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1

Du Toit, Riëtte, Phillip G. Herbst, Annari van Rensburg, Hendrik W. Snyman, Helmuth Reuter, and Anton F. Doubell. "Speckle tracking echocardiography in acute lupus myocarditis: comparison to conventional echocardiography." Echo Research and Practice 4, no. 2 (June 2017): 9–19. http://dx.doi.org/10.1530/erp-17-0005.

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Aims Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ventricular dysfunction in SLE patients, with limited research on its utility in clinical lupus myocarditis. We report on STE in comparison to conventional echocardiography in patients with clinical lupus myocarditis. Methods and results A retrospective study was done at a tertiary referral hospital in South Africa. SLE patients with lupus myocarditis were included and compared to healthy controls. Echocardiographic images were reanalyzed, including global longitudinal strain through STE. A poor echocardiographic outcome was defined as final left ventricular ejection fraction (LVEF) <40%. 28 SLE patients fulfilled the criteria. Global longitudinal strain correlated with global (LVEF: r = −0.808; P = 0.001) and regional (wall motion score: r = 0.715; P < 0.001) function. In patients presenting with a LVEF ≥50%, global longitudinal strain (P = 0.023), wall motion score (P = 0.005) and diastolic function (P = 0.004) were significantly impaired vs controls. Following treatment, LVEF (35–47% (P = 0.023)) and wall motion score (1.88–1.5 (P = 0.017)) improved but not global longitudinal strain. Initial LVEF (34%; P = 0.046) and global longitudinal strain (−9.5%; P = 0.095) were lower in patients with a final LVEF <40%. Conclusions This is the first known report on STE in a series of patients with clinical lupus myocarditis. Global longitudinal strain correlated with regional and global left ventricular function. Global longitudinal strain, wall motion score and diastolic parameters may be more sensitive markers of lupus myocarditis in patients presenting with a preserved LVEF ≥50%. A poor initial LVEF and global longitudinal strain were associated with a persistent LVEF <40%. Echocardiography is a non-invasive tool with diagnostic and prognostic value in lupus myocarditis.
2

Ahn, Chi Young. "Robust Myocardial Motion Tracking for Echocardiography: Variational Framework Integrating Local-to-Global Deformation." Computational and Mathematical Methods in Medicine 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/974027.

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This paper proposes a robust real-time myocardial border tracking algorithm for echocardiography. Commonly, after an initial contour of LV border is traced at one or two frames from the entire cardiac cycle, LV contour tracking is performed over the remaining frames. Among a variety of tracking techniques, optical flow method is the most widely used for motion estimation of moving objects. However, when echocardiography data is heavily corrupted in some local regions, the errors bring the tracking point out of the endocardial border, resulting in distorted LV contours. This shape distortion often occurs in practice since the data acquisition is affected by ultrasound artifacts, dropouts, or shadowing phenomena of cardiac walls. The proposed method is designed to deal with this shape distortion problem by integrating local optical flow motion and global deformation into a variational framework. The proposed descent method controls the individual tracking points to follow the local motions of a specific speckle pattern, while their overall motions are confined to the global motion constraint being approximately an affine transform of the initial tracking points. Many real experiments show that the proposed method achieves better overall performance than conventional methods.
3

Aniyathodiyil, Gopi, Sunil S. Bohra, Anup Mottengar, and Satish C. Govind. "Speckle-Tracking Echocardiography to Assess Global and Regional Left Ventricular Function in Acute Myocardial Infarction." Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging 1, no. 3 (2017): 177–84. http://dx.doi.org/10.4103/jiae.jiae_24_17.

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Speckle tracking is a useful tool in assessing global & regional myocardial function in patients with acute myocardial infarction undergoing primary PCI. Global Longitudinal Strain (GLS) is a robust parameter to assess regional and global LV function. Global longitudinal strain helps in predicting short term outcomes in these patients and has shown to be better than ejection fraction, and as good as wall motion scoring, wall motion scoring index and myocardial performance index. A Lower global longitudinal strain parallels the rise in troponin T and CPKMB in acute myocardial infarction. Global longitudinal strain may have the potential to be an echocardiographic parameter which is useful in identifying multivessel disease. Assessment of regional myocardial function by speckle tracking echocardiography, particularly GLS, can be useful in ACS patients undergoing PCI in predicting short term recovery of the affected segments. Speckle tracking echocardiography can be used independent of the conventional markers to assess regional and global LV function.
4

Hong, Gloria H., Allison G. Hays, and Nisha A. Gilotra. "The Evolving Role of Echocardiography During the Coronavirus Disease 2019 Pandemic." Heart International 16, no. 1 (2022): 28. http://dx.doi.org/10.17925/hi.2022.16.1.28.

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Coronavirus disease 2019 (COVID-19) has been associated with a wide spectrum of cardiovascular manifestations. Since the beginning of the pandemic, echocardiography has served as a valuable tool for triaging, diagnosing and managing patients with COVID-19. More recently, speckle-tracking echocardiography has been shown to be effective in demonstrating subclinical myocardial dysfunction that is often not detected in standard echocardiography. Echocardiographic findings in COVID-19 patients include left or right ventricular dysfunction, including abnormal longitudinal strain and focal wall motion abnormalities, valvular dysfunction and pericardial effusion. Additionally, some of these echocardiographic abnormalities have been shown to correlate with biomarkers and adverse clinical outcomes, suggesting an additional prognostic value of echocardiography. With increasing evidence of cardiac sequelae of COVID-19, the use of echocardiography has expanded to patients with cardiopulmonary symptoms after recovery from initial infection. This article aims to highlight the available echocardiographic tools and to summarize the echocardiographic findings across the full spectrum of COVID-19 disease and their correlations with biomarkers and mortality.
5

Piros, Györgyike Ágnes, Péter Domsik, Anita Kalapos, Csaba Lengyel, Andrea Orosz, Tamás Forster, and Attila Nemes. "A jobb pitvar és bal kamra méretének és funkciójának összefüggései egészségesekben. Eredmények a háromdimenziós speckle-tracking echokardiográfiás MAGYAR-Healthy Tanulmányból." Orvosi Hetilap 156, no. 24 (June 2015): 972–78. http://dx.doi.org/10.1556/650.2015.30133.

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Introduction: Heart cycle includes systole and diastole when heart chambers are characterized by a complex motion. Aim: The present study was designed to test whether relationships exist between three-dimensional speckle-tracking echocardiography-derived right atrial and routine two-dimensional echocardiography-derived left ventricular volumetric and functional parameters is healthy subjects. Method: The present study comprised 20 healthy volunteers. Complete two-dimensional echocardiography and three-dimensional speckle-tracking echocardiography were perfomed in all cases. Results: Left ventricular ejection fraction showed correlations with systolic and diastolic right atrial volumes and area strain characterzing atrial contraction in diastole. Right atrial volumes respecting cardiac cycle correlated only with left ventricular end-systolic diameter and volume, while similar relationships could not be confirmed with end-diastolic parameters. Conclusions: Relationships could be demonstrated between three-dimensional speckle-tracking echocardiography-derived right atrial and two-dimensional echocardiography-derived left ventricular volumetric and functional parameters in healthy subjects. Orv. Hetil., 2015, 156(24), 972–978.
6

Nesser, Hans Joachim. "Wall Motion Tracking and Activation Imaging – Latest Developments and Applications for Patients with Heart Failure." European Cardiology Review 8, no. 1 (2012): 51. http://dx.doi.org/10.15420/ecr.2012.8.1.51.

