Relevant bibliographies by topics / Early ischaemic heart disease / Dissertations / Theses

Dissertations / Theses on the topic 'Early ischaemic heart disease'

To see the other types of publications on this topic, follow the link: Early ischaemic heart disease.
Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Early ischaemic heart disease.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Hamshere, Stephen. "Investigation of the effect of early intracoronary autologous bone marrow cell infusion in the management and treatment of acute myocardial infarction." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/30705.

Full text
Abstract:
Cardiovascular disease (CVD) is a complex combination of multiple conditions. The majority of deaths within CVD include heart attacks and strokes caused by atherosclerotic disease. The pathophysiological process for atherosclerotic disease occurs within the endothelial lining of the vessels of the body. This prolonged process occurs when cholesterol deposits form irregularity in luminal flow resulting in decreased blood flow and ischaemia. This unstable cholesterol plaque can rupture resulting in clot formation and artery occlusion. Within this thesis I aim to show background to the relevant pathophysiology of ischaemic heart disease (IHD) with the main emphasis on acute myocardial infarction (AMI), the history of its therapy to current therapy. I will discuss the theorised role of stem cell therapy within animal models and previous clinical trials within regenerative medicine and AMI. I will describe and discuss the method and the results of the REGENERATE-AMI trial (Clintrial.gov: NCT00765453), which will include the safety and efficiency of the therapy, and the possible cytokine mechanism by which this therapy may exert it effect. Additionally I will describe the potential for assessing myocardial oedema using 3-slice T2-STIR short axis stack imaging post AMI compared to the conventional 10-slice T2-STIR technique to assess its feasibility and clinical similarity to assess its use as a tool in translational research.
APA, Harvard, Vancouver, ISO, and other styles
2

Wikström, Anna-Karin. "Biochemical and Epidemiological Studies of Early-Onset and Late-Onset Pre-Eclampsia." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8279.

Full text
Abstract:

Biochemical and epidemiological aspects of pre-eclampsia were investigated, with the main focus on possible pathophysiological differences between early-onset and late-onset disease.

In pre-eclamptic women poor correlation was found between albumin-creatinine ratio (ACR) in a random urine sample and total amount of albumin in a 24-hour urine collection. (Paper I)

In a cohort of women giving birth in Sweden in 1973-82 we estimated the adjusted incidence rate ratio (IRR) for ischaemic heart disease (IHD) during the years 1987–2001. The adjusted IRR for development of IHD was 1.6-2.8 in woman exposed to gestational hypertensive disease during her pregnancy compared with unexposed women. The higher risk represents more severe or recurrent hypertensive disease. (Paper II)

Before delivery, in early-onset pre-eclampsia (24-32 weeks) there were pronounced alterations in plasma concentrations of soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF), and also a higher placental 8-iso-PGF2α concentration and an elevated serum ratio of plasminogen-activator inhibitor (PAI)-1 to PAI-2 compared with early controls. In late-onset pre-eclampsia (35-42 weeks) there were only moderate alterations in sFlt1 and PlGF concentrations, and the placental 8-iso-PGF2α concentration and PAI-1/ PAI-2 ratio were similar to those in late controls. (Papers III, V) There was a rapid postpartum decrease in sFlt1 concentration in all groups. One week postpartum the sFlt1 concentration was persistently higher, however, in women with early-onset pre-eclampsia compared with early controls. (Paper IV)

In conclusion: random ACR cannot replace 24-hour urine collections for quantification of albuminuria in pre-eclamptic women; gestational hypertensive disease, especially severe or recurrent, increases the risk for later IHD; early-onset, but not late-onset pre-eclampsia is associated with pronounced alterations of angiogenesis-related markers and only early-onset pre-eclampsia is associated with placental oxidative stress and an increased PAI-1/ PAI-2 ratio, all suggesting a stronger link between early-onset than late-onset pre-eclampsia and a dysfunctional placenta.

APA, Harvard, Vancouver, ISO, and other styles
3

O'Sullivan, Christine Ann. "Electromechanical changes in ischaemic heart disease." Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/8251.

