Journal articles on the topic 'Editing and toning period'
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Povar, Anna. "EDITING IN THE PERIOD OF MANUSCRIPT BOOK." Integrated communications, no. 3 (2017): 89–91. http://dx.doi.org/10.28925/2524-2644.2017.3.18.
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The article examines the role of manuscript editing in the process of editing formation and definition of editor’s functions. The analysis of manuscript artifacts is conducted and the purpose of intervention of editor (compiler, interpreter, copywriter) of the text is represented. The research was carried out within the framework of the discipline “Fundamentals of Editorial Skills” (the lecturer –Vernyhora N. M., Associate Professor of Publishing Department).
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Yamaguchi, Kumiko, Fuminori Yamaguchi, Osamu Miyamoto, Osamu Hatase, and Masaaki Tokuda. "The Reversible Change of GluR2 RNA Editing in Gerbil Hippocampus in Course of Ischemic Tolerance." Journal of Cerebral Blood Flow & Metabolism 19, no. 4 (April 1999): 370–75. http://dx.doi.org/10.1097/00004647-199904000-00002.
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The ischemic tolerance is known to show protective effects on the neurons and the restricted Ca2+ influx through Ca2+ channels might be involved. In α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, ribonucleic acid (RNA) editing of the GluR2 subunit determines receptor desensitization and Ca2+ permeability. The authors investigated the effect of ischemic tolerance on the messenger RNA editing of Q/R and R/G sites of GluR2 subunit in hippocampus. It was found that the rate of RNA editing in Q/R site showed no change (100% edited), whereas that in R/G site decreased significantly (83.3% normal editing level to 60.4%) at day 3 (preconditioning period) and returned to normal level at day 14 (after preconditioning period). Further investigation revealed that the decrease of editing rate in ischemic tolerance resulted mainly from the decrease of editing in CA1 area.
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Wu, Xiaoyun, Wondossen Ayalew, Min Chu, Jie Pei, Chunnian Liang, Pengjia Bao, Xian Guo, and Ping Yan. "Characterization of RNA Editome in the Mammary Gland of Yaks during the Lactation and Dry Periods." Animals 12, no. 2 (January 16, 2022): 207. http://dx.doi.org/10.3390/ani12020207.
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The mammary gland is a complicated organ comprising several types of cells, and it undergoes extensive morphogenetic and metabolic changes during the female reproductive cycle. RNA editing is a posttranscriptional modification event occurring at the RNA nucleotide level, and it drives transcriptomic and proteomic diversities, with potential functional consequences. RNA editing in the mammary gland of yaks, however, remains poorly understood. Here, we used REDItools to identify RNA editing sites in mammary gland tissues in yaks during the lactation period (LP, n = 2) and dry period (DP, n = 3). Totally, 82,872 unique RNA editing sites were identified, most of which were detected in the noncoding regions with a low editing degree. In the coding regions (CDS), we detected 5235 editing sites, among which 1884 caused nonsynonymous amino acid changes. Of these RNA editing sites, 486 were found to generate novel possible miRNA target sites or interfere with the initial miRNA binding sites, indicating that RNA editing was related to gene regulation mediated by miRNA. A total of 14,159 RNA editing sites (involving 3238 common genes) showed a significant differential editing level in the LP when compared with that in the DP through Tukey’s Honest Significant Difference method (p < 0.05). According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, genes that showed different RNA editing levels mainly participated in pathways highly related to mammary gland development, including MAPK, PI3K-Akt, FoxO, and GnRH signaling pathways. Collectively, this work demonstrated for the first time the dynamic RNA editome profiles in the mammary gland of yaks and shed more light on the mechanism that regulates lactation together with mammary gland development.
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Cho, Seong-woon. "Publishing and editing of textbooks on national history in Syllabus Period." Journal of Studies on Korean National Movement 86 (March 30, 2016): 279–324. http://dx.doi.org/10.19162/knm.86.2016.3.08.
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Gibney, Frank B. "Editing Japanese Letters to the Asahi Shimbun." Journal of American-East Asian Relations 11, no. 1-2 (2002): 165–67. http://dx.doi.org/10.1163/187656102793645415.
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AbstractEvery nation, every society has its share of historical memories. They include, most obviously, the experiences of people who lived through past events, as they recall them. Then there is the record, written down in textbooks or literary works transmitted to generations who came after these events, but relived them vicariously, trusting in the accuracy of their national historians. Often historical records are magnified—or smudged out—by popular myths. In some cases, whether because of wars, revolutions, or other political upheavals, the records for a period of history are defective or totally missing from the national memory.
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Widén, Per. "Creating a Patrotic History: Historical Source-Editing as National Monument." Romantik: Journal for the Study of Romanticisms 5, no. 1 (December 1, 2016): 9. http://dx.doi.org/10.7146/rom.v5i1.26425.
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‘Kungliga samfundet för utgivande av handskrifter rörande Skandinaviens historia’ [Royal society for the publication of manuscripts on Scandinavian history], a society dedicated to the editing and printing of historical source documents, was founded in Stockholm in 1815. Earlier research has focused upon the editorial praxis of the society’s publication, Handlingar rörande Skandinaviens historia. Here I focus more upon the monumental and museological aspects of the society’s work. Viewed as types of national monument, source editions from the romantic era can tell us something about how history was produced and popularised during this period. The source documents printed in Handlingar served as educational tools intended to help the reader better understand history, specifically in this case the history of Sweden. But such editions also functioned – like a museum or a monument – as triggers for emotions, memory, and historicity, and like those other institutions, romantic-period source editions played a significant role in the construction and negotiation of national memory and heritage.
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Samuel, Charles E. "Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses." Journal of Biological Chemistry 294, no. 5 (February 1, 2019): 1710–20. http://dx.doi.org/10.1074/jbc.tm118.004166.
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Herbert “Herb” Tabor, who celebrated his 100th birthday this past year, served the Journal of Biological Chemistry as a member of the Editorial Board beginning in 1961, as an Associate Editor, and as Editor-in-Chief for 40 years, from 1971 until 2010. Among the many discoveries in biological chemistry during this period was the identification of RNA modification by C6 deamination of adenosine (A) to produce inosine (I) in double-stranded (ds) RNA. This posttranscriptional RNA modification by adenosine deamination, known as A-to-I RNA editing, diversifies the transcriptome and modulates the innate immune interferon response. A-to-I editing is catalyzed by a family of enzymes, adenosine deaminases acting on dsRNA (ADARs). The roles of A-to-I editing are varied and include effects on mRNA translation, pre-mRNA splicing, and micro-RNA silencing. Suppression of dsRNA-triggered induction and action of interferon, the cornerstone of innate immunity, has emerged as a key function of ADAR1 editing of self (cellular) and nonself (viral) dsRNAs. A-to-I modification of RNA is essential for the normal regulation of cellular processes. Dysregulation of A-to-I editing by ADAR1 can have profound consequences, ranging from effects on cell growth and development to autoimmune disorders.
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Korotkova, A. M., S. V. Gerasimova, and E. K. Khlestkina. "Current achievements in modifying crop genes using CRISPR/Cas system." Vavilov Journal of Genetics and Breeding 23, no. 1 (February 26, 2019): 29–37. http://dx.doi.org/10.18699/vj19.458.
