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Santos, Paulo Roberto, Diego Levi Silveira Monteiro, Paulo Henrique Alexandre de Paula, Vicente Lopes Monte Neto, Maria Leilah Ponte Monte Coelho, Cecília Costa Arcanjo, Fernando Lopes Ponte Neto, et al. "Dyspepsia is Associated with Low Protein and Caloric Intake among End-Stage Renal Disease Patients." International Journal for Vitamin and Nutrition Research 85, no. 3-4 (December 2015): 112–18. http://dx.doi.org/10.1024/0300-9831/a000230.
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Abstract. Background: Dyspepsia is highly prevalent and easily assessed in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) and is not a traditional predictor of malnutrition. We sought to establish an association between dyspeptic symptoms and nutritional status in ESRD patients undergoing maintenance HD. Methods: We studied 106 ESRD patients on HD. Dyspepsia was assessed through the Porto Alegre Dyspeptic Symptoms Questionnaire (PADYQ). Scores equal to or greater than 6 classified patients as dyspeptic. Nutritional status was evaluated using serum chemistry, total body mass, muscle mass, and dietary intake. Nutritional status was compared between dyspeptic and non-dyspeptic patients. The association of PADYQ scores and the presence of dyspepsia with nutritional variables were tested. Multivariate analysis was performed to test dyspepsia as an independent predictor for dietary intake. Results: There were 41 (38.7 %) dyspeptics. Protein intake (g/kg/day) and calorie intake (kcal/kg/day) were lower among dyspeptics compared to non-dyspeptics, 1.0 ± 0.5 vs 1.3 ± 0.5 (p = 0.01) and 23.0 ± 9.2 vs 27.4 ± 10.0 (p = 0.02), respectively. More dyspeptics than non-dyspeptics presenting protein-energy wasting based on protein and calorie intake, 41.4 vs 15.3 % (p = 0.01) and 68.2 vs 38.4 % (p = 0.02), respectively. PAQYQ score was negatively correlated with protein intake (r = - 0.20; p = 0.03) and calorie intake (r = - 0.19; p = 0.04). Dyspepsia was able to predict protein (b = - 0.26; p = 0.01) and calorie (b = - 4.42; p = 0.02) intake. Conclusions: Dyspepsia is associated with low protein and calorie intake. Screening of dyspeptic symptoms can be routinely performed aiming to improve HD patients’ nutritional status.
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Bakulina, N. V., S. V. Tikhonov, and N. B. Lishchuk. "Chronic gastritis and functional dyspepsia. Unity and struggle of two opposites." Meditsinskiy sovet = Medical Council, no. 15 (October 19, 2021): 164–74. http://dx.doi.org/10.21518/2079-701x-2021-15-164-174.
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The review article describes the epidemiology, clinical picture, pathogenesis, approaches to the diagnosis and treatment of chronic gastritis and functional dyspepsia. Chronic gastritis is an unreasonably common diagnosis in our clinical practice, which is diagnosed in patients with disturbing dyspeptic complaints. According to the agreement documents, chronic gastritis is primarily a morphological concept. Chronic gastritis has no pathognomonic clinical signs and should be diagnosed during the histological examination of the gastric mucosa. Functional dyspepsia is a diagnosis that reflects the presence of a certain symptom complex (pain or burning sensation in the epigastrium, a feeling of fullness or early satiety) in the absence of diseases that could explain the symptoms. Secondary dyspepsia is diagnosed in patients with organic diseases of the upper gastrointestinal tract, metabolic or systemic diseases that cause dyspeptic syndrome. In the process of examining a patient with disturbing dyspeptic complaints, it is advisable for the doctor to use the diagnosis “unspecified dyspepsia” – a preliminary diagnosis before laboratory and instrumental examination aimed at identifying the cause of the dyspeptic syndrome. Dyspepsia associated with H. pylori is diagnosed in patients with H. pylori infection. The diagnosis is revised over time and is competent if complaints have been relieved within 6 months after effective H. pylori eradication.The main drugs for the treatment of patients with dyspeptic complaints are proton pump inhibitors and prokinetics. Omeprazole with domperidone sustained release (SR) in a fixed dose combination is characterized by optimal efficacy and a good safety profile in patients with both functional and secondary dyspepsia and ensures a high level of treatment adherence.
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Chan, Pak-Hei, Jo-Jo Hai, Duo Huang, Mei-Han Ho, Esther W. Chan, Bernard Man-Yung Cheung, Annie On-On Chan, et al. "Burden of upper gastrointestinal symptoms in patients prescribed dabigatran for stroke prevention." SAGE Open Medicine 4 (January 1, 2016): 205031211666241. http://dx.doi.org/10.1177/2050312116662414.
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Background: Dabigatran, a non-vitamin K antagonist oral anticoagulant, has been shown to prevent stroke in patients with non-valvular atrial fibrillation. Nonetheless, studies show that 10%–30% of those prescribed dabigatran experience dyspepsia that may eventually lead to discontinuation of therapy and loss of clinical benefit. Aim: To evaluate the gastrointestinal tolerability of dabigatran utilizing a validated questionnaire, as well as determining subsequent non-compliance and drug discontinuation. Method: This is an observational study. All patients were assessed by a validated questionnaire, Hong Kong dyspepsia index, prior to drug prescription and again 4 weeks later. Results: In this study, 115 patients with non-valvular atrial fibrillation (mean age: 74.6 ± 11.4 years; mean CHA2DS2-VASc score was 3.39 ± 1.59) were prescribed dabigatran. At baseline, the mean Hong Kong dyspepsia index was 12.9 ± 1.6 and nine patients had significant dyspepsia (Hong Kong dyspepsia index ⩾ 16). After 4 weeks, the mean Hong Kong dyspepsia index was similar at 12.6 ± 1.9 ( p = 0.23). There was no change in Hong Kong dyspepsia index after initiation of dabigatran in 59 (51.3%) patients, and improvement in 37 (32.2%). Only 19 (16.5%) patients had worsening of Hong Kong dyspepsia index, and among these 19 patients, only 1 patient (0.9%) discontinued dabigatran due to significant dyspepsia. Conclusion: Worsening of dyspepsia with dabigatran 110 mg twice daily was uncommon with correct drug administration and clear instructions provided. Systematic assessment of dyspeptic symptoms using a validated questionnaire (i.e. Hong Kong dyspepsia index) before and after treatment initiation allows a more objective comparison of dyspeptic symptoms.
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Febriani, Tien Budi, Titis Widowati, and Mohammad Juffrie. "Reducing dyspeptic symptoms in children: proton pump inhibitor vs. H2 receptor antagonist." Paediatrica Indonesiana 54, no. 4 (August 31, 2014): 198. http://dx.doi.org/10.14238/pi54.4.2014.198-201.
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Background Dyspepsia is known as a leading cause of uppergastrointestinal tract morbidity. If left untreated, dyspepsia maybecome chronic. Dyspeptic symptoms manifest as epigastricpain, heartburn, nausea, hematemesis, or melena. Experimentalstudies have shown that omeprazole is more effective at reducingheartburn than ranitidine in adults. However, there have beenfew studies comparing the effects of proton pump inhibitorsto Hz receptor antagonists for reducing dyspeptic symptoms inchildren.Objective To compare the effect of omeprazole with ranitidinefor reducing dyspeptic symptoms .Methods We performed a double-blind randomized controlledtrial (RCT) at Sardjito Hospital and three community h ealthcenters in the Sleman District from June to November 2012.We recruited children aged 3-18 years with dyspepsia. Subjectswere allocated into two groups using block randomization:the proton pump inhibitor (omeprazole) and the Hz receptorantagonist (ranitidine) groups. According to the groups, eitheromeprazole (0.4-0 .8 mg/kg/dose) or ranitidine (2-4 mg/kg/dose) ,respectively, were taken twice daily for 5 days. Dyspepsia wasclinically diagnosed using the new Rome III criteria. Both groupswere monitored for 5 days to assess for a reduction of dyspepticsymptoms.Results Significantly more subjects in the omeprazole grouprecovered from dyspeptic symptoms than in the ranitidine group(RR= 4.87; 95%CI 1.5 to 15.3; P=0.005).Conclusion Omeprazole was 4.87 (95% CI 1.5 to 15.3) timesbetter than ranitidine in reducing dyspeptic symptoms on childrenaged 3-18 years with dyspepsia.
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Kotecha, Ravi, and Vishwa Kotecha. "Cholelithiasis and laparoscopic cholecystectomy: identifying the appropriate time for operative intervention." International Surgery Journal 8, no. 9 (August 27, 2021): 2600. http://dx.doi.org/10.18203/2349-2902.isj20213269.
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Background: Cholelithiasis is the most common among hepatobiliary disease and often requires surgical intervention. Laparoscopic cholecystectomy is the gold standard nowadays. This research paper was done to know appropriate time for laparoscopic cholecystectomy and how much improvement will we get after laparoscopic cholecystectomy.Methods: In our prospective observational study, 118 patients of cholelithiasis, 59 with dyspepsia in one group and 59 without dyspepsia in another group were taken. Both groups patients were analysed with Bucklay validated dyspeptic score before and after laparoscopic cholecystectomy till 6 months postoperatively for score improvement.Results: In our study, we confirmed that there was improvement in Buckley validated dyspeptic score in both group of patients with dyspepsia and without dyspepsia 6 month after laparoscopic cholecystectomy but not complete improvement. Improvement in Buckley validated dyspeptic score 6 months after laparoscopic cholecystectomy was more in patients with less duration of symptoms and less frequency of episode preoperatively and in non-dyspeptic patients.Conclusions: We could conclude that even earlier surgery after onset of symptoms didn’t result in complete resolution of symptoms in both groups particularly in group B (patients with dyspepsia). We can say that weather it is dyspeptic or non-dyspeptic gallstone disease, it has benefit from laparoscopic cholecystectomy but we can also say that improvement achieved is not complete as after laparoscopic cholecystectomy there were still number of patients who had Buckley validated score more than 6 in both groups after 6 months of surgery.
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MAHESAR, M., SA BHUTTO, WS BHATTI, GR BHURGRI, U. FATIMA, M. CHANDIO, S. MANGI, et al. "ASSESSMENT OF DIETARY AND LIFESTYLE FACTORS ASSOCIATED WITH DYSPEPSIA: A QUESTIONNAIRE-BASED STUDY." Biological and Clinical Sciences Research Journal 2024, no. 1 (January 19, 2024): 668. http://dx.doi.org/10.54112/bcsrj.v2024i1.668.