Full text
Abstract:
In coronary artery disease,. resting electrical and mechanical function of the left ventricle may vary according to different presentations. Stress or exercise in these patients results in electrical disturbances, which may havc mechanical consequences. The objectives ofthis thesis were: I) to assess the effect of the presence and location of Q wave myocardial infarction on left ventricular segmental mechanical function and identify patterns ofdisturbances. 2) to study the acute implications of induction of localised myocardial infarction at the proximal ventricular septum on ventricular performance. 3) to determine the effect of pharmacological stress on left and right ventricular behaviour in patients with coronary artery disease. AIl patients were studied by Doppler echocardiography using conventional measurements, as well as detailed assessment of long axis function and 12 lead surface EeG's. The foHowing groups ofpatients were studied: a). 72 patients with old Q wave MI; 35 anterior and 37 inferior. b) 54 patients with old anterior MI; 39 Q wave and 15 non-Q wave MI. c) 20 symptomatic patients with hypertrophic obstructive cardiomyopathy before and after non-surgical septal reduction therapy. d) . 27 patients with coronary artery disease, at rest and during dobutamine stress to assess left ventricular fune:tion. e) 33 patients with triple coronary artery disease at rest and at peak dobutamine stress to assess right ventricular function. The normal septal Q wave was' absent in 94% of anterior and 8% of inferior MI patients. Long axis amplitude and shortening and lengthening velocities were globaIly reduced in anterior and inferior myocardial infarction and the onset of shortening and lengthening were delayed by 30-40ms and 20-30 ms respectively in the two patient groups. Post ejection ~hortening was localised to the septum in the majority of patients with anterior myocardial infarction, but was generalised in patients with inferior infarction. 1) The normal septal Q wave was absent in 10% of control subjects and in 46% of patients with non-Q wave myocardial infarction. Q wave anterior MI was associated with a scarred septum and dilated LV cavity. Long axis amplitude was not different from normal in non-Q wave-infarction, but its onset ofshortening and lengthening was delayed by 20ms. Post ejection shortening occurred more frequently in Q wave infarction (76%) compared with non-Q wave infarction (21 %). These .abnormalities were localised to the left rand septal sites in non-Q wave infarction in contrast to their global distribution in Q wave infarction. . 2) Induction of localised upper septal myocardial infarction with alcohol resulted in broadening of the QRS (by 35ms), RBBB in 80% of patients, development of reduced septal long axis amplitude, and accentuated post ejection shortening at the septal long axis site. 3) In contrast to controls, dobutamine stress results in progressive broadening of QRS duration and prolongation of the QTc interval in patients with coronary artery disease, with corresponding reductions in long axis amplitude of motion and peak lengthening .velocity. 4) In patients with triple vessel coronary disease, dobutamine stress results in right ventricular long axis ischaemic disturbances similar to those seen on the left. Failure ofright ventricular long axis amplitude to increase by 2 mm was 88% specific for detecting right ventricular ischaemic dysfunction, which also correlated with the attenuated cardiac output at peak stress r= 0.56, p
APA, Harvard, Vancouver, ISO, and other styles
4

Horan, P. G. "Unravelling the genetic basis of ischaemic heart disease." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426746.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Byrne, Conor James. "Ischaemic and pharmacological preconditioning of the uraemic heart." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8831.

Full text
Abstract:
The incidence and mortality from cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) far exceeds that seen in the general population. Whilst a number of risk factors and associations have been identified in patients with CKD that may contribute to the increased risk of CVD, our understanding of the underlying pathophysiology remains poor. It has previously been reported that uraemic animals sustain larger myocardial infarcts and that this ‘reduced ischaemia tolerance’ may in part explain the excess mortality from CVD seen in CKD patients. The aim of this work was to establish an in vivo model of uraemic myocardial infarction in order to further explore the pathophysiology of uraemic CVD with particular focus on ameliorating myocardial ischaemia-reperfusion injury using ischaemic and pharmacological preconditioning. An increase in myocardial infarct size was demonstrated in the sub-total nephrectomy model of chronic uraemia, confirming previous reports in the literature. However, infarct size was not found to be increased in adenine diet induced renal failure. In addition, it was demonstrated for the first time, that the techniques of ischaemic preconditioning (IPC) and remote ischaemic preconditioning (RIPC) are both efficacious and not attenuated by chronic uraemia induced by sub-total nephrectomy or adenine diet (IPC only). Investigations were undertaken using an agent (a HIF stabiliser, FG4497) to induce pharmacological preconditioning in both animals with renal insufficiency and those without. These studies demonstrate that stabilisation of hypoxia inducible factor (HIF) may be a promising strategy to induce pharmacological preconditioning. It is hoped that this work may lay the foundations for future investigations to determine why sub-totally nephrectomised rats have larger infarcts whilst those with adenine induced renal failure, with a substantially greater degree of renal dysfunction, do not. Moreover, it is hoped that; by demonstrating that uraemia 3 does not prevent or attenuate the myocardial protection afforded by ischaemic preconditioning, the recruitment of patients with CKD will be encouraged to clinical trials of both ischaemic preconditioning and other therapies to limit myocardial infarction.
APA, Harvard, Vancouver, ISO, and other styles
6

Awad, Wael Ibrahim Issa. "Ischaemic preconditioning in the neonatal rat heart." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391636.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

O'Kane, Peter Danny. "The role of nitric oxide in ischaemic heart disease." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420333.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Mackie, Eileen Elizabeth. "Exercise and haemostasis in health and ischaemic heart disease." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433574.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Claesson, Maria. "Women's hearts : ischaemic heart disease and stress management in women." Doctoral thesis, Umeå : Department of Public Health and Clinical Medicine, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-725.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Teece, Stewart. "The assessment of ischaemic heart disease in the emergency department." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499952.

