Dissertations / Theses: 'EDD'

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Aldred, Elaine Mary. "The landscape of EdD programmes in England." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52445/.

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Professional Doctorates in Education (EdD) have been established in many universities in England over the last 25 years, but there is little empirical research on them. The studies that do exist are largely literature reviews comparing professional doctorates to traditional doctorates. The empirical work tends to be student-centred, dealing with issues such as motivation for undertaking a professional doctorate; how professional doctorates impact on professional identities; and, the type of critical skills required to engage successfully with a professional doctorate. There has been one empirical survey of EdDs, but this was only as part of a wider survey on the field of professional doctorates. What is missing is twofold: first a consideration of the landscape of EdD programmes; what is being offered where, and how might we understand the nature of the knowledge acquired. Secondly, there is no description of the pedagogical frameworks of EdDs and how these bridge the various knowledge boundaries between theoretical, academic and professional knowledges. This thesis sets out to investigate these issues. The study draws on the theoretical concepts of Basil Bernstein and, in part, Karl Maton’s development of these concepts. Maton’s extension of Bernstein’s horizontal and vertical discourse, the semantics modality of legitimation code theory, was used to situate the EdD programmes in relation to one another with regards to the type of knowledge transmitted and acquired by students engaged in those EdDs. This was done through a survey of the EdD websites, quantifying the discourse of those websites and relevant online documentation related to the programmes. Having mapped the programmes through this survey of publicly available material, three partial case studies were developed, each demonstrating a different knowledge focus and pedagogical approach. I used Bernstein’s concept of classification and framing to describe how the pedagogical process of the EdD might, or might not, weaken the boundaries between theoretical knowledge and professional knowledge thereby making it possible for students to connect the two. The findings showed that most EdD programmes emphasised context-independent knowledge and context-dependent knowledge in broadly equal measure. Diverse students were accommodated within structured curricula in communities of learners, albeit in slightly different ways, by providing a theoretical and pedagogical framework in which the students found commonalities and by drawing on the shared experiences of different professional practices to enrich students’ learning experience. Despite each programme having a different focus, all programmes allowed students to develop their own research focus relevant to their professional practice. The deeper description of the three partial case studies also indicated that although the programme focus was an important part of enabling students to find an EdD which best suited their needs, the pedagogic framework should carry equal weight with regards to facilitating students’ ability to connect theoretical knowledge to professional knowledge. For this reason, the pedagogic approach should also be explicated clearly as part of the online information. There has not been any recent mapping of professional doctorates such as EdDs in England. This research has developed a new approach to this problem that a) sheds light on EdDs in England and b) could be useful in mapping other professional doctorates and investigating knowledge acquisition and production in these disciplines.

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Foley, Virginia P. "Gender and Graduation Demographics for EdD Students." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/5989.

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Hershberger, Jane Boag. "Authentic field-based learning experiences for EdD students." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 134 p, 2009. http://proquest.umi.com/pqdweb?did=1818417441&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Poole, Brian David. "Perspectives on the EdD from academics at English universities." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571874.

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Since first appearing in British universities during the early 1990s, the Doctor of Education (EdD) degree has spread rapidly through the UK higher education sector. However, despite the existence of a single set of Quality Assurance Agency (QAA) descriptors for doctoral level achievement, some in academia have always been willing to describe the EdD, either openly or in private, as inferior to the PhD. This thesis endeavours (through a wide-ranging questionnaire completed anonymously by 27 academics from a total of 16 English universities, and follow-up interviews with seven individuals selected from the original sample) to discover how a sample of those who teach on such programmes (EdD academics) view the EdD, in general terms. For instance, it seeks to ascertain how widespread among EdD academics is the notion that the EdD does not reach the ‘gold standard’ represented by the PhD in Education. As data collection proceeds from the questionnaire to the interviews, the focus narrows to three key topics: specific characteristics of the EdD as compared with the PhD in Education (in terms, for example, of learning experience, programme aims, and modes of assessment); strengths, weaknesses and purposes of the EdD viva voce examination; and the concept of 'originality' as operationalised by EdD academics/examiners in deciding whether or not an EdD candidate/thesis displays 'doctorateness'. A range of informed and sometimes forthright views from EdD academics on these matters is recorded. On the basis of data analysis and interpretation, the thesis concludes with proposals for further, more extensive research, and a call for one of two courses of action: either the abolition of the EdD, or the appointment of a committee to review EdD practices nationally, and to recommend ways of strengthening EdD rigour and reputation.

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Clancy, Jennifer Louise St Vincents hospital UNSW. "Characterisation of the EDD gene and its role in cancer." Awarded by:University of New South Wales. St Vincents hospital, 2005. http://handle.unsw.edu.au/1959.4/27404.

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EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human homologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs'. Edd null mice and hyd mutants display embryonic lethality. EDD is also a multifunctional HECT family E3 ubiquitin protein-ligase, with reported roles in both progesterone action and the DNA damage response. To investigate the possible involvement of EDD in human cancer, several cancer types were analysed for allelic gain or loss (allelic imbalance, AI) at the EDD locus. AI of the EDD locus was most frequent in the serous subtype of ovarian cancer (16/22, 73%) and common in other cancers, including breast cancer (31%). AI is likely to represent amplification of the EDD gene locus rather than loss of heterozygosity, as quantitative RT-PCR and immunohistochemistry showed that EDD mRNA and protein are frequently overexpressed in breast and ovarian cancers. These data imply a potential role for EDD in cancer progression. However, depletion of EDD from cells in culture by RNA interference had very little effect on proliferation and cell survival. To identify EDD-regulated pathways, transcript analysis was performed on EDD-depleted cells. The results suggested that EDD modulates cell-cell communication and the actin cytoskeleton. Consistent with transcript analysis, depletion of EDD from two normal breast cell lines (HMEC-184 and MCF-10A) resulted in altered cell morphology, with decreased cell-cell contacts. This was concurrent with altered beta-catenin (an integral component of adherens junctions) at cell-cell contacts, which was also observed in the developing blood vessels of Edd null mice. Interestingly, total cellular beta-catenin levels were not affected. Furthermore, EDD depletion resulted in a decrease in expression of the cytoskeletal regulators twinfilin and R-RAS, with a simultaneous decrease in MAPK (ERK1 and ERK2) activity. Consistent with disruption of adherens junctions, EDD-depleted mammary acini lost tissue coordination and polarity. These data provide a significant advance in our knowledge of EDD, both in its role in regulating the organisation of cells into higher structures and its potential role in the development of cancer. This has relevance to an understanding of embryonic development and the role of tissue homeostasis in cancer progression.

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Cavazzoni, Marco L. E. "Evaluating the impact of corporate executive leadership programs : impacts on executive behaviors /." Pepperdine University, 2002. http://80-wwwlib.umi.com.lib.pepperdine.edu/dissertations/dlnow/3045143.

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Munoz, Marcia Medicine UNSW. "The EDD protein is a critical mediator in the DNA damage response." Awarded by:University of New South Wales. Medicine, 2006. http://handle.unsw.edu.au/1959.4/25977.

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An intact cellular response to DNA damage is important for the maintenance of genomic stability and tumour prevention. EDD, the human orthologue of Drosophila melanogaster ???hyperplastic discs???, is over-expressed or mutated in a number of common human cancers. EDD is a progestin regulated gene that encodes an E3 ubiquitin ligase involved in cell communication and cell adhesion, and although it has also been implicated in the DNA damage response through its association with DNA damage proteins, a definitive role has yet to be demonstrated. The work presented herein shows that EDD is necessary for an adequate cellular response to double-strand DNA breaks. Cells depleted of EDD exhibit reduced survival, radio-resistant DNA synthesis and failure to maintain G2/M arrest following DNA damage induced by phleomycin exposure. Furthermore, EDD-depleted cells display impaired activating phosphorylation and kinase activity of the checkpoint kinase CHK2 after DNA damage. These effects appear to be largely modulated through a phospho-dependent interaction involving the CHK2 FHA domain and a region of EDD spanning a number of putative FHA-binding threonines. These results identify EDD as a novel mediator in DNA damage signal transduction via CHK2 and emphasise the potential importance of EDD in cancer.

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Lopez, J. "Impact of an online EdD programme on personal development and professional practices." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009510/.

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A professional doctorate in education degree (EdD) is a degree where students contextualize professional knowledge into a “theoretical academic framework” (Quality Assurance Agency, 2015, p. 8). This study’s context is a 100% online EdD programme in the United Kingdom (UK) comprised of students throughout the world. Because online EdD programmes are relatively new, limited knowledge exists about the online EdD phenomenon from the students’ perspectives. In effect, the student voice about the online EdD is nearly absent in the literature but should be considered. How to fulfil the primary aim of the programme, to interrelate theory and professional practice and evoke social change (Costley, 2014), also has received limited attention. Two main aims of this study are: (1) To investigate the impacts of the online EdD learning experiences and outcomes on the participants’ personal and professional development through a phenomenologically-informed lens; and (2) To advance the student voice about learning experiences in online EdD programmes. This thesis is phenomenologically-informed, which enabled an in-depth investigation and a “Textural-Structural Description” (Moustakas, 1994, p. 121). The methods to collect data were interviews and document collection, which offered response triangulation and further analysis. The study results indicated that the participants experienced emotional and social challenges (e.g., cultural and linguistic disconnections and incremental disorienting dilemmas) that the transnational higher education (TNHE) virtual learning environment (VLE) sometimes exacerbated. Five of the eight participants’ stories contained evidence of each transformative learning stage (explored further in section 4.6) (Mezirow, 1991). The majority of the participants applied new knowledge from the online EdD programme to their professional contexts to effectuate social change, which is discussed in Chapters IV-V. This study draws attention to the online EdD phenomenon and furthers the discourse about the impacts of the online EdD on students’ personal and professional development.