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Wall motion tracking is a relatively new tool to define regional and global wall motion, ventricular volumes and ejection fraction. Speckle-tracking echocardiography (STE) allows the calculation of a variety of myocardial function indices – including longitudinal, radial, transverse and circumferential strain, strain rate, displacement, velocity and rotation (twist and torsion) – not only as a 2D application, but also in 3D. In patients with heart failure and cardiac dyssynchrony, there remains a lack of optimal management regarding decisions to implant a cardiac resynchronisation therapy device. Many decisions are made based on data from electrocardiography. Whereas conventional echocardiographic techniques are of limited value in defining mechanical dyssynchrony, newer developments, such as 2D and 3D speckle tracking, have been shown to have significant potential to define the latest site of mechanical activation. Recent 3D STE innovations, including activation imaging, 3D strain and area tracking, open new doors to the definition of segmental delay of mechanical deformation related to time. There is considerable optimism that 3D techniques will improve the present understanding and treatment of patients with cardiac dyssynchrony.
7

SEO, Yoshihiro, Tomoko ISHIZU, Akiko ATSUMI, Ryo KAWAMURA, and Kazutaka AONUMA. "Cardiac wall motion analysis by three-dimensional speckle tracking echocardiography." Choonpa Igaku 41, no. 2 (2014): 155–63. http://dx.doi.org/10.3179/jjmu.jjmu.r.13.

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8

Enzensberger, C., J. Degenhardt, A. Tenzer, A. Doelle, and R. Axt-Fliedner. "First Experience with Three-Dimensional Speckle Tracking (3D Wall Motion Tracking) in Fetal Echocardiography." Ultraschall in der Medizin - European Journal of Ultrasound 35, no. 06 (August 20, 2014): 566–72. http://dx.doi.org/10.1055/s-0034-1384882.

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9

Туаева, Z. Tuaeva, Кириченко, and T. Kirichenko. "Clinical significance of myocardial strain in the patients with chd (literature review)." Journal of New Medical Technologies. eJournal 8, no. 1 (November 5, 2014): 0. http://dx.doi.org/10.12737/7363.

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2-D echocardiography is currently the first-line imaging modality for assessing global and regional function of left ventricle (LV). Using 2-D echocardiography, LV function is most often evaluated visually, as a result of the quality of the research depends directly on the experience and qualifications of the expert. The new technology of two-dimensional speckle tracking echocardiography allows to assessing the contractile function of the left ventricle quantitative. Over the years, the numerous studies have demonstrated the value of speckle tracking echocardiography in the diagnosis and risk stratification of a wide range of cardiac diseases, including coronary heart disease [14]. During the cardiac cycle the speckle tracking echocardiography allows in semi-automatic mode to evaluate the deformation of the myocardium in the three spatial directions: longitudinal, radial, and circular. In addition, speckle tracking estimates the direction of rotation and speed of motion of the left ventricular myocardium. This technology may have important clinical value for quick and accurate assessment of global and segmental myocardial function. The use of estimates of the deformation of the myocardium and the speed of deformation of the myocardium by means of speckle tracking method may be able to increase the sensitivity and precision of stenosing lesions of the coronary arteries [16].
10

Shiri, M., H. Behnam, H. Yeganegi, Z. A. Sani, and N. Nematollahi. "TRACKABLE-SPECKLE DETECTION USING A DUAL-PATH CONVOLUTIONAL NEURAL NETWORK FOR NODES SELECTION IN SPECKLE TRACKING ECHOCARDIOGRAPHY." Asian Journal Of Medical Technology 2, no. 2 (August 5, 2022): 33–54. http://dx.doi.org/10.32896/ajmedtech.v2n2.33-54.

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Speckle tracking echocardiography (STE) is widely used to quaantify regional motion and deformation of heart tissues. Before tracking, a segmentation step is first carried out, and only a set of nodes in the segmented model are tracked. However, a random selection of the nodes even after tissue segmentation could lead to an inaccurate estimation. In this paper, a convolutional neural network (CNN)-based method is presented to detect trackable speckle spots that have important properties of the texture for speckle tracking. The proposed CNN was trained and validated on 29500 ultrasound manually labelled image patches extracted from the echocardiography of 65 people. Using the proposed network, in silico experiments for automatic node selection were conducted to investigate the applicability of the proposed method in speckle tracking. The results were statistically highly significant (P<0.001) and demonstrated that the proposed method has the least tracking error among various existing methods.
11

Tyurina, L. G., L. T. Khamidova, N. V. Ryubalko, G. A. Gazaryan, and K. A. Popugaev. "Role of speckle-tracking echocardiography in diagnosis and further prognosis of coronary heart disease." Medical alphabet, no. 16 (October 19, 2023): 7–18. http://dx.doi.org/10.33667/2078-5631-2023-16-7-18.

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Echocardiography is one of the first-line methods of detection and evaluation of coronary artery disease, which helps clinicians in the diagnostic and prognostic evaluation of this disease. However, visual assessment of abnormal left ventricular myocardial wall motion is not always appropriate in detecting less severe or transient myocardial ischemia and in making an accurate differential diagnosis. Speckle-tracking echocardiography is a widely available non-invasive tool that can easily and quickly provide clarifying information and significantly extend the standard echocardiographic study, as the method allows you to identify subtle myocardial damage and local areas of ischemia that correspond to the pattern of coronary disease, and obtain an objective report in the form of simple visual scheme, very easy to use for differential diagnosis and treatment. Therefore, this method, which is increasingly used in various manifestations of coronary insufficiency and is convenient to use both at rest and with stress echocardiography, has proved efficient results in terms of predicting coronary heart disease, quantitative interpretation of emerging or persistent ischemia, assessment of the clinical course and outcome, and left ventricular remodeling. In this review, we have attempted to reflect the currently available findings that demonstrate the significance of speckle-tracking echocardiography for the evaluation and follow-up of coronary heart disease, including some congenital anomalies of the coronary arteries, and to touch on the main achievements and discoveries in the use of two-dimensional and three-dimensional deformation parameters and their potential application for a wider introduction into clinical practice.
12

Visentin, Silvia, Chiara Palermo, Martina Camerin, Luciano Daliento, Denisa Muraru, Erich Cosmi, and Luigi P. Badano. "Echocardiographic Techniques of Deformation Imaging in the Evaluation of Maternal Cardiovascular System in Patients with Complicated Pregnancies." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/4139635.

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Cardiovascular diseases (CVD) represent the leading cause of maternal mortality and morbidity. Knowledge of CVD in women is constantly evolving and data are emerging that female-specific risk factors as complications of pregnancy are conditions associated with an increased risk for the long-term development of CVD. Echocardiography is a safe and effective imaging technique indicated in symptomatic or asymptomatic pregnant women with congenital heart diseases who require close monitoring of cardiac function. Deformation imaging is an echocardiographic technique used to assess myocardial function by measuring the actual deformation of the myocardium through the cardiac cycle. Speckle-tracking echocardiography (STE) is a two-dimensional (2D) technique which has been found to be more accurate than tissue Doppler to assess both left ventricular (LV) and right ventricular (RV) myocardial function. The use of 2D STE however might present some technical issues due to the tomographic nature of the technique and the motion in the three-dimensional space of the myocardial speckles. This has promoted the use of 3D STE to track the motion of the speckles in the 3D space. This review will focus on the clinical value of the new echocardiographic techniques of deformation imaging used to assess the maternal cardiovascular system in complicated pregnancies.
13

Shahriar, Md Saqif, Tuhin Haque, Ashraf Ur Rahman, Hasanur Rahman, and Umme Shaila. "Strain Analysis Using Speckle Tracking Echocardiography for Detection of Coronary Artery Disease in Stable Angina Patients with No Regional Wall Motion Abnormality at Rest." Scholars Journal of Applied Medical Sciences 10, no. 10 (October 4, 2022): 1628–27. http://dx.doi.org/10.36347/sjams.2022.v10i10.008.