Full text
APA, Harvard, Vancouver, ISO, and other styles
11

Wright, Robert Anthony. "Hyperinsulinaemia, insulin resistance and endogenous fibrinolysis in ischaemic heart disease." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/21618.

Full text
Abstract:
The work presented in this thesis has explored the hypotheses that disturbances of insulin and of endogenous fibrinolysis are a feature of patients with established ischaemic heart disease and investigated the potential manipulation of these by an inhibitor of the angiotensin converting enzyme. The possibility that the presence of either a previous myocardial infarction or of heart failure might influence the development of hyperinsulinaemia was studied. Only patients with heart failure showed fasting hyperinsulinaemia, whereas the increased insulin response to an oral glucose load in those with heart failure or previous myocardial infarction was similar, and greater than the response in patients with stable angina. Hyperinsulinaemia has been previously associated with impaired peripheral muscle glucose uptake and metabolism and might contribute to the development of muscular fatigue on exertion in patients with previous myocardial infarction or with heart failure. Amongst patients with ischaemic heart disease who had a normal fasting plasma glucose, one fifth had impaired glucose tolerance on formal testing and this group exhibited significantly greater fasting and stimulated hyperinsulinaemia. Including all patients, there was an inverse relationship between left ventricular ejection fraction and fasting plasma insulin concentration. Impaired endogenous fibrinolysis has been associated with an adverse prognosis in patients with ischaemic heart disease. The effect of captopril upon tissue-type plasminogen activator and on plasminogen activator inhibitor type 1 was investigated in patients with recent uncomplicated myocardial infarction. Captopril caused a significant reduction in antigen levels of both type plasminogen activator and on plasminogen activator inhibitor type 1. This may help to explain the reduction in acute coronary syndromes that has been associated with the use of captopril following acute myocardial infarction.
APA, Harvard, Vancouver, ISO, and other styles
12

Spence, M. S. "Family based investigation of the genetic basis of ischaemic heart disease." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268983.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Chia, Stanley. "Endothelial function and endogenous fibrinolysis in inflammation and ischaemic heart disease." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29061.

Full text
Abstract:
In a series of studies, we explored the effects of inflammation on endothelial vasomotion and fibrinolytic capacity using an in vivo forearm model of systemic and local inflammation. Systemic inflammation stimulated by typhoid vaccination had no major effect on vasomotor tone. However, tumour necrosis factor-α induced local vascular inflammation was associated with impaired resistance vessel endothelium-dependent vasodilatation, possibly through the development of acute arterial injury. Both systemic and local inflammation were found to augment the acute release of endothelial tissue plasminogen activator. In addition, intra-arterial tumour necrosis factor-α administration resulted in a unique profile of substantial and sustained local increase in endogenous tissue plasminogen activator. We extended these investigations and assessed the role of endogenous fibrinolysis and endothelial dysfunction in the pathogenesis of prothrombotic conditions such as hyperhomocysteinaemia and coronary stent thrombosis or in-stent restenosis using this forearm model of endothelial function assessment. In patients with recent myocardial infarction, elevation of plasma homocysteine concentration was associated with impaired endothelium-dependent vasodilatation but not endogenous fibrinolysis. This vasomotor dysfunction was not rectified by vitamin supplementation. We also assessed three critical aspects of vascular function in patients who have undergone percutaneous coronary intervention and found no evidence that endothelial vasomotor, fibrinolytic or platelet function play a major role in the pathogenesis of acute stent thrombosis or in-stent restenosis. We conclude that there is complex interaction between inflammation, endothelial endogenous fibrinolysis. Modulating cytokine actions and their interaction with fibrinolysis may be critical in the prevention of thrombotic coronary occlusion and myocardial ischaemia as well as in the future development of anti-thrombotic therapies.
APA, Harvard, Vancouver, ISO, and other styles
14

McCance, Alastai J. "Systemic and cardiac noradrenaline kinetics in ischaemic heart disease in man." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235891.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Siva, Anjana. "The genetic basis of hyperhomocysteinaemia in patients with ischaemic heart disease." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619625.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Zhang, Huajun. "Functional characterisation of cardiac progenitors from patients with ischaemic heart disease." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3b8a7199-c077-436c-bb89-cd354efe4414.

