Journal articles on the topic 'EIMD'
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1
Rahaman, Md Mohibur, Mohammad Khairul Islam, Kazi Ashrafuzzaman, and Mohammad Sanaullah Chowdhury. "Performance Evaluation of Different Backoff Algorithms in IEEE 802.15.4 using Double Sensing." Indonesian Journal of Electrical Engineering and Computer Science 5, no. 2 (February 1, 2017): 376. http://dx.doi.org/10.11591/ijeecs.v5.i2.pp376-382.
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<p>The IEEE 802.15.4 is the standard for Low Rate Wireless Personal Area network (LR-WPAN). It is widely used in many application areas. The standard uses Slotted CSMA/CA mechanism in its contention access period (CAP) for the beacon enabled mode. The protocol has two modes - single sensing (SS) and double sensing (DS). The protocol also adopts a binary exponential backoff (BEB) algorithm. In this paper, we explore the saturation throughput, delay and energy consumption of this standard with double sensing (DS) using the existing BEB algorithm. We also investigate three other backoff schemes - exponential increase exponential decrease (EIED), exponential increase linear decrease (EILD) and exponential increase multiplicative decrease (EIMD). From simulation results, it is found that the EIED, EILD, EIMD perform better than the BEB for higher loads. It shows that the EIED, EILD, EIMD have better throughput and lower delay than the BEB. The EIED outperforms the other schemes in terms of throughput, delay and energy for the higher loads.</p>
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Presti, Nicole, Enoch Huang, J. Luke Pryor, and David Hostler. "Effects of hyperbaric oxygen therapy on exercise-induced muscle damage." Undersea and Hyperbaric Medicine 49, no. 3 (May 6, 2022): 315–27. http://dx.doi.org/10.22462/05.06.2022.5.
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Purpose: To perform a literature review on hyperbaric oxygen (HBO2) therapy as a treatment forexercise-induced muscle damage (EIMD). Methods: PubMed, Web of Science and Google Scholar were searched for articles related to HBO2 therapy as a treatment for exercise-induced muscle damage. Inclusion criteria included HBO2 therapy as the primary intervention to treat EIMD. Articles used in this review ranged from 1995-2021. Conclusion: Current literature on the effectiveness of HBO2 therapy to treat EIMD is mixed. Early and frequent treatments seem to be important factors when it comes to the success of HBO2 therapy. Additional research is needed to determine if HBO2 therapy has potential to treat more severe forms of EIMD and the role HBO2 therapy has on inflammation and satellite cell function after EIMD.
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Davies, Rosemary C., Roger G. Eston, Jonathan Fulford, Ann V. Rowlands, and Andrew M. Jones. "Muscle damage alters the metabolic response to dynamic exercise in humans: a31P-MRS study." Journal of Applied Physiology 111, no. 3 (September 2011): 782–90. http://dx.doi.org/10.1152/japplphysiol.01021.2010.
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We used31P-magnetic resonance spectroscopy to test the hypothesis that exercise-induced muscle damage (EIMD) alters the muscle metabolic response to dynamic exercise, and that this contributes to the observed reduction in exercise tolerance following EIMD in humans. Ten healthy, physically active men performed incremental knee extensor exercise inside the bore of a whole body 1.5-T superconducting magnet before (pre) and 48 h after (post) performing 100 squats with a load corresponding to 70% of body mass. There were significant changes in all markers of muscle damage [perceived muscle soreness, creatine kinase activity (434% increase at 24 h), and isokinetic peak torque (16% decrease at 24 h)] following eccentric exercise. Muscle phosphocreatine concentration ([PCr]) and pH values during incremental exercise were not different pre- and post-EIMD ( P > 0.05). However, resting inorganic phosphate concentration ([Pi]; pre: 4.7 ± 0.8; post: 6.7 ± 1.7 mM; P < 0.01) and, consequently, [Pi]/[PCr] values (pre: 0.12 ± 0.02; post: 0.18 ± 0.05; P < 0.01) were significantly elevated following EIMD. These mean differences were maintained during incremental exercise ( P < 0.05). Time to exhaustion was significantly reduced following EIMD (519 ± 56 and 459 ± 63 s, pre- and post-EIMD, respectively, P < 0.001). End-exercise pH (pre: 6.75 ± 0.04; post: 6.83 ± 0.04; P < 0.05) and [PCr] (pre: 7.2 ± 1.7; post: 14.5 ± 2.1 mM; P < 0.01) were higher, but end-exercise [Pi] was not significantly different (pre: 19.7 ± 1.9; post: 21.1 ± 2.6 mM, P > 0.05) following EIMD. The results indicate that alterations in phosphate metabolism, specifically the elevated [Pi] at rest and throughout exercise, may contribute to the reduced exercise tolerance observed following EIMD.
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Clifford, Tom. "Nutritional and Pharmacological Interventions to Expedite Recovery Following Muscle-Damaging Exercise in Older Adults: A Narrative Review of the Literature." Journal of Aging and Physical Activity 27, no. 6 (December 1, 2019): 914–28. http://dx.doi.org/10.1123/japa.2018-0351.
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Exercise-induced muscle damage (EIMD) manifests as muscle soreness, inflammation, and reductions in force generating capacity that can last for several days after exercise. The ability to recover and repair damaged tissues following EIMD is impaired with age, with older adults (≥50 years old) experiencing a slower rate of recovery than their younger counterparts do for the equivalent exercise bout. This narrative review discusses the literature examining the effect of nutritional or pharmacological supplements taken to counter the potentially debilitating effects of EIMD in older adults. Studies have assessed the effects of nonsteroidal anti-inflammatory drugs, vitamin C and/or E, or higher protein diets on recovery in older adults. Each intervention showed some promise for attenuating EIMD, but, overall, there is a paucity of available data in this population, and more studies are required to determine the influence of nutrition or pharmacological interventions on EIMD in older adults.
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Kondrashova, E. A., N. I. Belostotsky, A. G. Strachuk, E. V. Baulo, and A. I. Parfenov. "Successful Diagnosтic and Treatment of Enteropathy with Impaired Membrane Digestion by FODMAP-diet and Rebamipid." Effective Pharmacotherapy 18, no. 14 (April 30, 2022): 66–69. http://dx.doi.org/10.33978/2307-3586-2022-18-14-66-69.
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A decrease in the activity of disaccharidases in the duodenal mucosa made it possible to establish in patient K. enteropathy with impaired membrane digestion (EIMD). An increase in the activity of disaccharidases in the distal ileum during EIMD is a verification of the formation of a compensatory reaction according to the type of proximodistal gradients. Treatment with the cytoprotector rebamipide for 12 weeks increases the enzymatic activity of the small intestine in EIMD.
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Chen, Hou-Yu, Yung-Chih Chen, Kang Tung, Hsiao-Han Chao, and Ho-Seng Wang. "Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial." Journal of Applied Physiology 127, no. 3 (September 1, 2019): 798–805. http://dx.doi.org/10.1152/japplphysiol.01108.2018.
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The present study aims to investigate effects of caffeine ingestion and sex difference on muscle performance, delayed-onset muscle soreness (DOMS), and various biomarkers under exercise-induced muscle damage (EIMD). Twenty (10 male and 10 female) healthy elite college athletes were recruited. Participants ingested either caffeine (6 mg/kg) or a placebo in a randomized, double-blind, and counterbalanced fashion at 24 and 48 h following EIMD. Muscle performance, DOMS, and blood samples were taken an hour before and an hour after supplementation. Caffeine ingestion restored impaired maximal voluntary isometric contractions (MVIC: 10.2%; MVICpost: 7.2%, both P < 0.05) during EIMD across both sexes. Following caffeine ingestion during MVIC, while affected by EIMD, an interaction was found in DOMS and serum K+ (both P < 0.05), with males showing greater attenuation (21.5 and 16.9%, respectively) compared with females (4.6 and 1.3%, respectively). DOMS demonstrated an inverse correlation with MVIC after caffeine ingestion both overall and among male athletes ( r = −0.34 and −0.54, respectively; P < 0.05) but not among female athletes ( r = −0.11; P > 0.05) under EIMD. In addition, caffeine ingestion increased postexercise serum glucose and lactate concentrations across both sexes (both P < 0.05). This is the first study to show that male athletes, compared with female athletes, experience a greater reduction in DOMS during enhanced MVIC when caffeine was consumed, suggesting men might receive greater ergogenic effects from caffeine when affected by EIMD. Furthermore, caffeine ingestion was able to restore impaired muscle power among elite collegiate athletes across both sexes. NEW & NOTEWORTHY Exercise-induced muscle damage (EIMD) reduces anaerobic/aerobic performance and increases delayed-onset muscle soreness (DOMS) during exercise. We show that acute caffeine supplementation at a dosage of 6 mg/kg seems to facilitate recovery of anaerobic muscle power and attenuate DOMS after EIMD across both sexes. Furthermore, male athletes, compared with female athletes, when caffeine was prescribed, experience a greater reduction in DOMS with better restoration of impaired maximal voluntary isometric contractions. This suggests that male athletes might benefit from the ergogenic effect of acute caffeine supplementation after the onset of EIMD.
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Lapointe, Benoît M., Jérôme Frenette, and Claude H. Côté. "Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion." Journal of Applied Physiology 92, no. 5 (May 1, 2002): 1995–2004. http://dx.doi.org/10.1152/japplphysiol.00803.2001.
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Inflammation triggered by exercise-induced muscle damage (EIMD) has been postulated to influence the extent of tissue destruction. We tested the hypotheses that 1) repressing inflammation decreases secondary damage production and 2) EIMD leads to a sequential appearance of inflammatory cells in which neutrophil accumulation precedes macrophage invasion. Rat ankle dorsiflexor muscles were submitted to in situ lengthening contractions. Measurement of in vitro contractile properties, inflammatory cell concentrations, and histological staining were performed postprotocol. Rats were treated with diclofenac, a nonsteroidal anti-inflammatory drug (NSAID group) to repress inflammation or with the vehicle solution (EIMD group). Muscles from the NSAID group had smaller force deficits on days 2 and 3 postexercise. This effect was associated with significantly smaller increases in the concentration of muscle macrophage ED1+ and ED2+. Surprisingly, neutrophils did not accumulate post-EIMD. These results suggest that inflammation-induced ED1+ macrophage accumulation is responsible for the secondary damage observed 2–3 days post-EIMD. We further conclude that an increase in ED1+ macrophage concentration can occur in absence of previous neutrophil invasion.
