Journal articles on the topic 'Electroactive hydrogel'

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1

Shang, Jing, Zhengzhong Shao, and Xin Chen. "Chitosan-based electroactive hydrogel." Polymer 49, no. 25 (November 2008): 5520–25. http://dx.doi.org/10.1016/j.polymer.2008.09.067.

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2

Jayaramudu, Tippabattini, Hyun-U. Ko, Hyun Kim, Jung Kim, Ruth Muthoka, and Jaehwan Kim. "Electroactive Hydrogels Made with Polyvinyl Alcohol/Cellulose Nanocrystals." Materials 11, no. 9 (September 4, 2018): 1615. http://dx.doi.org/10.3390/ma11091615.

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This paper reports a nontoxic, soft and electroactive hydrogel made with polyvinyl alcohol (PVA) and cellulose nanocrystal (CNC). The CNC incorporating PVA-CNC hydrogels were prepared using a freeze–thaw technique with different CNC concentrations. Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction and scanning electron microscopy results proved the good miscibility of CNCs with PVA. The optical transparency, water uptake capacity and mechanical properties of the prepared hydrogels were investigated in this study. The CNC incorporating PVA-CNC hydrogels showed improved displacement output in the presence of an electric field and the displacement increased with an increase in the CNC concentration. The possible actuation mechanism was an electrostatic effect and the displacement improvement of the hydrogel associated with its enhanced dielectric properties and softness. Since the prepared PVA-CNC hydrogel is nontoxic and electroactive, it can be used for biomimetic soft robots, actively reconfigurable lenses and active drug-release applications.
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Guan, Shui, Yangbin Wang, Feng Xie, Shuping Wang, Weiping Xu, Jianqiang Xu, and Changkai Sun. "Carboxymethyl Chitosan and Gelatin Hydrogel Scaffolds Incorporated with Conductive PEDOT Nanoparticles for Improved Neural Stem Cell Proliferation and Neuronal Differentiation." Molecules 27, no. 23 (November 29, 2022): 8326. http://dx.doi.org/10.3390/molecules27238326.

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Tissue engineering scaffolds provide biological and physiochemical cures to guide tissue recovery, and electrical signals through the electroactive materials possess tremendous potential to modulate the cell fate. In this study, a novel electroactive hydrogel scaffold was fabricated by assembling poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles on a carboxymethyl chitosan/gelatin (CMCS/Gel) composite hydrogel surface via in situ chemical polymerization. The chemical structure, morphology, conductivity, porosity, swelling rate, in vitro biodegradation, and mechanical properties of the prepared hydrogel samples were characterized. The adhesion, proliferation, and differentiation of neural stem cells (NSCs) on conductive hydrogels were investigated. The CMCS/Gel-PEDOT hydrogels exhibited high porosity, excellent water absorption, improved thermal stability, and adequate biodegradability. Importantly, the mechanical properties of the prepared hydrogels were similar to those of brain tissue, with electrical conductivity up to (1.52 ± 0.15) × 10−3 S/cm. Compared to the CMCS/Gel hydrogel, the incorporation of PEDOT nanoparticles significantly improved the adhesion of NSCs, and supported long-term cell growth and proliferation in a three-dimensional (3D) microenvironment. In addition, under the differentiation condition, the conductive hydrogel also significantly enhanced neuronal differentiation with the up-regulation of β-tubulin III expression. These results suggest that CMCS/Gel-PEDOT hydrogels may be an attractive conductive substrate for further studies on neural tissue repair and regeneration.
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4

O’Grady, Megan L., Po-ling Kuo, and Kevin Kit Parker. "Optimization of Electroactive Hydrogel Actuators." ACS Applied Materials & Interfaces 2, no. 2 (December 23, 2009): 343–46. http://dx.doi.org/10.1021/am900755w.

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5

Shim, Woo Sun, and Doo Sung Lee. "Electroactive and temperature-sensitive hydrogel composites." Journal of Applied Polymer Science 74, no. 2 (October 10, 1999): 311–21. http://dx.doi.org/10.1002/(sici)1097-4628(19991010)74:2<311::aid-app12>3.0.co;2-b.

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6

Chen, Shuiliang, Fangfang Yang, Chungen Li, Suqing Zheng, Hua Zhang, Ming Li, Haimin Yao, Feng Zhao, and Haoqing Hou. "Encapsulation of a living bioelectrode by a hydrogel for bioelectrochemical systems in alkaline media." Journal of Materials Chemistry B 3, no. 23 (2015): 4641–46. http://dx.doi.org/10.1039/c5tb00563a.

