Journal articles: 'Emblica officinalis linn'

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Patel, Anandkumar M. "A Critical Review of Pandughni Vati." Healer 3, no. 2 (March 19, 2023): 5. http://dx.doi.org/10.51649/healer.135.

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Pandughni Vati(Anubhuta)contains eight Ayurvedic drugs i.e. Amalaki (Emblica officinalis), Bibhitaki (Terminalia bellerica), Shunthi (Zingiber officinale Roscoe.), Maricha (Piper nigrum Linn.) Pippali (Piper longum Linn), Katuki (Picrorhiza kurroa), Punarnava (Boerhavia diffusa Linn.) and Vidanga (Embelia ribes Burm.f.) as well as Bhavana Dravya like Kumari(Aloe vera Miller.), Punarnava (Boerhavia diffusa Linn.), Amalaki (Emblica officinalis) and Gaumutra (Cow’s Urine) as this Formulation Developed by AYUSH Department, Ministry of Health and Family welfare, Govt. of India (Anubhuta). Pandughni Vati(Anubhuta) has properties of Katu-Tikta Rasa, Laghu, Ruksha Guna, Ushna Virya and Katu Vipaka (pungent). The drug has several properties as anti-viral, anti-bacterial, imunomodulatory, hepato protective due to its various components. These properties make it an effective drug for various general and liver diseases.

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S, Tapade S., Punam P. Suryawanshi, Priti Mane, Priyanka Dappadwad, Rameshwar Sangle, Ramraje Lahade, Rutuja Tandle, and Rutuja Bedre. "Pharmacological and Medicinal Important of Plant Phyllanthus Emblica Linn. (Syn.Emblica Officinalis), Indian Gooseberry." International Journal for Research in Applied Science and Engineering Technology 11, no. 10 (October 31, 2023): 1473–80. http://dx.doi.org/10.22214/ijraset.2023.56206.

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Abstract: The plant names phyllanthus emblica linn (Amla) are very precious gift of nature which have a vital role in health care. Nowadays, use of herbal product become most important for humans over the world. This drug is very useful for the treatment of disease. The most important part of this plant (phyllanthus emblica) is fruit. Phyllanthus emblica Linn. (syn. Emblica officinalis), commonly known as Indian gooseberry or amla, belongs to the family Euphorbiaceae. Though all parts of the plant are used for medicinal purposes, the fruits especially are found tremendous pharmacological applications. They are highly nutritious and form an important dietary source of vitamin C, amino acids, and minerals. Emblica Officinalis Plant is reported to have diverse Pharmacological actions like Adaptogenic Activity, Hepatoprotective Activity, Anti-Bacterial Activity, Anti-Hyperlipidemia Activity, Hypolipidemic Activity, Anti-Atherogenic Activity, Immunostimulatory Activity, Anti-oxidant Activity, Anti-Tumor Activity,Anti-Microbial Activity,Chondroprotective Activity, Analgesic Activity, Anti-Inflammatory Activity & AntiDiarreheal Activity. Emblica Officinalis plant is used in the treatments of various ailments. The diverse ailments like cancer, Atherosclerosis, Inflammation, Osteoporosis, Nuerological disorders, Hypertention and other infectious disorders.

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Keserla Bhavani, Gnanavel V, Ratna B, Jayakar B, Aanandan, Natukula Praveen Kumar, Koya Prabhakar Rao, and Namburi Lakshmi Anjaneya Amarbabu. "Comparative evaluation of antiulcer activity of combination of extracts of Embilica officinalis Gaertn and Musa sapientum Linn in rats." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (April 23, 2019): 1535–39. http://dx.doi.org/10.26452/ijrps.v10i2.821.

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The present study is to evaluate the anti-ulcer activity of methanolic extract of unripe fruits of Musa Sapientum Linn. and the fresh juice of the fruits of Emblica Officinalis Gaertn in Wistar rats. The methanolic extract unripened fruits of Musa Sapientum Linn. and the fresh juice of the fruits of Emblica Officinalis Gaertn were combined and evaluated for the gastroprotective activity by ethanol-induced model and indomethacin-induced model in rats at a dose of 25mg/kg (p.o) and 50mg/kg (p.o) respectively. Biochemical parameters like ulcer index, the volume of gastric juice, pH of gastric juice, free acidity and total acidity were studied. The unripe fruits of Musa and the fresh juice of Embilica will contain flavonoids, flavones, abscisic acid which shows a significant reduction in gastric volume, pH, free acidity, total acidity and ulcer index at the doses of 25mg/kg (p.o) and 50mg/kg (p.o). The results show that the unripe fruits 0f Musa Sapientum Linn. and fresh juice from the fruits of Emblica Officinalis Gaertn will combinedly possess greater antiulcer activity than that of the individual drugs.

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Mansoury, Manal. "A Review of the Antidiabetic, Antihyperlipidemic, and Related Metabolic Disorder Documented Activities of Emblic Fruits (Phyllanthus emblica L.)." Journal of Complementary Medicine Research 14, no. 1 (2022): 1. http://dx.doi.org/10.5455/jcmr.2022.13.05.01.

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Diabetes is a risky metabolic chronic sickness that threatens the lives and health of individuals, families, and communities everywhere. Management of diabetes and related metabolic syndrome (MS) relies heavily on diet. There are reports of folk plants showing varying levels of antihyperglycemic activity. Phyllanthus emblica Linn (syn. Emblica officinalis) (often referred to Emblic, Indian gooseberry, or amla) is a perennial tree in the Euphorbiaceae family. Due to the high concentration of phenolic compounds, Emblic fruit may be considered a plant source of natural antioxidants. Numerous studies have demonstrated Emblic fruit’s benefits on humans and animals that are antihyperglycemic, anti-inflammatory, antihyperlipidemic, antibacterial, analgesic and antipyretic, adaptogenic, hepatoprotective, anticancer, antiulcerogenic, and antioxidant. This review provided an overview of the published scientific studies (experimental and clinical) that documented the potential antidiabetic and antihyperlipidemic benefits associated with consuming Emblic fruits. In addition, the possible activity regarding related metabolic syndrome and diabetes complications was assessed.

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Deshmukh, Chinmay Devidas. "PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF EMBLICA OFFICINALIS LINN." Journal of Medical pharmaceutical and allied sciences 10, no. 2 (May 15, 2021): 2698–703. http://dx.doi.org/10.22270/jmpas.v10i2.1054.