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Cooper, Andrea K. "Social physique anxiety and Q-EDD based disordered eating in female aesthetic athletes." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26614.

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The purpose of this study was to examine social physique anxiety (SPA) and disordered eating in female aesthetic athletes. Participants included 144 female competitive athletes (M = 19.0 years, SD = 2.08) from the four aesthetic sports of synchronized swimming, figure skating, jazz dance, and gymnastics. The participants completed the SPA scale (SPAS) and the Questionnaire for Eating Disorder Diagnoses (Q-EDD) (which is a new more accurate measure to assess disordered eating) that has not previously been used with female aesthetic athletes. Results revealed that 59.7% of the participants were classified in the asymptomatic category, 29.9% in the symptomatic category, and 10.4% in the eating disordered category. For the two Q-EDD subcategories, there were no participants classified in the chew/spitting category, and three participants classified in the exercise bulimia nervosa category. Also, it was shown that the eating disordered group and the symptomatic group had significantly higher SPA than the asymptomatic group. Thus, these results indicate that in this subpopulation of athletes, there are many who display eating disorder symptomatology, and suggest that interventions that target SPA and disordered eating in these athletes are needed.

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Benavides, Mario. "Microspherule Protein Msp58 and Ubiquitin Ligase EDD Form a Stable Complex that Regulates Cell Proliferation." Thesis, City University of New York, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3561768.

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A complex molecular network is put into place at specific phases of the cell cycle to prevent unscheduled cell division that could result in malignant cell growth. Emerging evidence shows that still uncharacterized proteins play crucial functions at those cell cycle transition points. Nuclear protein Msp58 and EDD E3 ubiquitin ligase have been implicated in different aspects of cell proliferation and reported to be abnormally expressed in numerous types of cancers. The molecular mechanisms underlying Msp58 and EDD functions, however, are not well understood. The work presented here shows that Msp58 and EDD form a stable protein complex that regulates cell viability and proliferation. Interestingly, knockdown of EDD by RNA interference leads to a significant accumulation of Msp58 protein, which suggests that EDD serves as a negative regulator of Msp58. In addition, our in vivo ubiquitination assays and analyses of various cell lines treated with translational and proteasomal inhibitors demonstrate that Msp58 is regulated post-translationally by the ubiquitin-proteasome pathway. These results imply that EDD ligase activity is involved in this regulatory process. Using flow cytometry analyses and biochemical characterization of Msp58 and/or EDD depleted cells, we show that the Msp58-EDD complex plays important roles in cell cycle progression via the control of cyclin gene expression. In particular, silencing Msp58 and/or EDD alters the protein levels of cyclins B, D and E. Taken together, our data suggest that a set of the biological roles attributed to Msp58 and EDD may be executed in the context of the complex that they form, thereby revealing a novel molecular mechanism for these two proteins to accomplish their functions.

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Sparrman, Victoria. "Tube-tap or Earliest Due Date : What happens when all jobs cannot be completed?" Thesis, Umeå universitet, Institutionen för datavetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184627.

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In this thesis the scheduling algorithms Earliest Due Date (EDD) and Tube-tap were compared to each other. They were compared to see which algorithm generated more net profit. They were compared to each other in four different scenarios. In each scenario there were two different machines and five different jobs. Each machine had a cost and a processing rate, and each job had a length, a deadline, and a profit. In every scenario all jobs could not be completed before their deadline. The net profit was calculated by subtracting the gross profit by the machine cost. The results for the Tube-tap and EDD algorithms were almost the same for both algorithms in the different scenarios. There was one scenario where Tube-tap gained 0.5 more in profit. This was because Tube-tap had 0.5 in machine cost for one of the scenarios. The conclusions was that there should be more experimentation to see how more profitable Tube-tap can be. Specifically, there should be testing on scenarios where all jobs cannot be completed before their deadlines, but the number of operations does not exceed the available space before the last deadline.

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Bashir, Masarra. "The Impact of Land-use change on the Livelihoods of Rural Communities: A case-study in Edd Al-Fursan Locality, South Darfur, Sudan." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-115437.

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Ziele der Arbeit sind die Bestimmung der dominanten Landnutzungsarten im Untersuchungsgebiet von Edd Al Fursan (Sudan) sowie die Kartierung und Analyse der Veränderungen der Landnutzung im Zeitraum 1972 bis 2008 mit Hilfe von multi-temporalen Satellitenbildern (Landsat MSS, TM und ETM sowie Terra ASTER). Des weiteren erfolgt eine Evaluierung des Einflusses von Veränderungen der Landnutzung auf die Lebensbedingungen der ländlichen Bevölkerung in Hinblick auf die Verfügbarkeit von Ressourcen mit Hilfe von quantitativen Untersuchungsmethoden. Um diese Aussagen treffen zu können, werden drei Methoden der Bestimmung von Veränderungen der Landnutzung angewandt, und zwar Post Classification Comparison (PCC), Change Vector Analysis (CVA) basierend auf Tasseled Cap Transformation (TCT) sowie Iteratively Reweighted Multivariate Alteration Detection (IR-MAD) mittels Maximum Autocorrelation Factor (MAF). Neben den fernerkundlichen Untersuchungen wurde eine sozio-ökonomische Feldstudie durchgeführt, die vorstrukturierte Fragenkataloge, Interviews und Gruppendiskussionen mit Personen in regionalen und lokalen Schlüsselpositionen und mit älteren Menschen durchgeführt. Fünf Klassen der Landnutzung und Landbedeckung ergeben sich aus einer Klassifikation der Satellitenbilder mit der Methode der größten Wahrscheinlichkeit (Maximum Likelihood), explizit die Klassen Grasland, Waldland, Brachland, bebautes und landwirtschaftlich nicht genutztes Land. Die Klassifikation schafft eine genaue Grundlage für die Kartierung, Quantifizierung und Analyse der Änderungen. Die Gesamtgenauigkeit der Flächenermittlung beträgt 83% für die Jahre 1972 und 1984, 85% für 1989, 87% für 1999 und 92% für 2008. Die Untersuchungen zeigen, dass die Post Classification Comparison (PCC) eine vollinhaltlich geeignete und leicht anzuwendende Methode der Flächenanalyse darstellt. Change Vector Analysis (CVA) beruhend auf Tasseled Cap Transformation (TCT) wird ebenfalls für die Kartierung und Bestimmung von Landnutzungsänderungen verwendet. Durch TCT wird der spektrale Bildinhalt in die Komponenten Greeness und Brightness transformiert sowie in dem dadurch neu definierten Koordinatensystem die CVA durchgeführt. Die Ergebnisse in Form von Vektoren der Veränderung mit messbarer Richtung und messbarem Ausmass der Flächendynamik beweisen, dass die Methode für die Kartierung von Vegetationsbedeckung und insbesondere von Entwaldung und Wiederbewaldung geeignet ist. Durch die Anwendung der Multivariate Alteration Detection (MAD) in Kombination mit dem Maximum Autocorrelation Factor (MAF) werden Veränderungen der Landnutzungsklassen während des betrachteten Zeitraumes visualisiert. Die Ergebnisse beweisen, dass die MAD für die Veränderungsanalyse in multi-spektralen Satellitenbildern sehr gut geeignet ist. Darüber hinaus wird nachgewiesen, dass die Kombination mit dem MAF die Ergebnisse der MAD entscheidend verbessern kann, da Rauschen und geringfügige Änderungen unterdrückt und signifikante Änderungen klarer herausgestellt und damit besser interpretierbar werden. Um die Ursachen für die Veränderungen der Landnutzung und den Einfluss dieser Änderungen auf die Lebensbedingungen der ländlichen Bevölkerung im Projektgebiet zu identifizieren, wurde eine Befragung mittels vorstrukturiertem Fragenkatalog, Interviews und Gruppengesprächen mit 100 GesprächspartnerInnen im Alter zwischen 42 und 65 Jahren in vier nach dem Zufallsprinizip ausgewählten Dörfern ausgeführt. Die Auswertung der sozio-ökonomischen Daten erlaubt die Extraktion der Faktoren, die Landnutzung und deren Änderung beeinflussen, und die zu bestimmten Auswirkungen dieser Änderungen auf die Lebensbedingungen in den Dörfern in Hinsicht auf die Verfügbarkeit von Natur-Ressourcen führen. Die Ergebnisse der Forschungsarbeiten zeigen, dass Fernerkundung und sozio-ökonomische Datenanalyse effizient verknüpft werden können, um anthropogene Einflüsse auf Art und Dynamik von Landnutzung sichtbar zu machen. In bezug auf die gegenständliche Zeitreihe wird durch die Untersuchungen bewiesen, dass zunehmende Bevölkerungszahlen im Gebiet von Edd Al-Fursan in direktem Wirkungszusammenhang mit Veränderungen der Landnutzung stehen.

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Valdau, Olga Verfasser], Dieter [Akademischer Betreuer] [Willbold, and J. [Akademischer Betreuer] Bode. "Untersuchungen zur Rekonstruktion von c-Src-NS5A-NS5B sowie EDD E3-β-Catenin – zweier krankheitsrelevanter Proteinkomplexe / Olga Valdau. Gutachter: Dieter Willbold ; J. Bode." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1077866798/34.

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Valdau, Olga [Verfasser], Dieter [Akademischer Betreuer] Willbold, and J. [Akademischer Betreuer] Bode. "Untersuchungen zur Rekonstruktion von c-Src-NS5A-NS5B sowie EDD E3-β-Catenin – zweier krankheitsrelevanter Proteinkomplexe / Olga Valdau. Gutachter: Dieter Willbold ; J. Bode." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1077866798/34.