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The main aim of this study was to better understand the connections between diet patterns and lifestyle choices and the development of dyspepsia providing useful insights into the impact of various dietary and lifestyle components on dyspeptic symptoms, contributing to the creation of focused interventions and recommendations for maintaining digestive health. Among the Pakistani general population, a cross-sectional study was carried out in November 2022. Demographic data, dietary lifestyle factors and frequency of dyspepsia were evaluated. An English-based questionnaire was distributed through Google form. A question related to assessing the dyspepsia frequency in participants and to examining lifestyle factors related to diet (various food consumption consisting of salty food, fast food or any beverages), alcohol consumption, smoking, use of (NSAIDS) medications and utilization of any other home remedies. The sample size of the participants was 351. An SPSS version 25 was used for data analysis. It was observed that 19% of participants were suffering from dyspepsia. Fast food, smoking, painkillers, salty food, and stress were associated with dyspepsia whereas H. pylori, consumption of alcohol and other factors are less likely responsible for dyspepsia. Dietary factors like beverages, tea/coffee, fruits/vegetables and physical activity indicate no significant relation with dyspepsia. It was observed through this study that 14% and 18 % of people were utilizing herbal medicines and home remedies for dyspepsia respectively. However, depression and inadequate sleep had a significant impact on dyspepsia. After a thorough examination of participant data, we were able to identify several significant correlations that offer important information about the possible causes of dyspeptic symptoms.
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Yeom, Jung Sook, Myung Bum Choi, Ji-Hyun Seo, Ji Sook Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, et al. "Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia." Cephalalgia 33, no. 5 (January 4, 2013): 323–29. http://dx.doi.org/10.1177/0333102412472070.
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Background Although many patients with functional dyspepsia experience headache concurrently with dyspeptic symptoms, studies suggesting mechanisms underlying this phenomenon are limited. Herein, we explore the relationship between gastrointestinal inflammatory cells and presence of headache associated with dyspeptic symptoms in children with Helicobacter pylori-negative functional dyspepsia. Methods Fifty-six patients with H. pylori-negative functional dyspepsia underwent upper endoscopy with biopsy to investigate recurrent epigastric pain or discomfort. Patients were divided into two groups according to self-reported presence of headache associated with dyspeptic symptoms. Inflammatory cells including mast cells, and enteroendocrine cells in the gastroduodenal mucosa were evaluated. Associations between headache presence and cellular changes in the gastroduodenal mucosa were examined. Results Headache was not associated with the grade of lymphocytes, neutrophil infiltration, or enteroendocrine cell density in the gastroduedenal mucosa. However, headache was significantly associated with high mast cell density in the body (27.81 ± 8.71 vs. 20.30 ± 8.16, p < 0.01) and duodenum (23.16 ± 10.40 vs. 14.84 ± 5.88, p < 0.01). Conclusions Presence of headache associated with dyspeptic symptoms is strongly related to mucosal mast cell density in pediatric patients with H. pylori-negative functional dyspepsia. Thus, our results may help clinicians understand and treat headache during dyspeptic symptoms in such pediatric patients.
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Nessa, Azizun, Muhammad Rabiul Hossain, Md Habibur Rahman, SM Mizanur Rahman, Abdullah Al Mamun, and Javed Mahfuj Khan. "Evaluation of 105 Cases of Dyspepsia by Upper Gastrointestinal Endoscopy and Ultrasonography of Hepatobiliary System in a Rural Setting." Journal of Armed Forces Medical College, Bangladesh 11, no. 2 (January 16, 2019): 25–29. http://dx.doi.org/10.3329/jafmc.v11i2.39819.
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Introduction: Dyspepsia affects up to 40% of the general population and significantly reduces the quality of life. Dyspeptic symptoms may be associated with endoscopically negative conditions, such as functional dyspepsia, or with organic lesions like peptic ulcer and oesophagitis which are easily detected by endoscopy. On the other hand, such lesions may also be asymptomatic and there is not always a clear cause and effect relationship between endoscopic findings and symptoms.
Objective: To determine the prevalence of significant endoscopic lesion and or ultrasonographic findings and their association with dyspeptic symptoms in Bangladeshi rural population.
Materials and Methods: This prospective cross sectional study was carried out in Nov 2015 to Dec 2015 in a field mobile hospital of Bangladesh Army, established in Daudkandi, Comilla where total 1094 uninvestigated dyspeptic patients were invited to participate in this cross sectional study and 105 typical dyspeptic patients were finally recruited as per Rome III criteria. Participants underwent clinical assessment through a preformed structured questionnaire and non video upper gastrointestinal endoscopy (UGIE) and ultrasonogram (USG) of hepatobiliary system (HBS).
Results: The mean age of 105 participants (male-29; female-76) studied was 36.51±7.26 years with female preponderance (72.38%). Predominant symptoms were epigastric pain (69.52%), flatulence (34.28%), heart burn (28.57%) and diffuse abdominal pain (22.85%). Regarding treatment 48(45.71%) patients took proton pump inhibitors (PPI), 24 patients (22.85%) took H2 receptor blocker and 13 patients (12.38%) were on antacids irregularly. Seventeen patients (16.15%) had no history of medications for dyspepsia. Most of the patients (76.19%) had symptoms of less than 5 years. Organic dyspepsia was found in 68(64.76%) and functional dyspepsia in 37(35.23%) participants. Percentage of functional dyspepsia in male was 24.13% and in female it was 39.47% and the difference was statistically significant (p<0.05). In the organic dyspepsia group, upper GI endoscopy revealed 07(6.66%) duodenal ulcer, 02(1.9%) gastric ulcer, 04(3.8%) prepyloric ulcer and other inflammatory lesions like prepyloric gastritis in 46(43.80%) patients, antral gastritis in 06(5.7%) patients, duodenitis in 08(7.61%) patients and erosive oesophagitis in 03 patients(2.86%). Further USG revealed cholelithiasis in 02(1.90%) and gall bladder (GB) polyp in 01(0.95%) participants which could be the reason for their dyspeptic symptoms. Thirty Seven (35.23%) participants had normal UGIE (and also normal USG of HBS) but they had significant dyspeptic symptoms.
Conclusion: Most of the patients (64.76%) in this study had significant upper GI endoscopic findings and labeled as organic dyspepsia and combined use of upper GI endoscopy and USG of HBS provided better yield for aetiological diagnosis of dyspepsia if there is any.
Journal of Armed Forces Medical College Bangladesh Vol.11(2) 2015: 25-29
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Yasuda, Kohei, Daisuke Chinda, Tadashi Shimoyama, Tetsu Arai, Kazuki Akitaya, Sae Fujiwara, Hiroki Nomiya, et al. "Factors Predicting Effectiveness of Eradication Therapy for Helicobacter pylori-Associated Dyspepsia Symptoms." Life 14, no. 8 (July 25, 2024): 935. http://dx.doi.org/10.3390/life14080935.
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Functional dyspepsia is distinguishable from Helicobacter pylori-associated dyspepsia. However, distinguishing H. pylori-associated dyspepsia from functional dyspepsia before H. pylori eradication is difficult. Therefore, in the present study, we aimed to investigate whether serum pepsinogen levels before H. pylori eradication are associated with the amelioration of dyspepsia after successful H. pylori eradication. Additionally, we examined the usefulness of serum pepsinogen levels and other factors in predicting dyspepsia outcomes. H. pylori eradication was effective in 14 patients (Responders) and ineffective in 19 patients (Non-responders). The pepsinogen I/II ratio in Responders (3.4 ± 1.2) and Non-responders (2.3 ± 1.0) differed significantly (p = 0.006). The optimal cut-off pepsinogen I/II value was 2.3. Multivariate logistic regression analysis showed that the adjusted odds ratio for Non-responders was 26.1 (95% confidence interval: 2.0–338.0, p = 0.012) for a pepsinogen I/II ratio ≤ 2.3 and 8.10 (95% confidence interval: 1.1–57.6, p = 0.037) for smoking habits. The pepsinogen I/II ratio and smoking habits were associated with the effects of H. pylori eradication on dyspeptic symptoms. Thus, the pepsinogen I/II ratio cut-off value can be used to identify patients likely to respond to H. pylori eradication after the resolution of dyspeptic symptoms.
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Zhestkova, T. V. "Evaluation of the dynamics of symptoms of dyspepsia after eradication therapy in patients with Helicobacter pylori-associated gastritis." Experimental and Clinical Gastroenterology, no. 10 (January 18, 2023): 14–18. http://dx.doi.org/10.31146/1682-8658-ecg-206-10-14-18.
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The treatment of functional dyspepsia remains a complex and incompletely resolved issue of gastroenterology. Subjective sensations of the patient, described as a feeling of fullness in the epigastrium after eating, early satiety, pain in the epigastrium, may be a manifestation of dyspepsia associated with Helicobacter pylori (H. pylori) infection. Aim was evaluation of the effectiveness of standard triple eradication therapy enhanced with bismuth tripotassium dicitrate for the relief of symptoms of dyspepsia in patients with H. pylori-associated chronic gastritis. Materials and Methods. The study involved 38 patients with H. pylori-associated chronic gastritis with symptoms of dyspepsia. The Questionnaire “7 × 7” was used to describe the dynamics of symptoms of dyspepsia. Results. At the initial examination, dyspeptic disorders in most patients corresponded the criteria for mild and moderate severity, respectively - 44.7% and 28.9% of patients. The severity of pain in the stomach area on average corresponded to a moderate pain syndrome, and the burning sensation was of low intensity. A feeling of fullness in the stomach after eating and/or early satiety was experienced by 76.3% of patients, pain disorders were observed in 92.1% of individuals. Two months after successful eradication treatment, complete relief of dyspepsia symptoms was noted in 57.9% of patients, and significant relief of symptoms of the combined form of dyspepsia in 23.7% of individuals. Conclusions: Successful standard triple eradication therapy enhanced with bismuth tripotassium dicitrate is effective for the treatment of dyspeptic symptoms in patients with H. pylori-associated chronic gastritis.
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Hakim, Gözde Derviş, Şafak Kızıltaş, Hilmi Çiftçi, Şafak Göktaş, and İlyas Tuncer. "The Prevalence of Giardia Intestinalis in Dyspeptic and Diabetic Patients." ISRN Gastroenterology 2011 (July 27, 2011): 1–4. http://dx.doi.org/10.5402/2011/580793.
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Background and Aims. We aimed to investigate the prevalence of Giardiasis in patients with dyspepsia and patients with diabetes mellitus. Methods. 400 patients and 100 healthy persons were included in this clinical prospective study. The number of patients in each group was equal, 200 dyspeptic and 200 diabetic, respectively. The antigen of G. lntestinalis was determined in the stool specimens by ELISA method. Results. The frequency of Giardiasis was 7% in dyspeptic and 15% in diabetic patients. There was no positive results in any of the healthy persons. There was a significant difference in prevalence rate of Giardiasis between patients with dyspepsia and diabetes mellitus (P<0.05). Conclusions. These results revealed that the prevalence of Giardiasis in dyspepsia and with diabetes mellitus was high in our country. This is the first study investigating the prevalence of Giardiasis in diabetic patients. To investigate Giardiasis in diabetic patients, who have dyspepsia or not, may be a good approach for public health.
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Shrestha, Rishab, Gaurav Chhetri, Arbind Deo, and Rabindra Nath Das. "A descriptive cross-sectional study of helicobacter pylori infection in non-ulcer dyspepsia patients in a tertiary care teaching hospital In the Eastern part of Nepal." Journal of Nobel Medical College 5, no. 2 (December 26, 2016): 10–16. http://dx.doi.org/10.3126/jonmc.v5i2.16309.