Full text
Abstract:
Ischaemic heart disease (IHD) is the leading cause of death worldwide. Currently, even optimal medical therapies do not attenuate deterioration of the left ventricular (LV) function completely. Stem cell therapies, and recently cardiac stem cell therapies, have emerged as potential novel treatments for IHD. However, clinical evidence from randomised controlled studies has shown mixed results. Thus understanding what patient-related factors may affect the therapeutic performance of the cells may help improving treatment outcomes. The studies described in this thesis aim to understand how cardiac progenitor cells (CPCs) can re-vascularise ischaemic myocardium and promote functional repair of the heart. Resident CPCs were isolated and expanded from the right atrial appendage of 68 patients following the ‘cardiosphere’ method (cardiosphere-derived cells or CDCs). They resemble mesenchymal progenitors as they lack the expression of endothelial and haematopoietic cell surface markers but express mesenchymal progenitor cell markers (e.g. CD105, CD90). Cell function was evaluated by support of angiogenesis, mesenchymal lineage differentiation potential in vitro, and improvement in heart function in vivo. Notably in vitro, CDC from different patients differed in their angiogenic supportive and differentiation potentials. In a rodent model of myocardial infarction (MI), transplantation of CDC reduced infarct size significantly (p<0.05). However, only those CDCs with a robust pro-angiogenic ability in vitro improved vessel density and heart systolic function (p<0.05) in vivo. A multiple regression model, which accounted for 51% of the variability observed, identified New York Heart Association (NYHA) class, smoking, hypertension, type of ischaemic disease and diseased vessel as independent predictors of angiogenesis. In addition, gene expression analyses revealed that differential gene expression of several extracellular matrix components (e.g. CUX1, COL1A2, BMP1 genes and microRNA-29b) could explain the differences observed in CDC’s vascular supportive function. In summary, this is the first description of variability in the pro-angiogenic and differentiation potential of CDCs and its correlation with their therapeutic potential. This study indicates that patient stratification may need to be included in the design of future trials to improve the efficacy of cell-based therapies.
APA, Harvard, Vancouver, ISO, and other styles
17

Swann, Ian D. "Studies of the kallikrein-kinin system in normal and ischaemic rat hearts." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236512.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Bell, Derek. "The acute inflammatory response to myocardial infarction." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/26295.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Workman, A. J. "A study of adenosine triphosphate-sensitive potassium channels in rat hearts." Thesis, De Montfort University, 1996. http://hdl.handle.net/2086/4147.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Moore, Ann Lavinia. "Beta-adrenergic receptor antagonists and exercise radionuclide angiocardiography in patients with proven coronary artery disease." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361290.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

Elfawal, Mohammed Amin. "A pathological study of sudden coronary death in Glasgow." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254218.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Spriggs, David Arthur. "Risk factors for stroke : a case-controlled study." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308766.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Pell, Theresa Jane. "The involvement of ATP-sensitive potassium channels in novel forms of myocardial protection." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314289.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Shaw, Linda Anne. "The influence of platelet derived factors and cholesterol on arrhythmogenesis." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260369.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Williams, John. "Marker proteins in myocardial infarction." Thesis, University of Ulster, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359319.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Kounali, Daphne. "Early growth and coronary heart disease." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436926.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Hayat, Sajad Ahmed. "Myocardial Contrast Echocardiography to Interrogate the Myocardial Microcirculation in Ischaemic Heart Disease." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521584.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Tearse, Rachel Stephanie Houston. "Depressive symptoms in ischaemic heart disease in the Western Isles of Scotland." Thesis, UHI Millennium Institute, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417574.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Smith, Felicity Barbara. "Role of fibrinogen and fibrin D-dimer in peripheral arterial disease." Thesis, University of Glasgow, 1998. http://theses.gla.ac.uk/30947/.

