Disclosures Perez: Kite Pharma: Employment, Equity Ownership. Navale:Kite Pharma: Employment, Equity Ownership; Amgen: Equity Ownership. Rossi:Kite Pharma: Employment, Equity Ownership; Amgen: Equity Ownership. Shen:Kite Pharma: Employment, Equity Ownership. Jiang:Kite Pharma: Employment, Equity Ownership. Sherman:Amgen: Equity Ownership; Kite Pharma: Employment, Equity Ownership. Mardiros:Kite Pharma: Employment, Equity Ownership. Yoder:Kite Pharma: Employment, Equity Ownership. Go:Kite Pharma: Employment, Equity Ownership; Amgen: Equity Ownership. Rosenberg:Kite Pharma: Other: CRADA between Surgery Branch-NCI and Kite Pharma. Wiezorek:Kite Pharma: Employment, Equity Ownership, Other: Officer of Kite Pharma. Roberts:Kite Pharma: Employment, Equity Ownership, Other: Officer of Kite Pharma. Chang:Kite Pharma: Employment, Equity Ownership, Other: Officer of Kite Pharma. Bot:Kite Pharma: Employment, Equity Ownership.
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Marubayashi, Sachie, Adam Park, Rajkumar Noubade, Huyen Phan, Gene Cutler, Paul Kassner, and Jordan S. Fridman. "FLX925 Is a Rationally Designed FLT3, CDK4/6 Inhibitor with a Desirable Resistance Profile." Blood 128, no. 22 (December 2, 2016): 2323. http://dx.doi.org/10.1182/blood.v128.22.2323.2323.
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Abstract Acquired secondary resistance mutations in FLT3 have been shown to limit the therapeutic benefit of FLT3 inhibitors in FLT3-ITD mutated AML. Multiple strategies have been pursued to address such resistance, including the development of kinase inhibitors that use alternate binding modes or by simultaneously targeting additional pathways. This latter approach may be focused on suppression of parallel oncogenic pathways to treat the acquired resistance, or on strategies to reduce or delay the acquisition of resistance. Here, we describe a rationally conceived next generation FLT3 inhibitor, FLX925, that was prospectively designed to address or avoid common resistance mechanisms with a unique binding mode and potent activity against CDK4/CDK6. We contextualize our findings by comparing FLX925 to other FLT3 inhibitors (quizartinib and gilteritinib) currently in late-stage clinical development and demonstrate that FLX925 has a superior resistance profile. FLX925 is a potent and selective type-1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3. This was evaluated in multiple experimental systems including isogenic Ba/F3 cells engineered to express FLT3-ITD with, or without, various known secondary FLT3 mutations. In addition, these data were extended to the human setting using both the MOLM13 and MOLM14 FLT3-ITD mutated AML cell lines and subclones of these lines harboring well-characterized resistance mutations described elsewhere. Data have been published previously demonstrating a superior resistance profile for FLX925 when compared to quizartinib and sorafenib. When compared to gilteritinib, FLX925 had a favorable profile of relative potencies against a range of FLT3-ITD resistance mutations. In addition to the isogenic murine and human models of FLT3 inhibitor resistance, with engineered known genetic alterations, we explored the activity of FLX925 and other FLT3 inhibitors in a model of in vitro acquired resistance. Using MOLM13 cells and standard protocols for the generation of drug resistance, we demonstrate that the magnitude of resistance to quizartinib and gilteritinib greatly exceeds that observed with FLX925 during the same timeframe. Pools of resistant cells from each compound treatment are being analyzed by next-generation sequencing in an effort to better understand the mechanism of resistance associated with each compound. We hypothesize that the CDK4/6 inhibitory activity, which is unique to FLX925, contributes to its superior resistance profile. Whether this is solely linked to an impact on the cell cycle or more recent findings of CDK6-driven transcription of FLT3 and PIM1 is an active area of investigation. Nonetheless, the CDK4/6 activity of FLX925 potentially broadens the utility of this compound to FLT3 wild-type AML. Here, we show FLX925, in contrast to other FLT3 inhibitors, potently suppresses the proliferation of a panel of AML cell lines. These data have been extended to FLT3 wild-type AML patient samples in which FLX925, but not gilteritnib, induced a desirable pharmacodynamic effects. The totality of the preclinical data suggest FLX925 may be a best-in-class inhibitor for the treatment of AML with, or without, FLT3-ITD mutations. FLX925 is currently being investigated in a Ph1/b dose-escalation study in subject with relapsed or refractory AML (NCT02335814). Disclosures Marubayashi: FLX Bio: Employment, Equity Ownership. Park:FLX Bio: Employment, Equity Ownership. Noubade:FLX Bio: Employment, Equity Ownership. Phan:FLX Bio: Employment. Cutler:FLX Bio: Employment, Equity Ownership; Amgen, Inc: Equity Ownership. Kassner:FLX Bio: Employment, Equity Ownership. Fridman:FLX Bio: Employment, Equity Ownership.