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A hydrogel-bioelectrode was fabricated by encapsulating a living electroactive biofilm with a poly(vinyl alcohol) hydrogel through a freezing/thawing process for bioelectrochemical systems in alkaline media.
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7

Farooqi, Abdul Razzaq, Julius Zimmermann, Rainer Bader, and Ursula van Rienen. "Numerical Simulation of Electroactive Hydrogels for Cartilage–Tissue Engineering." Materials 12, no. 18 (September 9, 2019): 2913. http://dx.doi.org/10.3390/ma12182913.

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The intrinsic regeneration potential of hyaline cartilage is highly limited due to the absence of blood vessels, lymphatics, and nerves, as well as a low cell turnover within the tissue. Despite various advancements in the field of regenerative medicine, it remains a challenge to remedy articular cartilage defects resulting from trauma, aging, or osteoarthritis. Among various approaches, tissue engineering using tailored electroactive scaffolds has evolved as a promising strategy to repair damaged cartilage tissue. In this approach, hydrogel scaffolds are used as artificial extracellular matrices, and electric stimulation is applied to facilitate proliferation, differentiation, and cell growth at the defect site. In this regard, we present a simulation model of electroactive hydrogels to be used for cartilage–tissue engineering employing open-source finite-element software FEniCS together with a Python interface. The proposed mathematical formulation was first validated with an example from the literature. Then, we computed the effect of electric stimulation on a circular hydrogel sample that served as a model for a cartilage-repair implant.
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8

Tian, Kun, Zhengzhong Shao, and Xin Chen. "Natural Electroactive Hydrogel from Soy Protein Isolation." Biomacromolecules 11, no. 12 (December 13, 2010): 3638–43. http://dx.doi.org/10.1021/bm101094g.

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9

Gupta, Kriti, Ruchi Patel, Madara Dias, Hina Ishaque, Kristopher White, and Ronke Olabisi. "Development of an Electroactive Hydrogel as a Scaffold for Excitable Tissues." International Journal of Biomaterials 2021 (January 30, 2021): 1–9. http://dx.doi.org/10.1155/2021/6669504.

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For many cells used in tissue engineering applications, the scaffolds upon which they are seeded do not entirely mimic their native environment, particularly in the case of excitable tissues. For instance, muscle cells experience contraction and relaxation driven by the electrical input of an action potential. Electroactive materials can also deform in response to electrical input; however, few such materials are currently suitable as cell scaffolds. We previously described the development of poly(ethyelene glycol) diacrylate-poly(acrylic acid) as an electroactive scaffold. Although the scaffold itself supported cell growth and attachment, the voltage (20 V) required to actuate these scaffolds was cytotoxic. Here, we describe the further development of our hydrogels into scaffolds capable of actuation at voltages (5 V) that were not cytotoxic to seeded cells. This study describes the critical next steps towards the first functional electroactive tissue engineering scaffold.
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10

Kumar, Vijayesh, Abhay Sachdev, and Ishita Matai. "Self-assembled reduced graphene oxide–cerium oxide nanocomposite@cytochrome c hydrogel as a solid electrochemical reactive oxygen species detection platform." New Journal of Chemistry 44, no. 26 (2020): 11248–55. http://dx.doi.org/10.1039/d0nj02038a.

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11

Pons, Carolina, Josué M. Galindo, Juan Carlos Martín, Iván Torres-Moya, Sonia Merino, María Antonia Herrero, Ester Vázquez, Pilar Prieto, and Juan Antonio Vallés. "Guiding losses estimation in hydrogel-based waveguides." Journal of Physics: Conference Series 2407, no. 1 (December 1, 2022): 012032. http://dx.doi.org/10.1088/1742-6596/2407/1/012032.

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Abstract A method based on the photographic recording of the power distribution laterally diffused by cationic electroactive network (CN)-based hydrogel waveguides is first checked against the well-established cut-back method and then used to determine the different contributions to the optical power attenuation along the hydrogel-based waveguide. Absorption and scattering loss coefficients are determined for 450 nm, 532 nm and 633 nm excitation.
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12

Guillot-Ferriols, Maria, María Inmaculada García-Briega, Laia Tolosa, Carlos M. Costa, Senentxu Lanceros-Méndez, José Luis Gómez Ribelles, and Gloria Gallego Ferrer. "Magnetically Activated Piezoelectric 3D Platform Based on Poly(Vinylidene) Fluoride Microspheres for Osteogenic Differentiation of Mesenchymal Stem Cells." Gels 8, no. 10 (October 20, 2022): 680. http://dx.doi.org/10.3390/gels8100680.

