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Journal articles on the topic 'Elasto-inertial Focusing'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Banerjee, I., M. E. Rosti, T. Kumar, L. Brandt, and A. Russom. "Analogue tuning of particle focusing in elasto-inertial flow." Meccanica 56, no. 7 (March 23, 2021): 1739–49. http://dx.doi.org/10.1007/s11012-021-01329-z.

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AbstractWe report a unique tuneable analogue trend in particle focusing in the laminar and weak viscoelastic regime of elasto-inertial flows. We observe experimentally that particles in circular cross-section microchannels can be tuned to any focusing bandwidths that lie between the “Segre-Silberberg annulus” and the centre of a circular microcapillary. We use direct numerical simulations to investigate this phenomenon and to understand how minute amounts of elasticity affect the focussing of particles at increasing flow rates. An Immersed Boundary Method is used to account for the presence of the particles and a FENE-P model is used to simulate the presence of polymers in a Non-Newtonian fluid. The numerical simulations study the dynamics and stability of finite size particles and are further used to analyse the particle behaviour at Reynolds numbers higher than what is allowed by the experimental setup. In particular, we are able to report the entire migration trajectories of the particles as they reach their final focussing positions and extend our predictions to other geometries such as the square cross section. We believe complex effects originate due to a combination of inertia and elasticity in the weakly viscoelastic regime, where neither inertia nor elasticity are able to mask each other’s effect completely, leading to a number of intermediate focusing positions. The present study provides a fundamental new understanding of particle focusing in weakly elastic and strongly inertial flows, whose findings can be exploited for potentially multiple microfluidics-based biological sorting applications.

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2

Ahn, Sung Won, Sung Sik Lee, Seong Jae Lee, and Ju Min Kim. "Microfluidic particle separator utilizing sheathless elasto-inertial focusing." Chemical Engineering Science 126 (April 2015): 237–43. http://dx.doi.org/10.1016/j.ces.2014.12.019.

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3

Song, Hyeong Yong, Seung Hak Lee, Reza Salehiyan, and Kyu Hyun. "Relationship between particle focusing and dimensionless numbers in elasto-inertial focusing." Rheologica Acta 55, no. 11-12 (September 19, 2016): 889–900. http://dx.doi.org/10.1007/s00397-016-0962-3.

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4

Xiang, Nan, Xinjie Zhang, Qing Dai, Jie Cheng, Ke Chen, and Zhonghua Ni. "Fundamentals of elasto-inertial particle focusing in curved microfluidic channels." Lab on a Chip 16, no. 14 (2016): 2626–35. http://dx.doi.org/10.1039/c6lc00376a.

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5

Zhou, Yinning, Zhichao Ma, and Ye Ai. "Dynamically tunable elasto-inertial particle focusing and sorting in microfluidics." Lab on a Chip 20, no. 3 (2020): 568–81. http://dx.doi.org/10.1039/c9lc01071h.

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We explore the use of non-Newtonian viscoelastic fluids to achieve size-tunable elasto-inertial particle focusing and sorting in a microfluidic device, and realize the controllable tunability among three separation thresholds.

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6

Kim, Min Jung, Jae Ryoun Youn, and Young Seok Song. "Focusing manipulation of microalgae in a microfluidic device using self-produced macromolecules." Lab on a Chip 18, no. 7 (2018): 1017–25. http://dx.doi.org/10.1039/c7lc01324h.

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7

Kim, Min Jung, Doo Jin Lee, Jae Ryoun Youn, and Young Seok Song. "Two step label free particle separation in a microfluidic system using elasto-inertial focusing and magnetophoresis." RSC Advances 6, no. 38 (2016): 32090–97. http://dx.doi.org/10.1039/c6ra03146c.

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8

Xiang, Nan, Qing Dai, and Zhonghua Ni. "Multi-train elasto-inertial particle focusing in straight microfluidic channels." Applied Physics Letters 109, no. 13 (September 26, 2016): 134101. http://dx.doi.org/10.1063/1.4963294.