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Chalchat, Emeric, Anne-Fleur Gaston, Keyne Charlot, Luis Peñailillo, Omar Valdés, Pierre-Emmanuel Tardo-Dino, Kazunori Nosaka, Vincent Martin, Sebastian Garcia-Vicencio, and Julien Siracusa. "Appropriateness of indirect markers of muscle damage following lower limbs eccentric-biased exercises: A systematic review with meta-analysis." PLOS ONE 17, no. 7 (July 14, 2022): e0271233. http://dx.doi.org/10.1371/journal.pone.0271233.
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Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the 141 studies included. Association between MVCloss24-48h levels and participant´s characteristics or exercise type/modalities were assessed. Meta-regressions were performed to investigate the associations between MVCloss24-48h and EIMD markers changes at <6h, 24h, 48h, 72h and >96h after exercise. Results Time-course of EIMD markers recovery differs between levels of MVCloss24-48h. Training status and exercise type/modality were associated with MVCloss24-48h level (p<0.05). MVCloss24-48h was correlated to changes in myoglobin concentration (<6h), jump height (24h) and range of motion (48h) (p<0.001). Conclusion As the exercise could differently affect markers as function of the EIMD severity (i.e., MVCloss24-48h levels), different markers should be used as function of the timing of measurement. Mb concentration should be used during the first hours after the exercise (<6h), whereas jump height (24h) and range of motion (48h) could be used as surrogate for maximal voluntary contraction later. Moreover, training status and exercise type/modality could influence the magnitude of MVCloss24-48h.
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Cockburn, Emma, Philip R. Hayes, Duncan N. French, Emma Stevenson, and Alan St Clair Gibson. "Acute milk-based protein–CHO supplementation attenuates exercise-induced muscle damage." Applied Physiology, Nutrition, and Metabolism 33, no. 4 (August 2008): 775–83. http://dx.doi.org/10.1139/h08-057.
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Exercise-induced muscle damage (EIMD) leads to the degradation of protein structures within the muscle. This may subsequently lead to decrements in muscle performance and increases in intramuscular enzymes and delayed-onset muscle soreness (DOMS). Milk, which provides protein and carbohydrate (CHO), may lead to the attenuation of protein degradation and (or) an increase in protein synthesis that would limit the consequential effects of EIMD. This study examined the effects of acute milk and milk-based protein–CHO (CHO-P) supplementation on attenuating EIMD. Four independent groups of 6 healthy males consumed water (CON), CHO sports drink, milk-based CHO-P or milk (M), post EIMD. DOMS, isokinetic muscle performance, creatine kinase (CK), and myoglobin (Mb) were assessed immediately before and 24 and 48 h after EIMD. DOMS was not significantly different (p > 0.05) between groups at any time point. Peak torque (dominant) was significantly higher (p < 0.05) 48 h after CHO-P compared with CHO and CON, and M compared with CHO. Total work of the set (dominant) was significantly higher (p < 0.05) 48 h after CHO-P and M compared with CHO and CON. CK was significantly lower (p < 0.05) 48 h after CHO-P and M compared with CHO. Mb was significantly lower (p < 0.05) 48 h after CHO-P compared with CHO. At 48 h post-EIMD, milk and milk-based protein–CHO supplementation resulted in the attenuation of decreases in isokinetic muscle performance and increases in CK and Mb.
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Dabbs, Nicole, and Harish Chander. "The Effects of Exercise Induced Muscle Damage on Knee Joint Torque and Balance Performance." Sports 6, no. 3 (September 19, 2018): 101. http://dx.doi.org/10.3390/sports6030101.
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The purpose of this investigation is to determine the effects of exercise induced muscle damage (EIMD) on balance and knee joint torque. Thirteen males and females volunteered to participate in the study. Following a familiarization session, baseline measures were obtained for isometric torque measured during a maximal voluntary isometric contraction (MVIC) for knee flexors and extensors, and ankle dorsi-flexors and plantar-flexors. Additionally, balance performance was tested in double leg (DL), and right single leg (RSL) static and dynamic unstable stability was measured. Participants then performed the muscle damage protocol of front loaded Bulgarian split squats. All measurements were re-assessed for torque and balance immediately and up to 72 h afterwards. A one-way repeated-measures analysis of variance (ANOVA) was used to analyze differences between baseline and all time-points for torque and balance measures. There was a significant time effect for knee extensors MVIC torque, where baseline measures are greater than post EIMD, 24 h and 48 h post EIMD. There was no significant time effect for all balance conditions. These results provide evidence of EIMD following high intensity eccentric exercises with significant reductions in knee extensor torque up to at least 48 h and show that balance was not compromised following EIMD.
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Parfenov, A. I., O. V. Akhmadullina, N. I. Belostotsky, E. A. Sabelnikova, A. A. Novikov, S. V. Bykova, and S. R. Dbar. "Enteropathy with impaired membrane digestion and the prospects for cytoprotective therapy." Terapevticheskii arkhiv 93, no. 2 (February 15, 2021): 129–37. http://dx.doi.org/10.26442/00403660.2021.02.200602.
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The article describes enteropathy with impaired membrane digestion (EIMD) as a new nosological form. The main clinical manifestation of EIMD is the poor tolerance of food products, in particular carbohydrates and a decrease in the activity of membrane enzymes, in particular, carbohydrates, in the mucous membrane of the small intestine. The cause of the disease can be acute intestinal infections, viruses, drugs and other agents that damage the small intestine. The pathophysiology, clinical picture and diagnosis of EIMD are described. The basis of therapy is rebamipide, which has the ability to reduce the symptoms of carbohydrate intolerance and increase the activity of disaccharidases.
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Percival, Stuart, Dave T. Sims, and Georgina K. Stebbings. "Local Vibration Therapy, Oxygen Resaturation Rate, and Muscle Strength After Exercise-Induced Muscle Damage." Journal of Athletic Training 57, no. 5 (August 17, 2021): 502–9. http://dx.doi.org/10.4085/1062-6050-0064.21.
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Context Exercise-induced muscle damage (EIMD) is associated with transient reductions in strength and athletic performance. Muscle microvascular damage and disruption of blood flow are believed to be among the causes. Previous researchers reported modulations in muscle blood flow, oxygenation, and strength with vibration therapy (VT). Objective To observe whether local VT alleviated the impairments and hemodynamic changes associated with EIMD. Design Controlled laboratory study. Setting Laboratory and public gymnasium. Patients or Other Participants A total of 10 healthy participants (6 men and 4 women; age = 38 ± 15 years; height = 1.72 ± 0.48 m; mass = 72.0 ± 10.4 kg) were randomized into experimental (VT) and control groups. Interventions Both groups performed 10 sets of 10 eccentric wrist flexions at 70% of their 1-repetition maximum to induce muscle damage. Subsequent assessment of flexor carpus ulnaris muscle oxygen saturation and wrist-flexor strength occurred at 1, 24, and 48 hours postexercise. The experimental group underwent 10 minutes of local VT (45 Hz) starting 1 hour postexercise and applied twice daily (separated by 8 hours) for 48 hours during habitual waking hours. The control group received no local VT. Main Outcome Measure(s) Resting muscle oxygen saturation (SmO2), grip strength, and muscle oxygen desaturation and resaturation rates. Results No difference in SmO2 resaturation was evident over time (P > .05), but the VT group had a greater resaturation rate than the control group at 1 hour (P = .007, d = 2.6), 24 hours (P = .001, d = 3.1), and 48 hours (P = .035, d = 1.7) post-EIMD. No difference in grip strength was observed pre-EIMD, but the VT group demonstrated greater strength at 1 hour (P = .004), 24 hours (P = .031), and 48 hours (P = .021) post-EIMD than did the control group. Conclusions Local VT successfully attenuated the effects of EIMD and increased SmO2 resaturation in flexor carpus ulnaris muscles. Including local VT as part of a recovery protocol post-EIMD could be beneficial for rehabilitation and strength training purposes.
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Junglee, Naushad A., Umberto Di Felice, Alberto Dolci, Matthew B. Fortes, Mahdi M. Jibani, Andrew B. Lemmey, Neil P. Walsh, and Jamie H. Macdonald. "Exercising in a hot environment with muscle damage: effects on acute kidney injury biomarkers and kidney function." American Journal of Physiology-Renal Physiology 305, no. 6 (September 15, 2013): F813—F820. http://dx.doi.org/10.1152/ajprenal.00091.2013.
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Unaccustomed strenuous physical exertion in hot environments can result in heat stroke and acute kidney injury (AKI). Both exercise-induced muscle damage and AKI are associated with the release of interleukin-6, but whether muscle damage causes AKI in the heat is unknown. We hypothesized that muscle-damaging exercise, before exercise in the heat, would increase kidney stress. Ten healthy euhydrated men underwent a randomized, crossover trial involving both a 60-min downhill muscle-damaging run (exercise-induced muscle damage; EIMD), and an exercise intensity-matched non-muscle-damaging flat run (CON), in random order separated by 2 wk. Both treatments were followed by heat stress elicited by a 40-min run at 33°C. Urine and blood were sampled at baseline, after treatment, and after subjects ran in the heat. By design, EIMD induced higher plasma creatine kinase and interleukin-6 than CON. EIMD elevated kidney injury biomarkers (e.g., urinary neutrophil gelatinase-associated lipocalin (NGAL) after a run in the heat: EIMD-CON, mean difference [95% CI]: 12 [5, 19] ng/ml) and reduced kidney function (e.g., plasma creatinine after a run in the heat: EIMD-CON, mean difference [95% CI]: 0.2 [0.1, 0.3] mg/dl), where CI is the confidence interval. Plasma interleukin-6 was positively correlated with plasma NGAL ( r = 0.9, P = 0.001). Moreover, following EIMD, 5 of 10 participants met AKIN criteria for AKI. Thus for the first time we demonstrate that muscle-damaging exercise before running in the heat results in a greater inflammatory state and kidney stress compared with non-muscle-damaging exercise. Muscle damage should therefore be considered a risk factor for AKI when performing exercise in hot environments.
