Journal articles on the topic 'Elisa Alicia'

A partir del análisis narrativo, televisual y hermenéutico de tres exitosas telenovelas nocturnas chilenas del subgénero policial —Alguien te mira (Rencoret, 2007), ¿Dónde está Elisa? (Demicheli y Campos, 2009) y El laberinto de Alicia (Demicheli y Aguirre, 2011)—, este artículo se pregunta por las representaciones de género que ofrecen estos relatos. Los resultados indican que estas telenovelas son un producto híbrido que combina el melodrama clásico con el relato policial. A diferencia de las producciones diurnas y vespertinas, los protagonistas aquí son de la clase alta; y el relato es ágil y dinámico, y juega con el secreto y el suspenso. Sin embargo, en una lectura de género, puede verse que, aunque las mujeres son presentadas inicialmente como autónomas, independientes y empoderadas, finalmente terminan cumpliendo un rol clásico: el de madres.

Desde la restitución de la democracia en Argentina en 1983, hubo mujeres que dieron su testimonio sobre el terrorismo de estado y lo enmarcaron en las diferentes temporalidades y disputas políticas dentro de las luchas por las memorias. Sin embargo, fueron minoría los relatos que, más allá de aquellas instancias, problematizaron la relación entre violencia política y género, y menos aún las que además reflexionaron sobre el acto de escritura. En este artículo me interesa trabajar ambos aspectos, para ello analizo cuatro libros pioneros en plantear las relaciones entre mujeres, violencia política y terrorismo de estado en Argentina: The Little School. Tales of disappearence and survival (1998) de Alicia Partnoy, Mujeres Guerrilleras. La militancia de los setenta en el testimonio de sus protagonistas femeninas (1997), de Marta Diana; Pájaros sin luz. Testimonio de mujeres de desaparecidos (1999) de Noemí Ciollaro y Ese Infierno. Conversaciones de cinco mujeres sobrevivientes de la ESMA (2001) de Munú Actis, Cristina Aldini, Liliana Gardella, Miriam Lewin y Elisa Tokar.

Este artículo se centra en la novela Madame Lynch, escrita por la feminista paraguaya María Concepción Leyes de Chaves en el año 1957, es decir, en el momento en que la lucha por el voto femenino estaba en el punto más álgido en su país. En esta obra, la autora consigue reconstruir y darle un nuevo perfil a Elisa Alicia Lynch, un personaje femenino cuya moral había sido cuestionada públicamente porque había sido amante y madre de los hijos del presidente Francisco Solano López, aun cuando se había casado previamente con otro hombre; porque influyó en las decisiones políticas de su marido y opinó públicamente acerca de la Guerra de la Triple Alianza; y porque renegó de su educación familiar desde muy temprana edad. La primera mitad del artículo comienza con una panorámica del momento de publicación de la novela, algunas referencias acerca del movimiento de mujeres en Paraguay y su relación con el stronismo; sigue con un recorrido de las distintas reconstrucciones que se hicieron de Madame Lynch -antes y después de su muerte- en la prensa y la literatura; y desemboca en una presentación de María Concepción Leyes de Chaves como subjetividad social. Tras el establecimiento de este marco de lectura, la segunda mitad del texto se centra en el análisis de la novela Madame Lynch desde la teoría de los afectos. Esta aproximación permitirá constatar cómo, en esta novela, se desplazan los significados y las emociones que circundaron al personaje por décadas y, con ello, se abre un debate sobre la identidad de las mujeres políticas. Dado el activismo de la escritora y el momento que atravesaba la nación cuando aparece la obra que nos ocupa, será sencillo percibir cómo María Concepción se sirvió de su centralidad y de la literatura para convertir las identidades de las mujeres políticas en elementos deseables para su presente y, de ese modo, argumentar a favor de la participación de las mujeres en los espacios de toma de decisión.

Abstract Objective: 1st: Assess the presence of residual infiltrating component in the surgical specimen of patients with Luminal Her2- tumors ≤ 2cm and ultrasound-negative axilla, following ultrasound-guided cryoablation. 2nd: Demonstrate that preoperative seed placement prior to cryoablation does not interfere with tumor cell elimination by freezing. Methods: Between April 2021 and April 2023, we performed preoperative cryoablation on 52 patients aged 53 to 79 years (mean 64) with 52 unifocal invasive ductal carcinomas (IDC) measuring 4 to 20 mm (mean 10), low grade (24 G1, 28 G2), 31 Luminal A and 21 B, Ki67 between 3 and 30% (mean 13). On ultrasound, all IDCs were visible and axilla-negative. 26 of them (50%) were referred from the screening program of the Community of Madrid. The tumor-to-skin surface distance ranged from 2 to 18 mm (mean 9 mm). All patients underwent mammography-tomosynthesis, staging, and biopsy under ultrasound guidance. The minimum time elapsed until surgery was 6 days, and the maximum was 78 days (mean 22). All patients underwent mammography-tomosynthesis, staging, and biopsy under ultrasound guidance. MRI was performed to rule out extensive intraductal component in 17 out of 20 patients with associated intraductal carcinoma (IDC) in the diagnostic biopsy. Preoperative marking with ferromagnetic seed placement was performed in all cases prior to cryoablation, using a single dose of anesthesia and through the same skin access. We used the ICEfx Galil Boston Scientific cryoablation system with 17G or 14G needles, applying the standard triple-phase protocol: freezing-passive thawing-freezing for approximately 40 minutes. The correct placement of the seed was subsequently confirmed by mammography. Results: There were no significant complications in any case. Out of 52 low-risk unifocal IDCs: -32 were pure IDCs (without associated intraductal component in diagnostic biopsy): no residual IDC was identified in the tumor specimen. -20 were mixed IDCs (with associated IDC in the diagnostic biopsy): *In 4 cases, residual IDC was found in the surgical specimen, with some foci of IDC remaining at the periphery of the post-cryoablation necrosis. *In 8 patients, foci of IDC were detected distant from the cryoablation zone. The pathologist determined that all samples had tumor-free margins. Conclusions: Cryoablation is effective in 100% of cases for pure infiltrating tumors ≤ 2cm. The presence of scattered IDC nests away from the cryoablation zone or at the margin of fat necrosis does not indicate technique failure, as all surgical specimens were determined to have tumor-free margins by the pathologist. For mixed infiltrating tumors, the ice ball should broadly cover the tumor size estimated by ultrasound and MRI. Standard adjuvant treatment will equalize the risk of recurrence with conventional lumpectomy. Table 1: 52 cases IDC unifocal ≤2cm Table 2: IDC Pure ≤2cm. Table 3: IDC mixed: IDC+DCIs ≤2cm Analysis of surgical specimen Citation Format: Maria José Roca Navarro, Pilar Zamora, Ylenia Navarro Monforte, Diego Garrido Alonso, Vicenta Córdoba Chicote, Teresa Diaz de Bustamante Durban, José María Oliver Goldaracena, Laura Yebenes Gregorio, Covadonga Marti, Jose Ignacio Sanchez-Mendez, Elisa Moreno, Laura Frías Aldeguer, Adolfo Loayza Galindo, Alberto Berjón García, Marcos Melendez Gisper, Carmen Martín Hervás, Lara Miralles, Cristina Escabias del Pozo, Younes Abadi, Elisa York Pineda, Gonzalo Garzón Moll, David Hardisson Hernáez, Alicia Hernández Gutiérrez, César Casado Sánchez, Virginia Martínez Marín, Shirin Zarbakhsh, Joaquin Gomez Ramirez. Preoperative cryoablation in 52 Her2- Luminal invasive ductal carcinomas ≤ 2cm. Analysis of the tumor specimen [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-01-12.

En un pasaje ya clásico de Lewis Carroll, Alicia pregunta al Gato de Chesire por qué camino ha de andar a lo que este le responde con un nuevo cuestionamiento de ¿A dónde quieres ir? Para Alicia la respuesta no es importante por lo que el gato responde que en consecuencia tampoco es trascendente el camino que elija. En El derecho penal frente a la discriminación laboral algorítmica del Dr. Alfredo Abadías se expresa «Nos encontramos en una sociedad cambiante, que fluctúa, que navega sin un claro norte por la creciente incertidumbre y la falta de seguridad».