Full text
Abstract:
This thesis is composed of two studies. The principal aim of the first study, the Sites of Atheroma Study, was to determine whether plasma fibrinogen, fibrin D-dimer and other haemostatic factors (von Willebrand Factor and plasminogen activator inhibitor - type I) were related to the angiographic site and severity of atherosclerosis in the arteries of the lower limb. The principal aim of the second study, the Prognostic Study of Intermittent Claudication, was to determine whether plasma fibrinogen, fibrin D-dimer and other haemostatic factors (von Willebrand Factor and tissue plasminogen activator), were related to the future incidence of atherothrombotic events, and deterioration of peripheral arterial disease in subjects with intermittent claudication. The study samples in both studies consisted of men and women with ischaemic symptoms in the lower limb referred to the Peripheral Vascular Clinic, Royal Infirmary of Edinburgh. In the Sites of Atheroma Study, 192 patients referred for angiography were categorised by site and severity of peripheral atherosclerosis using the Bollinger angiographic scoring system. A clinical examination was conducted on each patient including the administration of a questionnaire and taking of a blood sample for the measurement of haemostatic factors. In the Prognostic Study, 607 patients with intermittent claudication who had had a comprehensive examination at baseline, including measurement of haemostatic factors, were followed up over six years to determine the incidence of fatal and non-fatal ischaemic heart disease and stroke and deterioration of peripheral arterial disease. Follow-up data were obtained from hospital records, general practitioners, self-administered questionnaires, the Information and Statistics division of the Common Services Agency and the Scottish National Health Service Central Registry. Results from the Sites of Atheroma Study indicated that 34 (17.7%) patients had predominantly aorto-iliac disease, 85 (44.3%) had femoro-popliteal disease and 73 (38.0%) had dual-site disease. There were no significant differences in the mean levels of the haemostatic factors between patients with disease affecting different sites. An independent relationship was found between nephelometric fibrinogen and between fibrin D-dimer and disease severity only in the femoro-popliteal arteries. On multiple regression, fibrinogen remained independently associated with disease severity in the femoro-popliteal arteries, when life-time smoking or current smoking were taken into account. There was no influence of current smoking on the association between fibrin D-dimer and disease severity but, on inclusion of life-time smoking, the association became non-significant. In the Prognostic Study of Intermittent Claudication, a total of 210 (34.6%) patients died during the six year follow-up period. Of these 90 (42.9%) died from ischaemic heart disease, 29 (13.8%) from stroke and 27 (12.9%) from other vascular causes, including cardiac arrhythmias and ruptured aneurysm. Ninety three (15.3%) patients had a non-fatal myocardial infarction and 79 (13.0%) had a fatal or non-fatal stroke. Forty five (7.4%) patients underwent investigations for peripheral arterial disease and 64 (10.5%) patients progressed to severe chronic leg ischaemia. A total of 203 (33.4%) patients did not have a vascular event or show any deterioration of limb ischaemia. Baseline median levels of plasma fibrinogen, fibrin D-dimer and von Willebrand Factor were significantly higher in patients who died from ischaemic heart disease compared to those who had no vascular events. Tissue plasminogen activator antigen levels were significantly elevated in patients who suffered a stroke. All the relationships between the haemostatic factors and vascular events became weaker and statistically non-significant in analysis adjusting for cardiovascular risk factors and baseline ischaemic heart disease. von Willebrand Factor levels were significantly raised in claudicants who developed severe chronic leg ischaemia (rest pain, ulceration and gangrene). In multivariate analyses adjusting for life-time smoking, fibrinogen became significantly associated with the risk of vascular intervention, and von Willebrand Factor was associated with the risk of severe chronic leg ischaemia. In conclusion, these results indicate that there may be a stronger relationship between chronic smoking and increased fibrin turnover than coagulation in symptomatic peripheral arterial disease. Increased coagulation and fibrinolytic activity may also contribute to thrombosis or progression of atherosclerosis in the coronary and cerebral arteries in claudicants. The effect that fibrinogen, fibrin D-dimer and other haemostatic factors may have on the progression of peripheral arterial disease was mostly independent of cigarette smoking.
APA, Harvard, Vancouver, ISO, and other styles
30

Cullen, James Henry Stuart. "Magnetic resonance imaging in the assessment of myocardial perfusion in ischaemic heart disease." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/29594.

Full text
Abstract:
Five normal volunteers and twenty patients with angiographically proven IHD underwent rest/stress MRI examinations and myocardial scintigraphy for comparison. Five patients had coronary angioplasty and repeat MRI studies three months later. Five patients with Syndrome X were also studied with MRI. MPRI was significantly reduced in patients compared with normals (2.02 0.7 (mean SD), vs 4.21 1.16, p<0.02), with a significant negative correlation of MPRI with percent diameter stenosis of individual coronary lesions (r=-0.81, p< 0.01). MPRI in regions supplied by non-flow limiting lesions (<40% diameter stenosis) was significantly higher than regions supplied by stenoses of 'intermediate' (>40 % to 59%) severity, (2.80 0.77 and 1.93 0.38, p<0.02). Furthermore, MPRI predicted the functional status of the patients reasonably well after revascularisation in this small group. The sensitivity and specificity of quantitative MRI for the detection of global IHD in patients was comparable to thallium-201 scintigraphy (0.89 and 1.0 (sens/spec) vs 0.89 and 1.00) but both were superior to qualitative MRI (0.79 and 0.94). For identifying a significant coronary lesion the sensitivity of quantitative MRI was superior to both qualitative MRI and scintigraphy (0.82, 0.43, 0.75 respectively). The specificity of quantitative MRI was poorer than scintigraphy but similar to qualitative MRI (0.84, 0.89, 0.84). Finally, MPRI in patients with Syndrome X was reduced vs controls (2.17 0.72, p<0.01). Quantitative MRI perfusion studies can provide functional information to detect IHD in patients and assess adequacy of revascularisation. Furthermore, it may be able to provide insight into the mechanism of ischaemia in patients with Syndrome X.
APA, Harvard, Vancouver, ISO, and other styles
31

Sridhara, Bangalore Sitaramiah. "Clinical evaluation of '9'9'mTc tetrofosmin in the detection of ischaemic heart disease." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259561.

Full text
APA, Harvard, Vancouver, ISO, and other styles
32

Woodhouse, Peter Robert. "Seasonal variation of cardiovascular disease risk factors in older adults." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295672.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Snaith, Christine D. "The use of amino acids to improve the production of high energy phosphates in the ischaemic myocardium." Thesis, Keele University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277152.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Schwarz, Konstantin. "The effects of inorganic nitrate and nitrite on the heart : metabolic efficiency and therapeutic potential for ischaemic heart disease." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229509.

