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Dissertations / Theses on the topic 'Embryonic'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Montgomery, Sarah Lynn. "Impedance measurement system for embryonic stem cell and embryoid body cultures." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24661.

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2

Salanga, Matthew Charles. "EMBRYONIC VASCULAR DEVELOPMENT." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/203435.

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The formation of the embryonic vasculature is essential for life. The components driving this process are well conserved across vertebrate species. At the core of vascular development is the specification of endothelial precursor cells from nascent mesoderm. Transcription factors of the ETS family are important regulators of endothelial specification. In this document we characterize the role of the ETS transcription factors, ETV2, during embryonic vascular development.Expression analysis shows that Etv2 is highly expressed in hematopoietic and endothelial precursor cells in the Xenopus embryo

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3

Bailleul, Richard. "Embryonic patterning of the avian skin : mathematical modelling of embryonic dynamics." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS022.pdf.

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Depuis la publication par Alan Turing de son article ‘The Chemical Basis of Morphogenesis” en 1952, une révolution moléculaire a eu lieu en biologie et les mathématiciens ont fourni un nombre croissant de cadres théoriques afin de modéliser des motifs observés dans la nature. Cette thèse a pour objectif d’unifier les récentes découvertes dans ces deux domaines en proposant un cadre théorique et des schémas de développement pour l’émergence des motifs cutanés aviaires par l’étude de la dynamique de formation du plumage dorsal. J'ai caractérisé l'apparition des primordiums de plumes dans le dos

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4

Nortjé, Nico. "The moral status of embryonic stem cell research in the South African context /." Link to the online version, 2007. http://hdl.handle.net/10019.1/1372.

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5

Harrison, Sarah Ellys. "Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275424.

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Successful mammalian development to term requires that embryonic and extra-embryonic tissues communicate and grow in coordination, to form the body. After implanting into the uterus, the mouse embryo is comprised of three cell lineages: first, the embryonic epiblast (EPI) that forms the embryo proper, second, the extra-embryonic ectoderm (ExE) which contributes to the foetal portion of the placenta, and third, the visceral endoderm (VE) that contributes to the yolk sac. These three tissues form a characteristic ‘egg-cylinder’ structure, which allows signals to be exchanged between them and set

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6

Fijnvandraat, Arnoldus Cornelis. "Embryonic stem cell-derived cardiomyocytes." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/68354.

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7

Brochu, Richard. "Pacemaking in embryonic chick heart." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59533.

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Experiments were conducted to determine the currents involved in the pacemaker activity of aggregates and single cells from the embryonic chick heart. Two microelectrode voltage clamp studies of embryonic chick ventricular heart cell aggregates revealed two time-dependent current components in the pacemaker range of potentials ($-$60 to $-$120 mV). Barium (Ba, 5 mM) blocked the more negatively activated time-dependent component unmasking a component which remained inwardly directed for hyperpolarizing steps beyond the potassium equilibrium potential (E$ sb{ rm K}$). This component, which was b

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8

McCluskey, Jane T. "Mechanisms of embryonic wound healing." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318851.

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9

Tata, M. A. J. "Vascular regulation of embryonic neurogenesis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1531030/.

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Neural progenitor cells (NPCs) in the embryonic nervous system generate a large number and variety of neurons in a process known as neurogenesis. NPCs reside in a regulatory ‘niche’ that provides an extensive array of diverse signals, and loss of any one of these signals can deplete the pool of NPCs and therefore impair neural development. These niche signals are most commonly studied in the forebrain, where a complex array of cell divisions yields a set of diverse NPCs. In contrast, little is known on the role of niche signals in regulating the behaviour of NPCs in the hindbrain, the evolutio

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10

Losa, Llabata Marta. "Gene regulation in embryonic development." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/gene-regulation-in-embryonic-development(8a9efb79-1ca9-409e-89b9-9d66213e593f).html.

