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Dissertations / Theses on the topic 'Dynein'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Malkova, Barbora. "Structural studies of cytoplasmic dynein." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540206.

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2

Liu, Siming. "TESTING THE MULTI-DYNEIN HYPOTHESIS BY MUTATING INNER ARM DYNEIN HEAVY CHAINS IN TETRAHYMENA THERMOPHILA." Miami University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1077152822.

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3

Villemant, Cecile Madeleine. "Investigating dynein light intermediate chains function." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518455.

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4

Kardon, Julia R. "Regulation of the cytoplasmic dynein motor." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359552.

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5

Gleave, Emma Sarah. "Structural and single-molecule studies of the cytoplasmic dynein motor domain." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708182.

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6

Diamant, Aristides G. "The structure of the cytoplasmic dynein tail." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/249014.

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Cytoplasmic dynein is a molecular motor that moves cargos along microtubules. Dynein, together with its large co-factor dynactin, is responsible for the vast majority of traffic towards the centre of the cell. The largest subunit of the dynein complex is called the dynein heavy chain (DHC). The DHC includes a C-terminal motor domain, which converts ATP hydrolysis into mechanical force, an N-terminal tail domain, and a flexible linker domain to join the two together. An intermediate chain (DIC) and light intermediate chain (DLIC) bind directly to the DHC tail, while light chains (DLCs) bind to
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7

Roberts, Anthony John. "Structural studies on the mechanism of dynein." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511146.

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8

Lo, Wai Hong. "Biochemical, structural and functional characterization of the light chains of the microtubule-based motor dynein /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20LO.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 133-154). Also available in electronic version. Access restricted to campus users.
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9

Nyarko, Afua A. "Structure and interactions of subunits of cytoplasmic dynein /." View abstract, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3191709.

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10

Nettesheim, Guilherme, Rafael A. Longoria, Allyson M. Rice, and George T. Shubeita. "Kinesin and dynein respond differently to cytoplasmic drag." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-182714.

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11

Milisav-Ribaric, Irina. "Characterisation of human dynein-related genes from testis." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627168.

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12

Nettesheim, Guilherme, Rafael A. Longoria, Allyson M. Rice, and George T. Shubeita. "Kinesin and dynein respond differently to cytoplasmic drag." Diffusion fundamentals 20 (2013) 37, S. 1, 2013. https://ul.qucosa.de/id/qucosa%3A13605.

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13

Paschal, Bryce M. "Structure and Function of Cytoplasmic Dynein: a Thesis." eScholarship@UMMS, 1992. https://escholarship.umassmed.edu/gsbs_diss/82.

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In previous work I described the purification and properties of the microtubule-based mechanochemical ATPase cytoplasmic dynein. Cytoplasmic dynein was found to produce force along microtubules in the direction corresponding to retrograde axonal transport. Cytoplasmic dynein has been identified in a variety of eukaryotes including yeast and human, and there is a growing body of evidence suggesting that this "molecular motor" is responsible for the transport of membranous organelles and mitotic chromosomes. The first part of this thesis investigates the molecular basis of microtubule-activation
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14

Roger, Yvonne. "The cytoplasmic dynein motor complex at microtubule plus-ends and in long range motility of early endosomes, microtubule plus-end anchorage and processivity of cytoplasmic dynein." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/11022.

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Cytoplasmic dynein is a microtubule-dependent motor protein which participates in numerous cellular processes. The motor complex consists of two heavy chains, intermediate, light intermediate and 3 families of light chains. Dynein is able to bind to these accessory chains as well as to regulatory proteins which enables the motor protein to fulfil such a variety of cellular processes. The associated light chains participate in long-distance organelle and vesicle transport in interphase and in chromosome segregation during mitosis. However, how these light chains control the activity of the moto
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15

Ananthanarayanan, Vaishnavi. "Dynein dynamics during meiotic nuclear oscillations of fission yeast." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135620.

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Cytoplasmic dynein is a ubiquitous minus-end directed motor protein that is essential for a variety of cellular processes ranging from cargo transport to spindle and chromosome positioning. Specifically, in fission yeast during meiotic prophase, the fused nucleus follows the spindle pole body in oscillatory movements from one cell pole to the other. The three molecular players that are essential to this process are: (i) the motor protein dynein, which powers the movement of the nucleus, (ii) microtubules, which provide the tracts for the movement and (iii) Num1, the anchor protein of dynein at
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16

Tolic-Nørrelykke, Iva M., Sven K. Vogel, Nenad Pavin, Nicola Maghelli, and Frank Jülicher. "Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-180717.