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Emblica officinalis (EO) (Family: Euphorbiaceae) , commonly called Amla, is a traditional plant, occurring commonly in deciduous forests in India and widely used globally for the management of various ailments. When its phytochemistry is studied in detail, it reveals the presence of vitamin C, ellagic acid, gallic acid, phyllemblin, tannin, phyllemblic acid, lipids and emblicol. The fruit of this plant is commonly used for a cooling, diuretic, laxative activity. It is also used for the treatment of anemia, jaundice and dyspepsia. The seeds are used for the management of different respiratory tract disorders such as bronchitis, asthma, and digestive problems. Various scientists and researchers have isolated the parts of this plant for studying its pharmacological activities and therapeutic approaches. They have explored this plant for its hepatoprotective, gastroprotective, cytoprotective, antitumor, antifungal and antiulcer activity. Further, this plant is also claimed to have other beneficial effects in Ayurveda and traditional medicines. This plant is common and widely available. It is consumed by various Indian people routinely. It is important ingredient of cosmetics, shampoos, hair oils, dyes and famous health tonic Chyavanprash. Though, various literature is available on this plant and fruit but due to interest and curiosity to further explore the information of its uses, chemical composition, pharmacological activities of extract and its isolated compounds and safety profile, the present review paper is planned. This information will be useful for further research of this plant.

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Sarkhel, S., A. K. Chakravarty, R. Das, Aparna Gomes, and A. Gomes. "Snake venom neutralising factor from the root extract of Emblica officinalis Linn." Oriental Pharmacy & Experimental Medicine 11, no. 1 (February 23, 2011): 25–33. http://dx.doi.org/10.1007/s13596-011-0008-4.

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Kannan, Amulya, Kavya N, Niveditha BM, Monica KP, and Sulochana Bhat. "A CASE STUDY ON AMALAKI SVARASA (PHYLLANTHUS EMBLICA): A POTENTIAL SINGLE DRUG INTERVENTION IN MANAGEMENT OF PRAMEHA (DIABETES MELLITUS)." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (August 30, 2022): 1–4. http://dx.doi.org/10.7897/2277-4343.130475.

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Diabetes is becoming a major health problem, approaching epidemic proportions. Rich medicinal plants have been recognized and documented in Ayurveda texts in the management of prameha (Diabetes mellitus); one among the most appreciated is Amalaki - Indian gooseberry or Amla, also known as Phyllanthus emblica Linn. (Syn. Emblica officinalis Gaertn.), belonging to the family Euphorbiaceae. Amalaki svarasa (juice of amla) was given for one month to a diabetic patient with high glucose levels and exhibited significant results in decreasing blood glucose levels and significant relief in symptoms like fatigue, burning sensation in feet, giddiness, headache, pain below the knees and excessive thirst. Fasting Blood Sugar before treatment was 375 mg/dl and 281 mg/dl after treatment. Postprandial Blood Sugar was 535 mg/dl and 382 mg/dl after treatment. Though several pharmacological studies and few clinical studies have already been done regarding diabetes prevention with this drug, there is still enough scope for re-validating its therapeutic application with its authentic Ayurveda indications and comprehensions.

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Singh, Inder, Dhanraj Soyal, and Pradeep Kumar Goyal. "Emblica officinalis (Linn.) Fruit Extract Provides Protection against Radiation-Induced Hematological and Biochemical Alterations in Mice." Journal of Environmental Pathology, Toxicology and Oncology 25, no. 4 (2006): 643–54. http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.v25.i4.40.

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Vaidya, Vinit, Vedaant Bhandary, Faisal Qureshi, Priyanshi Vishwakarma, and Tonica Dubey. "Estimation of Amount of Vitamin-C in Various Products of Amla (Emblica officinalis Linn.) and Lemon (Citrus limon Linn.) to be Consumed as a Natural Immunity Booster." International Journal of Science and Research (IJSR) 11, no. 8 (August 5, 2022): 1120–23. http://dx.doi.org/10.21275/sr22819100238.

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Rekha Raja, Nirubama Kumar, and Moorthy Duraisamy. "Ethnomedicinal plants used by malayali tribals in yercaud hills, salem district, tamil nadu, india." Kongunadu Research Journal 9, no. 1 (June 30, 2022): 9–21. http://dx.doi.org/10.26524/krj.2022.2.

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The present study highlights the importance of some medicinal plants in the health care system of Malayali tribal community of Yercaud Hills, Salem district, Tamil Nadu, India. Ethnomedicinal information was collected from malayali tribes through personal interviews and group discussions with 8 randomly selected informants. Use value (UV), fidelity level (FL) and Informant Consensus factor (ICF) were determined. During the data collection 20 species distributed in 16 families for treating 44 different ailments. Ethnomedicinal plants like Abrus pulchellus, Wall, Andrographis paniculata, Wall.ex.Nees, Asclepias curassavica, L, Asparagus racemosus, Wild, Azadirachta indica, A. Juss, Cassia fistula, Linn, Centella asiatica, Urb, Corallocarpus epigaeus, Hook.f, Curculigo orchioides, Gaertn, Emblica officinalis, Gaerth,Enicostemma littirale, Blume, Hemidesmus indicus, R. Br, Holarrhena pubescens (Buch.Ham.) Wall.ex.G.Don, Leucas aspera, Spreng, Mimosa pudica, Linn, Myrica esculenta, Buch. Ham, Pergularia daemia (Forsk.) chiov, Terminalia bellerica, Roxb, Terminalia chebula, Retz and Toddalia asiatica, Lamk were documented during the study. UV of the encountered plant species ranged from 0.38 to 1.13. The uppermost FCI value is reported for Ejaculation of semen and Bone fracture. In the present investigation, the FL varied from 50 to 100%.

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Rawat, Neelam, Yadevendra Yadav, Shuchi Mitra, Usha Sharma, and Khem Chand Sharma. "ANTI-INFLAMMATORY AND ANTI-MICROBIAL ACTION OF TRIPHALA GUGGULU: A REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (August 30, 2022): 121–30. http://dx.doi.org/10.7897/2277-4343.1304101.

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Triphala Guggulu, an Ayurvedic herbal formulation, consists of dried powder of fruits of three plants commonly known as Triphala: Emblica officinalis Gaertn. (Euphorbiaceae), Terminalia bellerica Roxb. (Combretaceae) and Terminalia chebula Retz. (Combretaceae) along with Piper longum Linn. (Piperaceae), combined with the oleo-gum resin of Commiphora wightii Arnott. Bhandari (Burseraceae). It is mentioned in the Ayurvedic Formulary of India (AFI) taken from Sharngadhar Samhita for several therapeutic uses. This formulation is indicated in the treatment of Bhagandara (fissure-in-ano), Gulma (Benign growths), Shotha (Inflammation) and Arsha (Piles) by Acharya Sharangdhara Mishra in his book. This review article aims to evaluate all the experimental work done on the anti-inflammatory and anti-microbial action of constituents of Triphala Guggulu. A review of all research work was done from the Central Council of Research in Ayurvedic Sciences (CCRAS) database of medicinal plants and online research journals. The outcome of this study shows that all Triphala Guggulu ingredients can work as anti-inflammatory and antibacterial activity against a wide range of microbes. Thus, Triphala Guggulu is an effective formulation to cure infectious wounds and normalize gut motility, beneficial in health conditions such as Piles, Fistula, Inflammation etc.