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With the advent of the new genome editing tool of target-specifically customizable endonucleases, a huge variety of novel opportunities have become feasible. The crop improvement is one of the main applications of genome editing in plant science and plant biotechnology. The amount of publications referring to genome editing and CRISPR/Cas system based molecular tools application in crops is permanently growing. The aim of this study is the systematization and cataloging of these data. Earlier we published the first catalog of targeted crop genome modifications as of February 10, 2017. The current review is an update of the catalog; it covers research papers on crop genome modifications from February 10, 2017 to August 17, 2018, found by searching 47 crop names in the Scopus database. Over one year and a half, 377 articles mentioning CRISPR/Cas and crop names have been published, of which 131 articles describe an experimental application of this tool for editing 193 genes in 19 crops, including rice with the largest number of genes modified (109 genes). Editing 50 of 193 genes was aimed at crop improvement. The catalog presented here includes these 50 genes, specifying the cultivars, each gene and gene product function, modification type and delivery method used. The current full list of genes modified with CRISPR/Cas with the aim of crop improvement is 81 in 16 crops (for 5 years from August 2013 to August 2018). In this paper, we also summarize data on different modifications types in different crops and provide a brief review of some novel methods and approaches that have appeared in crop genome editing research over the reviewed period. Taken together, these data provide a clear view on current progress in crop genome modifications and traits improvement using CRISPR/Cas based genome editing technology.
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Baci, Gabriela-Maria, Alexandra-Antonia Cucu, Alexandru-Ioan Giurgiu, Adriana-Sebastiana Muscă, Lilla Bagameri, Adela Ramona Moise, Otilia Bobiș, Attila Cristian Rațiu, and Daniel Severus Dezmirean. "Advances in Editing Silkworms (Bombyx mori) Genome by Using the CRISPR-Cas System." Insects 13, no. 1 (December 27, 2021): 28. http://dx.doi.org/10.3390/insects13010028.
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CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) represents a powerful genome editing technology that revolutionized in a short period of time numerous natural sciences branches. Therefore, extraordinary progress was made in various fields, such as entomology or biotechnology. Bombyx mori is one of the most important insects, not only for the sericulture industry, but for numerous scientific areas. The silkworms play a key role as a model organism, but also as a bioreactor for the recombinant protein production. Nowadays, the CRISPR-Cas genome editing system is frequently used in order to perform gene analyses, to increase the resistance against certain pathogens or as an imaging tool in B. mori. Here, we provide an overview of various studies that made use of CRISPR-Cas for B. mori genome editing, with a focus on emphasizing the high applicability of this system in entomology and biological sciences.
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田, 昕蕊. "The Editing Thought and Writing Style of Lantian County Records of the Guangxu Period." Advances in Social Sciences 10, no. 07 (2021): 1655–65. http://dx.doi.org/10.12677/ass.2021.107229.
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Seok, Heeyoung, Rui Deng, Douglas B. Cowan, and Da-Zhi Wang. "Application of CRISPR-Cas9 gene editing for congenital heart disease." Clinical and Experimental Pediatrics 64, no. 6 (June 15, 2021): 269–79. http://dx.doi.org/10.3345/cep.2020.02096.
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Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) is an ancient prokaryotic defense system that precisely cuts foreign genomic DNA under the control of a small number of guide RNAs. The CRISPR-Cas9 system facilitates efficient double-stranded DNA cleavage that has been recently adopted for genome editing to create or correct inherited genetic mutations causing disease. Congenital heart disease (CHD) is generally caused by genetic mutations such as base substitutions, deletions, and insertions, which result in diverse developmental defects and remains a leading cause of birth defects. Pediatric CHD patients exhibit a spectrum of cardiac abnormalities such as septal defects, valvular defects, and abnormal chamber development. CHD onset occurs during the prenatal period and often results in early lethality during childhood. Because CRISPR-Cas9-based genome editing technology has gained considerable attention for its potential to prevent and treat diseases, we will review the CRISPR-Cas9 system as a genome editing tool and focus on its therapeutic application for CHD.
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Assael, Davide. "Il neotrascendentalismo di Giovanni Emanuele Barié." RIVISTA DI STORIA DELLA FILOSOFIA, no. 4 (December 2009): 731–58. http://dx.doi.org/10.3280/sf2009-004003.
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- Giovanni Emanuele Barié, appointed Professor of Theoretical Philosophy at Milan University in 1937, is one of the most neglected figures in Italian philosophy of the last century. An exponent of late Italian idealism, it could be argued that only through his work, alongside that of others like Bernardino Varisco, Pantaleo Carabellese and Vito Fazio Allmayer, was Italian idealism able to reach full theoretical maturity. Born in Milan in 1894, before going to university, Barié displayed great courage on the battlefield during the first world war. On his return, he first studied Law and then took a second degree in Philosophy under Piero Martinetti. In 1933, his La spiritualitŕ dell'essere e Leibniz enabled him to obtain a university teaching post, first in Genoa, later in Rome and, finally, in Milan in the chair previously occupied by his mentor. The first period of Barié's work is characterized by a re-evaluation of the Kantian a priori against the reductionist perspective of contemporary thought. Books like La posizione gnoseologica della matematica (1925) and Oltre la Critica (1929) belong to this stage in his life. From 1933, Barié started on an interpretation of Hegel with the intention of toning down the transcendental aspects of Kant's and Martinetti's thought. His most important writings from this period are L'io trascendentale (1948) and his last work Il concetto trascendentale (1957), which came out in the same year the philosopher committed suicide.
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Sheridan, Dorothy. "Woven Tapestries: Dialogues and Dilemmas in Editing a Diary." European Journal of Life Writing 10 (April 22, 2021): MO45—MO67. http://dx.doi.org/10.21827/ejlw.10.37405.
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Naomi Mitchison (1897-1999) was an established novelist and political campaigner throughout her life. During the Second World War, she kept an extensive daily diary from her home on the Mull of Kintyre in Scotland which she sent in instalments to the London offices of the social research organisation, Mass Observation. Until the 1980s, this diary, together with 500 other diaries for the same period, remained largely unread. It was stored as part of the valuable Mass Observation Archive which was deposited at the University of Sussex in 1970. Between 1982 and 1984 it was edited for publication by Dorothy Sheridan, the Mass Observation archivist, in collaboration with Naomi Mitchison herself. It was first published as a book in 1985 by Gollancz as Among you taking notes: the wartime diary of Naomi Mitchison 1939-1945. This article is an account of the collaborative process of editing the original diary for publication and addresses questions of ownership, ethics and methodology raised by the process of editing life documents.
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Chang, Shin-Shin, and Jung-Hua Chang. "People's Preference Patterns for Gains/Losses in Multiple Time Period Situations." Psychological Reports 113, no. 2 (October 2013): 635–46. http://dx.doi.org/10.2466/17.14.pr0.113x21z5.
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Little research to date has been devoted to investigating whether people treat time differently from money when facing multiple gains or losses. This study tested the hypothesis that because time is characterized by perishability, fixed supply, and infungibility, people with strong motivation to obtain a long period of uninterrupted discretionary time would strive to trim the time needed for non-discretionary activities or to combine several non-discretionary activities. As a result, people prefer integration over segregation of multiple time losses or gains, which is not consistent with the prediction based on hedonic editing theory or the renewable resource model. This proposition is supported by results from four experiments.
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Marincin, Kenneth A., Indrani Pal, and Dominique P. Frueh. "Using delayed decoupling to attenuate residual signals in editing filters." Magnetic Resonance 2, no. 1 (June 21, 2021): 475–87. http://dx.doi.org/10.5194/mr-2-475-2021.
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Abstract. Isotope filtering methods are instrumental in biomolecular nuclear magnetic resonance (NMR) studies as they isolate signals of chemical moieties of interest within complex molecular assemblies. However, isotope filters suppress undesired signals of isotopically enriched molecules through scalar couplings, and variations in scalar couplings lead to imperfect suppressions, as occurs for aliphatic and aromatic moieties in proteins. Here, we show that signals that have escaped traditional filters can be attenuated with mitigated sensitivity losses for the desired signals of unlabeled moieties. The method uses a shared evolution between the detection and preceding preparation period to establish non-observable antiphase coherences and eliminates them through composite pulse decoupling. We demonstrate the method by isolating signals of an unlabeled post-translational modification tethered to an isotopically enriched protein.