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Brown, Meghan A., Emma J. Stevenson, and Glyn Howatson. "Whey protein hydrolysate supplementation accelerates recovery from exercise-induced muscle damage in females." Applied Physiology, Nutrition, and Metabolism 43, no. 4 (April 2018): 324–30. http://dx.doi.org/10.1139/apnm-2017-0412.
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A number of different forms of protein and their analogues have been investigated for their efficacy in ameliorating exercise-induced muscle damage (EIMD) and recovery. Preliminary data regarding whey protein hydrolysate (WPH) supplementation are promising. However, its efficacy beyond acute eccentric/resistance exercise bouts or longer term training programmes are limited and all investigations have been conducted in male or mixed-sex groups. This study sought to elucidate whether the benefits of WPH previously reported can be demonstrated in females following repeated-sprint exercise. Twenty physically active females were assigned to consume 2 doses of 70 mL WPH or isoenergetic carbohydrate (CHO) for 4 days post-EIMD. Measures of muscle soreness, limb girth, flexibility, muscle function, and creatine kinase were collected before, immediately after, and 24, 48, and 72 h postexercise. Time effects were observed for all variables (p < 0.05) except limb girth, which is indicative of EIMD. Flexibility improved beyond baseline measures following WPH by 72 h, but had failed to recover in the CHO group (p = 0.011). Reactive strength index was higher throughout recovery in the WPH group compared with CHO (p = 0.016). Reductions in creatine kinase were greater following WPH compared with CHO at 48 h post-EIMD (p = 0.031). The findings suggest that 4-day supplementation of WPH is beneficial for reducing symptoms of EIMD and improving recovery of muscle function in physically active females.
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Bontemps, Bastien, Fabrice Vercruyssen, Mathieu Gruet, and Julien Louis. "Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review." Sports Medicine 50, no. 12 (October 9, 2020): 2083–110. http://dx.doi.org/10.1007/s40279-020-01355-z.
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AbstractDownhill running (DR) is a whole-body exercise model that is used to investigate the physiological consequences of eccentric muscle actions and/or exercise-induced muscle damage (EIMD). In a sporting context, DR sections can be part of running disciplines (off-road and road running) and can accentuate EIMD, leading to a reduction in performance. The purpose of this narrative review is to: (1) better inform on the acute and delayed physiological effects of DR; (2) identify and discuss, using a comprehensive approach, the DR characteristics that affect the physiological responses to DR and their potential interactions; (3) provide the current state of evidence on preventive and in-situ strategies to better adapt to DR. Key findings of this review show that DR may have an impact on exercise performance by altering muscle structure and function due to EIMD. In the majority of studies, EIMD are assessed through isometric maximal voluntary contraction, blood creatine kinase and delayed onset muscle soreness, with DR characteristics (slope, exercise duration, and running speed) acting as the main influencing factors. In previous studies, the median (25th percentile, Q1; 75th percentile, Q3) slope, exercise duration, and running speed were − 12% (− 15%; − 10%), 40 min (30 min; 45 min) and 11.3 km h−1 (9.8 km h−1; 12.9 km h−1), respectively. Regardless of DR characteristics, people the least accustomed to DR generally experienced the most EIMD. There is growing evidence to suggest that preventive strategies that consist of prior exposure to DR are the most effective to better tolerate DR. The effectiveness of in-situ strategies such as lower limb compression garments and specific footwear remains to be confirmed. Our review finally highlights important discrepancies between studies in the assessment of EIMD, DR protocols and populations, which prevent drawing firm conclusions on factors that most influence the response to DR, and adaptive strategies to DR.
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Naughton, Mitchell, Joanna Miller, and Gary J. Slater. "Impact-Induced Muscle Damage and Contact Sports: Etiology, Effects on Neuromuscular Function and Recovery, and the Modulating Effects of Adaptation and Recovery Strategies." International Journal of Sports Physiology and Performance 13, no. 8 (September 1, 2018): 962–69. http://dx.doi.org/10.1123/ijspp.2017-0268.
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Athletes involved in contact sports are habitually exposed to skeletal-muscle damage in their training and performance environments. This often leads to exercise-induced muscle damage (EIMD) resulting from repeated eccentric and/or high-intensity exercise and to impact-induced muscle damage (IIMD) resulting from collisions with opponents and the playing surface. While EIMD has been an area of extensive investigation, IIMD has received comparatively little research, with the magnitude and time frame of alterations following IIMD not presently well understood. It is currently thought that EIMD results from an overload of mechanical stress that causes ultrastructural damage to the cellular membrane constituents. Damage leads to compromised ability to produce force, which manifests immediately and persists for up to 14 d following exercise exposure. IIMD has been implicated in attenuated neuromuscular performance and recovery and in inflammatory processes, although the underlying course over time remains unclear. Exposure to EIMD leads to an adaptation to subsequent exposures, a phenomenon known as the repeated-bout effect. An analogous adaptation has been suggested to occur following IIMD; however, to date, this contention remains equivocal. While a considerable body of research has explored the efficacy of recovery strategies following EIMD, strategies promoting recovery from IIMD are limited to investigations using animal contusion models. Strategies such as cryotherapy and antioxidant supplementation that focus on attenuating the secondary inflammatory response may provide additional benefit in IIMD and are explored herein. Further research is required to first establish a model of generating IIMD and then explore broader areas around IIMD in athletic populations.
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Viribay, Aitor, Soledad Arribalzaga, Juan Mielgo-Ayuso, Arkaitz Castañeda-Babarro, Jesús Seco-Calvo, and Aritz Urdampilleta. "Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners." Nutrients 12, no. 5 (May 11, 2020): 1367. http://dx.doi.org/10.3390/nu12051367.
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Background—exercise-induced muscle damage (EIMD) and internal exercise load are increased after competing in ultraendurance events such as mountain marathons. Adequate carbohydrate (CHO) intake during exercise optimizes athletic performance and could limit EIMD, reduce internal exercise load and, thus, improve recovery. Therefore, the aim of this study was to research into and compare the effects of high CHO intake (120 g/h) in terms of CHO intake recommendation (90 g/h) and regular CHO intake performed by ultraendurance athletes (60 g/h) during a mountain marathon, on exercise load and EIMD markers (creatine kinase (CK), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), urea and creatinine). Materials and Methods—a randomized trial was carried out on 20 male elite runners who had previously undertaken nutritional and gut training, and who consumed different CHO dosages according to experimental (EXP—120 g/h), control (CON—90 g/h) and low CHO intake (LOW—60 g/h) groups during a ~4000 m cumulative slope mountain marathon. EIMD markers were analyzed before the race and 24 h afterwards. Internal exercise load was calculated based on rate of perceived exertion (RPE) during and after the marathon event. Results—internal exercise load during the mountain marathon was significantly lower (p = 0.019; η2p = 0.471) in EXP (3805 ± 281 AU) compared to LOW (4688 ± 705 AU) and CON (4692 ± 716 AU). Moreover, results revealed that the EXP group evidenced significantly lower CK (p = 0.019; η2p = 0.373), LDH (p < 0.001; η2p = 0.615) and GOT (p = 0.003; η2p = 0.500) values 24 h after the mountain marathon race compared to LOW and CON. Along these lines, EIMD and exercise load evidenced a close correlation (R = 0.742; p < 0.001). Conclusion: High CHO intake (120 g/h) during a mountain marathon could limit the EIMD observed by CK, LDH and GOT and internal exercise load compared to CHO ingestion of 60 and 90 g/h.
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Xu, Fei, Jinshu Zeng, Xuan Liu, Jiaming Lai, and Jing Xu. "Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis." Nutrients 14, no. 20 (October 14, 2022): 4288. http://dx.doi.org/10.3390/nu14204288.
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Numerous studies have covered exercise-induced muscle damage (EIMD) topics, ranging from nutritional strategies to recovery methods, but few attempts have adequately explored and analyzed large volumes of scientific output. The purpose of this study was to assess the scientific output and research activity regarding EIMD and protein intake by conducting a bibliometric and visual analysis. Relevant publications from 1975–2022 were retrieved from the Web of Science Core Collection database. Quantitative and qualitative variables were collected, including the number of publications and citations, H-indexes, journals of citation reports, co-authorship, co-citation, and the co-occurrence of keywords. There were 351 total publications, with the number of annual publications steadily increasing. The United States has the highest total number of publications (26.21% of total publications, centrality 0.44). Institutional cooperation is mostly geographically limited, with few transnational cooperation links. EIMD and protein intake research is concentrated in high-quality journals in the disciplines of Sport Science, Physiology, Nutrition, and Biochemistry & Molecular Biology. The top ten journals in the number of publications are mostly high-quality printed journals, and the top ten journals in centrality have an average impact factor of 13.845. The findings of the co-citation clusters and major keyword co-occurrence reveal that the most discussed research topics are “exercise mode”, “nutritional strategies”, “beneficial outcomes”, and “proposed mechanisms”. Finally, we identified the following research frontiers and research directions: developing a comprehensive understanding of new exercise or training models, nutritional strategies, and recovery techniques to alleviate EIMD symptoms and accelerate recovery; applying the concept of hormesis in EIMD to induce muscle hypertrophy; and investigating the underlying mechanisms of muscle fiber and membrane damage.
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Mielgo-Ayuso, Juan, Julio Calleja-González, Ignacio Refoyo, Patxi León-Guereño, Alfredo Cordova, and Juan Del Coso. "Exercise-Induced Muscle Damage and Cardiac Stress During a Marathon Could be Associated with Dietary Intake During the Week Before the Race." Nutrients 12, no. 2 (January 25, 2020): 316. http://dx.doi.org/10.3390/nu12020316.
