Academic literature on the topic 'Eif6'
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Journal articles on the topic "Eif6"
Smolle, Maria Anna, Piotr Czapiewski, Sylwia Lapińska-Szumczyk, Hanna Majewska, Anna Supernat, Anna Zaczek, Wojciech Biernat, Nicole Golob-Schwarzl, and Johannes Haybaeck. "The Prognostic Significance of Eukaryotic Translation Initiation Factors (eIFs) in Endometrial Cancer." International Journal of Molecular Sciences 20, no. 24 (December 6, 2019): 6169. http://dx.doi.org/10.3390/ijms20246169.
Full textWang, Xiaoyan, Guangchao Xu, Fangyingnan Zhang, Yating Wei, Jiawen Deng, Lan Mu, Jinqing He, et al. "eIF6 modulates skin wound healing by upregulating keratin 6B." Stem Cells Translational Medicine 13, no. 11 (October 15, 2024): 1101–12. http://dx.doi.org/10.1093/stcltm/szae064.
Full textJivotovskaya, Antonina V., Leoš Valášek, Alan G. Hinnebusch, and Klaus H. Nielsen. "Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast." Molecular and Cellular Biology 26, no. 4 (February 15, 2006): 1355–72. http://dx.doi.org/10.1128/mcb.26.4.1355-1372.2006.
Full textHarish, Kavya Meena, Poonam Roshan, Aparna Biswas, Stella Anagnos, Riley Luebbers, and Sofia Origanti. "Abstract 7078: Targeting eIF6 to modulate ribosomal subunit association dynamics in cancers." Cancer Research 84, no. 6_Supplement (March 22, 2024): 7078. http://dx.doi.org/10.1158/1538-7445.am2024-7078.
Full textGolob-Schwarzl, Nicole, Christina Wodlej, Florian Kleinegger, Margit Gogg-Kamerer, Anna Maria Birkl-Toeglhofer, Johannes Petzold, Ariane Aigelsreiter, Michael Thalhammer, Young Nyun Park, and Johannes Haybaeck. "Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer." Journal of Cancer Research and Clinical Oncology 145, no. 11 (October 4, 2019): 2699–711. http://dx.doi.org/10.1007/s00432-019-03030-x.
Full textSchatz, Christoph, Susanne Sprung, Volker Schartinger, Helena Codina-Martínez, Matt Lechner, Mario Hermsen, and Johannes Haybaeck. "Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)." Cancers 13, no. 22 (November 11, 2021): 5649. http://dx.doi.org/10.3390/cancers13225649.
Full textPesce, Elisa, Annarita Miluzio, Lorenzo Turcano, Claudia Minici, Delia Cirino, Piera Calamita, Nicola Manfrini, et al. "Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits." Cells 9, no. 1 (January 10, 2020): 172. http://dx.doi.org/10.3390/cells9010172.
Full textHarish, Kavya Meena, Aparna Biswas, Poonam Roshan, and Sofia Origanti. "Abstract 3719: Targeting the eIF6 and 60S ribosomal subunit interaction interface in cancers." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3719. http://dx.doi.org/10.1158/1538-7445.am2023-3719.
Full textOyarbide, Usua, Valentino Bezzerri, Morgan Staton, Christian Boni, Arish Shah, Marco Cipolli, Eliezer Calo, and Seth J. Corey. "Eif6 Dosage Alleviates Activation of the Tp53 Pathway in Sbds-Deficient Cells: A Mechanism for Somatic Genetic Rescue in Shwachman-Diamond Syndrome." Blood 144, Supplement 1 (November 5, 2024): 4090. https://doi.org/10.1182/blood-2024-209812.
Full textDe Marco, N., C. Campanella, and R. Carotenuto. "In X. laevis embryos high levels of the anti-apoptotic factor p27BBP/eIF6 are stage-dependently found in BrdU and TUNEL-reactive territories." Zygote 19, no. 2 (July 27, 2010): 157–63. http://dx.doi.org/10.1017/s0967199410000213.
Full textDissertations / Theses on the topic "Eif6"
RUSSO, ARIANNA. "Increasing Eukaryotic Initiation Factor (eIF6) gene dosage stimulates global translation and induces a transcriptional and metabolic rewiring that blocks Programmed Cell Death." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/97190.
Full textSCAGLIOLA, ALESSANDRA. "EIF6 PHOSPHORYLATION ON SER235 IS REQUIRED FOR MAMMALIAN DEVELOPMENT AND FOR T-CELL LYMPHOMAGENESIS, ESTABLISHING A FUNCTIONAL NETWORK BETWEEN TRANSLATION AND SENESCENCE." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/631917.
Full textBertrand, Alexis. "Caractérisation fonctionnelle de mutations somatiques compensatrices d'elF6 dans le contexte du syndrome de Shwachman- Diamond." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL089.
Full textShwachman Diamond syndrome (SDS) is a rare genetic ribosomopathy leading to impaired protein synthesis, which causes numerous symptoms including bone marrow failure and neutropenia that can evolve to myelodysplasia syndrome or acute myeloid leukaemia. Biallelic mutations in the SBDS gene are responsible of above 90% of the SDS cases and we recently identified biallelic EFL1 mutations as a novel cause of SDS. SBDS together with EFL1 remove the anti-association factor elF6 from the pre60S ribosomal subunit, allowing its interaction with the 40S subunit to form the mature ribosome 80S. Natural acquisition of somatic genetic events over time participâtes to age-related diseases and cancer development. However, in Mendelian diseases these events can, in rare case, counteract the deleterious effect of the germline mutation and provide a sélective advantage to the somatically modified cells, a phenomenon dubbed Somatic Genetic Rescue (SGR). We recently showed that several somatic genetic events affecting the expression or function of elF6 are frequently detected in blood clones from SDS patients but not in healthy individuals, suggesting a mechanism of SGR. While most of these somatic mutations induce elF6 destabilization or EIF6 haploinsufficiency, one récurrent mutation (N106S) did not affect the expression of elF6 but rather impact its ability to interact with the 60S subunit. In order to further investigate the functional conséquences of ElF6 haploinsufficiency and N106S mutation in a context of SDS, I introduced via CRISPR/Cas9 these mutations in immortalized fibroblastic cell line from SDS patients and control. These original cellular models hâve made it possible to détermine the impact of the N106S mutation on the localisation and function of elF6 and also to clarify the effects of these mutations on several aspects of cellular fitness, in particular ribosome biogenesis, translation rate and cell prolifération. Overall, the development of these cellular models has helped to characterise how the somatic N106S mutation and elF6 haploinsufficiency confer a sélective advantage in cells déficient in SBDS or EFL1
Crespillo, Casado Ana. "The eIF2 phosphatase : characterization and modulation." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283601.
Full textMurphy, Patrick. "Characterisation of critical interactions between translation factors eIF2 and eIF2B." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/characterisation-of-critical-interactions-between-translation-factors-eif2-and-eif2b(9138d7c8-34b1-4489-8048-a2ac45ef8533).html.
Full textGuillon, Laurent. "Etude des facteurs du démarrage de la traduction eIF5B et eIF3." Phd thesis, Ecole Polytechnique X, 2008. http://pastel.archives-ouvertes.fr/pastel-00004650.
Full textWang, Xiaoshan. "Regulation of eIF3-Paip1 interaction by extracellular stimuli and phosphorylation status." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86958.
Full textL'interaction tertiaire entre la protéine PABP (poly(A)-binding protein), le facteur d'initiation de la traduction eucaryote 4G (eIF4G), et la queue poly(A) des ARN messagers, stimule l'initiation de la traduction. De plus, l'interaction entre la protéine qui interagit avec PABP, Paip1 (PABP-interacting protein 1), et le facteur d'initiation de la traduction eucaryote 3 (eIF3) (par sa sous-unité g), induit la traduction de façon plus élevée. Dans cette thèse, nous démontrons que l'interaction entre l'eIF3 et Paip1 est régulée par la présence d'acides aminées, et que cette interaction est dépendante de la voie signalétique contrôlée par mTORC1. En effet, les inhibiteurs de cette voie signalétique comme la rapamycin et la wortmannin bloquent l'interaction. Comme Paip1 s'attache directement à la sous-unité g de l'eIF3 et que cette dernière peut être phosphorylée sur la thréonine 41 ou la sérine 42, nous avons étudié le rôle la phosphorylation de eIF3g sur l'interaction entre les deux protéines. Nous démontrons que cette phosphorylation n'est pas stimulée par l'addition d'acides aminées et qu'elle n'induit pas une plus grande interaction entre eIF3 et Paip1. Par contre, nous observons que la kinase S6K (S6 ribosomal protein kinase), régule de façon positive l'interaction entre eIF3 et Paip1, et nous suggérons que cette kinase agit sur eIF3. Cette étude sur les rôles et actions de eIF3 et Paip1 aide à de plus grandes connaissances sur la régulation de l'initiation de la traduction eucaryote.
Chamot, Danuta. "Translation initiation factor 5A (eIF-5A) in plants /." [S.l.] : [s.n.], 1993. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full textReber-Brochocka, Krystyna Barbara. "Charakterisierung genomischer Klone des Proteinsnythese-Initiationsfaktors eIF-4A /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full textEshaque, Bithi. "Characterization of Eukaryotic Translation Initiation Factor 5A isoforms (eIF-5A1 & eIF-5A2) using human cell lines as a model system." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/1218.
Full textThere are two isoforms of eIF-5A in the human genome which have designated eIF-5A1 and eIF-5A2. The objective of the present study was to gain an increased understanding of the roles of eIF-5A1 and eIF-5A2 during apoptosis and cell proliferation using human cell lines as a model system. Apoptosis was induced by treating the cells with Actinomycin D or sodium nitroprusside (SNP), which initiate programmed cell death by different mechanisms. It was observed for both normal and cancer cells that eIF-5A1 protein is up-regulated during apoptosis induced by Actinomycin D or SNP, whereas eIF-5A1 mRNA is constitutively expressed and does not change in abundance during this treatment. The up regulation of eIF-5A1 protein levels in the absence of a corresponding up-regulation in eIF-5A1 mRNA suggests that eIF-5A1 may be post-transcriptionally regulated. Moreover, eIF-5A1 protein up-regulation was stronger in normal cells than in cancer cells. By contrast, eIF-5A2 protein was below detection levels during apoptosis in both normal and cancer cells, although the corresponding transcript was detectable by semi-quantitative RT-PCR. This is attributable to inefficient translation of eIF-5A2 mRNA.
The effects of eIF-5A1 and eIF-5A2 on cell proliferation were examined by modulating the levels of serum in cultures of UACC-1598 cells, which are ovarian cancer cells that express high levels of both isoforms of eIF-5A. Serum starvation, which induces cell cycle arrest and ensuing apoptosis, followed by the re-addition of serum had no effect on the transcript levels of either eIF-5A1 or eIF-5A2. However, eIF-5A1 and eIF-5A2 proteins were both up-regulated within 24 hours of the initiation of serum starvation, and this coincided temporally with the onset of apoptosis as measured by TUNEL and a subsequent decline in viable cells.
The data indicate that eIF-5A1 and eIF-5A2 are both post-transcriptionally regulated and that they have functionally redundant roles in apoptosis.
Books on the topic "Eif6"
Eiff, W. von. Wilhelm von Eiff (1890-1943). Freiburg: Augustinermuseum, 1990.
Find full textSasayama, Haruo. Nihon kodai eifu seido no kenkyū. Tōkyō: Tōkyō Daigaku Shuppankai, 1985.
Find full textCanada Mortgage and Housing Corporation., ed. Exterior insulation and finish systems (EIFS). Ottawa: Canada Mortgage and Housing Corporation, 2004.
Find full textElfed-Owens, Prydwen. Ysgol yr Eifl, Trefor, Caernarfon, Gwynedd LL54 5LU: Inspection under section 10 of the Schools Inspection Act 1996 : school number: 661/2111 : date of inspection: 7-9 October 2002 = Ysgol yr Eifl, Trefor, Caernarfon, Gwynedd LL54 5LU : arolygiad dan adran 10 Deddf Arolygu Ysgolion 1996 : rhif yr ysgol: 661/2111 : dyddiad arolygiad: 7-9 Hydref 2002. [Cardiff]: Estyn, 2002.
Find full textNelson, PE, and RE Kroll, eds. Exterior Insulation Finish Systems (EIFS): Materials, Properties, and Performance. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 1996. http://dx.doi.org/10.1520/stp1269-eb.
Full text1953-, Nelson Peter E., Kroll Richard E. 1942-, American Society for Testing and Materials., and International Symposium on Exterior Insulation and Finish Systems (2nd : 1995 : Denver, Colo.), eds. Exterior insulation finish systems (EIFS): Materials, properties, and performance. West Conshohocken, PA: ASTM, 1996.
Find full textNelson, Peter E., and Bill Egan, eds. Exterior Insulation and Finish Systems (EIFS): Performance, Progress and Innovation. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2016. http://dx.doi.org/10.1520/stp1585-eb.
Full textfinancial systems and corporate performance (Project) European integration. European integration, financial systems and corporate performance (EIFC) working paper. Maastricht, the Netherlands: United Nations University, Institute for New Technologies, 2001.
Find full textEnvironmental Studies Research Funds (Canada), Canada Oil and Gas Lands Administration., and CANATEC Consultants Ltd, eds. Beaufort sea: Ice design criteria : acquisition of data on EIFs. [Ottawa]: Environmental Studies Research Funds, 1992.
Find full textCanada Mortgage and Housing Corporation., ed. Exterior insulation and finish systems (EIFS): Problems, causes and solutions. [Ottawa]: CMHC, 2000.
Find full textBook chapters on the topic "Eif6"
Biffo, Stefano, Daniela Brina, and Stefania Oliveto. "eIF6." In Translation and Its Regulation in Cancer Biology and Medicine, 233–40. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9078-9_11.
Full textBiswas, Arunima, Avik Choudhuri, and Umadas Maitra. "TIF6 (eIF6)." In Encyclopedia of Signaling Molecules, 5437–44. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_615.
Full textGonçalves, João, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, et al. "TIF6 (eIF6)." In Encyclopedia of Signaling Molecules, 1859–66. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_615.
Full textHershey, John W. B. "eIF3." In Translation and Its Regulation in Cancer Biology and Medicine, 173–94. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9078-9_8.
Full textChoudhuri, Avik, Anirban Ray, Arunima Biswas, and Umadas Maitra. "eIF3." In Encyclopedia of Signaling Molecules, 1–10. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-6438-9_101984-1.
Full textMaitra, Umadas, and Romit Majumdar. "TIF5 (eIF5)." In Encyclopedia of Signaling Molecules, 5430–37. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_614.
Full textGonçalves, João, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, et al. "TIF5 (eIF5)." In Encyclopedia of Signaling Molecules, 1853–59. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_614.
Full textNewton, Mark J., and Eric Smith. "EIFS Mesh Coating Improvements." In Exterior Insulation and Finish Systems (EIFS): Performance, Progress and Innovation, 237–47. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2016. http://dx.doi.org/10.1520/stp158520140107.
Full textAktas, Bertal H., and Ting Chen. "The eIF2 Complex and eIF2α." In Translation and Its Regulation in Cancer Biology and Medicine, 195–221. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9078-9_9.
Full textTaylor, A. Judson. "Successful Strategies for EIFS Over-Cladding." In Exterior Insulation and Finish Systems (EIFS): Performance, Progress and Innovation, 88–112. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2016. http://dx.doi.org/10.1520/stp158520140114.
Full textConference papers on the topic "Eif6"
Scagliola, A., A. Miluzio, S. Faienza, S. Oliveto, M. Fedeli, P. Dellabona, C. Voena, R. Chiarle, and S. Biffo. "PO-130 SER235 residue drives eIF6 oncogenic activity in NPM-ALK induced T cell lymphomagenesis." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.171.
Full textMerali, Salim, Oscar Perez-Leal, and Carlos Barrero. "Abstract 4554: Downstream effects of rigosertib (ON 01910.Na) in cancer cells involves impairment of protein translation via eIF2 and eIF4." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4554.