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Background In Gastroenterology practice, worldwide, the most common cause of dyspepsia is functional. Functional or non-ulcer dyspepsia is established by gastroduodenoscopy which rules out structural disorders in dyspeptic patients. Helicobacter pylori, a gram-negative bacterium in gastric mucosa is associated with non-ulcer dyspepsia, chronic gastritis, gastriculcer and cancer. Worldwide prevalence of Helicobacter pylori infection is higher but its association with non-ulcer dyspepsia is less clear.Material and Methods The aim of this study was to see the prevalence of H. pylori infection in non-ulcer dyspepsia. A cross-sectional study of 340 patients presented at Nobel Teaching Hospital in one year with dyspeptic symptoms underwent clerking, physical examination, gastroduodenoscopy and RUT. Symptomatic patients without any structural lesions were designated as functional dyspepsia. RUT when turned red indicated positive for H. pylori infection.Result Out of 340 patients, 180 (52.9%) were female and 160(47.1%) were male. Mean age of male and female patients was 35.88 ± 11.8 and 38.11 ± 11.7 respectively. Amongst all participants 150 (44.11%) were housewives and 69(20.3%) were students. Endoscopic findings showed gastritis 205(60.29%) and duodenitis 15(4.42%). RUT was found positive in 62% of gastritis and 86.7% of duodenitis patients (p value=0.001).Conclusion High prevalence of H pylori infection in present study may be one of the causative factors in producing symptomatic non-ulcer dyspepsia. Hence, early detection and complete eradication of H.pylori infection is mandatory. It will reduce usage of PPIs and also improve quality of life.Journal of Nobel Medical College Vol.5(2) 2016; 10-16
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Zahra, Farrukh, Muhammad Younis, and Uzma Nisar. "NONULCER DYSPEPSIA." Professional Medical Journal 23, no. 08 (August 10, 2016): 907–11. http://dx.doi.org/10.29309/tpmj/2016.23.08.1661.
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Objectives: To determine the frequency of nonulcer dyspepsia in patientspresenting with the peptic ulcer like symptoms and to determine the effect of H. pylori eradicationon dyspeptic symptoms and the effect of six weeks trial of proton pump inhibitor as treatmentmeasure. Study design: Cross-sectional study. Setting: Combined Military hospital Quetta,Department of medicine. Period: Six months from Oct, till March 2009. Subjects and Methods:Patients coming to medicine department with complaints of dyspepsia. Results: Total no ofpatients were 145 out of which male were 90 while 55 were females. The mean age was 29.68+ 4.53. These subjects were given H pylori eradication therapy and response was graded aspatients responded or no response. 89 subjects (61.4%) responded to H pylori eradicationtreatment while 56 subjects (38.6%) showed no symptomatic benefit. Non responder toeradication i.e., 37 males and 36 females were given further six week treatment with omeprazole,and subjective response to treatment was graded as complete resolution found in 31 patients (21.4% ), while partial resolution was present in 15 patients (10.3%). 07 patients (4.8%) showedno improvement while 03 patients (2.1%) showed worsening of symptoms. Conclusions: Theprevalence of non-ulcer dyspepsia is high among symptomatic individuals. The response toH pylori eradication was significant. Non responders also showed considerable symptomaticbenefit with PPI. Therefore, individuals with recurrent dyspeptic symptoms should be given trialof H. pylori eradication.
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Saenglootong, Lickhasit, and Somchai Insiripong. "Chronic Dyspepsia Due to an Unusual Cause Outside the Gastrointestinal Tract: A Case Report." Ramathibodi Medical Journal 42, no. 4 (December 31, 2019): 78–82. http://dx.doi.org/10.33165/rmj.2019.42.4.136668.
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The majority of cases with dyspepsia usually have normal gastroscopic finding, so some unusual causes may be easily neglected under the umbrella of nonulcer dyspepsia as in this case. We report a 64-year-old Thai patient who suffered from dyspepsia and fatigue for many years. Her latest physical examination was unremarkable. Although she did not have any warning signs, many abdominal investigations including the ultrasonography, computerized tomography, barium enema with air contrast, esophagogastroduodenoscopy, and colonoscopy were repeatedly performed in different hospitals and all revealed unremarkable. The last esophagogastroduodenoscopy showed only mild acute gastritis that was not expected to account for the many-year dyspepsia and fatigue. The unusual and rare causes of long term dyspepsia were extensively investigated. Finally, she was found to have serum cortisol less than 0.8 , normal serum calcium, phosphorus, and electrolytes but minimally abnormal thyroid function test. Therefore, she was diagnosed as having adrenal insufficiency and concurrent subclinical hyperthyroidism. She was fully treated with many dyspeptic drugs such as pantoprazole, sucralfate, simethicone, ondansetron, and intravenous hydrocortisone infusion 300 mg a day. She responded well to therapy in 2 days and was discharged home with oral prednisolone 15 mg a day with many dyspeptic drugs. Adrenal insufficiency is a very rare entity and most cases have no specific signs and symptoms, so it could be easily overlooked as the very rare and unusual cause of chronic dyspepsia. In this report, the association between the adrenal insufficiency and the gastrointestinal upset is discussed.
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McColl, K. E. L., A. El-Nujumi, L. S. Murray, E. M. El-Omar, A. Dickson, A. W. Kelman, and T. E. Hilditch. "Assessment of symptomatic response as predictor ofHelicobacter pylori status following eradication therapy in patients with ulcer." Gut 42, no. 5 (May 1, 1998): 618–22. http://dx.doi.org/10.1136/gut.42.5.618.
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Background—Helicobacter pylorieradication therapy is routinely used for treating patients with peptic ulcer disease.Aims—To assess the value of symptomatic response to H pylori eradication therapy as a marker of post-treatment H pylori status.Patients and methods—One hundred and nine dyspeptic patients with active duodenal or gastric ulceration associated with H pylori infection had their symptoms measured by a validated questionnaire before and three months followingH pylori eradication therapy. The symptomatic response was compared with post-treatment H pylori status as determined by the 14C urea breath test.Results—An eradication rate of 84% was achieved. Of the 92 patients eradicated of H pylori, 47% experienced complete or near complete resolution of dyspepsia. Of the 17 patients in whom the infection was not eradicated, only one (6%) experienced resolution of dyspepsia. Resolution of dyspepsia was therefore a powerful predictor of eradication of H pyloriwith a predictive value of 98%. In contrast, persistence of dyspepsia was a weak predictor of persisting infection with a predictive value of only 25%. Excluding patients with endoscopic evidence of coexisting oesophagitis and/or retrosternal discomfort or reflux at initial presentation did not increase the predictive value of persisting dyspepsia for persisting infection.Conclusions—Complete resolution of dyspeptic symptoms is a powerful predictor of eradication of H pylori infection in ulcer patients. Persistence of symptoms is a weak predictor of persisting infection and patients with persisting dyspepsia must have their H pylori status rechecked to guide future management.
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Costa, Michelle Bafutto Gomes, Itaciron Luz Azeredo Jr., Ricardo Duarte Marciano, Luciana Morelli Caldeira, and Mauro Bafutto. "Evaluation of small intestine bacterial overgrowth in patients with functional dyspepsia through H2 breath test." Arquivos de Gastroenterologia 49, no. 4 (December 2012): 279–83. http://dx.doi.org/10.1590/s0004-28032012000400009.
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CONTEXT: Functional dyspepsia is a condition in which symptoms are not related to organic underlying disease; its pathogenesis is not well known. The small intestinal bacterial overgrowth (SIBO) is characterized by the increase in the number and/or type of colonic bacteria in the upper gastrointestinal tract. The hypothesis of SIBO being associated to functional dyspepsia must be considered, since the impaired motility of the gastrointestinal tract is one of the main etiologic factors involved on both pathologies. OBJECTIVE: To determine if there is SIBO in patients with functional dyspepsia. METHODS: Case-control study, evaluating 34 patients: 23 functional dyspeptic and 11 non-dyspeptic (control group). Questionnaire applied based on Rome III criteria. The patients underwent H2-lactulose breath test, considered positive when: H2 peak exceeding 20 ppm, in relation to fasting, or two peaks exceeding 10 ppm sustained until 60 minutes. RESULTS: Of the 23 dyspeptic patients, 13 (56.5%) obtained positive results for SIBO trough the H2-lactulose breath test. On control group, SIBO was not observed. The association between the dyspeptic group and the control group regarding SIBO was statistically significant, with P = 0.0052. In the group of dyspeptic patients, 12 (52.2%) were using proton pump inhibitor; of these 9 (75%) were positive for SIBO. In the control group, none of the 11 patients used proton pump inhibitors and SIBO was not observed. The association of the dyspeptic group using proton pump inhibitor that were positive for SIBO and the control group was statistically significant, with P = 0.0011. CONCLUSION: It was found that, patients with functional dyspepsia presented SIBO, when they underwent to H2-lactulose breath test, compared to the non-dyspeptic. In addition, it was observed a higher prevalence of SIBO in dyspeptic patients that were using proton pump inhibitors, compared to control group.
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K., Thyagaraja, Venkatakrishna Bhat S., and Stephan Benny. "Endoscopic findings in uninvestigated dyspepsia patients." International Journal of Advances in Medicine 6, no. 4 (July 24, 2019): 1051. http://dx.doi.org/10.18203/2349-3933.ijam20193254.
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Background: Dyspepsia is a frequent syndrome in our country where there are limitations for endoscopy and there is high burden of H. pylori infection. It is important to establish the causes of dyspepsia hence therapeutic approach will be easier. Aim of the study was to find out the common endoscopic findings in a patient with dyspepsia symptoms large tertiary care hospital.Methods: A cross-sectional study was conducted on 184 patients either admitted or seen on outpatient basis at the Basaveswara medical college and research institute, Chitradurga with the upper GI symptom dyspepsia and the data was analysed using appropriate statistical methods.Results: Out of 184 patients who underwent Esophagogastroduodenoscopy (EGD scopy) 62% were male and 61% were 31-59year old. The common pathological findings in dyspeptic patients were gastritis and esophagitis.Conclusions: The following insights/observations were made during the course of this study→ dyspepsia is usually caused by H. pylori gastritis, eradication of which relieves the symptom in this observation. Many a times dyspepsia found to have normal study. Hence wise referral for endoscopy is a key in resource limited setup.
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Swami, Onkar C., and Neel J. Shah. "Functional dyspepsia and the role of digestive enzymes supplement in its therapy." International Journal of Basic & Clinical Pharmacology 6, no. 5 (April 24, 2017): 1035. http://dx.doi.org/10.18203/2319-2003.ijbcp20171653.