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Adequate food intake is important prior to endurance running competitions to facilitate adequate exercise intensity. However, no investigations have examined whether dietary intake could prevent exercise-induced muscle damage (EIMD) and cardiac stress (EICS). Thus, this study’s objective was to determine the associations between EIMD, EICS and endurance athlete diets one week before a marathon race. Sixty-nine male runners participated in this study. Food intake during the week prior to the race was collected through a seven-day weighed food record. Dietary intake on race day was also recorded. At the end of the marathon, blood samples were drawn to determine serum creatine kinase (CK) and myoglobin, and muscle–brain isoform creatine kinase (CK-MB), prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (TNI), and cardiac troponin T (TNT) concentration as markers of EIMD and EICS, respectively. To determine the association between these variables, a stepwise regression analysis was carried out. The dependent variable was defined as EIMD or EICS and the independent variables were defined as the number of servings within each different food group. Results showed that the intake of meat during the previous week was positively associated with post-race CK (Standardized Coefficients (β) = 0.643; p < 0.01) and myoglobin (β = 0.698; p < 0.001). Vegetables were negatively associated the concentration of post-race CK (β = −0.482; p = 0.002). Butter and fatty meat were positively associated with NT-proBNP (β = 0.796; p < 0.001) and TNI (β = 0.396; p < 0.001) post-marathon values. However, fish intake was negatively associated with CK (β = −0.272; p = 0.042), TNI (β = −0.593; p < 0.001) and TNT (β = −0.640; p = 0.002) post-marathon concentration. Olive oil was negatively associated with TNI (β = −0.536; p < 0.001) and TNT (β = −0.415; p = 0.021) values. In conclusion, the consumption of meat, butter, and fatty meat might be associated with higher levels of EIMD and EICS. On the other hand, fish, vegetables, and olive oil might have a protective role against EIMD and EICS. The selection of an adequate diet before a marathon might help to reduce some of the acute burdens associated with marathon races.
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Stedge, Hannah L., and Kirk Armstrong. "The Effects of Intermittent Pneumatic Compression on the Reduction of Exercise-Induced Muscle Damage in Endurance Athletes: A Critically Appraised Topic." Journal of Sport Rehabilitation 30, no. 4 (May 1, 2021): 668–71. http://dx.doi.org/10.1123/jsr.2020-0364.
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Clinical Scenario: Endurance sports require a great deal of physical training to perform well. Endurance training and racing stress the skeletal muscle, resulting in exercise-induced muscle damage (EIMD). Athletes attempt to aid their recovery in various ways, one of which is through compression. Dynamic compression consists of intermittent pneumatic compression (IPC) devices, such as the NormaTec Recovery System and Recovery Pump. Clinical Question: What are the effects of IPC on the reduction of EIMD in endurance athletes following prolonged exercise? Summary of Key Findings: The current literature was searched to identify the effects of IPC, and 3 studies were selected: 2 randomized controlled trials and 1 randomized cross-over study. Two studies investigated the effect of IPC on delayed onset muscle soreness and plasma creatine kinase in ultramarathoners. The other looked at the impact of IPC on delayed onset muscle soreness in marathoners, ultramarathoners, triathletes, and cyclists. All studies concluded IPC was not an effective means of improving the reduction of EIMD in endurance-trained athletes. Clinical Bottom Line: While IPC may provide short-term relief of delayed onset muscle soreness, this device does not provide continued relief from EIMD. Strength of Recommendation: In accordance with the Strength of Recommendation Taxonomy, the grade of B is recommended based on consistent evidence from 2 high-quality randomized controlled trials and 1 randomized cross-over study.
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Cockburn, Emma, Emma Stevenson, Philip R. Hayes, Paula Robson-Ansley, and Glyn Howatson. "Effect of milk-based carbohydrate-protein supplement timing on the attenuation of exercise-induced muscle damage." Applied Physiology, Nutrition, and Metabolism 35, no. 3 (June 2010): 270–77. http://dx.doi.org/10.1139/h10-017.
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Exercise-induced muscle damage (EIMD) leads to decrements in muscle performance and increases in intramuscular enzymes measured in the plasma, and to delayed onset of muscle soreness (DOMS), partly due to the activation of degradative pathways. It has been shown that milk-based carbohydrate-protein (CHO-P) can limit changes in markers of EIMD, possibly by attenuating protein degradation and (or) increasing protein synthesis. However, the timing of supplementation has received limited attention, and this may alter the response. This study examined the effects of acute milk-based CHO-P supplementation timing on the attenuation of EIMD. Four independent matched groups of 8 healthy males consumed milk-based CHO-P before (PRE), immediately after (POST), or 24 h after (TWENTY-FOUR) muscle-damaging exercise. Active DOMS, isokinetic muscle performance, reactive strength index (RSI), and creatine kinase (CK) were assessed immediately before and 24, 48, and 72 h after EIMD. POST and TWENTY-FOUR demonstrated a benefit in limiting changes in active DOMS, peak torque, and RSI over 48 h, compared with PRE. PRE showed a possible benefit in reducing increases in CK over 48 h and limiting changes in other variables over 72 h. Consuming milk-based CHO-P after muscle-damaging exercise is more beneficial in attenuating decreases in muscle performance and increases in active DOMS at 48 h than ingestion prior to exercise.
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Spoelder, Marcia, Lotte Koopmans, Yvonne A. W. Hartman, Coen C. W. G. Bongers, Merle C. A. Schoofs, Thijs M. H. Eijsvogels, and Maria T. E. Hopman. "Supplementation with Whey Protein, but Not Pea Protein, Reduces Muscle Damage Following Long-Distance Walking in Older Adults." Nutrients 15, no. 2 (January 10, 2023): 342. http://dx.doi.org/10.3390/nu15020342.
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Background: Adequate animal-based protein intake can attenuate exercise induced-muscle damage (EIMD) in young adults. We examined the effects of 13 days plant-based (pea) protein supplementation compared to whey protein and placebo on EIMD in active older adults. Methods: 47 Physically active older adults (60+ years) were randomly allocated to the following groups: (I) whey protein (25 g/day), (II) pea protein (25 g/day) or (III) iso-caloric placebo. Blood concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH), and skeletal muscle mass, muscle strength and muscle soreness were measured prior to and 24 h, 48 h and 72 h after a long-distance walking bout (20–30 km). Results: Participants walked 20–30 km and 2 dropped out, leaving n = 15 per subgroup. The whey group showed a significant attenuation of the increase in EIMD at 24 h post-exercise compared to the pea and placebo group (CK concentration: 175 ± 90 versus 300 ± 309 versus 330 ± 165, p = p < 0.001). No differences in LDH levels, muscle strength, skeletal muscle mass and muscle soreness were observed across groups (all p-values > 0.05). Conclusions: Thirteen days of pea protein supplementation (25 g/day) does not attenuate EIMD in older adults following a single bout of prolonged walking exercise, whereas the whey protein supplementation group showed significantly lower post-exercise CK concentrations.
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Baumert, P., C. E. Stewart, M. J. Lake, B. Drust, and R. M. Erskine. "Variations of collagen-encoding genes are associated with exercise-induced muscle damage." Physiological Genomics 50, no. 9 (September 1, 2018): 691–93. http://dx.doi.org/10.1152/physiolgenomics.00145.2017.
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We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I ( COL1A1, rs2249492 ; rs1800012 ), type II ( COL2A1, rs2070739 ), and type V (COL5A1, rs12722 ) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48 h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers ( rs1800012 ) and (major) T-allele homozygotes ( rs2249492 ) were generally weaker ( P ≤ 0.019); and (minor) A-allele carriers of COL2A1 ( P = 0.002) and (major) T-allele carriers of COL5A1 ( P = 0.004) SNPs reported greater muscle soreness, all compared with their respective major ( rs1800012 ; rs2070739 ) and minor ( rs2249492 ; rs12722 ) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle’s mechanical properties.
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Leeder, Jonathan D. C., Ken A. van Someren, David Gaze, Andrew Jewell, Nawed I. K. Deshmukh, Iltaf Shah, James Barker, and Glyn Howatson. "Recovery and Adaptation From Repeated Intermittent-Sprint Exercise." International Journal of Sports Physiology and Performance 9, no. 3 (May 2014): 489–96. http://dx.doi.org/10.1123/ijspp.2012-0316.
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Purpose:This investigation aimed to ascertain a detailed physiological profile of recovery from intermittentsprint exercise of athletes familiar with the exercise and to investigate if athletes receive a protective effect on markers of exercise-induced muscle damage (EIMD), inflammation, and oxidative stress after a repeated exposure to an identical bout of intermittent-sprint exercise.Methods:Eight well-trained male team-sport athletes of National League or English University Premier Division standard (mean ± SD age 23 ± 3 y, VO2max 54.8 ± 4.6 mL · kg−1 · min−1) completed the Loughborough Intermittent Shuttle Test (LIST) on 2 occasions, separated by 14 d. Maximal isometric voluntary contraction (MIVC), countermovement jump (CMJ), creatine kinase (CK), C-reactive protein (CRP), interleukin-6 (IL-6), F2-isoprostanes, and muscle soreness (DOMS) were measured before and up to 72 h after the initial and repeated LISTs.Results:MIVC, CMJ, CK, IL-6, and DOMS all showed main effects for time (P < .05) after the LIST, indicating that EIMD was present. DOMS peaked at 24 h after LIST 1 (110 ± 53 mm), was attenuated after LIST 2 (56 ± 39 mm), and was the only dependent variable to demonstrate a reduction in the second bout (P = .008). All other markers indicated that EIMD did not differ between bouts.Conclusion:Well-trained games players experienced EIMD after exposure to both exercise tests, despite being accustomed to the exercise type. This suggests that well-trained athletes receive a very limited protective effect from the first bout.
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Fernández-Lázaro, Diego, Juan Mielgo-Ayuso, Jesús Seco Calvo, Alfredo Córdova Martínez, Alberto Caballero García, and Cesar I. Fernandez-Lazaro. "Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review." Nutrients 12, no. 2 (February 15, 2020): 501. http://dx.doi.org/10.3390/nu12020501.