Abstract Background: While there is growing evidence that physical activity increases ovarian cancer risk, studies to date have been focused primarily on women of European ancestry. Little is known about whether physical inactivity is also associated with ovarian cancer risk in women of African ancestry. Methods: In three studies in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium (Los Angeles County Ovarian Cancer Study, the Southern Community Cohort Study, and the Women’s Health Initiative), we classified women as being physically inactive in their lifetime (yes/no) by either a ‘no’ response to a question about ever participating in regular, weekly, recreational physical activity (case-control study), or if participants reported no regular weekly moderate or vigorous recreational physical activity in all time periods prior to the reference date (cohort studies). We evaluated associations of lifetime physical inactivity and ovarian cancer risk overall and according to histologic subtype (high-grade serous, non-high-grade serous) and stage (localized/regional, distant). Associations were estimated using logistic regression models adjusted for age, study, education, parity, oral contraceptive use, menopausal status, tubal ligation status, postmenopausal hormone use, smoking status, and family history of breast/ovarian cancer. Results: The sample includes 195 African ancestry (AA) cases, 606 AA controls, 2,009 White cases, and 7,229 White controls. AA women had a higher proportion of chronic inactivity than White women: 94 (48%) of cases and 182 (30%) of controls, vs 576 (29%) of cases and 1,467 (20%) of controls, respectively. In AA women, we observed higher risk for invasive ovarian cancer (OR=1.49, 95% CI: 1.02, 2.18) for women who were physically inactive, compared to physically active women. In AA women, no heterogeneity in this association was observed by histologic subtype, but when stratified by stage, we found higher odds of ovarian cancer for physically inactive women with localized/regional stage disease (OR: 2.24, 95% CI: 1.22, 4.09) and no association among women with distant stage disease (OR: 1.18, 95% CI: 0.75, 1.85). In White women, we observed borderline significant associations for invasive ovarian cancer only (OR=1.12, 95% CI: 0.99, 1.27); no differences in this association were observed by histotype or stage. Conclusion: Our study suggests that physical inactivity contributes to invasive ovarian cancer risk in AA women. Citation Format: Albina Minlikeeva, Sarah M. Lima, Courtney Johnson, Elisa V. Bandera, Alicia Beeghly-Fadiel, Traci N. Bethea, Jessica Petrick, Charlotte E. Joslin, Evan Myers, Holly R. Harris, Lauren C. Peres, V. Wendy Setiawan, Anna H. Wu, Lynn Rosenberg, Joellen M. Schildkraut, Heather M. Ochs-Balcom. Physical inactivity is associated with ovarian cancer in women of African ancestry [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr B037.

Abstract Introduction: Black women with epithelial ovarian cancer (EOC) have worse survival compared to other racial groups, and the causes of these poor outcomes remain unclear. Compared to other racial groups, Black women are disproportionately affected by comorbid conditions which can adversely impact cancer care and outcomes. Thus, we examined the association of pre-diagnostic comorbid conditions and their associated medications with survival among Black women with EOC. Methods: Using data from Black women with EOC in the African American Cancer Epidemiology Study, we evaluated the self-reported Charlson comorbidity index (CCI) and three cardiometabolic comorbidities (diabetes mellitus, hypertension, and hyperlipidemia). We also characterized whether women with each cardiometabolic condition were using medication for their condition. Kaplan-Meier survival curves and log-rank tests were used to examine survival by the CCI, each cardiometabolic comorbidity, and medication use. Cox proportional hazards regression models were used to examine the association of comorbid conditions and medications with survival while adjusting for age at diagnosis, stage, histotype, and study site. Results: Among 592 Black women with EOC, 35% had a CCI ≥2, and the prevalence of diabetes, hyperlipidemia, and hypertension was 19%, 31%, and 62%, respectively. Among women with each cardiometabolic condition, the prevalence of medication use for diabetes, hypertension, and hyperlipidemia was 73%, 78%, and 60%. In bivariate analyses, women with a higher CCI, diabetes, hyperlipidemia, and hypertension had worse survival compared to women without these conditions (P<0.05). However, when adjusting for prognostic factors, only a high CCI (≥2 vs. 0) and diabetes were significantly associated with higher hazard of death (HR=1.36, 95% CI=1.06-1.74 and HR=1.40, 95% CI=1.08-1.81, respectively). Investigating the independent associations of each condition included in the CCI with survival revealed that diabetes was largely driving the association of CCI with survival. When considering medication use, women with diabetes, irrespective of medication use, women with hypertension not on medication, and women with hyperlipidemia on medication had worse survival compared to women without these conditions in bivariate models (P<0.05). Compared to women without diabetes, women with diabetes on medication and women with diabetes not on medication had a statistically significant higher hazard of death in multivariable models (HR=1.39, 95% CI=1.02-1.88 and HR=1.63, 95% CI=1.04-2.57, respectively). No associations with survival were observed when considering medication use for hypertension and hyperlipidemia after adjusting for prognostic factors. Conclusion: Similar to prior studies among White women with EOC, diabetes, regardless of medication status, was strongly associated with poorer survival among Black women with EOC. Citation Format: Alicia Richards, Courtney E. Johnson, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Michele L. Cote, Theresa A. Hastert, Kristen Haller, Jeffrey R. Marks, Edward S. Peters, Paul D. Terry, Andrew B. Lawson, Joellen M. Schildkraut, Lauren C. Peres. Pre-diagnostic comorbid conditions and survival among black women with ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4829.

Abstract PURPOSE: Women with endometriosis have a 2 to 3-fold greater risk of endometrioid and clear cell ovarian cancer than other women, based on estimates from studies predominantly of White women. Fibroids have not been consistently associated with ovarian cancer risk but are the most common indication for hysterectomies in the U.S. Hysterectomy has been associated with lower ovarian cancer risk in subgroups of women including those with fibroids; thus fibroids may indirectly impact ovarian cancer risk. We evaluated the association of endometriosis and fibroids with ovarian cancer risk among Black and White women, taking into consideration the impact of hysterectomy. METHODS: We used data from six studies in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium. Participants included 2,995 Black women and 5,281 White women. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between endometriosis and fibroids with ovarian cancer risk, overall, by race, and stratified by histotype. We also assessed effect modification by hysterectomy. RESULTS: Overall the prevalences of endometriosis and fibroids were 6.4% and 43.2% among Black women and 7.0% and 21.5% among White women, respectively. Endometriosis was associated with an increased risk of endometrioid and clear cell ovarian cancer in Black and White women. Among Black women the association was strongest for endometrioid tumors (OR=7.06; 95% CI=3.86-12.91) compared to White women (OR=2.17; 95% CI=1.36-3.45) with a significant difference by race (phetereogeneity=0.003). When stratified by hysterectomy the association between endometriosis and ovarian cancer risk in White women was stronger in those who did not report a hysterectomy. However, in Black women, the elevated risk of ovarian cancer among women with endometriosis was present among those with and without hysterectomy. Fibroids were associated with a slightly elevated risk of ovarian cancer in Black (OR=1.34; 95% CI=1.11-1.62) and White women (OR=1.22; 95% CI=1.05-1.41). For both groups, the association was present only in those who did not report a hysterectomy. Black women who had a history of fibroids and no hysterectomy had a 53% greater odds of ovarian cancer (95% CI=1.23-1.89) compared to those without fibroids, while there was no association with fibroids in the hysterectomy group (OR=0.92, 95% CI=0.62-1.36) (pinteraction=0.05). A similar pattern was observed among White women, but the interaction was not significant (pinteraction=0.21). CONCLUSION: Both Black and White women with endometriosis had a higher risk of ovarian cancer, and hysterectomy modified this association only among White women. Fibroids were associated with modestly increased risk of ovarian cancer among Black and White women, with hysterectomy modifying the risk in both groups. Further research is needed to understanding how racial differences in diagnoses of these conditions, and differential access to care and treatment options, impact or modify ovarian cancer risk. Citation Format: Holly Harris, Lauren Peres, Courtney Johnson, Kristin Guertin, Alicia Beeghly-Fadiel, Elisa Bandera, Traci Bethea, Charlotte Joslin, Anna Wu, Patricia Moorman, Heather Ochs-Balcom, Jessica Petrick, Veronica Setiawan, Lynn Rosenberg, Joellen Schildkraut, Evan Myers. Racial differences in the association of endometriosis and fibroids with risk of ovarian cancer [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C105.

