Relevant bibliographies by topics / Editing genetico germinale

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Editing genetico germinale'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Editing genetico germinale"

1

Sutton, Agneta. "Editing della linea germinale: quali sono i rischi sociali e morali? / Germ-line gene editing: What are the social and moral risks?" Medicina e Morale 65, no. 2 (2016): 123–30. http://dx.doi.org/10.4081/mem.2016.430.

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Dovremmo accogliere tutti i possibili sviluppi dell’editing genetico? L’editing genetico delle cellule somatiche potrebbe essere considerato alla pari delle terapie convenzionali volte a trattare particolari patologie o ad alleviarne i sintomi. Tale intervento interesserebbe esclusivamente il singolo paziente trattato. Esso potrebbe quindi essere ben accolto come un nuovo tipo di trattamento per i tumori e le malattie del sangue, come ad esempio la beta-talassemia. Diversamente, l’editing della linea germinale avrebbe effetti ereditari. Ciò solleva preoccupazioni particolari riguardo al rischi
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Iqbal, Gowhar, Nahida Quyoom, Lukram Sushil Singh, et al. "Genome Editing Technology in Fishes." Current Journal of Applied Science and Technology 42, no. 23 (2023): 20–26. http://dx.doi.org/10.9734/cjast/2023/v42i234170.

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Genome editing and silencing techniques can transform the biology that we understand, diseases affecting fish and other aquatic animals. Gene editing is now being tested in aquaculture, reproduction control, sterility, and disease resistance aspects. More money must be invested in innovative technology to solve these issues in this industry. So gene silencing and genomic DNA editing have the potential significant impact on aquatic animal treatment in the future. Genome editing in fish is an interested part of research that has the potential to revolutionize aquaculture and aid in the understan
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3

Ben Shlush, Ilan Ben, Aviva Samach, Cathy Melamed-Bessudo, et al. "CRISPR/Cas9 Induced Somatic Recombination at the CRTISO Locus in Tomato." Genes 12, no. 1 (2020): 59. http://dx.doi.org/10.3390/genes12010059.

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Homologous recombination (HR) in somatic cells is not as well understood as meiotic recombination and is thought to be rare. In a previous study, we showed that Inter-Homologous Somatic Recombination (IHSR) can be achieved by targeted induction of DNA double-strand breaks (DSBs). Here, we designed a novel IHSR assay to investigate this phenomenon in greater depth. We utilized F1 hybrids from divergent parental lines, each with a different mutation at the Carotenoid isomerase (CRTISO) locus. IHSR events, namely crossover or gene conversion (GC), between the two CRTISO mutant alleles (tangerine
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Henderson, Sam W., Steven T. Henderson, Marc Goetz, and Anna M. G. Koltunow. "Efficient CRISPR/Cas9-Mediated Knockout of an Endogenous PHYTOENE DESATURASE Gene in T1 Progeny of Apomictic Hieracium Enables New Strategies for Apomixis Gene Identification." Genes 11, no. 9 (2020): 1064. http://dx.doi.org/10.3390/genes11091064.

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Most Hieracium subgenus Pilosella species are self-incompatible. Some undergo facultative apomixis where most seeds form asexually with a maternal genotype. Most embryo sacs develop by mitosis, without meiosis and seeds form without fertilization. Apomixis is controlled by dominant loci where recombination is suppressed. Loci deletion by γ-irradiation results in reversion to sexual reproduction. Targeted mutagenesis of genes at identified loci would facilitate causal gene identification. In this study, the efficacy of CRISPR/Cas9 editing was examined in apomictic Hieracium by targeting mutatio
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Barberini, Sara, Chiara Forti, Marina Laura, et al. "An Optimized Protocol for In Vitro Regeneration of Ocimum basilicum cv. FT Italiko." Horticulturae 9, no. 3 (2023): 407. http://dx.doi.org/10.3390/horticulturae9030407.

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Sweet basil (Ocimum basilicum L.; Fam. Lamiaceae) is an annual herbaceous plant with a high economic value used in folk medicine, pharmacology, and food production. In Italy, most of the varieties are used to produce the famous “pesto” sauce; however, almost all of them are susceptible to basil downy mildew (BDM) disease, strongly decreasing the growth of the fresh leaves and the survival of the whole plant. Nowadays, CRISPR/Cas9 technology is recognized to be a prominent way to enhance basil genetic breeding. In this work, we present an optimized protocol for in vitro direct regeneration of a
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Hoang, Doan, and Simon Hoang. "Deep learning - cancer genetics and application of deep learning to cancer oncology." Vietnam Journal of Science and Technology 60, no. 6 (2022): 885–928. http://dx.doi.org/10.15625/2525-2518/17256.

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Arguably the human body has been one of the most sophisticated systems we encounter but until now we are still far from understanding its complexity. We have been trying to replicate human intelligence by way of artificial intelligence but with limited success. We have discovered the molecular structure in terms of genetics, performed gene editing to change an organism’s DNA and much more, but their translatability into the field of oncology has remained limited. Conventional machine learning methods achieved some degree of success in solving problems that we do not have an explicit algorithm.
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7

Pasqualucci, Laura, Mara Compagno, Tongwei Mo, et al. "Activation Induced Cytidine Deaminase (AID) Is Required for Germinal-Center Derived Lymphomagenesis." Blood 108, no. 11 (2006): 223. http://dx.doi.org/10.1182/blood.v108.11.223.223.