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Functional dyspepsia represents a heterogeneous group of gastrointestinal disorders marked by the presence of upper abdominal pain or discomfort. Reported prevalence of dyspepsia in the world varies from 11-30%. Basic Pathophysiology of functional dyspeptic symptoms is unclear and is considered to occur due to a combination of visceral hypersensitivity, gastric motor dysfunction and psychological factors. Strategies such as acid suppression, prokinetics and H. pylori eradication have been used with some success. Transient deficiency in digestive enzymes is one of the contributors for functional dyspepsia. The primary digestive enzymes are proteases, amylases and lipases. A commonly used therapeutic approach in its treatment is the use of oral enzymes supplementation therapy. Commercially, digestive enzymes are obtained from plant, animal and microbial sources. This review summarizes the pathophysiology of functional dyspepsia, different pharmacological approaches and focuses on the safety and efficacy of digestive enzymes in managing dyspepsia. Keywords including functional dyspepsia, digestive enzymes, lipase, diastase, papain, pepsin, trypsin and chymotrypsin were searched in databases such as Google, Google Scholar, PubMed, pharmacopoeia and textbooks.
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Chiba, Naoki, Lisa Bernard, Bernie J. O’Brien, Ron Goeree, and Richard H. Hunt. "A Canadian Physician Survey of Dyspepsia Management." Canadian Journal of Gastroenterology 12, no. 1 (1998): 83–90. http://dx.doi.org/10.1155/1998/175926.
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OBJECTIVE: To determine the management of patients with new onset dyspepsia by Canadian family physicians.METHODS: A survey was mailed to 195 family physicians in August 1995 to identify how they manage dyspepsia in patients according to four scenarios: based on presenting symptoms alone; assumingHelicobacter pylori-positive; known to beH pylori-negative; and endoscopically confirmed nonulcer dyspepsia.RESULTS: A total of 170 of 195 physicians (87.2%) completed the survey. Physicians reported that 7.3% of their practice is devoted to dyspepsia and 23% of these dyspeptic patients present for the first time. Ninety-three per cent of family physicians find a symptom classification of ulcer-, reflux- and dysmotility-like dyspepsia helpful. The majority of patients are advised to make lifestyle changes and are treated with antacids or empiric drug therapy. A H2receptor antagonist was the drug of choice for ulcer and reflux-like dyspepsia, while prokinetics were often used for reflux and dysmotility-like dyspepsia. After failure of initial treatment, patients were given another course of empiric treatment, commonly with cisapride or omeprazole. Family physicians estimated that the mean time to obtain a gastrointestinal consult was five weeks, and 70% indicated that this time to consult adversely influenced their decision to refer. If this time was reduced to less than two weeks, responding physicians would consider referring all eligible patients. On average, two to 2.5 courses of empiric therapy were given before referral. IfH pyloristatus was known, fewer empiric treatments (mean 1.8) were given before gastroenterological referral compared with the other scenarios. If the patient had nonulcer dyspepsia, 30% of family physicians provided reassurance only and did not prescribe empiric drug treatment.CONCLUSIONS: Most newly dyspeptic patients in Canada are treated with empiric therapy according to symptom classification and referred for endoscopy after an average two to 2.5 treatment courses.
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Shklyaev, A. E., A. A. Shutova, A. G. Bessonov, and K. V. Maksimov. "Features of manifestations of functional dyspepsia in medical students of different years of study." Experimental and Clinical Gastroenterology, no. 9 (September 18, 2020): 24–28. http://dx.doi.org/10.31146/1682-8658-ecg-181-9-24-28.
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Objective of the study: to clarify the influence of external factors on the symptoms of functional dyspepsia in medical students.Materials and methods: A survey of 105 students aged 20.2 ± 0.18 years was conducted. The survey was conducted on a special gastroenterological questionnaire GSRS. Also in the questionnaire we added questions that characterize postprandial distress syndrome. An additional questionnaire was conducted on issues that allow us to assess the influence of external factors on the functional dyspepsia of students (nutrition, bad habits, constitutional features).Results: During the study revealed: the intensity of manifestations of functional dyspepsia from 1 to 6 courses is reduced. Bad habits like smoking, eating at bedtime, using chewing gum, eating with alcohol have a negative effect on the digestive system, which can be a risk factor for developing functional dyspepsia. A correlation was also found between clinical syndromes: epigastric pain syndrome and reflux syndrome (r = 0.4), diarrhea syndrome (0.37), dyspeptic syndrome (0.5), constipation syndrome (0.37); postprandial distress syndrome and reflux syndrome (0.42), diarrhea syndrome (0.39), dyspeptic syndrome (0.83), constipation syndrome (0.39).Conclusions: The intensity of most manifestations of functional dyspepsia during the transition to older courses decreases, however, 4-year students are more susceptible to postprandial distress syndrome, which can be associated with adverse factors such as smoking, eating food at bedtime, using chewing gum, eating with alcohol.
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Chukwurah, Shirley Nneka, Felix Emeka Menkiti, Chinyelu Uchenna Ufoaroh, Ogochukwu Chioma Ofiaeli, Chisom God’swill Chigbo, and A. O. Aloysius Odili Okoye. "Clinical, Endoscopic and Histopathological Patterns among Patients with Dyspepsia." Asian Journal of Medicine and Health 21, no. 9 (July 5, 2023): 154–65. http://dx.doi.org/10.9734/ajmah/2023/v21i9869.
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Aim: Dyspepsia is a term differently understood, and associated with various upper gastro-intestinal endoscopic and histopathologic patterns. Most patients have regarded upper abdominal pain as ‘peptic ulcer disease’ with resultant late presentation of upper gastro-intestinal malignancies in some cases. This study examined the clinical presentation, endoscopic and histopathological patterns among patients with dyspeptic symptoms in Nnewi, South-East Nigeria.
Methods: This hospital based descriptive cross-sectional study examined 352 patients presenting with dyspepsia. Abdominal ultrasound was used to exclude patients with dyspepsia of biliary or pancreatic origin. An interviewer administered questionnaire (using the short form Leeds dyspepsia questionnaire) was used to describe dyspepsia patterns, and gastroscopy done on the included patients following an overnight fast. Samples obtained from endoscopy were assessed histologically for morphology and presence of H. pylori organism.
Results: Most participants belonged to 55 to 74 years age group with a mean age of 52.27±2.59 years. Epigastric discomfort (96.9%), heart burn (63.1%) and belching (55.4%) were the commonest symptoms. The commonest endoscopy and histopathologic findings was chronic gastritis (63.06% and 51.99% respectively), although there was poor agreement between the two modalities.
Conclusion: Histology remains the goal standard for diagnosis. However, we recommend endoscopy for dyspeptic patients especially in the elderly to enhance early detection of cancers, which were significant in this study.
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Uspenskiy, Yury P., and Natalia V. Baryshnikova. "Functional dyspepsia and chronic gastritis." Pediatrician (St. Petersburg) 9, no. 1 (March 15, 2018): 77–83. http://dx.doi.org/10.17816/ped9177-83.
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Diseases of upper parts of digestive tract are extremely widespread pathology and have not only the medical, but also social importance since often occur at young working-age people. It is actual to separate the items: functional dyspepsia (FD) and a dyspepsia associated with Helicobacter pylori because it is important for optimization of patient’s treatment. The review of modern foreign and Russian references about treatment of dyspeptic patients depending on existence or absence of an infection of Helicobacter pylori is presented in article (recommendation of V Maastricht consensus, Kyoto consensus, Russian gastroenterological association, Science society of Russian gastroenterologists). At diagnosis of a functional dyspepsia, it is recommended to be guided by the Roman criteria of the IV revision. In with document not only importance of an exception of organic pathology of digestive tract as the reasons of a secondary dyspepsia, but also need of inspection for the purpose of verification of Helicobacter pylori for an exception of an etiological role of a microorganism in development of a dyspepsia is emphasized. Allocation of two clinical options of a functional dyspepsia is also proved from the point of view of approaches to therapy of this disease. Algorithms of treatment of patients with various options of a dyspepsia are presented in article. These algorithms include different schemes of eradication therapy in case of dyspepsia associated with Helicobacter pylori and prokinetics/acid suppressors in case of functional dyspepsia.
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Sosnina, Valentina Sergeevna, and Zhanna Georgievna Simonova. "CHARACTERISTICS OF DYSPEPTIC SYNDROME IN HEMODIALYSIS PATIENTS." Ulyanovsk Medico-biological Journal, no. 2 (June 28, 2024): 66–77. http://dx.doi.org/10.34014/2227-1848-2024-2-66-77.
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The goal of the paper is to study characteristics of dyspeptic syndrome in hemodialysis patients receiving renal replacement therapy. Materials and Methods. During an open clinical trial, we formed a group of hemodialysis patients (n=50) with end-stage chronic kidney disease (CKD C5). All patients were assessed for the clinical manifestations, dyspeptic syndrome severity, and laboratory data. All patients underwent esophagogastroduodenoscopy (EGDS). Results. All 50 (100 %) patients included in the study had dyspeptic syndromes. The most common symptoms were nausea (46 %), belching (44 %), and heartburn (38 %). At the same time, 56 % of patients had high dyspepsia index. When analyzing the correlation between dyspepsia index and dialysis therapy,a direct connection was established (ρ=0.281, p=0.048). It was revealed that the dialysis therapy duration impacted the dyspepsia index. The most common pathology of the upper gastrointestinal tract was chronic gastritis, diagnosed in 84 % of patients. Chronic duodenitis was found in 50 % of patients, and gastroduodenal ulcer was observed in 6 % of patients. Conclusion. Hemodialysis patients receiving renal replacement therapy are at risk for dyspeptic syndrome accompanying upper gastrointestinal tract organic pathology. Early detection of dyspeptic syndrome in hemodialysis patients is of great importance for the timely diagnostic and corrective therapeutic measures.
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Hunt, Richard H., Carlo Fallone, Sander Veldhuyzen van Zanten, Phil Sherman, Nigel Flook, Fiona Smaill, Alan BR Thomson, and the Canadian Helicobacter Study Group. "Etiology of Dyspepsia: Implication for Empiric Therapy." Canadian Journal of Gastroenterology 16, no. 9 (2002): 635–41. http://dx.doi.org/10.1155/2002/679683.
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Dyspepsia describes a symptom complex thought to arise in the upper gastrointestinal tract and includes, in addition to epigastric pain or discomfort, symptoms such as heartburn, acid regurgitation, excessive burping or belching, a feeling of slow digestion, early satiety, nausea and bloating. Based on the evidence that heartburn cannot be reliably distinguished from other dyspeptic symptoms, the Rome definition appears to be too narrow and restrictive. It is particularly ill suited to the management of uninvestigated dyspepsia at the level of primary care. In patients presenting with uninvestigated dyspepsia, a symptom benefit is associated with a ‘test and treat’ approach forHelicobacter pyloriinfection. A substantial proportion of those who do not benefit prove to have esophagitis on endoscopy. In those with functional dyspepsia, the benefits ofH pylorieradication, if any, appear to be modest. Hence, a "symptom and treat" acid-suppression trial with proton pump inhibitors, and a ‘test and treat’ strategy forH pyloriare two acceptable empirical therapies for patients with univestigated dyspepsia.
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Sheptulin, A. A., O. A. Storonova, and D. E. Rumyantseva. "Consensus Meeting of European Society of Neurogastroenterology and Motility on Functional Dyspepsia (2020): Have We Dotted All the I’s?" Russian Journal of Gastroenterology, Hepatology, Coloproctology 31, no. 2 (June 2, 2021): 40–45. http://dx.doi.org/10.22416/1382-4376-2021-31-2-40-45.