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Aldridge, Danielle V. "Leadership and management behaviors of the deans of student services within the Los Angeles Community College District /." Pepperdine University, Dissertation (EdD), 1997.

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Böhmer, Heiner. "Barbara Wehr / Frédéric Nicolosi (edd.), Pragmatique historique et syntaxe. Actes de la section du même nom du XXXIe Romanistentag allemand (Bonn, 27. 9. – 1. 10. 2009)." De Gruyter, 2013. https://tud.qucosa.de/id/qucosa%3A71158.

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In dem seit Herbst 2012 vorliegenden Band, der von der Mainzer Italianistin und Franko-Romanistin Barbara Wehr und einem Mitarbeiter (Frédéric Nicolosi) herausgegeben wurde, sind 14 Beiträge versammelt, die zwei hauptsächliche Forschungsinteressen bedienen: Einerseits wird in allen Aufsätzen ganz allgemein erprobt, wie sich die pragmatisch orientierte und die strukturell bestimmte historische Syntaxanalyse gegenseitig befruchten können, um genaue Beschreibungen formaler Eigenschaften mit differenzierten funktionalen Erörterungen zu verbinden; andererseits liegt das Gros der Artikel des Bandes in der Linie der Erforschung eines ganz bestimmten Teilthemas, nämlich von Strukturen, die in den älteren Sprachstufen des Romanischen Topic und Fokus markierten, vor allem Spaltsätze und Verlagerungen von Wortgruppen mit oder ohne pronominale Spur.

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Nguyen, Viet Hung. "Analyse d'oligonucléotides par bombardement d'électrons rapides." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00833409.

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L'objectif de ma thèse est d'étudier des oligonucléotides et mononucléotides par de nouvelles techniques de fragmentation comme l'EDD (Electron-Detachment-Dissociation) et l'EID (Electron-Induced-Dissociation) qui font intervenir un bombardement d'électrons. Les échantillons sont d'abord ionisés par une source electrospray (ESI) qui permet une ionisation douce. Au cours de mon travail de thèse, je me suis intéressé à l'étude de petits oligonucléotides (ADN et ARN simples brins) et de mononucléotides par EDD et EID. Tout d'abord nous optimisons les différents paramètres qui ont permis d'obtenir en ESI les espèces multichargées pour étudier les processus EDD, EID d'oligonucléotides à des états de charge différents, afin d'obtenir le maximum d'ions fragments. Ces spectres seront comparés avec les spectres SORI-CID (Collision-Induced-Dissociation) et IRMPD (Infrared-Multiphoton-Dissociation) pour mettre en évidence les spécificités de l'EDD et EID par rapport au SORI-CID. Les spectres EDD et EID montrent quelques ions fragments qui ne sont pas observés dans les spectres SORI-CID et IRMPD parce que ces derniers ne conduisent pas aux ions radicalaires. Grâce aux ions fragments radicalaires obtenus en EDD et en EID, nous avons pu accéder au séquençage d'oligonucléotides riches en thymine pour lesquels il est difficile d'obtenir des informations par les méthodes conventionnelles. Enfin nous avons utilisé des techniques particulières de la technologie ICR et qui seront présentées dans ce manuscrit

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Bashir, Masarra Ahmed Adam [Verfasser], Elmar [Akademischer Betreuer] Csaplovics, and Ali Taha [Akademischer Betreuer] Ayoub. "The Impact of Land-use change on the Livelihoods of Rural Communities: A case-study in Edd Al-Fursan Locality, South Darfur, Sudan / Masarra Bashir. Gutachter: Elmar Csaplovics ; Ali Taha Ayoub. Betreuer: Elmar Csaplovics." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://d-nb.info/1068152834/34.

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Taylor, Rowena Margaret. "Teachers' conflicting responses to change: an evaluation of the implementation of senior social studies for the NCEA, 2002-2006 : a thesis presented in partial fulfilment of the degree of Doctor of Education (EdD), Massey University, Palmerston North, New Zealand." Massey University, 2008. http://hdl.handle.net/10179/1023.

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The thesis provides a socio-historical perspective through which to evaluate the first five years of implementation (2002 to 2006) of social studies within the National Certificate of Educational Achievement [NCEA] in New Zealand secondary schools. The experiences of both lead educators, with responsibilities at a national level, and classroom teachers provide insights into the personal, contextual and institutional factors which have enabled and constrained the implementation process, especially at NCEA level one. The inclusion of social studies as a subject for the new qualifications and assessment system in New Zealand, the NCEA, heralded a significant opportunity for this integrated subject to gain academic status and acquire a unique identity within the senior secondary school curriculum. Paradoxically it set a relatively strongly framed assessment system beside a curriculum that has traditionally been weakly classified and framed (Bernstein, 1971). This paradox has created tensions for teachers who have responded in different ways, from full implementation to a more functional approach. Two groups of teachers were identified in the course of this study. The idealists are passionate advocates for senior social studies and are likely to implement it to all three NCEA levels in their school. The pragmatists, on the other hand, are more likely to offer only level one social studies, typically to their more academically able year 10 (Form 4) students for extension purposes, and also to induct them into the assessment requirements of the NCEA system before they study the traditional social science subjects at levels one, two and three. This pragmatic approach reflects past practices of the pre- NCEA, School Certificate era (1945-2001). It continues to reinforce the low status and unclear identity of senior social studies within the social sciences as well as within an already overcrowded senior school curriculum. At the end of this first five year period of implementation the viability of senior social studies is at a critical juncture, with its on-going success not yet assured.

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Bayen, Térence. "Etude de quelques problèmes de contrôle optimal issus des EDP et des EDO." Habilitation à diriger des recherches, Université Montpellier II - Sciences et Techniques du Languedoc, 2013. http://tel.archives-ouvertes.fr/tel-00919030.

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Le premier chapitre de ce mémoire porte sur l'étude des minimum forts pour des problèmes de contrôle optimal gouvernés par des EDP semi-linéaires elliptiques et paraboliques avec contraintes intégrales sur l'état final. Le second chapitre porte sur l'étude du problème de temps minimal pour un système de type chemostat en présence de points singuliers stationnaires. On y étudie également un problème de contrôle optimal pour un système chemostat avec deux espèces en compétition et qui comporte une courbe de non-contrôlabilité. Le troisième chapitre s'intéresse à la synthèse d'un contrôle optimal par retour d'état pour un problème de temps minimal issu d'un système fed-batch, notamment en présence d'un contrôle impulsionnel. Le quatrième chapitre étudie deux problèmes de contrôle optimal sous contraintes d'état périodiques. Enfin, le dernier chapitre traite de problèmes d'optimisation de forme géométriques sous contraintes de convexité. Cette dernière est formulée comme une contrainte semi-définie, ce qui permet ensuite d'utiliser la programmation SDP pour minimiser la fonction coût.

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Beya, Ouadi. "Analyse et reconnaissance de signaux vibratoires : contribution au traitement et à l'analyse de signaux cardiaques pour la télémédecine." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS015/document.