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Mesenchymal stem cells (MSCs) osteogenic commitment before injection enhances bone regeneration therapy results. Piezoelectric stimulation may be an effective cue to promote MSCs pre-differentiation, and poly(vinylidene) fluoride (PVDF) cell culture supports, when combined with CoFe2O4 (CFO), offer a wireless in vitro stimulation strategy. Under an external magnetic field, CFO shift and magnetostriction deform the polymer matrix varying the polymer surface charge due to the piezoelectric effect. To test the effect of piezoelectric stimulation on MSCs, our approach is based on a gelatin hydrogel with embedded MSCs and PVDF-CFO electroactive microspheres. Microspheres were produced by electrospray technique, favouring CFO incorporation, crystallisation in β-phase (85 %) and a crystallinity degree of around 55 %. The absence of cytotoxicity of the 3D construct was confirmed 24 h after cell encapsulation. Cells were viable, evenly distributed in the hydrogel matrix and surrounded by microspheres, allowing local stimulation. Hydrogels were stimulated using a magnetic bioreactor, and no significant changes were observed in MSCs proliferation in the short or long term. Nevertheless, piezoelectric stimulation upregulated RUNX2 expression after 7 days, indicating the activation of the osteogenic differentiation pathway. These results open the door for optimising a stimulation protocol allowing the application of the magnetically activated 3D electroactive cell culture support for MSCs pre-differentiation before transplantation.
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13

Burrs, S. L., D. C. Vanegas, M. Bhargava, N. Mechulan, P. Hendershot, H. Yamaguchi, C. Gomes, and E. S. McLamore. "A comparative study of graphene–hydrogel hybrid bionanocomposites for biosensing." Analyst 140, no. 5 (2015): 1466–76. http://dx.doi.org/10.1039/c4an01788a.

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Graphene–nanometal enzymatic biosensors were prepared using hydrogels composed of chitosan, poly-N-isopropylacrylamide, silk fibroin, or cellulose nanocrystals. The comparative study investigated electroactive surface area, charge transfer, response time, limit of detection, and sensitivity toward alcohols.
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14

Yuan, Y. J., G. G. Wallace, R. John, and S. B. Adeloju. "Effective diffusion of electroactive species on hydrogel modified ultramicroelectrodes." Polymer Gels and Networks 6, no. 5 (October 1998): 383–91. http://dx.doi.org/10.1016/s0966-7822(98)00034-3.

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15

Pattavarakorn, Datchanee, Pornpun Youngta, Sutawan Jaesrichai, Siripong Thongbor, and Pikulthong Chaimongkol. "Electroactive Performances of Conductive Polythiophene/hydrogel Hybrid Artificial Muscle." Energy Procedia 34 (2013): 673–81. http://dx.doi.org/10.1016/j.egypro.2013.06.799.

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16

Usuki, Kodai, Hiroaki Onoe, and Eiji Iwase. "Flexible Coloring Element by using Bending Deformation of Electroactive Hydrogel." IEEJ Transactions on Sensors and Micromachines 135, no. 12 (2015): 480–83. http://dx.doi.org/10.1541/ieejsmas.135.480.

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17

Zhang, Danying, Feng Di, Yinyan Zhu, Yinghong Xiao, and Jianfei Che. "Electroactive hybrid hydrogel: Toward a smart coating for neural electrodes." Journal of Bioactive and Compatible Polymers 30, no. 6 (July 6, 2015): 600–616. http://dx.doi.org/10.1177/0883911515591647.

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18

Guan, T., F. Godts, F. Ceyssens, P. Dubruel, H. P. Neves, and R. Puers. "Micropatterning and dynamic swelling of photo-crosslinkable electroactive Pluronic hydrogel." Procedia Engineering 25 (2011): 856–59. http://dx.doi.org/10.1016/j.proeng.2011.12.210.

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19

USUKI, KODAI, HIROAKI ONOE, and EIJI IWASE. "Flexible Coloring Element by Using Bending Deformation of Electroactive Hydrogel." Electronics and Communications in Japan 100, no. 1 (December 13, 2016): 44–48. http://dx.doi.org/10.1002/ecj.11919.

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20

He, Lei, Demeng Lin, Yanping Wang, Yinghong Xiao, and Jianfei Che. "Electroactive SWNT/PEGDA hybrid hydrogel coating for bio-electrode interface." Colloids and Surfaces B: Biointerfaces 87, no. 2 (October 2011): 273–79. http://dx.doi.org/10.1016/j.colsurfb.2011.05.028.

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21

Zhu, Hui, Weitao Dai, Liming Wang, Cong Yao, Chenxi Wang, Bingsong Gu, Dichen Li, and Jiankang He. "Electroactive Oxidized Alginate/Gelatin/MXene (Ti3C2Tx) Composite Hydrogel with Improved Biocompatibility and Self-Healing Property." Polymers 14, no. 18 (September 19, 2022): 3908. http://dx.doi.org/10.3390/polym14183908.