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Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.
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Caldas, Leonardo Carvalho, Rafael Barreira Salgueiro, Neil David Clarke, Jason Tallis, Valerio Garrone Barauna, and Lucas Guimaraes-Ferreira. "Effect of Caffeine Ingestion on Indirect Markers of Exercise-Induced Muscle Damage: A Systematic Review of Human Trials." Nutrients 14, no. 9 (April 23, 2022): 1769. http://dx.doi.org/10.3390/nu14091769.
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The effect of caffeine on mitigating exercise-induced muscle damage (EIMD) is still poorly understood, but it was hypothesized that caffeine could contribute to decreasing delayed onset muscle soreness, attenuating temporary loss of strength, and reducing circulating levels of blood markers of muscle damage. However, evidence is not conclusive and beneficial effects of caffeine ingestion on EIMD are not always observed. Factors, such as the type of exercise that induces muscle damage, supplementation protocol, and type of marker analyzed contribute to the differences between the studies. To expand knowledge on the role of caffeine supplementation in EIMD, this systematic review aimed to investigate the effect of caffeine supplementation on different markers of muscle damage. Fourteen studies were included, evaluating the effect of caffeine on indirect muscle damage markers, including blood markers (nine studies), pain perception (six studies), and MVC maximal voluntary contraction force (four studies). It was observed in four studies that repeated administration of caffeine between 24 and 72 h after muscle damage can attenuate the perception of pain in magnitudes ranging from 3.9% to 26%. The use of a single dose of caffeine pre-exercise (five studies) or post-exercise (one study) did not alter the circulating blood levels of creatine kinase (CK). Caffeine supplementation appears to attenuate pain perception, but this does not appear to be related to an attenuation of EIMD, per se. Furthermore, the effect of caffeine supplementation after muscle damage on strength recovery remains inconclusive due to the low number of studies found (four studies) and controversial results for both dynamic and isometric strength tests.
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Oxendale, Chelsea L., Craig Twist, Matthew Daniels, and Jamie Highton. "The Relationship Between Match-Play Characteristics of Elite Rugby League and Indirect Markers of Muscle Damage." International Journal of Sports Physiology and Performance 11, no. 4 (May 2016): 515–21. http://dx.doi.org/10.1123/ijspp.2015-0406.
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Purpose:While exercise-induced muscle damage (EIMD) after rugby league match play has been well documented, the specific match actions that contribute to EIMD are unclear. Accordingly, the purpose of this study was to investigate the positional demands of elite rugby league matches and examine their relationship with subsequent EIMD.Methods:Twenty-eight performances (from 17 participants) were captured using 10-Hz global positioning systems over 4 competitive matches. Upper- and lower-body neuromuscular fatigue, creatine kinase (CK), and perceived muscle soreness were assessed 24 h before and at 12, 36, and 60 h after matches.Results:High-intensity running was moderately higher in backs (6.6 ± 2.6 m/min) than in forwards (5.1 ± 1.6 m/min), whereas total collisions were moderately lower (31.1 ± 13.1 vs 54.1 ± 37.0). Duration (r = .90, CI: .77–.96) and total (r = .86, CI: .70–.95) and high-intensity distance covered (r = .76, CI: .51–.91) were associated (P < .05) with increased CK concentration postmatch. Total collisions and repeated high-intensity efforts were associated (P < .05) with large decrements in upper-body neuromuscular performance (r = –.48, CI: –.74 to .02; r = –.49, CI: –.77 to .05, respectively), muscle soreness (r = –.68, CI: –.87 to –.10, r = –.66, CI: –.89 to .21, respectively), and CK concentration (r = .67, CI: .42–.85; r = .73, CI: .51–.87, respectively). All EIMD markers returned to baseline within 60 h.Conclusion:Match duration, high-intensity running, and collisions were associated with variations in EIMD markers, suggesting that recovery is dependent on individual match demands.
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Hoffman, B. W., A. G. Cresswell, T. J. Carroll, and G. A. Lichtwark. "Muscle fascicle strains in human gastrocnemius during backward downhill walking." Journal of Applied Physiology 116, no. 11 (June 1, 2014): 1455–62. http://dx.doi.org/10.1152/japplphysiol.01431.2012.
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Extensive muscle damage can be induced in isolated muscle preparations by performing a small number of stretches during muscle activation. While typically these fiber strains are large and occur over long lengths, the extent of exercise-induced muscle damage (EIMD) observed in humans is normally less even when multiple high-force lengthening actions are performed. This apparent discrepancy may be due to differences in muscle fiber and tendon dynamics in vivo; however, muscle and tendon strains have not been quantified during muscle-damaging exercise in humans. Ultrasound and an infrared motion analysis system were used to measure medial gastrocnemius fascicle length and lower limb kinematics while humans walked backward, downhill for 1 h (inducing muscle damage), and while they walked briefly forward on the flat (inducing no damage). Supramaximal tibial nerve stimulation, ultrasound, and an isokinetic dynamometer were used to quantify the fascicle length-torque relationship pre- and 2 h postexercise. Torque decreased ∼23%, and optimal fascicle length shifted rightward ∼10%, indicating that EIMD occurred during the damage protocol even though medial gastrocnemius fascicle stretch amplitude was relatively small (∼18% of optimal fascicle length) and occurred predominantly within the ascending limb and plateau region of the length-torque curve. Furthermore, tendon contribution to overall muscle-tendon unit stretch was ∼91%. The data suggest the compliant tendon plays a role in attenuating muscle fascicle strain during backward walking in humans, thus minimizing the extent of EIMD. As such, in situ or in vitro mechanisms of muscle damage may not be applicable to EIMD of the human gastrocnemius muscle.
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Mielgo-Ayuso, Juan, and Diego Fernández-Lázaro. "Nutrition and Muscle Recovery." Nutrients 13, no. 2 (January 20, 2021): 294. http://dx.doi.org/10.3390/nu13020294.
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Kim, Choun-sub, and Maeng-kyu Kim. "Regional Differences of Mechanical Properties in a Biceps Brachii Following Eccentric Exercise." Exercise Science 30, no. 3 (August 31, 2021): 327–35. http://dx.doi.org/10.15857/ksep.2021.30.3.327.
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PURPOSE: This study aimed to examine the effects of eccentric exercise (ECC) on the indices of mechanical properties together with markers of exercise-induced muscle damage (EIMD) in different sites of the biceps brachii (BB) muscle.METHODS: ECC using an elbow joint was performed in 13 non-trained, college men. Global symptoms of EIMD were identified through changes in muscle soreness and serum creatine kinase (CK) activity, including muscle function following ECC. To evaluate regional EIMD, muscle swelling and tenderness as well as muscular echo intensity were measured at distal (4 cm above the elbow joint) and middle (30% of the distance from the antecubital crease to the acromion) sites within the BB muscle. A handheld myotonometer was used to estimate changes in mechanical properties, that is, oscillation frequency (F), dynamic stiffness (S), and relaxation time (R), of BB muscles after ECC.RESULTS: A significant difference in the major markers of EIMD, such as muscle soreness and serum CK activity, along with parameters of muscle function, was observed after ECC compared to baseline. Although all indirect markers of regional muscle damage demonstrated meaningful differences between before and after ECC, no statistically significant interaction between the distal and middle sites was observed in any of the markers. After ECC, both distal and middle sites showed significant changes in F, S, and R, but no statistical differences in changes in muscle mechanical properties were observed between localized muscle sites within BB muscles.CONCLUSIONS: Changes in mechanical properties, including regional muscle damage, seem to be uniformly influenced by different anatomical locations within the BB muscle, such as elbow flexors, following ECC.
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Tékus, Éva, Márk Váczi, Zoltán Horváth-Szalai, Andrea Ludány, Tamás Kőszegi, and Márta Wilhelm. "Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise." Journal of Human Kinetics 56, no. 1 (February 25, 2017): 99–108. http://dx.doi.org/10.1515/hukin-2017-0027.
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Abstract The present study investigated the acute effect of eccentric exercise on blood plasma actin, gelsolin (GSN) and orosomucoid (AGP) levels in untrained and moderately trained individuals, and their correlation with exercise induced muscle damage (EIMD) markers (CK, intensity of muscle soreness and maximal voluntary contraction torque deficit). Healthy physical education students (6 untrained, 12 moderately trained) participated in this research. Actin, GSN, AGP and CK levels were measured in blood plasma at baseline, immediately, 1 h, 6 h and 24 h post-exercise comprising 90 eccentric quadriceps contractions performed on a dynamometer. There was significant time main effect for GSN, AGP, CK and significant difference was found between baseline and the lowest value of post-exercise GSN (p < 0.05), as well as baseline and the highest value of post-exercise AGP (p < 0.05). Relationships were found between GSN levels and other indirect EIMD markers (between all GSN levels at post-exercise and CK activity at 6 h, p < 0.05; GSNMIN and muscle soreness at post-exercise, p < 0.04), GSN and AGP; however, actin did not correlate at any time points with GSN. Actin, GSN, AGP and CK responses after eccentric exercise do not seem sensitive to training status. The plasma actin level is used as an indicator of injury, however, our results suggest that it is not an accurate marker of EIMD, while plasma GSN concentrations show a better relationship with EIMD and the post-exercise inflammatory process. The elevated plasma AGP and the correlation between GSN and AGP seem to be promising for assessment of exercise-induced muscle injury.
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Parfenov, A. I., N. I. Belostotsky, S. G. Khomeriki, O. V. Akhmadullina, S. V. Bykova, E. A. Sabelnikova, and S. R. Dbar. "Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study." Terapevticheskii arkhiv 91, no. 2 (February 15, 2019): 25–31. http://dx.doi.org/10.26442/00403660.2019.02.000123.