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9

Xiang, Nan, Zhonghua Ni, and Hong Yi. "Concentration-controlled particle focusing in spiral elasto-inertial microfluidic devices." ELECTROPHORESIS 39, no. 2 (November 14, 2017): 417–24. http://dx.doi.org/10.1002/elps.201700150.

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10

Jang, Jaekyeong, Uihwan Kim, Taehoon Kim, and Younghak Cho. "Elasto-Inertial Particle Focusing in Microchannel with T-Shaped Cross-Section." Applied Sciences 12, no. 20 (October 19, 2022): 10552. http://dx.doi.org/10.3390/app122010552.

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Recently, particle manipulation in non-Newtonian fluids has attracted increasing attention because of a good particle focusing toward the mid-plane of a channel. In this research, we proposed a simple and robust fabrication method to make a microchannel with various T-shaped cross-sections for particle focusing and separation in a viscoelastic solution. SU-8-based soft lithography was used to form three different types of microchannels with T-shaped cross-sections, which enabled self-alignment and plasma bonding between two PDMS molds. The effects of the flow rate and geometric shape of the cross-sections on particle focusing were evaluated in straight microchannels with T-shaped cross-sections. Moreover, by taking images from the top and side part of the channels, it was possible to confirm the position of the particles three-dimensionally. The effects of the corner angle of the channel and the aspect ratio of the height to width of the T shape on the elasto-inertial focusing phenomenon were evaluated and compared with each other using numerical simulation. Simulation results for the particle focusing agreed well with the experimental results both in qualitatively and quantitatively. Furthermore, the numerical study showed a potential implication for particle separation depending on its size when the aspect ratio of the T-shaped microchannel and the flow rate were appropriately leveraged.

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11

Charjouei Moghadam, Mohammad, Armin Eilaghi, and Pouya Rezai. "Elasto-inertial microparticle focusing in straight microchannels: A numerical parametric investigation." Physics of Fluids 33, no. 9 (September 2021): 092002. http://dx.doi.org/10.1063/5.0060709.

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12

Raoufi, Mohammad Amin, Ali Mashhadian, Hamid Niazmand, Mohsen Asadnia, Amir Razmjou, and Majid Ebrahimi Warkiani. "Experimental and numerical study of elasto-inertial focusing in straight channels." Biomicrofluidics 13, no. 3 (May 2019): 034103. http://dx.doi.org/10.1063/1.5093345.

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13

Jiang, Di, Chen Ni, Wenlai Tang, and Nan Xiang. "Numerical simulation of elasto-inertial focusing of particles in straight microchannels." Journal of Physics D: Applied Physics 54, no. 6 (November 18, 2020): 065401. http://dx.doi.org/10.1088/1361-6463/abc19a.

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14

Naderi, Mohammad Moein, Ludovica Barilla, Jian Zhou, Ian Papautsky, and Zhangli Peng. "Elasto-Inertial Focusing Mechanisms of Particles in Shear-Thinning Viscoelastic Fluid in Rectangular Microchannels." Micromachines 13, no. 12 (December 1, 2022): 2131. http://dx.doi.org/10.3390/mi13122131.

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Growth of the microfluidics field has triggered numerous advances in focusing and separating microparticles, with such systems rapidly finding applications in biomedical, chemical, and environmental fields. The use of shear-thinning viscoelastic fluids in microfluidic channels is leading to evolution of elasto-inertial focusing. Herein, we showed that the interplay between the elastic and shear-gradient lift forces, as well as the secondary flow transversal drag force that is caused by the non-zero second normal stress difference, lead to different particle focusing patterns in the elasto-inertial regime. Experiments and 3D simulations were performed to study the effects of flowrate, particle size, and the shear-thinning extent of the fluid on the focusing patterns. The Giesekus constitutive equation was used in the simulations to capture the shear-thinning and viscoelastic behaviors of the solution used in the experiments. At low flowrate, with Weissenberg number Wi ~ O(1), both the elastic force and secondary flow effects push particles towards the channel center. However, at a high flowrate, Wi ~ O(10), the elastic force direction is reversed in the central regions. This remarkable behavior of the elastic force, combined with the enhanced shear-gradient lift at the high flowrate, pushes particles away from the channel center. Additionally, a precise prediction of the focusing position can only be made when the shear-thinning extent of the fluid is correctly estimated in the modeling. The shear-thinning also gives rise to the unique behavior of the inertial forces near the channel walls which is linked with the ‘warped’ velocity profile in such fluids.