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S, Balavenkata Krishna, and Sitaram Bulusu. "Critical study of Pramehahara effect of Dhaatri Nishe w.s.r. to Diabetes mellitus." International Journal of Ayurvedic Medicine 9, no. 3 (October 4, 2018): 196–201. http://dx.doi.org/10.47552/ijam.v9i3.1127.

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Nishaamlaki is a known Ayurvedic medicinal preparation which is found effective in controlling the Diabetes mellitus. But according to Astanga hridaya “Meheshudhaatrinishe” combination of Aamlaki and two Haridra drugs effectively controls Prameha.Here the word “NISHE” indicates two drugs i.e., Haridra and Daruharidra.The combination of Aamlaki (Emblica officinalis Linn.) Haridra (Curcuma longa Linn.) and Daruharidra (Berberis aristata D.C & Coscinium fenestratum Colebr.) is to be considered as “Srestha” (Drug of choice) in Diabetes mellitus. India leads the world’s largest number of diabetic subjects earning the dubious distinction of being termed the diabetes capital of the world. According to diabetes atlas 2008 published by Indian diabetic federation, the number of people with diabetes in India are currently around 40.9 million and is expected to rise to 69.9 million by 2025 unless urgent preventive measures are taken. In India, it is also 3rd leading cause of death (After heart disease and cancer).It has turned out to be the biggest “silent killer” in today’s world. The present research work is done on 60 patients dividing them into 2 groups.DH1 Group was given with Aamalaki, Haridra and Daruharidra {Berberis aristata D.C}, DH2 Group was given with Aamalaki, Haridra and Daruharidra {Coscinium fenestratum Colebr.}. Finally it is concluded that Daruharidra which is known botanically as Berberis aristata D.C is highly effective in controlling the blood sugar levels in combination with Aamalaki and Haridra than Coscinium fenestratum Colebr. in combinations with Aamalaki and Haridra.

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Tejaswini, Tumma, and Ch Sridurga. "Pharmaceutical Standardization of Mayaphaladi Churna." Journal of Drug Delivery and Therapeutics 9, no. 6 (November 15, 2019): 64–69. http://dx.doi.org/10.22270/jddt.v9i6.3644.

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Rasa Shastra is the pharmaceutical branch of Ayurveda. As like any other medical system, success of Ayurvedic treatment also depends upon quality of medicine prescribed to the patient. The integral part of Rasa Shastra lies in the successful pharmaceutical process. Rasa oushadis are the potent Ayurvedic preparations mainly containing metals and minerals. These oushadis possess a wide range of therapeutic efficacy and are considered superior because of their qualities like small dose, quick action, palatability and longer shelf life. Mayaphaladi Churna is an important Rasa oushadi described in Rasa Tantra Sara Va Siddha Prayoga Sangraha- Part 2, Streerogadhikara indicated for the management of the diseases Swetapradara and Yonibramsha. The ingredients present in the ‘Mayaphaladi Churna’ are Kukkutanda twak bhasma (Egg Shell Ash), Shuddha Sphatika (Alum), Mayaphala Churna (Quercus Infectoria Oliv.), Amalaki Churna (Emblica Officinalis Gearth), Ashwagandha Churna (Withania Somnifera Linn.) and Sita Churna (Sugar Candy). The main pharmaceutical procedures involved in the preparation of Mayaphaladi Churna are Shodhana, Marana, Churna nirmana and preparation of Mayaphaladi Churna. The specific pharmaceutical blend of these contents can result in a more effective formulation. Therefore the present study has been planned to standardize the method of preparation of Mayaphaladi Churna according to the method explained in the classical literatures. Keywords: Mayaphaladi Churna, Shodhana, Marana, Churna Nirmana, Standardization.

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Masal, Aishwarya, and Arati Shinde. "Management of Herpes Zoster solely employing Ayurveda: A case report." International Journal of Ayurvedic Medicine 14, no. 4 (January 7, 2024): 1127–32. http://dx.doi.org/10.47552/ijam.v14i4.3909.

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Background: Varicella-zoster virus (VZV) causes two distinct clinical syndromes: varicella (chickenpox) and herpes zoster. Though human-specific, varicella-zoster virus infections can last for a few hours or even a day or two outside of humans. Herpes zoster is similar to Visarpa disease in Ayurvedic texts. Visarpa spreads very rapidly to many different body parts. Because it spreads throughout the body, it is also known as Parisarpa. Analysing the herpes zoster symptoms, it reveals vitiating Twak, Rakta, and Mamsa Dhatu, with vitiation of Vata-Pitta-dominated Tridosha. This helps us understand the gravity and importance of the disease. Visarpa is not a chronic illness like Kushtha (skin diseases), but, if left untreated, might lead to severe complications. Material and methods: A 25-year-old female with the main complaint of gradually erupted vesicles on the ventral aspect of her right forearm and excruciating burning pain, erythema, and mild itching. The patient was treated with Patolakaturohinyadi Kashayam, powders of Sariwa (Hemidesmus indicus R.Br.), Yashtimadhu (Glycyrrhiza glabra Linn.), Amalaki (Emblica officinalis Gaertn.), Gandhaka rasayana. Shatadhauta ghrita and Durva ghrita were used for local application. Observation and Result: With the aid of internal treatment employing these yogas, the patient shown optimistic outcomes, and herpes zoster was successfully treated with Ayurveda.

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Quamar, M. F., and M. S. Chauhan. "Modern pollen assemblages from teak (Tectona grandis Linn. F.) dominated tropical deciduous forest in southwestern Madhya Pradesh, India." Journal of Palaeosciences 62, no. (1-2) (December 31, 2013): 29–37. http://dx.doi.org/10.54991/jop.2013.333.