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Aim. To evaluate the effectiveness of enteroprotector Rebamipide in the treatment of enteropathy with impaired membrane digestion (EIMD). Materials and methods. We examined 102 patients aged 18 to 50 years (41 men and 61 women) with clinical signs of irritable bowel syndrome (n=65), functional diarrhea (n=33), and functional constipation (n=4) according to Rome IV criteria (2016). The activities of glucoamylase (GA), maltase, sucrase and lactase were determined by Dahlquist-Trinder method in duodenal biopsies obtained during esophagogastroduodenoscopy. The control group consisted of 20 healthy people aged 23-47. They showed following average enzyme activity: lactase - 42±13 ng glucose on 1 mg of tissue per minute, GA - 509±176, maltase - 1735±446, sucrase - 136±35 ng glucose on 1 mg of tissue per minute. These numbers were taken as the norm. Results and discussion. The activity of the disaccharidases was reduced in 89.2% out of 102 patients, and they were diagnosed with EIMD. Thirteen patients with EIMD were recommended to maintain the FODMAP diet and take enteroprotector Rebamipide 100 mg 3 times a day for 12 weeks. After 3 months 11 patients reported decreased or no flatulence, abdominal pain, stool disorder; 2 patients reported no change. The activity of GA increased to an average of 149±82 (by 78%, p=0.016), maltase - to 864±472 (by 131%, p=0.0019), sucrase - 63±35 (by 95%, p=0.0041) and lactase - 10±8 ng glucose on 1 mg of tissue per minute. The activity of lactase did not change. Conclusion. We discovered a previously unknown phenomenon of the disaccharidases activity increase in duodenal mucosa and improved carbohydrates tolerance in the patients with EIMD taking Rebamipide in the dose 300 mg/day for 12 weeks.
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Azevedo, Klaus Porto, Júlia Aguillar Ivo Bastos, Ivo Vieira de Sousa Neto, Carlos Marcelo Pastre, and Joao Luiz Quagliotti Durigan. "Different Cryotherapy Modalities Demonstrate Similar Effects on Muscle Performance, Soreness, and Damage in Healthy Individuals and Athletes: A Systematic Review with Metanalysis." Journal of Clinical Medicine 11, no. 15 (July 30, 2022): 4441. http://dx.doi.org/10.3390/jcm11154441.
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Background: There are extensive studies focusing on non-invasive modalities to recover physiological systems after exercise-induced muscle damage (EIMD). Whole-body cryotherapy (WBC) and Partial-body cryotherapy (PBC) have been recommended for recovery after EIMD. However, to date, no systematic reviews have been performed to compare their effects on muscle performance and muscle recovery markers. Methods: This systematic review with metanalysis compared the effects of WBC and PBC on muscle performance, muscle soreness (DOMS), and markers of muscular damage following EIMD. We used Pubmed, Embase, PEDro, and Cochrane Central Register of Controlled Trials as data sources. Two independent reviewers verified the methodological quality of the studies. The studies were selected if they used WBC and PBC modalities as treatment and included muscle performance and muscle soreness (DOMS) as the primary outcomes. Secondary outcomes were creatine kinase and heart rate variability. Results: Six studies with a pooled sample of 120 patients were included. The methodological quality of the studies was moderate, with an average of 4.3 on a 0–10 scale (PEDro). Results: Both cryotherapy modalities induce similar effects without difference between them. Conclusion: WBC and PBC modalities have similar global responses on muscle performance, soreness, and markers of muscle damage.
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Sánchez Díaz, Mariana, Adrián Martín-Castellanos, Valentín E. Fernández-Elías, Olga López Torres, and Jorge Lorenzo Calvo. "Effects of Polyphenol Consumption on Recovery in Team Sport Athletes of Both Sexes: A Systematic Review." Nutrients 14, no. 19 (October 1, 2022): 4085. http://dx.doi.org/10.3390/nu14194085.
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Previous studies have shown that polyphenol consumption enhances recovery of the muscle after exercise-induced muscle damage (EIMD). However, EIMD markers have not been studied by sport type. The main aim of this research was to perform a systematic review to determine the efficacy of polyphenolic consumption in increasing muscle recovery for performing team sport skills. Eligible studies included, following PICOS structure, presented at least one of the following outcomes: maximal isometric voluntary contraction (MVIC); countermovement jump (CMJ); delayed onset muscle soreness (DOMS); 20 m sprint test; creatine kinase (CK); and C-reactive protein (hsCRP). A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. The risk of bias was assessed using the PEDro scale tool. The review showed a possibly positive impact of polyphenol consumption on recovery after EIMD in team sports athletes. No differences were found between sexes. Considering the limitations, there is moderate to very low certainty of polyphenol supplementation effects on recovery of team sport females and males. A dose of 60 mL/day, divided into two times per day, ingested for >7 days may present positive effects on muscle function and muscle soreness in team sport athletes. However, further investigation is required, specifically in females.
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Martin-Rincon, Marcos, Miriam Gelabert-Rebato, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Laura Lopez-Rios, Julia C. Wiebe, et al. "Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise." Nutrients 12, no. 3 (February 26, 2020): 614. http://dx.doi.org/10.3390/nu12030614.
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Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.
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Lima, Leonardo C. R., Renan V. Barreto, Natália M. Bassan, Camila C. Greco, and Benedito S. Denadai. "Consumption of An Anthocyanin-Rich Antioxidant Juice Accelerates Recovery of Running Economy and Indirect Markers of Exercise-Induced Muscle Damage Following Downhill Running." Nutrients 11, no. 10 (September 23, 2019): 2274. http://dx.doi.org/10.3390/nu11102274.
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This study examined the effects of anthocyanin-rich antioxidant juice (AJ) on the recovery of exercise-induced muscle damage (EIMD) and the running economy (RE) following downhill running (DHR). Thirty healthy young men were randomly divided into two blinded groups and consumed either AJ or placebo (PLA) for nine days (240 mL twice-a-day). On day 5, the participants from both groups ran downhill (−15%) for 30 min at 70% of their maximal oxygen uptake (VO2max) speeds. The changes in RE (oxygen uptake (VO2) and perceived effort (PE) during 5-min runs at 80%VO2max) and EIMD (isometric peak torque (IPT), muscle soreness (SOR) and serum creatine kinase activity (CK)) were compared over time and between the groups on the 4 days following DHR. VO2 and PE increased (p < 0.05) immediately following DHR for both groups and remained elevated for PLA until 48h post-DHR while fully recovering 24 h post-DHR for AJ. SOR was greater (p < 0.05) for PLA throughout the study. CK increased for both groups and was greater (p < 0.05) for PLA at 96 h post-DHR. IPT decreased for both groups but recovered faster for AJ (72 h) compared to PLA (no full recovery). AJ accelerated recovery of RE and EIMD and should be used in specific contexts, but not chronically.
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Jo, Edward, Rachel Bartosh, Alexandra T. Auslander, Dean Directo, Adam Osmond, and Michael WH Wong. "Post-Exercise Recovery Following 30-Day Supplementation of Trans-Resveratrol and Polyphenol-Enriched Extracts." Sports 7, no. 10 (October 20, 2019): 226. http://dx.doi.org/10.3390/sports7100226.
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Background: The purpose of this study was to investigate the effects of 30-day consumption of trans-resveratrol and polyphenol-enriched extracts on indices of exercise-induced muscle damage (EIMD) and performance following eccentric-loaded resistance exercise (ECRE). Methods: Following 30 days of resveratrol-polyphenol (RES) (n = 10) or placebo control (CTL) (n = 12) supplementation, subjects performed a bout of ECRE to induce EIMD. EIMD biomarkers, perceived soreness, pain threshold and tolerance, range of motion, and performance were measured before and 24 and 48 h after ECRE. Results: CTL subjects demonstrated increased soreness at 24 (p = 0.02) and 48 h (p = 0.03) post-ECRE, while RES subjects reported increased soreness at 24 h post-ECRE (p = 0.0003). CTL subjects exhibited decreased pain threshold in the vastus lateralis at 24 h post-ECRE (p = 0.03). CTL subjects also displayed decreased pain tolerance in the vastus intermedius at 24 h post-ECRE (p = 0.03) and the vastus lateralis at 24 (p = 0.003) and 48 h (p = 0.003). RES participants showed no change in pain threshold or tolerance from baseline. CTL subjects showed a decrease in mean (p = 0.04) and peak power (p = 0.04) at 24 h post-ECRE, while RES participants demonstrated no changes from baseline. No between-group differences were observed for the changes in serum creatine kinase. Serum C-reactive protein increased similarly in both groups at 24 h post-ECRE (p < 0.002), remaining elevated in CTL subjects while RES participants demonstrated a decline from 24 to 48 h (p = 0.04). Serum interleukin 6 increased at 24 h post-ECRE in both groups (p < 0.003) followed by a decrease from 24 to 48 h, returning to baseline levels only for RES subjects. Conclusion: Trans-resveratrol and polyphenol-enriched extract supplementation may support the attenuation of soreness and inflammation and improve performance recovery following ECRE without modulation of indirect biomarkers of EIMD.
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Ostojic, Sergej M. "Exercise-induced mitochondrial dysfunction: a myth or reality?" Clinical Science 130, no. 16 (July 7, 2016): 1407–16. http://dx.doi.org/10.1042/cs20160200.
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Exercise-induced mitochondrial dysfunction (EIMD) could be a key proxy for negative outcomes of exhaustive exercise, being a pathophysiological substrate of heart abnormalities, chronic fatigue syndrome (CFS) or muscle degeneration in experimental and clinical medicine.
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Hunt, Julie E. A., Mariana O. C. Coelho, Sean Buxton, Rachel Butcher, Daniel Foran, Daniel Rowland, William Gurton, et al. "Consumption of New Zealand Blackcurrant Extract Improves Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men and Women: A Double-Blind Randomised Trial." Nutrients 13, no. 8 (August 21, 2021): 2875. http://dx.doi.org/10.3390/nu13082875.