Full text
APA, Harvard, Vancouver, ISO, and other styles
35

Arnold, J. R. "Evolving non-invasive techniques for the assessment of myocardial perfusion in ischaemic heart disease." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543046.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Lock, Rachel. "The quantitative assessment of ischaemic heart disease : a study of the Leeds Exercise Test." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/34138.

Full text
Abstract:
Elamin, Mary, Smith Linden, 1980 suggested that the rate of development of ST segment depression with increasing heart rate during a standardised exercise test could predict the number of coronary arteries (0, 1, 2 or 3) seen to be ocluded on the coronary arteriogram. Several attempts to repeat this "Leeds exercise test" had been unsuccessful possibly through inadequate adherence to the Leeds protocol. The work described in this thesis is a further attempt to replicate the Leeds test as precisely as possible after a period of instruction at Leeds. A Leeds test and coronary arteriography were performed on 49 patients at Groby Road Hospital, Leicester. Results of identical exercise ECGs analysed at Leeds and Leicester were compared to ensure the same methods were used and highlight potential causes of disparate results through differences in method. Results of arteriograms assessed at both centres and on two occasions at Leicester were compared to test the reproducibility of the arteriogram and so its value as an index of coronary disease. A computer assisted method of measuring the exercise ECG was developed. The results of coronary arteriography and exercise testing were correlated to assess the Leeds test for the prediction of coronary disease severity. The following main reasons why the Leeds' results have not been repeated at any other centre are proposed: 1. There has been sufficient deviation from the described methods of performing the exercise test and assessing the arteriogram. 2. Patient variables (drug regime and cardiac complications other than coronary disease) may affect the ST/HR slope. 3. There is a large variance associated with the arteriogram result and the estimate of the ST/HR slope. 4. It is questionable that an exact correlation can occur between the results of exercise testing and coronary arteriography. Also, a 3 vessel disease terminology to quantify coronary disease is inadequate. It is recognised that the maximal ST/HR slope is an improved index of myocardial ischaemia which has probably had limited acceptance through being assessed against arteriogram results in terms of 0, 1, 2, and 3 vessel disease. Finally, having highlighted the limitations of exercise testing and coronary arteriography, the potential of nuclear magnetic resonance in the quantitative and qualitative assessment of ischaemic heart disease in the future is addressed.
APA, Harvard, Vancouver, ISO, and other styles
37

Ridge, Charlotte. "Elemental concentrations in blood from diabetic and non-diabetic coronary artery bypass patients using neutron activation analysis and proton induced X-ray emission analyses." Thesis, University of Surrey, 2001. http://epubs.surrey.ac.uk/843100/.

Full text
Abstract:
Diabetes is one of the fastest growing diseases today, affecting over a million people in the UK. Numerous medical complications, such as heart disease, are regularly associated with diabetes. Despite advances in methods of diagnosis and treatment there is still a need for greater understanding of these diseases. This will include research directed towards the influence of specific treatments and reasons for the high incidence of diabetes and heart disease in 'at risk' populations. Changes in elemental status are associated as the cause or effect of various diseased states. Elemental imbalance in diabetics can result in impaired glucose tolerance and insulin resistance and in sufferers of heart disease elemental changes impair heart rate and elasticity of blood vessels. In the UK 10,000 patients with Ischaemic Heart Disease undergo coronary artery bypass grafting (CABG) surgery each year. Elemental analysis has been carried out on blood samples collected from a group of patients admitted to hospital for bypass surgery. Proton Induced X-ray Emission (PIXE) and Instrumental Neutron Activation Analysis (INAA) have been applied as complementary analytical tools for determining elemental concentrations. Differences have been examined between CABG patients with and without diabetes. Both experimental methods have been used to investigate elemental levels in whole blood, erythrocytes and plasma. Elemental concentration varied according to the blood constituent and reflected short and long-term influences on elemental homeostasis. Plasma was found to concentrate Na, Mg and Ca the highest using both experimental techniques. All blood samples were collected and prepared at St. George's Hospital, Tooting in the UK. An additional study was conducted to investigate the influence of the bypass operation on the patient's elemental status. Whole blood was obtained at pre (1h before operation), post (1-2 hours after operation) and recovery (24 hours after completion of the operation) stages of bypass surgery. Differences between the three phases were observed, individual variations have been plotted so rates of change can be seen and evaluated with the particular medical history. Concentrations of Na, Mg, Al, P, S, Cl, K, Ca and Fe in whole blood were determined. The two measurement techniques found different concentrations however results showed a general trend that post operative concentrations were elevated compared to pre operative values. Analysis of blood drawn during the recovery phase, 24 hours after the surgery, found that concentration were typically approaching pre operative levels. Both PIXE and INAA found concentrations of Na, Mg and Al peaked post operation and then decreased in the recovery phase, towards values measured pre surgery. Various factors may be responsible for the elemental changes occurring during surgery including, hormone production, routine administration of intra-operative fluids and contact of blood with non- endothelial surfaces. Hierarchical cluster analysis has been used to confirm differences between elemental levels in pre, post and recovery stages of bypass surgery. The dendograms produced indicate significant distinction between the three stages. The explosive impact of diabetes in the UK resident Asian population is discussed and the influence of diabetogenic agents introduced. Examination of research literature revealed that betel nut has been implicated as a causative agent in several medical conditions. Samples of Betel nut and six associated chewing materials widely used in Asian communities has been collected and prepared for analysis. Instrumental neutron activation analysis has been used to determine the concentration of Na, Mg, Al, Cl, Ca, V, Mn, Cu and Br in the samples by means of short-lived radionuclides.
APA, Harvard, Vancouver, ISO, and other styles
38