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Le coeur est un muscle. Son fonctionnement mécanique est celui d'une pompe chargée de distribuer et de récupérer le sang dans les poumons et dans le système cardiovasculaire. Son fonctionnement électrique est régulé par le son noeud sinusal, un stimulateur ou régulateur électrique chargé de déclencher les battements naturels du coeur qui rythment le fonctionnement du corps. Les médecins surveillent ce fonctionnement électromécanique du coeur en enregistrant un signal électrique appelé électrocardiogramme (ECG) ou un signal sonore : le phono-cardiogramme (PCG). L'analyse et le traitement de ces deux signaux sont fondamentaux pour établir un diagnostic et aider à déceler des anomalies et des pathologies cardiaques. L’objectif de cette thèse est de développer des techniques de traitement des signaux ECG et notamment PCG afin d’aider le médecin dans son analyse de ces signaux. L’idée de fond est de mettre en point des algorithmes relativement simples et peu coûteux en temps de calcul. Le premier intérêt serait de garantir leur implantation aisée dans un système mobile de surveillance cardiaque à l’usage du médecin, voire du patient. Le deuxième intérêt réside dans la possibilité d’une analyse automatique en temps réel des signaux avec le dispositif mobile, autorisant le choix de la transmission de ces signaux pour une levée de doute. De nombreux travaux ont mené à des avancées significatives dans l’analyse des signaux ECG et la reconnaissance automatiques des pathologies cardiaques. Des bases de données de signaux réels ou synthétiques annotées permettent également d’évaluer les performances de toute nouvelle méthode. Quant aux signaux PCG, ils sont nettement moins étudiés, difficiles à analyser et à interpréter. Même si les grandes familles de méthodes (Fourier, Wigner Ville et ondelettes) ont été testées, elles n’autorisent pas une reconnaissance automatique des signatures, d’en avoir une analyse et une compréhension assez fines.La Transformée en Ondelettes (TO) sur les signaux cardiaques a montré son efficacité pour filtrer et localiser les informations utiles mais elle fait intervenir une fonction externe de traitement (ondelette mère) dont le choix dépend de la connaissance au préalable du signal à traiter. Ce n'est pas toujours adapté aux signaux cardiaques. De plus, la Transformée en ondelettes induit généralement une imprécision dans la localisation due à la fonction externe et éventuellement au sous-échantillonnage des signatures. La nature non stationnaire de l'ECG et du PCG et leur sensibilité aux bruits rendent difficile la séparation d’une transition informative d'une transition due aux bruits de mesure. Le choix de l'outil de traitement doit permettre un débruitage et une analyse de ces signaux sans délocalisation des singularités ni altération de leurs caractéristiques. En réponse à nos objectifs et considérant ces différents problèmes, nous proposons de nous appuyer principalement sur la décomposition modale empirique (EMD) ou transformée de Hilbert Huang (THH) pour développer des solutions. L’EMD est une approche non linéaire capable de décomposer le signal étudié en fonctions modales intrinsèques (IMF), oscillations du type FM-AM, donnant ainsi une représentation temps/échelle du signal. Associée à la transformée de Hilbert (TH), la THH permet de déterminer les amplitudes instantanées (AI) et les fréquences instantanées (FI) de chaque mode, menant ainsi à une représentation temps/fréquence des signaux.Sans faire intervenir une fonction externe, on peut ainsi restaurer (réduction de bruit), analyser et reconstruire le signal sans délocalisation de ses singularités. Cette approche permet de localiser les pics R de l'ECG, déterminer le rythme cardiaque et étudier la variabilité fréquentielle cardiaque (VFC), localiser et analyser les composantes des bruits B1 et B2 du PCG
The heart is a muscle. Its mechanical operation is like a pump charged for distributing and retrieving the blood in the lungs and cardiovascular system. Its electrical operation is regulated by the sinus node, a pacemaker or electric regulator responsible for triggering the natural heart beats that punctuate the functioning of the body.Doctors monitor the electromechanical functioning of the heart by recording an electrical signal called an electrocardiogram (ECG) or an audible signal : the phonocardiogram (PCG). The analysis and processing of these two signals are essential for diagnosis, to help detect anomalies and cardiac pathologies.The objective of this thesis is to develop signal processing tools on ECG and PCG to assist cardiologist in his analysis of these signals. The basic idea is to develop algorithms of low complexity and having inexpensive computing time. The primary interest is to ensure their easy implementation in a mobile heart monitoring system for use by the doctor or the patient. The second advantage lies in the possibility of automatic real-time analysis of signals with the mobile device, allowing control of the transmission of these signals to a removal of doubt.Numerous studies have led to significant advances in the analysis of ECG signals and the automatic recognition of cardiac conditions. Databases of real or synthetic signals annotated also assess the performance of new methods. PCG signals are much less studied, difficult to analyze and to interpret. The main methods (Fourier, wavelet and Wigner Ville) were tested : they do not allow automatic recognition of signatures, and an accurate understanding of their contents.Wavelet Transform (WT) on cardiac signals showed its effectiveness to filter and locate useful information, but it involves an external processing function (mother wavelet) whose the choice depends on the prior knowledge on the signal to be processed. This is not always suitable for cardiac signals. Moreover, the wavelet transform generally induces inaccuracies in the location due to the external function and optionally due to the sub- sampling of the signatures.The non-stationary nature of the ECG and PCG and their sensitivity to noise makes it difficult to separate an informative transition of a transition due to measurement noise. The choice of treatment tool should allow denoising and analysis of these signals without alteration or the processing tool delocalization of the singularities.In response to our objectives and considering these problems, we propose to rely primarily on empirical mode decomposition (EMD) and Hilbert Huang Transform (HHT) to develop solutions. The EMD is a non linear approach decomposing the signal in intrinsic signal (IMF), oscillations of the type FM-AM, giving a time/scale signal representation. Associated with the Hilbert transform (TH), the THH determines the instantaneous amplitude (IA) and instantaneous frequency (IF) of each mode, leading to a time/frequency representation of the ECG and PCG.Without involving an external function, EMD approach can restore (noise reduction), analyze and reconstruct the signal without relocation of its singularities. This approach allows to locate R peaks of the ECG, heart rate and study the cardiac frequency variability (CFV), locate and analyze the sound components B1 and B2 of the PCG.Among the trials and developments that we made, we present in particular a new method (EDA : empirical denoising approach) inspired by the EMD approach for denoising cardiac signals. We also set out the implementation of two approaches for locating ECG signature (QRS complex, T and P waves). The first is based on the detection of local maxima : in using Modulus Maxima and Lipschitz exponent followed by a classifier. The second uses NFLS, wich an nonlinear approach for the detection and location of unique transitions in the discrete domain

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Rochol, Juergen. "Caracterização e conformação de fluxos de tráfego ATM no ambiente de usuário." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2001. http://hdl.handle.net/10183/118430.

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Apresenta-se um framework que permite a caracterização, conformação e escalonamento de todas as categorias de serviços A TM, dentro do ambiente de usuário (CEP). Propõem-se um modelo de tráfego otimizado para este ambiente que oferece condições de garantias de QoS individuais para fluxos VBR, tempo real ou não, CBR, ABR e UBR. O modelo proposto, denominado de PCSTS (priority class services traffic shaping), inclui um módulo que permite a obtenção do descritor de tráfego de fluxos desconhecidos. Os fluxos são conformados de forma individual, e em tempo real, segundo um conformador baseado num algoritmo de escalonamento virtual duplo baseado no GCRA do ITU/ ATM Forum. Para a multiplexação dinâmica dos diferentes fluxos do ambiente de usuário, no enlace de acesso, é proposto um algoritmo de escalonamento EDD, modificado através de um sinal de realimentação entre conformador e escalonador, e desta forma tem-se condições de oferecer garantias de limite de atraso e jitter para fluxos individuais de serviços rt-VBR ou nrt-VBR. São apresentadas simulações, tanto da caracterização dos fluxos desconhecidos como da arquitetura do escalonador, que comprovam o comportamento esperado do modelo de tráfego PCSTS.
We present a framework that enhances the characterization, shaping and scheduling of ATM traffic flows for ali ATM service categories in the customer prernise equipment (CPE) environment. We propose an optirnized traffic model, capable to guarantee QoS parameters at per connection levei for VBR services, real time or not, CBR, ABR and UBR services. The model proposed, narned PCSTS (priority classes services traffic shaping), includes a module that performs the characterization of services with unknown traffic descriptor. The flows are shaped individually, in real time, through a shaper based on the double discrete time scheduling algorithm of the GCRA from ITU/ ATM Forum. For the dynarnic multiplexing of the different service flows , at the link levei, a modified EDD scheduling algorithm is proposed with a feedback signal between the scheduling and shaping modules. As a result, it is demonstrated that it is possible to grant jitter and delay bounds for the rt-VBR and nrt-VBR services. We present simulations of the traffic characterization module and of the scheduling architecture, for different services, which confirms the expected behavior of the PCSTS model.

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Fahlaoui, Tarik. "Réduction de modèles et apprentissage de solutions spatio-temporelles paramétrées à partir de données : application à des couplages EDP-EDO." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2535.

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On s’intéresse dans cette thèse à l’apprentissage d’un modèle réduit précis et stable, à partir de données correspondant à la solution d’une équation aux dérivées partielles (EDP), et générées par un solveur haute fidélité (HF). Pour ce faire, on utilise la méthode Dynamic Mode Decomposition (DMD) ainsi que la méthode de réduction Proper Orthogonal Decomposition (POD). Le modèle réduit appris est facilement interprétable, et par une analyse spectrale a posteriori de ce modèle on peut détecter les anomalies lors de la phase d’apprentissage. Les extensions au cas de couplage EDP-EDO, ainsi qu’au cas d’EDP d’ordre deux en temps sont présentées. L’apprentissage d’un modèle réduit dans le cas d’un système dynamique contrôlé par commutation, où la règle de contrôle est apprise à l’aide d’un réseau de neurones artificiel (ANN), est également traité. Un inconvénient de la réduction POD, est la difficile interprétation de la représentation basse dimension. On proposera alors l’utilisation de la méthode Empirical Interpolation Method (EIM). La représentation basse dimension est alors intelligible, et consiste en une restriction de la solution en des points sélectionnés. Cette approche sera ensuite étendue au cas d’EDP dépendant d’un paramètre, et où l’algorithme Kernel Ridge Regression (KRR) nous permettra d’apprendre la variété solution. Ainsi, on présentera l’apprentissage d’un modèle réduit paramétré. L’extension au cas de données bruitées ou bien au cas d’EDP d’évolution non linéaire est présentée en ouverture
In this thesis, an algorithm for learning an accurate reduced order model from data generated by a high fidelity solver (HF solver) is proposed. To achieve this goal, we use both Dynamic Mode Decomposition (DMD) and Proper Orthogonal Decomposition (POD). Anomaly detection, during the learning process, can be easily done by performing an a posteriori spectral analysis on the reduced order model learnt. Several extensions are presented to make the method as general as possible. Thus, we handle the case of coupled ODE/PDE systems or the case of second order hyperbolic equations. The method is also extended to the case of switched control systems, where the switching rule is learnt by using an Artificial Neural Network (ANN). The reduced order model learnt allows to predict time evolution of the POD coefficients. However, the POD coefficients have no interpretable meaning. To tackle this issue, we propose an interpretable reduction method using the Empirical Interpolation Method (EIM). This reduction method is then adapted to the case of third-order tensors, and combining with the Kernel Ridge Regression (KRR) we can learn the solution manifold in the case of parametrized PDEs. In this way, we can learn a parametrized reduced order model. The case of non-linear PDEs or disturbed data is finally presented in the opening

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Boman, Maria. "XML/EDI - EDI med XML-format?" Thesis, University of Skövde, Department of Computer Science, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-422.