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15

Kim, Uihwan, Joo-Yong Kwon, Taehoon Kim, and Younghak Cho. "Particle Focusing in a Straight Microchannel with Non-Rectangular Cross-Section." Micromachines 13, no. 2 (January 20, 2022): 151. http://dx.doi.org/10.3390/mi13020151.

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Recently, studies on particle behavior under Newtonian and non-Newtonian fluids in microchannel have attracted considerable attention because particles and cells of interest can be manipulated and separated from biological samples without any external force. In this paper, two kinds of microchannels with non-rectangular cross-section were fabricated using basic MEMS processes (photolithography, reactive ion etching and anisotropy wet etching), plasma bonding and self-alignment between two PDMS structures. They were used to achieve the experiments for inertial and elasto-inertial particle focusing under Newtonian and non-Newtonian fluids. The particle behavior was compared and investigated for different flow rates and particle size in the microchannel with rhombic and equilateral hexagonal cross section. We also investigated the influence of Newtonian fluid and viscoelastic fluid on particle migration in both microchannels through the numerical simulation. The experimental results showed the multi-line particle focusing in Newtonian fluid over a wide range of flow rates, but the single-line particle focusing was formed in the centerline under non-Newtonian fluid. The tighter particle focusing appeared under non-Newtonian fluid in the microchannel with equilateral hexagonal cross-section than in the microchannel with rhombic cross section because of the effect of an obtuse angle. It revealed that particles suspended in the channel are likely to drift toward a channel center due to a negative net elasto-inertial force throughout the cross-sectional area. Simulation results support the present experimental observation that the viscoelastic fluid in the microchannel with rhombic and equilateral hexagonal cross-section significantly influences on the particle migration toward the channel center owing to coupled effect of inertia and elasticity.

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16

Raffiee, Amir Hossein, Arezoo M. Ardekani, and Sadegh Dabiri. "Numerical investigation of elasto-inertial particle focusing patterns in viscoelastic microfluidic devices." Journal of Non-Newtonian Fluid Mechanics 272 (October 2019): 104166. http://dx.doi.org/10.1016/j.jnnfm.2019.104166.

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17

Xiang, Nan, Zhonghua Ni, and Hong Yi. "Front Cover: Concentration-controlled particle focusing in spiral elasto-inertial microfluidic devices." ELECTROPHORESIS 39, no. 2 (January 2018): NA. http://dx.doi.org/10.1002/elps.201870011.

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18

Yuan, Dan, Say Hwa Tan, Qianbin Zhao, Sheng Yan, Ronald Sluyter, N. T. Nguyen, Jun Zhang, and Weihua Li. "Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid." RSC Advances 7, no. 6 (2017): 3461–69. http://dx.doi.org/10.1039/c6ra25328h.

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Sheathless particle focusing and separation in viscoelastic fluid is demonstrated using an integrated ECCA (straight channel section with asymmetrical expansion–contraction cavity arrays) straight channel.

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19

Yang, Seungyoung, Jae Young Kim, Seong Jae Lee, Sung Sik Lee, and Ju Min Kim. "Sheathless elasto-inertial particle focusing and continuous separation in a straight rectangular microchannel." Lab Chip 11, no. 2 (2011): 266–73. http://dx.doi.org/10.1039/c0lc00102c.