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This paper gives an account on the modern pollen rain–vegetation relationships, based on the pollen analysis of 12 surface samples, 2 samples each collected from the southern, northern, eastern and western flanks of Amjhera Swamp as well as 4 from the mixed tropical deciduous forests dominated by teak (Tectona grandis) in Hoshangabad District, southwestern Madhya Pradesh, India. The pollen assemblages demonstrate the dominance of arboreals (trees and shrubs) over non–arboreals (herbs). Among the tree taxa, Madhuca indica is constantly represented with average pollen frequency of 37.36% in most of the samples which could be attributed to the good preservation of its pollen in the sediments coupled with its high pollen dispersal efficiency. Terminalia (av. 5.1%) is also retrieved steadily. However, Tectona grandis is untraced in the samples despite being an enormous pollen producer and dominant forest component, which could be due to its low pollen dispersal efficiency and differential pollen preservation. Besides, Adina cordifolia, Mitragyna parvifolia, Schleichera oleosa and Emblica officinalis are present with average pollen frequencies of 8.1%, 7.8%, 6.69% and 1.126%, respectively, but only in a few samples. Syzygium, Maytenus, Lagerstroemia, Lannea coromandelica, etc. are also intermittently recovered in almost all the samples, but in varying frequencies (< 0.5%–7.91%) despite their frequent presence in the forest. This erratic display of all these taxa could be inferred to their low pollen productivity, since majority of the tropical trees portray a strong tendency of entomophily. The partial preservation of their pollen in the sediments cannot also be denied. The relatively meagre representation of grasses, sedges, Malvaceae, Xanthium except Tubuliflorae and culture pollen taxa such as Cheno/Am, Caryophyllaceae, Brassicaceae and Cannabis sativa are suggestive of poor herbaceous cover around the swamp and also in the mixed tropical deciduous forest. However, the record of Cerealia and other culture pollen taxa stamps the proximity of cultivated land and human habitation in and around the investigation site. The abundance of trilete fern spore as well as Ceratopteris, monolete fern spore and trilete with perine, though in relatively low values envisages their origin from the local sources as ferns and their allies flourish well in moist and shady habitats.

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Murugesan, Selvakumar, Sanjay Kottekad, Inchara Crasta, Sivakumar Sreevathsan, Dandamudi Usharani, Madan Kumar Perumal, and Sandeep Narayan Mudliar. "Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study." Computers in Biology and Medicine 136 (September 2021): 104683. http://dx.doi.org/10.1016/j.compbiomed.2021.104683.

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Elumalai, Nandhakumar, Purushothaman Ayyakkannu, Shanthi Palanivelu, and Sachdanandam Panchanadham. "In vitro antioxidant potential of Shemamruthaa (a herbal formulation) and its anticancer activity in the MCF-7 cell line." RSC Advances 5, no. 30 (2015): 23125–33. http://dx.doi.org/10.1039/c4ra12346h.

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The current study investigates the free radical scavenging activities of methanolic and aqueous extracts of Shemamruthaa (Hibiscus rosa sinensis, Emblica officinalis and honey in definite ratio) and their anticancer activity in the breast cancer (MCF-7) cell line ex vivo.

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Nisar, Akib, Mayur Aswani, Sara Kamyab, Alpana Moghe, and Abhay Harsulkar. "Isolation of prebiotics from wild vegetables: In vitro characterization by antioxidant assays and human adenocarcinoma cell line (HT-29)." Research Journal of Biotechnology 17, no. 12 (November 25, 2022): 29–40. http://dx.doi.org/10.25303/1712rjbt29040.

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Wild vegetables are recognized for their antioxidants, fibres, other bioactive components and consumed as a rich prebiotic source along with probiotics. Crude prebiotics were isolated from wild vegetables and extracts were treated with digestive enzymes to enrich non-digestible prebiotics. The prebiotics were used to prepare different synbiotic formulations with Lactobacillus plantarum strains, L. bulgaricus and L. lactis whereas inulin served as a positive control. These formulations were evaluated for antioxidant activities viz. lipopolysaccharide-induced cell survival assessment and microbial cell adhesion using the HT-29 cell line. All formulations showed significant antioxidant activity. L. plantarum, L. plantarum (LB-VII) and L. bulgaricus with prebiotic Emblica officinalis showed highest DPPH radical scavenging activity (≈85%). ABTS radical scavenging activity was maximum for L. plantarum (LB-VII) with E. officinalis (57%). L. bulgaricus with E. officinalis showed highest FRAP activity (≈515 μM). Cell survival was restored in presence of prebiotics and maximum was observed in L. plantarum (LB-VII) with E. officinalis (77.8%) and the highest microbial cell adhesion was 76% of L. bulgaricus with E. officinalis. Microscopic cell adhesion assay showed successful adhesion to mucus secreted by HT-29 cells. This study underlines and provides evidence for the usage of wild vegetables as a source of prebiotics.

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Mishra, SunilS, ShrutikaR Sonawane, HarshwardhanB Sawane, AnitaD Munde, Aarati Panchbhai, and SantoshkumarP Mastud. "Antiproliferative effects of Emblica officinalis and metformin on oral cancer cell line: An In vitro study." Journal of Indian Academy of Oral Medicine and Radiology 35, no. 2 (2023): 156. http://dx.doi.org/10.4103/jiaomr.jiaomr_16_23.

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Somasekhar, Vanita, Purnima Ashok, Sri Adibatla Renuka Kameswari, Ramaswamy Rajendran, and Rajpreet Singh. "Comparative antioxidant and bioavailability studies of Vitamin C in Phyllanthus emblica Linn. and its combinations with Piper nigrum Linn. and Zingiber officinale Roscoe." Brazilian Journal of Pharmaceutical Sciences 52, no. 1 (March 2016): 35–43. http://dx.doi.org/10.1590/s1984-82502016000100005.

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ABSTRACT Phyllanthus emblica Linn. (amla) is used in Ayurveda, the ancient Indian system of medicine and its major constituent is vitamin C which has effective free radical scavenging property. The purpose of this study was to evaluate the in vitro antioxidant activity and the bioavailability profile of vitamin C in amla and its combinations with piperine and ginger in comparison to synthetic vitamin C using New Zealand rabbits. In vitro antioxidant activity studies of synthetic vitamin C, amla, amla with piperine and amla with ginger were carried out using different models such as 2,2-Diphenyl-1-picrylhydrazyl, Nitric Oxide, Hydrogen peroxide scavenging methods, Total reductive capability and Oxygen Radical Absorbance Capacity estimation. The study results showed that synthetic vitamin C, amla, amla with piperine and amla with ginger possess significant in vitro antioxidant activity. For bioavailability studies, synthetic vitamin C, amla, amla with piperine and amla with ginger 100 mg/kg, were administered orally and the serum samples were analyzed by HPLC at 0, 1, 2, 3, 4, 6, 8, 10, 12 and 24 hours. Bioavailability studies revealed that amla with piperine combination has higher concentration of vitamin C when compared to synthetic vitamin C. This is probably due to presence of piperine, which is a bioavailability enhancer. The present study supports the fact that amla with piperine combination can be an alternative to synthetic vitamin C.

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Kumari, Shiwani, Ambica Singh, Abhinay Kumar Singh, Yudhishthir Yadav, Swati Bajpai, Pramod Kumar, Ashish Datt Upadhyay, et al. "Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer’s Disease." Journal of Alzheimer's Disease 85, no. 1 (January 4, 2022): 249–60. http://dx.doi.org/10.3233/jad-215347.