Abstract BST2, a raft-associated type II transmembrane protein, functions as a restriction factor and inhibits HIV release by cross-linking virions onto infected cell surfaces. It also engages ILT7, a specific inhibitory receptor on plasmacytoid dendritic cells, which are associated with poor prognosis when infiltrate patients’ breast tumors. Two groups have identified BST2 isoforms of different lengths, generated by post-transcriptional modification. Based on these findings and our work on protein interaction of ILT7-BST2, we hypothesized that the expression of BST2 isoforms differed in normal and cancer tissues. To demonstrate that, we generated and characterized anti-long BST2 isoform monoclonal antibodies (mAbs). Results were compared with our previously developed mAb anti-BST2 full length molecule, 26F8, that recognizes a common epitope to all BST2 isoforms. By comparing the amino acid sequences of different isoforms of BST2, we identified a region of 24 residues on the extracellular domain of BST2, restricted to its long isoform. We then generated mAbs by hybridoma technology, immunizing BALB/c mice with the 24 mers peptide-KLH conjugated. Screening and positive selection of several clones were performed following our lab SOP. One of the mAbs, LA5, was selected based on positive ELISA against the immunogen and FACS staining of recombinant HEK293 cells expressing full-length BST2 protein. Pharmacokinetic determined using OCTET platform, revealed a KD of 4.61+/- 0.074 × 10−9 M for LA5. Epitope mapping of LA5 on BST2 overlapping peptides, confirmed specific recognition of full-length BST2 protein and the peptide used as immunogen. LA5 heavy and light chains were sequenced and analysis was performed by IgBlast and IMGTV. Binding of LA5 and 26F8 to the myeloma cell lines MM1 (B-lymphoblast) and U266 (B-lymphocyte) by flow cytometry, indicated 97-100% positive cells with both mAbs, with higher MFI values observed for clone 26F8: 5.8 and 1.8-fold-increase in MM1 and U266 cells respectively. IHC on formalin-fixed paraffin embedded tissues of human ductal breast carcinoma, revealed that LA5 staining was able to identify infiltrating carcinoma cells but not the normal surrounding acinar cells. In contrast, 26F8 staining did not discriminate between BST2+ malignant and surrounding normal acinar cells. Currently, we are analyzing a panel of >105 breast cancer tissue samples of different molecular classifications. Initial data revealed a high-level of expression of BST2 (by 26F8) on the epithelial area of the tumors, lower in the TME (tumor microenvironment-infiltrating immune cells) and almost negative expression in the surrounding fibroblasts rich stroma. Evaluation of IHC staining by LA5 is being processed and yet to be established. These IHC findings indicate a potential diagnostic value of LA5 to distinct between tumor and normal cells in patients’ specimens. Treatment prospects may arise during the process. Citation Format: Laura C. Bover, Ahmed Muhsin, Long T. Vien, Felipe Amaya Manzanares, Zhuang Wu, Janis D. Johnson, Diego Castro Reyes, Myrthala Moreno-Smith, Estefania Labanca, Irene Sorin, Silvia Saucedo, Silvina Gazzaniga, Alicia I. Bravo. Monoclonal antibody against BST2 isoform: potential tool for diagnostic and cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6350.

Abstract Background: Oncogenic FGFR2 alterations (fusions/rearrangements [f/r], amplifications, mutations) drive multiple solid tumors. Pan-FGFR inhibitors have validated FGFR2 as an actionable target in cholangiocarcinoma (CCA), however, activity has been limited by off-isoform toxicity and on-target resistance. Lirafugratinib (RLY-4008), the first highly selective FGFR2 inhibitor, was studied in ReFocus, an ongoing Phase I/II study (NCT04526106) in advanced FGFR2-altered solid tumor patients (pts). Previously, we defined the RP2D, confirmed the selective mechanism that minimizes off-isoform toxicity (FGFR1-hyperphosphatemia; FGFR4-diarrhea), and reported efficacy in CCA pts with FGFR2 f/r. Here, we report initial efficacy and safety from pts with solid tumors other than CCA treated at the RP2D. Methods: Pts with advanced solid tumors and FGFR2 alterations identified per local testing enrolled and received lirafugratinib orally. Key objectives were investigator-assessed objective response rate (ORR), duration of response (DOR), and safety. Efficacy was analyzed in pts with measurable disease, no prior FGFRi therapy and an opportunity for ³1 post-baseline imaging assessment. Safety was analyzed in all pts. Results: As of 09May23, 98 pts with solid tumors other than CCA (21 tumor types) were enrolled and treated at the RP2D. Fifty-three percent of pts had ³3 prior therapies; 19% had prior FGFRi therapy. Median treatment exposure was 8.3 weeks (range: 0.1–55.7). Of 79 FGFRi-naïve pts, 61 were evaluable; 18 unevaluable (1 nonmeasurable; 17 ongoing pending imaging). Twenty had f/r with an ORR of 40% (8/20, 7 confirmed/5 ongoing) and DOR from 8-50+ weeks. Twenty-seven had amplification with an ORR of 33% (9/27, 7 confirmed/5 ongoing) and DOR from 8-32+ weeks. Pts with breast (n=7), lung (n=3), and pancreatic (n=5) cancer with FGFR2 f/r or amplification had confirmed ORRs of 43%, 67%, and 40%, respectively. Response varied by mutation with ORR 14.3% (2 [N549K; C382R]/14; both confirmed, 1 ongoing) with DOR each of 40+ weeks. Most common treatment-related adverse events (TRAEs, all grades; grade 3) were stomatitis (50%; 10%), nail toxicities (44%; 4%), and palmar-plantar erythema (45%; 5%). Typical off-isoform TRAEs for pan-FGFR inhibitors were uncommon, including hyperphosphatemia (16%; 0%) and diarrhea (9%; 1%). One percent of pts discontinued treatment because of TRAEs. No grade 4/5 TRAEs were observed. Conclusion: Beyond CCA, lirafugratinib demonstrates promising initial efficacy in multiple tumor types with diverse FGFR2 alterations including f/r, amplification, and select mutations. Together with lirafugratinib’s differentiated safety profile (minimal off-isoform toxicity), these efficacy data validate FGFR2 as a tumor agnostic target sensitive to selective FGFR2 inhibition. Pivotal development across solid tumors continues in Phase 2 of ReFocus. Additional/updated data will be presented at the conference. Citation Format: Alison M Schram, Vivek Subbiah, Chih-Yi (Andy) Liao, Victor Moreno, Roda Desamparados, Mariano Ponz-Sarvise, Efrat Dotan, Philippe Alexandre Cassier, Irene Moreno, Andreas Varkaris, Richard D Kim, Elena Garralda, Frans Opdam, David Tai, Antoine Italiano, Do-Youn Oh, Lipika Goyal, Elisa Fontana, Jia Liu, Myrto Boukovala, Francois Ghiringelli, Mitesh J Borad, Hani Babiker, Zhaohui Jin, Michael Millward, Jeffrey Yachnin, Suneel Deepak Kamath, Jermaine M. Coward, Changhoon Yoo, Robin Kate Kelley, Vaibhav Sahai, John Bridgewater, Christoph Springfield, Vaia Florou, Anthony El-Khoueiry, Ferry Eskens, Bruce Lin, Scott Paulson, Giuseppe Curigliano, Meredith Murphy, Alicia Deary, Fabien Ricard, Kai Yu Jen, Florence (Tianhui) Ramirez, Rick E. Blakesley, Oleg Schmidt-Kittler, Brenton G. Mar, Joon Oh Park, Antoine Hollebecque. Clinical activity of lirafugratinib (RLY-4008), a highly selective FGFR2 inhibitor, in patients with advanced FGFR2-altered solid tumors: The ReFocus study [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr IA006.

RESUMO: A caprinocultura na região Nordeste do Brasil desempenha importante função socioeconômica e estratégica. A rusticidade desta atividade nesta região, aliada a sua rápida expansão em outros estados, tem gerado perdas na sua cadeia produtiva a nível regional e nacional, causadas por doenças infecciosas, destacando-se a Linfadenite Caseosa (LC), afecção amplamente difundida nos rebanhos caprinos, acarretando sérios prejuízos econômicos à atividade. Embora LC tenha sido detectada como um problema endêmico no nordeste brasileiro, uma análise abrangente e mais recente desta prevalência nos rebanhos caprinos brasileiros se faz necessária. O objetivo desse estudo foi determinar a frequência de anticorpos anti-Corynebacterium pseudotuberculosis em cinco dos nove estados que compõem a região Nordeste do Brasil. Foram processadas amostras de soro de 2571 caprinos provenientes de 218 propriedades rurais oriundas de cinco estados da região Nordeste do Brasil, coletadas entre os anos de 2010 a 2012. O diagnóstico da infecção por C. pseudotuberculosis foi realizado pela técnica de ELISA-indireto. Em 88,5% (193/218) das propriedades investigadas, pelo menos um caprino foi soropositivo para C. pseudotuberculosis, sugerindo que o agente se encontra disseminado nos rebanhos do Nordeste, com a maior prevalência encontrada no Rio Grande do Norte (94,5%) e a menor no estado de Sergipe (70,3%). Foram identificados 783 (30,4%; IC 95%=28,7-32,2%) caprinos soropositivos, com a maior prevalência entre animais encontrada no Piauí (41,4%) e a menor no estado de Sergipe (22,5%). De um total de 279 reprodutores avaliados, 106 (37,9%) resultaram soropositivos, destacando-se o Rio Grande do Norte, com 45,30%, e Piauí com 46,8% dos reprodutores positivos para LC. Das 1420 matrizes testadas, 599(42,1%) apresentaram sorologia positiva para C. pseudotuberculosis. Entre os estados esta distribuição também se manteve semelhante, destacando-se o Rio Grande do Norte, com 47,5% e Piauí com 59,5% das matrizes positivos para LC. Entre os 872 caprinos jovens avaliados, 78 (8,9%) foram soropositivos para LC, observando-se uma diferença estatística na frequência de sopositividade obtidas entre os adultos e os jovens (P<0,001). Reforça-se a necessidade do diagnóstico da enfermidade em rebanhos caprinos da região Nordeste para possível implementação de programas de controle da doença e medidas mais precisas no manejo da LC junto aos criadores de caprinos.