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20

Holzner, Gregor, Stavros Stavrakis, and Andrew deMello. "Elasto-Inertial Focusing of Mammalian Cells and Bacteria Using Low Molecular, Low Viscosity PEO Solutions." Analytical Chemistry 89, no. 21 (October 18, 2017): 11653–63. http://dx.doi.org/10.1021/acs.analchem.7b03093.

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21

Kim, Bookun, and Ju Min Kim. "Elasto-inertial particle focusing under the viscoelastic flow of DNA solution in a square channel." Biomicrofluidics 10, no. 2 (March 2016): 024111. http://dx.doi.org/10.1063/1.4944628.

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22

Kwon, Joo-Yong, Taehoon Kim, Jungwoo Kim, and Younghak Cho. "Particle Focusing under Newtonian and Viscoelastic Flow in a Straight Rhombic Microchannel." Micromachines 11, no. 11 (November 11, 2020): 998. http://dx.doi.org/10.3390/mi11110998.

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Particle behavior in viscoelastic fluids has attracted considerable attention in recent years. In viscoelastic fluids, as opposed to Newtonian fluids, particle focusing can be simply realized in a microchannel without any external forces or complex structures. In this study, a polydimethylsiloxane (PDMS) microchannel with a rhombic cross-sectional shape was fabricated to experimentally investigate the behavior of inertial and elasto-inertial particles. Particle migration and behavior in Newtonian and non-Newtonian fluids were compared with respect to the flow rate and particle size to investigate their effect on the particle focusing position and focusing width. The PDMS rhombic microchannel was fabricated using basic microelectromechanical systems (MEMS) processes. The experimental results showed that single-line particle focusing was formed along the centerline of the microchannel in the non-Newtonian fluid, unlike the double-line particle focusing in the Newtonian fluid over a wide range of flow rates. Numerical simulation using the same flow conditions as in the experiments revealed that the particles suspended in the channel tend to drift toward the center of the channel owing to the negative net force throughout the cross-sectional area. This supports the experimental observation that the viscoelastic fluid in the rhombic microchannel significantly influences particle migration toward the channel center without any external force owing to coupling between the inertia and elasticity.

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23

Yuan, D., J. Zhang, S. Yan, C. Pan, G. Alici, N. T. Nguyen, and W. H. Li. "Dean-flow-coupled elasto-inertial three-dimensional particle focusing under viscoelastic flow in a straight channel with asymmetrical expansion–contraction cavity arrays." Biomicrofluidics 9, no. 4 (July 2015): 044108. http://dx.doi.org/10.1063/1.4927494.

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24

Kumar, Tharagan, Harisha Ramachandraiah, Sharath Narayana Iyengar, Indradumna Banerjee, Gustaf Mårtensson, and Aman Russom. "High throughput viscoelastic particle focusing and separation in spiral microchannels." Scientific Reports 11, no. 1 (April 19, 2021). http://dx.doi.org/10.1038/s41598-021-88047-4.

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AbstractPassive particle manipulation using inertial and elasto-inertial microfluidics have received substantial interest in recent years and have found various applications in high throughput particle sorting and separation. For separation applications, elasto-inertial microfluidics has thus far been applied at substantial lower flow rates as compared to inertial microfluidics. In this work, we explore viscoelastic particle focusing and separation in spiral channels at two orders of magnitude higher Reynolds numbers than previously reported. We show that the balance between dominant inertial lift force, dean drag force and elastic force enables stable 3D particle focusing at dynamically high Reynolds numbers. Using a two-turn spiral, we show that particles, initially pinched towards the inner wall using an elasticity enhancer, PEO (polyethylene oxide), as sheath migrate towards the outer wall strictly based on size and can be effectively separated with high precision. As a proof of principle for high resolution particle separation, 15 µm particles were effectively separated from 10 µm particles. A separation efficiency of 98% for the 10 µm and 97% for the 15 µm particles was achieved. Furthermore, we demonstrate sheath-less, high throughput, separation using a novel integrated two-spiral device and achieved a separation efficiency of 89% for the 10 µm and 99% for the 15 µm particles at a sample flow rate of 1 mL/min—a throughput previously only reported for inertial microfluidics. We anticipate the ability to precisely control particles in 3D at extremely high flow rates will open up several applications, including the development of ultra-high throughput microflow cytometers and high-resolution separation of rare cells for point of care diagnostics.