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Shiroshita, Kohei, Hiroshi Kobayashi, Shinichiro Okamoto, Keisuke Kataoka, and Keiyo Takubo. "Reverting to Quiescence Preserves Hematopoietic Stem Cells Following Genome Editing." Blood 138, Supplement 1 (November 5, 2021): 3977. http://dx.doi.org/10.1182/blood-2021-149520.
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Abstract Hematopoietic stem cells (HSCs) in steady-state are quiescent in cell cycle. CRISPR-Cas9 genome editing has revolutionized the HSC research and therapeutic application of HSCs for hematological diseases. Although these methods and clinical results are promising, keeping HSC function after highly efficient genome editing is still challenging because HSCs gradually lose their repopulation capacity following cell cycle activation. Preserving the function of HSCs after genome editing is an urgent issue. In this study, we interrogated the culture method following genome editing to reverse the cell cycle status of HSCs into a quiescent state to test how cell cycle status affects the genome editing efficiency and the HSC potential. To assess the relationship between genome editing efficiency and cell cycle status, we compared genome editing efficiency among the freshly-isolated or cultured HSCs and progenitors (HSPCs) at various time points. Ribonucleoprotein (RNP) complex was delivered into cells by electroporation. Genome-editing efficiency was evaluated by CD45 knockout rate comparing sgRNA for Rosa and CD45. All the HSPC fractions cultured displayed higher genome-editing efficiency following over-night preculture. Genome-editing efficiency of fresh HSC was lower than 20% while fresh granulocyte/monocyte progenitor (GMP) showed higher than 40%. Cell cycle analysis using EdU or Ki67 and Hoechst 33342 staining confirmed that genome-editing efficiency positively correlated with cell cycle activation. We further tested the effect of pre- and post-culture conditions for genome editing. While preculture with high cytokine concentration for a long period of time (> 16 hours) is required for the efficient genome editing, post-culture condition did not compromise the genome-editing efficiency. Given the quiescent nature of HSCs, we hypothesized that reverting activated HSCs back to quiescent state may improve the function of HSCs following genome editing. To test this, genome-edited HSCs were cultured in the quiescence-maintaining condition (SCF 1.5 ng/mL and TPO 1.0 ng/mL) under 1% O 2 atmosphere. After 7-day culture, more than 30% of cells kept the surface marker phenotype of CD150 + CD48 - LSK, and over 60% of cells were successfully underwent genome editing. Less than 10% of HSCs were EdU +, suggesting that HSCs reverted to cell cycle quiescence after genome editing. By contrast, HSCs cultured in a conventional high cytokine condition (proliferative condition) lost the surface marker phenotypes and highly incorporated EdU. To assess the long-term reconstitution potential of edited HSCs, the Evi1 expression level was evaluated using Evi1-IRES-GFP mice. The expression level of Evi1 was significantly higher in quiescent HSCs than proliferating HSCs after editing. These results suggest that, as post-electroporation culture, quiescence-maintaining condition reverts precultured HSCs back to a quiescent state in cell cycle. This protocol maintains phenotypic HSCs without compromising the genome-editing efficiency. To further determine the function of genome-edited HSCs, single cell colony assay was performed. Clonally sorted CD45 knockout HSCs cultured in the quiescence-maintaining condition after gene editing fully maintained colony-forming capacity, but HSCs cultured in the proliferating condition lost their capacity. We then performed transplantation assays using Ubc-GFP mice. GFP + HSCs were genome-edited for Rosa and transplanted into lethally-irradiated recipient mice with competitor cells. The donor-derived chimerism of edited HSCs with quiescence-maintaining condition in peripheral blood and bone marrow was generally superior to that of edited HSCs with proliferative condition. These data demonstrates that edited HSCs cultured in quiescence-maintaining condition maintain stem cell potential in vitro and in vivo. Altogether, we established an HSC-optimized, highly efficient genome-editing protocol. This study demonstrated that effectiveness of keeping HSC in a quiescent state even in the setting of genome editing. Our protocol is suitable for unveiling the function of genes distinguishing cycling and quiescent HSCs. Disclosures Kataoka: Celgene: Honoraria; Eisai: Honoraria; Astellas Pharma: Honoraria; Novartis: Honoraria; Chugai Pharmaceutical: Honoraria; AstraZeneca: Honoraria; Sumitomo Dainippon Pharma: Honoraria; Kyowa Kirin: Honoraria; Janssen Pharmaceutical: Honoraria; MSD: Honoraria; Takeda Pharmaceutical: Honoraria; Otsuka Pharmaceutical: Honoraria; Asahi Genomics: Current equity holder in publicly-traded company; Otsuka Pharmaceutical: Research Funding; Chordia Therapeutics: Research Funding; Chugai Pharmaceutical: Research Funding; Takeda Pharmaceutical: Research Funding; Bristol-Myers Squibb: Research Funding; Eisai: Other: Scholarship; Otsuka Pharmaceutical: Other: Scholarship; Ono Pharmaceutical: Other: Scholarship; Kyowa Kirin: Other: Scholarship; Shionogi: Other: Scholarship; Takeda Pharmaceutical: Other: Scholarship; Summitomo Dainippon Pharma: Other: Scholarship; Chugai Pharmaceutical: Other: Scholarship; Teijn Pharma: Other: Scholarship; Japan Blood Products Organization: Other: Scholarship; Mochida Pharmaceutical: Other: Scholarship; JCR Pharmaceuticals: Other: Scholarship; Genetic Alterations: Patents & Royalties: PD-L1 abnormalties .
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Schneider, Edgar W. "Editor’s report 2003–2007." English World-Wide 28, no. 3 (October 30, 2007): 349–55. http://dx.doi.org/10.1075/eww.28.3.12sch.
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This article provides a report from the editorial office of English World-Wide, covering the five-year period of 2003 to 2007. Specifically, it describes the stages of the editing and manuscript handling process from submission to publication, and it breaks down submission and publication figures of articles by world regions.
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Xu, Xin, Yujin Yuan, Bihong Feng, and Wei Deng. "CRISPR/Cas9-mediated gene-editing technology in fruit quality improvement." Food Quality and Safety 4, no. 4 (October 27, 2020): 159–66. http://dx.doi.org/10.1093/fqsafe/fyaa028.
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Abstract Fruits are an essential part of a healthy, balanced diet and it is particularly important for fibre, essential vitamins, and trace elements. Improvement in the quality of fruit and elongation of shelf life are crucial goals for researchers. However, traditional techniques have some drawbacks, such as long period, low efficiency, and difficulty in the modification of target genes, which limit the progress of the study. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technique was developed and has become the most popular gene-editing technology with high efficiency, simplicity, and low cost. CRISPR/Cas9 technique is widely accepted to analyse gene function and complete genetic modification. This review introduces the latest progress of CRISPR/Cas9 technology in fruit quality improvement. For example, CRISPR/Cas9-mediated targeted mutagenesis of RIPENING INHIBITOR gene (RIN), Lycopene desaturase (PDS), Pectate lyases (PL), SlMYB12, and CLAVATA3 (CLV3) can affect fruit ripening, fruit bioactive compounds, fruit texture, fruit colouration, and fruit size. CRISPR/Cas9-mediated mutagenesis has become an efficient method to modify target genes and improve fruit quality.
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Liu, Qier, Fan Yang, Jingjuan Zhang, Hang Liu, Shanjida Rahman, Shahidul Islam, Wujun Ma, and Maoyun She. "Application of CRISPR/Cas9 in Crop Quality Improvement." International Journal of Molecular Sciences 22, no. 8 (April 19, 2021): 4206. http://dx.doi.org/10.3390/ijms22084206.
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The various crop species are major agricultural products and play an indispensable role in sustaining human life. Over a long period, breeders strove to increase crop yield and improve quality through traditional breeding strategies. Today, many breeders have achieved remarkable results using modern molecular technologies. Recently, a new gene-editing system, named the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology, has also succeeded in improving crop quality. It has become the most popular tool for crop improvement due to its versatility. It has accelerated crop breeding progress by virtue of its precision in specific gene editing. This review summarizes the current application of CRISPR/Cas9 technology in crop quality improvement. It includes the modulation in appearance, palatability, nutritional components and other preferred traits of various crops. In addition, the challenge in its future application is also discussed.