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Background: Alzheimer’s disease (AD) is the progressive brain disorder which degenerates brain cells connection and causes memory loss. Although AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. However, this would only be possible if the disease is diagnosed at an early stage, and early diagnosis requires clear understanding of the pathogenesis at molecular level. Overactivity of GSK-3β and p53 accounts for tau hyperphosphorylation and the formation of amyloid-β plaques. Objective: Here, we explored GSK-3β and p53 as blood-based biomarkers for early detection of AD. Methods: The levels of GSK-3β, p53, and their phosphorylated states were measured using surface plasmon resonance and verified using western blot in serum from AD, mild cognitive impairment (MCI), and geriatric-control (GC) subjects. The neurotoxic SH-SY5Y cell line was treated with antioxidant Emblica Officinalis (EO) for rescue effect. Results: GSK-3β, p53, and their phosphorylated states were significantly over expressed (p > 0.001) in AD and MCI compared to GC and can differentiate AD and MCI from GC. The expression level of GSK-3β and p53 proteins were found to be downregulated in a dose-dependent manner after the treatment with EO in amyloid-b-induced neurotoxic cells. Conclusion: These proteins can serve as potential blood markers for the diagnosis of AD and EO can suppress their level. This work has translational value and clinical utility in the future.

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Niyomchan, Apichaya, Wasapon Chatgat, Bodin Chatawatee, Thaweeporn Keereekoch, Patcharawalai Jaisamut, Sasitorn Chusri, and Nongluk Kunworarath. "Supplementation with the Traditional Thai Polyherbal Medicine NawaTab Ameliorates Lipid Profiles in High-Fat Diet-Induced Hyperlipidemic Rats." Evidence-Based Complementary and Alternative Medicine 2022 (November 21, 2022): 1–11. http://dx.doi.org/10.1155/2022/8574756.

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A tablet formulation developed from Nawametho decoction (NawaTab), a traditional Thai herbal mixture described in the Worayokasan scripture, has been used clinically for several years in the management of borderline hyperlipidemic individuals. Nevertheless, scientific evidence supporting its claims has never been identified. This study aimed to describe the antihyperlipidemic properties of NawaTab in a well-described model of high-fat diet (HFD)-induced hyperlipidemic rats. Decoction of Nawametho containing equal quantities of Aegle marmelos (L.), Carthamus tinctorius L., Hibiscus sabdariffa Linn., Phyllanthus emblica L., Piper longum L., Piper nigrum L., Terminalia bellirica (Gaertn.) Roxb., Terminalia chebula Retz., and Zingiber officinale Roscoe were prepared. The HFD-fed rats were administered NawaTab for 4 consecutive weeks starting from the ninth week of HFD treatment at a dose of 125 mg/kg (p.o.). Anthropometric parameters, serum lipid profiles, lipase activity, and liver and renal functional markers were measured. Histopathological examination of the liver and any steatosis was carried out at the end of this study. Consecutive treatment with NawaTab (125 mg/kg/day) in HFD-induced hyperlipidemic rats caused a significant reduction in serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels. However, at the tested dose, NawaTab failed to prevent the onset of hepatic steatosis and adipose tissue accumulation. No adverse events due to the consumption of NawaTab on liver and kidney function markers were noted. These findings are the first suggestive evidence for the lipid-lowering capability of NawaTab. However, to promote the use of this formulation in the management of borderline hyperlipidemic patients, elucidation of the underlying mechanisms of action, quantification of biological markers, and clinical trials of NawaTab are urgently needed.

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Jaisamut, Patcharawalai, Channong Tohlang, Subhaphorn Wanna, Acharaporn Thanakun, Thawatchai Srisuwan, Surasak Limsuwan, Wissava Rattanachai, Jarinee Suwannachot, and Sasitorn Chusri. "Clinical Evaluation of a Novel Tablet Formulation of Traditional Thai Polyherbal Medicine Named Nawametho in Comparison with Its Decoction in the Treatment of Hyperlipidemia." Evidence-Based Complementary and Alternative Medicine 2022 (August 3, 2022): 1–10. http://dx.doi.org/10.1155/2022/2530266.

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In the traditional medical system in Thailand, medicinal plants and polyherbal medicines have been prescribed as lipid-lowering agents, including Nawametho decoction. This polyherbal formulation is described in the Worayokasan scripture. It consists of nine medicinal plants (Aegle marmelos (L.), Carthamus tinctorius L., Hibiscus sabdariffa Linn., Phyllanthus emblica L., Piper longum L., Piper nigrum L., Terminalia bellirica (Gaertn.) Roxb., Terminalia chebula Retz., and Zingiber officinale Roscoe). Apart from its utilization in Thai traditional medicine, there is a lack of evidence supporting its use. This research work thereby aims to formulate and evaluate the tablet containing Nawametho decoction. The feasibility of Nawametho decoction and NawaTab for patients with borderline hyperlipidemia was additionally examined using a prospective, open-label, randomized, parallel-group design. The dry granulation technique was employed to formulate the polyherbal tablets. The tablets were developed using the spray-dried Nawametho decoction as the active ingredient in addition to other excipients. The chosen formulation, the FB (NawaTab), consisted of 385 milligrams of the extract, 12% w/w of a diluent (lactose), 8% w/w of a lubricant (magnesium stearate), 5% w/w of a disintegrant (microcrystalline cellulose), and 5% w/w of an anti-adherent (talcum). Their hardness, friability, and disintegration time were 4.4 ± 0.32 kg, 0.05 ± 0.02%, and 4.60 ± 0.05 min, respectively. Accelerated stability study results revealed that NawaTab was stable for six months at 40°C/75% RH and 25°C/60% RH. Even though taking NawaTabs (500 mg twice daily) for eight consecutive weeks was unable to improve the lipid profile of the patients, the administration of Nawametho decoction (30 mL twice daily) was associated with a significant decrease in serum triglycerides of the patients. The results show that the dry granulation technique is suitable for the formulation of NawaTab based on the tablet evaluation. Furthermore, the triglyceride-lowering effect of Nawametho decoction was reported for the first time.

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Rani, Sheenam, Usha Sharma, Sanjay Kumar Singh, and Khem Chand Sharma. "A REVIEW ON PALITYA AND DHATRYADI RASAYANA." International Journal of Research in Ayurveda and Pharmacy, June 30, 2023, 95–99. http://dx.doi.org/10.7897/2277-4343.140390.