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Background: Blackcurrant is rich in anthocyanins that may protect against exercise-induced muscle damage (EIMD) and facilitate a faster recovery of muscle function. We examined the effects of New Zealand blackcurrant (NZBC) extract on indices of muscle damage and recovery following a bout of strenuous isokinetic resistance exercise. Methods: Using a double-blind, randomised, placebo controlled, parallel design, twenty-seven healthy participants received either a 3 g·day−1 NZBC extract (n = 14) or the placebo (PLA) (n = 13) for 8 days prior to and 4 days following 60 strenuous concentric and eccentric contractions of the biceps brachii muscle on an isokinetic dynamometer. Muscle soreness (using a visual analogue scale), maximal voluntary contraction (MVC), range of motion (ROM) and blood creatine kinase (CK) were assessed before (0 h) and after (24, 48, 72 and 96 h) exercise. Results: Consumption of NZBC extract resulted in faster recovery of baseline MVC (p = 0.04), attenuated muscle soreness at 24 h (NZBC: 21 ± 10 mm vs. PLA: 40 ± 23 mm, p = 0.02) and 48 h (NZBC: 22 ± 17 vs. PLA: 44 ± 26 mm, p = 0.03) and serum CK concentration at 96 h (NZBC: 635 ± 921 UL vs. PLA: 4021 ± 4319 UL, p = 0.04) following EIMD. Conclusions: Consumption of NZBC extract prior to and following a bout of eccentric exercise attenuates muscle damage and improves functional recovery. These findings are of practical importance in recreationally active and potentially athletic populations, who may benefit from accelerated recovery following EIMD.
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Molina, Renato, and Benedito Sérgio Denadai. "Muscle damage slows oxygen uptake kinetics during moderate-intensity exercise performed at high pedal rate." Applied Physiology, Nutrition, and Metabolism 36, no. 6 (December 2011): 848–55. http://dx.doi.org/10.1139/h11-109.
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This study aimed to investigate the dependence of oxygen uptake (VO2) kinetics on pedal cadence during moderate-intensity exercise following exercise-induced muscle damage (EIMD). Twenty untrained males were randomly assigned to a 50 revolution per minute (rpm) (age, 23.3 ± 1.8 years; VO2max, 38.9 ± 2.8 mL·kg–1·min–1) or 100 rpm group (age, 24.4 ± 3.5 years, VO2max, 42.9 ± 4.3 mL·kg–1·min–1). Participants completed “step” tests to moderate-intensity exercise from an unloaded baseline on a cycle ergometer before (baseline) and at 24 and 48 h after muscle-damaging exercise (10 sets of 10 eccentric contractions performed on an isokinetic dynamometer with a 2-min rest between each set). Pedal cadence was kept constant throughout each cycling trial (50 or 100 rpm). There were no changes in phase II pulmonary VO2 kinetics following EIMD for the 50 rpm group (baseline = 35 ± 4 s; 24 h = 35 ± 7 s; and 48 h = 36 ± 9 s). However, the phase II VO2 was significantly greater at 24 h (59 ± 27 s) compared with baseline (39 ± 6 s) and 48 h (40 ± 9 s) for the 100 rpm group. It is concluded that the effects of EIMD on phase II VO2 kinetics during moderate-intensity cycling exercise is dependent on pedal cadence. The slower VO2 kinetics after muscle damage suggests that type II fibers are involved during transition to moderate-intensity exercise at high pedal cadence.
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Qu, Chaoyi, Zhaozhao Wu, Minxiao Xu, Fei Qin, Yanan Dong, Zhongwei Wang, and Jiexiu Zhao. "Cryotherapy Models and Timing-Sequence Recovery of Exercise-Induced Muscle Damage in Middle- and Long-Distance Runners." Journal of Athletic Training 55, no. 4 (April 1, 2020): 329–35. http://dx.doi.org/10.4085/1062-6050-529-18.
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Context Among sports-recovery methods, cold-water immersion (CWI), contrast-water therapy (CWT), and whole-body cryotherapy (WBC) have been applied widely to enhance recovery after strenuous exercise. However, the different timing effects in exercise-induced muscle damage (EIMD) after these recovery protocols remain unknown. Objective To compare the effects of CWI, CWT, and WBC on the timing-sequence recovery of EIMD through different indicator responses. Design Crossover study. Setting Laboratory. Patients or Other Participants Twelve male middle- and long-distance runners from the Beijing Sport University (age = 21.00 ± 0.95 years). Intervention(s) Participants were treated with different recovery methods (control [CON], CWI, CWT, WBC) immediately postexercise and at 24, 48, and 72 hours postexercise. Main Outcome Measure(s) We measured perceived sensation using a visual analog scale (VAS), plasma creatine kinase (CK) activity, plasma C-reactive protein (CRP) activity, and vertical-jump height (VJH) pre-exercise, immediately postexercise, and at 1, 24, 48, 72, and 96 hours postexercise. Results For the VAS score and CK activity, WBC exhibited better timing-sequence recovery effects than CON and CWI (P < .05), but the CWT demonstrated better effects than CON (P < .05). The CRP activity was lower after WBC than after the other interventions (P < .05). The VJH was lower after WBC than after CON and CWI (P < .05). Conclusions The WBC positively affected VAS, CK, CRP, and VJH associated with EIMD. The CWT and CWI also showed positive effects. However, for the activity and timing-sequence effect, CWT had weaker effects than WBC.
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Martínez-Ferrán, María, Víctor Cuadrado-Peñafiel, Juan Manuel Sánchez-Andreo, Marta Villar-Lucas, Mónica Castellanos-Montealegre, Agustín Rubio-Martín, Carlos Romero-Morales, Soraya Casla-Barrio, and Helios Pareja-Galeano. "Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial." Nutrients 14, no. 21 (November 3, 2022): 4635. http://dx.doi.org/10.3390/nu14214635.
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Considering the existing controversy over the possible role of acute antioxidant vitamins in reducing exercise-induced muscle damage (EIMD), this doubled-blind, randomized and controlled trial aimed to determine whether supplementation with vitamins C and E could mitigate the EIMD in endurance-trained runners (n = 18). The exercise protocol involved a warm-up followed by 6 to 8 bouts of 1 km running at 75% maximum heart rate (HRmax). Two hours before the exercise protocol, participants took the supplementation with vitamins or placebo, and immediately afterwards, blood lactate, rate of perceived exertion and performance were assessed. At 24 h post-exercise, CK, delayed onset muscle soreness and performance were determined (countermovement jump, squat jump and stiffness test). The elastic index and vertical stiffness were calculated using a stiffness test. Immediately after the exercise protocol, all participants showed improved maximum countermovement jump, which only persisted after 24 h in the vitamin group (p < 0.05). In both groups, squat jump height was significantly greater (p < 0.05) immediately after exercise and returned to baseline values after 24 h. The elastic index increased in the vitamin group (p < 0.05), but not in the placebo group. In both groups, lactate levels increased from pre- to immediately post-exercise (p < 0.05), and CK increased from pre- to 24 h post-exercise (p < 0.05). No significant differences between groups were observed in any of the variables (p > 0.05). Vitamin C and E supplementation does not seem to help with EIMD in endurance-trained individuals.
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Lin, Ching-Hung, Yi-An Lin, Shu-Li Chen, Mei-Chich Hsu, and Cheng-Chen Hsu. "American Ginseng Attenuates Eccentric Exercise-Induced Muscle Damage via the Modulation of Lipid Peroxidation and Inflammatory Adaptation in Males." Nutrients 14, no. 1 (December 25, 2021): 78. http://dx.doi.org/10.3390/nu14010078.
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Exercise-induced muscle damage (EIMD) is characterized by a reduction in functional performance, disruption of muscle structure, production of reactive oxygen species, and inflammatory reactions. Ginseng, along with its major bioactive component ginsenosides, has been widely employed in traditional Chinese medicine. The protective potential of American ginseng (AG) for eccentric EIMD remains unclear. Twelve physically active males (age: 22.4 ± 1.7 years; height: 175.1 ± 5.7 cm; weight: 70.8 ± 8.0 kg; peak oxygen consumption [V˙O2peak] 54.1 ± 4.3 mL/kg/min) were administrated by AG extract (1.6 g/day) or placebo (P) for 28 days and subsequently challenged by downhill (DH) running (−10% gradient and 60% V˙O2peak). The levels of circulating 8-iso-prostaglandin F 2α (PGF2α), creatine kinase (CK), interleukin (IL)-1β, IL-4, IL-10, and TNF-α, and the graphic pain rating scale (GPRS) were measured before and after supplementation and DH running. The results showed that the increases in plasma CK activity induced by DH running were eliminated by AG supplementation at 48 and 72 h after DH running. The level of plasma 8-iso-PGF2α was attenuated by AG supplementation immediately (p = 0.01 and r = 0.53), 2 h (p = 0.01 and r = 0.53) and 24 h (p = 0.028 and r = 0.45) after DH running compared with that by P supplementation. Moreover, our results showed an attenuation in the plasma IL-4 levels between AG and P supplementation before (p = 0.011 and r = 0.52) and 72 h (p = 0.028 and r = 0.45) following DH running. Our findings suggest that short-term supplementation with AG alleviates eccentric EIMD by decreasing lipid peroxidation and promoting inflammatory adaptation.
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Doering, Thomas M., Peter R. Reaburn, Nattai R. Borges, Gregory R. Cox, and David G. Jenkins. "The Effect of Higher Than Recommended Protein Feedings Post-Exercise on Recovery Following Downhill Running in Masters Triathletes." International Journal of Sport Nutrition and Exercise Metabolism 27, no. 1 (February 2017): 76–82. http://dx.doi.org/10.1123/ijsnem.2016-0079.
