Academic literature on the topic 'Edition génétique'
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Journal articles on the topic "Edition génétique"
Van Hulle, Dirk. "Les Becquets de Beckettvers Vers une édition génétique des dirnières œuvres bilingues." Samuel Beckett Today / Aujourd'hui 17, no. 1 (November 1, 2007): 405–18. http://dx.doi.org/10.1163/18757405-017001028.
Full textBIBE, B., P. MULSANT, and P. SELLIER. "Sommaire et avant-propos." INRAE Productions Animales 13, HS (December 22, 2000): 1–5. http://dx.doi.org/10.20870/productions-animales.2000.13.hs.3804.
Full textHay, Louis. "Rückschau." Editio 33, no. 1 (November 1, 2019): 1–9. http://dx.doi.org/10.1515/editio-2019-0001.
Full textZanardo, Monica. "La critique génétique comme processus (1968–2018). Congrès international du cinquantenaire de l’Institut des textes et manuscrits modernes, Paris, École normale supérieure, Bibliothèque nationale de France, 17.–20. Oktober 2018." Editio 33, no. 1 (November 1, 2019): 159–68. http://dx.doi.org/10.1515/editio-2019-0011.
Full textChaudhry, Ahsen Tahir, and Daud Akhtar. "Gene Therapy and Modification as a Therapeutic Strategy for Cancer." University of Ottawa Journal of Medicine 6, no. 1 (May 11, 2016): 44–48. http://dx.doi.org/10.18192/uojm.v6i1.1564.
Full textAudétat, Marc. "Bovet, Alain: La démocratie et ses gènes. Le génie génétique dans l’espace public suisse (1990–2005). Lausanne, Editions Antipodes, 2013. 159 p. (Collection: contrepied). CHF 29.–. ISBN 978-2-88901-062-2." Gesnerus 71, no. 1 (November 11, 2014): 143–44. http://dx.doi.org/10.1163/22977953-07101006.
Full textNYS, Y. "Préface." INRAE Productions Animales 23, no. 2 (April 10, 2011): 107–10. http://dx.doi.org/10.20870/productions-animales.2010.23.2.3292.
Full textFAVERDIN, P., and C. LEROUX. "Avant-propos." INRAE Productions Animales 26, no. 2 (April 16, 2013): 71–76. http://dx.doi.org/10.20870/productions-animales.2013.26.2.3137.
Full textVauthier, Bénédicte. "‹Crítica textual›? ‹Critique génétique›? ‹Filologia d’autore›?" Editio 26, no. 1 (January 1, 2012). http://dx.doi.org/10.1515/editio-2012-0005.
Full textBoth, Ioana. "Quel avenir pour la critique génétique ?" Acta Août-Septembre 2009 10, no. 7 (September 14, 2009). http://dx.doi.org/10.58282/acta.5154.
Full textDissertations / Theses on the topic "Edition génétique"
Castanon, velasco Oscar. "Targeting the transposable elements of the genome to enable large-scale genome editing and bio-containment technologies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX006.
Full textProgrammable and site-specific nucleases such as CRISPR-Cas9 have started a genome editing revolution, holding hopes to transform human health. Multiplexing or the ability to simultaneously introduce many distinct modifications in the genome will be required for basic and applied research. It will help to probe the physio-pathological functions of complex genetic circuits and to develop improved cell therapies or anti-viral treatments. By pushing the boundaries of genome engineering, we may reach a point where writing whole mammalian genomes will be possible. Such a feat may lead to the generation of virus-, cancer- or aging- free cell lines, universal donor cell therapies or may even open the way to de-extinction. In this doctoral research project, I outline the current state-of-the-art of multiplexed genome editing, the current limits and where such technologies could be headed in the future. We leveraged this knowledge as well as the abundant transposable elements present in our DNA to build an optimization pipeline and develop a new set of tools that enable large-scale genome editing. We achieved a high level of genome modifications up to three orders of magnitude greater than previously recorded, therefore paving the way to mammalian genome writing. In addition, through the observation of the cytotoxicity generated by multiple double-strand breaks within the genome, we developed a bio-safety switch that could potentially prevent the adverse effects of current and future cell therapies. Finally, I lay out the potential concerns and threats that such an advance in genome editing technology may be bringing and point out possible solutions to mitigate the risks
Shirazi, Parsa Hadi. "Engineering of eIF4E gene to resistance against potyviridae viruses in muskmelon using genome editing." Electronic Thesis or Diss., université Paris-Saclay, 2022. http://www.theses.fr/2022UPASB002.