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Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing mic
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17

Tolic-Nørrelykke, Iva M., Sven K. Vogel, Nenad Pavin, Nicola Maghelli, and Frank Jülicher. "Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations." PLOS, 2009. https://tud.qucosa.de/id/qucosa%3A28924.

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Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing mic
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18

Kinzel, Kathryn Whitney. "Functional analysis of inner-arm dynein knockdowns in Trypanosoma brucei /." Connect to online version, 2008. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2008/268.pdf.

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19

Belanger-Nelson, Erika. "The regulation of orexin receptor function by dynein light chains." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96954.

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Orexins (OX-A, OX-B) are involved in the regulation of sleep, feeding and reward. The action of these peptides is governed by Orexin Receptors 1 and 2 (OX1R, OX2R). In aim to understand the mechanisms involved upon activation of these receptors, we have identified the dynein light chains 1 and 3 (Dynlt1/3) as novel partners. We hypothesize that Dynlt1/3 are important for orexin receptor intracellular regulation. After identification of a strong interaction between OX1R and Dynlt1 and the importance of the OX1R C-terminal domain residues, the functional implication of this novel interaction was
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20

Redwine, William Bret. "The Structural Basis for Microtubule Binding and Release by Dynein." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10667.

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Eukaryotic cells face a considerable challenge organizing a complicated interior with spatial and temporal precision. They do so, in part, through the deployment of the microtubule- based molecular motors kinesin and dynein, which translate chemo-mechanical force production into the movement of diverse cargo. Many aspects of kinesin’s motility mechanism are now known in detail, whereas fundamental aspects of dynein’s motility mechanism remain unclear. An important unresolved question is how dynein couples rounds of ATP binding and hydrolysis to changes in affinity for its track, a requisite fo
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21

Trott, Laurie Elizabeth. "A physical model describing the transport mechanisms of cytoplasmic dynein." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/66461/.

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Cytoplasmic dynein 1 is crucial for many cellular processes including endocytosis and cell division. Dynein malfunction can lead to neurodevelopmental and neurodegenerative disease, such as intellectual disability, Charcot-Marie-Tooth disease and spinal muscular atrophy with lower extremity predominance. We formulate, based on physical principles, a mechanical model to describe the stepping behaviour of cytoplasmic dynein walking on microtubules. Unlike previous studies on physical models of this nature, we base our formulation on the whole structure of dynein to include the temporal dynamics
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22

Hanson, Benjamin S. "Mesoscale modelling of cytoplasmic dynein using fluctuating finite element analysis." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/19398/.

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At the forefront of biological experimentation and simulation technology is the attempt to understand the biological mesoscale, the regime in which thermal fluctuations are still vital for function but atomic resolution may no longer be required. There is a wealth of low-resolution biomolecular structural data of macromolecules available for study, and experimental developments are allowing these biomolecules to be visualised to near-atomic resolution without the need for crystallisation. It is clear that a new form of simulation is required to take advantage of this structural data in order t
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23

Yang, Yen Ching. "The regulation of dynein function in membrane movement by NudEL." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-regulation-of-dynein-function-in-membrane-movement-by-nudel(0156ad8a-546f-4ee1-8682-d68d8c782d56).html.

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The accurate regulation of cytoplasmic dynein-1 (dynein) is very important since dynein performs multiple functions in cells. In interphase, dynein is responsible for the correct positioning of membrane organelles, such as the Golgi complex and lysosomes. Previous work suggests that dynein's accessory proteins NudEL/Nde1/LIS1¬ may be involved in regulating dynein-dependent organelle movement. This study focuses on how NudEL regulates dynein-driven membrane movement. By using various NudEL fragments, this work presents the first evidence that NudEL is involved in the regulation of dynein-driven
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24

Subramanian, Aswati. "p28 DYNEIN LIGHT CHAINS AND CILIARY MOTILITY IN Tetrahymena thermophila." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1389719903.

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25

Granger, Elizabeth. "The interplay between dynein, accessory proteins and the endocytic pathway." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-interplay-between-dynein-accessory-proteins-and-the-endocytic-pathway(c456befe-2114-41a1-90cc-e5123624a2d3).html.