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Aisyah, Alfiyani. "Jogjaprov.go.id Website Management in Realizing Good Governance of the Special Government of Yogyakarta Period 2019." Journal of Islamic Communication and Counseling 1, no. 1 (January 10, 2022): 41–55. http://dx.doi.org/10.18196/jicc.v1i1.8.
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Disclosure of information becomes an important part of governance to create good governance or good governance. One of the efforts of the DIY regional government to realize good governance is through transparent information disclosure. The website jogjaprov.go.id managed by the public relations government of DIY never got the most innovative service website in the year 2019 and the first ranking award of Best smart Governance. Public relations of DIY regional government use the website as one of the information media to implement e-government so that people can access and know the information quickly. As for the management of the website, the public relations of DIY regional Government conducted several stages as follows: searching and collecting content, editing, verification and publication on the website jogjaprov.go.id. Content on the jogjaprov.go.id also has several categories, including infrastructure, economics, society, culture, health, education and tourism. This research aimed to analyze the management of jogjaprov.go.id website in realizing the governance of the special region of Yogyakarta in 2019. The research methods in this study were qualitative descriptive with the collection of data through interviews, observations and documentation. The data validity test was through data triangulation. The results showed that the management of the website underwent a change of task from earlier that manages the Department of DIY Communication and informatics, then now moved to public relations of DIY regional government. It can be noted that the public relations of the DIY regional government have been utilizing the website as an information disclosure media to achieve good governance with one aspect of transparency, but the monitoring and evaluation of website content have not been running quite well. As for the website management of public relations of DIY regional government is done through searching and collecting content, editing, verifying and publishing on jogjaprov.go.id.
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Wang, Xin, Yue Han, Xuan Feng, Yun-Zhen Li, Bao-Xiang Qin, Ji-Jing Luo, Zheng Wei, Yong-Fu Qiu, Fang Liu, and Rong-Bai Li. "Breeding of Indica glutinous cytoplasmic male sterile line WX209A via CRISPR/Cas9 mediated genomic editing." Czech Journal of Genetics and Plant Breeding 55, No. 3 (June 17, 2019): 93–100. http://dx.doi.org/10.17221/197/2017-cjgpb.
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Glutinous cytoplasmic male sterile (CMS) line is necessary to select hybrid glutinous rice combination with high yield and quality. To develop glutinous CMS with low amylose content, in this study, we firstly knocked out the granule-bound starch synthase OsWaxy in 209B using CRISPR/Cas9 mediated genome editing technology and successfully obtained a glutinous maintainer line WX209B. Comparing with maintainer line 209B, WX209B showed decreased amylose contents and similar agronomic characters. And then, through one generation of hybridization and two generations of backcrossing with WX209B as the male parent and 209A as the female parent, the glutinous CMS line WX209A was successfully achieved. Our study provides a strategy to efficiently breed for the glutinous cytoplasmic male sterile line by combining CRISPR/Cas9-mediated gene editing technology with conventional backcross breeding method in a short period, which prepares the ground for further breeding of hybrid glutinous rice variety.
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Clarke, Patricia. "Literary Sidelights on Wartime Brisbane." Queensland Review 11, no. 2 (December 2004): 41–57. http://dx.doi.org/10.1017/s1321816600003706.
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There have been several anecdotal accounts of the literary scene in Brisbane during World War II and numerous references in more general works. In 2000,Queensland Reviewpublished some reminiscences of writers Estelle Runcie Pinney, Don Munro, Val Vallis and David Rowbotham, under the title ‘Writing in Brisbane during the Second World War’. Some of the more important general works include Judith Wright's ‘Brisbane in Wartime’, Lynne Strahan's history ofMeanjinand Judith Armstrong's biographical work on the Christesens,The Christesen Romance. My interest in this subject arose from editing Judith Wright's autobiography,Half a Lifetime, published in 1999, and recently in editing, with her daughter, letters between Judith Wright and Jack McKinney which were mainly written in Brisbane in the later years of the war and the immediate postwar period. Initially my purpose was to gather information to elucidate people or events mentioned in these writings, but my interest widened to embrace more general information about the period. My research led me to the conclusion thatMeanjinand its editor Clem Christesen were catalysts for many of the literary activities in Brisbane during World War II, not just among resident Australians, but among troops temporarily stationed in Brisbane — particularly Americans, whom Christesen cultivated and published. This article records a few glimpses of literary life in Brisbane, and incidentally in the rest of the country, during a period described by Patrick Buckridge as never having been researched ‘in enough detail’.
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Evgeny D., Eremenko. "Odessa Film Studio and Lenfilm: editorial practices (1960–1980s)." Vestnik of Saint Petersburg State University of Culture, no. 1 (50) (2022): 46–53. http://dx.doi.org/10.30725/2619-0303-2022-1-46-53.
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The purpose of this article is to update the experience of editorial practices conducted at two Soviet film studios during their heyday (1960-1980s). With the difference in the scale of film production of the Odessa Film Studio and Lenfilm, there are obvious analogies in their creative and organizational policies of the specified period. One of the key factors contributing to the creation of outstanding films is the initiative-taking work of the editorial staff. The parallels of the editorial work of film studios were manifested in such aspects as the preparation of a production plan („scenario portfolio “), the process of creating a film (from the consideration of a scenario application to the „delivery “of a finished film). Along with the achievements, there were conflicts that also became part of the history of film editing. A special topic is the role of editing and censorship in the work of prominent representatives of the „author’s cinema “. The artistic heritage of both film studios already in the post-Soviet period is museumified and reflected in the exhibition spaces, with the active participation of film editors: D. Ivaneev, S. Kolomoets at Lenfilm and V. Kostromenko, G. Lazareva, E. Martsenyuk at the Odessa Film Studio).
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QIU, X., Q. FU, C. MENG, S. YU, Y. ZHAN, L. DONG, T. REN, et al. "Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection." Acta virologica 60, no. 01 (2016): 71–77. http://dx.doi.org/10.4149/av_2016_01_71.
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Varga, Mihaela, and Ana Maria Vutan. "The efficiency of rehabilitation programs in the case of unoperated lumbar disc herniations." Timisoara Physical Education and Rehabilitation Journal 12, no. 23 (December 1, 2019): 26–31. http://dx.doi.org/10.2478/tperj-2019-0010.
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AbstractIntroduction: More and more young people with low back pain address family doctors or orthopaedists, being subsequently directed to the medical rehabilitation centres. Recent studies have shown that the medication only, prescribed in these cases, is not sufficient for the complete reintegration of these people into the workplace and into society. Physical exercises play an important role in the rehabilitation of these subjects.Aim: We conducted this study starting from the hypothesis that regular exercise can reduce pain and improve the well-being of patients diagnosed with lumbar disc herniation.Methods: The study was conducted at the “Politehnica” University of Timisoara within the Department of Physical Education and Sports, between September and November 2019. Ten subjects diagnosed (both clinically and by imaging) with lumbar disc herniation were included in the study. All patients followed an exercise program 3 times a week, for 90 days. As evaluation methods we used: the subjective pain evaluation scale (VAS scale) and the health assessment questionnaire (HAQ).Results: All the parameters followed in this study were improved following the application of the physical exercise program (muscle stretching, toning of the back and abdomen muscles, and as a result of the correct implementation of the notions of ergonomics at work and at home). In conclusion, we consider it is necessary to implement a protocol of exercises performed regularly for a long period in the case of patients with lumbar pain secondary to disc herniation.
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Kotecha, B. "0642 A Novel Daytime Intra-Oral Neuromuscular Stimulation Therapy in Simple Snorers: Objective Improvement in Snoring." Sleep 43, Supplement_1 (April 2020): A245. http://dx.doi.org/10.1093/sleep/zsaa056.638.