Book reviews - Crítica de libros - Crítica de livros Markus Lampe & Paul Sharp: A Land of Milk & Butter. How Elites Created the Modern Dairy Industry Carin Martiin Christopher Dyer, Erik Thoen and Tom Williamson: Peasants and their fields. The rationale of open-field agriculture, c. 700-1800 José Luis Martínez-González Juan Antonio Quirós Castillo (Ed.): Archaeology and History of Peasantries 1. From the Late Prehistory to the Middle Ages. Guillermo García-Contreras Ruiz Dietmar Müller: Bodeneigentum und Nation. Rumänien, Jugolawien und Polen im europäischen Vergleich Miguel Cabo Villaverde Fernando Collantes y Vicente Pinilla: ¿Lugares que no importan? La despoblación de la España rural desde 1900 hasta el presente Javier Esparcia Francesc Valls Junyent: La Catalunya atlántica. Aguardiente y tejidos en el arranque industrial catalán Llorenç Ferrer-Alòs Elena Catalán Martínez, Gabriel Jover Avellà y Enrique Llopis Agelán (Eds.): El delme com a font per a la història rural Pegerto Saavedra Jaume Torras Elias: Canvis i conflictes en el món rural català (segles xviii-xix). Onze estudis d’història econòmica i social Jesús Millán García-Varela Miguel Ángel del Arco Blanco (Ed.): Los «años del hambre». Historia y memoria de la posguerra franquista José Miguel Martínez Carrión Fernando Collantes: ¿Capitalismo coordinado o monstruo de Frankenstein? La Política Agraria Común y el modelo europeo, 1962-2020 Alicia Langreo Navarro Sergio Molina García: Una llave para Europa. El debate agrario franco-español y la adhesión de España a la CEE (1975-1982) Rafael Castro

O presente estudo tem como objetivo analisar os aspectos diferenciais entre elementos que constituem coesão e fragmentação na obra Os estabelecidos e os outsiders de Norbert Elias (2000) e História da Civilização na Europa de François Guizot (1907) e, a partir das análises feitas, tecer relações entre os aspectos diferenciais nas obras desses autores e a educação na sociedade contemporânea. Norbert Elias faz uma análise acerca do alto índice de delinquência juvenil na comunidade de Winston Parva e percebe que o fator de fragmentação entre os moradores do local e a coesão inflexível existente entre os antigos residentes do bairro, decorre na ausência de coesão entre os recém-chegados ao bairro, que não dispunham de relações sociais mais antigas para se defenderem das acusações dos estabelecidos. Em Guizot, verificamos que para a constituição de uma civilização, se fazia necessário a coesão da sociedade civil aliada ao desenvolvimento da vida individual. Compreendemos que na sociedade contemporânea, ocorre a valorização exacerbada das questões individuais, em detrimento das relações sociais coletivas, que visa o bem-estar comum para o desenvolvimento integrado da sociedade como um todo. Diante disso, consideramos que o estudo do entendimento que os homens faziam da sociedade de seu tempo, é primordial para compreendermos as questões que determinam as relações sociais do presente século.

The 2019 Annual General Meeting and Young Investigators’ Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherche Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada / Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was held in Banff, Alberta on November 8–10th, 2019. The theme was “Positioning Early Career Investigators for Success: Strategy and Resilience”. Lectures and workshops provided knowledge and tools to facilitate the attendees’ development as clinician investigators. Dr. Jason Berman (President of CSCI/SCRC), Elina Cook (President of CITAC/ACCFC) and Drs. Doreen Rabi and Zelma Kiss (University of Calgary Organizing Co-Chairs) gave opening presentations. The keynote speakers were Dr. William Foulkes (McGill University) (Distinguished Scientist Award winner) and Dr. Andrés Finzi (Université de Montréal) (Joe Doupe Young Investigator Award winner). Dr. Robert Bortolussi (Dalhousie University) received the Distinguished Service Award for his work as the Editor-in-Chief of Clinical and Investigative Medicine and for being instrumental in the development of the Canadian Child Health Clinician Scientist Program. This meeting was the first to host a panel discussion with Drs. Stephen Robbins and Marcello Tonelli from the Canadian Institutes of Health Research. Workshops on communication, career planning and work-life balance were hosted by André Picard and Drs. Todd Anderson, Karen Tang, William Ghali, May Lynn Quan, Alicia Polachek and Shannon Ruzycki. The AGM showcased 90 presentations from clinician investigator trainees from across Canada. Most of the abstracts are summarized in this review. Eight outstanding abstracts were selected for oral presentation at the President’s Forum.

Há milênios, a humanidade vem-se perguntando sobre a natureza do tempo. Das mais remotas civilizações até a atualidade, o tempo tem sido objeto de curioso fascínio e contemplação. Porém, sua existência social, não obstante sua intangibilidade, torna-se cada vez mais presente em nossos dias. Cumprir prazo, cronometrar tarefas, delimitar durações; a vida cotidiana nos exige, progressivamente, uma aceleração das atividades que desempenhamos aliada à racionalização e fragmentação do próprio devir. Vários autores contemporâneos, como Elias, dedicaram-se a investigar sua natureza social. Contudo, conceberam-na, abstratamente, como uma convenção simbólica de aferição e ordenamento dos acontecimentos, desconsiderando os processos que o levam a assumir seu caráter de dominação no seio da sociedade burguesa. Assim, este artigo procura estabelecer um resgate ontológico do tempo ante à função que exerce no interior do modo de produção capitalista, cujo atual contexto neoliberal subjuga-nos aos ininterruptos ritmos laborais da acumulação. Submetido em: 04/04/2020Aceito em: 24/08/2020

Abstract We have previously shown in a phase 3 trial that tamoxifen 5 mg/day for 3 years decreased by 52% the incidence of recurrence of invasive breast cancer or DCIS after a median follow-up of 5.1 years in women with excised non invasive breast disease, including atypical ductal hyperplasia, DCIS or LCIS (DeCensi et al. JCO 2019; 37:1629). Toxicity was negligible with only an extra hot flash per day in the tamoxifen arm compared with the placebo arm. These findings were incorporated into the ASCO clinical practice guidelines for breast cancer risk reduction as an alternative option to standard doses and duration of tamoxifen or aromatase inhibitors in women with non-invasive disease (Visvanathan et al. JCO 2019; 37:3152). In the present study we update the findings on breast cancer recurrence after a median of 9.14 years (interquartile range, IQR, 7.16-10.73) and a total of 10.57 person years of follow up to see if the treatment effect is retained with more events and after a median of approximately 6 years from treatment cessation. We conducted a national multicenter randomized trial of tamoxifen, 5 mg/d or placebo administered for 3 years after surgery in women with hormone-sensitive or unknown breast intraepithelial neoplasia, including atypical ductal hyperplasia and lobular or ductal carcinoma in situ. The primary end point was the incidence of invasive breast cancer or ductal carcinoma in situ. Between November 1, 2008, and March 31, 2015, 1,160 women were screened and 500 aged 75 years of age or younger were included in the study. Women with high-grade or comedo/necrotic DCIS received adjuvant radiotherapy of 50 Gy in 25 courses. The mean age was 54 years (standard deviation, 9 years), and 55% of participants were postmenopausal. The mean (SD) body mass index, kg/m2, was 25.7 (4.8) on tamoxifen and 25.3 (4.2) on placebo. Twenty percent had ADH, 11% had LCIS, and the remaining 69% had DCIS. After a median follow-up of 9.14 years, there were 22 neoplastic events (invasive breast cancer or DCIS) with tamoxifen and 37 with placebo (annual rate 11.09, 95% CI, 7-30-16.84 on T vs 19.71, 95% CI, 14.28-27.21 on P per 1,000 person-years; hazard ratio, 0.56; 95% CI, 0.33 to 0.95; P = .03), which resulted in a 5-year number needed to treat of 18. Overall, 71% of the recurrences were invasive breast cancer. The follow-up was updated with the most recent visit within 12 months in two thirds of the participants, so an update of all participants will be performed by Sept 30th with full analysis of neoplastic events, annual risk rate ratio, serious adverse events and deaths. Moreover, an updated analysis of potential effect modifiers will be conducted, including menopausal status, baseline estradiol levels, menopausal symptoms, BMI, smoking status and Ki-67 of the primary lesion. In conclusion, our findings indicate that low dose tamoxifen given for 3 years still significantly prevents recurrences from non-invasive breast cancer after a median of 6 years from treatment cessation, providing a valid prevention/interception option in this disease group. Supported by Ente Ospedaliero Ospedali Galliera, Genova, Italy, the Italian Ministry of Health (RFPS-2006-1-339898), the Italian Association for Cancer Research (IG 2008 Grant No. 5611), and the Italian League against Cancer (LILT 7-08). Citation Format: Andrea De Censi, Matteo Lazzeroni, Matteo Puntoni, Luca Boni, Aliana Guerrieri Gonzaga, Tania Buttiron Webber, Marianna Fava, Irene Maria Briata, Livia Giordano, Maria Digennaro, Laura Cortesi, Fabio Falcini, Franca Avino, Francesco Millo, Katia Cagossi, Elisa Gallerani, Alessia De Simone, Anna Cariello, Giuseppe Aprile, Maria Renne, Bernardo Bonanni. 10-year results of a phase 3 trial of low-dose tamoxifen in non-invasive breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr GS4-08.