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Aim. A review of the agreement issued by the European Society of Neurogastroenterology and Motility consensus meeting on functional dyspepsia in 2020.Key points. Expert votes at the consensus meeting generally confirmed the main statements of the Rome Criteria Revision IV on the definition of functional dyspepsia, its aetiology and pathogenesis, diagnosis and treatment, as well as those of the Kyoto Consensus covering the possible association of dyspeptic complaints with H. pylori infection. An absent consensus on certain statements, especially in drug efficacy evaluation, demonstrates insufficient knowledge of many issues in disease.Conclusion. Functional dyspepsia demands further investigation.
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Harianto, Indro, and Jane Netta Meilia. "Pengaruh Karakteristik Individual yang Mempengaruhi Gejala Dispepsia Akibat Stress Akademik pada Mahasiswa Selama Masa Pandemi COVID-19." Surya Medika: Jurnal Ilmiah Ilmu Keperawatan dan Ilmu Kesehatan Masyarakat 17, no. 1 (December 25, 2021): 7–16. http://dx.doi.org/10.32504/sm.v17i1.450.
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ABSTRACT Background of Study: Functional dyspepsia is a symptom of discomfort in the upper abdomen, feeling full quickly, burning and bloating. Dyspepsia is closely related to psychological factors such as stress because the gastrointestinal tract is very responsive to emotional stimuli and stress. Common stress among students is academic stress. This study aims to determine the effect of individual characteristics with dyspepsia symptoms and the emergence of dyspeptic symptoms due to academic stress during the COVID-19 pandemic. Methods: This study used a cross-sectional method to 192 University of Surabaya students taken from 8 faculties with consecutive sampling technique. The statistical test used is the sci-square test and the Spearman Rank correlation test. Results: There was a correlation between the level of academic stress and the incidence of functional dyspepsia in University of Surabaya students with the results of the Spearman Rank correlation test ((P value = 0.000) 0.10) and the correlation number of r = + 0.464 indicating a moderate correlation. Conclusion: There was an influence of individual characteristics (age, gender, faculty, and semester) with dyspepsia symptoms and the emergence of dyspepsia symptoms due to academic stress during the COVID-19 pandemic in students in Surabaya. Keywords: Dyspepsia, students, academic stress
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Hidayat, Rahmat, Agung Susanto, and Anik Lestari. "Literature Review: The Relationship between Eating Habits and Dyspepsia in Adolescents." Amerta Nutrition 7, no. 4 (November 28, 2023): 626–37. http://dx.doi.org/10.20473/amnt.v7i4.2023.626-637.
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Background: All over the world the prevalence of dyspepsia is quite high. Various literature sources in western countries show that the prevalence of dyspepsia Various literature sources in western countries show that the prevalence of dyspepsia is in the range of 7-41% in 2009, but unfortunately only about 10-20% of patients seek treatment or medical help. The increasing condition of dyspepsia can cause various health problems such as decreasing quality of life and functional activity. Dyspepsia usually affects those of productive age. Objectives: This article was produced with the intention of examining the association between eating behaviors and the prevalence of dyspepsia in adolescents. Methods: This is a qualitative article written using a literature study through searches on Google, Google Scholar and Research Gate with the keywords “Eating Patterns and Dyspepsia”, “Types and Frequency of Eating and Dyspepsia”, and “Risk Factors for Dyspepsia”. The resulting articles were selected using the PRISMA flowchart. Results: There are still many teenagers who do not take care of their own health. Teenagers who still live with their parents sometimes still don't care about their health. Adolescents' eating habits, such as eating irregularly or experimenting with an unbalanced diet that is not recommended by health professionals, can lead to unfulfilled nutritional needs. Conclusions: Today's lifestyle of teenagers influences their eating habits. Teenagers who are preoccupied with schoolwork and other activities often delay eating or apply the wrong diet, which if left unchecked can trigger dyspepsia. There is a need for repeated education about the importance of fulfilling nutritional intake through regular eating habits to reduce dyspeptic symptoms.
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Raphael S and Amadi DC. "Histopathological pattern of endoscopic gastric biopsies in dyspeptic patients in a Nigerian population." Ibom Medical Journal 15, no. 3 (September 1, 2022): 209–14. http://dx.doi.org/10.61386/imj.v15i3.265.
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Background and Objective: Dyspepsia is one of the most common complaints encountered in the general outpatient and gastroenterology clinics in Nigeria. Histopathological assessment of endoscopic gastric mucosa biopsy is crucial to delineate the exact cause of dyspepsia to guide patients’ management. This study aimed to determine and document the histopathological basis of dyspepsia among dyspeptic patients at our facility.
Material sand Methods: This was a three year descriptive retrospective study and the materials consisted of all gastric endoscopic biopsies taken from clinically diagnosed dyspeptic patients sent to the Department of Histopathology of the Federal Medical Centre, Owerri, Nigeria.
Results: The biopsies were from 64 (53.2%) male patients and 56 (46.8%) female patients, giving a male to female ratio of 1.14:1. The age range of the patients was 28-82 years with a mean of 56 years at presentation. Helicobacter Pylori (H. Pylori) bacilli were identified in the samples of 42 (35%) patients but absent in samples of 78 (65%) patients. The histopathological pattern of the aetiological basis of dyspepsia in this study consisted of gastritis (96, 80%), functional (17, 14.2%), adenocarcinoma (4, 3.3%) and polyps (3, 2.5%). H. Pylori bacilli were seen only in patients with gastritis (42/96, 43.8%), and it affected 19 (45.2%) male patients and 23 (54.8%) female patients. Chronic active H. Pylori associated gastritis (24, 25%) was the most common form of gastritis seen during the study period.
Conclusion: The main organic cause of dyspepsia in our setting was chronic gastric followed in the distant by gastric adenocarcinoma and polyp. Dyspepsia and H. Pylori associated gastritis did not show a significant gender predilection.
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LASA, Juan, Liliana SPALLONE, Silvina GANDARA, Elsa CHAAR, Saul BERMAN, and David ZAGALSKY. "Celiac disease prevalence is not increased in patients with functional dyspepsia." Arquivos de Gastroenterologia 54, no. 1 (March 2017): 37–40. http://dx.doi.org/10.1590/s0004-2803.2017v54n1-07.
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ABSTRACT BACKGROUND Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. OBJECTIVE To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. METHODS Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies. On the other hand, asymptomatic adult volunteers who performed a preventive visit to their primary care physician were invited to participate and agreed to undertake an upper gastrointestinal endoscopy with duodenal biopsies as well. Those patients with histologic signs of villous atrophy were furtherly evaluated and serological tests were performed in order to determine celiac disease diagnosis. Celiac disease prevalence was compared between groups. RESULTS Overall, 320 patients with dyspepsia and 320 healthy controls were recruited. There were no significant differences in terms of gender or age between groups. Celiac disease diagnosis was made in 1.25% (4/320) of patients in the dyspepsia group versus 0.62% (2/320) in the control group. CONCLUSION Patients with dyspepsia who underwent routine duodenal biopsies did not show an increased risk for celiac disease when compared to healthy individuals.
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Kang, Seung Joo, Boram Park, and Cheol Min Shin. "Helicobacter pylori Eradication Therapy for Functional Dyspepsia: A Meta-Analysis by Region and H. pylori Prevalence." Journal of Clinical Medicine 8, no. 9 (August 28, 2019): 1324. http://dx.doi.org/10.3390/jcm8091324.
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Background: Previous studies on the effect of Helicobacter pylori eradication on functional dyspepsia (FD) are conflicting. We performed a comprehensive meta-analysis on this issue according to region and prevalence of H. pylori. Methods: Randomized controlled trials (RCTs) evaluating the effect of eradication of H. pylori on functional dyspepsia up to December 2018 were searched through PubMed, EMBASE, and the Cochrane Library. Subgroup analyses by the outcome measure, region, and prevalence of H. pylori were performed. All data were analyzed with Review Manager 5.3. Results: Eighteen RCTs were included in our meta-analysis. Overall, the H. pylori eradication group showed significant improvement of symptoms compared with the control group (risk ratio (RR) = 1.18; 95% confidence interval (CI): 1.07–1.30, p < 0.01). There was moderate heterogeneity among studies (I2 = 34%) and the number needed to treat (NNT) was 15.0. Helicobacter pylori eradication improved dyspeptic symptoms both in low (<50%) and high (≥50%) H. pylori prevalence regions (RR = 1.21 and 1.17; 95% CI: 1.02–1.44 and 1.06–1.29, I2 = 49% and 5%, respectively.) In the analysis of studies from Asia, however, the effect of eradication on improvement of dyspepsia was not significant (RR = 1.14; 95% CI: 0.99–1.33, p = 0.08, I2 = 37%). Conclusion: Overall, H. pylori eradication provides significant improvement of symptoms in functional dyspepsia patients regardless of H. pylori prevalence. However, in the analysis of studies from Asia, the eradication did not significantly improve dyspeptic symptoms. In this region, eradication for dyspepsia can be individualized.
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Basavaraju, Sachin Murukanahalli, Mohammed Arshad Ali Khan, Shantala ..., and Abhighna M. "Study of Prevalence of H Pylori Infection in Dyspeptic Patients." New Indian Journal of surgery 12, no. 4 (December 15, 2021): 241–46. http://dx.doi.org/10.21088/nijs.0976.4747.12421.8.
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Background: Helicobacter pylori infection occurs worldwide, affecting more than half of the world population. The clear aetiology of dyspeptic symptoms is still unclear but helicobacter infection is main contributing factor for it we investigated Helicobacter pylori prevalence in dyspepsia. Methods: 100 cases of dyspepsia attended Adichunchanagiri hospital and research center, studied over a period of 18 months (January 2020 to June 2021), were subjected to upper gastrointestinal endoscopy, during which 4 biopsies, two each from the antrum and the pathological areas were taken. Two biopsy specimens, one of the antral area and the other of the pathological finding were immediately inoculated into freshly prepared urea broth containing phenol red as the indicator. Positive test for Helicobacter pylori was indicated by change in colour of the medium from yellow to pink or red. The other two biopsy specimens were sent for routine histopathology. The case was taken as Helicobacter pylori positive when the rapid urease test and/or histopathological examination were positive. Results: Out of 100 dyspeptic patients who were included in the study, there were 65 male patients and 35 female patients. In which 71 patients were found to have been infected with Helicobacter pylori (71%). Conclusion: In this study, we found that in Dyspepsia the Helicobacter pylori was consistently associated and its well proved with various studies done in past and present. Thus we conclude Helicobacter pylori infection definitely have role in the aetiopathogenesis of dyspepsia. Keywords: Giemsa; Helicobacter Pylori; Peptic ulcer disease; Urease; Ulcerative dyspepsia.
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Madsen, Lone Galmstrup, and Peter Bytzer. "The Value of Alarm Features in Identifying Organic Causes of Dyspepsia." Canadian Journal of Gastroenterology 14, no. 8 (2000): 713–20. http://dx.doi.org/10.1155/2000/783950.