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Background: Speckle-tracking imaging is a novel method for assessing left ventricular (LV) function and ischemic changes. The aim of this study was to predict the presence of coronary artery disease by longitudinal 2D strain analysis using speckle tracking echocardiography in patients with stable or unstable angina with no regional wall motion abnormality at rest. Objectives: Objective of this study is to predict the presence of significant CAD in a patient with no regional wall motion abnormality by longitudinal 2D strain analysis using speckle tracking echocardiography. Methods: This cross-sectional study included a total 66 patients (mean age, 51.92±8.9 years) with suspected CAD without RWMA on resting echocardiography who underwent coronary angiography. Longitudinal 2D strain analysis by STE was performed in all patients before coronary angiography. Global and segmental peak systolic longitudinal strain (PSLS) were recorded & computed by offline dedicated software semi-automatically on bull’s-eye report. The patients were divided into two groups according to the coronary angiographic findings; group- I: significant CAD on coronary angiogram (n=35), group-II: normal coronaries on CAG (n=31).All the baseline characteristics and outcome were then compared between the two groups. Results: PSLSs of all left ventricular segments were obtained successfully in 66 patients. PSLS (both global and segmental) was significantly decreased in patients with significant CAD on CAG group. Receiver operating characteristic (ROC) curve analysis demonstrated that global PSLSs could effectively detect patients with CAD (area under ROC curve = 0.877, 95% CI=0.749–0.960). According to ROC curve analysis, -18.77% appeared to be a good cutoff value for predicting those with significant CAD (specificity 77.4% and sensitivity 82.9%). Conclusion: Global and segmental PSLS using speckle tracking echocardiography at rest was significantly lower in patients with CAD without RWMA, and might be useful for identifying patients with a significant CAD with good degree of sensitivity and specificity.
14

Sturmberger, Thomas, Johannes Niel, Josef Aichinger, and Christian Ebner. "Acute myocarditis with normal wall motion detected with 2D speckle tracking echocardiography." Echo Research and Practice 3, no. 1 (March 2016): K15—K19. http://dx.doi.org/10.1530/erp-16-0013.

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15

Zhang, Z., T. O’Meeghan, R. Anscombe, T. Boga, D. Luo, A. Morgan, S. Harding, P. Larsen, and A. Sasse. "Stress Echocardiography: Quantification and Identification of Ischaemic Wall Motion Through Speckle-tracking." Heart, Lung and Circulation 20 (January 2011): S191—S192. http://dx.doi.org/10.1016/j.hlc.2011.05.473.

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16

Axt-Fliedner, R., J. Degenhardt, A. Wolter, A. Kawecki, O. Graupner, and C. Enzensberger. "EP04.04: Feasibility of two-dimensional whole wall motion tracking in fetal echocardiography." Ultrasound in Obstetrics & Gynecology 46 (September 2015): 195–96. http://dx.doi.org/10.1002/uog.15542.

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17

Kleijn, Sebastiaan A., Mohamed FA Aly, and Otto Kamp. "The Future of Echocardiographic Left Ventricular Quantification – Towards Automated Assessment of Global and Regional Function in Four Dimensions." European Cardiology Review 7, no. 4 (2011): 241. http://dx.doi.org/10.15420/ecr.2011.7.4.241.

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Quantification of global and regional left ventricular (LV) function using echocardiography has significantly improved with evolving technology and development of more robust techniques. By building on the strengths and solving some of the limitations of techniques such as 2D speckle tracking imaging and 3D echocardiography, newly developed 3D speckle tracking offers a comprehensive quantitative evaluation of global and regional LV function, including assessment of dyssynchrony. Not only chamber indices such as LV volumes and ejection fraction, but also parameters directly assessing global and regional myocardial function such as strain and torsion can now be visualised and quantified in one fast analysis. Data on the validation and application of these parameters are quickly accumulating, demonstrating great promise for their clinical use – for example, for identification of regional wall motion abnormalities, assessment of dyssynchrony and prediction of response to cardiac resynchronisation therapy. In this regard, 3D speckle tracking echocardiography serves as a major stepping stone towards a robust fully automated assessment of global and regional LV function in the near future.
18

Pastore, Maria Concetta, Giulia Elena Mandoli, Francesco Contorni, Luna Cavigli, Marta Focardi, Flavio D’Ascenzi, Giuseppe Patti, Sergio Mondillo, and Matteo Cameli. "Speckle Tracking Echocardiography: Early Predictor of Diagnosis and Prognosis in Coronary Artery Disease." BioMed Research International 2021 (February 2, 2021): 1–11. http://dx.doi.org/10.1155/2021/6685378.

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Echocardiography represents a first level technique for the evaluation of coronary artery disease (CAD) which supports clinicians in the diagnostic and prognostic workup of these syndromes. However, visual estimation of wall motion abnormalities sometimes fails in detecting less clear or transient myocardial ischemia and in providing accurate differential diagnosis. Speckle tracking echocardiography (STE) is a widely available noninvasive tool that could easily and quickly provide additive information over basic echocardiography, since it is able to identify subtle myocardial damage and to localize ischemic territories in accordance to the coronary lesions, obtaining a clear visualization with a “polar map” useful for differential diagnosis and management. Therefore, it has increasingly been applied in acute and chronic coronary syndromes using rest and stress echocardiography, showing good results in terms of prediction of CAD, clinical outcome, left ventricular remodeling, presence, and quantification of new/residual ischemia. The aim of this review is to illustrate the current available evidence on STE usefulness for the assessment and follow-up of CAD, discussing the main findings on bidimensional and tridimensional strain parameters and their potential application in clinical practice.
19

Trache, Tudor, Stephan Stöbe, Adrienn Tarr, Dietrich Pfeiffer, and Andreas Hagendorff. "The agreement between 3D, standard 2D and triplane 2D speckle tracking: effects of image quality and 3D volume rate." Echo Research and Practice 1, no. 2 (November 2014): 71–83. http://dx.doi.org/10.1530/erp-14-0025.

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Comparison of 3D and 2D speckle tracking performed on standard 2D and triplane 2D datasets of normal and pathological left ventricular (LV) wall-motion patterns with a focus on the effect that 3D volume rate (3DVR), image quality and tracking artifacts have on the agreement between 2D and 3D speckle tracking. 37 patients with normal LV function and 18 patients with ischaemic wall-motion abnormalities underwent 2D and 3D echocardiography, followed by offline speckle tracking measurements. The values of 3D global, regional and segmental strain were compared with the standard 2D and triplane 2D strain values. Correlation analysis with the LV ejection fraction (LVEF) was also performed. The 3D and 2D global strain values correlated good in both normally and abnormally contracting hearts, though systematic differences between the two methods were observed. Of the 3D strain parameters, the area strain showed the best correlation with the LVEF. The numerical agreement of 3D and 2D analyses varied significantly with the volume rate and image quality of the 3D datasets. The highest correlation between 2D and 3D peak systolic strain values was found between 3D area and standard 2D longitudinal strain. Regional wall-motion abnormalities were similarly detected by 2D and 3D speckle tracking. 2DST of triplane datasets showed similar results to those of conventional 2D datasets. 2D and 3D speckle tracking similarly detect normal and pathological wall-motion patterns. Limited image quality has a significant impact on the agreement between 3D and 2D numerical strain values.
20

Enzensberger, Christian, Friederike Achterberg, Jan Degenhardt, Aline Wolter, Oliver Graupner, Johannes Herrmann, and Roland Axt-Fliedner. "Feasibility and Reproducibility of Two-Dimensional Wall Motion Tracking (WMT) in Fetal Echocardiography." Ultrasound International Open 03, no. 01 (February 9, 2017): E26—E33. http://dx.doi.org/10.1055/s-0042-124501.

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Hegeman, Romy R. M. J. J., Sean McManus, Jan-Peter van Kuijk, Serge C. Harb, Martin J. Swaans, Patrick Klein, and Rishi Puri. "Inward Displacement: A Novel Method of Regional Left Ventricular Functional Assessment for Left Ventriculoplasty Interventions in Heart Failure with Reduced Ejection Fraction (HFrEF)." Journal of Clinical Medicine 12, no. 5 (March 2, 2023): 1997. http://dx.doi.org/10.3390/jcm12051997.

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Background: Hybrid minimally invasive left ventricular reconstruction is used to treat patients with ischemic heart failure with reduced ejection fraction (HFrEF) and antero-apical scar. Pre- and post-procedural regional functional left ventricular assessment with current imaging techniques remains limited. We evaluated ‘inward displacement’ as a novel technique of assessing regional left ventricular function in an ischemic HFrEF population who underwent left ventricular reconstruction with the Revivent System. Methods: Inward displacement adopts three standard long-axis views obtained during cardiac MRI or CT and assesses the degree of inward endocardial wall motion towards the true left ventricular center of contraction. For each of the standard 17 left ventricular segments, regional inward displacement is measured in mm and expressed as a percentage of the maximal theoretical distance each segment can contract towards the centerline. The left ventricle was divided into three regions, obtaining the arithmetic average of inward displacement or speckle tracking echocardiographic strain at the left ventricular base (segments 1–6), mid-cavity (segments 7–12) and apex (segments 13–17). Inward displacement was measured using computed tomography or cardiac magnetic resonance imaging and compared pre- and post-procedurally in ischemic HFrEF patients who underwent left ventricular reconstruction with the Revivent System (n = 36). In a subset of patients who underwent baseline speckle tracking echocardiography, pre-procedural inward displacement was compared with left ventricular regional echocardiographic strain (n = 15). Results: Inward displacement of basal and mid-cavity left ventricular segments increased by 27% (p < 0.001) and 37% (p < 0.001), respectively, following left ventricular reconstruction. A significant overall decrease in both the left ventricular end systolic volume index and end diastolic volume index of 31% (p < 0.001) and 26% (p < 0.001), respectively, was detected, along with a 20% increase in left ventricular ejection fraction (p = 0.005). A significant correlation between inward displacement and speckle tracking echocardiographic strain was noted within the basal (R = −0.77, p < 0.001) and mid-cavity left ventricular segments (R = −0.65, p = 0.004), respectively. Inward displacement resulted in relatively larger measurement values compared to speckle tracking echocardiography, with a mean difference of absolute values of −3.33 and −7.41 for the left ventricular base and mid-cavity, respectively. Conclusions: Obviating the limitations of echocardiography, inward displacement was found to highly correlate with speckle tracking echocardiographic strain to evaluate regional segmental left ventricular function. Significant improvements in basal and mid-cavity left ventricular contractility were demonstrated in ischemic HFrEF patients following left ventricular reconstruction of large antero-apical scars, consistent with the concept of reverse left ventricular remodeling at a distance. Inward displacement holds significant promise in the HFrEF population being evaluated pre- and post-left ventriculoplasty procedures.
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Muntean, Iolanda, Mihaela Melinte, Amalia Făgărășan, Carmen Corina Șuteu, and Rodica Togănel. "A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension." Applied Sciences 12, no. 11 (May 28, 2022): 5494. http://dx.doi.org/10.3390/app12115494.

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Pulmonary arterial hypertension is a severe, progressive disease in children, that causes right ventricular dysfunction over time. Tissue motion annular displacement is a novel speckle-tracking derived echocardiographic parameter used in assessing ventricular function. The aim of our study was to determine the prognostic value of this echocardiographic parameter in children with pulmonary arterial hypertension. We conducted a case-control study by assessing twenty children with pulmonary arterial hypertension (idiopathic or secondary) and twenty age- and sex-matched controls, using clinical (WHO functional class, 6-min walking test), laboratory (brain natriuretic peptide level) and echocardiographic parameters (conventional and speckle-tracking derived tissue motion annular displacement) at enrolment and after one year of follow-up. According to their WHO functional class altering after one year, the pulmonary arterial hypertension patients were divided into two groups: non-worsening (eleven) and worsening (nine). The conventional echocardiographic parameters and all measured tricuspid tissue motion annular displacement indices (lateral, septal, midpoint and midpoint fractional displacement—TMADm%) were significantly lower in both pulmonary arterial hypertension groups (non-worsening and worsening) compared to controls. Comparing the worsening and non-worsening groups, only the TMADm% and brain natriuretic peptide level was significantly lower in worsening in comparison with non-worsening pulmonary arterial hypertension children (p = 0.010 and p = 0.018, respectively). In receiver-operating characteristic curve analysis, we found a cut-off value of 16.15% for TMADm% and a cut-off value of 34.35 pg/mL for the brain natriuretic peptide level that can predict worsening in pulmonary arterial hypertension children. In conclusion, tricuspid annulus midpoint fractional displacement, an angle-dependent speckle-tracking derived parameter, could be a good additional parameter in the assessment of the longitudinal right ventricular systolic function and in prediction of clinical worsening in children with pulmonary arterial hypertension.
23

Shen, Tao, Michael H. Picard, Lanqi Hua, Sara M. Burns, and Michael N. Andrawes. "Assessment of Tricuspid Annular Motion by Speckle Tracking in Anesthetized Patients Using Transesophageal Echocardiography." Anesthesia & Analgesia 126, no. 1 (January 2018): 62–67. http://dx.doi.org/10.1213/ane.0000000000002614.

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Zhang, Hua, Shaodong Qiu, Fei Chen, and Zhimin Zhu. "Three‐dimensional speckle‐tracking echocardiography for evaluating myocardial motion in patients with cardiorenal syndrome." Journal of Clinical Ultrasound 47, no. 7 (June 7, 2019): 412–18. http://dx.doi.org/10.1002/jcu.22749.

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25

Huang, Liqin, Xiangyu Zhang, and Wei Li. "Dense Trajectories and DHOG for Classification of Viewpoints from Echocardiogram Videos." Computational and Mathematical Methods in Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/9610192.

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In echo-cardiac clinical computer-aided diagnosis, an important step is to automatically classify echocardiography videos from different angles and different regions. We propose a kind of echocardiography video classification algorithm based on the dense trajectory and difference histograms of oriented gradients (DHOG). First, we use the dense grid method to describe feature characteristics in each frame of echocardiography sequence and then track these feature points by applying the dense optical flow. In order to overcome the influence of the rapid and irregular movement of echocardiography videos and get more robust tracking results, we also design a trajectory description algorithm which uses the derivative of the optical flow to obtain the motion trajectory information and associates the different characteristics (e.g., the trajectory shape, DHOG, HOF, and MBH) with embedded structural information of the spatiotemporal pyramid. To avoid “dimension disaster,” we apply Fisher’s vector to reduce the dimension of feature description followed by the SVM linear classifier to improve the final classification result. The average accuracy of echocardiography video classification is 77.12% for all eight viewpoints and 100% for three primary viewpoints.
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Evin, Morgane, Alban Redheuil, Gilles Soulat, Ludivine Perdrix, Golmehr Ashrafpoor, Alain Giron, Jérôme Lamy, et al. "Left atrial aging: a cardiac magnetic resonance feature-tracking study." American Journal of Physiology-Heart and Circulatory Physiology 310, no. 5 (March 1, 2016): H542—H549. http://dx.doi.org/10.1152/ajpheart.00504.2015.

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Importance of left atrial (LA) phasic function evaluation is increasingly recognized for its incremental value in terms of prognosis and risk stratification. LA phasic deformation in the pathway of normal aging has been characterized using echocardiographic speckle tracking. However, no data are available regarding age-related variations using feature-racking (FT) techniques from standard cine magnetic resonance imaging (MRI). We studied 94 healthy adults (41 ± 14 yr, 47 women), who underwent MRI and Doppler echocardiography on the same day for left ventricular (LV) diastolic function evaluation. From cine MRI, longitudinal strain and strain rate, radial motion fraction, and radial relative velocity, respectively, corresponding to the reservoir, conduit, and LA contraction phases, were measured using dedicated FT software. Longitudinal strain and radial motion fraction decreased gradually and significantly with aging for both reservoir ( r > 0.31, P < 0.003) and conduit ( r > 0.54, P < 0.001) phases, whereas they remained unchanged during the LA contraction phase. Subsequently, the LA contraction-to-reservoir ratio increased significantly with age ( r > 0.44, P < 0.001). Longitudinal strain rate and radial relative velocity significantly decreased with age (reservoir: r = 0.39, P < 0.001, conduit: r > 0.54, P < 0.001), and these associations tended to be stronger in women than in men. Finally, associations of LA functional indexes with age were stronger in individuals with lower transmitral early-to-atrial maximal velocity ratio and mitral annulus maximal longitudinal velocity, as well as higher transmitral early maximal-to-mitral annulus maximal longitudinal velocity ratio, highlighting the LV-LA interplay. Age-related changes in LA phasic function indexes were quantified by cine MRI images using a FT technique and were significantly related to age and LV diastolic function.
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Dietenbeck, T., D. Barbosa, M. Alessandrini, R. Jasaityte, V. Robesyn, J. D’hooge, D. Friboulet, and O. Bernard. "Whole myocardium tracking in 2D-echocardiography in multiple orientations using a motion constrained level-set." Medical Image Analysis 18, no. 3 (April 2014): 500–514. http://dx.doi.org/10.1016/j.media.2014.01.005.

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Enzensberger, Christian, Friederike Achterberg, Oliver Graupner, Aline Wolter, Johannes Herrmann, and Roland Axt-Fliedner. "Wall-motion tracking in fetal echocardiography-Influence of frame rate on longitudinal strain analysis assessed by two-dimensional speckle tracking." Echocardiography 34, no. 6 (April 10, 2017): 898–905. http://dx.doi.org/10.1111/echo.13542.

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Nemes, Attila, and Tamás Forster. "Evaluation of left atrial size and function – from M-mode to 3D speckle-tracking echocardiography." Orvosi Hetilap 155, no. 41 (October 2014): 1624–31. http://dx.doi.org/10.1556/oh.2014.30007.

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Left atrium is not a passive heart chamber, because it has a dynamic motion respecting heart cycle and, in accordance with its stretching, it releases atrial natriuretic peptides. Since in the course of certain invasive procedures the size of left atrium may change substantially, its exact measurement and functional characterization are essential. The aim of the present review is to summarize echocardiographic methods for the assessment of left atrial size and functional parameters. Orv. Hetil., 2014. 155(41), 1624–1631.
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Amuthan, V., and R. V. A. Ananthcal. "Journey from Two-Dimensional to Four-Dimensional Strain and Left Ventricle Torsion in the Evaluation of Coronary Artery Disease." Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging 1, no. 3 (2017): 189–96. http://dx.doi.org/10.4103/jiae.jiae_39_17.

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The use of echocardiography in the diagnosis of suspected myocardial infarction has been classified as appropriate. The use of regional strain which is a dimensionless measurement of deformation, expressed as a fractional or percentage change from an object's original dimension, greatly enhances the accuracy of detecting the regional wall motion abnormality in a scale (-20 to +20) ten times that of eye balling. Speckle-tracking echocardiography (STE) is a novel technique which has emerged as one of the best methods that analyses motion and strain by tracking natural acoustic reflections and interference patterns within an ultrasonic window. In patients with acute myocardial infarctions (MIs), accuracy for the prediction of global functional improvement as well as LV remodelling by 2D STE is comparable with that of late gadolinium enhancement cardiac magnetic resonance (CMR) imaging. Global longitudinal strain (GLS) has evolved as one of the most robust parameter, and this has been shown to identify subclinical LV dysfunction.3D STE has emerged as an alternative non -invasive technique to assess LV rotation. In anterior wall myocardial infarction, systolic twist is decreased, and diastolic untwisting is depressed in accordance with LV systolic dysfunction. These results suggest the significant impact of global LV systolic function on LV twist and twist-displacement loops in patients with anterior wall MI. Although to date, no prognostic information exists on the role of rotational parameters of LV function, further ongoing studies would shed more light on this important technique.
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Arita, Takeshi, George P. Sorescu, Brian T. Schuler, Laura S. Schmarkey, John D. Merlino, Jakob Vinten-Johansen, Angel R. Leon, Randolph P. Martin, and Dan Sorescu. "Speckle-tracking strain echocardiography for detecting cardiac dyssynchrony in a canine model of dyssynchrony and heart failure." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 1 (July 2007): H735—H742. http://dx.doi.org/10.1152/ajpheart.00168.2007.

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Multiple echocardiographic criteria have been proposed to diagnose mechanical dyssynchrony in patients with heart failure without being validated against a model of cardiac dyssynchrony with heart failure. This study examines which of these methods can detect dyssynchrony in a canine model. Adult mongrel dogs underwent His-bundle ablation and right-ventricular pacing for 4 wk at either 110 bpm to induce dyssynchrony without heart failure (D group, n = 12) or 170 bpm to induce dyssynchrony with heart failure (DHF group, n = 9). To induce heart failure with narrow QRS, atria were paced at 190 bpm for 4 wk (HF group, n = 8). Tissue Doppler imaging (TDI) and two-dimensional echocardiography were performed at baseline and at end of study. Standard deviation of time to peak systolic velocity (color-coded TDI), time to peak S wave on pulse-wave TDI, time to peak radial and circumferential strain by speckle-tracking analysis ( Err and Ecc, respectively), and septal-to-posterior wall motion delay on M mode were obtained. In D group, only Err and Ecc were increased by dyssynchrony. In contrast, all the echocardiographic parameters of dyssynchrony appeared significantly augmented in the DHF group. Receiver-operator curve analysis showed good sensitivity of Err (90%) and Ecc (100%) to detected dyssynchrony without heart failure and excellent sensitivity and specificity of Err and Ecc to detect dyssynchrony with heart failure. Radial strain by speckle tracking is more accurate than TDI velocity to detect cardiac dyssynchrony in a canine model of dyssynchrony with or without heart failure.
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Sascău, Radu, Ioana Mădălina Zota, Cristian Stătescu, Daniela Boișteanu, Mihai Roca, Alexandra Maștaleru, Maria Magdalena Leon Constantin, Teodor Flaviu Vasilcu, Radu Sebastian Gavril, and Florin Mitu. "Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea." Canadian Respiratory Journal 2018 (November 18, 2018): 1–9. http://dx.doi.org/10.1155/2018/1206217.

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Obstructive sleep apnea (OSA) causes recurrent apneas due to upper respiratory tract collapse, leading to sympathetic nervous system hyperactivation and increased cardiovascular risk. Moderate and severe forms of obstructive sleep apnea are associated with increased atrial volumes and affect left ventricular diastolic and then systolic function. Right ventricular ejection fraction can be accurately assessed via three-dimensional echocardiography, while bidimensional imaging can only provide a set of surrogate parameters to characterize systolic function (tricuspid annulus plane systolic excursion, right ventricular fractional area change, and lateral S’). Tissue Doppler imaging is a more sensitive tool in detecting functional ventricular impairment, but its use is limited by angle dependence and the unwanted influence of tethering forces. Two-dimensional speckle tracking echocardiography is considered more suitable for the assessment of ventricular function, as it is able to distinguish between active and passive wall motion. Abnormal strain values, a marker of subclinical myocardial dysfunction, can be detected even in patients with normal ejection fraction and chamber volumes. The left ventricular longitudinal strain is more affected by the presence of obstructive sleep apnea than circumferential strain values. Although the observed OSA-induced changes are subtle, the benefit of a detailed echocardiographic screening for subclinical heart failure in OSA patients on therapy adherence and outcome should be addressed by further studies.
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Gjesdal, Ola, Einar Hopp, Trond Vartdal, Ketil Lunde, Thomas Helle-Valle, Svend Aakhus, Hans-Jørgen Smith, Halfdan Ihlen, and Thor Edvardsen. "Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease." Clinical Science 113, no. 6 (August 13, 2007): 287–96. http://dx.doi.org/10.1042/cs20070066.

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2D-STE (two-dimensional speckle tracking echocardiography) is a novel echocardiographic modality that enables angle-independent assessment of myocardial deformation indices. In the present study, we tested whether peak systolic ϵ∥ (longitudinal strain) values measured by 2D-STE could identify areas of MI (myocardial infarction) as determined by CE MRI (contrast-enhanced magnetic resonance imaging). Conventional echocardiographic apical long-axis recordings were performed in 38 patients, 9 months after a first MI. Peak systolic ϵ∥ measured by 2D-STE in 16 left ventricle segments was compared with segmental infarct mass and transmurality assessed by CE MRI. Segmental values were averaged to global and territorial values for assessment of global function and myocardial function in the coronary distribution areas. CE MRI identified transmural infarction in 27 patients, and a mean infarct size of 36±25 g. Peak systolic ϵ∥ correlated with the infarct mass at the global level (r=0.84, P<0.001). A strain value of −15% identified infarction with 83% sensitivity and 93% specificity at the global level and 76% and 95% at the territorial level, and a strain value of −13% identified transmural infarction with 80% sensitivity and 83% specificity at the segmental level. Global infarct mass correlates with the wall motion score index (r=0.70, P<0.001), and left ventricular ejection fraction measured by MRI or echocardiography (r=−0.71 and −0.58, both P<0.001). In chronic infarction, peak systolic ϵ∥ measured by 2D-STE correlates with the infarct mass assessed by CE MRI at a global level, and separates infarcted from non-infarcted tissue. Global strain is an excellent predictor of myocardial infarct size in chronic ischaemic heart disease.
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Enzensberger, Christian, Laura Rostock, Oliver Graupner, Malena Götte, Aline Wolter, Carina Vorisek, Johannes Herrmann, and Roland Axt‐Fliedner. "Wall motion tracking in fetal echocardiography—Application of low and high frame rates for strain analysis." Echocardiography 36, no. 2 (December 25, 2018): 386–93. http://dx.doi.org/10.1111/echo.14238.

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Eto, Yoko, Hirotsugu Yamada, Joon-Han Shin, Deborah A. Agler, Hiroyuki Tsujino, Jian-Xin Qin, Giuseppe Saracino, Neil L. Greenberg, James D. Thomas, and Takahiro Shiota. "Automated mitral annular tracking: A novel method for evaluating mitral annular motion using two-dimensional echocardiography." Journal of the American Society of Echocardiography 18, no. 4 (April 2005): 306–12. http://dx.doi.org/10.1016/j.echo.2004.11.001.

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Henein, Michael Y., and Per Lindqvist. "Assessment Of Left Ventricular Diastolic Function By Doppler Echocardiography." Cardiac Failure Review 1, no. 2 (2015): 87. http://dx.doi.org/10.15420/cfr.2015.1.2.87.

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Diastole is an essential part of the cardiac cycle, during which significant changes in myocardial function, ion and energy transfer, as well as coronary flow, occur. In contrast to systole, diastole consists of four phases, each of which has its distinguishing function and events. However, the four phases are inter-related with events in early diastole correlating with those in late diastole and those occurring during the isovolumic relaxation time predicting both. The complexity of diastolic phases is reflected in the ways by which diastolic function is assessed. While intra-cardiac flow velocities, into and out of the atria, are measured by pulsed-wave Doppler, those of wall motion are assessed by M-mode, myocardial Doppler velocities or, recently, speckle tracking technique. Optimum integration of various aspects of diastolic function should always be considered in order to obtain an accurate comprehensive assessment, bearing in mind factors that normally affect it, for example age.
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Saputro, Adhi Harmoko, M. Marzuki Mustafa, Aini Hussain, W. Mimi Diyana W. Zaki, Oteh Maskon, and Ika Faizura Mohd Nor. "GLOBAL FEATURE FOR LEFT VENTRICULAR DYSFUNCTION DETECTION BASED ON SHAPE DEFORMATION TRACKING." Biomedical Engineering: Applications, Basis and Communications 27, no. 02 (March 17, 2015): 1550017. http://dx.doi.org/10.4015/s1016237215500179.

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Left ventricular (LV) shape alteration is closely correlated with cardiac disease and LV function. In this paper, we propose a feature to detect LV dysfunction globally by analyzing the LV shape deformation in systolic contraction. The feature is an index that is extracted from geometric measurement of LV shape such as the length of the long axis, the short axis, and the apical diameter. A framework for computing the features is also proposed that consists of shape model construction and motion estimation of myocardial boundary. The LV shape model is extracted from apical 2 and 4 chamber views of 2D echocardiography. The long axis, the short axis, and the apical diameter were redefined according to the LV shape constructed. An optical flow technique was used to estimate the position of the LV boundary in each frame. The classification of the LV dysfunction was performed using linear discriminant analysis (LDA) and neural networks (NNs). The 2D echocardiography dataset collected from routine clinical check-up were used to validate the proposed method by comparing the computation result and cardiac expert diagnose. Classification performance and statistical analysis, which was performed to discriminate between healthy and diseased data, indicated promising results. The global LV features would provide a strong basis for a global LV function diagnosis and a global cardiac pathology assessment.
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Haque, Tuhin. "Myocardial Strain Imaging Using Two and Three-Dimensional Speckle Tracking Echocardiography: Clinical Applications." Cardiovascular Journal 11, no. 2 (February 27, 2019): 167–82. http://dx.doi.org/10.3329/cardio.v11i2.40418.

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Cardiac function analysis is the main focus of echocardiography. Myocardial strain & strain rate imaging have emerged as a quantitative technique to accurately estimate myocardial function. In the last decade, two dimensional speckle tracking echocardiography (2DSTE) has gained popularity as a novel technique for strain & strain rate measurement. This technique has been found clinically useful in the assessment of cardiac systolic & diastolic function. 2D strain could potentially be used to differentiate disease from nondisease segments, for identifying early subclinical changes in various pathologies and to learn more about the various strain patterns indicative of specific disease types. A large number of studies have evaluated the role of 2DSTE in predicting the response to cardiac resynchronization therapy in patients with severe heart failure. Emerging areas of applications of 2DSTE include prediction of rejection in heart transplant patients, early detection of cardiotoxicity in patients receiving chemotherapy for cancer and effect of intracoronary injection of bone marrow stem cells on left ventricular function in patients with acute myocardial infarction. However, 2D imaging methods have limitations in assessing three dimensional (3D) cardiac motion. Experimental studies and clinical investigations revealed the reliability and feasibility of 3DSTE-derived data. In this review, the methodology, validation, and clinical application of both 2D &3DSTE have been discussed. Cardiovasc. j. 2019; 11(2): 167-182
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Paul, Protap Kumar, Muhammed Towhidul Ahsan Khan, S. M. Sharif Uddin Pathan, Md Kamrul Hasan, Nure Alam Siddique, Mohammad Alwalid Sharkar, Ashish Kumar Roy, and Md Shahadat Md Shahadat. "Associations between ECG Changes and Echocardiographic Findings in Patients with Acute Non-ST Elevation Myocardial Infarction." Scholars Journal of Applied Medical Sciences 11, no. 10 (October 10, 2023): 1787–90. http://dx.doi.org/10.36347/sjams.2023.v11i10.004.

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Background: STEMI shows specific ECG changes due to sudden coronary blockage, but NSTEMI has varied ECG characteristics, including ST depressions and T wave inversions. Echocardiography, especially tissue Doppler imaging and speckle tracking, is crucial for diagnosing and predicting outcomes in acute coronary syndrome. The study aims to correlate ECG changes with echocardiographic findings in NSTEMI, offering potential diagnostic insights. Objective: The study aims to connect ECG alterations with echocardiographic findings in NSTEMI patients. Methods and Materials: This cross-sectional study took place from January to June 2023 at a Mymensingh Medical College Hospital, Mymensingh, Bangladesh. The research included 109 NSTEMI patients, both with and without cardiac history. Inclusion criteria were age above 30 and ischemic type of chest pain. Results: Out of 109 admitted patients, 67.4% were male and 6.4% were female. The average age was 54.34 ± 2.31 years, and prevalent conditions included 7.3% with diabetes, 11% with dyslipidemia, and 0.9% with edema, while 73% had a family history of ischemia. Conclusion: There were inconsistencies between the ECG and Echo in identifying the site of the infraction in the MI patients. Pulmonary hypertension, infection, ischemic stroke, and inferonasal regional wall motion abnormalities. Maximum no association was found in ECG changes and echocardiographic findings with acute non-ST elevation myocardial infarction.
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Dydenko, Igor, Fadi Jamal, Olivier Bernard, Jan D’hooge, Isabelle E. Magnin, and Denis Friboulet. "A level set framework with a shape and motion prior for segmentation and region tracking in echocardiography." Medical Image Analysis 10, no. 2 (April 2006): 162–77. http://dx.doi.org/10.1016/j.media.2005.06.004.

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Silverman, Norman H. "Echocardiographic presentation of anomalous origin of the left coronary artery from the pulmonary artery." Cardiology in the Young 25, no. 8 (December 2015): 1512–23. http://dx.doi.org/10.1017/s1047951115002565.

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AbstractIn the 1970s, diagnosing anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) was often uncertain using imaging alone; however, with the advances in high-frequency transducers, advanced image processing, and other ultrasound modalities such as Doppler colour flow imaging, tissue Doppler imaging, and speckle tracking to asses regional wall motion abnormalities, modern echocardiography now permits accurate diagnosis of ALCAPA with greater certainty. Although many consider ultrasound to be the only imaging test necessary if there is a question as to the diagnosis, other imaging modalities such as MRI, CT, and cardiac catheterisation with angiography remain valuable complementary tests, especially in older patients.
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Habeeb, Nevin Mohamed, Omneya Ibrahim Youssef, Waleed Mohamed Elguindy, Ahmed samir Ibrahim, and Walaa Hamed Hussein. "Three Dimensional (3D) Echocardiography as a Tool of Left Ventricular Assessment in Children with Dilated Cardiomyopathy: Comparison to Cardiac MRI." Open Access Macedonian Journal of Medical Sciences 6, no. 12 (November 25, 2018): 2310–15. http://dx.doi.org/10.3889/oamjms.2018.270.

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BACKGROUND: Left ventricular (LV) volumes and ejection fraction (EF) is Strong prognostic indicators for DCM. Cardiac MRI (CMRI) is a preferred technique for LV volumes and EF assessment due to high spatial resolution and complete volumetric datasets. Three-dimensional echocardiography is a promising new technique under investigations. AIM: Evaluate 3D echocardiography as a tool in LV assessment in DCM children about CMRI. PATIENTS AND METHODS: A group of 20 DCM children (LVdiastolic diameter < 2 Z score, LVEF < 35%) at Children s Hospital, Ain-Shams University (gp1) (mean age 6.6 years) were compared to 20 age and sex-matched children as controls (gp2). Patients were subjected to: clinical examination, conventional echocardiography, automated 3D LV quantification, 3D speckle tracking echocardiography (3D-STE) (VIVID E9 Vingmed, Norway) and CMRI (Philips Achieva Nova, 1.5 Tesla scanner) for LV end systolic volume (LVESV), LVend diastolic volume (LVEDV) that were indexed to body surface area, EF% and wall motion abnormalities assessment. RESUTS: No statistically significant difference was found between automated 3D LV quantification echocardiography, 3D-STE, and CMRI in ESV/BSA and EDV/BSA assessment (p = 1, 0.99 respectively), between automated LV quantification echocardiography and CMRI in EF% assessment (p = 0.99) and between CMRI and 3D-STE in LV Global hypokinesia detection (P = 0.255). As for segmental hypokinesia CMRI was more sensitive [45% of patients vs. 40%, (P = 0,036), basal septal hypokinesia 85% vs. 75%, (p = 0.045), mid septal hypokinesia 80% vs. 65%, (p = 0.012) and lateral wall hypokinesia 75% vs. 65%, (p = 0.028)]. CONCLUSION: Automated 3D LV quantification echocardiography and 3D-STE are reliable tools in LV volumetric and systolic function assessment about CMRIas a standard method. 3D speckle echocardiography is comparable to CMRI in global wall hypokinesia detection but less sensitive in segmental wall hypokinesia which mandates further studies.
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Black, David E., Jen Bryant, Charles Peebles, Keith M. Godfrey, Mark Hanson, and Joseph J. Vettukattil. "Tissue motion annular displacement of the mitral valve using two-dimensional speckle tracking echocardiography predicts the left ventricular ejection fraction in normal children." Cardiology in the Young 24, no. 4 (June 27, 2013): 640–48. http://dx.doi.org/10.1017/s1047951113000863.

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AbstractBackground: The gold standard for determining the left ventricular ejection fraction is cardiac magnetic resonance imaging. Other parameters for determining the ejection fraction such as M-mode echocardiography are operator-dependant and often inaccurate. Assessment of the displacement of the mitral valve annulus using two-dimensional speckle tracking echocardiography may provide an accurate and simple method of determining the left ventricular ejection fraction in children. Method: We retrospectively studied 70 healthy 9-year-old children with no history of cardiovascular disease who had been assessed using cardiac magnetic resonance imaging and two-dimensional transthoracic echocardiography. Mitral displacement was determined using the tissue motion annular displacement (TMAD) feature of Philips QLAB version 9. The midpoint displacement of the mitral valve was calculated, and the predicted left ventricular ejection fraction was compared with magnetic resonance imaging-derived and M-mode-derived ejection fractions. Results: The mean ejection fraction derived from magnetic resonance imaging (64.5 (4.6)) was similar to that derived from the TMAD midpoint (60.9 (2.7), p = 0.001) and the M-mode (61.9 (7), p = 0.012). The TMAD midpoint correlated strongly with the magnetic resonance imaging-derived ejection fraction (r = 0.69, p < 0.001), as did the predicted fraction (r = 0.67, p < 0.001). The M-mode ejection fraction showed a poor linear correlation with both magnetic resonance imaging-derived and TMAD-derived fractions (r = 0.33 and 0.04, respectively). Conclusion: TMAD of the mitral valve is a simple, effective, and highly reproducible method of assessing the ejection fraction in normal children. It shows a strong linear correlation with magnetic resonance imaging-derived ejection fraction and is superior to M-mode-derived ejection fractions.
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Hsiao, Ju-Feng, Kuo-Li Pan, Chi-Ming Chu, Shih-Tai Chang, Chang-Min Chung, and Jen-Te Hsu. "Usefulness of serial post-systolic shortening by speckle tracking echocardiography to predict major adverse cardiovascular events and segmental function improvement after acute myocardial infarction." PLOS ONE 15, no. 12 (December 31, 2020): e0244589. http://dx.doi.org/10.1371/journal.pone.0244589.

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Purpose The aim is to determine whether serial post-systolic shortening (PSS) using speckle tracking echocardiography (STE) could predict major adverse cardiovascular events (MACE), especially symptom-driven infarct-related artery (IRA) revascularization and improvement in segmental function in post-myocardial infarction patients. Methods/Results Ninety-four patients (average age 61.1 ± 12.5 y, 84 [84.9%] male) with new-onset acute myocardial infarction were enrolled. Serial echocardiography was performed during the initial presentation, and at 3, 6 and 12 months after admission. PSS, strain and systolic strain rate were calculated using STE. Improvement in segmental function was defined as a decrease of ≧1 grade in wall motion score. During the follow-up (29.4 ± 12.7months), 22 patients (23.4%) had MACE and 17 patients had symptom-driven IRA revascularization. In multivariate model, PSS at 3 months was independently predictive for symptom-driven IRA revascularization (Hazard ratio (HR) = 0.5, 95% CI = 0.26–0.97) and for MACE (HR = 0.4, 95% CI = 0.24–0.67) (p < 0.05). Segmental function improvements were found in 255 segments (66.1%) and ROC curve analyses showed that AUC (95% CI) of the initial PSS was 0.7(0.65–0.77) (cut-off values = -1.08, sensitivity = 58%, specificity = 73% specificity). Conclusions Post-systolic shortening at 3 months is an independent predictor for symptom-driven IRA revascularization and MACE. Regional wall motion recovery also could be predicted by initial PSS. Serial assessment of two-dimensional STE should be investigated in post-myocardial infarction patients in the future.
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Rodriguez-Zanella, Hugo, Rosina Arbucci, Juan Francisco Fritche-Salazar, Xochitl Arely Ortiz-Leon, Domenico Tuttolomondo, Diego Haber Lowenstein, Karina Wierzbowska-Drabik, et al. "Vasodilator Strain Stress Echocardiography in Suspected Coronary Microvascular Angina." Journal of Clinical Medicine 11, no. 3 (January 28, 2022): 711. http://dx.doi.org/10.3390/jcm11030711.

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Background: In patients with Ischemia and non-obstructive coronary artery stenosis (INOCA) wall motion is rarely abnormal during stress echocardiography (SE). Our aim was to determine if patients with INOCA and reduced coronary flow velocity reserve (CVFR) have altered cardiac mechanics using two-dimensional speckle-tracking echocardiography (2DSTE) during SE. Methods: In a prospective, multicenter, international study, we recruited 135 patients with INOCA. Overall, we performed high dose (0.84 mg/kg) dipyridamole SE with combined assessment of CVFR and 2DSTE. The population was divided in patients with normal CVFR (>2, group 1, n = 95) and abnormal CVFR (≤2, group 2, n = 35). Clinical and 2DSTE parameters were compared between groups. Results: Feasibility was high for CFVR (98%) and 2DSTE (97%). A total of 130 patients (mean age 63 ± 12 years, 67 women) had complete flow and strain data. The two groups showed similar 2DSTE values at rest. At peak SE, Group 1 patients showed lower global longitudinal strain (p < 0.007), higher mechanical dispersion (p < 0.0005), lower endocardial (p < 0.001), and epicardial (p < 0.0002) layer specific strain. Conclusions: In patients with INOCA, vasodilator SE with simultaneous assessment of CFVR and strain is highly feasible. Coronary microvascular dysfunction is accompanied by an impairment of global and layer-specific deformation indices during stress.
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Yang, Hyun Suk, Farouk Mookadam, Bijoy K. Khandheria, and Krishnaswamy Chandrasekaran. "Right Ventricular Segmental Rotation and Torsion in Normal Subjects on 2D Speckle Tracking Echocardiography." Clinical Ultrasound 7, no. 2 (November 30, 2022): 95–102. http://dx.doi.org/10.18525/cu.2022.7.2.95.

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Background/Aims: Little is known about the complex anatomy of right ventricular (RV) torsion in the general population. This study was designed to assess RV’s global and segmental torsional motion in subjects without cardiac pathologies.Methods: We used the Vivid 7 ultrasound system (GE Healthcare, Chicago, IL, USA) to acquire parasternal short-axis views of the RV at the basal and apical levels, and analyzed global and segmental torsion using a 2D speckle tracking algorithm in EchoPAC workstation (GE Healthcare, Wauwatosa, WI, USA).Results: Forty-eight individuals (44 ± 17 years, 54% male) were included, with either normal left ventricular diastolic function (group I, n = 40) or grade I diastolic dysfunction (group II, n = 8). Group I showed global peak systolic torsion of 9.0 ± 6.6 degrees with higher segmental torsion in the mid-interventricular septum (IVS) than in the anterior walls (<i>p</i> = 0.001). Global RV torsion showed a very strong positive correlation with apical rotation (r = 0.91, <i>p</i> < 0.001). Group I exhibited higher segmental torsion in the anterior-IVS and mid-IVS walls than group II (9.8 ± 7.1 vs. 3.5 ± 9.6 degrees, <i>p</i> = 0.036; 10.4 ± 9.1 vs. 2.4 ± 12.3 degrees, <i>p</i> = 0.038, respectively).Conclusions: Analysis of RV segmental torsion was feasible using a 2D speckle tracking algorithm. Apical rotation can be used as a simplified index of global RV torsion. Further studies are needed to evaluate the clinical impact of RV torsion in various pathologies.
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Derpa, Vivian F., Raphael Koch, Mareike Möllers, Kerstin Hammer, Kathrin Oelmeier de Murcia, Helen A. Köster, Maria K. Falkenberg, Janina Braun, Walter Klockenbusch, and Ralf Schmitz. "Comparison of Longitudinal and Apical Foetal Speckle Tracking Echocardiography Using Tissue Motion Annular Displacement and Segmental Longitudinal Strain." Ultrasound in Medicine & Biology 45, no. 1 (January 2019): 233–45. http://dx.doi.org/10.1016/j.ultrasmedbio.2018.09.013.

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van Mourik, Manouk J. W., Daniëlle V. J. Zaar, Martijn W. Smulders, Jordi Heijman, Joost Lumens, Jeffrey E. Dokter, Valeria Lima Passos, et al. "Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction." Journal of the American Society of Echocardiography 32, no. 1 (January 2019): 65–73. http://dx.doi.org/10.1016/j.echo.2018.09.007.

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Andova, Valentina, Ljubica Georgievska-Ismail, Elizabeta Srbinovska, and Biljana Janeska. "Does the Presence of Diabetes Mellitus Make a Difference in Pharmacological Stress Echocardiography Outcome Results?" Open Access Macedonian Journal of Medical Sciences 6, no. 11 (November 20, 2018): 2084–90. http://dx.doi.org/10.3889/oamjms.2018.452.

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Abstract:
BACKGROUND: Coronary artery disease (CAD) is the leading cause of mortality and morbidity in patients with diabetes (DM). AIM: Тhe aim of our study was to analyse the ability of pharmacological SE to risk stratify patients with DM using qualitative and quantitative assessment of LV function. METHODS: We prospectively assessed 105 consecutive patients (58.7 ± 9.5 y, 39 male) with known or suspected CAD who underwent dipyridamole or dobutamine SE. RESULTS: Change of systolic LV function at maximal SE was less pronounced in patients with DM, while parameters of the diastolic function and its change with stress were almost insignificant. WMSI in comparison to GLS% didn’t make a difference in SE outcome regarding DM presence. WMSI was almost unchanged at maximal stress in diabetic patients. Conversely, GLS% showed significant worsening at maximal stress in diabetic patients. However, only WMSI at maximal stress along with DM presence appeared as independent predictors of the presence of new and worsening CAD during SE. Longitudinal strain assessed using speckle tracking during pharmacological stress echocardiography was superior to conventional echocardiography expressed by wall motion analysis in making a difference regarding DM presence. CONCLUSION: We confirmed the usefulness of stress echocardiography using qualitative and/or quantitative parameters in the detection of CAD in patients with DM.
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Matos, Jorge Isidoro, Sara Nieves García-Rodríguez, Noelia Costa-Rodríguez, Alicia Caro-Vadillo, Elena Carretón, and José Alberto Montoya-Alonso. "Right Ventricle Strain Assessed by 2-Dimensional Speckle Tracking Echocardiography (2D-STE) to Evaluate Pulmonary Hypertension in Dogs with Dirofilaria immitis." Animals 14, no. 1 (December 20, 2023): 26. http://dx.doi.org/10.3390/ani14010026.

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Abstract:
Echocardiographic assessment of the right ventricle is helpful for analysing the pathophysiology of heartworm disease and detecting pulmonary hypertension (PH) in dogs. In veterinary cardiology, the study of myocardial deformation using two-dimensional speckle tracking (2D-STE) echocardiography has become increasingly acknowledged as useful for quantifying right ventricular function. The aim of this study was to evaluate the usefulness of myocardial deformation strain of the right ventricular free wall (FWS), global deformation strain of the right ventricle, including the interventricular septum (GS), and tissue motion annular displacement of the tricuspid valve (TMAD) in a cohort of dogs with heartworm (Dirofilaria immitis) disease and to determine cut-off values for detecting the presence of PH. Out of the 93 dogs tested, 71% were diagnosed with heartworm infection. PH was identified in 41% of the infected dogs following the American College of Veterinary Internal Medicine (ACVIM) guidelines, based on the peak tricuspid regurgitation velocity to calculate the tricuspid regurgitation pressure gradient (TRPG), while other routine measurements were used, including the right pulmonary artery distensibility index (RPADi). The 2D-STE mode measurements were determined using Right Ventricular Automated Function Imaging (RV AFI®) software. The statistical analysis showed significant differences in the studied parameters among dogs with and without PH. Additionally, sensitivity (sen) and specificity (sp) cut-off values were obtained (GS ≥ −21.25%, sen 96%, sp 86.4%; FWS ≥ −21.95%, sen 92.56%, sp 95.5%; TMAD ≤ 0.85 cm, sen 70.4%, sp 83.3%). These results demonstrated that GS, FWS, and TMAD could be used as supplementary and alternative variables to conventional echocardiographic measurements when detecting PH in dogs with heartworm disease.

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