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Electronic data interchange (EDI) är en teknik vilken används för att utbyta elektroniska dokument mellan köpare och säljare. Dessa dokument överförs på en strikt elektronisk standardiserad väg, dokumenten kan vara fakturor, beställningsformulär, leveransplaner etc. EDI har funnits i över 25år och är vida spridd över världen. För att använda EDI krävs det stora resurser i form av kapital och kunskap. Små och medelstora företag har ofta inte de resurser som krävs för att kunna använda EDI.

Nya tekniker utvecklas ständigt. Extensibel Markup Language (XML) är en ny teknik vilken är avsedd att användas främst på Internet. XML delar upp dokumenten med hjälp av etiketter vilket hjälper läsaren att identifiera innehållet i dokumenten. XML har väckt EDI-samhällets intresse då XML anses ha kapaciteten att kunna användas som ett EDI-format samtidigt som XML är Internetanpassat vilket betyder att EDI enklare skulle kunna användas på Internet.

I mitt examensarbete har jag utrett om EDI-användande företag avser använda XML/EDI. Jag har genomfört intervjuer för att besvara problemformuleringen. Resultaten jag kommit fram till är att företagen avser använda XML/EDI om en ordentlig standard blir framtagen. Företagen är dessutom positivt inställda till XML/EDI samt Internetbaserad EDI. Anledningen till den positiva inställningen är främst att XML/EDI samt Internetbaserad EDI skulle innebära lägre kostnader vilket i sin tur skulle innebära att även små och medelstora företag skulle kunna använda tekniken.

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Rokotianskaia, Kseniia. "Facelift EDU." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414282.

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The subject of the diploma thesis is the elaboration of an architectural study of the reconstruction of the pre-plant zone of the Facelift of the Dukovany power plant. The construction site is an area that belongs to the village of Dukovany and borders the village of Rouchovany. As a whole, this area is in poor technical and architectural condition. However, its location gives potential for new uses. The solved area belongs to the ČEZ nuclear power plant.

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Růžičková, Tereza. "Facelift EDU." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414284.

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The theme of the diploma thesis is the solution of the pre-plant zone of the Dukovany nuclear power station. Creating a vision of how this space could develop further in the next 50 years and how it could work in a transitional phase during the construction of a new nuclear power plant unit. The subject of the thesis is the elaboration of an architectural study, which is based on an urban study. Urban study was processed within the framework of the pre-diploma thesis and solved mainly the overall problems of this area, the new transport connection, and the functional division of the whole area. The area was divided into three functional units, namely the transport zone, the administrative zone and the sports and education zone. At present, there are a lot of small structurally and functionally unsuitable buildings in this area. The diploma thesis deals with the design of new buildings with a clear functional use in the administrative zone, in the area in front of the main gatehouse. A new representative square was created, and three buildings are designed around it. The dominant feature of the whole area was a high-rise office building near the gatehouse. In front of the office building, towards the main road, the service building I was designed, which contains business and healthcare services. On the other side of the square was located the service building II, where there are technical services, such as workshops, warehouses and metrology. The last building solved within the diploma thesis is the building of sports and locker rooms of suppliers, which is designed behind the square near the greenery. New building copies mass of the only preserved building in this area, namely the building of the information centre. The designed building has a fitness centre and locker rooms of external workers of the power plant.

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Sobotková, Monika. "Facelift EDU." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414287.

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The master thesis deals with the facelift of the forecourt of the Dukovany Nuclear Power Station . This space consists of supporting functions for the main working such as administrative, metrology, stocks, cloakrooms and services. There is also the station for the buses, which carry employees to and from work, the regular bus station and parking lots. The forecourt of the power station is now inconvenient from a functional point of view, because the capacity of the existing buildings and parking lots is insufficient; and also from aesthetic point of view, because the buildings from 70’s don’t look good anymore, the parking consists of the large asphalt areas and there is no representative anteroom in front of the main entry, which should be there in view of the significance of the power station. In the study I deal with these problems by the complex reconstruction of the area, I replace the huge asphalt parking lots with the parking houses, create the administrative zone with the public place in front of the main entry to the plant, extend the capacities for the particular functions and add the new required functions (kindergaten, other services). The result of this conversion is the area with the particular functional zones with the representative forecourt in front of the main entry and with the enough space for each of the functions. This work follows up the last semester urbanist-architectonic study. The diploma thesis focus on the improvements of the weaker parts of the prime study and on the elaboration of the architectural study of the adminstrative zone with services.

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Tomoryová, Bianka. "Facelift EDU." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414291.

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The subject of the diploma thesis is an architectural study of the forecourt of the Dukovany Nuclear Power Station. The project is based on a pre-diploma project which aimed to develop an urban concept. At the moment the buildings in the area are in an unsuitable condition from a construction - technical and architectural perspective. The urban-architectural study was intended to create a new concept for the forecourt and simultaneously enable its efficient operation in case of the completion of a new nuclear unit. The concept of the solution is based on the removal of outdated buildings and their replacement with new buildings which will meet the current requirements of the Dukovany Nuclear Power Station. From the current layout the main roads, the gatehouse, the information center and the greenery will be preserved. After removing the selected buildings, the renovation area will be divided into the main axes on which the main road network will be designed. The unsuitable connection to public road infrastructure will be solved by minimizing the entrances to the area to two entrances and by moving the suburban bus station from the main road. After connecting the whole area by roads, the area will be divided into functional areas. In front of the gatehouse there will be a square surrounded by public services, an administrative building and by the preserved information center building. From this space, the main representative space of the entire complex will be created. Warehouses and workshops will be located behind the square. Transport areas will be located at the rear of the complex. Thanks to this location, there will be a good connection with the current factory and also with the planned completion of the new nuclear unit on the west of the area. There will also be educational and sport facilities in the complex. The kindergarten will be oriented towards the preserved greenery.

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Zhakupbekova, Rakhil. "Facelift EDU." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414302.

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The subject of the diploma thesis is the elaboration of an architectural study of the reconstruction of the pre-plant zone of the Facelift of the Dukovany power plant. The construction site is an area that belongs to the village of Dukovany and borders the village of Rouchovany. As a whole, this area is in poor technical and architectural condition. However, its location gives potential for new uses. The solved area belongs to the ČEZ nuclear power plant.

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Strömberg, Malin, and Frida Holmberg. "Edu-Care." Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-29030.

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Syftet med vår studie är att undersöka hur förskollärare ser på innebörden av begreppen undervisning och omsorg i förskolans verksamhet. Uppsatsen baseras på frågorna:-Hur beskriver pedagogerna vad undervisning är?-Hur beskriver pedagogerna vad omsorg är?-Hur förklarar pedagogerna relationen mellan undervisning och omsorg? -Hur redogör pedagogerna för fördelar respektive nackdelar med en mer skolinriktad förskola?Metoden vi använt för denna studie är intervjuer med pedagoger från olika avdelningar på en och samma förskola. Arbetets tidigare forskning och teoridel förklaras bland annat utifrån John Bowlby och Mary Ainsworths forskning kring anknytning, Lev S Vygotskijs forskning om språk och sociala samspel samt nationella forskare, som till exempel Ingrid Pramling Samuelsson, Sonja Sheridan och Sven Persson. I delen resultat och analys sammanfattar och förklarar vi vår empiri med hjälp av teori och forskning. Begreppen undervisning och omsorg förklaras var för sig för att avslutningsvis knytas samman till en helhet. Slutsatsen av vår studie visar att det spänningsfält som vi först upplevde fanns mellan undervisning och omsorg egentligen inte finns. Efter vår analys av empirin har vi insett att problematiken och spänningsfältet istället ligger mellan begreppen undervisning och lärande. Resultatet visar på att undervisning och omsorg går hand i hand i den verksamhet vi undersökt. Däremot så upplevs undervisning som ett laddat begrepp som hellre ersätts med begreppet lärande när det handlar om förskolan.

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Zhou, Li. "Problèmes Statistiques pour les EDS et les EDS Rétrogrades." Phd thesis, Université du Maine, 2013. http://tel.archives-ouvertes.fr/tel-00808623.

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Nous considérons deux problèmes. Le premier est la construction des tests d'ajustement (goodness-of-fit) pour les modèles de processus de diffusion ergodique. Nous considérons d'abord le cas où le processus sous l'hypothèse nulle appartient à une famille paramétrique. Nous étudions les tests de type Cramer-von Mises et Kolmogorov- Smirnov. Le paramètre inconnu est estimé par l'estimateur de maximum de vraisemblance ou l'estimateur de distance minimale. Nous construisons alors les tests basés sur l'estimateur du temps local de la densité invariante, et sur la fonction de répartition empirique. Nous montrons alors que les statistiques de ces deux types de test convergent tous vers des limites qui ne dépendent pas du paramètre inconnu. Par conséquent, ces tests sont appelés asymptotically parameter free. Ensuite, nous considérons l'hypothèse simple. Nous étudions donc le test du khi-deux. Nous montrons que la limite de la statistique ne dépend pas de la dérive, ainsi on dit que le test est asymptotically distribution free. Par ailleurs, nous étudions également la puissance du test du khi-deux. En outre, ces tests sont consistants. Nous traitons ensuite le deuxième problème : l'approximation des équations différentielles stochastiques rétrogrades. Supposons que l'on observe un processus de diffusion satisfaisant à une équation différentielle stochastique, où la dérive dépend du paramètre inconnu. Nous estimons premièrement le paramètre inconnu et après nous construisons un couple de processus tel que la valeur finale de l'un est une fonction de la valeur finale du processus de diffusion donné. Par la suite, nous montrons que, lorsque le coefficient de diffusion est petit, le couple de processus se rapproche de la solution d'une équations différentielles stochastiques rétrograde. A la fin, nous prouvons que cette approximation est asymptotiquement efficace.

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Fernandes, Ana Fragoso. "EDP Energias de Portugal: electric utilities: EDP- Back foot." Master's thesis, NSBE - UNL, 2011. http://hdl.handle.net/10362/10440.

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Leininger-Frézal, Caroline. "Le développement durable et ses enjeux éducatifs. Acteurs, savoirs et stratégies territoriales." Phd thesis, Université Lumière - Lyon II, 2009. http://tel.archives-ouvertes.fr/tel-00449803.

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Le développement durable et l'éducation qui lui est affiliée, sont aujourd'hui des questions socialement vives. Ces questions sont au cœur de nombreuses initiatives qu'elles soient politiques ou non. Les nombreux acteurs mobilisés sur le sujet sont d'origine diverse. L'Etat bien sur, et ses services déconcentrés se sont engagés mais également des collectivités territoriales, des institutions publiques ou parapubliques, l'Ecole et les associations d'éducation non formelle ou de protection de l'environnement. La diversité et la multiplicité des actions menées interrogent leur cohérence. Cette recherche doctorale propose un tableau des pratiques actuelles en éducation relative à l'environnement et/ou au développement durable. Elle analyse la place des parties prenantes, les enjeux sous-jacents et leurs stratégies territoriales. C'est aussi un regard critique sur les savoirs qui structurent aujourd'hui le champ.

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Cederqvist, Helene, and Björn Nilsson. "Effekter av EDI." Thesis, Linköping University, Department of Management and Economics, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-664.

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Background: It has been shown that EDI can yield positive effects within companies. Which effects are possible for a company to direct assign to the introduction of EDI and is it possible to estimate the total effect.

Purpose: The purpose of this study is to estimate and analyze the effects of using EDI in electronic business. We also want to contribute with a model for measure and estimate the effects of EDI.

Accomplishment: We have studied literature concering EDI and realized a preliminary studie in form of interviews with experts to establish deeper knowledge of EDI. We have also tried to estimate the effects obtained in companies in three different businesses, power, government and transport industry.

Result: To obtain as good effects as possible it is important that the co- oporation is built on trust and engagement. Before implementing the EDI-system a thorough overhaul of the processes in the company should be done, involving both the top managers and the staff. Internet can be used to achieve minimal cost and it is important to limit the information sent by EDI to only send the information demanded. Finally companies also should mediate the advantages of EDI inside the organisation to make the co-operators realize the good effects obtained by EDI.

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Venclová, Miroslava. "Divadlo jednoho Edy." Master's thesis, Akademie múzických umění v Praze. Divadelní fakulta AMU. Knihovna, 2007. http://www.nusl.cz/ntk/nusl-78599.

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This work concerns with The theatre of One Eda, it talks about the history of this one-woman show, about the creation of performances and about each individual puppet performance for children. Because the tradition of the puppet theatre in the Czech Republic is very strong, the author of this work is trying to answer the question what exactly is the puppet theatre. She also concentrates on a very brief summary of the history of the puppet theatre across the Czech Republic. The first part contains the characteristic of fairy tale, its function - that all is examined with consideration of the children?s viewer. In the second part the author writes about the history of The theatre of one Eda, about the creation of performances. Reactions of different audience are being compared and hold forth in this part. In conclusion there are compared commonly known facts introduced in the first part of this work with information gained by an actress of The theatre of one Eda.

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Braglia, Israel de Alcântara. "Design para EAD." reponame:Repositório Institucional da UFSC, 2013. http://repositorio.ufsc.br/handle/123456789/103287.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Design e Expressão Gráfica, Florianópolis, 2010
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A educação de caráter não presencial tem se apropriado das tecnologias de informação e comunicação e se expandido em todo mundo. Nesse contexto, destaca-se a relação entre design instrucional e design gráfico, que a partir da elaboração de conteúdos e produtos aplicados as mídias impressas e digitais apresenta potencialidades para o nicho de Educação a Distância. - EAD. O Design Gráfico, sobretudo, a partir das funções de informação e persuasão, age como o elo articulador entre o aluno e o educador a distância. Desse modo, esta pesquisa, caracterizada como um estudo de caso, desenvolveu-se a partir de um método subdividido em quatro principais etapas, a saber: revisão da literatura, estudo de caso, discussão e conclusão. No estudo de caso, acompanhou-se as ações de design no contexto de concepção e implementação de uma disciplina de um MBA, de uma Instituição Privada, no período de novembro de 2008 a março de 2009. Foram detalhadas as etapas, as decisões projetuais e os resultados. Ao aprofundar a combinação entre o design gráfico e o design instrucional e apontar as especificidades que dão suporte ao desenvolvimento de materiais instrucionais, construção de hipermídias para a educação e implementação de cursos a distância, ressalta-se que as ações de design gráfico devem ocorrer de forma integrada e sistemática. As ações de design provindas da relação entre o design instrucional e o design gráfico são resultados do planejamento de mídias integradas.

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Pimenta, João Pedro Fragoso. "EDP: dynamic pillar." Master's thesis, NSBE - UNL, 2011. http://hdl.handle.net/10362/10444.

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Santamaria, Hernández Jair, and Mejía Vanessa López. "Disfunción de integración Sensorial en los niños escolares de 6 - 10 anos de edad, en la Escuela Primaria Ignacio Zaragoza, Metepec Edo. de Mexico mayo 2012." Tesis de Licenciatura, Medicina-Quimica, 2013. http://ri.uaemex.mx/handle/123456789/13875.

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Canli, Sedat. "Thickness Analysis Of Thin Films By Energy Dispersive X-ray Spectroscopy." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612822/index.pdf.

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EDS is a tool for quantitative and qualitative analysis of the materials. In electron microscopy, the energy of the electrons determines the depth of the region where the X-rays come from. By varying the energy of the electrons, the depth of the region where the X-rays come from can be changed. If a thin film is used as a specimen, different quantitative ratios of the elements for different electron energies can be obtained. Unique thickness of a specific film on a specific substrate gives unique energy-ratio diagram so the thickness of a thin film can be calculated by analyzing the fingerprints of the energy-ratio diagram of the EDS data obtained from the film.

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Schreiber, Alexander. "EDV-Paranoia unter Linux." Universitätsbibliothek Chemnitz, 2000. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200000549.

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Joly, Romain. "Dynamique des EDP dissipatives." Habilitation à diriger des recherches, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00908118.

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Ce mémoire comprend les chapitres : 1) Introduction 2) La généricité et les notions de "presque toujours" 3) Dynamique générique des équations paraboliques 4) Dissipativit é de l'équation des ondes amorties et application au contrôle global 5) Etude de fronts dans des EDP dissipatives

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Simao, J. M. T. B. "Electrical discharge texturing (EDT)." Thesis, University of Birmingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528899.

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Benetti, Kelly Cristina. "Competências docentes para EAD." Florianópolis, SC, 2008. http://repositorio.ufsc.br/xmlui/handle/123456789/91997.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração.
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A inserção das tecnologias da informação e comunicação na educação é uma realidade presente que vem ao encontro da concretização das políticas governamentais de expansão da educação superior no país. Para tanto, a educação a distância vem tomando proporções importantes no cenário nacional, merecendo atenção por parte da comunidade acadêmica. Os papéis exercidos por professores e alunos no processo de ensino-aprendizagem mudam e surge ainda o papel do tutor, não existente nos modelos tradicionais. Toda essa mudança exige, especialmente dos professores, um conjunto de competências específico. Neste sentido, o objetivo deste trabalho é analisar em que grau são requeridas as competências necessárias para o exercício da docência tomando como base o estudo do curso de graduação em Administração a distância da Universidade Federal de Santa Catarina. Para tanto, se desenvolveu uma pesquisa considerando como categorias de análise: competência e desenvolvimento de competências docentes. A pesquisa teve abordagem qualitativa e exploratória em sua primeira etapa e quantitativa e descritiva na segunda, caracterizando-se também como aplicada, bibliográfica e estudo de caso no projeto-piloto do referido curso. A coleta e análise de dados deram-se por meio de pesquisa documental e bibliográfica e mais especificamente entrevistas e análise do discurso na primeira etapa e aplicação de questionários e análise estatística na segunda. Percebeu-se que o estado da arte mostra-se incipiente quanto às competências específicas para atuação em EaD. Portanto foi desenvolvida a primeira etapa da pesquisa, na qual das análises das entrevistas derivou um conjunto de 32 competências divididas em competências técnicas e comportamentais. Estas foram agrupadas em três momentos de atuação do professor identificados nas entrevistas: contato com o aluno, produção de material didático e contato com o tutor. Na segunda etapa da pesquisa foi estabelecida uma escala de medição com cinco graus, com o objetivo de que os professores, tutores e alunos atribuam graus de necessidade para cada competência. De maneira geral pode-se inferir que as respostas dos alunos apresentam valores ligeiramente mais baixos, mas há coerência e homogeneidade nas respostas das três classes, demonstradas pelos baixos desvios padrão e coeficientes de variação percentual. Todas as médias atingiram graus superiores a 3, o que classifica todas as competências analisadas com graus de necessidade de médio a muito forte. Conclui-se que tanto professores como tutores e alunos tem clareza quanto ao que é requerido do docente para atuação na EaD, pois, embora hajam pequenas divergências nas médias mais elevadas em alguns grupos de competências, nota-se que essas diferenças não chegam a alcançar 1 ponto da escala utilizada.

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Carlsson, Daniel, and Daniel Snellman. "EDW på mobila enheter." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177267.

