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1

E, Lyons Kelly, ed. Management of early Parkinson's disease. [Oxford]: Oxford University Press, 2009.

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2

P, Dostert, Erbamont Inc, and Fondazione Carlo Erba, eds. Early markers in Parkinson's and Alzheimer's diseases. Wien: Springer-Verlag, 1990.

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3

Carlos, Kaski Juan, and Holt David W, eds. Myocardial damage: Early detection by novel biochemical markers. Dordrecht: Kluwer Academic, 1998.

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4

1933-, Fahn Stanley, ed. Parlodel® (bromocriptine mesylate) in the early management of Parkinson's disease: Excerpts from Recent developments in Parkinson's disease, volume 2. Florham Park, N.J: Macmillan Healthcare Information, 1987.

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5

McCarthy, Joseph C. Early hip disorders: Advances in detection and minimally invasive treatment. New York: Springer, 2011.

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6

name, No. Early hip disorders: Advances in detection and minimally invasive treatment. New York, NY: Springer, 2003.

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7

editor, Mordini E. (Emilio), and Green Manfred editor, eds. Internet-based intelligence in public health emergencies: Early detection and response in disease outbreak crises. Amsterdam, Netherlands: IOS Press, 2011.

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8

Long, Katrina M. Pre-active PD: A Therapist Delivered Physical Activity Behavior Change Program for People With Early Stage Parkinson's Disease. [New York, N.Y.?]: [publisher not identified], 2020.

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9

Fitzgerald, Rebecca C. Pre-invasive disease: Pathogenesis and clinical management. New York: Springer, 2011.

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10

Christophe, Trivalle, ed. Gérontologie préventive: Éléments de prévention du vieillissement pathologique. Paris: Masson, 2002.

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11

Patlak, Margie. Mammography and beyond: Developing technologies for the early detection of breast cancer : a non-technical summary. Edited by National Cancer Policy Board (U.S.). Committee on the Early Detection of Breast Cancer and National Research Council (U.S.). Commission on Life Sciences. Washington, D.C: National Academy Press, 2001.

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12

Wells, F. O. Preventive medicine: Working for patients : a review of the therapeutic areas where screening programmes and the early detection and treatment of disease will benefit patients and the NHS. London: Association of the British Pharmaceutical Industry, 1989.

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13

Lyons, Kelly E., and Rajesh Pahwa. Early Recognition and Diagnosis in Parkinson's Disease. Oxford University Press, 2010.

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14

Hoyle, Nicholas R., Thompson Michael, Richard Morgan, Subrayal M. Reddy, and Damien Arrigan. Early Detection of Biomarkers for Disease. Royal Society of Chemistry, The, 2017.

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15

Early diagnosis and preventive therapy in Parkinson's disease. Wien: Springer-Verlag, 1989.

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16

Riederer, Peter, and Horst Przuntek. Early Diagnosis and Preventive Therapy in Parkinson's Disease. Springer London, Limited, 2012.

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17

Riederer, Peter, and Horst Przuntek. Early Diagnosis and Preventive Therapy in Parkinson's Disease. Lar, 1989.

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18

Early Diagnosis and Preventive Therapy in Parkinson's Disease. Springer, 2012.

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19

Blake-Krebs, M. A. Barbara, M.L.S., Linda Herman, and R.N., L.C.S.W., Susan Reese. When Parkinson's Strikes Early: Voices, Choices, Resources, and Treatment. Hunter House Publishers, 2001.

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20

Early Detection of Alzheimer's Disease: A Neuropsychological Approach. Academic & Scientific Publishers, 2008.

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21

Gao, Youhe. Urine: Promising Biomarker Source for Early Disease Detection. Springer, 2019.

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22

Albert, Marilyn S., and Guy M. Mckhann. Neuroethical Issues In Early Detection Of Alzheimer’S Disease. Oxford University Press, 2011. http://dx.doi.org/10.1093/oxfordhb/9780199570706.013.0135.

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23

Gao, Youhe. Urine: Promising Biomarker Source for Early Disease Detection. Springer Singapore Pte. Limited, 2020.

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24

(Editor), J. C. Kaski, and David W. Holt (Editor), eds. Myocardial Damage: Early Detection by Novel Biochemical Markers. Springer, 1998.

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25

Holt, David W., and Juan Carlos Kaski. Myocardial Damage: Early Detection by Novel Biochemical Markers. Springer London, Limited, 2013.

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26

Myocardial Damage: Early Detection by Novel Biochemical Markers. Springer Netherlands, 2010.

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27

Chan, Dennis. Early Detection in Alzheimer's Disease: Biological and Technological Advances. Academic Press, 2021.

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28

Chan, Dennis. Early Detection in Alzheimer's Disease: Biological and Technological Advances. Elsevier Science & Technology Books, 2021.