Groves, Peter H. "The influence of exogenous nitric oxide on the pathophysiology of angioplasty injury." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308763.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Robertson, D. N. "A study of blood platelets in experimental myocardial ischaemia." Thesis, Robert Gordon University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377585.

Full text
APA, Harvard, Vancouver, ISO, and other styles
40

Watts, Eric J. "Coagulation changes in long distance runners and their relevance to the prevention of ischaemic heart disease." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328774.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Yasin, Mohammed. "Non-regenerative benefits of adult bone marrow derived stem cells for myocardial protection." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8701.

Full text
Abstract:
Ischaemic heart disease is the most common cause of mortality in the western hemisphere and it is rapidly becoming the leading cause of death globally. Moreover, therapeutic interventions by cardiologists and cardiac surgeons frequently subject the heart to acute I/R injury, which in itself can cause mortality. Recent investigations of adult stem cells have primarily focused on their regenerative potential for chronic ischaemic heart disease. In this thesis, I have investigated the hypothesis that adult bone marrow derived stem cells are cardioprotective in acute regional myocardial I/R injury. In a rat model of left anterior descending coronary artery (LAD) reversible occlusion and reperfusion, I demonstrate that an intravenous bolus of adult bone marrow derived (1) bone marrow mononuclear (BMNNC) and (2) mesenchymal stem cells (MSC) upon reperfusion can attenuate infarct size. This effect is comparable to ischaemic preconditioning (IPC), which is the gold standard for cardioprotection. Next, I demonstrated the mechanisms for adult stem cell cardioprotection are principally anti-apoptotic and depend upon stem cell secreted factors to (1) activate phosphatidylinositide 3-kinase (PI3)/Akt cell survival kinase-signaling pathway (2) inhibit glycogen synthase kinase-3β (3) inhibit p38MAPK (4) inhibit nuclear translocation of p65NF-κB. 7 Proteomic analysis of myocardium subjected to I/R and treated with either BMMNC or BMMNC derived supernatant (BMS) upon reperfusion demonstrated higher expression of a whole host of pro-survival proteins. These were notably (1) 14-3-3-ε protein (2) anti-oxidant peroxiredoxin-6 (3) heat shock protein (HSP) αB-crystallin, HSP72, HSP tumour necrosis factor receptor-1 associated protein, and HSP ischaemia responsive protein-94 (4) glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (5) mitochondrial aconitase and mitochondrial voltage-dependent anionselective channel protein-1. Thereafter, I investigated the mobilization of endogenous bone marrow stem cells and trafficking to the ischaemic myocardium by stromal cell derived factor-1 (SDF-1) /chemokine, receptor type 4 (CXCR4) signaling. I demonstrate high up-regulated expression of CXCR4 and CD26 in BMMNC following IPC, which might have a role in IPC-mediated cardioprotection. Finally, and in concordance with this finding I demonstrate that both IPC and an exogenous MSC bolus upon reperfusion can synergize to abolish acute myocardial I/R injury.
APA, Harvard, Vancouver, ISO, and other styles
42

Haider, Agha Waqar. "Continuous electrocardiographic recording in the assessment of ischaemic heart disease : technical problems and clinical role." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243945.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Casadei, Barbara. "Some aspects of the parasympathetic control of the cardiovascular system in man." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297082.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

McGlinchey, P. G. "An investigation of the genetic basis of ischaemic heart disease using family based tests of association." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273055.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Atkinson, C. "The effects of isoflavones on some risk factors for breast cancer, osteoporosis, and ischaemic heart disease." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596214.