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Conductive hydrogels (CHs) have shown promising potential applied as wearable or epidermal sensors owing to their mechanical adaptability and similarity to natural tissues. However, it remains a great challenge to develop an integrated hydrogel combining outstanding conductive, self-healing and biocompatible performances with simple approaches. In this work, we propose a “one-pot” strategy to synthesize multifunctional CHs by incorporating two-dimensional (2D) transition metal carbides/nitrides (MXenes) multi-layer nano-flakes as nanofillers into oxidized alginate and gelatin hydrogels to form the composite CHs with various MXene contents. The presence of MXene with abundant surface groups and outstanding conductivity could improve the mechanical property and electroactivity of the composite hydrogels compared to pure oxidized alginate dialdehyde-gelatin (ADA-GEL). MXene-ADA-GELs kept good self-healing properties due to the dynamic imine linkage of the ADA-GEL network and have a promoting effect on mouse fibroblast (NH3T3s) attachment and spreading, which could be a result of the integration of MXenes with stimulating conductivity and hydrophily surface. This study suggests that the electroactive MXene-ADA-GELs can serve as an appealing candidate for skin wound healing and flexible bio-electronics.
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22

Maher, Shaimaa, Haitham Kalil, and Mekki Bayachou. "Alginate/Polyethyleneimine-Based Nitric Oxide-Releasing Hydrogel As a Potential Platform to Study the Effects of NO on Carcinogenesis." ECS Meeting Abstracts MA2022-01, no. 55 (July 7, 2022): 2318. http://dx.doi.org/10.1149/ma2022-01552318mtgabs.

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Numerous biological functions are affected by the functions of nitric oxide (NO), such as cell proliferation and programmed cell death. NOis a ubiquitous free radical gas that exerts a wide range of biological effects and acts as a signaling molecule in the body. Recent studies have indicated that nitric oxide regulates multiple cancer-related processes, such as angiogenesis, apoptosis, cell cycle, invasion, and metastasis. Alternatively, it is also emerging as a potential anti-oncogenic agent under other conditions. Nitric oxide is synthesized by a complex family of nitric oxide synthase (NOS) enzymes. There is encouraging interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. The goal of this project is to develop a hydrogel that incorporates inducible nitric oxide synthase (iNOS) using a layer-by-layer building strategy to form layers of polyethyleneimine (PEI) and iNOSoxy as NO-releasing coatings on alginate hydrogel. When the hydrogel coated with PEI/iNOSoxy films are exposed to arginine, a source of reducing equivalents, and other required ingredients, nitric oxide is formed and released. In this work, FTIR spectroscopy was employed to characterize the functional groups of pristine sodium alginate (SA), polyethyleneimine (PEI) and SA/PEI composite hydrogels. We also used scanning electron microscopy (SEM) for surface characterization. Cyclic voltammetry was used to determine the amount of electroactive heme-enzyme adsorbed on the modified surfaces. We examine how the electroactive heme enzyme in the thin films correlates with the enzymatic NOS activity in terms of NO release fluxes from PEI/NOS-coated hydrogels. After the structural characterization of the NOS/hydrogel films using spectroscopy, we examined their function in terms of NO release profiles. We observed an initial “burst” of NO release during the first 4 hours of activity, followed by a decline and then stable NO release for up to 144 hours possibility to interrogate the role of NO on the balance of cell proliferation and cell death in these cell lines. The measured fluxes are higher than what have been reported in the literature for other inorganic NO-releasing systems. This data will allow us to build NOS-alginate hydrogels with defined NO release profiles for application in cell biology to test the effect of sustained NO release on cell proliferation and cell death on specific cancer cell lines.
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23

Usuki, Kodai, Hiroaki Onoe, and Eiji Iwase. "Deformable coloring element using an electroactive hydrogel with bottom-arranged electrodes." Japanese Journal of Applied Physics 54, no. 6S1 (April 27, 2015): 06FP06. http://dx.doi.org/10.7567/jjap.54.06fp06.

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24

Han, Daehoon, Cindy Farino, Chen Yang, Tracy Scott, Daniel Browe, Wonjoon Choi, Joseph W. Freeman, and Howon Lee. "Soft Robotic Manipulation and Locomotion with a 3D Printed Electroactive Hydrogel." ACS Applied Materials & Interfaces 10, no. 21 (May 9, 2018): 17512–18. http://dx.doi.org/10.1021/acsami.8b04250.

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25

Muya, Francis Ntumba, Xolani Terrance Ngema, Priscilla Gloria Lorraine Baker, and Emmanuel Iheanyichukwu Iwuoha. "Sensory Properties of Polysulfone Hydrogel for Electro-Analytical Profiling of Vanadium and Selenium in Aqueous Solutions." Journal of Nano Research 44 (November 2016): 142–57. http://dx.doi.org/10.4028/www.scientific.net/jnanor.44.142.