Full textMelon (Cucumis melo L.) is a diploid plant of the Cucurbitaceae family. Since the 17th century, melon has been the object of an active varietal selection using hybridization techniques. In order to accelerate the development of varieties adapted to climatic changes and integrating new characteristics of interest, it is important to adapt to melon, the new methods of selection and genome edition. Melon is a recalcitrant species to genetic transformation. Thus, the development of a protocol for genetic transformation and seedling regeneration is a first step towards the use of the latest genome editing technologies. In the first section of this thesis, different factors affecting the efficiency of the transformation were evaluated. First, we showed that the optimal co-culture time between the explant and the inoculation medium was 20 minutes. The transformation efficiency in an agrobacteria culture at an optical density (OD600) of 0.8 was 11% higher than that of a culture with OD600 of 0.4. In a second step, other factors such as filter paper, concentration of culture medium (10 mM MES) and temperature (24 °C) had a positive effect on the transformation efficiency. The use of filter paper instead of agar to solidify the co-culture medium strongly improved the transformation efficiency. Finally, the effect of ethylene, known to inhibit genetic transformation, was evaluated by adding AVG, AgNO₃ and KMnO₄ to plant tissue culture medium. KMnO₄ was found to be the most effective product increasing the transformation efficiency by more than 50%.Once the transformation and regeneration protocol was set up, the first transgenesis experiments showed a transformation efficiency of 4.72%. 90% of the transformed plants were diploid. In order to develop potyvirus resistant melons, we initiated the editing of target amino acids in the translation initiation factor eIF4E. Targeted genomic editing was performed using the CRIPR-Cas-9 system and guide RNAs designed to target specific amino acids of eIF4E. The analysis of 2500 explants, allowed us to identify 59 transformed lines for an overall efficiency of 2.4 %. After amplification and sequencing of the eIF4E gene in these lines, we identified 17 lines presenting sequence modifications within the eIF4E gene. In T1 lines, nine alleles of eIF4E were identified. Eight alleles were predicted to be deleterious to eIF4E function. These edited lines will be evaluated for their resistance to ZYMV, WMV, CMV, PRSV
Kadner, Maxime. "Développements méthodologiques et applications en biologie translationnelle de techniques d'édition du génome chez le blé tendre." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0029.