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Abstract Most B cell non-Hodgkin’s lymphomas (B-NHL) derive from germinal center (GC) B cells and their pathogenesis is associated with the accumulation of distinct genetic lesions, including chromosomal translocations and a more recently identified mechanism of genomic instability, termed aberrant somatic hypermutation. These alterations are thought to be due to mistakes occurring during two GC-associated immunoglobulin (Ig) genes remodeling processes: class switch recombination (CSR) and somatic hypermutation (SHM). However, this model has never been formally proven. To conclusively investig
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8

Patel, Amit K., Risa M. Broyer, Cassidy D. Lee, et al. "Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons." Proceedings of the National Academy of Sciences 117, no. 52 (2020): 33597–607. http://dx.doi.org/10.1073/pnas.2004683117.

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Axon injury is a hallmark of many neurodegenerative diseases, often resulting in neuronal cell death and functional impairment. Dual leucine zipper kinase (DLK) has emerged as a key mediator of this process. However, while DLK inhibition is robustly protective in a wide range of neurodegenerative disease models, it also inhibits axonal regeneration. Indeed, there are no genetic perturbations that are known to both improve long-term survival and promote regeneration. To identify such a neuroprotective target, we conducted a set of complementary high-throughput screens using a protein kinase inh
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Ross, Aisling M., Ciara I. Leahy, Fiona Neylon, et al. "Epstein–Barr Virus and the Pathogenesis of Diffuse Large B-Cell Lymphoma." Life 13, no. 2 (2023): 521. http://dx.doi.org/10.3390/life13020521.

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Epstein–Barr virus (EBV), defined as a group I carcinogen by the World Health Organization (WHO), is present in the tumour cells of patients with different forms of B-cell lymphoma, including Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and, most recently, diffuse large B-cell lymphoma (DLBCL). Understanding how EBV contributes to the development of these different types of B-cell lymphoma has not only provided fundamental insights into the underlying mechanisms of viral oncogenesis, but has also highlighted potential new therapeutic opportunities. In this
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Ten Hacken, Elisa, Shanye Yin, Kendell Clement, et al. "Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations." Blood 134, Supplement_1 (2019): 684. http://dx.doi.org/10.1182/blood-2019-127673.

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Mouse models represent invaluable tools for the systematic evaluation of cancer drivers, yet models that address the impact of putative genetic drivers of chronic lymphocytic leukemia (CLL) on B cell development and function are largely lacking. To study recurrent loss-of-function (LOF) mutations observed in human CLL, we established a transplant model that can rapidly evaluate genetic lesions. First, we crossed mice carrying B-cell restricted Cre expression (Cd19-cre) with mice carrying conditional Cas9-GFP, to generate a strain expressing B cell-restricted Cas9 (Cd19-Cas9). Next, we optimize
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Dissertations / Theses on the topic "Editing genetico germinale"

1

BONOMELLI, SARA. "L'EDITING GENETICO GERMINALE UMANO, TRA PROBLEMI ETICI E QUESTIONI DI GOVERNANCE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/922688.

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The dissertation aims at identifying and analyzing the scientific, legal, and ethical issues raised by the perspective of intentional modification of human germline by the potential future use of gene editing techniques in the context of human reproduction. Such a study makes it possible to formulate some critical considerations about human germline gene editing governance. The dissertation claims that the best option to regulate the use of this biotechnological innovation for reproductive purposes consists of a regulation on a state-by-state-basis, which should however be developed within a
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INSANGUINE, MINGARRO Ferdinando Achille. "MODIFICAZIONI GERMINALI DEL PATRIMONIO GENETICO E BIODIRITTO. I paradossi della de-differenziazione tra bioetica e biodiritto." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/507066.

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Il presente lavoro, incominciato nel novembre del 2017, è partito con l'ambizione di ricostruire la risposta che il sistema giuridico fornisce innanzi alle nuove tecniche di ingegneria genetica che, a fronte della loro applicabilità sugli esseri umani, hanno prodotto, negli ultimi anni, il sorgere di nuovi stakeholders e, ancor prima, di nuovi interessi meritevoli di tutela. Se fino a qualche anno fa pareva impensabile modificare il genoma umano e, men che meno, farlo in maniera precisa, efficiente ed economica, oggi grazie al sistema di modificazione genetica CRISPR/Cas9 è possibile, interv
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INSANGUINE, MINGARRO Ferdinando Achille. "Modificazioni germinali del patrimonio genetico e biodiritto. I paradossi della de-differenziazione tra bioetica e biodiritto." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/499144.

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Il presente lavoro, incominciato nel novembre del 2017, è partito con l'ambizione di ricostruire la risposta che il sistema giuridico fornisce innanzi alle nuove tecniche di ingegneria genetica che, a fronte della loro applicabilità sugli esseri umani, hanno prodotto, negli ultimi anni, il sorgere di nuovi stakeholders e, ancor prima, di nuovi interessi meritevoli di tutela. Se fino a qualche anno fa pareva impensabile modificare il genoma umano e, men che meno, farlo in maniera precisa, efficiente ed economica, oggi grazie al sistema di modificazione genetica CRISPR/Cas9 è possibile, interv
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4

Botas, Bruna Patrícia Marques. "Edição Genética em Embriões Humanos - A Responsabilidade Civil Médica No Contexto da Terapia Génica Germinal." Master's thesis, 2021. http://hdl.handle.net/10316/97516.

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Dissertação de Mestrado em Direito apresentada à Faculdade de Direito<br>O mundo tem vindo a assistir grandes desenvolvimentos no domínio da genética e medicina reprodutiva, passando-se a falar da “Revolução GNR (Genética, Nanotecnologia e Robótica)”, capaz de promover a saúde e qualidade de vida humana, como nunca antes. O avanço que maior destaque tem tido na comunidade científica e que será aqui objeto de estudo, insere-se no contexto da Engenharia genética, com o surgimento da tecnologia CRISPR/Cas com potencialidade de corrigir, substituir e modificar o genoma humano, de forma rápida e pr
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