e4944059The present research, of a qualitative nature, aimed to identify, in the opinion of future Mathematics teachers in initial training, how the educational practice of using Digital Information and Communication Technologies (TDIC) in Mathematics teaching occurred while studying in Basic Education. The subjects, at the time of the research, were taking the first year of the Mathematics Degree course at a public university in Paraná, on four different campuses. For data collection, a questionnaire was answered by 71 subjects and three of them participated in an interview to complement the information. The analyzes were supported by the Discursive Textual Analysis, which culminated in the creation of three categories, one related to the form and difficulties in the use of TDIC, another to the advantages in the use of these resources and the third to reasons pointed out by the subjects for not using digital technologies in their Mathematics classes, as students. The results show that only 14 subjects had contact with TDIC in Basic Education and that among these, 11 consider that the use of these technologies for teaching has brought benefits to their understanding of the contents, turning the classes more dynamic and attractive. The subjects reported that several teachers had difficulties in using the TDIC.ResumoA presente pesquisa, de cunho qualitativo, teve como objetivo identificar, na opinião de futuros professores de Matemática em formação inicial, como ocorreu a prática educativa do uso das Tecnologias Digitais da Informação e Comunicação (TDIC) no ensino de Matemática, enquanto estudavam na Educação Básica. Os sujeitos, no momento de realização da pesquisa, cursavam o primeiro ano do curso de Licenciatura em Matemática em uma universidade pública paranaense em quatro campi diferentes. Para a coleta de dados, um questionário foi respondido por 71 sujeitos, dos quais três participaram de uma entrevista para complementar as informações. As análises foram apoiadas na Análise Textual Discursiva, que culminou na criação de três categorias, uma relacionada à forma e dificuldades na utilização das TDIC, outra às vantagens no uso desses recursos e a terceira aos motivos apontados pelos sujeitos para a não utilização de tecnologias digitais em suas aulas de Matemática, enquanto alunos. Os resultados evidenciam que apenas 14 sujeitos tiveram contato com as TDIC na Educação Básica, e que, dentre esses, 11 consideram que o uso dessas tecnologias para o ensino trouxe benefícios para sua compreensão dos conteúdos, tornando as aulas mais dinâmicas e atrativas. Os sujeitos relataram que diversos professores possuíam dificuldades em utilizar as TDIC.ResumenLa presente investigación, de carácter cualitativo, tuvo como objetivo identificar, a juicio de los futuros docentes de Matemáticas en formación inicial, cómo se da la práctica educativa del uso de las Tecnologías de la Información y la Comunicación Digitales (TDIC) en la enseñanza de las Matemáticas mientras cursaban estudios de Educación Básica. Los sujetos, en el momento de la investigación, cursaban el primer año de la carrera de Licenciatura en Matemáticas en una universidad pública de Paraná, en cuatro campus diferentes. Para la recolección de datos, 71 sujetos respondieron un cuestionario y tres de ellos participaron en una entrevista para complementar la información. Los análisis se apoyaron en el Análisis Textual Discursivo, que culminó con la creación de tres categorías, una relacionada con la forma y dificultades en el uso del TDIC, otra con las ventajas en el uso de estos recursos y la tercera con las razones señaladas por los sujetos para no utilizar tecnologías digitales en sus clases de matemáticas como estudiantes. Los resultados muestran que solo 14 sujetos tuvieron contacto con TDIC en Educación Básica, y que, de estos, 11 consideran que el uso de estas tecnologías para la docencia ha traído beneficios a la comprensión de los contenidos, ha hecho las clases más dinámicas y atractivas. Los sujetos informaron que varios profesores tenían dificultades para utilizar el TDIC.Palavras-chave: Ensino de Matemática, Opinião de professores em formação, Tecnologias Digitais, Uso pedagógico das TDIC.Keywords: Mathematics teaching, Opinion of teachers in formation, Digital Technologies, Pedagogical use of TDIC.Palabras claves: Enseñanza de las matemáticas, Opinión de docentes en formación, Tecnologías digitales, Uso pedagógico de TDIC.ReferencesALMEIDA, Caroline Medeiros Martins et al. Propostas de metodologias ativas usando tecnologias digitais e ferramentas metacognitivas para assistir no processo de ensino e aprendizagem: Revista del Centro de Investigaciones Educacionales Paradigma, Venezuela, 40(1), 204-220, mai. 2019. Disponível em: http://revistaparadigma.online/ojs/index.php/paradigma/article/view/748/744. Acesso em: ago. 2020.AMORIM, Myrna Cecília Martins dos Santos et al. Aprendizagem e Jogos: diálogo com alunos do ensino médio-técnico. Educação Realidade, Porto Alegre, 41(1) 91-115, jan. 2016. Disponível em:http://www.scielo.br/pdf/edreal/v41n1/2175-6236-edreal-41-01-00091.pdf. Acesso em: out. 2020.ANTUNES, Victor Hugo Ricco Bone; CIBOTTO, Rosefran Adriano Gonçales. Tecnologias da Informação e Comunicação: Um Diagnóstico acerca de seu uso por docentes de Matemática. Educação Matemática em Revista, Rio Grande do Sul, v.1, n.19, p. 80-92, 2018. Disponível em: http://sbem.iuri0094.hospedagemdesites.ws/revista/index.php/EMR-RS/article/view/1596/1070. Acesso em: 12 fev. 2020.BAIRRAL, Marcelo A. As TIC e a Licenciatura em Matemática: em defesa de um currículo focado em processos. Jornal Internacional de Estudos em Educação Matemática, São Paulo, v. 6, n. 1, 2013. Disponível em: http://periodicos.uniban.br/index.php?journal=JIEEMpage=articleop=viewpath%5B%5D=311path%5B%5D=352. Acesso em: out. 2020.BITTAR, Marilena. A abordagem instrumental para o estudo da integração da tecnologia na prática pedagógica do professor de matemática. Educar em Revista, Curitiba, n. Especial (1), 157-171, 2011. Editora UFPR. Disponível em: http://www.scielo.br/pdf/er/nse1/11.pdf. Acesso em: out. 2020.BORBA, Marcelo de Carvalho; PENTEADO, Mariam Godoy. Informática e Educação Matemática. 5. ed. Belo Horizonte, MG: Autêntica, 2012.BRASIL. Ministério da Educação. Secretaria de Educação a Distância. Programa Nacional de Informática na Educação. Brasília: Ministério da Educação e Cultura/Banco Interamericano de Desenvolvimento, 1997.BUENO, Carolina Soares; SANTOS, Luciane Mulazani dos. O uso de tecnologia nos anos iniciais do Ensino Fundamental na perspectiva da alfabetização matemática. Simpósio Educação Matemática em Debate, Joinville, SC, 136-148, 2014, Anais [...].. Disponível em:http://www.revistas.udesc.br/index.php/matematica/article/view/4746. Acesso em: out. 2020.CARNEIRO, Reginaldo Fernando; PASSOS, Cármen Lúcia Brancaglion. As Concepções de Professores de Matemática em Início de Carreira sobre as Contribuições da Formação Inicial para a Utilização das Tecnologias de Informação e Comunicação. Bolema, Rio Claro, 23(36), 775-800, 2010. Disponível em: http://www.periodicos.rc.biblioteca.unesp.br/index.php/bolema/article/view/4040/3278. Acesso em: out. 2020.COSTA, Vinícius Vieira; MEDEIROS, Miguel Araújo. Concepções de professores do Ensino Médio sobre a internet. In: VII Encontro Nacional de Pesquisa em Educação em Ciências, 7., 2009, Florianópolis, SP. Anais... Florianópolis. Disponível em: http://posgrad.fae.ufmg.br/posgrad/viienpec/pdfs/1003.pdf. Acesso em: out. 2020.FELCHER, Carla Denize Ott; PINTO, Ana Cristina; FOLMER, Vanderlei. Tendências em Tecnologias digitais no Ensino da Matemática Reveladas no EBRAPEM. Educação Matemática Pesquisa, v. 21, n. 2, 2019. Disponível em: https://revistas.pucsp.br/index.php/emp/article/download/39080/pdf. Acesso em: jan. 2021.FONSECA, Elias Antônio Almeida d; BARRÉRE, Eduardo. Possibilidades e desafios na utilização e seleção de TDIC para o ensino de Matemática em escolas públicas. In: VI Congresso Internacional de ensino de Matemática, 6. Canoas, RS. Anais... Canoas: ULBRA, 2013. Disponível em: http://www.conferencias.ulbra.br/index.php/ciem/vi/paper/viewFile/1343/568. Acesso em: set. 2020.LÖBLER, Mauri Leodir; PRETTO, Diego; BOLZAN, Larissa Medianeira. Percepção dos Alunos a respeito da Inclusão de Tecnologias Digitais no Ensino Público. CINTED – UFRG. Novas Tecnologias na educação, 11(3), 1-10, 2013. Disponível em: https://seer.ufrgs.br/index.php/renote/article/viewFile/44429/28141. Acesso em: set. 2020.MENEZES, Natércia do Céu Andrade Pesqueira. Motivação de alunos com e sem utilização das TIC em sala de aula. 2012. Dissertação (Mestrado em Inovação Ciência e Tecnologia) - Universidade Porticalense, Porto, Portugal. 2012. Disponível em: http://repositorio.uportu.pt/xmlui/handle/11328/516. Acesso em: out. 2020.MORAES, Roque. Uma tempestade de luz: a compreensão possibilitada pela análise textual discursiva. Revista Ciência e Educação, 9(2), 191-211, 2003. Disponível em: http://www.scielo.br/pdf/ciedu/v9n2/04.pdf. Acesso em: set. 2020.NOGUEIRA, Luana Karinne da Costa et al. Formação de professores e tecnologias da informação e comunicação – TIC: uma relação necessária para o uso de recursos tecnológicos na educação. In: X Congresso Brasileiro de Ensino Superior a Distância, 10., 2013, Belém, PA. Anais... Belém: UNIREDE, 2013. CD-ROM.PAIVA, Natália Moraes Nolêto de; COSTA, Johnatan da Silva. A influência da tecnologia na infância: desenvolvimento ou ameaça? Psicologia.PT – O portal dos psicólogos, 2015. Disponível em: https://www.psicologia.pt/artigos/textos/A0839.pdf. Acesso em: out. 2020.PARANÁ. Paraná digital: tecnologias de informação e comunicação nas escolas públicas paranaenses. Secretaria de Estado da Educação. Curitiba: SEED/PR, 2010.SANT’ANA, Claudinei de Camargo; AMARAL, Rúbia Barcelos; BORBA, Marcelo de Carvalho. O uso de softwares na prática profissional do professor de matemática. Ciência Educação, Bauru, v. 18, n. 03, ago. 2012. Disponível em: http://educa.fcc.org.br/pdf/ciedu/v18n03/v18n03a03.pdf. Acesso em: out. 2020.SCHLÜNZEN Junior, Klaus. Formação docente, gestão e tecnologias: desafios para a escola. Gestão Escolar - Gestão da Informação, Presidente Prudente, 4, 15-22, 2013. Disponível em: https://acervodigital.unesp.br/bitstream/123456789/65945/1/u1_d30_v4_t01.pdf. Acesso em: ago. 2020.SILVA, Raquel Silveira da; GAUTÉRIO, Vanda Leci Bueno. Práticas Multidisciplinares: Atividades Lúdicas e Tecnologia Digital aliada ao estudo de Artes e Geometria. RELACult - Revista Latino-Americana de Estudos em Cultura e Sociedade, v. 5, n. 4, 2019. Disponível em: https://www.claec.org/periodicos/index.php/relacult/article/download/1253/920. Acesso em: jan. 2021.SILVA, Raquel Silveira da; NOVELLO, Tanise Paula. O uso das tecnologias digitais no ensinar matemática: recursos, percepções e desafios. RELACult-Revista Latino-Americana de Estudos em Cultura e Sociedade, v. 6, n. 4, 2020. Disponível em: https://periodicos.claec.org/index.php/relacult/article/download/1733/1159. Acesso em: jan. 2021.SOUZA, Isabel Maria Amorim de; SOUZA, Luciana Virgília Amorim de. O uso da tecnologia como facilitadora da aprendizagem do aluno na escola. Revista Fórum Identidades, Itabaiana: GEPIADDE, 8(4), 127-142, 2010. Disponível em: http://atividadeparaeducacaoespecial.com/wp-content/uploads/2014/08/USO-DA-TECNOLGIA.pdf. Acesso em: set. 2020.