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The unaided clinical diagnosis of dyspepsia is of limited value in separating functional dyspepsia from clinically relevant organic causes of dyspepsia (gastric and esophageal malignancies, peptic ulcer disease and complicated esophagitis). The identification of one or more alarm features, such as weight loss, dysphagia, signs of gastrointestinal bleeding, an abdominal mass or age over 45 years may help identify patients with a higher risk of organic disease. This review summarizes the frequency of alarm symptoms in dyspeptic patients in different settings (such as the community, primary care and specialist clinics). The prevalence of alarm features in patients diagnosed with upper gastrointestinal malignancy or peptic ulcer disease is described. The probability of diagnosing clinically relevant upper gastrointestinal disease in patients presenting with alarm features and other risk factors is discussed. Alarm features such as age, significant weight loss, use of nonsteroidal anti-inflammatory drugs, signs of bleeding and dysphagia may help stratify dyspeptic patients and help optimize the use of endoscopy resources.
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Yasin, Zakiyah, Nailiy Huzaimah, and Hariyanto Hariyanto. "HUBUNGAN TINGKAT STRES DENGAN KEJADIAN SINDROMA DISPESPSIA PADA ANAK USIA 10-14 TAHUN DI WILAYAH KERJA PUSKESMAS BLUTO." WIRARAJA MEDIKA 8, no. 2 (November 30, 2018): 22–28. http://dx.doi.org/10.24929/fik.v8i2.648.
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Syndrome dyspepsia often occurred and still be health problems in the society. The prevalence of cases of occurrence of symptoms syndrome dyspepsia in Western countries is around 23%-41% and in Indonesia the case of syndrome dyspepsia that came for medical to health services about 30%-60%. The cause of the symptoms of the syndrome dyspepsia is afactor of stress.
This research purposed to know the relation of stress level with incident syndrome dyspepsia. The research was carried out on children ages 10-14 years in the working area Bluto Puskesmas. This research use analytic correlative study design with crosssectional approach (α = 0,05). The respondents in this study amounted to 47 people who are taked by using simple random sampling. The instruments used are questionnaire DASS 42 to measure the stress levels and Form Check List to measure incidence syndrome dyspepsia. Data analysis using the Coefficient Contingency Test to find out the relation between the two variables.
The results showed no relationship stress levels with occurrence syndrome dyspepsiain children age 10-14 years who are in the working area Bluto Puskesmas (p = 0.327.r = 0.213). Many levels of stress occurs is mild stress level while the symptoms of the syndrome dyspepsia are most dominant is heartburn when hungry.
The factors that caused the syndrom dyspepsia in children not just because factor of stress, but several the other factors also affect happen syndrome dyspepsia like an increase in the secretion of gastric acid, Helicobacter pylori infection, Dismotitilitas gastrointestinal stimulation threshold of perception, autonomic Dysfunction, the activity of the gastric mioelektrik, the role of Diet, hormonal and environmental factors, psychological, and genetic factors. Need to be researched again the other factors that might relate to or be the cause of the syndrome dyspepsia in children ages 10-14 years in the working area Bluto Puskesmas.
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Dore, Maria Pina, Giovanni Mario Pes, Gabrio Bassotti, and Paolo Usai-Satta. "Dyspepsia: When and How to Test forHelicobacter pyloriInfection." Gastroenterology Research and Practice 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8463614.
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Dyspepsia is defined as symptoms related to the upper gastrointestinal tract. Approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to ROME III criteria. In order to avoid invasive procedures and adverse effects, to minimize costs, to speed up diagnosis, and to provide the most appropriate treatments, primary care physicians need to recognize functional dyspepsia. Because symptoms do not reliably discriminate between organic and functional forms of the disease, anamnesis, family history of peptic ulcer and/or of gastric cancer, medication history, especially for nonsteroidal anti-inflammatory drugs, age, and physical examination could help the physician in discerning between functional dyspepsia and organic causes. For patients without alarm symptoms, noninvasive testing forH. pylori, with either carbon-13-labeled urea breath testing or stool antigen testing, is recommended as a first-line strategy. In this review, we provide recommendations to guide primary care physicians for appropriate use of diagnostic tests and forH. pylorimanagement in dyspeptic patients.
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De Assis Carvalho, Mary, Gabriela Nascimento Hercos Nascimento Hercos, Renato Guilherme Corrêa Silva, and Nilton Carlos Machado. "Children Dyspepsia Symptoms Questionnaire Discriminates Dyspeptic versus Non-Dyspeptic and Organic versus Functional Dyspepsia in Children and Adolescents with Chronic Abdominal Pain." European Journal of Medical and Health Sciences 4, no. 5 (October 13, 2022): 70–76. http://dx.doi.org/10.24018/ejmed.2022.4.5.1392.
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Background: Chronic Abdominal Pain (CAP) is common in children/adolescents, and Dyspepsia is a symptom complex. Their investigation represents a significant burden and a great deal regarding the initial work-up. Consequently, scoring based on clinical symptoms and patients' characteristics comparing organic and functional Dyspepsia would be valuable in assessing CAP. Objective: To develop and validate a dyspepsia symptoms questionnaire to identify patients with Dyspepsia and discriminate between functional and organic subtypes. Methods: A single-centre, observational, prospective cohort study in a convenience sample of consecutive cases of children/adolescents for CAP. Inclusion criteria: age of 5- 17 years; CAP according to Apley and von Baeyer & Walker criteria; uninvestigated Dyspepsia. Exclusion criteria: genetic, neurological and mental disorders, history of gastrointestinal surgery, active gastrointestinal bleeding, and inflammatory bowel disease. The Questionnaire was developed in four steps: Step 1. Generation of terms. Step 2. Construct the Preliminary Questionnaire. Step 3. A pilot survey confirmed that the Questionnaire was comprehensible. Step 4. The final Children Dyspepsia Symptoms Questionnaire (CDSQ) was based on a Cronbach's alpha coefficient of 0.74. Detailed Clinical protocols for CAP, Alarm signs, and CDSQ were applied at the inclusion visit. The pain was determined using a Pain Faces Scale, and Pain Intensity was obtained. Results: The study was performed on 338 patients, with no difference in baseline characteristics between Dyspepsia and Non-dyspepsia. The comparisons of CDSQ items between Dyspepsia and Non-dyspepsia reach higher values for Dyspepsia in epigastric pain, retrosternal pyrosis, concomitant epigastric pain and retrosternal pyrosis, belching, early satiety, nausea, and postprandial fullness. The comparisons of CDSQ items between Organic and Functional groups reach higher values for Organic Dyspepsia in retrosternal pyrosis, concomitant epigastric pain and retrosternal pyrosis, nausea and belching. Alarm signs were higher for Organic Dyspepsia, except for unintentional weight loss. There was a positive and statistically significant correlation between the CDSQ score and its eight items' components for the Dyspepsia and the Non-Dyspepsia group. No effect of age of patients, sex, and duration of symptoms was found for CDSQ. Conclusion: The CDSQ is a brief questionnaire, cost-effective and well suited for uninvestigated Dyspepsia. Patients reported significantly more severe symptoms in Dyspepsia than Non-Dyspepsia. Thus, the primary application of this discriminative instrument is case-finding in epidemiological surveys and clinical trials. Assumed that the CDSQ differentiating organic from functional Dyspepsia would help manage unnecessary endoscopy procedures, compared with a strategy that would entail prompt endoscopy for all patients.
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Hasan, M. "Dyspepsia in primary care practice in Bangladesh." Bangladesh Medical Journal 42, no. 2 (May 26, 2014): 63–69. http://dx.doi.org/10.3329/bmj.v42i2.18989.
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Dyspepsia generally refers to pain or discomfort in epigastric region. It is a common problem in the community and clinical practice. It affects quality of life, productivity and causes significant resources utilization. There are a number of different causes of dyspepsia which varies from country to country. But the commonest cause in all the countries is functional dyspepsia. Investigations needed to diagnose the cause of dyspepsia are many and treatment options also vary. Consequently different scientific bodies have issued guidelines regarding the management strategy of this common disorder. But the strategy should depend on local prevalence of Helicobactor pylori infection, available health care resources and underlying serious diseases. Most dyspeptic patients are managed by primary care physicians. In Bangladesh, investigation facilities are lacking in most parts of the country. Furthermore, eradication rate of H. pylori is low and recurrence rate is high. In this article, we have reviewed the current evidences and recommendations on evaluation and treatment of dyspepsia and discussed the preferred option in primary care settings in Bangladesh. DOI: http://dx.doi.org/10.3329/bmj.v42i2.18989 Bangladesh Med J. 2013 May; 42 (2): 63-69
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Gadahire, Minakshi, Ashwin Pai, and Mohan Joshi. "Gastroscopic evaluation of patients with dyspeptic symptoms with incidental finding of cholelithiasis." International Surgery Journal 4, no. 2 (January 25, 2017): 677. http://dx.doi.org/10.18203/2349-2902.isj20170212.
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Background: Patients with dyspeptic symptoms are subjected to ultra-sonography by many practitioners and post for Cholecystectomy, if there is a finding of cholelithiasis. Many of these patients continue to have post operatively similar pain which they experienced before the cholecystectomy surgery. This made us think of doing upper gastrointestinal endoscopy to find any upper gastrointestinal disease in oesophagus, stomach or duodenum. So that if we get any positive endoscopic finding we can treat those conditions before posting the patients for cholecystectomy. Aim of the study was to study outcome of upper gastrointestinal endoscopy in patient with dyspeptic symptoms having gall stones, to evaluate whether there is any other cause of dyspepsia apart from cholelithiasis.Methods: This study was conducted at a single teaching hospital in Mumbai over a period of 3 years. Prospectively, 60 patients were studied for upper endoscopy findings associated with dyspepsia in a patient of cholelithiasis.Results: Abnormal findings of upper gastrointestinal findings on endoscopy were seen in 65% of patients.Conclusions: All Patients with dyspepsia should undergo upper gastrointestinal endoscopy before subjecting to any other radiological investigations.
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Shakya, YM. "Association of moderate level of anxiety in functional dyspeptic patients attending out door general practice in teaching hospital Kathmandu." Journal of Institute of Medicine Nepal 36, no. 2 (August 31, 2014): 76–81. http://dx.doi.org/10.59779/jiomnepal.636.