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Following exercise-induced muscle damage (EIMD), masters athletes take longer to recover than younger athletes. The purpose of this study was to determine the effect of higher than recommended postexercise protein feedings on the recovery of knee extensor peak isometric torque (PIT), perceptions of recovery, and cycling time trial (TT) performance following EIMD in masters triathletes. Eight masters triathletes (52 ± 2 y, V̇O2max, 51.8 ± 4.2 ml•kg-1•min-1) completed two trials separated by seven days in a randomized, doubleblind, crossover study. Trials consisted of morning PIT testing and a 30-min downhill run followed by an eight-hour recovery. During recovery, a moderate (MPI; 0.3 g•kg-1•bolus-1) or high (0.6 g•kg-1•bolus-1) protein intake (HPI) was consumed in three bolus feedings at two hour intervals commencing immediately postexercise. PIT testing and a 7 kJ•kg-1 cycling TT were completed postintervention. Perceptions of recovery were assessed pre- and postexercise. The HPI did not significantly improve recovery compared with MPI (p > .05). However, comparison of within-treatment change shows the HPI provided a moderate beneficial effect (d = 0.66), attenuating the loss of afternoon PIT (-3.6%, d = 0.09) compared with the MPI (-8.6%, d = 0.24). The HPI provided a large beneficial effect (d = 0.83), reducing perceived fatigue over the eight-hour recovery (d = 1.25) compared with the MPI (d = 0.22). Despite these effects, cycling performance was unchanged (HPI = 2395 ± 297 s vs. MPI = 2369 ± 278 s; d = 0.09). In conclusion, doubling the recommended postexercise protein intake did not significantly improve recovery in masters athletes; however, HPI provided moderate to large beneficial effects on recovery that may be meaningful following EIMD.
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Burgos, José, Aitor Viribay, Julio Calleja-González, Diego Fernández-Lázaro, Jurgi Olasagasti-Ibargoien, Jesús Seco-Calvo, and Juan Mielgo-Ayuso. "Long-Term Combined Effects of Citrulline and Nitrate-Rich Beetroot Extract Supplementation on Recovery Status in Trained Male Triathletes: A Randomized, Double-Blind, Placebo-Controlled Trial." Biology 11, no. 1 (January 4, 2022): 75. http://dx.doi.org/10.3390/biology11010075.
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Citrulline (CIT) and nitrate-rich beetroot extract (BR) are widely studied ergogenic aids. Nevertheless, both supplements have been studied in short-term trials and separately. To the best of the authors’ knowledge, the effects of combining CIT and BR supplementation on recovery status observed by distance covered in the Cooper test, exercise-induced muscle damage (EIMD) and anabolic/catabolic hormone status have not been investigated to date. Therefore, the main purpose of this research was to assess the effect of the long-term (9 weeks) mixture of 3 g/day of CIT plus 2.1 g/day of BR (300 mg/day of nitrates (NO3−)) supplementation on recovery by distance covered in the Cooper test, EIMD markers (urea, creatinine, AST, ALT, GGT, LDH and CK) and anabolic/catabolic hormones (testosterone, cortisol and testosterone/cortisol ratio (T/C)) in male trained triathletes. Thirty-two triathletes were randomized into four different groups of eight triathletes in this double-blind, placebo-controlled trial: placebo group (PLG), CIT group (CITG; 3 g/day of CIT), BR group (BRG; 2.1 g/day of BR (300 mg/day of NO3−)) and CIT-BR group (CIT-BRG; 3 g/day of CIT plus 2.1 g/day of BR (300 mg/day of NO3−)). Distance covered in the Cooper test and blood samples were collected from all participants at baseline (T1) and after 9 weeks of supplementation (T2). There were no significant differences in the interaction between group and time in EIMD markers (urea, creatinine, AST, ALT, GGT, LDH and CK) (p > 0.05). However, significant differences were observed in the group-by-time interaction in distance covered in the Cooper test (p = 0.002; η2p = 0.418), cortisol (p = 0.044; η2p = 0.247) and T/C (p = 0.005; η2p = 0.359). Concretely, significant differences were observed in distance covered in the Cooper test percentage of change (p = 0.002; η2p = 0.418) between CIT-BRG and PLG and CITG, in cortisol percentage change (p = 0.049; η2p = 0.257) and in T/C percentage change (p = 0.018; η2p = 0.297) between CIT-BRG and PLG. In conclusion, the combination of 3 g/day of CIT plus 2.1 g/day of BR (300 mg/day of NO3−) supplementation for 9 weeks did not present any benefit for EIMD. However, CIT + BR improved recovery status by preventing an increase in cortisol and showing an increase in distance covered in the Cooper test and T/C.
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Arribalzaga, Soledad, Aitor Viribay, Julio Calleja-González, Diego Fernández-Lázaro, Arkaitz Castañeda-Babarro, and Juan Mielgo-Ayuso. "Relationship of Carbohydrate Intake during a Single-Stage One-Day Ultra-Trail Race with Fatigue Outcomes and Gastrointestinal Problems: A Systematic Review." International Journal of Environmental Research and Public Health 18, no. 11 (May 27, 2021): 5737. http://dx.doi.org/10.3390/ijerph18115737.
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Due to the high metabolic and physical demands in single-stage one-day ultra-trail (SOUT) races, athletes should be properly prepared in both physical and nutritional aspects in order to delay fatigue and avoid associated difficulties. However, high carbohydrate (CHO) intake would seem to increase gastrointestinal (GI) problems. The main purpose of this systematic review was to evaluate CHO intake during SOUT events as well as its relationship with fatigue (in terms of internal exercise load, exercise-induced muscle damage (EIMD) and post-exercise recovery) and GI problems. A structured search was carried out in accordance with PRISMA guidelines in the following: Web of Science, Cochrane Library and Scopus databases up to 16 March 2021. After conducting the search and applying the inclusion/exclusion criteria, eight articles in total were included in this systematic review, in all of which CHO intake involved gels, energy bars and sports drinks. Two studies associated higher CHO consumption (120 g/h) with an improvement in internal exercise load. Likewise, these studies observed that SOUT runners whose intake was 120 g/h could benefit by limiting the EIMD observed by CK (creatine kinase), LDH (lactate dehydrogenase) and GOT (aspartate aminotransferase), and also improve recovery of high intensity running capacity 24 h after a trail marathon. In six studies, athletes had GI symptoms between 65–82%. In summary, most of the runners did not meet CHO intake standard recommendations for SOUT events (90 g/h), while athletes who consumed more CHO experienced a reduction in internal exercise load, limited EIMD and improvement in post-exercise recovery. Conversely, the GI symptoms were recurrent in SOUT athletes depending on altitude, environmental conditions and running speed. Therefore, a high CHO intake during SOUT events is important to delay fatigue and avoid GI complications, and to ensure high intake, it is necessary to implement intestinal training protocols.
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Fernández-Landa, Julen, Diego Fernández-Lázaro, Julio Calleja-González, Alberto Caballero-García, Alfredo Córdova, Patxi León-Guereño, and Juan Mielgo-Ayuso. "Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes." Biomolecules 10, no. 1 (January 15, 2020): 140. http://dx.doi.org/10.3390/biom10010140.
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Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of 10 weeks of CrM plus HMB supplementation on EIMD and anabolic/catabolic hormones. This study was a double-blind, placebo-controlled trial where participants (n = 28) were randomized into four different groups: placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7). Before (baseline, T1) and after 10 weeks of supplementation (T2), blood samples were collected from all rowers. There were no significant differences in the EIMD markers (aspartate aminotransferase, lactate dehydrogenase, and creatine kinase) among groups. However, we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = −63.85% vs. CrMG + HMBG = −37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation.
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Tanabe, Yoko, Naoto Fujii, and Katsuhiko Suzuki. "Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans." Nutrients 14, no. 1 (December 24, 2021): 70. http://dx.doi.org/10.3390/nu14010070.
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Dietary supplements are widely used as a nutritional strategy to improve and maintain performance and achieve faster recovery in sports and exercise. Exercise-induced muscle damage (EIMD) is caused by mechanical stress and subsequent inflammatory responses including reactive oxygen species and cytokine production. Therefore, dietary supplements with anti-inflammatory and antioxidant properties have the potential to prevent and reduce muscle damage and symptoms characterized by loss of muscle strength and delayed-onset muscle soreness (DOMS). However, only a few supplements are considered to be effective at present. This review focuses on the effects of dietary supplements derived from phytochemicals and listed in the International Olympic Committee consensus statement on muscle damage evaluated by blood myofiber damage markers, muscle soreness, performance, and inflammatory and oxidative stress markers. In this review, the effects of dietary supplements are also discussed in terms of study design (i.e., parallel and crossover studies), exercise model, and such subject characteristics as physical fitness level. Future perspectives and considerations for the use of dietary supplements to alleviate EIMD and DOMS are also discussed.
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Choudhuri, Atreyee, Ajay Singh Amera, Amarendra Haldar, and Zeeshan Ali. "A Review on the Effect of Nutrition on Exercise-Induced Muscle Damage (EIMD)." SSR Institute of International Journal of Life Sciences 8, no. 5 (September 2022): 3097–101. http://dx.doi.org/10.21276/ssr-iijls.2022.8.5.4.
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Jo, Hyeon-deok, Choun-sub Kim, and Maeng-kyu Kim. "Effects of Transdermal Methylsulfonylmethane on Muscle Damage and Recovery Following Eccentric Exercise." Exercise Science 30, no. 2 (May 31, 2021): 158–66. http://dx.doi.org/10.15857/ksep.2021.30.2.158.
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PURPOSE:The present study aimed to investigate the effects of transdermal application of methylsulfonylmethane (MSM) on muscle damage and recovery following eccentric exercise in young men.METHODS: Eleven college-aged men without any cardiovascular or orthopedic disorders underwent two sessions consisting of a control session (CS) and an experimental session (ES) in a random order with at least 2 weeks of wash-out between the sessions. The participants performed 30 maximal eccentric exercises involving their non-dominant elbow flexors in each session. Circumference, muscle soreness, range of motion, maximal voluntary isometric contraction (MVIC), and muscular echo intensity (EI) were measured to evaluate the changes in the level of exercise-induced muscle damage (EIMD). All measurements were performed at 24, 48, 72, and 96 hours after exercise and also immediately before and after exercise.RESULTS:Transdermal application of MSM in ES attenuated muscle swelling and decreased MVIC after eccentric exercise when compared with CS. Muscle soreness and EI tended to increase less rapidly and decrease more rapidly in ES than in CS.CONCLUSIONS: Transdermal application of MSM may induce relatively positive effects on EIMD and recovery following eccentric exercise when compared with the treatment that has been widely used previously.