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Creating reports with a huge amount of data can be a big help when it comes to decision making, Tele2 has collected data from a lot of di erent sources and are at the moment of writing developing a system that will easily be able to produce reports and comparisons. These reports are supposed to create the foundation for better decision making and to get a better view on how the company works today. The reporting environment Cognos is adapted to use data from various sources and make it easy to take out clear reports from this. To make their work easier we have received the task of transforming these reports from only being viewable on computers to also be viewable on tablets and other mobile devices, all to make it easier to look at these reports wherever you are and whenever you want. During our work we will install and congure the mobile package that Cognos has. We will also evaluate if this is the most e ective and best way to do this. The most important part of our work is to make these reports viewable on the mobile devices and also congured so that they are easy to view and read. To achieve this we have to adapt the reports so that they no longer only are developed to read on a big screen but also to a smaller one.

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Banon, Navarro Alejandro. "Gyrokinetic large Eddy simulations." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209592.

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Le transport anormal de l’energie observé en régime turbulent joue un rôle majeur dans les propriétés de stabilite des plasmas de fusion par confinement magnétique, dans des machines comme ITER. En effet, la turbulence plasma est intimement corrélée au temps de confinement de l’energie, un point clé des recherches en fusion thermonucléaire.

Du point de vue théorique, la turbulence plasma est décrite par les équations gyrocinétiques, un ensemble d équations aux dérivées partielles non linéaires couplées. Par suite des très différentes échelles spatiales mises en jeu dans des conditions expérimentales réelles, une simulation numérique directe et complète (DNS) de la turbulence gyrocinétique est totalement hors de portée des plus puissants calculateurs actuels, de sorte que démontrer la faisabilité d’une alternative permettant de réduire l’effort numérique est primordiale. En particulier, les simulations de grandes échelles (”Large-Eddy Simulations” - LES) constituent un candidat pertinent pour permettre une telle r éduction. Les techniques LES ont initialement été développées pour les simulations de fluides turbulents à haut nombre de Reynolds. Dans ces simulations, les plus grandes échelles sont explicitement simulées numériquement, alors que l’influence des plus petites est prise en compte via un modèle implémenté dans le code.

Cette thèse présente les premiers développements de techniques LES dans le cadre des équations gyrocinétiques (GyroLES). La modélisation des plus petites échelles est basée sur des bilans d’énergie libre. En effet, l’energie libre joue un rôle important dans la théorie gyrocinétique car elle en est un invariant non lin éaire bien connu. Il est démontré que sa dynamique partage de nombreuses propriétés avec le transfert d’energie dans la turbulence fluide. En particulier, il est montré l’existence d’une cascade d énergie libre, fortement locale et dirigée des grandes échelles vers les petites, dans le plan perpendiculaire â celui du champ magnétique ambiant.

La technique GyroLES est aujourd’hui implantée dans le code GENE et a été testée avec succès pour les instabilités de gradient de température ionique (ITG), connues pour jouer un rôle crucial dans la micro-turbulence gyrocinétique. A l’aide des GyroLES, le spectre du flux de chaleur obtenu dans des simulations à très hautes résolutions est correctement reproduit, et ce avec un gain d’un facteur 20 en termes de coût numérique. Pour ces raisons, les simulations gyrocinétiques GyroLES sont potentiellement un excellent candidat pour réduire l’effort numérique des codes gyrocinétiques actuels.

/ Anomalous transport due to plasma micro-turbulence is known to play an important role in confinement properties of magnetically confined fusion plasma devices such as ITER. Indeed, plasma turbulence is strongly connected to the energy confinement time, a key issue in thermonuclear fusion research. Plasma turbulence is described by the gyrokinetic equations, a set of nonlinear partial differential equations. Due to the various scales characterizing the turbulent fluctuations in realistic experimental conditions, Direct Numerical Simulations (DNS) of gyrokinetic turbulence remain close to the computational limit of current supercomputers, so that any alternative is welcome to decrease the numerical effort. In particular, Large-Eddy Simulations (LES) are a good candidate for such a decrease. LES techniques have been devised for simulating turbulent fluids at high Reynolds number. In these simulations, the large scales are computed explicitly while the influence of the smallest scales is modeled.

In this thesis, we present for the first time the development of the LES for gyrokinetics (GyroLES). The modeling of the smallest scales is based on free energy diagnostics. Indeed, free energy plays an important role in gyrokinetic theory, since it is known to be a nonlinear invariant. It is shown that its dynamics share many properties with the energy transfer in fluid turbulence. In particular, one finds a (strongly) local, forward (from large to small scales) cascade of free energy in the plane perpendicular to the background magnetic field.

The GyroLES technique is implemented in the gyrokinetic code Gene and successfully tested for the ion temperature gradient instability (ITG), since ITG is suspected to play a crucial role in gyrokinetic micro-turbulence. Employing GyroLES, the heat flux spectra obtained from highly resolved direct numerical simulations are recovered. It is shown that the gain of GyroLES runs is 20 in terms of computational time. For this reason, Gyrokinetic Large Eddy Simulations can be considered a serious candidate to reduce the numerical cost of gyrokinetic simulations.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished

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Guerra, José António Corte-Real Garcia. "Equity research - EDP Renováveis." Master's thesis, Instituto Superior de Economia e Gestão, 2015. http://hdl.handle.net/10400.5/10529.

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Mestrado em Finanças
A EDPR é uma empresa que opera no sector da energia renovável e é hoje uma das mais importantes a trabalhar nesta área. O seu principal objectivo consiste em ser uma referência na indústria, por desenvolver, construir e operar as melhores centrais eólicas e solares no mundo. Ao contrário de muitas outras empresas que estão a ter alguns problemas com a actual conjuntura económica, a EDPR, ao investir num moderno e atractivo sector, tem conseguido ultrapassar com sucesso as dificuldades e por isso, está a construir um crescimento significativo e sólido. A elaboração deste estudo tem o propósito de obter o valor intrínseco das acções da EDPR, assente numa análise do seu desempenho operacional e do seu ambiente exógeno. O método adoptado para determinar este valor consiste no Free Cash Flow to Firm, uma vez que, de acordo com a revisão da literatura, é o mais adequado a aplicar à EDPR. A avaliação realizada levou à conclusão de que em 31/12/2014, as acções da EDPR tinham um valor intrínseco de - 6.49, estando dessa forma subvalorizadas, uma vez que a sua cotação era - 5.40 na data referida. Deste modo, com uma potencial valorização de 20.2%, foi possível dar uma recomendação de compra aos investidores interessados.
EDPR is a company that operates in the sector of the renewable energy and it is today one of the most important working in this area. Its main goal consists on being a reference in the industry for developing, building and operating the best wind farms and solar plants in the world. Unlike many other companies that are having some problems with the present economic framework, EDPR, by investing in a modern and most required sector, is successfully managing to overcome the difficulties and therefore it is building a significant and solid growth. The elaboration of this study has the aim to achieve the intrinsic value of EDPR stocks, by making a research of the operational performance and its exogenous environment. The method adopted in order to determine this value consists on the Free Cash Flow to Firm, since, according with the literature review, this is the most suitable one to apply to EDPR. The valuation performed led to the conclusion that on 31/12/2014, EDPR shares had an intrinsic value of - 6.49, being thus undervalued, since its quotation was - 5.40 at the time referred to. Therefore, with a potential appreciation of 20.2%, it was able to give a buy recommendation to the interested investors.

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Halderot, Karin, and Maria Sjöstrand. "EDA - På gott och ont : Förstföderskors kunskaper och behov av information om EDA." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12955.

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Bakgrund: Antalet förstföderskor som använder sig av EDA har ökat och idag använder dryga hälften EDA under förlossning. Det är den mest effektiva smärtlindringsmetoden som förlossningsvården har att tillgå. EDA vid förlossning är dock förknippat med biverkningar och risker. Barnmorskor har en viktig roll att ge information och undervisning om smärtlindring till gravida kvinnor. Syfte: Syftet med studien var att undersöka förstföderskors kunskaper och behov av information om EDA inför förlossning. Metod: Studien genomfördes och analyserades med metoden kvalitativ innehållsanalys med induktiv ansats. Semistrukturerade intervjuer genomfördes med åtta förstföderskor. Resultat: De analyserade intervjuerna utmynnade i två huvudkategorier; EDA är en metod med fördelar och nackdelar och Förstföderskor har behov av olika information på olika sätt, med tre, respektive två, tillhörande underkategorier. Konklusion: Kvinnornas kunskaper varierade, och många var osäkra. De hade behov av olika information om EDA på flera olika sätt. De upplevde att det varken fanns tid eller möjlighet för diskussion om EDA med barnmorskor, vilket kunde bidra till en känsla av att inte ha fått tillräckligt med information. Barnmorskor behöver därför blir bättre på att erbjuda förstföderskor information om EDA, men även annan smärtlindring som används under förlossning, förslagsvis genom uttökad tid på MHV.
Background: The number of primparas who use EDA has increased, and today more than half of them use EDA during childbirth. It is the most effective method of pain relief that is available in maternity care. EDA during childbirth is, however, associated with side effects and risks. Midwives have an important role to provide information and education about pain relief to pregnant women. Purpose: The purpose of this study was to investigate primiparas knowledge and need of information about EDA during childbirth. Method: The study was conducted and analyzed by qualitative content analysis method with inductive approach. Semi-structured interviews were conducted with eight primiparas. Results: The analyzed interviews resulted in two main categories; EDA is a method with advantages and disadvantages and Primiparas need different information in different ways, with three and two associated subcategories. Conclusion: The women's knowledges varied, and many were unsure. They needed different information about EDA in several different ways. They felt that there was neither time nor opportunity for discussion about EDA with midwives, which could contribute to a feeling of not having received sufficient information. Midwives must therefore improve in offering primiparas information about EDA, but also other forms pain relief used during childbirth, suggested by extended time at maternal health care.