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Hair is a valuable anatomical structure of the body, having cosmetological and sociological importance in drafting the beauty and personality of an individual. Greying of hair represents the sign of ageing known as Palitya in Ayurveda. But when hair starts greying before the usual age of onset, known as premature greying of hair. Premature hair greying is called Akalaja Palitya, which occurs due to various factors resulting in the vitiation of Pitta dosha. Due to mankind’s hectic, sedentary and busy schedule, the current scenario is witnessing several challenges, and premature greying of hair is one among them. Premature hair greying has multifactorial aetiology, including oxidative stress, nutritional deficiency, smoking, and dysfunctional thyroid hormones, but the exact aetiology is still unknown. Acharyas have mentioned various rasayana for preventing and treating premature hair greying, i.e., Akalaja Palitya. Rasayana therapy aims primarily to promote the strength and vitality of the body. It also helps maintain the integrity of sapta dhatus (fundamental structural component) by improving digestive power resulting in the sound production of successive dhatus and their malas. Dhatryadi rasayana is a polyherbal formulation consisting of three ingredients, i.e., Dhatri (Emblica officinalis Gaertn.), Bhringraj (Eclipta alba Hassk.) and Tila (Sesamum indicum Linn.). All three plants have the keshya property. Emblica officinalis Gaertn. and Sesamum indicum Linn. both act as a 5α-reductase inhibitor. Eclipta alba Hassk. stimulates the proliferation of follicular keratinocytes by downregulating the TGF-β1 (Transforming Growth Factor Beta 1) expression. Furthermore, all ingredients of Dhatryadi rasayana have antioxidant properties and contribute to essential nutritional supplements required for proper hair development and growth.

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Swathi, V., J. N. Suresh Kumar, P. Dharani Prasad, Syed Salma, M. Rani, Sk Azam Aslam, and K. Tipsy. "A Review on Phyllanthus emblica: Anti-inflamatory and Antioxidant Effect." UTTAR PRADESH JOURNAL OF ZOOLOGY, April 18, 2023, 23–32. http://dx.doi.org/10.56557/upjoz/2023/v44i63451.

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Phyllanthus emblica L. (amla) managed in Ayurveda as potent rasayan in treating hepatic disorders. Phyllanthus emblica Linn (Emblica officinalis Gaertn) widely reputed as Amla or Indian Gooseberry a well-known tree used in production of herbal pharmacological medicines. A highly nutritious plant reported with dietary source of vitamin C, Minerals and amino acids. This plant is of superior value in Medicine, Ayurveda. Amla fruits are widely employed in treatment of diarrhea, jaundice and inflammation. The plant has proven its efficiency in treating antidiabetic, hypolipidemic, antibacterial, antioxidant, spasmolytic, antiulcerogenic, hepatoprotective, gastroprotective and chemoprotective property. All the parts of plants are rich in medicinal value. The plant consists of various phytoconstituents like alkaloids, phenols, tannins, minerals, vitamins, amino acids, fixed oils, multi vitamins and inorganic compounds. Organic chemicals like Ellagic acid, Gallic acid, Emblicanin A & B, Phyllembein, Quercetin and Ascorbic acid are decided to be efficient for health. The various other Ayurvedic potentials of P. emblica are yet to be proven scientifically in order to explore its broad spectrum of therapeutic effects. In the current review, the conventional Amla use for household treatment in indigenous people and its activities will be of tremendous potential and importance. Therefore, an effort has been made to increase knowledge of the medical importance and use of Amla as a rich natural source of novel bioactive components.

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Baliga, Manjeshwar S. Shrinath, Vijaya Marakala, Raymond Anthony, and Thomas George. "Fruits of Emblica officinalis Linn. and its Phytochemicals in the Prevention of Ethanol-induced Hepatotoxicity: A Mini-Review." Letters in Functional Foods 01 (January 22, 2024). http://dx.doi.org/10.2174/0126669390257953231101111549.

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Excessive alcohol consumption over time is one of the primary causes of liver disease and death globally. Because there is no effective treatment, the situation has become more complicated, and the emphasis has shifted to the use of alternative and complementary medicine to treat liver problems. Herbs with dietary use have played an important part in the treatment of liver diseases since antiquity. Amla or Indian gooseberry, scientifically known as Phyllanthus emblica or Emblica officinalis, is a fruiting plant of the Phyllanthaceae family that is used in a variety of traditional and folk medical systems. The fruits have both dietary and medicinal value and are used to prevent chemical-induced hepatocarcinogenesis and reduce experimentally induced hyperlipidemia and metabolic syndrome in laboratory animals. They also have hepatoprotective effects against a variety of hepatotoxins such as heavy metals, iron overload, ochratoxins, hexachlorocyclohexane, carbon tetrachloride, therapeutic drugs such as paracetamol, and antitubercular. Amla fruits and phytochemicals such as quercetin, gallic acid, ellagic acid, and kaempferol are known to reduce ethanol-induced liver damage, and mechanistic studies have shown that the beneficial effects of these phytochemicals are mediated in part by free radical scavenging, antioxidant, and anti-inflammatory effects. This review examines the positive effects of amla fruit and its phytochemicals for the first time, as well as the mechanisms underlying the protective effects.

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"Amla and Its Nutritional Properties: A Review." Issue 4, Volume 5 (October 3, 2020): 67–69. http://dx.doi.org/10.46243/jst.2020.v5.i6.pp67-69.

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: Emblica phyllanthus Linn. or Gaertn Emblica officinalis one of the most important medicinal plants in Indian traditional systems of medicine (Ayurveda, Unani and Siddha). It is commonly known as Indian gooseberry or Amla. It is a well-known fact that all components of amla are effective in the treatment of different diseases. Of everything, fruit is the most essential element. In the Indian system of medicine, Amla fruit is commonly used as a diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, anti-pyretic, hair tonic, and preventive for ulcers and common cold, fever; as alone or in combination with other herbs. Major chemical constituents, including tannins, alkaloids, polyphenols, vitamins and minerals, were revealed in phytochemical studies on amla. Biological potency is found in gallic acid, ellagic acid, emblicanin A&B, phyllembein, quercetin and ascorbic acid. Amla studies show its analgesic, anti-tussive, antiatherogenic, adaptogenic, cardio, gastro, nephro and neuroprotective, chemopreventive, modulatory and anticancer radio and chemotherapy properties. Amla is also reported to have powerful free radical scavenging activities that are efficient in the prevention and treatment of various diseases such as cancer, atherosclerosis, antioxidant, anti-inflammatory, anti-mutagenic, immunomodulatory, Diabetes, illnesses of the liver and heart. This article provides some information about amla and its nutritional properties.

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Barik, Braja Sundar, Shritam Das, and Tahziba Hussain. "Pharmacognostic Properties of Quisqualis indica Linn: Against Human Pathogenic Microorganisms: An Insight Review." European Journal of Medicinal Plants, December 31, 2020, 87–103. http://dx.doi.org/10.9734/ejmp/2020/v31i2030369.