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Hydrogels have been a topic of extensive research because of their unique bulk and surface properties. They play a vital role in development of controlled release drug delivery systems. Polysulfone hydrogels are hydrophilic porous materials, which provide the advantage of biocompatibility and effective orientation of biomolecule in the design of the novel biosensors [1-2]. Polysulfone hydrogels may be prepared as water swellable powders or drop cast as thin films on screen printed carbon electrodes (SPCE). Polysulfone hydrogels produce electroactive thin films, characterized by 2 well resolved redox peaks, with a formal potential of 0.0867 V and diffusion coefficient in aqueous medium of 9.06e-9 Cm2/s. In this paper we report on the initial speciation studies and analytical performance of Selenium and Vanadium at the hydrogel electrodes, as evaluated by using cyclic voltammetry in a range of -0.7 V to +0.0 V versus Ag/AgCl. The morphology, adsorption and thin film integrity was evaluated using High resolution scanning electron microscopy (HR-SEM), UV-Vis and Raman spectroscopy.
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26

Bhat, Ankita, Alexa R. Graham, Hemang Trivedi, Matthew K. Hogan, Philip J. Horner, and Anthony Guiseppi-Elie. "Engineering the ABIO-BIO interface of neurostimulation electrodes using polypyrrole and bioactive hydrogels." Pure and Applied Chemistry 92, no. 6 (June 25, 2020): 897–907. http://dx.doi.org/10.1515/pac-2019-1107.

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AbstractFollowing spinal cord injury, the use of electrodes for neurostimulation in animal models has been shown to stimulate muscle movement, however, the efficacy of such treatment is impaired by increased interfacial impedance caused by fibrous encapsulation of the electrode. Sputter-deposited gold-on-polyimide electrodes were modified by potentiostatic electrodeposition of poly(pyrrole-co-3-pyrrolylbutyrate-conj-aminoethylmethacrylate): sulfopropyl methacrylate [P(Py-co-PyBA-conj-AEMA):SPMA] to various charge densities (0–100 mC/cm2) to address interfacial impedance and coated with a phosphoryl choline containing bioactive hydrogel to address biocompatibility at the ABIO-BIO interface. Electrodes were characterized with scanning electron microscopy (surface morphology), multiple-scan rate cyclic voltammetry (peak current and electroactive area), and electrochemical impedance spectroscopy (charge transfer resistance and membrane resistance). SEM analysis and electroactive area calculations identified films fabricated with a charge density of 50 mC/cm2 as well suited for neurostimulation electrodes. Charge transfer resistance demonstrated a strong inverse correlation (−0.83) with charge density of electrodeposition. On average, the addition of polypyrrole and hydrogel to neurostimulation electrodes decreased charge transfer resistance by 82 %. These results support the use of interfacial engineering techniques to mitigate high interfacial impedance and combat the foreign body response towards epidurally implanted neurostimulation electrodes.
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27

Ha, Eun-Ju, Bong-Soo Kim, Chun-ho Park, Jang-Oo Lee, and Hyun-jong Paik. "Electroactive hydrogel comprising poly(methyl 2-acetamido acrylate) for an artificial actuator." Journal of Applied Physics 114, no. 5 (August 7, 2013): 054701. http://dx.doi.org/10.1063/1.4815932.

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28

Marcisz, Kamil, Jan Romanski, Zbigniew Stojek, and Marcin Karbarz. "Environmentally sensitive hydrogel functionalized with electroactive and complexing-iron(III) catechol groups." Journal of Polymer Science Part A: Polymer Chemistry 55, no. 19 (June 29, 2017): 3236–42. http://dx.doi.org/10.1002/pola.28697.

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29

Kwon, Gu Han, Gi Seok Jeong, Joong Yull Park, Jin Hee Moon, and Sang-Hoon Lee. "A low-energy-consumption electroactive valveless hydrogel micropump for long-term biomedical applications." Lab on a Chip 11, no. 17 (2011): 2910. http://dx.doi.org/10.1039/c1lc20288j.

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30

Joo, Hyeonseo, Hoseong Han, and Sunghun Cho. "Fabrication of Poly(vinyl alcohol)-Polyaniline Nanofiber/Graphene Hydrogel for High-Performance Coin Cell Supercapacitor." Polymers 12, no. 4 (April 17, 2020): 928. http://dx.doi.org/10.3390/polym12040928.