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Lehmann, Rüdiger, and Antje Attrodt. "Epochenvergleiche von Präzisions-EDM-Messungen zur Untersuchung der Punktstabilität auf einer EDM-Basislinie." Hochschule für Technik und Wirtschaft Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:520-qucosa-204058.

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Auf der von der Hochschule für Technik und Wirtschaft Dresden betriebene EDM-Basislinie im Großen Garten in Dresden werden regelmäßig die Sollstrecken überprüft. Die Ergebnisse deuten auf Punktbewegungen hin. Durch Vergleiche zweier Epochen wird versucht, solche Punktbewegungen statistisch nachzuweisen, sowohl mittels statistischer Hypothesentests, als auch mit einem Informationskriterium. Punktbewegungen von bis zu 0,25 mm/a wurden geschätzt. Über die Ursachen wird noch spekuliert.

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Efthymiou, Georgios. "Etude d’assemblage et des fonctions des isoformes oncofoetales de la fibronectine." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR6024.

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La matrice extracellulaire (MEC) constitue une plateforme fibrillaire intégrant l'action des signaux chimiques et mécaniques de l'environnement. La fibronectine (FN), un composant majeur de la MEC, est au centre de cette plateforme de biorégulation et module de nombreuses actions biologiques telles que l’adhésion et la motilité cellulaires, la prolifération et la différenciation, ainsi que la structure et le dépôt de la MEC. La FN se présente sous deux formes : la FN plasmatique (pFN) et la FN cellulaire (cFN), dite « oncofoetale ». Cette dernière est nommée ainsi pour son expression uniquement au cours du développement et dans certaines conditions physiopathologiques (réparation tissulaire, inflammation et cancer). La différence entre les deux est l’existence dans la cFN des domaines supplémentaires EDB et EDA, qui résultent d’un épissage alternatif. Comment la présence de ces « extra-domaines », EDA et EDB , régit l'assemblage des FN et comment les variantes assemblées régulent le comportement des cellules est en grande partie inconnu. Des études de délétion ciblées d’un seul domaine chez la souris ont révélé le rôle de l'EDA dans des phénomènes très variés dont la morphogenèse des valves lymphatiques, l'athérosclérose et la cicatrisation / fibrose. Au niveau moléculaire, l'inclusion de l'EDA élargit le répertoire des récepteurs cellulaires de la FN (intégrines α4β1, α7β1 et TLR4). A ce jour, aucun récepteur n'a été rapporté pour l’EDB. De ce fait il a été proposé que sa présence modifierait la conformation du site de liaison de FN aux cellules et faciliterait ainsi l’assemblage fibrillaire induit par les intégrines via des mécanismes qui restent à établir.Le but des travaux de cette thèse était de décoder les rôles de l'EDA et de l'EDB de la FN, et plus précisément de :1) étudier l'impact de la présence des domaines EDA et EDB sur l'assemblage fibrillaire de la FN à la surface de cellules compétentes pour l'assemblage, et2) déterminer comment la présence de l’EDB et de l’EDA influence les propriétés biochimiques, physiques et fonctionnelles de la matrice, qui à leur tour affectent le comportement des cellules qui y sont attachées.Dans un premier temps l’équipe a développé un ensemble d'outils biologiques composé de : i) vecteurs lentiviraux hébergeant la séquence codante complète du gène de la cFN humaine contenant l’un, les deux ou aucun des « extra-domaines » alternativement épissés, ii) des variants de FN recombinants purifiés, iii) des fibroblastes embryonnaires de souris FN -/- (Fn1 -/- MEF), et iv) des MEF exprimant des variantes de FN. Cette batterie outils uniques a été utilisée pour étudier l'assemblage spécifique de variantes par les fibroblastes et les effets de réseaux de cFN homogène sur le comportement cellulaire.Nos résultats ont montré que les « extra-domaines « de la FN sont responsables au niveau des fibroblastes du réglage fin de l’amplitude de plusieurs réponses dont l’assemblage de la matrice, la croissance et le métabolisme énergétique. En utilisant une approche informatique « non-biaisée », nous avons démontré que la présence des « extra-domaines » modifie la structure de la matrice de la FN déposée par les fibroblastes. Ceci témoigne d’événements de signalisation cellulaire différents, qui sont susceptibles de modifier aussi bien les réponses précoces que tardives induites par la FN. Les matrices variant-spécifiques que nous avons développées représentent des outils très puissants pour décrypter les fonctions des « extra-domaines » de la FN dans les multiples types de cellules impliquées non seulement dans des réponses physiologiques mais également dans des situations pathologiques
The Extracellular Matrix (ECM) constitutes a fibrillar platform that integrates the action of chemical and mechanical cues from the environment. Fibronectin (FN), a major component of the ECM, is at the center of this bioregulatory stage, modulating numerous biological procedures such as cell adhesion and motility, cell proliferation and differentiation, as well as ECM deposition and structure. FN is found in two forms: plasma FN (pFN) and cellular FN (cFN). cFN differs from pFN by the presence of alternatively spliced Extra Domains, namely EDB and EDA. Each of these alternatively spliced regions is encoded by a single exon, the regulation of which is strictly regulated and limited to embryonic tissues, as well as pathophysiological conditions such as wound healing, inflammation, and cancer. The term “oncofetal” was coined in order to describe FN isoforms harboring either of the Extra Domains, that are normally absent in adult tissues.How the presence of EDA and EDB regulates FN assembly and how the assembled variants regulate cell behavior is largely unknown. Single Extra Domain-targeted deletion studies in the mouse have revealed roles for EDA in the morphogenesis of lymphatic valves, atherosclerosis, and wound healing/fibrosis. Mechanistically, the inclusion of EDA expands the repertoire of cellular FN receptors (α4β1, α7β1 integrins and TLR4). To date, no ligand has been reported for EDB. Rather, its presence has been postulated to alter the conformation of the cell-binding domain of FN and to facilitate integrin-driven fibrillar assembly by mechanisms that remain to be established.The aim of this dissertation is to provide more insight regarding the roles of the FN Extra Domains EDA and EDB, and more specifically:1) To investigate how the presence of alternatively spliced EDA and EDB domains affect the fibrillar assembly of FN at the surface of assembly-competent cells, and2) To determining how the presence of EDB and EDA influences the biochemical, physical, and functional properties of the matrix that in turn affect the behavior of cells attached to it.Here we present a biological toolset composed of : i) lentiviral vectors harboring the full-length coding sequence of human cFN containing one, both, or none of the alternatively-spliced Extra Domains, ii) purified recombinant FN variants, iii) FN-null mouse embryo fibroblasts (MEFs) and iv) FN variant-expressing MEFs. These unique tools were used to study variant-specific assembly by fibroblasts and the effects of homogeneous cFN networks on cell behavior.Utilizing an unbiased computational approach, we document that the presence of the Extra Domains results in a distinct pattern of FN deposition and assembly that in turn influences both early and late signaling events that control cell proliferation as well as cell contractility. Finally, we present a series of novel data that point towards a FN-impacted control of cell energetics.We conclude that FN Extra Domains are responsible for the fine-tuning of the extent of several cellular processes that can reflect strict regulation in pathophysiological procedures such as tissue repair, fibrosis, and tumor progression

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Strömberg, Mikaela. "EDI-prestation och en stundande fusion : - Fallstudie om EDI-prestation på ett nybildat pappersbolag." Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-27761.

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Dagens företag befinner sig i komplexa nätverk av interagerande företag, då de tillsammans kan nå ett högre värde. Varje interaktion innebär att företagen delger information, detta kan ske elektroniskt via Electronic Data Interchange, EDI, (Johansson, 1994). Sättet att styra och leda EDI har blivit en nyckelfaktor hos de flesta IS (Informations System) chefer. EDI-prestationer skiljer sig ofta företag emellan och därför är det viktigt att förstå vilka faktorer som påverkar EDI-utförandet (Lee & Lim, 2003). Syftet med denna studie är att beskriva hur EDI-prestation påverkas vid en fusion av två företag och hur företag kan arbeta proaktivt för att EDI-prestationen skall utvecklas. Studien är en kvalitativ fallstudie, på företaget X som befinner sig i stundande fusionsarbete, en deduktiv ansats har tillämpats. För att besvara studiens frågeställning och syfte har i huvudsak primärdata insamlats i form av intervjuer och observationer hos företag X. I affärsrelationer är det medarbetarna som representerar företaget och dess värderingar. Därför är det viktigt att beakta hur dessa interaktioner sker mellan företagens medarbetare samt om personerna har tillräcklig kompetens (Ertzgaard, 2004). Lee och Lim (2003) skriver att EDI-prestation kan mätas utifrån tre egenskaper i affärsrelationer; förtroende, självständighet och engagemang samt ur tre EDI-dimensioner; Integration, användning och mångfald och att egenskaperna i relationerna påverkar EDI-prestationen. Fallföretagets nya utseende innebär en större tillgång på resurser och fusionen gör det möjligt att öka integrationen och användningen av EDI genom att minska mångfalden. Det är därför viktigt att en vision och mål sätts för hur företaget X skall arbeta med sin EDI samt att medarbetarnas värde för affärsrelationerna beaktas. Slutsatsen blir att en fusion tycks kunna påverka EDI-prestationen utifrån förtroendeaspekten, mångfaldsaspekten och självständighetaspekten. Även arbetssätt för EDI-projekt i företaget ändras i och med att ett nytt företag sätter nya visioner och värderingar som även EDI-arbetet bör efterleva.

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Dissertations / Theses on the topic 'EDD'

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