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Abstract Introduction The reduction in pharyngeal muscle tone in the upper airway is a pivotal factor in snoring and obstructive sleep apnoea (OSA).There is accumulative evidence that pharyngeal exercises can reduce snoring and OSA. We present a novel device SnooZeal® that uses daytime awake neuromuscular electrical stimulation (NEMS) as an application to induce toning of the tongue muscles. This study investigates objective changes in snoring and respiratory parameters with this device. Methods Prospective cohort study of 100 simple snorers was conducted. Objective snoring and respiratory parameters were recorded with 2 consecutive WatchPat sleep studies before and after treatment. SnooZeal® device was used for 20 minutes once a day for a 6 week period. Secondary outcome measures using visual analogue scale reporting of snoring by patient and Epworth Sleepiness Score (ESS) were recorded. Results Objective reduction of snoring was noted on the sleep studies in 95% with an average reduction of 48%. Subjectively, the visual analogue scale reported by partners similarly demonstrated reduction in 95% of the patients with an average reduction of 40%. Conclusion This prospective cohort study demonstrates a notable improvement in both objective and subjective parameters of snoring and respiratory indices. SnooZeal® offers a novel approach to reduce snoring by utilising intra-oral neuromuscular electrical stimulation. This could be a preferred option for patients as it alleviates the need of using an oral device during sleep. Support
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GILLANI, Syed F. A., Adnan RASHEED, Yasir MAJEED, Huma TARIQ, and Peng YUNLING. "Recent advancements on use of CRISPR /Cas9 in maize yield and quality improvement." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 49, no. 3 (September 27, 2021): 12459. http://dx.doi.org/10.15835/nbha49312459.
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CRISPR/Cas is a genome editing technique, permits accurate improvement of fiscally significant yield species by transgenic and non-transgenic strategies. We have reviewed CRISPR/Cas9 with or without DNA solution design in both maize as samples to redesign tolerance against dry season obstruction, improving seed’s oil contents production, and a gift of herbicide strength. Fundamentally, by exploiting the technologies of CRISPR/Cas9, development with late advances in plant tissue culture can be brought directly into monetarily significant genotypes. The various crop species are major agricultural products and play an indispensable role in sustaining human life. Over a long period, breeders strove to increase crop yield and improve quality through traditional breeding strategies. Today, many breeders have achieved remarkable results using modern molecular technologies. Recently, a new gene-editing system named the clustered regularly interspaced short palindromic repeats CRISPR/Cas9 technology has also improved crop quality. It has become the most popular tool for crop improvement due to its versatility. It has accelerated crop breeding progress by its precision in specific gene editing. This review summarizes the current application of CRISPR/Cas9 technology in crop quality improvement. It includes the modulation in appearance, palatability, nutritional components, and other preferred traits of various crops. Assortment created through such CRISPR/Cas9 engaged advanced raising procedures can be muddled from the regularly happening assortment and appropriately should be quickly open for commercialization.
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Proskudina, G. Yu, and K. A. Kudim. "About technologies of use of external data on creating and editing of encyclopedic texts." PROBLEMS IN PROGRAMMING, no. 1 (2017): 067–82. http://dx.doi.org/10.15407/pp2017.01.067.
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The paper discusses developing of Wikidata project, the query web service and the query language. The workflow of the web service, query language and result output forms are demonstrated with plenty of examples. Wikidata usage technology by third-party systems is developed.In this concern ExternalData extension which is part of MediaWiki software is considered. Additionally the instruction for installation and configuration of the extension is presented. During test period ExternalData extension was improved. procedure for automatic list generation in wiki page is developed.
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Morozov, S. N. "I. A. Bunin’s Story "The Cicadas": History of the Text." Russkaya literatura 3 (2020): 129–41. http://dx.doi.org/10.31860/0131-6095-2020-3-129-141.
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The paper investigates the history of the text of I. A. Bunin’s story "The Cicadas" (later called "The Night"), with all the surviving autographs, publications of this text, as well as the author’s later period notes on the printed copies of the story taken into account. All stages of the author’s work on the story are studied (cuts, editing, additions, etc.). The most illustrative examples of discrepancies in different sources of the text are presented.
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Trehearne, Brian. "Canadian Modernism at the Present Time." Modernist Cultures 13, no. 4 (November 2018): 465–95. http://dx.doi.org/10.3366/mod.2018.0226.
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The article critiques major debates in Canadian modernist criticism and assesses their impact on readerships in the present time of anti-elitism, resurgent nationalisms, and widening distrust of expertise. Feminist critics articulate women writers' conflictual relations to the modernist canon and have restored or introduced disregarded female poets to an academic readership. Commentators on ‘antimodernism’ defend traditional writers of the period against modernist ridicule and suggest an antimodernist nostalgia for indigenous national authenticity within modernist writing itself. Leftist critics emphasize the political radicalism of major Canadian modernist writers as well as promoting and editing little-known authors who share their politics. Theorists critique the editorial practices of the field and promote genetic editing and digital publishing. Three less prominent trends are likelier to provoke and keep new readers for Canadian modernism: philosophically and ethically driven criticism; renewed attentiveness to cosmopolitanism in Canadian modernist discourse; and candid engagement with the problem of Canadian modernism's derivation from modernisms elsewhere.
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Žitnik Serafin, Janja. "The editing of Louis Adamic's book The Eagle and the Roots." Acta Neophilologica 22 (December 15, 1989): 69–87. http://dx.doi.org/10.4312/an.22.0.69-87.
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The Eagle and the Roots is Louis Adamic's last book and, in his own opinion, his most important one. The printed version of that work is an expurgated version of the author's typescript which is preserved in several incomplete copies, kept in various public and private archives in Yugoslavia and in the United States. The work was written on the basis of the author's personal impressions during his second visit to his native land in 1949. The published version of The Eagle and the Roots discusses the political and economic conditions in Yugoslavia in 1949, the moods of the Yugoslav people, their top politicians and intellectuals at the time of the first five-year plan (Book One), including a biography of Josip Broz Tito until 1945 with an outline of the most important events in the country before and during World War II (Book Two). In various passages scattered in both books, it describes the selfsacrifice and the resistance of the Yugoslav people during the Liberation War. An important subject is the dissention between Tito and Stalin which had its germs in the prewar period. The author follows its development through the war and during the first years after the liberation until the Cominform resolution in June 1948.
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Žitnik Serafin, Janja. "The editing of Louis Adamic's book The Eagle and the Roots." Acta Neophilologica 22 (December 15, 1989): 69–87. http://dx.doi.org/10.4312/an.22.1.69-87.
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The Eagle and the Roots is Louis Adamic's last book and, in his own opinion, his most important one. The printed version of that work is an expurgated version of the author's typescript which is preserved in several incomplete copies, kept in various public and private archives in Yugoslavia and in the United States. The work was written on the basis of the author's personal impressions during his second visit to his native land in 1949. The published version of The Eagle and the Roots discusses the political and economic conditions in Yugoslavia in 1949, the moods of the Yugoslav people, their top politicians and intellectuals at the time of the first five-year plan (Book One), including a biography of Josip Broz Tito until 1945 with an outline of the most important events in the country before and during World War II (Book Two). In various passages scattered in both books, it describes the selfsacrifice and the resistance of the Yugoslav people during the Liberation War. An important subject is the dissention between Tito and Stalin which had its germs in the prewar period. The author follows its development through the war and during the first years after the liberation until the Cominform resolution in June 1948.
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Schiffman, Lawrence H. "The Dead Sea Scrolls and the History of the Jewish Book." AJS Review 34, no. 2 (November 2010): 359–65. http://dx.doi.org/10.1017/s0364009410000383.