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Electroactive polymer hydrogel offers several advantages for electrical devices, including straightforward synthesis, high conductivity, excellent redox behavior, structural robustness, and outstanding mechanical properties. Here, we report an efficient strategy for generating polyvinyl alcohol–polyaniline–multilayer graphene hydrogels (PVA–PANI–MLG HDGs) with excellent scalability and significantly improved mechanical, electrical, and electrochemical properties; the hydrogels were then utilized in coin cell supercapacitors. Production can proceed through the simple formation of boronate (–O–B–O–) bonds between PANI and PVA chains; strong intermolecular interactions between MLG, PANI, and PVA chains contribute to stronger and more rigid HDGs. We identified the optimal amount of PVA (5 wt.%) that produces a nanofiber-like PVA–PANI HDG with better charge transport properties than PANI HDGs produced by earlier approaches. The PVA–PANI–MLG HDG demonstrated superior tensile strength (8.10 MPa) and higher specific capacitance (498.9 F/cm2, 166.3 F/cm3, and 304.0 F/g) than PVA–PANI HDGs without MLG. The remarkable reliability of the PVA–PANI–MLG HDG was demonstrated by 92.6% retention after 3000 cycles of galvanostatic charge–discharge. The advantages of this HDG mean that a coin cell supercapacitor assembled using it is a promising energy storage device for mobile and miniaturized electronics.
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Alacid, Yolanda, Andrés F. Quintero Jaime, María José Martínez-Tomé, C. Reyes Mateo, and Francisco Montilla. "Disposable Electrochemical Biosensor Based on the Inhibition of Alkaline Phosphatase Encapsulated in Acrylamide Hydrogels." Biosensors 12, no. 9 (August 29, 2022): 698. http://dx.doi.org/10.3390/bios12090698.

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The present work describes the development of an easy-to-use portable electrochemical biosensor based on alkaline phosphatase (ALP) as a recognition element, which has been immobilized in acrylamide-based hydrogels prepared through a green protocol over disposable screen-printed electrodes. To carry out the electrochemical transduction, an electroinactive substrate (hydroquinone diphosphate) was used in the presence of the enzyme and then it was hydrolyzed to an electroactive species (hydroquinone). The activity of the protein within the matrix was determined voltammetrically. Due to the adhesive properties of the hydrogel, this was easily deposited on the surface of the electrodes, greatly increasing the sensitivity of the biosensor. The device was optimized to allow the determination of phosphate ion, a competitive inhibitor of ALP, in aqueous media. Our study provides a proof-of-concept demonstrating the potential use of the developed biosensor for in situ, real-time measurement of water pollutants that act as ALP inhibitors.
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32

Pfeil, Sascha, Alice Mieting, Rebecca Grün, Konrad Katzer, Johannes Mersch, Cornelia Breitkopf, Martina Zimmermann, and Gerald Gerlach. "Underwater Bending Actuator Based on Integrated Anisotropic Textile Materials and a Conductive Hydrogel Electrode." Actuators 10, no. 10 (October 14, 2021): 270. http://dx.doi.org/10.3390/act10100270.

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Electroactive polymers (EAPs), especially dielectric elastomer actuators (DEAs), belong to a very promising and emerging class of functional materials. While DEAs are mostly utilized to rely on carbon-based electrodes, there are certain shortcomings of the use of carbon electrodes in the field of soft robotics. In this work we present a fish-like bending structure to serve as possible propulsion element, completely avoiding carbon-based electrodes. The presented robot is moving under water, using a particularly tailored conductive hydrogel as inner electrode and a highly anisotropic textile material to manipulate the bending behavior of the robot. The charge separation to drive two DEAs on the outsides of the robot is provided by the conductive hydrogel while the surrounding water serves as counter electrode. To characterize the hydrogel, tensile tests and impedance spectroscopy are used as measurement methods of choice. The performance of the robot was evaluated using a digital image correlation (DIC) measurement for its bending deflections under water. The developed fish-like robot was able to perform a dynamic bending movement, based on a tri-stable actuator setup. The performed measurements underpin the sufficient characteristics for an underwater application of conductive hydrogel electrodes as well as the applicability of the robotic concept for under water actuations.
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Kang, Yong-Woo, Jaesung Woo, Hae-Ryung Lee, and Jeong-Yun Sun. "A mechanically enhanced electroactive hydrogel for 3D printing using a multileg long chain crosslinker." Smart Materials and Structures 28, no. 9 (August 12, 2019): 095016. http://dx.doi.org/10.1088/1361-665x/ab325d.

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34

Manouchehri, Saeed, Babak Bagheri, Somayeh Hosseini Rad, Mojtaba Nasiri Nezhad, Yeu Chun Kim, O. Ok Park, Mehdi Farokhi, et al. "Electroactive bio-epoxy incorporated chitosan-oligoaniline as an advanced hydrogel coating for neural interfaces." Progress in Organic Coatings 131 (June 2019): 389–96. http://dx.doi.org/10.1016/j.porgcoat.2019.03.022.