e4912046This scoping exploratory review was aimed at analyzing the challenges that the so-called post-truth world represents for teaching in Ibero-Latin American higher education. With the increased access to online information media and social networks, netizens are increasingly exposed and may be more vulnerable to false or misleading information that seeks to generate action from emotions rather than reason (GOSWAMI, 2017, Chronicle of Higher Education). The reference search was carried out in the databases of SciELO and La Referencia, from which 26 titles out of 196 were selected. Combinations of terms such as social media, post-truth, fake news, fact-checking, education, higher education, university, teaching, critical thinking, and freedom of expression were used, with the Boolean “Y” connector. The analysis of the references resulted in six thematic categories: main concepts; realms of fake news; news verification initiatives and methods; theoretical analysis and its relationship with education; studies on the factors, perception and credibility of fake news; and addressing misinformation in higher education. The discussion presents the draft of a proposed pedagogical model to be used in higher education and to address misinformation. Includes: critical thinking habits, democratic dialogue, intellectual skepticism, research skills, use of reliable sources of information, and analysis from multiple perspectives.ResumoEsta revisão exploratória de escopo teve como objetivo analisar os desafios que o chamado mundo pós-verdade representa para o ensino na educação superior ibero-americana. Com o aumento do acesso às mídias de informação online e redes sociais, os internautas estão cada vez mais expostos e podem ficar mais vulneráveis a informações falsas ou enganosas que buscam gerar ações a partir de emoções ao invés da razão (GOSWAMI, 2017, Chronicle of Higher Education). A busca das referências foi realizada nas bases de dados SciELO e La Referencia, das quais foram selecionados 26 títulos em 196. Combinações de termos como mídia social, pós-verdade, notícias falsas, checagem de fatos, educação, ensino superior, universidade, ensino, pensamento crítico e liberdade de expressão foram usadas, com o conector booleano “Y”. A análise das referências resultou em seis categorias temáticas: conceitos principais; escopos de notícias falsas; iniciativas e métodos de verificação de notícias; análise teórica e sua relação com a educação; estudos sobre os fatores, percepção e credibilidade das notícias falsas; e aproximação a desinformação no ensino superior. A discussão apresenta o esboço de uma proposta de modelo pedagógico para ser usado no ensino superior e para lidar com a desinformação. Inclui: hábitos de pensamento crítico, diálogo democrático, ceticismo intelectual, habilidades de pesquisa, uso de fontes confiáveis de informação e análise de múltiplas perspectivas.ResumenEsta revisión exploratoria de alcance tuvo como fin analizar los desafíos que para la enseñanza en la educación superior iberoamericana representa lo que se denomina el mundo posfactual (post-truth). Con el incrementado acceso a medios de información en línea y las redes sociales, los cibernautas están cada vez más expuestos y pueden ser más vulnerables a información falsa o engañosa que busca generar acción a partir de las emociones antes que la razón (GOSWAMI, 2017, Chronicle of Higher Education). La búsqueda de referencias se efectuó en las bases de datos de SciELO y La Referencia, de la cual se seleccionaron 26 títulos de 196. Se usaron combinaciones de términos como redes sociales, posverdad, noticias falsas, verificación de hechos, educación, educación superior, universidad, enseñanza, pensamiento crítico y libertad de expresión, con el conector booleano “Y”. El análisis de las referencias dio como resultado seis categorías temáticas: conceptos principales; ámbitos de las noticias falsas; iniciativas y métodos de verificación de noticias; análisis teóricos y su relación con la educación; estudios sobre factores, percepción y credibilidad de las noticias falsas; y abordaje de la desinformación en la educación superior. En la discusión se presenta el borrador de un modelo pedagógico propuesto para ser utilizado en la educación superior y abordar la desinformación. 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FIGURAS REVISTA ACADÉMICA DE INVESTIGACIÓN marca y construye –mediante un acto de escritura– la acción de transformar, delinear o representar en cada una de sus publicaciones, los hallazgos que los participantes plasman en cada una de las tres secciones contempladas en esta publicación. El comienzo de un nuevo volumen (segundo) para la revista estuvo enmarcado por el pensamiento, reflexión y señalamientos de saberes o aconteciminetos relacionados con el campo de conocimiento jurídico en la sección de ensayo. Perspectivas (Sección que reúne artículos de investigación originales e inéditos). En primer lugar de nuestras perspectivas de investigación presentamos Utopías sonoras: escollos y peligros de músicas idealizadas de Ricardo Miranda nos muestra el papel que jugó la música en la Utopía de Tomás Moro. En segundo lugar, las Exploraciones y reconstrucciones en Teotihuacan 1960-1962: intervenciones previas al “Proyecto Teotihuacán” de José Humberto Medina-González, una investigación que presenta hallazgos hacia una recuperación de una identidad territorial. Escenas (Sitio donde se configura una representación de la figuralización con un tema particular). La mirada de Alicia Florrick: Sobre The Good Wife y la necesaria feminización de la abogacía de Juan Jesús Garza-Onofre es una aproximación al papel de la mujer en el mundo jurídico desde una perspectiva moderna a apartir de una serie de televisión en streaming; El derecho internacional de los derechos culturales de Erika Flores-Déleon reflexiona sobre la importancia de visibilizar y nombrar uno de los derechos más importantes de la humanidad: la cultura; Las prisiones y sus consecuencias de Paola Zavala-Saeb cuestiona la administración de las prisiones en México y si llevan a cabo sus objetivos de reinserción social como mandato constitucional; mientras que Justicia ambiental: Un camino hacia la deconstrucción de los derechos de propiedad de Alma Rocío Segoviano-Basurto, es el primer ensayo que la revista publica en lengua inglesa, y aborda uno de los temas primordiales de la agenda internacional en temas de derecho: el ambiental. Resonancias (Sección que recoge reseñas críticas). Intercambios Oceánicos–México. Trazando redes de información global en repositorios de periódicos históricos, 1840-1914 de Rocío Castellanos-Rueda es la reseña de un proyecto internacional que brinda una perspectiva novedosa en el trabajo con repositorios digitales de distintos países; La intensidad vital del último estridentista de Daniel Téllez nos muestra el papel que jugó Germán List Arzubide en una vanguardia que, aunque efímera, se ocupó de los anhelos que el México posrevolucionario tenía de reivindicación social a partir de un movimiento literario. Por su parte, Que nunca nos falte la poesía: alto vuelo, alta vida a ‘Altazor’ de Marco Antonio Bojorquez-Martínez es la reseña de una revista literaria chilena que rinde homenaje al poeta chileno, Vicente Huidobro, publicando poesía latinoamericana. Dimensiones de la cultura literaria en México (1800-1850). Modelos de sociabilidad, materialidades, géneros y tradiciones intelectuales de Gamaliel Valentín-González reseña un libro que muestra los múltiples factores que influyeron en la conformación de la cultura literaria mexicana durante la primera mitad del siglo XIX e inaugura una Historia de las literaturas en México (colección de 6 volúmenes impulsada por la UNAM, entre otras instituciones ). Finalmente, La ciencia hecha poesía. ‘Principa’ de Elisa Díaz Castelo de Alejandro Rodríguez es una reseña del libro de poemas de la poeta que logra mezclar un lenguaje científico con el poético con un gran acierto, novedad y creatividad. FIGURAS REVISTA ACADÉMICA DE INVESTIGACIÓN proporciona acceso libre e inmediato a su contenido para hacer disponibles gratuitamente los artículos de investigación, ensayos y reseñas con la finalidad de sumarse al impulso que la Universidad Autónoma de México está dando al intercambio del contenido de las investigaciones que se llevan a cabo en el país, mediante el modelo del Acceso Abierto (OA: Open Access por sus siglas en inglés), entendido como una forma de compartir información científica sin costo o restricción para el usuario y en el que cada Artículo, Ensayo o Reseña figura de manera singular.