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India has a large repository of medicinal plants that are used in traditional medical treatments. Several medicinal plants are useful for treating common ailments and some of the plants include Amla (Emblica cinalis), Ashoka (Saraca asoca), Aswagandha (Withania somnifera), Tulsi (Ocimum sanctum), Sarpa Gandha (Rauwolfia serpentina), Sandalwood (Santalum album), Indian birthwort (Aristolochia indica L.), Brahmi (Bacopa monnieri), Neem (Azardirchata indica), Vringraj (Eclipta alba), Grhit kumara (Aloe vera), Harida (Terminalia chebula) and Madhumalati (Quisqualis indica), Catnip (Nepeta cataria), Cayenne pepper (Capsicum annuum), Sage (Salvia officinalis); etc. Quisquails indica commonly known as the Madhu Malati, is a vine with red flower clusters and is found in abundance in India. It shows a wide range of remarkable medicinal properties. Over the last two decades, large scale research has been conducted to identify bio-active constituents of Quisqualis indica therapeutic prospects. This review summarizes the pharmacognostic properties of Quisqualis indica Linn. Against human pathogenic microorganisms. Several authors have reviewed the medicinal properties of Quisqualis indica Linn.but our review summarizes the anti-bacterial, anti-inflammatory, anti-oxidant, anti-pyretic, anti-helminthic, anti-diarrheal, anti-hyperglycemic, anti-microbial, anti-fungal and immuno-modulatory properties. It would be useful to students, academicians, microbiologists, as it reduces the need for detailed searching. It serves the purpose of quick reference.

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Minakshi Paneru and Nisha Ojha. "Immune-Enhancing Effect of an Ayurveda formulation Vidhara-Amalaki Yog." International Journal of Ayurveda and Pharma Research, December 31, 2023, 64–71. http://dx.doi.org/10.47070/ijapr.v11i12.3036.

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Plant extracts and Ayurvedic polyherbal mixtures have been used to treat a variety of diseases since time immemorial. Studies on the therapeutic effects of these extracts in the treatment of various disorders are also extensively established. The synergistic effect of polyherbal medications in repairing and revitalizing the immune system is also highlighted in Ayurvedic classics. Argyreia speciosa Linn. (Elephant Creeper, Vidhara in Sanskrit; Family: Convolvulaceae) and Emblica officinalis Gaertn (Indian gooseberry, Amalaki in Sanskrit; Family: Phyllanthaceae) are important drugs explained in Ayurvedic literatures and Nighantus for their Rasayana and Bala-vardhaka properties (immunomodulatory actions). They also possess the restorative and rejuvenating powers as they act on the immune system and positively affect the response of the body towards disease causing pathogens. In this review a comprehensive account of the pharmacological activities along with the immunomodulatory activities of Vidhara- Amalaki yog (compound formulation of Vidhara and Amalaki) are included in view of the many recent findings of importance on this plant.

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Patel, Kalpana, Gandhi Vasima, Purvi Shah, and Vaishali Thakkar. "Validated high‐performance thin‐layer chromatographic densitometric method for quantification of gallic acid, quercetin, and ursolic acid in the combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts." SEPARATION SCIENCE PLUS, January 4, 2024. http://dx.doi.org/10.1002/sscp.202300083.

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AbstractA quantitative high‐performance thin‐layer chromatography method has been developed for the estimation of three markers gallic acid, quercetin, and ursolic acid in the extracts and combined formulation of Emblica officinalis, Punica granatum Linn, and Ocimum sanctum Linn extracts. Chromatographic development was performed using precoated silica gel 60 F254 TLC plate and final optimized mobile phase as toluene:ethyl acetate:formic acid (4.5:3:0.2 v/v/v), resulting in optimum resolution with Rf of 0.29, 0.51, and 0.78 for gallic acid, quercetin, and ursolic acid, respectively. Gallic acid and quercetin were detected at 258 nm and ursolic acid at 529 nm after derivatization. All markers showed a good correlation coefficient of 0.9950 for gallic acid, 0.9953 for quercetin, and 0.9945 for ursolic acid. The accuracy and precision measured were less than 2% relative standard deviation for all markers. The mean percent recovery found for gallic acid, quercetin, and ursolic acid were within acceptable limits in formulation indicating that the excipients present have no interference. The proposed method was found to be specific, accurate, linear, precise, and robust, and can be applicable for the simultaneous estimation of gallic acid, quercetin, and ursolic acid for the analysis of individual plant extracts and herbal formulation.

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Singh, Brijesh. "BRIEF REVIEW AND ANTI-MICROBIAL STUDY OF HARITAKI (TERMINALIA CHEBULA RETZ.), AMALAKI (EMBLICA OFFICINALIS GAERTN.), PIPPALI (PIPER LONGUM LINN), CITRAKA (PLUMBAGOZEYLANICA LINN.) AND AMALAKYADIGANA." World Journal of Pharmaceutical Research, July 1, 2017, 1603–10. http://dx.doi.org/10.20959/wjpr20177-8891.

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-, Jyoti Sharma, and Rohit Johari -. "Efficacy of Medicinal Woods/trees Vis-a-Vis Environmental Pollution." International Journal For Multidisciplinary Research 5, no. 1 (January 6, 2023). http://dx.doi.org/10.36948/ijfmr.2023.v05i01.1313.

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Woods/trees a lovely, non-demanding, and most kind entity on our earth. All living beings on this planet depend on the wood/trees in some prospective. As they fight against not only against the diseases but tackles environmental pollution which is brought on by increased industrialization, excessive use of chemicals and plastics. Wood/trees play a crucial role in maintaining a healthy atmosphere and stabilize our climate. By limiting the passage of dangerous pollutants and dust particles, wood/trees also enhance the quality of the air. Few medicinal wood/trees, by virtue of their brilliant purifying abilities and therapeutic advantages, beyond treating diseases plays a significant role in the management of environmental pollution. Woods/trees by consuming carbon dioxide by the process of photosynthesis in potentially diminish environmental pollution by locking up the carbon which is caused by the burning of fossil fuels. Ancient System of Medicine, Ayurveda also has suggested to plant trees like Emblica officinalis Gaertn., Cedrus deodara Roxb. etc. and herbs like Ocimum sanctum Linn. to encounter environmental pollution. The present study will discuss strategic methodology of selected woods/trees in context to traditional synonyms mentioned and their mode of action to tackle environmental pollution.

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Hegde, Sanath Kumar, Suresh Rao, Pratima Rao, Shamprasad Varija Raghu, Sharake Meera, and Manjeshwar Shrinath Baliga. "Aqueous Extract of Emblica officinalis Linn (Indian gooseberry) in Combination with Iodine is More Efficacious than Iodine Alone in Mitigating Mucositis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: Retrospective Observations." Indian Journal of Otolaryngology and Head & Neck Surgery, January 11, 2022. http://dx.doi.org/10.1007/s12070-021-03059-w.