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Introduction: Functional dyspepsia (FD) is a clinical syndrome defined by chronic or recurrent upper abdominal symptom without identifiable cause by conventional diagnostic means. Hamilton Anxiety Rating Scale (HAM-A) is used to measure the severity of anxiety symptoms with mild, moderate & severe score. Only moderate level of anxiety (HAM-A) was responsible for functional dyspepsia. As age increases, chance of anxiety induced dyspepsia was also increased. This study was conducted to determine the prevalence of moderate anxiety induced dyspepsia patients presented to General Practice OPD, TUTH among 15-39 years age. Methods: 100 patients aged 15-39 years with relapse of dyspeptic symptom within 2 weeks after 6 weeks' treatment with proton pump inhibitor (PPI) correlated with moderate level of Hamilton Anxiety Rating Scale (HAM-A) who presented to GP OPD, TUTH were taken for study. Other causes of dyspepsia were excluded before enrolling them for the study. All of them underwent blood test for Helicobacter Pylori IgG serology, HAM-A scale of 18-24 score took as moderate anxiety which required treatment by TCA & PPI. Rest patient score of less than 18 were managed with PPI and above 24 score were referred to psychiatrist. Similarly duration of epigastric pain, sex & age of patients were also considered for analysis. Results: Among 100 patients, 31 of them were positive for moderate anxiety (HAM-A). 27.27% male and 33.93% female had moderate level of anxiety. Though P value was not significant, there was moderate anxiety level with functional dyspepsia associated with increasing age. Duration of epigastric pain was not significantly associated with moderate anxiety. Conclusion: Functional dyspepsia is common problem in Nepalese population, causing difficulties in their day to day life. Moderate level of anxiety (HAM-A) should be considered in management of functional dyspepsia in those with relapse of dyspepsia after discontinuation of PPL. Moderate anxiety with dyspepsia was associated with increasing age and in female gender.
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Khalid, Muhammad Ali, Jawaid Iqbal, Hassan Liaquat Memon, Farina M. Hanif, Muhammad Osama Tariq Butt, Nasir Hassan Luck, and Zain Majid. "Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center." Journal of Translational Internal Medicine 6, no. 2 (June 26, 2018): 78–81. http://dx.doi.org/10.2478/jtim-2018-0013.
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Abstract Background and Objectives Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire. Methods All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia. Mean and standard deviation were calculated for age, body mass index (BMI), disease duration and number of hemodialysis sessions. Independent t-test and Chi square tests were used for statistical analysis. Results Total number of patients was 200, out which 118 (59.3%) were male. The mean age was of 41.4 years. According to the Leeds questionnaire, dyspepsia was present in 62 (63.9%) patients. Younger patients (age 20–40 years) more frequently had dyspeptic symptoms (61.5% patients), retrosternal pain (156 patients, 78.0%), regurgitation (127 patients, 63.5%), dysphagia (67 patients, 33.5%), and nausea (142 patients, 71.0%). Patients presented with intermittent pattern of symptoms in 179 (89.5%) cases, while continuous symptoms in 6 (3.0%). Dyspepsia was associated with aspartate aminotransferase (AST) levels > 25 U/L (P = 0.001), alanine aminotransferase (ALT) levels > 28U/L (P = 0.000) and gamma glutamyl transferase (GGT) levels > 34 U/L (P = 0.002). On multivariate analysis, urea, creatinine, and presenting symptoms of dysphagia and belching showed significant statistical association with dyspepsia. Conclusion Dyspepsia is a common problem affecting patients with end stage renal disease and is associated with raised serum AST, ALT and GGT in such patients.
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Sharma, Brij, Tenzin Norbu, Rajesh Sharma, Vishal Bodh, Ashish Chauhan, Anshul Bhateja, and Dikshant Sharma. "Etiological Profile of Dyspepsia in Difficult-to-reach Tribal Population of Himachal Pradesh." CHRISMED Journal of Health and Research 10, no. 4 (October 2023): 324–28. http://dx.doi.org/10.4103/cjhr.cjhr_43_23.
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Abstract Background: Dyspepsia exhibits a diverse range of underlying causes, with functional dyspepsia (FD) surpassing organic etiologies in prevalence. However, there exists a noticeable absence of prior research delineating the etiological spectrum of dyspepsia among the tribal regions of Himachal Pradesh (HP). The present study was carried out to determine the etiological profile of dyspepsia within this specific population. Materials and Methods: Conducted as a cross-sectional observational study centered around an endoscopy health camp, this investigation took place at the community health center in Kaza – a pivotal administrative hub in the remote Spiti Valley of the Lahaul and Spiti tribal district in HP. The study encompassed consecutive patients above 18 years of age presenting with gastrointestinal complaints. Those predominantly reporting dyspepsia were selected and subsequently underwent thorough endoscopic examination. Data analysis incorporated factors such as age, gender, history of smoking, alcohol consumption, nonsteroidal anti-inflammatory drug usage, and endoscopic findings. Results: Encompassing a total of 187 patients with an average age of 48.5 ± 13.4, the study found that endoscopy yielded normal results in 59.9% of cases (categorized as FD), whereas 40.1% displayed abnormal findings (categorized as organic dyspepsia). Among the latter, the most prevalent organic lesions were peptic ulcer disease (PUD) (62.7%) and erosive esophagitis (22.7%). Furthermore, gastric malignancy was detected in 4% of the cases. Conclusion: The primary organic causes of dyspepsia within the tribal areas of HP appear to be dominated by PUDs, closely followed by erosive esophagitis. Gastric malignancy, although less frequent, was identified in approximately 4% of the dyspeptic cases studied.
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Marković, Marija, Mladen Maksić, Jelena Živić, Nebojša Igrutinović, Željko Todorović, and Nataša Zdravković. "Dominant symptomatology and clinically significant endoscopic findings in patients with dyspepsia." Acta Facultatis Medicae Naissensis 40, no. 3 (2023): 292–98. http://dx.doi.org/10.5937/afmnai40-39533.
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Introduction. The role of esophagogastroduodenoscopy (EGDS) is reflected in the evaluation of various symptoms and signs of numerous organic disorders such as ulcer disease, reflux disease, diverticula, achalasia and tumors of the upper gastrointestinal tract, but also in the exclusion of the same conditions in patients, the basis of which is a functional disorder. Functional diseases of the digestive system are a great challenge in everyday clinical work. Aim. The goal of this study was to determine the frequency of functional dyspepsia in relation to the organic one by sex and age as well as the frequency of Helicobacter pylori infection (HBP) in patients with dyspepsia, performing upper endoscopy as the gold standard in differential diagnosis. Methods. The study analyzed 5,200 patients over a four-year period. All patients underwent upper endoscopy with dyspeptic disorders and all subjects underwent the biopsy of the gastric mucosa and pathohistological verification. Results. The frequency of dyspeptic disorders was higher in women than in men, with the average age being 43 years. The most common complaints were epigastric pain and postprandial fullness. Endoscopic findings were positive in 55% of patients, predominantly over 55 years of age, with no statistical difference between the HBP status. The most common changes were reflux esophagitis, gastric ulcer and duodenal ulcer. Conclusion. Our study showed a high rate of positive endoscopic findings in patients with dyspepsia according to the criteria of Rome IV. Gastroscopy has significant implications in patients with dyspepsia.
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Akbar, Hairil. "Pola Makan Mempengaruhi Kejadian Sindrom Dispepsia pada Mahasiswa STIKES Graha Medika Kotamobagu." KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat 6, no. 1 (July 10, 2020): 14–21. http://dx.doi.org/10.24903/kujkm.v6i1.857.
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Background:
Dyspepsia is a set of symptoms in the form of complaints of pain, a feeling of persistent or episodic discomfort in upper stomach accompanied by complaints such as feeling full when eating, satiety, heartburn, bloating, belching, anorexia, nausea, and vomiting. Dyspepsia is one type non contagious disease that occurs not only in Indonesia, but also in the world. Globally there are about 15-40% of the population is dyspepsia sufferers. Every year this complaint concerns 25% of the world's population. In Asia the prevalence of dyspepsia ranges from 8-30%.
Objectives:
The purpose of this study was to analyze the relationship between eating patterns and the incidence of dyspeptic syndrome in the students of Graha Medika College of Health Sciences, Kotamobagu.
Research Metodes:
This study applied observational analytic study with cross sectional study approach. The population was all active students of Graha Medika College of Health Sciences, as many as 885 with a total sample of 151 respondents. The sampling technique used was simple random sampling. Data were collected by direct interviews with respondents using a questionnaire and analyzed univariately and bivariately using the chi square test.
Results:
Statistical test results indicated that there was a relationship between eating patterns (p = 0.006) to the incidence of dyspepsia syndrome in students of Graha Medika College of Health Sciences.
Conclusion:
There was a relationship between eating pattern and dyspepsia syndrome.
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Huang, Chung-Tsui, Tzong-Hsi Lee, Cheng-Kuan Lin, Chao-Yi Chen, Yi-Feng Yang, and Yao-Jen Liang. "Pancreatic Fibrosis (Early Chronic Pancreatitis) as Emerging Diagnosis in Structural Causes of Dyspepsia: Evidence from Endoscopic Ultrasonography and Shear Wave Elastography." Diagnostics 11, no. 7 (July 13, 2021): 1252. http://dx.doi.org/10.3390/diagnostics11071252.
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A new concept for the diagnosis and management of non-functional dyspepsia in guidelines was lacking in the past decade. Medical advancement has proven pancreatic fibrosis (essential image evidence of early chronic pancreatitis) to be a cause of dyspepsia and related to pancreatic exocrine dysfunction. This study aimed to analyze the clinical picture, biomarker, and percentage of pancreatic fibrosis in the dyspeptic population. A total of 141 consecutive patients were retrospectively enrolled. They were diagnosed with peptic ulcer disease, 9.2% (n = 13); pancreatic fibrosis, 17% (n = 24); pure Helicobacter pylori infection, 19.9% (n = 28); functional dyspepsia, 53.2% (n = 75); and chronic pancreatitis, 0.7% (n = 1). Among those with pancreatic fibrosis, (n = 24), 11 were diagnosed on the basis of a pancreatic acoustic radiation force impulse exceeding 1.4 m/s, and the remaining 13 were diagnosed with early chronic pancreatitis with at least three of the Japanese endoscopic ultrasonography criteria. The anatomic distribution of parenchymal criteria of early chronic pancreatitis was head, 53%; body, 38%; and tail, 9%. There were 17 cases (71%, 17/24) without Helicobacter pylori and whose dyspepsia improved after pancreatic enzyme replacement with a ratio of 82.3% (14/17). Of the 141 cases, 19 received gastric emptying scintigraphy and Western blot analysis of chromogranin-A in duodenal mucosa. Delayed gastric emptying was more common in functional dyspepsia and chromogranin-A was expressed more in pancreatic fibrosis. In conclusion, pancreatic fibrosis (including early chronic pancreatitis) outnumbered peptic ulcer disease in the dyspeptic population and pancreatic enzyme therapy was effective for 82% of cases. In early chronic pancreatitis, pancreatic fibrosis is dominant in the head location, and duodenum mucosa chromogranin-A is a potential biomarker with increased expression in an age-matched manner.
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Ji, Ting, Xueliang Li, Lin Lin, Liuqin Jiang, Meifeng Wang, Xiaopin Zhou, Ranran Zhang, and Jiande DZ Chen. "An Alternative to Current Therapies of Functional Dyspepsia: Self-Administrated Transcutaneous Electroacupuncture Improves Dyspeptic Symptoms." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/832523.