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Branchial arches (BAs) are a series of transient structures that develop on the ventro-lateral surface of the head in vertebrate embryos. BAs initially appear as a series of similar segments; as development proceeds each BA will contribute to different structures. Here, it was investigated the transcriptional mechanisms that instruct the different fates of the BAs in development. Initially, each BA contains a blood vessel, known as aortic arch (AA) artery, that connects the dorsal aorta with the heart. Remodelling of the AAs is crucial to form the adult heart circulation. This process leads to

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11

Sargent, Carolyn Yeago. "Effects of hydrodynamic culture on embryonic stem cell differentiation: cardiogenic modulation." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34710.

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Stem and progenitor cells are an attractive cell source for the treatment of degenerative diseases due to their potential to differentiate into multiple cell types and provide large cell yields. Thus far, however, clinical applications have been limited due to inefficient differentiation into desired cell types with sufficient yields for adequate tissue repair and regeneration. The ability to spontaneously aggregate in suspension makes embryonic stem cells (ESCs) amenable to large-scale culture techniques for the production of large yields of differentiating cell spheroids (termed embryoid b

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12

Schacker, Maria Anna. "Defining the transcriptional and epigenetic signature of mouse embryonic stem cells with compromised developmental potency." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287725.

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Mouse embryonic stem (ES) cells have played a crucial role in studying developmental processes and gene function in vivo. They are extremely useful in the generation of transgenic animals as they can be genetically manipulated and subsequently microinjected into blastocyst stage embryos, where they combine with the inner cell mass and contribute to the developing embryo. Some of the resulting pups are chimaeric, consisting of a mixture of cells derived from the host blastocyst and the injected ES cells. We have identified several ES cell clones arising from gene targeting experiments with an i

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13

Van, Vranken Benjamin Eugene. "The influence of embryonic lung mesenchyme on the differentiation of embryonic stem cells in co-culture." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416628.

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14

Anderson, Kathryn Gayle Victoria. "Conserved mode of endoderm induction acts to promote context dependent embryonic and extra-embryonic lineage specification." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/16473.

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In mammalian development, endoderm formation occurs in two phases and the fate of these populations is different. In the blastocyst, inner cell mass (ICM) cells generate the primitive endoderm (PrE), which will give rise to the extra-embryonic parietal (PE) and visceral endoderm (VE). Hematopoietically expressed homeobox (Hhex) protein is initially expressed throughout the PrE and subsequently becomes restricted to the anterior visceral endoderm (AVE), one of two important early embryonic signalling centres in the mouse. During gastrulation a second wave of endoderm differentiation occurs, the

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15

Wilde, Mark H. "The relationship between embryonic diversity and embryonic loss during the first twelve days of porcine gestation /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487676261010897.

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16

Vaahtokari, Anne. "Molecular mechanisms in embryonic tooth development." Helsinki : Dept. of Dentistry, Division of Pedodontics and Orthodontics, Institute of Biotechnology and Dept. of Biosciences, Division of Biochemistry, University of Helsinki, 1996. http://catalog.hathitrust.org/api/volumes/oclc/35253532.html.

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17

Jurczak, Daniel. "Stemness in human embryonic stem cells." Thesis, University of Skövde, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3509.

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<p>Stem cells are cells that have a unique ability to divide for an indefinite period. Additionally, they can give rise to a plethora of specialized cell types. The advent of high-throughput technologies made it possible to investigate gene expression on a large scale. This enabled scientists to perform comprehensive gene profiling studies of stem cells. Several authors have suggested that there might be a common set of genes that control the stemness of stem cells. In this study, we suggest that ”stemness” genes that are related to ”stemness” characteristics show a statistically significant d

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18

Shivji, Nadia. "GnRH neuron migration during embryonic development." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611556.

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19

Jörg, David Josef. "Genetic Oscillations and Vertebrate Embryonic Development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-159034.