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Patino-Alonso, Maria-Carmen, Maria-Purificación Vicente-Galindo, Maria-Purificación Galindo-Villardón, and Jose-Luis Vicente-Villardón. "Multivariate profile of women who work in rural settings in Salamanca, Spain." Journal of Sociology 52, no. 4 (July 10, 2016): 806–23. http://dx.doi.org/10.1177/1440783315594485.
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We examine the job situation of women living in rural Salamanca, Spain, using principal coordinates analysis to identify the profile of these women (specifically, those with declared vs. undeclared jobs) and explore what they believe would improve their employment situations. Four well-differentiated groups were identified: two groups included rural women with ‘regular’ jobs and two groups included women with ‘irregular’ jobs, where ‘irregular’ work is defined as work that involves a decrease in taxes destined for the Social Security system. These women were differentiated based on their marital status and the job sector in which they worked. Women with an ‘irregular’ employment status stated that they would prefer to work in a ‘regular’ job with a job contract and make contributions to the Social Security system in accordance with the true number of hours they work. Such a job situation guarantees access to all available social benefits.
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Lignet, Florian, Christina Esdar, Manja Friese-Hamim, Andreas Becker, Elise Drouin, Samer El Bawab, Samantha M. Goodstal, et al. "Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients." Blood 134, Supplement_1 (November 13, 2019): 5582. http://dx.doi.org/10.1182/blood-2019-126972.
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M3258 is an orally bioavailable, potent, selective, reversible inhibitor of the large multifunctional peptidase 7 (LMP7, β5i, PSMB8) proteolytic subunit of the immunoproteasome; a crucial component of the cellular protein degradation machinery, which is highly expressed in malignant hematopoietic cells including multiple myeloma. M3258 was previously shown to deliver strong in vivo preclinical efficacy in multiple myeloma xenograft models, as well as a more benign non-clinical safety profile compared to approved pan-proteasome inhibitors, exemplified by a lack of effects on the central and peripheral nervous systems and cardiac and respiratory organs. Here we describe preclinical PK/PD and PK/efficacy modelling which led to a prediction of the PK profile, and the efficacious and safe dose ranges of M3258 in human which were used to guide the design of the phase I dose-escalation trial of M3258 in >3 line relapsed/refractory multiple myeloma (RRMM) patients. Mouse, rat, dog and monkey PK, plasma protein binding and intrinsic clearance data were used to estimate a half-life of approximately 6 hours for M3258 in human. The human total clearance and volume of distribution for M3258 were predicted to be 0.033 L/h/kg and 0.28 L/kg, respectively, whilst oral bioavailability was estimated to be above 80%. LMP7 proteolytic activity was assessed as a PD readout in human multiple myeloma tumor cells xenografted to mice as well as in dog peripheral blood mononuclear cells (PBMCs). A strong PK/PD relationship was observed for M3258 across both species. LMP7 inhibition by M3258 also correlated strongly with anti-tumor efficacy in multiple myeloma xenografts, with maximal efficacy observed at M3258 exposure delivering sustained inhibition of tumor LMP7 activity. Quantitative PK/PD/efficacy modeling predicted the biologically efficacious dose (BED) of M3258 upon oral application to be between 10 - 90 mg daily in human. By incorporating data from nonclinical safety studies, these data suggest an attractive human PK profile of M3258, enabling oral application, as well as an improved human therapeutic index compared to approved pan-proteasome inhibitors. M3258 is being investigated in a