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Functional dyspepsia is of high prevalence with little treatment options. The aim of this study was to develop a new treatment method using self-management transcutaneous electroacupuncture (TEA) for functional dyspepsia (FD). Twenty-eight patients with FD were enrolled and underwent a crossover clinical trial with 2-week TEA at ST36 and PC6 and 2-week sham-TEA at nonacupuncture sham-points. Questionnaires were used to assess symptoms of dyspepsia and quality of life. Physiological testing included gastric emptying and electrogastrography. It was found that (1) TEA but not sham-TEA significantly improved dyspeptic symptoms and 4 domains in quality of life; improvement was also noted in self-rated anxiety and depression scores; (2) gastric emptying was significantly and substantially increased with 2-week TEA but not sham-TEA; and (3) gastric accommodation was also improved with TEA but not sham-TEA, reflected as increased ingested nutrient volumes at the levels of satiety and maximum tolerance. These findings suggest a therapeutic potential of self-administrated TEA method for functional dyspepsia, possibly attributed to improvement in gastric motility.
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Andaleeb, Hina, Anum x. Anum Umar, Anwar Hussain Abbasi, Aleena Shahid, Khawaja Ashfaq Ahmed, and Nadeem Yousuf. "Evaluation of Significant Endoscopic Findings Using Alarm Features of Dyspepsia in Patients Visiting Gastroenterology Department at RIHS Islamabad." Pakistan Journal of Medical and Health Sciences 16, no. 5 (May 30, 2022): 1365–67. http://dx.doi.org/10.53350/pjmhs221651365.
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Objective: The aim of this study is to analyze significant findings of upper gastrointestinal endoscopy in patients having alarming features of dyspepsia. Study Design: Retrospective study Methodology: This retrospective study was conducted in the Gastroenterology Department at RIHS Islamabad from March 2021 to March 2022 and included adult patients presenting with alarm features and were referred for gastroscopy for dyspepsia. Those ageing below 18 years were excluded. The information including demographic data, referral for the procedure, endoscopic findings and present alarm features and dyspeptic symptoms was recorded. The diagnosis was made on the basis of visual examination. Results: A total of 140 patients who underwent gastroscopic procedures were included in the study. Most of the subjects (74.1%) reported epigastric burning, 10.8% complained of heartburn, 10.8% of regurgitation and 8% reported globus. Few of the participants reported symptoms such as bloating (5.3%), burping (5.3%), abdominal fullness (3.8%), chest pain (3.8%) and early satiety (0.8%). No significant relation was observed between warning signs and findings from the endoscopy. Conclusion: Dyspeptic patients showing alarming signs such as vomiting, dysphagia and upper gastrointestinal bleeding must be prescribed immediate endoscopy. Keywords: Dyspepsia, gastroenterology, endoscopic findings, epigastric burning
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Paroni Sterbini, Francesco, Alessandra Palladini, Luca Masucci, Carlo Vittorio Cannistraci, Roberta Pastorino, Gianluca Ianiro, Francesca Bugli, et al. "Effects of Proton Pump Inhibitors on the Gastric Mucosa-Associated Microbiota in Dyspeptic Patients." Applied and Environmental Microbiology 82, no. 22 (September 2, 2016): 6633–44. http://dx.doi.org/10.1128/aem.01437-16.
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ABSTRACTBesides being part of anti-Helicobacter pyloritreatment regimens, proton pump inhibitors (PPIs) are increasingly being used to treat dyspepsia. However, little is known about the effects of PPIs on the human gastric microbiota, especially those related toH. pyloriinfection. The goal of this study was to characterize the stomach microbial communities in patients with dyspepsia and to investigate their relationships with PPI use andH. pyloristatus. Using 16S rRNA gene pyrosequencing, we analyzed the mucosa-associated microbial populations of 24 patients, of whom 12 were treated with the PPI omeprazole and 9 (5 treated and 4 untreated) were positive forH. pyloriinfection. TheProteobacteria,Firmicutes,Bacteroidetes,Fusobacteria, andActinobacteriaphyla accounted for 98% of all of the sequences, withHelicobacter,Streptococcus, andPrevotellaranking among the 10 most abundant genera.H. pyloriinfection or PPI treatment did not significantly influence gastric microbial species composition in dyspeptic patients. Principal-coordinate analysis of weighted UniFrac distances in these communities revealed clear but significant separation according toH. pyloristatus only. However, in PPI-treated patients,Firmicutes, particularlyStreptococcaceae, were significantly increased in relative abundance compared to those in untreated patients. Consistently,Streptococcuswas also found to significantly increase in relation to PPI treatment, and this increase seemed to occur independently ofH. pyloriinfection. Our results suggest thatStreptococcusmay be a key indicator of PPI-induced gastric microbial composition changes in dyspeptic patients. Whether the gastric microbiota alteration contributes to dyspepsia needs further investigation.IMPORTANCEAlthough PPIs have become a popular treatment choice, a growing number of dyspeptic patients may be treated unnecessarily. We found that patients treated with omeprazole showed gastric microbial communities that were different from those of untreated patients. These differences regarded the abundances of specific taxa. By understanding the relationships between PPIs and members of the gastric microbiota, it will be possible to envisage new strategies for better managing patients with dyspepsia.
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Bayupurnama, Putut, Noor Asyiqah Sofia, and Angelin Utami Cahyani. "Interaction between Internet Browsing Habit and Dyspepsia Syndrome in Adolescent." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 23, no. 1 (May 15, 2022): 38–42. http://dx.doi.org/10.24871/231202238-42.
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Background: There were many patients, including adolescent, with dyspepsia symptoms in our daily clinical practice have been interacting with internet search engine to find medical information which induced or worsened their dyspeptic symptoms. Aim of the study is to know the pattern of internet browsing habit and dyspepsia syndrome in adolescentMethod: Grade 12 level students of senior high schools in Yogyakarta, Indonesia were included in the study with stratified random sampling method. Students with confirmed organic dyspepsia diagnosis were excluded. We use two simple questions to reveal the students internet browsing habit, question no 1 :“Did you ever browse information about diseases in the internet?” (answer choice: a.never;b.once;c.more than once); question no 2.: “Did you ever browse information about your medical complaint in the internet?” (answer choice: a.never;b.once;c.more than once). We used validated Gastrointestinal Symptom score (GIS) to reveal the students dyspepsia symptoms. Data were analyzed with chi-square test and anova.Results: There were 665 (477 girls and 188 boys) senior high school students (age range : 16-20 years old) included in this study. Based on question no 1, the result showed significantly different (p 0.001) between students with and without the dyspepsia syndrome, and the question no 2 also showed similar result (p=0.002). The anova between GIS and question no 1 showed significantly different ( p0.001) and the similar result was also found between GIS and question no 2 (p0.001). Conclusion:The internet browsing habit may influence the development of dyspepsia syndrome in adolescent and further study is needed to find the cause and effect relationship.
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Hasanah, Nur, Lela kania Rahsa Puji, Silvester Maximus TulandI, Fadly Putrajaya, and Indah Kusmana. "PROFIL DAN KARAKTERISTIK KLINIS PENGGUNAAN OBAT DISPEPSIA." E-Jurnal Medika Udayana 11, no. 12 (December 21, 2022): 79. http://dx.doi.org/10.24843/mu.2022.v11.i12.p14.
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Dyspepsia is a syndrome with upper gastrointestinal pain, flatulence, epigastric/heartburn pain, early satiety, nausea, and vomiting. This study aims to determine the profile and characteristics of the use of dyspeptic drugs at Icon 8 BSD Clinic in 2021 based on age, gender, education, occupation, clinical manifestations, drug class, and variations for antiulcer medicines, dosage forms, and drug administration routes. This study is a descriptive study with a retrospective data evaluation; the data obtained from the medical records of dyspeptic patients using the probability sampling method is then presented as percentages and tables. The results showed that dyspepsia patients were dominated by the age range of 26-45 years (43.2%), female gender (51.9%), college education (41.4%), and having a job as an employee (33.3%). The most common clinical characteristic of dyspeptic patients was nausea (72.2%). Based on the H2 antagonist drug class, ranitidine (20.4%), with a combination of 2 antiulcer drugs, namely omeprazole and ranitidine (15.4%), tablet dosage form (70.9%) and oral route of administration (96.6% ).
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Chiba, N., ABR Thomson, and P. Sinclair. "From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons withHelicobacter pyloriAssociated Diseases." Canadian Journal of Gastroenterology 14, no. 3 (2000): 188–98. http://dx.doi.org/10.1155/2000/578059.
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In-depth meetings of the XIth International Workshop on Gastroduodenal Pathology andHelicobacter pyloriled to the presentation and discussion of extensive new data onH pyloriand its diseases. The mode of transmission ofH pyloriremains unclear, and it remains unknown why only a small proportion of infected individuals develop duodenal or gastric ulcer disease and even fewer develop gastric cancer. The role ofH pylorieradication in persons with uninvestigated dyspepsia remains controversial. New clinical trials ofH pyloritreatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. Clearly the move is toward symptom-based management of persons with dyspepsia, with fewer endoscopies being needed in the otherwise healthy young dyspeptic patients. It remains controversial whether eradicatingH pyloriin duodenal ulcer or functional dyspepsia increases the risk of subsequent development of gastroesophageal reflux disease. The one-week proton pump inhibitor-based triple regimens remain the gold standard ofH pyloritherapy, but some of the ranitidine bismuth citrate plus two antibiotic regimens also achieve an 80%H pylorieradication rate on an intention-to-treat basis. While the urea breath test remains the noninvasive test of choice, interesting new data are available on the use of stool antigen testing to diagnoseH pyloriinfection. The number ofH pylori-associated gastroduodenal diseases grows to include possible liver, vascular, immune and skin conditions.
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ALMEIDA, Alessandra Maciel, Luísa Alvarenga Guerra MARTINS, Patrícia Liz Terenzi CUNHA, Viviane Willig BRASIL, Lucas Galuppo Fernandes FÉLIX, and Maria do Carmo Friche PASSOS. "Prevalence of dyspeptic symptoms and heartburn of adults in Belo Horizonte, Brazil." Arquivos de Gastroenterologia 54, no. 1 (March 2017): 46–50. http://dx.doi.org/10.1590/s0004-2803.2017v54n1-09.
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ABSTRACT BACKGROUND Medical literature has shown dyspepsia and heartburn-related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. OBJECTIVE Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. METHODS Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social-demographic characteristics, eating habits, digestive symptoms, medical appointments, medications, exams, previous surgeries and comorbidities was applied. A questionnaire about functional dyspepsia diagnosis (Rome III) was also applied. RESULTS A total of 548 individuals were interviewed. Among these, 58.4% were women, 59.3% were white, 55.9% were single and the average age was 36 years. Within this group, 376 individuals (68.6%) declared to have some symptom and/or use medication to relieve dyspepsia symptoms, and for these patients were applied the Rome III questionnaire. Based on the diagnostic criteria for the questionnaire proposed by the Rome III consensus, the symptom of postprandial fullness was reported by 6.7% of the individuals, early satiety (3.5%) and epigastric pain (10.6%). The overlap of these symptoms was very frequent. The prevalence of functional dyspepsia was 10.6% (postprandial discomfort syndrome (8.2%) and epigastric pain syndrome (2.4%). Among all participants, 52.5% reported heartburn, and 11.1% presented this symptom at least once a week. The most used drug was omeprazole. CONCLUSION The prevalence of dyspeptic symptoms and heartburn among a Brazilian adult urban population is similar to those described in other countries.