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Uddin, Sultan Sala, and Md Shahidul Islam. "ANTI-INFLAMMATORY, ANALGESIC AND COGNITIVE ENHANCER PLANTS PRESENT IN BANGLADESH: A STUDY REVIEW." Universal Journal of Pharmaceutical Research, November 15, 2020. http://dx.doi.org/10.22270/ujpr.v5i5.490.

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In present scenario the exploit of conventional medicine is enlarging to newer prospects in addition to plants still stay as the original source of the structurally significant compounds that guide to the expansion of the innovative drugs. Recently Bangladesh has concerning forty five thousands plant variety among which therapeutic assets has been treated to the several thousands. The conventional Bangladeshi system of the medicine, Ayurveda reveals the exercise of the plants in treatment of the various diseases. The ethnobotanical investigation done in the most recent few decades have revealed cognitive, anti-inflammatory as well as analgesic actions of the plants mentioned in the conventional literature. Numerous herbal groundings are being stipulated as the anti-inflammatory, cognitive as well as analgesic in traditional literature. The research for innovative anti-inflammatory, cognitive and analgesic agents from enormous array of the medicinal plant sources is escalating. This reviews such type of the plant species in addition to their products which have demonstrated experimental and clinical anti-inflammatory and also analgesic, cognitive actions, the possible method of the action in addition to their therapeutic value. Several of the significant taxa which are originated efficient as cognitive, anti-inflammatory and analgesic agents such as Callophyllum inophyllum L, Ananas comosus (L.) Merr., Calotropis gigantea (L.) R.Br., Camellia sinensis (L.) Kuntz., Calotropis procera (Ak.) R.Br., Cannabis sativa L., Curcuma longa L., Kalanchoe crenata Andr., Spillanthes acmella Murr, Mangifera indica L., Ricinus communis Linn., Sida cordifolia L., Zingiber officinale Roscoe, Ginkgo biloba , Zizyphus jujube, Emblica Officinalis, Cocos nucifera, Celastrus paniculatus. Here these plants species have shown contrasting degrees of cognitive, anti-inflammatory as well as analgesic activities. Peer Review History: Received: 4 September 2020; Revised: 6 October; Accepted: 27 October, Available online: 15 November 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com Dr. Hatem Sameir Abbas, Al-Azhar University, Egypt, hsam8406@yahoo.com Comments of reviewer(s): Similar Articles: A REVIEW ON MEDICINAL USES OF DIFFERENT PLANTS OF EUPHORBIACEAE FAMILY EXPLORING THE ANTIPARASITIC ACTIVITY OF MEDICINAL PLANTS A STUDY ON DIFFERENT PLANTS OF APOCYNACEAE FAMILY AND THEIR MEDICINAL USES PHYTOCHEMISTRY STUDY OF PLANTS BELONGING TO CAPPARIS

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Dey, Sharmistha, Shiwani Kumari, Abhinay Kumar Singh, and Yudhishthir Yadav. "Circulatory GSK‐3beta a new target against Alzheimer’s disease." Alzheimer's & Dementia 19, S14 (December 2023). http://dx.doi.org/10.1002/alz.072751.

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AbstractBackgroundAlzheimer’s disease (AD) is the progressive brain disorder which degenerate brain cells connection and causes memory loss. Though, AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. However, this would only be possible if the disease is diagnosed at an early stage and early diagnosis requires clear understanding of pathogenesis at molecular level. Overactivity of GSK‐3β and p53 accounts for tau hyperphosphorylation, and amyloid‐β plaqueMethodWe explored GSK‐3β and p53 as blood‐based biomarkers for early detection of AD. Methods: The levels of GSK‐3β, p53, and their phosphorylated states were measured using surface plasmon resonance and verified using Western blot in serum from AD, mild cognitive impairment (MCI), and geriatric‐control (GC) subjects. The neurotoxic SH‐SY5Y cell line was treated with antioxidant Emblica Officinalis (EO) for rescue effect.ResultGSK‐3β, p53, and their phosphorylated state were significantly over expressed (p>0.001) in AD, MCI compared to GC and can differentiate AD, MCI from GC. The expression level of GSK‐3β and p53 proteins were found to be downregulated in a dose‐dependent manner after the treatment with EO in amyloid‐β induced neurotoxic cells.ConclusionThese proteins can serve as potential blood markers for the diagnosis of AD and EO can suppress their level. This work has translational value and clinical utility in the future.

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Jayakumar, Remya, Manoj Kumar Dash, Saumya Gulati, Akanksha Pandey, Surendra Kumar Trigun, and Namrata Joshi. "Preliminary data on cytotoxicity and functional group assessment of a herb–mineral combination against colorectal carcinoma cell line." Journal of Complementary and Integrative Medicine, November 30, 2023. http://dx.doi.org/10.1515/jcim-2023-0221.

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Abstract Objectives The invasive screening methods and the late stage diagnosis of colorectal carcinoma (CRC) are contributing for the devastative prognosis. The gradual shift of the disease pattern among younger generations requires the implementation of phytochemicals and traditional medicines. Arkeshwara rasa (AR) is a herb–mineral combination of Tamra bhasma/incinerated copper ashes and Dwigun Kajjali/mercury sulphide levigated with Calotropis procera leaf juice, Plumbago zeylanica root decoction and the decoction of three myrobalans (Terminalia chebula, Terminalia bellerica, Emblica Officinalis decoction)/Triphala decoction. Methods The SW-480 cell line was checked for the cytotoxicity and the cell viability criteria with MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. The acridine orange/ethidium bromide (AO/EtBr) assay revealed the depth of apoptosis affected cells in the fluorescent images. The FTIR analysis exhibited the graphical spectrum of functional groups within the compound AR. Results The IC50 from the 10−7 to 10−3 concentrations against SW-480 cells was 40.4 μg/mL. The staining of AO/EtBr was performed to visualize live and dead cells and it is evident from the result that number of apoptotic cells increases at increasing concentration of AR. The single bond with stretch vibrations of O–H and N–H are more concentrated in the 2,500–3,200 cm−1 and 3,700–4,000 cm−1 of the spectra whereas, the finger print region carries the O–H and S=O type peaks. Conclusions The AR shows strong cyto-toxicity against the SW-480 cells by inducing apoptosis. It also modulates cellular metabolism with the involvement of functional groups which antagonizes the strong acids. Moreover, these effects need to be analyzed further based in the in vivo and various in vitro models.

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Journal articles on the topic 'Emblica officinalis linn'

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