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Cytoplasmic dynein 1 (dynein) is a multi-subunit complex that transports cargo along microtubules towards their minus ends. These microtubule minus ends are normally located toward the centre of the cell. Dynein is involved in transport of endocytic and autophagic membranes and is tightly regulated by interactions between dynein subunits and by dynein-accessory proteins. Dynein accessory proteins that are involved in a wide range of dynein-driven transport events include dynactin, Lis1 and the paralogues Nde1 and Ndel1. Lis1 and Nde1/Ndel1 interact with each other and are involved in the recru
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26

Zou, Sirui. "The Mechanistic Basis of Dynein Microtubule Binding and Its Regulation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226071.

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Eukaryotic cells use a diverse toolbox of cytoskeletal motors to transport and position cellular materials in space and time. Two microtubule-based motors—kinesin and dynein—transport organelles, RNA and protein cargos over long-distances. While multiple kinesin motors are used for long-distance plus- end-directed transport, a single type of dynein—cytoplasmic dynein 1— performs nearly all minus-end-directed tasks. Despite cytoplasmic dynein’s role in such diverse activities, many aspects of its molecular mechanism remain poorly understood. My thesis work uses a combination of cryo-electron mi
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27

Dunsch, Anja Katrin. "Control of the mitotic spindle by dynein light chain 1 complexes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:b2fd5670-a035-42ca-aaef-78a30aeaa084.

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Robust control mechanisms ensure faithful inheritance of an intact genome through the processes of mitosis and cytokinesis. Different populations of the cytoplasmic dynein motor defined by specific dynein adaptor complexes are required for the formation of a stable bipolar mitotic spindle. This study analysed how different dynein subcomplexes contribute to spindle formation and orientation. Various dynein subpopulations were identified by mass spectrometry. I have shown that the dynein light chain 1 (DYNLL1) directly interacts with the kinetochore localised Astrin-Kinastrin complex as well as the
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28

Hernandez-Lopez, Rogelio Antonio. "Mechanistic Studies of the Microtubule-Based Motors Dynein and Kinesin-8." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467496.

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The precise delivery and organization of intracellular factors in space and time relies on a set of molecules that move along and regulate the dynamics of cytoskeletal filaments. The two families of microtubule-based motors-- dyneins and kinesins-- power vital biological processes such as intracellular transport, chromosome segregation and more broadly cell-cell communication and cell polarization. Despite their role in such diverse activities, their molecular mechanisms remain poorly understood. Combining biochemistry, cryo-electron microscopy, molecular dynamics simulations and single molecu
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29

Colantonio, Jessica Russell. "The role of GAS11 and the dynein regulatory complex in vertebrates." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1495958921&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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30

Derr, Nathan Dickson. "Coordination of Individual and Ensemble Cytoskeletal Motors Studied Using Tools from DNA Nanotechnology." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10889.

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The cytoskeletal molecular motors kinesin-1 and cytoplasmic dynein drive many diverse functions within eukaryotic cells. They are responsible for numerous spatially and temporally dependent intracellular processes crucial for cellular activity, including cytokinesis, maintenance of sub-cellular organization and the transport of myriad cargos along microtubule tracks. Cytoplasmic dynein and kinesin-1 are processive, but opposite polarity, homodimeric motors; they each can take hundreds of thousands of consecutive steps, but do so in opposite directions along their microtubule tracks. These step
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31

Tharia, Hazel Ann. "Biochemical characterization of 14S dynein isolated from the cilia of Tetrahymena thermophila." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35168.

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Dynein is the ATPase responsible for cilia and flagella motility in eukaryotic organisms. At least two ATPases have been identified in Tetrahymena thermophila and are termed 22S and 14S on account of their differing sedimentation coefficients. 14S dynein was fractionated, using anion-exchange Fast Protein Liquid Chromatography, into four fractions (designated 1-4). Electron microscopy analysis revealed that the four fractions were structurally distinct. Fraction 1 comprised two globular heads interconnected via two stems; fraction 2 consisted of at least two clearly different globular structur
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32

Kuta, A. "Investigation of subunits of the cytoplasmic dynein complex using novel mouse models." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324544/.