Full textA major challenge for agriculture will be its capacity to feed the world in the 21st century in the face of climate change and population growth, while meeting the need for agro-ecological transition. Bread wheat (Triticum aestivum) will be a key issue, and biotechnologies a key tool to be mobilised. Three lines of research involving the CRISPR-Cas tool were addressed in this PhD. First, we evaluated the use of alternative enzymes to Cas9, in particular for their ability to perform multiple mutations simultaneously. We tested the Cas12a enzyme, recognising a different PAM from Cas9 and generating a cohesive cleavage site, as well as the CAS9-NG enzyme, recognising a shorter PAM than Cas9. We obtained very interesting results since we were able to induce up to 16 mutations simultaneously in the same plant, which is particularly encouraging for the future use of this tool in varietal selection programmes. Secondly, we sought to carry out targeted insertion of stop codon cassettes in order to induce more precise gene silencing than is currently possible. Preliminary results obtained by transient expression and analysed by nested PCR have shown that numerous targeted insertion events can be demonstrated, that undesirable degradation events occur preferentially at the ends of the cassette compared to the ends of the genomic DNA generated by the CRISPR-Cas cut, as well as an asymmetry in the occurrence of stochastic DNA insertion events at the ends of the cassette. However, we did not succeed in regenerating a plant with a stable insertion, which implies that a joint improvement of transformation and integration efficiencies will have to be achieved to reach this goal. The results obtained have been the subject of a patent application by the industrial partner, and a publication has been written for submission after the eventual acceptance of the patent. The third axis of our thesis had an applicative vocation of the tools developed in the first two axes on the theme of disease resistance. Indeed, as the agro-ecological transition induces a drastic reduction of synthetic pesticides, a special effort must be made to improve genetic control of diseases, which implies major research efforts to understand plant-pathogen interactions. In this context, in collaboration with the MDC laboratory of the GDEC, we focused on 20 candidate genes for Fusarium head blight (FHB) susceptibility in wheat. The results obtained show that it is possible to extinguish three genes simultaneously, which was previously impossible using conventional mutagenesis techniques. The resulting plant will be phenotyped for its pathogen resistance profile. Taken together, the results of the thesis show that the CRISPR systems are capable of reaching a large number of loci simultaneously in common wheat, and that a targeted insertion of a small DNA fragment is possible but with a very low frequency in stable transformation in the current state of the technology. These results could be applied for the first time to solve the problem of phenotyping QTLs associated with weak effects. They show the need to master and develop these new technologies to answer research questions. These results are also a step towards using editing techniques to support varietal selection, for example by deleting previously identified susceptibility genes in elite varieties. Implications for breeding programmes and possible developments in the light of EU regulatory guidelines are discussed
Soury, Thomas. "Les Fêtes de l'Hymen et de l'Amour de Jean-Philippe Rameau : étude historique, génétique et critique." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR2013/document.
Full textThis thesis focuses on Les Fêtes de l’Hymen et de l’Amour, an heroic ballet written by Jean-Philippe Rameau with a libretto by Louis de Cahusac, created on March 15th, 1747 in Versailles for the Dauphin’s second wedding. The study is about the history of the piece, exploring its various representations, its successive changes and the influence of this opera on the lyric show of the xviiith century. It is also interested in the figure of Louis de Cahusac, his theories on opera and ballet, the inspirations of his libretto drawing Egyptology and Freemasonry. It also addresses the composer’s musical treatment. Lastly, this study offers an edition of the libretto and the score accompanied by a critical apparatus and a catalog’s sources of the opera
Hébert, Sophie Clémentine. "Pour une poétique du carnet dans la littérature française du XXe siècle." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENL018.
Full textOriginally a medium of genesis, both textual and intellectual, an archetypal memory space, the notebook also develops, thanks to the specific writing conditions it favorises, the poetics of attention and regard from which « incident » (Barthes) style and seizure of the moment style emanate directly. The formal discontinuity that these styles create, World writing rather than writings of Self, seems, on the other hand, to encourage the poetics of the anti-journal – perceptible from both the metatextual and formal points of view. Moreover, in the notebook, specific and complex etha unfold, based upon subtle dialectics situated between the « in » and the « out ». Finally, the question of transforming a notebook into a book has to be asked, from the angle of publication as well as in it's reception : which editorial protocol should be priviledged ? What type of reader for a writer's notebook ?
Frésard, Laure. "Recherche de phénomènes singuliers impliqués dans la régulation fine de l'expression du génome chez la poule via l'utilisation de données issues du séquençage haut débit." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2472/.