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The complicated process whereby the biblical books took shape and were copied and transmitted in biblical times can only be partly reconstructed based on biblical evidence, with the help of ancient Near Eastern parallels. Clearly, the biblical era constitutes the first stage in the history of the Jewish book, or more correctly,theJewish bookpar excellence. However, for the period immediately following, the Second Temple period, the level of documentation for creating, editing/redacting, and copying and disseminating Jewish books is now enormous due to the discovery, publication, and analysis of the Dead Sea Scrolls. While this information relates directly to the period in which the Scrolls were copied, from the last part of the third centurybcethrough the early first centuryce, it also allows us a model with which to supplement our understanding of the biblical period, and much of it is directly relevant to the rabbinic period in which most of the same scribal conventions were in use.
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Chaudhary, Juhi, Rupesh Deshmukh, and Humira Sonah. "Mutagenesis Approaches and Their Role in Crop Improvement." Plants 8, no. 11 (October 31, 2019): 467. http://dx.doi.org/10.3390/plants8110467.
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Induced mutagenesis is one of the most efficient tools that has been utilized extensively to create genetic variation as well as for identification of key regulatory genes for economically important traits toward the crop improvement. Mutations can be induced by several techniques such as physical, chemical, and insertional mutagen treatments; however, these methods are not preferred because of cost and tedious process. Nonetheless, with the advancements in next-generation sequencing (NGS) techniques, millions of mutations can be detected in a very short period of time and, therefore, considered as convenient and cost efficient. Furthermore, induced mutagenesis coupled with whole-genome sequencing has provided a robust platform for forward and reverse genetic applications. Moreover, the availability of whole-genome sequence information for large number of crops has enabled target-specific genome editing techniques as a preferable method to engineer desired mutations. The available genome editing approaches such as ZFNs (Zinc Finger Nucleases), transcription activator like effector nucleases (TALENS), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated9 (Cas9) endonuclease have been utilized to perform site-specific mutations in several plant species. In particular, the CRISPR/Cas9 has transformed the genome editing because of its simplicity and robustness, therefore, have been utilized to enhance biotic and abiotic stress resistance. The Special Issue of Plants highlights the efforts by the scientific community utilizing mutagenesis techniques for the identification of novel genes toward crop improvement.
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Kadhim, N. A., S. Abdullah, and A. K. Ariffin. "Effect of the fatigue data editing technique associated with finite element analysis on the component fatigue design period." Materials & Design 32, no. 2 (February 2011): 1020–30. http://dx.doi.org/10.1016/j.matdes.2010.07.029.
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Choi, Seung-Won. "A Study on the Pace of Film according to the Change of Time Period : Focused on Video Editing." Korean Journal of animation 15, no. 2 (June 30, 2019): 104–21. http://dx.doi.org/10.51467/asko.2019.06.15.2.104.
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Rabiu, Safianu, and Robert K. Rose. "Demographic response of the Gambian Gerbil to seasonal changes in Savannah fallow fields." Folia Oecologica 46, no. 1 (May 1, 2019): 1–9. http://dx.doi.org/10.2478/foecol-2019-0001.
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AbstractThe Savannah gerbil, Gerbilliscus gambianus (Muridae: Gerbillinae) is important to the ecological relations of the dry grassland ecosystem of West Africa, as well as, being a zoonotic agent of human diseases and potential crop pest. We examined the impact of seasonal changes on the population dynamics of G. gambianus in northern Nigeria, by completing population estimates using capture–mark–recapture (CMR) and indirect population density indices (PDI) methods. The latter included fecal pellet counts and limited spotlightening. During 1990–1992 we collected both CMR and PDI data, and established their relationship by regression, thus calibrating the PDI values to CMR estimator. We also completed a separate, PDI only, study during 2015–2017, and estimated monthly densities indirectly by toning the PDI values to population sizes in the CMR estimator. The lowest declines (<20 gerbils ha−1) were in mid rains (July–August), and highest increases (>90 gerbils ha−1) were after the rains (October–January). Seasonal effects on densities were significant during 1990–1992 but not during 2015–2017. There were improved survival rates for both adults (0.95) and young (0.83), adult capture probability (0.56), and mean monthly recruitment of young (23) after the rains. There was no significant change in the overall population dynamic pattern of G. gambianus over a 25-year period. Because G. gambianus did not maintain colonies inside farmlands cultivated by rain or irrigation, and its tendency for large population drops in mid-rains, we are in doubt of its potential as crop pest in northern Nigeria.
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Ballesteros, Soledad, Jennifer Rieker, josé M. Reales, julia Mayas, María Pilar Jiménez, Antonio Prieto, and Pilar Toril. "IS COMBINED TRAINING MORE EFFECTIVE THAN SINGLE-DOMAIN TRAINING: A RANDOMIZED CONTROLLED TRIAL WITH OLDER ADULTS." Innovation in Aging 3, Supplement_1 (November 2019): S721. http://dx.doi.org/10.1093/geroni/igz038.2644.
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Abstract Previous research suggests that both cognitive training and physical exercise help to maintain brain health and cognitive functions that decline with age. The main objectives of this four-arms RCT are (1) to investigate the synergetic effects of a group-based multidomain training program that combines cognitive video-game training with physical exercise, in comparison to those produced by cognitive training combined with physical control activity, physical training combined with cognitive control activity, or a combination of both control activities; (2) to investigate in a memory-based task switching task whether event Related Potential (ERP) latencies of the P2 component are shorter, and N2 and P3b components are enhanced after training; and (3) to find out whether possible enhancements persist after a 3-month period without training. One hundred and twenty participants will be randomly assigned to one of the four combinations of cognitive training and physical exercise. The cognitive component will be either video-game training (cognitive intervention, CI) or video games not specifically designed to train cognition (cognitive control, CC). The physical exercise component will either emphasize endurance, strength, and music-movement coordination (exercise intervention, EI) or stretching, toning and relaxation (exercise control, EC). This RCT will investigate the short and long-term effects of combined multi-domain training compared to cognitive training and physical training alone, on executive control and memory functions of healthy older adults, in comparison with the performance of an active control group. This trial is an ongoing project started in 2018. Trial registration: Clinicaltrials.gov ID: NCT03823183; https://register.clinicaltrials.gov/
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Knežević, Snežana. "Aktivnosti Jovana Radulovića u izdavaštvu (BIGZ)." Узданица 18, no. 2 (November 2021): 223–26. http://dx.doi.org/10.46793/uzdanica18.2.223k.
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The paper gives an overview of the editorial work of Jovan Radulović in the publishing house BIGZ, in the period from 1983 to 2001. His role in making publishing plans is described,within the editions for which he was in charge, as well as his principles in editing books. A special attention was paid to the last decade of his editorial work, when Serbian culture shared the difficult fate of the people, and in which the great writer showed great organizational and human virtues.
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Otting, Gottfried, and Kurt Wüthrich. "Heteronuclear filters in two-dimensional [1H, 1H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions." Quarterly Reviews of Biophysics 23, no. 1 (February 1990): 39–96. http://dx.doi.org/10.1017/s0033583500005412.
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The use of heteronuclear filters enables the editing of complex 1H nuclear magnetic resonance (NMR) spectra into simplified subspectra containing a lesser number of resonance lines, which are then more easily amenable to detailed spectral analysis. This editing is based on the creation of heteronuclear two-spin or multiple-spin coherence and discrimination between protons that do or do not participate in these heteronuclear coherences. In principle, heteronuclear editing can be used in conjunction with one-dimensional or multidimensional 1H-NMR experiments for studies of a wide variety of low-molecular-weight compounds or macromolecular systems, and is implicitely applied in a wide range of heteronuclear NMR experiments with proton detection (e.g. Bax et al. 1983; Griffey & Redfield, 1987). In the present article we shall focus on the use of heteronuclear filters in two-dimensional (2D) [1H, 1H]-NMR experiments. The selection of the material covered was primarily motivated by its impact on the practice of protein structure determination in solution, and on NMR studies of intermolecular interactions with biological macromolecules. Section 2 surveys potential applications of heteronuclear filters in this area. The remainder of the article is devoted to an introduction of the theoretical principles used in heteronuclear filters, and to a detailed description of the experimental implementation of these measurements. In writing the review we tried to minimize redundancy with the recent article in Quarterly Review of Biophysics by Griffey & Redfield (1987) and to concentrate on experiments that were introduced during the period 1986–9.