Coronary and peripheral artery diseases result in vessel occlusion and ischemia, initiating neovascularization to restore blood flow and preserve function. We previously demonstrated that osteopontin (OPN), a secreted cytokine, is critical to ischemia‐induced neovascularization. Unlike rodents, humans express 3 OPN isoforms (a, b, and c); however, the roles of these isoforms in neovascularization and cell migration remain undefined. To investigate if human OPN isoforms have differential effects on functional perfusion recovery in vivo, OPN−/− mice underwent hind limb ischemia (HLI) and received 1.5×106 lentivirus particles expressing OPNa, OPNb or OPNc at the time of surgery by intramuscular (IM) injection of the adductor muscle using a microsyringe. By utilizing this experimental approach, the only OPN in the system is what we add back, thus allowing us to determine how each human OPN isoform functions to influence neovascularization in vivo. OPNa and OPNc significantly improved limb perfusion, as measured by laser Doppler perfusion imaging, by 30.4%±0.8 and 70.9%±6.3, respectively (d14; p<0.001 vs. LVGFP, p<0.05 vs. hOPNb), and we confirmed by ELISA that these effects were not due to different protein expression levels (n=6, p=ns). OPNa and OPNc rescued limb function compared to control and OPNb‐treated animals (61.1%±8.2; 76.2%±9.7; p<0.05), as assessed by voluntary running wheel use. Additionally, OPNa and OPNc‐treated animals exhibit significant increases in arteriogenesis and macrophage infiltration in vivo (n=4, p<0.05 vs. GFP, OPNb). Therefore, we further hypothesized that divergent effects of OPN isoforms on arteriogenesis are due to differential effects on macrophage migration, survival, and/or polarization. Although OPN isoforms had no differential effects on macrophage polarization in vitro, OPN isoforms did differentially promote microphage migration in vitro, assessed using a modified Boyden chamber assay. While OPNa and OPNc both increased macrophage migration in vitro, OPNc was a more potent migratory stimulus than OPNa and OPNb in vitro (n=4, p<0.001 vs. no trx, OPNa, OPNb, and MCP‐1), consistent with what was observed in vivo. To determine if OPN isoforms have divergent effects on macrophage survival in vitro, OPN−/− macrophages were serum‐deprived to induce apoptosis and treated with recombinant OPNa, OPNb or OPNc proteins in vitro. Survival was assessed by FACS using FITC‐annexin V and propidium iodide staining. All isoforms significantly increased macrophage survival compared to no treatment, with OPNc increasing survival significantly greater than OPNa and OPNb (n=4, p<0.05 vs. OPNb, p<0.001 vs. no trx, and OPNa). In conclusion, human OPN isoforms exhert divergent effects on neovascularization through differential effects on arteriogenesis and macrophage infiltration in vivo and differential direct effects on Macrophage migration and survival, but not polarization, in vitro. Taken together, these data support that human OPN isoforms may represent novel therapeutic targets to improve neovascualrization and preserve tissue function in patients with obstructive artery diseases.Support or Funding Information1. T32 Training Grant #T32HL007745, NIH/NHLBI, W. Robert Taylor (PI), 01/03/2016 to present: Research Training in Academic Cardiology (Role: Post‐doctoral trainee) The goal of this training grant is to support for the highly successful postdoctoral training program in cardiovascular research in the Division of Cardiology at Emory University School of Medicine. The training program is structured around a mentor‐based environment supplemented with an extensive array of didactic educational opportunities for multidisciplinary training in basic and clinical vascular biology. Successful trainees will be well‐equipped to initiate a research career in academic cardiology. 2. K99/R00 HL119567, NIH/NHLBI, Alicia N.Lyle (PI), 04/2014–06/2019: The Role of Human Osteopontin Isoforms in Collateral Formation This project uses a novel translational therapeutic strategy to determine how the different human osteopontin (OPN) isoforms influence collateral formation.