Full textSince the beginning of domestication crosses have been used in farm animal selection in order to use genetic variability at its best to obtain phenotypes better adapted to our expectations. The main goal is to produce more, ie select animals with good reproduction capacities, growing fast and with good production performances (muscle mass, milk production, egg production. . . ). But another objective is to raise non aggressive and unstressed animals, handling environmental conditions changes without damaging the environment. Most frequently, numerous genes are implicated in phenotypic variability. One big issue is to identify factors causing genetic variability and when possible, to understand the underlying mechanisms, their application being a possible lever to optimize production. Accumulating knowledge on a subject allows defining dogmas, which constitute the bases of our "scientific beliefs". For example, it is known that in a diploid organism, in classical expression conditions, both paternal and maternal transcripts faithfully reproduce coding parts of parental DNA from which they come, in particular concerning genetic variants. However, two exceptions do exist for this rule: parental genomic imprinting and RNA editing. Genomic imprinting is an epigenetic phenomenon leading to a parent-of-origin dependent expression of some genes and the existence of such event in Birds is undergoing a strong debate in literature. RNA editing corresponds to post-transcriptional modifications on RNA without modification of DNA sequence from which it is transcribed. This thesis participates in characterizing these singular phenomena taking part in genome functioning in Chicken, through high-throughput sequencing data analyses. Two chicken lines as inbred and genetically distant as possible were chosen in order to detect numerous polymorphisms and to identify the parental origin of the allele in offspring resulting from their cross. Two reciprocal crosses were made between these lines; genome and transcripts from generated embryos were then sequenced. The analysis of these sequences, which constitutes the major part of this work, allowed us to conclude to the absence of genomic imprinting in Birds, at least in whole embryo at 4. 5 days. These results constitute the first transcriptome-wide approach to seek for genomic imprinting in Chicken. This thesis was also the occasion to characterize RNA editing at genome scale in this species. Results tend to prove that this event is not frequent in comparison to Primates, even if, notably, some edited sites are conserved. Moreover, most modifications correspond to canonical A-to-G substitutions. Finally, we confirm the tissue and stage specificity of this phenomenon
Cullot, Grégoire. "Génotoxicité des systèmes CRISPR-Cas9." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0344.
Full textGene therapy is a promising therapeutic strategy for the monogenic diseases treatment. If the first approaches, called additive, have relied on the use of viral vectors, a growing share is now turning to gene editing. Less than a decade after its characterization, the CRISPR-Cas9 system has moved gene editing to a clinical stage. However, in the same period of time, several questions have been raised regarding the genotoxicity that can be induced by Cas9. An emerging literature points to the risk of genotoxicity at the targeted site. The thesis work presented here is part of this theme. The first part of the study aimed to describe the genotoxicity induced by a single double-stranded break made by Cas9. Characterization of the effects was done both at the nucleotide level, by monitoring the HDR / InDels balance, but also at the chromosome scale. The monitoring of chromosomal integrity has brought to light a new risk of genotoxicity that was not characterized. A sensitive and specific detection system for this risk has been developed to further characterize it. The second objective was to address the limitations of unwanted genotoxicity by developing a safer and more efficient gene editing method through the use of a single single-stranded breakage by Cas9D10A-nickase
Dubruque, Julien. "Edition critique, histoire, genèse et esthétique des deux versions du Temple de la Gloire de Voltaire et Rameau." Thesis, Tours, 2014. http://www.theses.fr/2014TOUR2024/document.
Full textThe court commissioned Voltaire and Rameau to write Le Temple de la Gloire in celebration of the king’s victorious return from Fontenoy. Premiered in Versailles in 1745, restaged in Paris in December, the opera closed down after its critical and box-office failure. It was considerably reworked, restaged in Paris in April 1746, and then forgotten, although many of its pieces were reused in other works. It is the only Voltaire opera staged at the Royal Academy of Music. This study consists of a double critical edition of the libretto and music of the two versions, from 1745 and 1746. It traces the history of the work from 1745 to the present day (Chapter 1), discusses it genetically (Chapter 2), and analyzes its esthetic reach (Chapter 3), which is considerable. Voltaire is not a courtly flatterer here ; he does not present a model of the conquering king, but rather one of a king who makes the people happy. Thus, in 1745, Voltaire extends his dramatic reforms to opera (less love, more entertainment, Metastasian gravitas). But in the end, in 1746, he gives into Rameau, to the Royal Academy of music’s protocol, and to his audience
Bourara, Khaoula. "Mise en évidence d'un processus d'édition des ARNm rétroviraux au cours de l'expression du virus de l'immunodéficience humaine de type 1." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28751.