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29

Edoh, Thierry. Pre-Screening Systems for Early Disease Prediction, Detection, and Prevention. IGI Global, 2018.

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30

C, Morris John, and Jeffrey M. Burns. Mild Cognitive Impairment and Early Alzheimer's Disease: Detection and Diagnosis. Wiley & Sons, Incorporated, John, 2008.

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31

Diffusion Tensor Imaging and Fractional Anisotropy: Imaging Biomarkers in Early Parkinson's Disease. Springer, 2023.

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32

Kotian, Rahul P., and Prakashini Koteshwar. Diffusion Tensor Imaging and Fractional Anisotropy: Imaging Biomarkers in Early Parkinson's Disease. Springer, 2022.

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33

Treasures in the Darkness: Extending the Early Stage of Lewy Body Dementia, Alzheimer's, and Parkinson's Disease. CreateSpace Independent Publishing Platform, 2012.

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34

Roze, Emmanuel, and Nenad Blau. Biogenic Monoamine Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0031.

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Biogenic monoamine disorders are a group of inherited diseases characterized by a defect in the synthesis, transport, or degradation of catecholamines and serotonin. The phenotype mostly reflects the pattern and severity of the monoamine deficiency. Movement disorders due to cerebral dopamine deficiency are almost always prominent, mostly in the form of dystonia and/or parkinsonism. These disorders are potentially devastating yet treatable. Early diagnosis and treatment are crucial to prevent ongoing brain dysfunction. Detection of hyperphenylalaninemia in a neonate could be a good clue to the diagnosis. Final diagnosis is often based on a detailed biochemical investigation of the cerebrospinal fluid and can be confirmed by molecular analysis. Treatment is aimed at restoring neurotransmitter homeostasis using monoamine precursors, monoamine agonists, and inhibitors of monoamine degradation. It also comprises the control of hyperphenylalaninemia and the prevention of cerebral folate deficiency, when applicable.
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35

Lemiere, Jurgen. Huntington's Disease: Early Detection & Progression of Cognitive Changes in Patients & Asymptomatic Mutation Carriers (Acta Biomedica Lovaniensia). Leuven Univ Pr, 2004.

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36

Fitzgerald, Rebecca C. Pre-Invasive Disease: Pathogenesis and Clinical Management. Springer, 2014.

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37

Martinez, Jaun Jair. An international telemedicine model design: Using e-health to improve chronic disease early detection and initial management in rural areas. 2005.

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38

Kelly, Laura, and William P. Stanford. Implementation of Personalized Precision Medicine: Expanding the Clinical Vision Towards Prevention, Early Detection and Precision Treatment of Disease to Drive Extended Healthspan. Elsevier Science & Technology, 2023.

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39

Kelly, Laura, and William P. Stanford. Implementation of Personalized Precision Medicine: Expanding the Clinical Vision Towards Prevention, Early Detection and Precision Treatment of Disease to Drive Extended Healthspan. Elsevier Science & Technology Books, 2023.

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40

Chneiweiss, Hervé. Anticipating a therapeutically elusive neurodegenerative condition: Ethical considerations for the preclinical detection of Alzheimer’s disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198786832.003.0016.

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Among neurodegenerative disorders, Alzheimer’s disease has held a special position during the last 40 years. It represents a huge burden of disease with more than 40 million people affected worldwide. The economic effect it has on society is enormous, and the specific challenges of dementia are tremendous. Now that science has demonstrated that the disease starts two or three decades before any symptoms occur, possibilities exist for diagnosis or testing increasingly early through the capabilities of predictive medicine. The related ethical debate is on the multiple meanings and the impact of preclinical diagnosis of Alzheimer’s disease before the onset of symptoms. To guide this discussion, this chapter draws upon lessons from other fields of medicine and the identification of high-risk individuals bearing pathogenic genetic mutations that predispose them to the disease. It concludes with thoughts on value and choice in the complex, fine balance between anticipating, knowing, and doing.
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41

Keshav, Satish, and Alexandra Kent. Screening for gastrointestinal disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0354.

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This chapter discusses screening for gastrointestinal disease, including Barrett’s oesophagus (BO), colorectal cancer, and hepatocellular cancer (HCC). In patients with BO, approximately 5% will develop dysplasia, and 10%–50% of the low-grade dysplasias will progress to high-grade dysplasia or adenocarcinoma within 2–5 years. Thus, screening for BO has been developed to reduce the development of adenocarcinoma via the early detection of high-grade dysplasia or cancer in situ. The main aim of colorectal cancer screening is the early detection of polyps and cancers, at a time when treatment is likely to be more effective. Similarly, early detection of HCC is advantageous, as the prognosis in advanced disease is very poor. This chapter describes the current processes of screening for these diseases, and the impact of this screening, as well as screening for gastrointestinal cancer in specific groups.
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42

Trivalle, Christophe. Gérontologie préventive : Eléments de prévention du vieillissement pathologique. Editions Masson, 2002.