Editorial PhD. Marianela Morales Calatayud Impacto de la deducibilidad de gastos personales en la recaudación tributaria Katherine del Cisne Guamarriga Valdez, Ruth Maryury Delgado Olaya, Armando José Urdaneta Montiel La experiencia de la educación por radio en Panamá Víctor Manuel Álvarez Franco Trombofilia hereditaria (Mutación C677t en estado heterocigótico del gen de la enzima Metilentetrahidrofolatoreductasa). Presentación de un caso Aimé María Reyes Pérez, Práxedes de Regla Rojas Quintana, Elodia María Rivas Alpízar, Aida María Reyes Pérez La sanción administrativa de destitución por error inexcusable vulnera la independencia del juez Juan Alcívar Sarango Rodríguez La búsqueda de información científica en las bases de datos académicas Eudaldo Enrique Espinoza Freire Especies vegetales vasculares acuáticas de la laguna la tembladera, provincia El Oro, Ecuador Milton Luis Cun Jaramillo, Víctor Manuel Figueroa, Darío Javier Dueñas Alvarado Las redes de conocimientos: bases de una alternativa metodológica para la investigación sobre la sostenibilidad ambiental en el Ecuador. Marianela de la Caridad Morales Calatayud, Roberto Yasiel García Dueñas, Carlos Hernández Morales Rutas inmersivas de Realidad Virtual como alternativa tecnológica en el proceso educativo Fernando Juca Maldonado, Jéssica Lalangui Ramírez, María Isabel Bastidas Andrade La diversidad cultural y la problemática con el bullying en el ámbito de la Educación Básica Eimy Eliana Espinoza Guamán, Adriana Lorena Reyes Heras, María Alexandra Galarza Valarezo Análisis de un modelo sistémico arquetípico para la validación de un proyecto arquitectónico José Manuel Donado Aspectos sociales y económicos: caso productores de café en la provincia El Oro Carlos Vicente Castro Pincay, Salomón Barrezueta Unda Diagnóstico de la incidencia de Hematuria Enzoótica Bovina de bovinos en producción de tres zonas ganaderas Luis Miguel Mejía Pacheco, Inés Patricia Malo Cevallos La academia como agente del desarrollo local. Tonysé De la Rosa Martín, Adriano Ricardo Brivio Borja Las Tecnologías de la Información y la Comunicación y su avance en el contexto educativo Alizia Agnelli Faggioli La evaluación como proceso en la universidad del siglo XXI Elisa María Ríos Valoración de los aprendizajes extemporáneos y acelerados, salud de profesores universitarios y ayuda institucional Reinaldo Requeiro Almeida, Arturo Bofill Placeres El acoso callejero, una forma de violencia contra la mujer María Belén Fierro López, Pablo Joel López Jiménez, Libertad Machado López, Mariuxi Paola Cedeño Floril Desarrollo de habilidades cognitivas en lengua y literatura en quinto año de educación básica en Machala María Fernanda Ramón Guartatanga, Sonia Estefanía Ortega Sagbay, Eudaldo Enrique Espinoza Freire Agroturismo como alternativa para el desarrollo socioeconómico de la Parroquia Río Bonito Ignacio Efraín Mateo Burbano, Harry Vite Cevallos, Héctor Carvajal Romero La satisfacción laboral en la Universidad Metropolitana Sede Machala a través de la incidencia de la comunicación organizacional Janneth Rocío Yánez Sarmiento, Marisol Yánez Sarmiento Espacio Angolano para la Cooperación Interuniversitaria Yohandra Rad Camayd, Horacio Salvado Hernández Vinculación hecho y deber social trabajo con el principio protector Alizia Agnelli Faggioli, Belkis Alida García El problema migratorio, un fenómeno global Marily Rafaela Fuentes Águila, Pedro Enrique Castellanos Fuentes Análisis prospectivo del paradigma para una nueva educación, un estudio del caso ecuatoriano Julio Paredes-Riera, Cristhian Paredes-Riera Evaluación de los índices de calidad del suelo de diversos cultivos en diferentes condiciones topográficas Jenner Barrera León, Salomón Barrezueta Unda, Rigoberto Miguel García Batista La discriminación en los salones de clase Verónica Jacqueline Guamán Gómez, Oscar Rodolfo Serrano Polo, Ximena del Rocío Sánchez Barreto Caracterización morfoagronómica de 27 accesiones de maní (Arachis Hypogaea L) Maria Lisbeht Blacio, Ivanna Gabriela Tuz Guncay, José Nicasio Quevedo Guerrero, Rigoberto Miguel García Batista Una incursión al Modelo Triple Hélice, visto desde la Universidad Metropolitana del Ecuador María del Carmen Franco Gómez, Greicy de la Caridad Rodríguez Crespo

La Universidad Tecnológica Nacional - Facultad Regional Córdoba (UTN-FRC), junto con la Asociación Argentina de Materiales (SAM), ha organizado el 8vo. Encuentro de Jóvenes Investigadores en Ciencia y Tecnología de Materiales JIM 2023, el cual se llevó a cabo los días 7 y 8 de septiembre de 2023.Este encuentro, propició la interacción entre jóvenes investigadores en materiales de distintas partes del país, fomentando la colaboración, el intercambio de ideas, experiencias y conocimientos. Además, este espacio, presentó grandes oportunidades para dar a conocer los distintos temas de trabajo y establecer lazos con otros jóvenes estudiantes y/o profesionales, desde los inicios de sus carreras de grado y posgrado, ya sea desde el ámbito público como privado. La presentación de trabajos durante el encuentro fue en forma de pósteres, con tiempos asignados para la defensa de los mismos ante un jurado. Luego, se otorgaron premios para los postulantes en diferentes categorías. Además, los asistentes participaron en conferencias plenarias, dictadas por oradores de importante trayectoria, pertenecientes a distintas áreas del estudio de materiales; tanto del ámbito académico como industrial.Desde el comité organizador, agradecemos la participación de los asistentes, expositores, disertantes, auspiciantes y a cada uno de los que trabajaron arduamente para la realización de esta 8va. edición del encuentro. COMITÉ ORGANIZADOR Presidente del comité organizador Dr. Ing. Roberto Oscar Lucci (Dpto. de Ing. Metalúrgica, UTN-FRC) Integrantes Ing. César Roure(Dpto. de Ing. Metalúrgica, UTN-FRC) Ing. Santiago Cantero(Dpto. de Ing. Metalúrgica, UTN-FRC) Dra. Ing. Bárbara Belén Raggiotti(CINTEMAC, UTN-FRC) Mg. Ing. Adrián Segura(CINTEMAC, UTN-FRC) Dra. Ing. Verónica Elias(CITeQ, UTN-CONICET) Dra. Ing. Eliana Vaschetto(CITeQ, UTN-CONICET) COMITÉ CIENTÍFICO Presidente del comité científico Dra. Sonia Brühl(CONICET-GIS, UTN-FRCU) Integrantes Dra. Alicia Ares (CONICET-FCEQYN, UNAM) Dra. María Cecilia Marinelli (IFIR-CONICET, UNR) Dra. Ana Velia Druker (IFIR-CONICET, UNR) Dra. Eugenia Dalibón (GIS, UTN-FRCU) Dra. Ana Florencia Forte Giacobone (CAC-CNEA, UNTREF) Dr. Amadeo Daniel Sosa (INTEMA-CONICET, UNMdP) Dra. Silvana Sommadossi (CONICET-FI, UNCOMA) Dr. Ing. Roberto Oscar Lucci (Dpto. de Ing. Metalúrgica, UTN-FRC) Dra. Ing. Verónica Elias (CITeQ, UTN-CONICET) Dra. Ing. Eliana Vaschetto (CITeQ, UTN-CONICET) Dra. Ing. Bárbara Belén Raggiotti (CINTEMAC, UTN-FRC) Mg. Ing. Adrián Segura (CINTEMAC, UTN-FRC) Dr. Ing. Luciano Grinschpun (FCEFyN-UNC) Dra. Ing. Candelaria Leal Marchena (CITeQ, UTN-CONICET) Dra. Romina Ollier (INTEMA-CONICET) Dra. Laura Lerici (CITeQ, UTN-CONICET) Dra. Carla Fermanelli (CITeQ, UTN-CONICET) Dra. Ing. Liliana Pierella (CITeQ, UTN-CONICET) Dra. Paula Bercoff (FAMAF-UNC, IFEG-CONICET) Áreas temáticas Metales y Aleaciones Polímeros Cerámicos, Refractarios y Vidrios Procesamiento y caracterización de materiales Tecnología de Superficies, Tratamientos Térmicos y Transformaciones de Fases Soldadura y Fundiciones Simulaciones Materiales de Construcción Civil y Vial Materiales para Aplicaciones en Energía, Salud y Medio Ambiente Nanomateriales Industria Corrosión y Degradación Disertantes Dr. Gabriel Meyer(CNEA – CONICET) Mgtr. Hugo Mendieta(EOS GmbH – Electro Optical Systems) Dra. Paula Bercoff(FAMAF-UNC, IFEG-CONICET) Dr. Pablo Bejarano(PYROTEK INC.) Mgtr. Jerónimo Colazo(SUDOSILO S.A.) Ing. Alejandra Jewsbury(UTN-FRC) Dra. Nora Pellegri(IFIR-CONICET, UNR) Dra. Sonia Brühl(CONICET-GIS, UTN–FRCU)