phase I, first-in-man, 2-part, open label clinical study designed to determine the safety, tolerability, PK, PD and early signs of efficacy of M3258 as a single agent (dose-escalation) and co-administered with dexamethasone (dose-expansion) in participants with RRMM whose disease has progressed following > 3 prior lines of therapy and for whom no effective standard therapy exists. Integration of these data will guide the selection of the BED for potential further clinical development of M3258. Disclosures Lignet: Merck Healthcare KGaA: Employment. Esdar:Merck Healthcare KGaA: Employment. Friese-Hamim:Merck Healthcare KGaA: Employment. Becker:Merck Healthcare KGaA: Employment, Other: Holding shares with a value below 1000-USD. Drouin:EMD Serono Research and Development Institute: Employment. El Bawab:Merck Healthcare KGaA: Employment. Goodstal:EMD Serono Research and Development Institute: Employment. Gimmi:Merck Healthcare KGaA: Employment. Haselmayer:Merck Healthcare KGaA: Employment. Jährling:Merck Healthcare KGaA: Employment. Sanderson:Merck Healthcare KGaA: Employment. Sloot:Merck Healthcare KGaA: Employment. Stinchi:Merck Healthcare KGaA: Employment. Victor:Merck Healthcare KGaA: Employment. Walter:Merck Healthcare KGaA: Employment. Rohdich:Merck Healthcare KGaA: Employment.
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SAIAPINA, S. А., and О. Н. KОRKISHKO. "Electronic portfolio as a means of successful employment of graduates of pedagogical profile." Humanities Bulletin of Zaporizhzhe State Engineering Academy, no. 75 (February 18, 2019): 143–59. http://dx.doi.org/10.26661/2072-7941.2018.155560.
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Dhulgand, V. G., and R. P. Kadam. "Estimating Profile of the Beneficiaries of Mahatma Gandhi National Rural Employment Guarantee Act." International Journal of Current Microbiology and Applied Sciences 8, no. 12 (December 10, 2019): 1800–1807. http://dx.doi.org/10.20546/ijcmas.2019.812.216.
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Mahesh, Lankati, V. Sudharani, Akkamadevi Naik, K. B. Suneetha Devi, and M. Jagan Mohan Reddy. "Employment Generation of Tribal Farmers of Adilabad and Their Relationship with Profile Characteristics." International Journal of Current Microbiology and Applied Sciences 6, no. 7 (July 10, 2017): 593–99. http://dx.doi.org/10.20546/ijcmas.2017.607.072.
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Deblois, Evan Carlo. "The Employment Profile of Graduates in a State University in Bicol Region, Philippines." Journal of Education, Management and Development Studies 1, no. 1 (June 26, 2021): 33–41. http://dx.doi.org/10.52631/jemds.v1i1.10.
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The conduct of a tracer study is a potent tool that documents the profile of the graduates which gives implications of how well pre-service training is given. This study focused on the employment profile of the graduates of Bicol University Gubat Campus, Philippines from 2015 to 2017 and analyzed the congruence of courses taken and the employment of the graduates. It gathered feedback from the employers of the graduates as to extent of the competencies they demonstrated in the performance of the job assigned to them. The study covered the seven (7) courses offered namely: Bachelor in Secondary Education, Bachelor of Elementary Education, AB in Peace Studies, BS in Computer Science, BS in Entrepreneurship, BSBA major in Microfinance, and Bachelor of Agricultural Technology. Using the descriptive data analysis method, the study probed on the frequency of responses of its key informants/subjects. Data generated were taken from two sets of instruments administered to both graduates and their employers. Results revealed that the graduates are employable. Most of the graduates were in jobs that are highly congruent with their school training. However, the college must still take measures to improve the skills of the graduates.