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35

Homaeigohar, Shahin, Ting-Yu Tsai, Tai-Hong Young, Hsin Ju Yang, and You-Ren Ji. "An electroactive alginate hydrogel nanocomposite reinforced by functionalized graphite nanofilaments for neural tissue engineering." Carbohydrate Polymers 224 (November 2019): 115112. http://dx.doi.org/10.1016/j.carbpol.2019.115112.

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36

Saeaeh, Kochakorn, Natlita Thummarungsan, Nophawan Paradee, Pongpol Choeichom, Katesara Phasuksom, Wanchai Lerdwijitjarud, and Anuvat Sirivat. "Soft and highly responsive multi-walled carbon nanotube/pullulan hydrogel composites as electroactive materials." European Polymer Journal 120 (November 2019): 109231. http://dx.doi.org/10.1016/j.eurpolymj.2019.109231.

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Liu, Yadong, Jun Hu, Xiuli Zhuang, Peibiao Zhang, Yen Wei, Xianhong Wang, and Xuesi Chen. "Synthesis and Characterization of Novel Biodegradable and Electroactive Hydrogel Based on Aniline Oligomer and Gelatin." Macromolecular Bioscience 12, no. 2 (October 25, 2011): 241–50. http://dx.doi.org/10.1002/mabi.201100227.

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Sharma, Anjana, Vineeta Panwar, Bidya Mondal, Dixit Prasher, Milan Kumar Bera, Jijo Thomas, Ajay Kumar, Navpreet Kamboj, Dipankar Mandal, and Deepa Ghosh. "Electrical stimulation induced by a piezo-driven triboelectric nanogenerator and electroactive hydrogel composite, accelerate wound repair." Nano Energy 99 (August 2022): 107419. http://dx.doi.org/10.1016/j.nanoen.2022.107419.

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39

Bejarano-Jiménez, Areli, Vladimir A. Escobar-Barrios, J. Mieke Kleijn, Cesar A. Ortíz-Ledón, and Luis F. Cházaro-Ruiz. "Electroactive behavior assessment of poly(acrylic acid)-graphene oxide composite hydrogel in the detection of cadmium." Journal of Applied Polymer Science 131, no. 19 (May 2, 2014): n/a. http://dx.doi.org/10.1002/app.40846.

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Cui, Haitao, Liguo Cui, Peibiao Zhang, Yubin Huang, Yen Wei, and Xuesi Chen. "In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/Copolymer Inclusion for Tissue Engineering Repair." Macromolecular Bioscience 14, no. 3 (November 8, 2013): 440–50. http://dx.doi.org/10.1002/mabi.201300366.

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Wang, Shen, Lun Yuan, Zhilang Xu, Xianyu Lin, Liming Ge, Defu Li, and Changdao Mu. "Functionalization of an Electroactive Self-Healing Polypyrrole-Grafted Gelatin-Based Hydrogel by Incorporating a Polydopamine@AgNP Nanocomposite." ACS Applied Bio Materials 4, no. 7 (July 7, 2021): 5797–808. http://dx.doi.org/10.1021/acsabm.1c00548.

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He, Liumin, Qiao Xiao, Yuyuan Zhao, Jun Li, Sathish Reddy, Xueshuang Shi, Xin Su, Kin Chiu, and Seeram Ramakrishna. "Engineering an Injectable Electroactive Nanohybrid Hydrogel for Boosting Peripheral Nerve Growth and Myelination in Combination with Electrical Stimulation." ACS Applied Materials & Interfaces 12, no. 47 (November 12, 2020): 53150–63. http://dx.doi.org/10.1021/acsami.0c16885.

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Zhang, Qingzheng, Cong Ning, Changfeng Fu, Jianxun Ding, Xiuli Zhuang, and Xuesi Chen. "Electroactive polyion complex polypeptide hydrogel locally supplies methylprednisolone and microsphere-entrapped neurotrophin-3 for spinal cord injury repair." Journal of Controlled Release 259 (August 2017): e113-e114. http://dx.doi.org/10.1016/j.jconrel.2017.03.236.

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Jing, Xin, Hao-Yang Mi, Brett N. Napiwocki, Xiang-Fang Peng, and Lih-Sheng Turng. "Mussel-inspired electroactive chitosan/graphene oxide composite hydrogel with rapid self-healing and recovery behavior for tissue engineering." Carbon 125 (December 2017): 557–70. http://dx.doi.org/10.1016/j.carbon.2017.09.071.

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45

Karimi Hajishoreh, Negar, Nafiseh Baheiraei, Nasim Naderi, and Mojdeh Salehnia. "Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair." Journal of Bioactive and Compatible Polymers 35, no. 4-5 (July 2020): 363–77. http://dx.doi.org/10.1177/0883911520933913.