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43

Grassberger, Martin, Ronald A. Sherman, and Olga S. Gileva. Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms. Springer, 2013.

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44

Kim, Christopher, Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, and Kosta Mumcuoglu. Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease Using Living Organisms. Springer London, Limited, 2013.

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45

Kim, Christopher, Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, and Kosta Mumcuoglu. Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms. Springer, 2013.

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46

Kim, Christopher, Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, and Kosta Mumcuoglu. Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms. Springer, 2015.

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47

Tribouilloy, Christophe, Patrizio Lancellotti, Ferande Peters, José Juan Gómez de Diego, and Luc A. Pierard. Heart valve disease (aortic valve disease): aortic regurgitation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0033.

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Echocardiography is the cornerstone examination for the assessment of aortic regurgitation (AR): it provides reliable evaluation of the aortic valve and allows diagnosis and identification of the mechanism of regurgitation. The specific aetiology of the disease can be identified in the majority of cases. A combination of quantitative and quantitative Doppler and two-dimensional (2D) echocardiographic parameters allows the evaluation of the severity of AR and determination of the haemodynamic and left ventricular function repercussions. Echocardiography allows the detection of associated lesions of the aortic root or other valves. In symptomatic patients, echocardiography is essential to confirm the severity of AR. In asymptomatic patients with moderate or severe AR, echocardiography is essential for regular follow-up, by providing precise and reproducible measurements of LV dimensions and function, and for identifying patients who should be considered for elective surgical intervention. In most cases, transthoracic echocardiography (TTE) provides all of the necessary information and transoesophageal echocardiography in usually not required. Real-time three-dimensional (3D) TTE can be complementary to 2D echocardiography for the assessment of the mechanism and quantification of AR by increasing the level of confidence, especially when 2D echocardiographic data are inconclusive or discordant with clinical findings. Tissue Doppler imaging and especially the speckle tracking method are promising approaches to detect early LV dysfunction in patients with asymptomatic severe AR. Echocardiography is therefore the key examination for the assessment of AR and at the centre of the strategic discussion concerning the indications and timing of surgery.
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48

Zika Virus Disease. Exon Publications, 2024. http://dx.doi.org/10.36255/zika-virus-disease.

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Zika Virus Disease is a mosquito-borne illness that can cause mild symptoms such as fever, rash, and joint pain but is particularly concerning for its potential to cause severe birth defects and neurological complications. This article provides a detailed understanding of Zika Virus Disease, serving as a valuable resource for the public. The article begins with an introduction to the virus, explaining its origins and primary modes of transmission. It covers the causes of infection, including how the virus is transmitted by mosquitoes and other methods. The article discusses the different strains of the virus, risk factors, and how common the disease is. Readers will learn about the signs and symptoms, how the disease spreads, and the methods used for diagnosis. The pathophysiology of the virus is explained, along with the treatment options available, which mainly focus on supportive care. Preventive measures are outlined to help reduce the risk of infection. The article concludes with a summary emphasizing the importance of early detection, appropriate treatment, and preventive measures. All information is presented in simple terms to ensure it is understandable for all readers.
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49

Chakera, Aron, William G. Herrington, and Christopher A. O’Callaghan. Prevention of kidney disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0345.

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A number of factors are known to predispose to renal disease, such as diabetes mellitus, hypertension, and exposure to certain drugs or substances (e.g. mercury and other heavy metals). In people who are at risk for these reasons, renal function should be regularly monitored as part of routine care. Kidney diseases are identified by elevations in the serum creatinine; the presence in the urine of blood, protein, or elevated levels of certain electrolytes; or evidence of anatomical abnormalities. Due to the large functional reserve of the kidneys, symptoms of impaired renal function usually occur late in the course of disease, highlighting the importance of early detection and, where available, the use of ameliorating therapies.
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50

Morrison, Karen. Prevention of cerebrovascular disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0348.

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Stroke is the main cause of neurological morbidity in adults and the third most common cause of death worldwide after ischaemic heart disease and cancer (all forms combined). It is more common in older people, with three-quarters of strokes occurring in people over 65 years of age, and estimates are that overall stroke morbidity will double by the early 2020s. The worldwide figure of increasing incidence of stroke detection masks the fact that mortality from stroke has actually been falling in developed countries since the latter half of the twentieth century while the mortality has continued to rise in China, Asia, and eastern Europe. This chapter discusses prevention of cerebrovascular disease, and includes strategies to reduce the risk of thromboembolic stroke and cerebral haemorrhage.
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