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Recurrent processes are a general feature of living systems, from the cell cycle to circadian day-night rhythms to hibernation and flowering cycles. During development and life, numerous recurrent processes are controlled by genetic oscillators, a specific class of genetic regulatory networks that generates oscillations in the level of gene products. A vital mechanism controlled by genetic oscillators is the rhythmic and sequential segmentation of the elongating body axis of vertebrate embryos. During this process, a large collection of coupled genetic oscillators gives rise to spatio-temporal

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20

Page, Nigel Mark. "Gene insertion into avian embryonic cells." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333871.

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21

Abdullah, A. R. "Mathematical modelling of embryonic tissue development." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3028456/.

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22

Mazzocchi-Jones, David. "Electrophysiological characterisation of embryonic striatal grafts." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55058/.

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The striatum, a region of the rodent forebrain, is part of an interconnected set of structures known as the basal ganglia and has long been implicated in the initiation and control of motor behaviour (Graybiel et al., 1994 Groenewegen, 2003). However, emerging evidence suggests that the basal ganglia also plays a role in a variety of other cognitive functions such as motor learning, habit formation, and goal rewarded behaviour (Graybiel, 2000 Oberg and Divac, 1975).

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23

Cheung, Kwok Kuen. "Purinergic signaling during rat embryonic development." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446895/.

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Adenosine 5'-triphosphate (ATP) has been shown to be an important extracellular signaling molecule that mediates various physiological activities via the P2 (P2X and P2Y) receptors. However, information on the expression patterns of the P2 receptors during mammalian embryogenesis is limited. We therefore examined the expression patterns of different P2 receptor subtypes in rat embryos. In the hindbrain neural tube, the P2X3 receptor was transiently expressed at embryonic day E11 in the cranial motor neurons and the outgrowing axons. ATP significantly inhibited neurite outgrowth from neural tub

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24

Ma, Pei. "OPTICAL IMAGING OF EMBRYONIC CARDIAC CONDUCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1464714110.

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25

Cunningham, Michael Lawrence. "The embryonic macrophage : scavenger or sculptor? /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/5687.

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26

Meadows, Stryder. "Transcriptional Regulation In Early Embryonic Development." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194034.

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Transcription factors are a class of proteins that function to regulate the expression of genes. During early development, their role is to provide the precise order of activation or suppression of genes that are required for the formation of an embryo. A major goal of a developing embryo is to establish a complete body plan that includes the development of all of the organ systems. Thus it is paramount that the correct genes are switched on or off to insure that all organ systems form.Our studies investigate the role of several transcription factors involved in coordinating the expression

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27

Jung, Marc [Verfasser]. "OCT4 regulated transcription networks in human embryonic stem cells and human embryonal carcinoma cells / Marc Jung." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023957345/34.

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28

Basuki, Edi 1957. "Ecdysteroid levels and implications for embryonic and post-embryonic development of the blowfly Lucilia cuprina (Wied.) (Diptera:Calliphoridae)." Monash University, Dept. of Biological Sciences, 2000. http://arrow.monash.edu.au/hdl/1959.1/8436.

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29

Lau, Daniel Christian Crews Stephen T. "Embryonic regulation and post-embryonic function of the single-minded gene in the Drosophila central nervous system." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2529.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Oct. 5, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology." Discipline: Biology; Department/School: Biology.

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30

Ladd, Sabine Margaret. "Effects of Diethylstilbestrol on Murine Early Embryonic Stem Cell Differentiation Using an Embryoid Body Culture System." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/31999.

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Objectives: The effects of estrogens on immune system formation and function are well documented. Diethylstilbestrol (DES), a synthetic estrogen, has been linked to neoplasia and immune cell dysfunction in humans and animals exposed in-utero. In-vitro effects of DES exposure of murine embryonic stem (ES) cells on the early embryonic immune system development and the expression of cellular surface markers associated with common hemangioblastic and hematopoietic precursors of the endothelial, lymphoid & myeloid lineages were investigated. Hypothesis: Early ES cell expression of CD45 a mar

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31

Ericson, Robin J. "Bridging solutions to the religion and science conflict over human embryonic stem cell research." Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2926.