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Souza, Andréa Carolina Santos de, Marcos Paulo Gonçalves de Rezende, Paulo Luiz Souza Carneiro, Bárbara Machado Campos, and Carlos Henrique Mendes Malhado. "Editing and modeling of milk production data for genetic evaluation of Murrah buffaloes." Pesquisa Agropecuária Brasileira 52, no. 12 (December 2017): 1261–67. http://dx.doi.org/10.1590/s0100-204x2017001200015.
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Abstract: The objective of this work was to assess the effect of editing and modeling of milk production data for genetic evaluation of Murrah buffaloes. Six strategies for evaluating milk production were analyzed: observed milk production (OMP); adjustment of milk production data to 305 (MP305) and 270 (MP270) days of lactation; removal of the 5 (MP5%) and 10% (MP10%) shortest lactation periods; and milk production along the lactation period as linear covariate (MPCO). Genetic parameters were estimated using the Bayesian inference, with heritability estimates of 0.19 to 0.23 and repeatability estimates of 0.35 to 0.36. Sires classified by OMP were high correlated to those classified by the other models, however, correlations to MP270, MP305 and MPCO decreased when considering only the best 20% sires. OMP showed greater differences in absolute mean deviations when compared with MPCO, MP270 and MP305. The strategies of analysis had similar heritabilities and stabilities. However, changes in the ranking of sires with better classifications, due to overestimation of genetic values, as occurred in the models MP305, MP270 and MPCO, may lead to a decrease in the genetic progress of the herd.
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Weining, Sun, and Zhao Cheli. "Applications of virtual reality modeling language technology for COVID-19 pandemic." Journal of Intelligent & Fuzzy Systems 39, no. 6 (December 4, 2020): 8643–53. http://dx.doi.org/10.3233/jifs-189260.
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During COVID-19 pandemic, researchers have used innovative technologies for fast tracking the development to end this pandemic. Virtual Reality (VR) has offered an imperative role for fighting this pandemic, through audiovisual-based virtual communication. Virtual reality modeling language (VRML), as an international standard of virtual reality, has developed rapidly. VRML expanded the function of script node by introducing Java and script programs written in java script language. This paper presents a VRML method. Libraries and platoons are virtualized to meet the normal use of users. In principle, any text editing system can be used for VRML programming, but some editing systems have few related functions and are not suitable for large-scale VRML Scene Design. The VRML algorithm proposed in this paper can be applied to large buildings. The VRML algorithm proposed in this paper is compared with the traditional algorithm. The VRML algorithm proposed in this paper is superior to the traditional algorithm in the aspects of realism, interactivity, design rationality and execution speed. The practicability of the VRML algorithm is proved. It provides help for people who are inconvenient to go out during the protection period of covid-19.
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Qureshi, Muhammad Asif. "Age and knowledge of morphosyntax in english as an additional language: grammatical judgment and error correction." International Review of Applied Linguistics in Language Teaching 58, no. 1 (March 26, 2020): 29–50. http://dx.doi.org/10.1515/iral-2015-0062.
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AbstractResearch on age and second language acquisition (L2A) is vast, but inconclusive. Such research has mainly been motivated by the Critical Period Hypothesis (CPH), which postulates that language acquisition becomes extremely difficult after the onset of puberty. Also, there is a lack of research on age and third/additional language (L3/Ln) learning. To fill this gap, this article examines differences in morphosyntactic knowledge between early and late learners of English as a L3/Ln. In this study, ‘early’ and ‘late’ learners are those participants first exposed to English as a medium of instruction (MOI) in 1st and 11th grades, respectively. Participants’ morphosyntactic knowledge was assessed based on two tasks: (a) a Grammaticality Judgment Task (GJT) and (b) an editing task. Three hundred and thirty five undergraduate and graduate students from two universities in Pakistan voluntarily participated in the research. Results of the group comparisons showed no statistically significant differences between early and late learners on the GJT; however, on the editing task, a modest but significant difference was observed between the two groups, with late learners scoring higher. This finding contradicts the predictions of the CPH.
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Vargha, Katalin. "Riddles in the Manuscript and Print Version of a 19th-Century Collection." Acta Ethnographica Hungarica 66, no. 1 (April 11, 2022): 79–95. http://dx.doi.org/10.1556/022.2021.00017.
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Abstract Scholarly publication of folk riddles in Hungary started in the mid-19th century. Among the early sources was the first classic collection of Hungarian folktales, Eredeti népmesék [Authentic Folktales], compiled by László Arany, which includes a separate chapter comprising 54 riddle tales. Manuscripts related to this publication were found in the Hungarian Academy of Sciences among other collections from the 19th century and identified in the 1960s as having been recorded by members of the Arany family. The manuscripts contain all the riddles published by László Arany, along with 25 riddle texts that remained unpublished. Comparison of the two sources reveals the editing process: the selection and arrangement of the material, along with the text modifications applied by László Arany. The first part of this article consists of a few terminological notes on tales and riddle tales in 19th-century Hungary, followed by the description of the riddle material in the manuscripts associated with the Arany family. In the second part the author presents in more detail the editing process which shows a far higher degree of conscious editorial attention than other publications of folk riddles in the period.
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Gundry, Michael C., Lorenzo Brunetti, Dimitrios Laurin Wagner, Joanne Hsu, Mireya Paulina Velasquez, Stephen Gottschalk, Cliona M. Rooney, and Margaret Goodell. "Fast and Efficient Gene Editing in Human Hematopoietic Cells." Blood 128, no. 22 (December 2, 2016): 4704. http://dx.doi.org/10.1182/blood.v128.22.4704.4704.