Full textZou, Guang, Kian Banisoleiman, and Arturo González. "Development of Probabilistic Fracture Mechanics Method for Fatigue Life Prediction Based on EIFS Concept." In ASME 2017 36th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/omae2017-61994.
Full textJohnson, W. S., A. C. Wilson, and S. Highsmith. "Equivalent Initial Flaw Size Distribution Determination for Gas Turbine Blades Based Upon Inspection Data." In ASME Turbo Expo 2005: Power for Land, Sea, and Air. ASMEDC, 2005. http://dx.doi.org/10.1115/gt2005-69124.
Full textNewman, James C., and Balkrishna S. Annigeri. "Fatigue-Life Prediction Method Based on Small-Crack Theory in an Engine Material." In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-45644.
Full textChiarelli, Federico, Barbora Kudzmanaite, Giorgio Cacciaguerra Ranghieri, and Miguel Alvarez-Rodriguez. "The EIF monitoring mechanism." In ICEGOV 2020: 13th International Conference on Theory and Practice of Electronic Governance. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3428502.3428627.
Full textZhang, Wei, Huili Liu, Qiang Wang, and Shan Jiang. "Fatigue Life Prediction Using Strain Intensity Factor and Equivalent Initial Flaw Size." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66505.
Full textTuan, Chia-Wei, Ho-Ting Wu, and Mei-Ting Chaung. "A new EIFS strategy for IEEE 802.11e wireless LANs." In the International Conference. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1506270.1506279.
Full textKalogirou, Victoria, Antonis Stasis, and Yannis Charalabidis. "Adapting national interoperability frameworks beyond EIF 3.0." In ICEGOV 2020: 13th International Conference on Theory and Practice of Electronic Governance. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3428502.3428536.
Full textLiu, Yongming, and Sankaran Mahadevan. "An Efficient Method for Equivalent Initial Flaw Size (EIFS) Calculation." In 49th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference
16th AIAA/ASME/AHS Adaptive Structures Conference
10t. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2008. http://dx.doi.org/10.2514/6.2008-1761.
Reports on the topic "Eif6"
Chamovitz, Daniel A., and Albrecht G. Von Arnim. eIF3 Complexes and the eIF3e Subunit in Arabidopsis Development and Translation Initiation. United States Department of Agriculture, September 2009. http://dx.doi.org/10.32747/2009.7696545.bard.
Full textCarbary, Lawrence D., Laura L. Perkins, Roland Serino, Bill Preston, and Jan Kosny. Contributing to Net Zero Building: High Energy Efficient EIFS Wall Systems. Office of Scientific and Technical Information (OSTI), January 2014. http://dx.doi.org/10.2172/1116737.
Full textChamovitz, Daniel, and Albrecht Von Arnim. Translational regulation and light signal transduction in plants: the link between eIF3 and the COP9 signalosome. United States Department of Agriculture, November 2006. http://dx.doi.org/10.32747/2006.7696515.bard.
Full textvon Arnim, Albrecht G. Eukaryotic initiation factor 3 (eIF3) and 5’ mRNA leader sequences as agents of translational regulation in Arabidopsis. Final report. Office of Scientific and Technical Information (OSTI), February 2015. http://dx.doi.org/10.2172/1169186.
Full textMaxwell, J. Integrated Information Support System (IISS). Volume 4. IISS System. Part 6. Enterprise Integration Framework (EIF) for Aerospace. Fort Belvoir, VA: Defense Technical Information Center, September 1990. http://dx.doi.org/10.21236/ada252446.
Full textChamovitz, Daniel, and Xing-Wang Deng. Morphogenesis and Light Signal Transduction in Plants: The p27 Subunit of the COP9-Complex. United States Department of Agriculture, 1997. http://dx.doi.org/10.32747/1997.7580666.bard.
Full textChejanovsky, Nor, and Suzanne M. Thiem. Isolation of Baculoviruses with Expanded Spectrum of Action against Lepidopteran Pests. United States Department of Agriculture, December 2002. http://dx.doi.org/10.32747/2002.7586457.bard.
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