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Thesis (Ph. D.)--George Mason University, 2007.<br>Title from PDF t.p. (viewed Jan. 17, 2008). Thesis director: Richard E. Rubenstein. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Conflict Analysis and Resolution. Vita: p. 228. Includes bibliographical references (p. 222-227). Also available in print.

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32

Matsuura, Rie, Hiroshi Kogo, Takunori Ogaeri, et al. "Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells." Alpha Med Press, 2006. http://hdl.handle.net/2237/7444.

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33

Sullivan, Denise D. "Incorporation of bio-inspired microparticles within embryonnic stem cell aggregates for directed differentiation." Thesis, Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54909.

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Embryonic stem cells (ESCs) are a unique cell population that can differentiate into all three embryonic germ layers (endoderm, mesoderm, and ectoderm), rendering them an invaluable cell source for studying the molecular mechanisms of embryogenesis. Signaling molecules that direct tissue patterning during embryonic development are secreted by ESC aggregates, known as embryoid bodies (EBs). As many of these signaling proteins interact with the extracellular matrix (ECM), manipulation of the ESC extracellular environment provides a means to direct differentiation. ECM components, such as glycosa

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34

Schötz, Eva-Maria. "Dynamics and Mechanics of Zebrafish Embryonic Tissues." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:swb:14-1191291301268-96071.

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Developmental biologists try to elucidate how it is possible for cells, all originating from the same egg, to develop into a variety of highly specialized structures, such as muscles, skin, brain and limbs. What organizes the behavior of these cells, and how can the information encoded in the DNA account for the observed patterns and developmental processes? Cell movements and tissue flow during embryogenesis constitute a beautiful problem of bridging scales: On the microscopic scale, cells are expressing particular genes which determine their identities and also their fate during morphogenesi

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35

Harding, Heather Darby. "Oct-4 expression in equine embryonic cells." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4793.

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The Oct-4 transcription factor is believed to co-regulate early embryonic development of mammals due to the correlation of its presence with the maintenance of pluripotency. It is commonly used as a marker for the identification of embryonic stem (ES) cells for this reason. Until 1999, Oct-4 studies were limited to in vivo-produced embryos; equine embryos have not been studied for their Oct-4 expression patterns. In addition, equine stem-like cells (defined by marker expression, induced differentiation, passage survival, and morphology) have recently been isolated from in vivo-produced embryos

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36

Joannides, Alexis. "Neural differentiation of human embryonic stem cells." Thesis, University of Cambridge, 2009. https://www.repository.cam.ac.uk/handle/1810/252121.

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Human embryonic stem cells (hESCs) are a potential source of defined cell types for studying early human development and application in regenerative medicine. Realising this potential requires a number of challenges to be overcome. The experimental findings reported represent a systematic approach in establishing controlled and standardised conditions for differentiating hESCs down the neural lineage, and characterising neural derivatives both <i>in vitro</i> and <i>in vivo.</i> Human embryonic stem cell cultures were established from two independently-derived liens, H9 and UES9. A novel, effi

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37

Antonica, Francesco. "Modelling thyroid embryogenesis using embryonic stem cells." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209551.

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Congenital hypothyroidism (CH) is the most frequent of the rare endocrine diseases (e.g. Addison's disease, Cushing's syndrome, Congenital adrenal hyperplasia.), which affects 1:2000 – 4000 newborns. If not immediately diagnosed after birth, thyroid hormones deficiency causes severe defects in brain and skeletal development leading to a complex clinical scenario called cretinism. CH can be due to a defective synthesis of thyroid hormones (dyshormonogenesis) or an abnormal embryonic development of the gland. Data obtained using knockout mouse models have shown the pivotal role of four specific

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38

Gordon-Keylock, Sabrina Anne Megan. "Haematopoietic differentiation of murine embryonic stem cells." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/29123.