Full text
Abstract:
To investigate whether phytoestrogens had an antioestrogenic effect, a large double blind, randomised, placebo controlled trial was conducted for approximately one year. Mammographic breast density, hormone levels, menopausal symptoms, cardiovascular risk factors, bone density, and body composition were assessed. When compared with the effects of placebo, 40mg daily dose of isoflavones did not significantly alter mammographic breast density when assessed by several different methods. Mean change in estimated percent density determined from the mammogram comparison data was - 1.35% (SD 5.16) in the isoflavone group, and -1.79% (SD 7.41) in the placebo group. There was also no significant effect on levels of oestradiol, FSH, or LH. Menopausal symptoms, and hot flushes specifically, were not significantly altered by clover isoflavones. Cardiovascular risk factors (blood pressure, blood lipids, and blood clotting factors) were also not significantly altered. However, the isoflavones did affect bone density. Spine bone mineral density (BMD) decreased to a significantly lower extent in the isoflavone group compared with that seen in the placebo group (p<0.01). The effect on BMD was mainly seen in the pre- and peri-menopausal women, and isoflavones also had a significant effect on BMC in this group. Levels of the bone resorption marker, deoxypyridinoline (Dpd) increased in both the isoflavone and placebo pre- and peri-menopausal groups. However, the increase was significantly lower in the isoflavone group compared with placebo (p=0.03), supporting the finding of a beneficial effect of isoflavones on bone as judged by BMD and BMC. Similar trends (not significant) regarding BMC and BMD were seen in the hip in pre-and peri-menopausal women, and there was a significant increase in body fat with the isoflavone supplement in this group (p<0.01).
APA, Harvard, Vancouver, ISO, and other styles
46

Broadbent, David Andrew. "Quantitative dynamic contrast enhanced magnetic resonance imaging for evaluation of the myocardium in ischaemic heart disease." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/16667/.

Full text
Abstract:
Background: Use of contrast enhanced cardiac magnetic resonance imaging (MRI) for identification of focal pathology (perfusion deficit and scar) is widespread. Quantitative analysis of dynamic contrast enhanced (DCE) MRI data may allow objective assessment of focal and diffuse disease. However it is a complex process and not widely adopted outside the research domain. For accurate quantification temporal variation in relative contrast agent concentration in the myocardium and feeding blood supply must be measured. While MRI signal intensity can be used as a probe of contrast agent concentration its response is non-linear. Aims: In this thesis non-linearity correction methods for quantitative myocardial DCE-MRI are compared, the feasibility of a novel bookend T1 based correction is tested and the method is used in clinical studies to assess myocardial characteristics in health and ischaemic disease. Methods: Signal non-linearity correction methods were compared using simulation, phantom experiments and a volunteer study. Methods compared were independent sampling strategies (dual-bolus and dual-sequence), previously proposed model based correction (native T1 or proton density weighted image based) and bookend T1 based correction which is proposed as a method to account for imperfect magnetisation preparation. The feasibility of the bookend T1 method was tested and characteristics of heathy and diseased myocardium were assessed in clinical studies of ischaemia and infarction. Conclusions: Native T1 based correction has been found to be highly sensitive to imperfect magnetisation preparation, and is thus recommended against. Model based correction using proton density weighted images or bookend T1 data have been found to be more accurate and precise than dual-sampling methods. The clinical studies have demonstrated the feasibility of the bookend T1 based method and have yielded insights into myocardial characteristics in a range of conditions.
APA, Harvard, Vancouver, ISO, and other styles
47

Bull, Adrian Richard. "Early determinants of blood pressure and related disease." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238962.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

Markey, Peter. "The prevalence of ischaemic and rheumatic heart disease and risk factors in Aboriginal and non-Aboriginal footballers /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09MPM/09mpmm345.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Stonier, William Carl. "Effects of counselling on heart disease : an investigation into the effect of a counselling and guided imagery programme on the outcome of people with ischaemic heart disease." Thesis, University of Hull, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430987.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Derry, Christopher William. "The relationship between the hardness of potable water and cardiovascular and ischaemic heart disease mortality in South African urban areas." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/25808.

Full text
Abstract:
Studies carried out in a number of countries have revealed statistically significant negative correlations between death rates from cardiovascular disease (CVD) or ischaemic heart disease (IHD), and the hardness of local water supplies, a phenomenon which is known as the "water story". These findings have not, however, been universal and it was decided that a study carried out in South Africa with its high CVD and IHD death rates, might yield meaningful results to contradict or support existing findings. In 1983 a pilot study was thus initiated using a spatial model and a more detailed study began in 1984. This study ultimately involved the correlation of standardized mortality ratios (SMRs) for CVD and IHD with total water hardness and with a number of contributory and associated water quality factors. The study supported the hypothesised "water story", showing the existence of negative correlations between standardized mortality ratios (SMRs) for both CVD and IHD, and the hardness of potable water, whether measured as total hardness or as its two major contributory cations, calcium and magnesium. The level of statistical significance at which this correlation occurred, however, varied with differences in methodological approach. A "population-unweighted" methodology, which was applied to enable comparison with a number of previously published studies, pointed to potassium (a known hypertension normalisor) in permanently hard water as being an important factor. Problems inherent to each methodological approach have been discussed as has the need for improved data. In this regard, the need for a National water quality data bank has been emphasised.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Early ischaemic heart disease' for other source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography