Dissertations / Theses: 'Eczema'

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Guttmann, Oliver. "Hand eczema." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-88559.

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Guttmann, Oliver Philipp. "Hand eczema." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8855/.

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Meggitt, Simon. "Azathioprine for atopic eczema." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427279.

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Rodriguez, Elke. "Genetic Susceptibility Factors for Eczema." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-134960.

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MOYSSET, LAURENT. "Pseudokyste auriculaire et eczema atopique." Toulouse 3, 1992. http://www.theses.fr/1992TOU31066.

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Hespel, Olivier. "La corticothérapie de l'eczéma." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P084.

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Mont, G. C. L. du. "Food allergy in childhood atopic eczema." Thesis, University of Newcastle Upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376981.

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Bes, Georges. "Caractère psychologique de la dermatite atopique." Montpellier 1, 1997. http://www.theses.fr/1997MON11067.

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Josefson, Anna. "Nickel allergy and hand eczema : epidemiological aspects." Doctoral thesis, Örebro universitet, Hälsoakademin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11855.

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Nickel allergy is the most prevalent contact allergy and has been discussed as a possible riskfactor for hand eczema. However, hand eczema is one of the most frequently occurring skindiseases and has multifactorial origin. The aim of this thesis was to study the association between nickel allergy and hand eczema in the general population. There are only a fewpopulation-based studies previously published, that include patch testing. In addition, this thesis aimed to evaluate methods to follow the prevalence of nickel allergy.The study cohort consisted of 908 women who had been patch tested for the occurrence of nickel allergy as schoolgirls. Twenty years later, they were invited to participate in a follow-up questionnaire study. The response rate was 81%. In total, 17.6% of respondents reported handeczema after the age of 15 years and there was no statistically significant difference in the occurrence of hand eczema between those who were nickel-positive and those who were nickel negativeas schoolgirls. To further investigate possible links, another study was performed,which included a second questionnaire, a clinical investigation and patch testing. All schoolgirls from the baseline study who were still living in the area as adults were invited to participate and the participation rate was 77%. Patch test showed 30.1% nickel-positive individuals.When all participants were included in the analysis, there was no statistically significant difference between nickel-positive and nickel-negative women regarding occurrence of hand eczema. The most important risk factor for hand eczema was childhood eczema. Adjusted prevalence proportion ratio (PPR) for hand eczema after age 15 in relation to nickel patch testresults was 1.03 (95% CI 0.71--1.50) and in relation to childhood eczema 3.68 (95% CI 2.45--5.54). When women with and without history of childhood eczema were analyzed separately, the hand eczema risk was doubled in nickel-positive women without history of childhood eczema. In conclusion, the risk of hand eczema in nickel-positive women may previously havebeen overestimated. Next, the validity of self-reported nickel allergy was investigated. In the established cohort; two questions regarding nickel allergy were compared with patch test results. The validity of self-reported nickel allergy was low, and the questions regarding nickel allergy overestimated the true prevalence of nickel allergy. The positive predictive values were 59% and 60%. Another method for estimating the prevalence of nickel allergy, namely self-patch testing, was validated in the last study. In total, 191 patients from three different dermatology departments participated. The validity of self-testing for nickel allergy was adequate, with sensitivity 72%and proportion of agreement 86%.
Nickelallergi är vanligt förekommande. Prevalensen i Skandinavien är 15--25% hos kvinnor och cirka 3% hos män. Sambandet mellan nickelallergi och uppkomst av handeksem har tidigare diskuterats och i vissa studier anges att 30--45% av alla individer med nickelallergi får handeksem. Det finns dock endast ett fåtal publicerade studier där personer ur normalbefolkningen har lapptestats för nickel. Handeksem ärvanligt och har ofta flera olika kombinerade orsaker. Det övergripande syftet med avhandlingen var att studera nickelallergins betydelse för uppkomst av handeksem. Detfinns ett intresse av att följa förekomsten av nickelallergi över tid, speciellt sedan det i början av 2000-talet infördes ett EU-direktiv som begränsar nickelinnehåll i klockor,smycken, metallknappar etc. Ytterligare ett syfte med avhandlingen var att utvärderaepidemiologiska metoder för att följa förekomsten av nickelallergi.Den första studien var en uppföljningsstudie av 908 flickor ur normalbefolkningen,vilka i skolåldern lapptestats med nickel. Tjugo år senare skickades en enkät till dessa kvinnor, svarsfrekvensen var hög (81%). Förekomsten av självrapporterat handeksemefter 15 års ålder var 17.6%. Det förelåg ingen signifikant skillnad i förekomst avhandeksem mellan de kvinnor som var nickelallergiska som barn jämfört med dem som inte var nickelallergiska. År 2006 utfördes ytterligare en studie, som inkluderade de kvinnor som fortfarande bodde i Örebro län. Studien omfattade en klinisk undersökning av händerna samt ett lapptest. 30% av kvinnorna var positiva för nickel.Det förelåg ingen signifikant skillnad i förekomst av handeksem mellan de som var positiva för nickel och de som var negativa. Vid separat analys av de kvinnor som angav tidigare barneksem jämfört med dem som aldrig hade haft barneksem visade det sig att risken för handeksem var dubbelt så stor hos nickelallergiker i den gruppen som aldrig hade haft barneksem. Båda studierna visade att barneksem var den största riskfaktorn för att få handeksem som vuxen, med en 3-4 gånger ökad risk. Den tredje studien var en validering av självrapporterad nickelallergi. Överensstämmelsen var låg mellan enkätfrågor gällande nickelallergi och lapptestverifierad nickelallergi. Av dem som själva bedömde sig vara nickelallergiska var endast 59% positiva enligt lapptest. För att följa förekomsten av nickelallergi i befolkningen behövs därför andra metoder. I den fjärde studien utvärderades ett självtest för nickelallergi. 191 patienter från tre olika hudkliniker i Sverige deltog i studien. Validiteten för metoden självtest var tillfredsställande, sensitiviteten var 72%och graden av överensstämmelse var 86%.

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Kobata, Clarice Marie. "Testes de contato em crianças com eczema." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-20092010-171934/.

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Introdução: Eczemas são manifestações inflamatórias da pele. Na infância se destacam a dermatite atópica (DA) e a dermatite de contato (DC). Os testes de contato correspondem a um método auxiliar para diferenciar a dermatite de contato por irritante primário (DCIP) da dermatite de contato alérgica (DCA) e definir a etiologia da DCA. Nos pacientes com DA, têm a faculdade de também auxiliar na identificação de substâncias que possam estar contribuindo para a piora do quadro. Objetivos: verificar a frequência de testes de contato positivos em crianças com hipóteses diagnósticas de DC e de DA associada ou não à DC; obter os principais sensibilizantes nessa faixa etária e comparar os dados obtidos entre os grupos de pacientes com DC e DA. Métodos: Durante o período entre julho de 2007 e agosto de 2009, 62 crianças com idades entre 2 e 12 anos foram submetidas aos testes de contato com a bateria padrão e/ou bateria de cosméticos de testes de contato padronizadas pelo Grupo Brasileiro de Estudos em Dermatite de Contato. As leituras foram realizadas em 48 e 96 horas. Resultados: Entre os 62 pacientes submetidos aos testes de contato, 38 pacientes apresentaram pelo menos um teste de contato positivo e 24, todos negativos. Entre os 44 pacientes com hipótese diagnóstica inicial de DA, 19 tinham DA associada à DCA. Entre os 18 pacientes com hipótese diagnóstica inicial de DC, 12 apresentavam DCA. No total, foram encontrados 76 testes positivos, sendo 53 (70%) relevantes, e 23 (30%) não relevantes com a história clínica do paciente. Os pacientes com DA apresentaram mais testes positivos não relevantes do que os pacientes com hipótese diagnóstica apenas de DC, e essa diferença foi estatisticamente significativa.( 2 = 6,55 e p = 0,01 ). Considerando os testes relevantes com a história clínica, o sulfato de níquel foi o principal sensibilizante com 14 (22,6%) testes positivos, a neomicina foi o segundo sensibilizante mais comum com sete testes positivos (11,3%), e a terceira substância mais comum foi o cloreto de cobalto com quatro (6,4%) testes positivos. Testes não relevantes foram encontrados em 30% do total de substâncias com testes positivos. O timerosol foi positivo em 11 casos, porém em oito pacientes com DA não foram relevantes com a história clínica. Conclusões: Pacientes na faixa etária entre 2 e 12 anos com DA e DC apresentaram testes de contato positivos, e não houve diferenças quanto à frequência dos testes positivos entre esses dois grupos. Os principais sensibilizantes relevantes com a história clínica foram o sulfato de níquel, a neomicina e o cloreto de cobalto, o que está de acordo com vários estudos na literatura. Pacientes com DA apresentaram mais testes falso-positivos que os pacientes com DC, possivelmente por um defeito da barreira cutânea dos pacientes com DA, e maior exposição precoce aos medicamentos tópicos ou emolientes para o controle da DA. Teste de contato em crianças pode ser considerado importante ferramenta para auxiliar no diagnóstico dos eczemas, identificando o agente causador da DC ou de piora nos casos de DA, e deve ser levado em conta em todos esses pacientes
Eczema is a cutaneous inflammatory manifestation in some dermatosis. In children, we highlight atopic dermatitis (AD) and contact dermatitis (CD). Patch tests help to differentiate irritative contact dermatitis (ICD) from allergic contact dermatitis (ACD), and define the etiology of allergic contact dermatitis. In patients with AD, it may also help to identify substances that may contribute to the worsening of this dermatosis. Objectives: To determine the frequency of positive patch tests in children with diagnosis of CD and AD with or without CD; to detect the main sensitizers in this group and compare the results between the groups of patients with CD and AD. Methods: From July 2007 to August 2009, 62 children aged between 2 to 12 years old were patch tested with the Brazilian standard battery of patch tests and cosmetic series. The readings were taken at 48 and 96 hours. Results: Thirty-eight patients had at least one positive patch test reactions and 24, all negative. Among the 44 patients with initial diagnosis of AD, 19 were associated with ACD. Among the 18 patients with initial diagnosis of CD, 12 had ACD. In total, there were 76 positive tests, 53 (70%) relevant, and 23 (30%) not relevant to the patient\'s clinical history. Patients with AD showed more positive tests not relevant than patients with diagnosis of CD only, and this difference was statistically significant. (2 = 6.55 and p = 0.01). Considering the relevant tests, nickel sulphate was the main allergen with 14 (22.6%) positive tests, neomycin was the second with seven positive tests (11.3%), and the third substance was cobalt chloride with four (6.4%) positive tests. Tests not relevant were found in 30% of the total of the positive tests. Thimerosol was positive in 11 cases, but in eight patients with AD were not relevant to the clinical history. Conclusions Patients aged between 2 to 12 years old with AD and CD had positive tests, and there were no differences in the frequency of positive tests between these two groups. The main sensitizers, relevant to the clinical history were nickel sulfate, neomycin and cobalt chloride. This result is consistent with several studies in the literature. Patients with AD showed more false-positive tests than patients with CD, possibly due to a defective skin barrier of AD patients, and earlier exposure to topical emollients and treatments for the control of AD. Patch test in children can be considered an important tool for the diagnosis of eczema, identifying the causative agent of CD or worsening cases of AD, and should be performed in all these patients. The correct interpretation of the patch tests is essential to evaluate the association of ACD in patients with AD and to identify the causative agent of the ACD

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Devenney, Irene. "Assessing eczema and food allergy in young children." Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7128.

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Lind, Marie-Louise. "Hairdressers - hand eczema, hair dyes and hand protection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-900-9/.

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Goodyear, Helen Margaret. "Herpes simplex infections in children with atopic eczema." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390112.

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Andersson, Gunilla, and Suzan Lidsten. "Quality of life among patients with atopic eczema." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24100.

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Atopiskt eksem kännetecknas av en torr hud med hudsprickor som ger en svår klåda. Behandlingen går ut på att identifiera, minimera och eliminera faktorer som är utlösande och försämrande. Mjukgörande medel används dagligen för att före-bygga uppkomsten av nytt eksem. Att leva med atopiskt eksem kan vara ett stort handikapp med personliga, sociala och ekonomiska inskränkningar som leder till en sämre livskvalitet. Syftet med litteraturstudien är att klargöra om patienter med atopiskt eksem kan förbättra sin livskvalitet genom att få utbildning om sin sjuk-dom. Metoden som har använts är en litteraturstudie där artiklar har sökts i data-basen PubMed och bedömts efter ett modifierat granskningsprotokoll för kvali-tetsvärdering av artiklarna. Sammanställningen bygger på 10 artiklar där resultatet inte ger ett starkt stöd för att patientutbildning ger en förbättrad livskvalitet. Ytter-liggare forskning behövs med större och mer omfattande studier för att kunna på-visa huruvida patientutbildning ger förbättringar i livskvaliteten hos patienter med atopiskt eksem.
Atopic eczema is characterized by a dry skin with dermal tearing giving a severe itching. The treatment is to identify, minimize and eliminate factors that trigger and adverse. Softening agents are used daily to prevent the formation of new eczema. Living with atopic eczema can be a major handicap with personal, social and economic restrictions that might lead to a reduced quality of life. The purpose of this literature study is to clarify whether patients with atopic eczema may improve their quality of life by receiving education of their illness. The method used is a literature review which items have been sought in the database PubMed and assessed by a modified examination protocol for quality assessment of articles. The compilation is based on 10 articles in which the results do not provide strong support for patient education provides an improved quality of life. Further research is needed with larger and more extensive studies to demonstrate if improvements can be shown in quality of life in patients with atopic eczema.

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Al-Amri, Mohammad Abdulla. "Atopic dermatitis : the role of contact allergy in disease and disease exacerbations." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274922.

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Nordstrand, Eva. "Cognitive Behaviour Therapy – A Therapy for Atopic Eczema? : A quasi-experimental, longitudinal study of changes in symptoms of atopic eczema in children." Thesis, Uppsala University, Department of Education, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128915.

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McNally, Nicholas James. "The environment, lifestyle and atopic eczema : a geographical perspective." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297751.

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Christofidou, Maria. "Genetic basis of childhood eczema : investigation of candidate genes." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706278.

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GIRARD, JEAN-LOUIS. "Hypothese psychodynamique de la constitution de l'eczema atopique." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20350.

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Кунцевич, Ю. П., О. В. Тригуб, and Г. М. Стасюк. "Особливості рівня статевих гормонів у жінок перименопаузального віку хворих на екзему." Thesis, Видавництво СумДУ, 2004. http://essuir.sumdu.edu.ua/handle/123456789/9708.

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Евдошенко, К. И., and Н. А. Дудченко. "Результаты лечения экземы у работниц швейного производства с учетом патогенетических механизмов." Thesis, Видавництво СумДУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/11275.

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Біловол, А. М., and А. М. Дащук. "Классифiкацiя компенсаторних реакцiй контактно - захисних систем при екземi." Thesis, Видавництво СумДУ, 2005. http://essuir.sumdu.edu.ua/handle/123456789/12671.

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LEFEBVRE, MARIE. "Contribution a l'etude de l'eczema constitutionnel et de son traitement par l'hyposensibilisation a propos de 130 cas." Lille 2, 1989. http://www.theses.fr/1989LIL2M156.

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Worthington, Jo. "Living with visible eczema : an exploration of young people's experiences." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434517.

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Norrman, Gunilla. "Eczema in young children : aspects of clinical investigation and treatment." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med999s.pdf.

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Banerjee, Piu. "Immune mechanisms in atopic eczema and the impact of therapy." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391635.

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Rodríguez, Elke [Verfasser], and Thomas [Akademischer Betreuer] Cremer. "Genetic Susceptibility Factors for Eczema / Elke Rodriguez. Betreuer: Thomas Cremer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015925197/34.

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Abrahamsson, Thomas, Hedvig E. Jakobsson, Anders F. Andersson, Bengt Björksten, Lars Engstrand, and Maria Jenmalm. "Low diversity of the gut microbiota in infants with atopic eczema." Linköpings universitet, Pediatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75901.

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Background It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts. Objective We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development. Methods Microbial diversity and composition were analyzed with barcoded 16S rDNA 454-pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age in 20 infants with IgE-associated eczema and 20 infants without any allergic manifestation until 2 years of age (ClinicalTrials.gov ID NCT01285830). Results Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P = .004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation (Empirical Analysis of Digital Gene Expression in R [edgeR] test: P = .008, q = 0.02). Conclusion Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema.

Funding Agencies|BioGaia AB, Stockholm, Sweden||Ekhaga Foundation, the Heart and Lung foundation||Research Council for the South-East Sweden|F2000-106|Olle Engqvist Foundation||Swedish Asthma and Allergy Association||Swedish Research Council||University Hospital of Linkoping||Soderberg Foundation||Vardal Foundation for Health Care Science and Allergy Research, Sweden||BioGaia AB||

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Sloper, K. S. "An immunological investigation into the aetiology of atopic eczema in children." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233526.

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Large, Juliette. "Characterisation of Staphylococci associated with atopic eczema and chronic plaque psoriasis." Thesis, Aston University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341358.

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Souza, Renata Gontijo Lima de. "Prevalência de asma, rinite e eczema atópicos em escolares de 6 a 7 anos na região oeste da cidade de São Paulo, através do questionário padronizado do International Study of Asthma and Allergies in Childhood (ISAAC) - Fase IIIB." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-04042007-144126/.

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INTRODUÇÃO: O conhecimento da prevalência das doenças alérgicas é de fundamental importância para a instituição de medidas para sua prevenção. Vários métodos têm sido utilizados para este fim, sendo que recentemente o questionário padronizado ISAAC (International Study of Asthma and Allergies in Childhood) tem permitido a comparação dos dados epidemiológicos em várias regiões. Os OBJETIVOS deste estudo foram: avaliar a prevalência da asma, rinite e eczema atópicos e sintomas relacionados, entre escolares de 6 a 7 anos, da região oeste da cidade de São Paulo, utilizando-se o questionário escrito ISAAC e comparar os dados encontrados com aqueles obtidos na fase I do Estudo ISAAC em São Paulo, examinando tendências temporais na prevalência das doenças alérgicas. MÉTODOS: Entre junho e outubro de 2002 foi aplicado questionário escrito ISAAC em 3.312 alunos. As diferenças entre proporções foram avaliadas pelo Teste do Qui-quadrado e quando necessário o Teste Exato de Fisher, sendo também calculados a Razão das Chances (Odds Ratio OR) e intervalo de confiança 95% (IC 95%) entre os sexos e na associação das doenças alérgicas. Os valores de p < 0,05 foram considerados de significância estatística. Após obtenção dos resultados, procedeu-se a nova análise, convocando-se uma amostra dos alunos que não haviam devolvido o questionário, sendo estes novos resultados considerados na análise final. RESULTADOS: As prevalências encontradas foram: asma de 24,4%, diagnóstico médico de asma 5,7%, diagnóstico de asma provável 21,5%, rinite de 25,7%, rinoconjuntivite de 11,3% , diagnóstico médico de rinite 20%, eczema atópico de 9,2% e o diagnóstico pelo critério combinado de 5,7%. Houve associação entre asma, rinite e eczema atópico em 3,8% dos escolares. O sexo masculino foi predominante para sintomas de asma e rinite, não havendo diferença para eczema. Comparando-se os dados da fase I aos dados atuais, observou-se prevalência mais elevada dos sintomas e gravidade de asma e valores menores para sintomas de rinite e eczema. CONCLUSÕES: As prevalências de asma e rinite neste estudo mostraram valores elevados em comparação ao diagnóstico médico. A prevalência de eczema atópico foi maior que aquela avaliada pelo critério combinado. Houve predomínio do sexo masculino nas respostas positivas para asma e rinite. As associações mais freqüentes foram entre asma e rinite e entre asma e eczema, havendo associação das três doenças em pequeno número de alunos. Em comparação aos dados da Fase I na região centro-sul de São Paulo, observou-se que na região oeste houve maior prevalência dos sintomas e gravidade da asma e menor prevalência de rinite e eczema.
INTRODUCTION: The knowledge about the prevalence of allergic diseases is important to introduce prevention strategies. The written questionnaire standardized by \"International Study of Asthma and Allergies in Childhood\" - ISAAC, has been used to compare epidemiological data from different regions. The aims of the present study were: to evaluate the prevalence of asthma, rhinitis and allergic eczema and related symptoms, among students from 6 to 7 years in the west area of São Paulo city, through the written questionnaire from the ISAAC study, to compare this data with those obtained in ISAAC Phase I in São Paulo identifying temporal trends in the allergic diseases prevalence. METHODS: In the period from June to October/2002 written questionnaire were applied to 3312 students. The proportion differences were estimated by Qui-square or Fisher exact test. Odds Ratio (OR) and 95% confidence interval (IC95%) between gender and the allergic diseases were evaluated. Values of p < 0,05 were considered statistically significant. RESULTS: The prevalence found were: asthma 24,4%, medical diagnosis of asthma 5,7%, probable asthma 21,5%, rhinitis 25,7%, rhino conjunctivitis 11,3%, medical diagnosis of rhinitis 20%, atopic eczema 9,2% and the medical diagnosis by the combined criterion of eczema 5,7%. There was association among asthma, rhinitis and atopic eczema in 3,8% of the schoolchildren. Male sex was prevalent in all of the subjects regarding asthma and rhinitis, but there was no difference about gender for atopic eczema. In comparison with data from ISAAC phase I, in this study it was observed higher prevalence and severity of asthma and lower values for rhinitis and eczema symptoms. CONCLUSIONS: This study demonstrated high prevalence of asthma and rhinitis when compared to their medical diagnosis. The prevalence of atopic eczema was higher than combined criterion. The male gender predominates in all positive responses regarding asthma and rhinitis. The more frequent association was observed between asthma and rhinitis, asthma and eczema, and a low number of schoolchildren presented the three allergic diseases. Comparing with phase carried out at the south area of São Paulo city, in the west region there were higher prevalence of symptoms and severity of asthma, lower prevalence of rhinitis and eczema.

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Xu, Xiao-Jun. "Immune dysfunction in the skin in atopic dermatitis and its modulation by Chinese herbal therapy." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314362.

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Jones, Samatha Anne Vaughan. "A prospective study of the dermatoses of pregnancy : correlation of the clinical findings wiht hormonal and immunopathological profiles." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267828.

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Vestey, James Patrick. "Antigen presentation and systemic immune responses to herpes simplex virus in patients with recrudescent facial herpetic infections." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259925.

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Accary, Pierre. "Dermites de contact aux endives." Amiens, 1992. http://www.theses.fr/1992AMIEM122.

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Fenouillet, Pierre. "Evolution et facteurs pronostiques du syndrome dermo respiratoire : à partir d'une étude rétrospective portant sur 24 cas." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M090.

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Johansson, Catharina. "The role of Malassezia in the pathogenesis of atopic eczema/dermatitis syndrome /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-127-6/.

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Lam, Hiu-wa, and 林曉樺. "The use of a nurse-led education program in reducing pediatric eczema." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48335599.

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Atopic eczema is a chronic relapsing inflammatory skin disease commonly associated with atopy. The disease is common in early childhood and is characterized by dryness of skin, itchiness and skin flexures. There has been no cure for the disease. Treatments of atopic eczema focus on relieving symptoms, maintaining skin integrity and preventing secondary infection. With good compliance to the treatment, most patients may obtain optimal control. Education is essential for good compliance to the treatment. In local public acute hospitals, the current service provided restricts the time for comprehensive patient education during follow-up by physicians. Some studies indicated that nurse-led programs are effective in managing chronic illness because patients have longer consultation time and more information. The effect of nurse-led program in managing common chronic disease like atopic eczema may be promising. However, there was no systematic review on the use of nurse-led education program in reducing pediatric eczema in the local setting. Against the above background, this dissertation aims to systematically evaluate the current evidences on the effectiveness of nurse-led education program for pediatric eczematous patients in reducing the severity of eczema, to develop an evidence-based guideline of the program, to assess the implementation potential and to develop implementation strategies and evaluation plan. A systemic review of the literature from Medline (Ovid SP), PubMed and CINAHL (EBSCOhost) was conducted. A total of 298 citations were retrieved after the database search. Finally, 5 studies were identified and included in the systemic review. Data were extracted and the quality of each included studies was assessed with the help of the appraisal instruments. In which, one study was methodologically strong, two studies were of moderate methodological qualities and two studies were of poor methodological qualities. Among the four studies with severity of eczema as outcome measures, three studies showed significant in reducing severity of eczema. Therefore, we considered sufficient evidence that supported the use of nurse-led education program in reducing pediatric eczema. An evidence-based guideline of the program was developed. The characteristics of the patients in the local setting are similar to those of the identified studies. The availability of the resources and the readiness of the staff towards the proposed innovation are supportive in the local setting. Thus the findings of the reviewed studies were transferable and the proposed innovation was feasible. Cost-benefit analysis showed that the proposed program could be able to generate a potential saving of about $ 550,000 in the local setting annually. In the implementation plan, a three-month pilot study on ten patients will be conducted before the implementation of the program. Evaluation will be made after the end of the pilot study and the end of the implementation program. Refining of final protocol will be done according to the evaluation and comments from the pilot study. The severity of eczema and the patient’s satisfaction are considered as primary and secondary patient outcomes respectively. The healthcare provider outcomes are the staff morale and the workload. Systematic outcomes are the admission rate of pediatric ward and the attendance rate of pediatric outpatient clinic, and the cost of innovation. Finally, patient outcomes, healthcare provider outcomes and systemic outcomes would be evaluated in order to identify the effectiveness of the program.
published_or_final_version
Nursing Studies
Master
Master of Nursing

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Sinclair, Claire. "The genetics of atopic eczema in the Bangladeshi population of East London." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1898.

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Atopic Eczema (AE) is a common, complex, genetic skin disease. It usually begins in infancy and can affect any part of the body but often occurs in the flexures of the elbows and knees. The cohort used in this study is of Bangladeshi origin and all subjects reside in East London. Using a combination of techniques, such as the Illumina goldengate assay, PCR and sequencing, both novel and previously associated genes have been studied in this thesis. Previously associated genes were used to validate this population and also to investigate the variation of genes associated in different ethnic populations. Six of eleven previously associated genes were replicated in this population. In order to identify novel genes of interest in AE, sixteen novel genes were chosen for investigation. Of these sixteen, eight showed association with AE. A recently identified gene involved in the pathogenesis of AE, Filaggrin (FLG), was also investigated. This was done using a combination of PCR, sequencing and Taqman SNP assays. Only six families out of 80 in this population were found to harbour the two known common FLG mutations. These families were clinically reassessed for Ichthyosis Vulgaris (IV) which is also associated to the same FLG mutations. After this reassessment the FLG mutations were shown to be associated with IV in this population with variable penetrance. No association with AE was found. ABCA12 was also investigated as a candidate gene for AE, again using the Illumina goldengate assay and microsatellite linkage markers. Association was observed with this gene and AE. Harlequin Ichthyosis (HI) mutations were also screened in this gene for twelve additional HI patients. This thesis has provided a greater insight into the variation of gene associations between populations with AE, highlighting novel genes, including KY-NU and JAK3/INSL3, which need to be investigated in other populations.

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Syck, Megan Paige. "Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618.

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Онуцька, О. Д. "Комплексне лікуваня атопічного дерматиту із застосу- ванням крему “Дермалекс/ Dermalex atopic eczema”." Thesis, Буковинський державний медичний університет, 2012. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/2820.

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Gamradt, Pia. "Tissue-resident memory T cells in eczema : contribution and protective regulatory mechanisms." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1306/document.

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Les eczémas [eczéma allergique de contact (EAC) et l'eczéma atopique (EA)] sont des dermatoses inflammatoires fréquentes des pays industrialisés. Elles sont induites suite au recrutement et à l'activation dans la peau de lymphocytes T spécifiques d'allergènes, qui sont présents dans notre environnement, et qui sont habituellement très bien tolérés par la majoritédes individus exposés. Ce travail de thèse porte sur un aspect novateur de la physiopathologie des eczémas, à savoir : la contribution des lymphocytes T mémoires résidants (LTrm) dans la peau à la chronicité et à la sévérité de ces maladies.Capitalisant sur des modèles précliniques pertinents ainsi que sur des échantillons cliniques prélevés chez les patients, ce travail a permis d'acquérir de nouvelles connaissances : (i) de nombreux LTrm CD8+ spécifiques colonisent les lésions d'eczéma (ii) ils s'accumulent avecla persistance de l'allergène dans la peau, (iii) ils jouent un rôle majeur dans les récidives de la maladie, mais (iv) ils expriment à leur surface divers récepteurs inhibiteurs, tels que PD-1 ou TIM-3, qui empêchent la survenue de réponses allergiques excessives.Ces travaux apportent donc des informations majeures sur la nature unique des LTrm CD8+ spécifiques d'allergènes et des mécanismes qui contrôlent leur réactivation, afin de préserver l'intégrité de la peau et la survenue de réactions chroniques sévères. Le développement des nouvelles stratégies thérapeutiques ciblant la réactivation des LTrm via leurs récepteursinhibiteurs pourrait permettre de restaurer la tolérance chez les individus allergiques
Allergic contact dermatitis (ACD) and atopic dermatitis (AD), also referred to contact or atopic eczema, are frequent skin inflammatory diseases with increasing prevalence and high socioeconomic impact in Western countries. Eczemas are the prototype of skin delayed-type hypersensitivity reactions. Skin lesions are induced by the recruitment and activation in the skin of effector/memory T cells specific for environmental antigens that are innocuous to healthy non-allergic individuals.The aim of this work was to better understand the pathophysiology of eczemas by a comprehensive analysis of the contribution of skin resident memory T cells (Trm) to the chronicity and severity of these diseases.Capitalizing on relevant preclinical eczema models and on clinical samples collected from allergic patients, this work showed that: (i) numerous allergen-specific CD8+Trm colonize the eczema lesion, (ii) they accumulate in the epidermis in response to the long-term persistence of the allergen in the skin, (iii) they are instrumental for the recurrence of eczema, but (iv) theyexpress several inhibitory check point receptors (ICRs, such as PD-1, TIM-3) at their surface, which keep them in check to prevent the development of severe immunopathology.Thus, our work provides important information for considering the unique nature of hapteninduced CD8+ Trm and the mechanisms that prevent their unwanted reactivation and subsequent development of chronic or severe skin allergy. The development of therapeutic strategies targeting the reactivation of skin Trm in situ via their ICRs should open new avenues to restore tolerance in allergic individuals