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Cytoplasmic dynein is a multisubunit complex responsible for the transport of cellular components from the cell periphery towards the nucleus. The role of the dynein complex in vesicle trafficking, organelle positioning and chromosome segregation during mitosis has been extensively studied but still little is known of specific roles of distinct subunits of the complex. Cytoplasmic dynein is a dimeric complex consisting of heavy chains, intermediate chains, light intermediate chains and three light chains. In order to investigate the roles of the cytoplasmic dynein subunits, two mouse lines wit
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33

Tai, Chin-Yin. "Roles of Lissencephaly Gene, LIS1, in Regulating Cytoplasmic Dynein Functions: a Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/31.

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Spontaneous mutations in the human LIS1 gene are responsible for Type I lissencephaly ("smooth brain"). The distribution of neurons within the cerebral cortex of lissencephalic children appears randomized, probably owing to a defect in neuronal migration during early development. LIS1 has been implicated in the dynein pathway by genetic analyses in fungi. We previously reported that the vertebrate LIS1 co-localized with dynein at prometaphase kinetochores, and interference with LIS1 function at kinetochore caused misalignment of chromosomes onto the metaphase plate. This leads to a hypothesis
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34

Faulkner, Nicole E. "Mitotic Roles for Cytoplasmic Dynein and Implications for Brain Developmental Disease: a Dissertation." eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/182.

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Cytoplasmic dynein has been implicated in a wide range of functions. Originally characterized as being responsible for retrograde axonal transport, its has also been shown to traffic vesicular organelles (Golgi, endosome and lysosome distribution), transport viral particles to the nucleus, and participate in microtubule organization. During mitosis, cytoplasmic dynein is thought to function in spindle pole focusing and prometaphase kinetochore capture. This thesis explores the mitotic roles of cytoplasmic dynein. The first chapter addresses the role of cytoplasmic dynein in kinetochore activit
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35

Salter, Hannah Kate. "Molecular mechanisms underpinning Bicaudal-D's role in linking cargoes to the dynein motor." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648370.

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36

Faulkner, Nicole E. "Mitotic Roles for Cytoplasmic Dynein and Implications for Brain Developmental Disease: a Dissertation." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/182.

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Cytoplasmic dynein has been implicated in a wide range of functions. Originally characterized as being responsible for retrograde axonal transport, its has also been shown to traffic vesicular organelles (Golgi, endosome and lysosome distribution), transport viral particles to the nucleus, and participate in microtubule organization. During mitosis, cytoplasmic dynein is thought to function in spindle pole focusing and prometaphase kinetochore capture. This thesis explores the mitotic roles of cytoplasmic dynein. The first chapter addresses the role of cytoplasmic dynein in kinetochore activit
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37

Sladewski, Thomas Edward. "Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/689.

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mRNA localization ensures correct spatial and temporal control of protein synthesis in the cell. Using a single molecule in vitro approach, we provide insight into the mechanisms by which localizing mRNAs are carried by molecular motors on cytoskeletal tracks to their destination. Budding yeast serves as a model system for studying the mechanisms of mRNA transport because localizing mRNAs are moved on actin tracks in the cell by a single class V myosin motor, Myo4p. Molecular motors that specialize in cargo transport are generally double-headed so that they can "walk" for many microns without
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38

Tynan, Sharon H. "The Role of the Light Intermediate Chains in Cytoplasmic Dynein Function: a Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/85.

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Cytoplasmic dynein is a multisubunit complex involved in retrograde transport of cellular components along microtubules. The heavy chains (HC) are very large catalytic subunits which possess microtubule binding ability. The intermediate chains (IC) are responsible for targeting dynein to its appropriate cargo by interacting with the dynactin complex. The light intermediate chains (LIC) are previously unexplored subunits that have been proposed to modulate dynein activity by regulating the motor or the IC-dynactin interaction. The light chains (LC) are a newly identified class of subunit which
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39

Vernon, Geraint Grrffydd. "Mechanical activity and its propagation along the flagellar axoneme : studies using caged ATP." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319140.

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40

Mali, Girish Ram. "Multisystem functional characterisation of motile ciliopathy genes HEATR2 and ZMYND10." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21683.

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Cilia are polarized extensions of the cells microtubule-based cytoskeleton dedicated to sensory, signaling and motility-related functions. In mammals, there are two main types of cilia, immotile and motile, where motile cilia generate/modulate fluid flow at the embryonic node, in respiratory airways, cerebral ventricles and the oviduct in addition to sperm propulsion via the flagellum. Defects in cilia motility cause a rare genetic disorder called Primary Ciliary Dyskinesia (PCD). In this thesis, I present functional and molecular characterisation of two PCD causing genes HEATR2 and ZMYND10. C
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Meaders, Johnathan Lee. "Growth, Morphology, and Positioning of Microtubule Asters in Large Zygotes:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:109018.