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This thesis aimed to determine which subregions of the E10.5 aorta-gonad-mesonephros (AGM) were responsible for the haematopoietic enhancing effects that primary AGM regions had on differentiating ES cells. To this end, a novel co-culture system has been established to test the enhancing effects of a panel of clonal stromal cell lines derived from different subregions of the midgestational AGM. Three stromal cell lines derived from the dorsal aorta and surrounding mesenchyme (AM) subregion of the AGM were able to significantly enhance the frequency of ES cell derived multipotent haematopoietic

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39

Sneesby, Kyra, and n/a. "Gene Expression in Embryonic Chick Heart Development." Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030924.153514.

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Establishment of the biochemical and molecular nature of cardiac development is essential for us to understand the relationship between genetic and morphological aspects of heart formation. The molecular mechanisms that underly heart development are still not clearly defined. To address this issue we have used two approaches to identify genes involved in early chick cardiac development. Differential display previously conducted in our laboratory led to the identification of two gene fragments differentially expressed in the heart that are further described in this thesis. The full-length cDNA

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40

Lake, Julie-anne. "Differentiation of pluripotential murine embryonic stem cells." Adelaide Thesis (Ph.D.) -- University of Adelaide, Department of Biochemistry, 1996. http://hdl.handle.net/2440/18794.

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41

Peeters, Maria Catharina Elisabeth. "Embryonic axial curvature relationships to neuropore closure /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8249.

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42

Dumoulin, Johannes Christianus Marie. "Taurine and preimplantation embryonic development in vitro." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5937.

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43

Both, Sanne Karijn. "Embryonic stem cells in bone tissue engineering." Enschede : University of Twente [Host], 2008. http://doc.utwente.nl/58765.

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44

Pupavac, Mihaela. "Mmachc is required for mouse embryonic development." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104863.

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The cblC form of combined methylmalonic aciduria and homocystinuria (OMIM 277400) is the most frequent inborn error of vitamin B12 (cobalamin, Cbl) metabolism, with over 500 patients identified worldwide. Due to mutations in the MMACHC gene, patients with this disease are unable to convert cobalamin into the two active forms, methylcobalamin and adenosylcobalamin, which are cofactors required by mammalian methionine synthase and methylmalonyl-CoA mutase, respectively. Clinical features of patients can include hematological, neurological, and ophthalmological findings, along with developmenta

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45

Love, Rebecca Margaret. "Improving the survival of embryonic dopaminergic neurons." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343277.

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46

Karunadasa, Delicia Kumari. "Embryonic development of GnRH and vomeronasal neurons." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615881.

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47

Mak, Shiu-kwong Thomas, and 麥肇鑛. "Modeling diabetic cardiomyopathy using embryonic stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193562.

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Diabetic cardiomyopathy (DCM), a disorder of the heart muscle, is one of the major and most rampant culprits claiming thousands and thousands of lives around the globe every year by interfering with the blood circulation and causing the development of heart failure eventually. The progression of the disease is asymptomatic and having a long latent period, and it is characterized functionally by ventricular dilation, diastolic dysfunction, interstitial fibrosis and cardiomyocytes hypertrophy. It was suggested the pathogenesis of the disease and the related complications are related to the effec

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48

Zhang, Xiaoxiao. "Cell Fate Decisions in Early Embryonic Development." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10792.

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The basis of developmental biology lies in the idea of when and how cells decide to divide or to differentiate. Previous studies have established several signaling pathways that determine cell fate decisions, including Notch, Wingless, Hedgehog, Bone morphogenetic protein, and Fibroblast growth factor. Signaling converges on transcriptional factors that regulate gene expression. In mouse embryonic stem cells, I explored how pluripotency and differentiation are regulated through opposing actions of beta-catenin-mediated canonical Wnt signaling, and the mechanisms underlying Sonic hedgehog signa

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49

Henderson, Janet Katharine. "Investigations of human embryonic implantation in vitro." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341905.

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50

Ruangvutilert, Pornpimol. "Genetic analysis of embryonic and fetal tissues." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326239.

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