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The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical properties. In this study, the reduced graphene oxide incorporation effect within alginate hydrogels was investigated for cardiac repair application. Reduced graphene oxide reinforced alginate properties, resulting in an increase in gel stiffness. The cytocompatibility of the hydrogels prepared with human bone marrow–derived mesenchymal stem cells was assessed by the 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay. Following reduced graphene oxide addition, alginate-reduced graphene oxide retained significantly higher cell viability compared to that of alginate and cells cultured on tissue culture plates. Acridine orange/propidium iodide staining was also used to identify both viable and necrotic human bone marrow–derived mesenchymal stem cells within the prepared hydrogels. After a 72-h culture, the percentage of viable cells was twice as much as those cultured on either alginate or tissue culture plate, reaching approximately 80%. Quantitative reverse transcription polymerase chain reaction analysis was performed to assess gene expression of neonatal rat cardiac cells encapsulated on hydrogels for TrpT-2, Conx43, and Actn4 after 7 days. The expression of all genes in alginate-reduced graphene oxide increased significantly compared to that in alginate or tissue culture plate. The results obtained confirmed that the presence of reduced graphene oxide, as an electro-active moiety within alginate, could tune the physicochemical properties of this material, providing a desirable electroactive hydrogel for stem cell therapy in patients with ischemic heart disease.
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Zhao, Xin, Hao Wu, Baolin Guo, Ruonan Dong, Yusheng Qiu, and Peter X. Ma. "Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing." Biomaterials 122 (April 2017): 34–47. http://dx.doi.org/10.1016/j.biomaterials.2017.01.011.

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Wu, Xuemei, Xiaoqing Bai, Yang Ma, Jie Wei, Juan Peng, Keren Shi, and Huiqin Yao. "Construction of Multiple Switchable Sensors and Logic Gates Based on Carboxylated Multi-Walled Carbon Nanotubes/Poly(N,N-Diethylacrylamide)." Sensors 18, no. 10 (October 8, 2018): 3358. http://dx.doi.org/10.3390/s18103358.

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In this work, binary hydrogel films based on carboxylated multi-walled carbon nanotubes/poly(N,N-diethylacrylamide) (c-MWCNTs/PDEA) were successfully polymerized and assembled on a glassy carbon (GC) electrode surface. The electroactive drug probes matrine and sophoridine in solution showed reversible thermal-, salt-, methanol- and pH-responsive switchable cyclic voltammetric (CV) behaviors at the film electrodes. The control experiments showed that the pH-responsive property of the system could be ascribed to the drug components of the solutions, whereas the thermal-, salt- and methanol-sensitive behaviors were attributed to the PDEA constituent of the films. The CV signals particularly, of matrine and sophoridine were significantly amplified by the electrocatalysis of c-MWCNTs in the films at 1.02 V and 0.91 V, respectively. Moreover, the addition of esterase, urease, ethyl butyrate, and urea to the solution also changed the pH of the system, and produced similar CV peaks as with dilution by HCl or NaOH. Based on these experiments, a 6-input/5-output logic gate system and 2-to-1 encoder were successfully constructed. The present system may lead to the development of novel types of molecular computing systems.
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Tungkavet, Thawatchai, Nispa Seetapan, Datchanee Pattavarakorn, and Anuvat Sirivat. "Graphene/gelatin hydrogel composites with high storage modulus sensitivity for using as electroactive actuator: Effects of surface area and electric field strength." Polymer 70 (July 2015): 242–51. http://dx.doi.org/10.1016/j.polymer.2015.06.027.

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Hurtado, Alejandro, Alba Cano-Vicent, Alberto Tuñón-Molina, Jose Luis Aparicio-Collado, Beatriz Salesa, Roser Sabater i Serra, and Ángel Serrano-Aroca. "Engineering alginate hydrogel films with poly(3-hydroxybutyrate-co-3-valerate) and graphene nanoplatelets: Enhancement of antiviral activity, cell adhesion and electroactive properties." International Journal of Biological Macromolecules 219 (October 2022): 694–708. http://dx.doi.org/10.1016/j.ijbiomac.2022.08.039.

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Nourbakhsh, Melika, Payam Zarrintaj, Seyed Hassan Jafari, Sayed Masoud Hosseini, Shayan Aliakbari, Hamid Gholami Pourbadie, Nima Naderi, et al. "Fabricating an electroactive injectable hydrogel based on pluronic-chitosan/aniline-pentamer containing angiogenic factor for functional repair of the hippocampus ischemia rat model." Materials Science and Engineering: C 117 (December 2020): 111328. http://dx.doi.org/10.1016/j.msec.2020.111328.

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