Full textDahman, Yacine. "Caractérisation de la RNase P nucléaire de Candida glabrata et amélioration des outils d’édition de son génome." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ053/document.
Full textCandida glabrata is an opportunistic pathogenic yeast, and is today the second causative agent of candidemia in Europe and North America. This yeast has many genomic peculiarities such as the presence of new structural domains within ubiquitous non-coding RNAs. The first aspect of this thesis was the study of the atypical RNA subunit of the nuclear Ribonuclease P of C. glabrata. This RNA contains three large additional domains giving the transcript an overall size more than three times larger than the average eukaryotic RNase P RNA subunits. The experiments performed led to a better understanding of the role of these additional domains and demonstrated for the first time the presence of the Rcl1 protein within the RNase P complex. Secondly, this thesis work also contributed to the improvement of existing genome editing tools in C. glabrata. New small and positively selectable integrative cassettes have been developed. These elements exhibited all the required characteristics for their use in wild-type strains and clinical isolates of C. glabrata
Books on the topic "Edition génétique"
author, Cummings Michael R., and Spencer Charlotte author, eds. Essentials of genetics, sixth edition: Yi chuan xue ji chu (di 6 ban). 2nd ed. Beijing Shi: Gao deng jiao yu chu ban she, 2008.
Find full textComment c'est =: How it is ; and / et L'image : a critical-genetic edition = une édition critico-génétique. New York: Routledge, 2001.
Find full textSioud, Mouldy. RNA interference: Challenges and therapeutic opportunities. New York: Humana Press, 2015.
Find full textPractical Genetic Counselling 7th Edition. Taylor & Francis Group, 2017.
Find full textKlug, William S., and Michael R. Cummings. Concepts of Genetics (7th Edition). 7th ed. Prentice Hall, 2002.
Find full textKlug, William S., and Michael R. Cummings. Concepts of Genetics (7th Edition). Prentice Hall, 2002.
Find full textGenetics: From Genes to Genomes, 5th edition. McGraw-Hill Education, 2014.
Find full textNussbaum, Robert L., Roderick R. McInnes, and Huntington F. Willard. Thompson & Thompson Genetics in Medicine, Sixth Edition. 6th ed. W.B. Saunders Company, 2001.
Find full textVoet, Donald, and Judith G. Voet. Biochemistry, 2nd Edition. Wiley, 1996.
Find full textSchaffer, Henry, Thomas G. Gregg, and Lawrence E. Mettler. Population Genetics and Evolution (2nd Edition). Benjamin Cummings, 1998.
Find full textBook chapters on the topic "Edition génétique"
Grésillon, Almuth. "Bemerkungen zur französischen „édition génétique"." In Textgenetische Edition, edited by Hans Zeller and Gunter Martens, 52–64. Berlin, Boston: De Gruyter, 2020. http://dx.doi.org/10.1515/9783110939996-003.
Full textJohansson, Franz, and Richard Walter. "Une édition numérique génétique: Robinson de Paul Valéry." In Textgenese in der digitalen Edition, edited by Anke Bosse and Walter Fanta, 251–64. Berlin, Boston: De Gruyter, 2019. http://dx.doi.org/10.1515/9783110575996-016.
Full textRies, Thorsten. "Das digitale ‚dossier génétique‘. Digitale Materialität, Textgenese und historischkritische Edition." In Textgenese in der digitalen Edition, edited by Anke Bosse and Walter Fanta, 91–116. Berlin, Boston: De Gruyter, 2019. http://dx.doi.org/10.1515/9783110575996-007.
Full textvan Hulle, Dirk. "Comment c’est / How It Is and/et L’image: A Critical-Genetic Edition / Une édition critico-génétique." In Reading Notes, 383–86. BRILL, 2004. http://dx.doi.org/10.1163/9789004483866_034.
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