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Gillespie, G. N. "An investigation into the effects of childhood atopic eczema on parental stress." Thesis, Bangor University, 1996. https://research.bangor.ac.uk/portal/en/theses/an-investigation-into-the-effects-of-childhood-atopic-eczema-on-parental-stress(38a01a84-71ef-4315-9b9f-01223d21a016).html.

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Very little research has examined stress among parents of children with atopic eczema, though stressful events arc widely Implicated In Its actiology. This study Investigated reported stress among 38 parents of children with atopic eczema who had received hospital out-paticnt trcatmcnt within the previous 12 months. Responses of parents on the Parenting Stress Index were compared with published norms. Significantly elevated levels of stress among the study sample were found on the Difficult Child subscale. Total stress scores showed significant positive correlations with parental reports of illness severity. The majority of parents reported problems In relation to the symptom of scratching by their child with eczema. Recent problems with scratching were also found to correlate significantly with parenting stress. A rating scale was developed to allow parents to report on situational variables they associate with increased scratching by their child with eczema. The scale was found to have good test-retest reliability over a oneto-four week period. Three of its subscales (Environmental Sensitivity, Psychological Sensitivity and Negative Coping ) showed acceptable internal consistency. A fourth subscale (Positive Coping) showed poor internal consistency. Ratings on the Negative Coping subscale correlated significantly with parenting stress. A near-significant positive correlation was also found between parenting stress and the Psychological Sensitivity subscale. The methodological limitations of the study are discussed and implications for clinical practice and future research are outlined. The thesis also includes three small-scale research projects completetd during placements In Adult Mental Health, Learning Disabilities and Child and Adolescent services.

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Daehn, Ilse Sofia, and chickychulita@yahoo com. "Effect of growth factors on T-lymphocyte induced keratinocyte apoptosis." Flinders University. Department of Medicine-Biotechnology, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20071215.233705.

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Atopic eczema is a T-lymphocyte mediated chronic inflammatory skin disorder. The interaction of CD4+ T-lymphocytes with epidermal keratinocytes results in dysregulated, chronic inflammation and altered barrier function. T-lymphocyte induced keratinocyte apoptosis has been proposed as a mechanism by which epidermal integrity is impaired in eczema. Apoptosis of keratinocytes is thought to result from Tlymphocyte associated Fas ligand (FasL) binding to the death receptor Fas on keratinocytes. The primary aim of this project was to characterize the induction of keratinocyte apoptosis by T-lymphocytes and address the hypothesis that insulin-like growth factor-I (IGF-1), transforming growth factor [beta]1 (TGF[beta]1) and a milk derived growth factor extract containing TGF[beta] and IGF-I (whey growth factor extract; WGFE) protect keratinocytes from T-lymphocyte mediated apoptosis. To address the aims of this project, an in vitro co-culture model was developed combining T-lymphocytes with keratinocytes. Co-cultures were initially established using human Jurkat T-lymphocytes and human HaCaT keratinocytes with more extensive characterisation undertaken using primary CD4+ T-lymphocytes together with HaCaTs or normal human epidermal keratinocytes (NHEK). Annexin V and propidium iodide staining was established as the primary method for measuring keratinocyte apoptosis with this validated using sodium butyrate a known inducer of apoptosis. Changes in nuclear fragmentation and cell morphology were also examined as a key feature of apoptosis. The involvement of the Fas pathway was investigated by assessing T-lymphocyte FasL expression, keratinocyte Fas expression and downstream caspase activation. Inflammatory cytokines IFN[gamma] and TNF[alpha] were also examined due to their ability to induce Fas expression. Studies performed with T-lymphocytes demonstrated that keratinocyte apoptosis was induced, with this due primarily to direct T-lymphocytes and keratinocytes interactions, rather than soluble mediators in the co-culture milieu. Activated T-lymphocytes were found to have high levels of FasL and to upregulate keratinocyte Fas expression. The increased keratinocyte Fas was associated with increased IFN[gamma] levels in the co-culture media and activation of the caspase cascade. A Fas blocking antibody prevented T-lymphocyte induced keratinocyte apoptosis demonstrating that this was a Fas dependent event. As the primary function of keratinocytes is to terminally differentiate, the differentiation status of the cells induced to undergo apoptosis was examined. It was demonstrated that T-lymphocytes decrease the intensity of ?6 integrin expression by the keratinocytes. This marker identifies undifferentiated basal cells as high expressors of [alpha]6, with cells in the early stages of differentiation pathway found to be low expressors of [alpha]6. Co-staining with Annexin V demonstrated that the apoptotic keratinocytes were low expressors of [alpha]6 and thus cells committed to the early stages of differentiation. This suggested that the T-lymphocytes initiated the onset of keratinocyte terminal differentiation with this linked to the cells being more susceptible to death induced by T-lymphocyte by activation of the Fas pathway. The ability of TGF[beta]1, IGF-I and WGFE to inhibit T-lymphocyte induced keratinocyte apoptosis was examined. A combination of recombinant TGF[beta] (10ng) & IGF-I (100ng) was able to significantly inhibit keratinocyte apoptosis. A similar result was obtained with WGFE, and although these growth factor treatments were able to reduce the elevated IFN[gamma] levels in the co-culture media, they did not reduce T-lymphocyte induced Fas upregulation. The TGF?1 and IGF-I combination as well as WGFE did however prevent the T-lymphocyte induced shift from [alpha]6 bright to dim expressing keratinocytes. As such, the growth factor combinations appeared to protect the keratinocytes from T-lymphocyte mediated apoptosis by preventing them from committing to terminal differentiation. The studies in this thesis have characterised the Fas associated mechanisms by which T-lymphocytes induce keratinocyte apoptosis and suggest specific growth factor combinations may have the potential to ameliorate the reduced barrier function associated with inflammatory skin conditions such as atopic eczema.