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Abstract Although CRISPR/Cas9 is now accessible to a wide variety of cell-types and model systems, efficient editing of hematopoietic cells remains challenging. We have designed and optimized a protocol for rapid and efficient delivery of CRISPR/Cas9 to hematopoietic cell lines and primary cells. Combining electroporation's high transfection efficiency and the reduced cellular toxicity of Cas9 protein versus plasmid in suspension cells, we are able to produce highly efficient gene disruption and knock-in in a variety of human cell types, including acute myeloid leukemia (AML) cell lines, B-acute lymphoid leukemia (ALL) cell lines, primary T-lymphocytes and primary hematopoietic stem/progenitor cells (HSPCs). Our protocol involves rapid sgRNA template design and PCR amplification, followed by overnight in-vitro transcription, sgRNA purification and sgRNA-Cas9 ribonucleoprotein (RNP) formation. We began by testing the protocol on three AML cell lines, in which we observed up to 98% knock-out (KO) of the ubiquitous hematopoietic marker CD45 (%CD45neg cells by flow cytometry: HL-60 - 98%, OCI-AML2 - 92%, Kasumi - 87%). Using multiple guides, we also induced KO of two B-cell markers (CD19 and CD22) in three B-cell cancer cell lines (BV173, Daudi and Nalm-6). In these three cell lines, up to 70% of cells displayed combined loss of both cell surface receptors, indicating disruption of all four alleles (%CD19negCD22neg cells by flow cytometry: BV-173 - 58%, Nalm-6 - 70%, Daudi - 18%). We then optimized our editing strategy in human primary cells. We observed highly efficient CD45 loss (86±2%; n=3) in activated T-cells by flow cytometry and confirmed this KO frequency using high-throughput sequencing. We next measured CD45 gene disruption in CD34+ HSPC cells isolated from cord blood and found that our system had 75±10% editing efficiency (n=4). Importantly, a 48-hour period of cytokine stimulation with SCF/TPO/FLT3L prior to electroporation was required for efficient gene knockout (0hr: 8±4%, 24hr: 41±12%, 48hr: 73±16%; p0vs24=0.0002, p24vs48=0.003; n=8). Our protocol induced efficient gene disruption of several relevant targets in CD34+ cells including DNMT3A ex7 (69±4%; n=5), DNMT3A ex10 (86±14%; n=10) and NR3C1 (75±6%; n=5), and near complete loss of protein by western blot. To verify that the edited CD34+ HSPCs cells maintained engraftment and multilineage differentiation capacity, we transplanted Cas9 only (n=8) and Cas9/hCD45-sg1 RNP edited cells (n=8) into sub-lethally irradiated NOD scid gamma (NSG) mice. To avoid possible donor-dependent bias, each experimental pair (i.e. one Cas9 only replicate and one Cas9/hCD45-sg1 RNP treated replicate) was performed on cells derived from a single cord blood. Human cells successfully engrafted in the bone marrow of 16/16 recipients and spleens of 13/16 recipients. Importantly, we observed significant levels of engraftment by hCD45neg cells in the bone marrow of 7/8 mice and in the spleen of 5/8 mice transplanted with Cas9/hCD45-sg1 RNP edited cells (Figure 1A; Figure 1B shows one representative pair). High-throughput sequencing confirmed that engrafted human cells in BM displayed hCD45indel frequencies consistent with the flow cytometry data. Finally, we considered whether these editing strategies could be used to introduce specific point mutations into primary human HSPCs using Cas9-mediated homology directed repair (HDR). Single-stranded oligonucleotide HDR templates (ssODNs) with 90bp homology arms to the human CD45 locus were designed to introduce three basepair changes, two of which result in the generation of a BsiWI site near the CD45-sg1 cut site. High-throughput sequencing of treated human HSPC samples revealed efficient precise knock-in (22±4%; n=4) of the mutant allele. In conclusion, we describe a fast and efficient protocol for both gene disruption and targeted gene editing of human hematopoietic cells, including HSPCs, using the CRISPR/Cas9 system. The ability to quickly and efficiently edit primary human HSPCs using HDR makes it possible to introduce or repair genetic variants identified in association with hematologic diseases such as leukemia or bone marrow failure. Moreover, the high efficiency of this system offers the possibility to perform large-scale combinatorial gene editing in HSPCs to model complex mutational landscapes. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Pivarciova, Lenka, Hanka Vaneckova, Jan Provaznik, Bulah Chia-hsiang Wu, Martin Pivarci, Olga Peckova, Olga Bazalova, et al. "Unexpected Geographic Variability of the Free Running Period in the Linden Bug Pyrrhocoris apterus." Journal of Biological Rhythms 31, no. 6 (October 5, 2016): 568–76. http://dx.doi.org/10.1177/0748730416671213.
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Circadian clocks keep organisms in synchrony with external day-night cycles. The free running period (FRP) of the clock, however, is usually only close to—not exactly—24 h. Here, we explored the geographical variation in the FRP of the linden bug, Pyrrhocoris apterus, in 59 field-lines originating from a wide variety of localities representing geographically different environments. We have identified a remarkable range in the FRPs between field-lines, with the fastest clock at ~21 h and the slowest close to 28 h, a range comparable to the collections of clock mutants in model organisms. Similarly, field-lines differed in the percentage of rhythmic individuals, with a minimum of 13.8% and a maximum of 86.8%. Although the FRP correlates with the latitude and perhaps with the altitude of the locality, the actual function of this FRP diversity is currently unclear. With the recent technological progress of massive parallel sequencing and genome editing, we can expect remarkable progress in elucidating the genetic basis of similar geographic variants in P. apterus or in similar emerging model species of chronobiology.
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Pombeni, Paolo, and Giuliana Nobili Schiera. "Alcide de Gasperi: 1881–1954–a political life in a troubled century." Modern Italy 14, no. 4 (November 2009): 379–97. http://dx.doi.org/10.1080/13532940903237409.
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Alcide De Gasperi's political life spanned the first half of the twentieth century. It went from his education in a small local environment, but within the multinational setting of the Austro-Hungarian Empire, to his period of enforced, yet intellectually very productive, public silence during the period of Fascist Italy, and then to his period in the limelight during the years of postwar reconstruction, the re-establishment of democracy and the construction of European unity. A group of scholars has documented the evolution of an outstanding leader by publishing a critical edition of De Gasperi's Scritti e discorsi politici, a collection of writings and speeches from the outset of his career until the end of his life. This article illustrates the research that has been carried out so far; the criteria behind the collection and editing of sources on De Gasperi; and the chronological periods and thematic issues around which the whole body of De Gasperi's political writings have been collated.
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Kanda, Yui. "Kashan Revisited: A Luster-Painted Ceramic Tombstone Inscribed with a Chronogram Poem by Muhtasham Kashani." Muqarnas Online 34, no. 1 (October 8, 2017): 273–86. http://dx.doi.org/10.1163/22118993_03401p011.
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The production site(s) of luster-painted ceramics from the fifteenth century onward have yet to be precisely identified due to a paucity of material and textual evidence regarding ceramic production during this period. This study focuses on a hitherto undeciphered Persian poem, which was inconspicuously inscribed in the unskilled nastaʿlīq script on a luster-painted ceramic tombstone dated 25 Jumada II 967 (March 23, 1560). This poem can be identified as a qiṭʿa by Muhtasham Kashani (d. 1588), a renowned court poet who spent his entire life in Kashan. The identification of this poem is particularly important for two reasons. First, it may imply that luster-painted ceramics were produced in Kashan during the early Safavid period. Second, it suggests that there is indeed potential for using epitaphs as historical sources, as the poem in question sheds valuable light on the editing process of Haft dīvān, as well as on the social context of the growing popularity of chronogram poems in Iran during this period.
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Bosanquet, Antonia. "One Manuscript, Many Books: The Manuscript and Editing History of Aḥkām ahl al-dhimma." Die Welt des Islams 61, no. 2 (January 19, 2021): 153–80. http://dx.doi.org/10.1163/15700607-61010011.
Full textAbstract:
Abstract Aḥkām ahl al-dhimma is a book of regulations about Christian and Jewish subjects of Islamic rule, written by the Ḥanbalī jurist and theologian Ibn Qayyim al-Jawziyya (d. 751/1350). It is an important resource for historical studies of non-Muslim minorities in the Mamluk period and is often cited as a normative text in present-day Muslim discussions about Muslim-non-Muslim relations. This article gives an insight into the history of the only surviving manuscript of Aḥkām ahl al-dhimma and the unusual process by which the first printed edition was compiled. It shows that the movement of the manuscript was largely a result of Ibn Taymiyya’s and Ibn al-Qayyim’s more general popularity in specific geographic regions than the authority of the text itself, and that individuals’ religious-intellectual interests were decisive for the publication of a printed edition in 1961. It also shows that the unusual editing process impacted on the reliability of the printed editions available today, the majority of which are financed by Saudi institutions.
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O’Dell, Allison Jai. "Yuming He. Home and the World: Editing the “Glorious Ming” in Woodblock-Printed Books of the Sixteenth and Seventeenth Centuries. Cambridge, Mass.; London: Harvard University Asia Center, 2013. xi, 343 p. ISBN 978-0674066809. $35.96." RBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage 16, no. 1 (March 1, 2015): 74–76. http://dx.doi.org/10.5860/rbm.16.1.440.
Full textAbstract:
Home and the World: Editing the “Glorious Ming” in Woodblock-Printed Books of the Sixteenth and Seventeenth Centuries is both a history of Ming book culture and a thoughtful meditation on the practice of book history. Its prose style is scholarly, but enjoying Home and the World does not require prior knowledge of a specialized discipline. Yuming He offers an engaging introduction to the book as an artifact of culture and reveals the reception and use of texts given different social and personal contexts.The late Ming was a fascinating period in the growth of book consumption. Expanded population, urbanity, and . . .