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Thesis advisor: David R. Burgess<br>Microtubule (MT) asters are radial arrays of MTs nucleated from a microtubule organizingcenter (MTOC) such as the centrosome. Within many cell types, which display highly diverse size and shape, MT asters orchestrate spatial positioning of organelles to ensure proper cellular function throughout the cell cycle and development. Therefore, asters have adopted a wide variety of sizes and morphologies, which are directly affects how they migrate and position within the cell. In large cells, for example during embryonic development, asters growth to sizes on the
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42

Ahrens, Nikolai. "Evidence for and characterization of cytoplasmic dynein and kinesin in renal medulla and cortex." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386898.

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43

Nandini, Swaran. "Characterization of Motility Alterations Caused By the Impairment of Dynein/Dynactin Motor Protein Complex." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5824.

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Transport of intracellular cargo is an important and dynamic process required for cell maintenance and survival. Dynein is the motor protein that carries organelles and vesicles from the cell periphery to the cell center along the microtubule network. Dynactin is a protein that activates dynein for this transport process. Together, dynein and dynactin forms a motor protein complex that is essential for transport processes in all the vertebrate cells. Using fluorescent microscope based live cell imaging techniques and kymograph analyses, I studied dynein/dynactin disruptions on the intracellula
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44

Alami, Nael H. "The Role of Myosin Va and the Dynein/Dynactin Complex in Neurofilament Axonal Transport." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259091406.

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45

Wadzinski, Thomas. "Light Intermediate Chain 1: a Multifunctional Cargo Binder for Cytoplasmic Dynein 1: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/167.

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Cells as dynamic, interactive, and self contained units of life have a need for molecular motors that can create physical forces to move cargoes within the cell. Cytoplasmic dynein 1 is one such molecular motor that has many functions in the cell. The number and variety of functions that involve cytoplasmic dynein 1 suggest that there are a number of different binding sites on dynein for different proteins. Cytoplasmic dynein 1 is a multiprotein complex made up of six different subunit families. The many different combinations of subunits that could be used to make up a cytoplasmic dynein 1 ho
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46

Babic, Milos. "Molecular Mechanisms of Mitochondrial Transport in Neurons." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556433.

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Dynamic mitochondrial transport into axons and dendrites of neuronal cells is critical for sustaining neuronal excitability, synaptic transmission, and cell survival. Failure of mitochondrial transport is the direct cause of some neurodegenerative diseases, and an aggravating factor for many others. Mitochondrial transport regulation involves many proteins; factoring prominently among them are the atypical mitochondrial GTPase Miro and the Milton/TRAK adaptor proteins, which link microtubule (MT) motors to mitochondria. Motors of the kinesin family mediate mitochondrial transport towards the p
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47

Straube, Anne. "Struktur und zelluläre Funktionen von cytoplasmatischem Dynein und Organisation des Mikrotubuli-Cytoskeletts in Ustilago maydis." [S.l.] : [s.n.], 2003. http://archiv.ub.uni-marburg.de/diss/z2003/0175.

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48

Bähr, Jennifer. "Einfluss der Dynein-Mutation auf zelluläre Mediatoren der neuronalen Signaltransduktion im Cra1-Mausmodell der Motoneurondegeneration." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106332.

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49

Ban, Kenneth. "Localized regulation of the anaphase-promoting complex by the Emi1/NuMA/Dynein-dynactin (END) network /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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50

Osseman, Quentin. "Analyse du transport intracytoplasmique de la capside du virus de l’hépatite B : analyse des interactions entre les capsides du VHB et les chaînes du complexe de la dynéine." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0304/document.

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Abstract:
Le virus de l’hépatite B (VHB) utilise la machinerie transcriptionnelle nucléaire pour sa réplication. Le génome viral est transporté de la périphérie cellulaire à l’enveloppe nucléaire. Généralement, ce transport intracytoplasmique rétrograde est facilité par le réseau de Mt via l’utilisation du complexe moteur de la dynéine. Nous avons montré que le transport des capsides du VHB dépend des Mt, ce qui permet l’adressage des capsides aux complexes du pore nucléaire (NPC) ; lequel est requis pour l’étape de libération du génome de la capside dans le noyau.Dans cette étude, nous avons utilisé de
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