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25

Tang, Wenlai, Ning Fan, Jiquan Yang, Zongan Li, Liya Zhu, Di Jiang, Jianping Shi, and Nan Xiang. "Elasto-inertial particle focusing in 3D-printed microchannels with unconventional cross sections." Microfluidics and Nanofluidics 23, no. 3 (February 21, 2019). http://dx.doi.org/10.1007/s10404-019-2205-2.

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26

Yuan, Dan, Ronald Sluyter, Qianbin Zhao, Shiyang Tang, Sheng Yan, Guolin Yun, Ming Li, Jun Zhang, and Weihua Li. "Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels." Microfluidics and Nanofluidics 23, no. 3 (February 21, 2019). http://dx.doi.org/10.1007/s10404-019-2204-3.

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27

Bai, Jun-Jie, Xuan Zhang, Xing Wei, Yu Wang, Cheng Du, Ze-Jun Wang, Ming-Li Chen, and Jian-Hua Wang. "Dean-Flow-Coupled Elasto-Inertial Focusing Accelerates Exosome Purification to Facilitate Single Vesicle Profiling." Analytical Chemistry, January 19, 2023. http://dx.doi.org/10.1021/acs.analchem.2c04898.

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28

Shiri, Farhad, Haidong Feng, Kevin E. Petersen, Himanshu Sant, Gina T. Bardi, Luke A. Schroeder, Michael L. Merchant, Bruce K. Gale, and Joshua L. Hood. "Separation of U87 glioblastoma cell-derived small and medium extracellular vesicles using elasto-inertial flow focusing (a spiral channel)." Scientific Reports 12, no. 1 (April 12, 2022). http://dx.doi.org/10.1038/s41598-022-10129-8.

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AbstractNanoscale and microscale cell-derived extracellular vesicle types and subtypes are of significant interest to researchers in biology and medicine. Extracellular vesicles (EVs) have diagnostic and therapeutic potential in terms of biomarker and nanomedicine applications. To enable such applications, EVs must be isolated from biological fluids or separated from other EV types. Developing methods to fractionate EVs is of great importance to EV researchers. Our goal was to begin to develop a device that would separate medium EVs (mEVs, traditionally termed microvesicles or shedding vesicles) and small EVs (sEVs, traditionally termed exosomes) by elasto-inertial effect. We sought to develop a miniaturized technology that works similar to and provides the benefits of differential ultracentrifugation but is more suitable for EV-based microfluidic applications. The aim of this study was to determine whether we could use elasto-inertial focusing to re-isolate and recover U87 mEVs and sEVs from a mixture of mEVs and sEVs isolated initially by one round of differential ultracentrifugation. The studied spiral channel device can continuously process 5 ml of sample fluid per hour. Using the channel, sEVs and mEVs were recovered and re-isolated from a mixture of U87 glioma cell-derived mEVs and sEVs pre-isolated by one round of differential ultracentrifugation. Following two passes through the spiral channel, approximately 55% of sEVs were recovered with 6% contamination by mEVs (the recovered sEVs contained 6% of the total mEVs). In contrast, recovery of U87 mEVs and sEVs re-isolated using a typical second centrifugation wash step was only 8% and 53%, respectively. The spiral channel also performed similar to differential ultracentrifugation in reisolating sEVs while significantly improving mEV reisolation from a mixture of U87 sEVs and mEVs. Ultimately this technology can also be coupled to other microfluidic EV isolation methods in series and/or parallel to improve isolation and minimize loss of EV subtypes.

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