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Chan, Hsien. "Investigation of the role of Der p 1 specific T cells in the pathogenesis of cutaneous atopic disease." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606283.

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Wei, Ru, and 韦茹. "Cumulative incidence of eczema and early life risk factors in the first 6 weeks of life: a birth cohort studyin Guangzhou." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46373342.

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DUCRET, DUMET ANNE. "L'allergie aux sparadraps." Nancy 1, 1993. http://www.theses.fr/1993NAN1P057.

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Rizova, Gueorguieva Elena. "Evenements precoces de l'hypersensibilite retardee : endocytose des molecules hla-dr par les cellules de langerhans humaines (doctorat : pharmacologie experimentale et clinique)." Paris 11, 1998. http://www.theses.fr/1998PA114852.

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梁耀國. "濕疹辨證論治規律的文獻研究." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/748.

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Chu, Roland Poh Cheong. "Role of filaggrin in skin barrier function and atopic dermatitis." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9964.

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Loss-of-function mutations in the filaggrin gene(FLG) have recently been shown to be strongly associated with atopic dermatitis (AD). The overall aim of this study was to explore the role of filaggrin in skin barrier function and AD. There were two main focuses in this study. The first was a functional study whose primary objective was to determine if FLG mutations correlated with skin barrier dysfunction in AD. Fifty-five mild to moderate AD individuals were recruited, genotyped and had their skin barrier assessed using three different measures - transepidermal water loss (TEWL), skin capacitance and the number of tape strips required to abrogate skin barrier. A secondary aim of this functional study was to test the hypothesis that corneocytes were less adherent to one another in filaggrin-related AD compared to wild-type AD skin. The second main focus of this thesis was a structural study aimed at interrogating the structure-function relationship of filaggrin. Filaggrin protein was extracted and purified from a total of 21 AD and non-AD subjects and analysed using mass spectrometric techniques. Specifically, matrix assisted laser desorption/ionisation time-of-flight(MALDI-TOF)mass spectrometry (MS) and nano liquid chromatography tandem MS(LC-MS/MS) were utilised. Part of this structural study also involved developing and optimising the extraction and purification of filaggrin protein, including a novel way of extracting filaggrin from skin using tape stripping. In addition, novel filaggrin-specific enzyme-linked immunosorbant assay (ELISA) was also developed, which could serve as a useful screening test for the protein. In this study, FLG mutations were found to correlate with higher TEWL and fewer number of tape strips required to abrogate skin barrier, but not with skin capacitance. FLG mutations were also not shown to correlate with AD severity. The mean amount of protein extracted from filaggrin-related AD skin was also significantly higher compared to wild-type AD skin, supporting the hypothesis that corneocytes were less adherent to one another (and therefore, densely packed) in filaggrin-related AD skin. MS analysis of filaggrin confirmed the heterogeneic nature of filaggrin protein, even within a single individual. Interestingly, this structural study also showed that filaggrin was only minimally expressed in the skin of all the AD individuals studied, whether or not they possessed any FLG mutation. Due to the limited amount of filaggrin extracted from AD skin, it was not possible to conduct comparative structural analysis between filaggrin from AD and non-AD skin.

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Dissertations / Theses on the topic 'Eczema'

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