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1

Thouvenin, Olivier, Mathias Fink, and Albert Claude Boccara. "Dynamic multimodal full-field optical coherence tomography and fluorescence structured illumination microscopy." Journal of Biomedical Optics 22, no. 02 (February 14, 2017): 1. http://dx.doi.org/10.1117/1.jbo.22.2.026004.

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2

Tian Haoying, 田浩颍, 汤丰锐 Tang Fengrui, 高万荣 Gao Wanrong, and 朱越 Zhu Yue. "动态散射光测量在全场光学相干层析技术中的应用." Chinese Journal of Lasers 49, no. 5 (2022): 0507202. http://dx.doi.org/10.3788/cjl202249.0507202.

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3

Zhang, Jinze, Viacheslav Mazlin, Keyi Fei, Albert Claude Boccara, Jin Yuan, and Peng Xiao. "Time-domain full-field optical coherence tomography (TD-FF-OCT) in ophthalmic imaging." Therapeutic Advances in Chronic Disease 14 (January 2023): 204062232311701. http://dx.doi.org/10.1177/20406223231170146.

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Ocular imaging plays an irreplaceable role in the evaluation of eye diseases. Developing cellular-resolution ophthalmic imaging technique for more accurate and effective diagnosis and pathogenesis analysis of ocular diseases is a hot topic in the cross-cutting areas of ophthalmology and imaging. Currently, ocular imaging with traditional optical coherence tomography (OCT) is limited in lateral resolution and thus can hardly resolve cellular structures. Conventional OCT technology obtains ultra-high resolution at the expense of a certain imaging range and cannot achieve full field of view imaging. In the early years, Time-domain full-field OCT (TD-FF-OCT) has been mainly used for ex vivo ophthalmic tissue studies, limited by the low speed and low full-well capacity of existing two-dimensional (2D) cameras. The recent improvements in system design opened new imaging possibilities for in vivo applications thanks to its distinctive optical properties of TD-FF-OCT such as a spatial resolution almost insensitive to aberrations, and the possibility to control the curvature of the optical slice. This review also attempts to look at the future directions of TD-FF-OCT evolution, for example, the potential transfer of the functional-imaging dynamic TD-FF-OCT from the ex vivo into in vivo use and its expected benefit in basic and clinical ophthalmic research. Through non-invasive, wide-field, and cellular-resolution imaging, TD-FF-OCT has great potential to be the next-generation imaging modality to improve our understanding of human eye physiology and pathology.
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Leong-Hoi, Audrey, Paul C. Montgomery, Bruno Serio, Patrice Twardowski, and Wilfried Uhring. "High-dynamic-range microscope imaging based on exposure bracketing in full-field optical coherence tomography." Optics Letters 41, no. 7 (March 16, 2016): 1313. http://dx.doi.org/10.1364/ol.41.001313.

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5

Chen, Keyu, Stephanie Swanson, and Kostadinka Bizheva. "Line-field dynamic optical coherence tomography platform for volumetric assessment of biological tissues." Biomedical Optics Express 15, no. 7 (June 7, 2024): 4162. http://dx.doi.org/10.1364/boe.527797.

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Dynamic optical coherence tomography (dOCT) utilizes time-dependent signal intensity fluctuations to enhance contrast in OCT images and indirectly probe physiological processes in cells. Majority of the dOCT studies published so far are based on acquisition of 2D images (B-scans or C-scans) by utilizing point-scanning Fourier domain (spectral or swept-source) OCT or full-field OCT respectively, primarily due to limitations in the image acquisition rate. Here we introduce a novel, high-speed spectral domain line-field dOCT (SD-LF-dOCT) system and image acquisition protocols designed for fast, volumetric dOCT imaging of biological tissues. The imaging probe is based on an exchangeable afocal lens pair that enables selection of combinations of transverse resolution (from 1.1 µm to 6.4 µm) and FOV (from 250 × 250 µm2 to 1.4 × 1.4 mm2), suitable for different biomedical applications. The system offers axial resolution of ∼ 1.9 µm in biological tissue, assuming an average refractive index of 1.38. Maximum sensitivity of 90.5 dB is achieved for 3.5 mW optical imaging power at the tissue surface and maximum camera acquisition rate of 2,000 fps. Volumetric dOCT images acquired with the SD-LF-dOCT system from plant tissue (cucumber), animal tissue (mouse liver) and human prostate carcinoma spheroids allow for volumetric visualization of the tissues’ cellular and sub-cellular structures and assessment of cellular motility.
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Teston, Eliott, Marc Sautour, Léa Boulnois, Nicolas Augey, Abdellah Dighab, Christophe Guillet, Dea Garcia-Hermoso, et al. "Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics." Journal of Fungi 10, no. 11 (October 26, 2024): 741. http://dx.doi.org/10.3390/jof10110741.

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Live-cell imaging generally requires pretreatment with fluorophores to either monitor cellular functions or the dynamics of intracellular processes and structures. We have recently introduced full-field optical coherence tomography for the label-free live-cell imaging of fungi with potential clinical applications for the diagnosis of invasive fungal mold infections. While both the spatial resolution and technical set up of this technology are more likely designed for the histopathological analysis of tissue biopsies, there is to our knowledge no previous work reporting the use of a light interference-based optical technique for direct mycological examination and monitoring of intracellular processes. We describe the first application of dynamic full-field optical transmission tomography (D-FF-OTT) to achieve both high-resolution and live-cell imaging of fungi. First, D-FF-OTT allowed for the precise examination and identification of several elementary structures within a selection of fungal species commonly known to be responsible for invasive fungal infections such as Candida albicans, Aspergillus fumigatus, or Rhizopus arrhizus. Furthermore, D-FF-OTT revealed the intracellular trafficking of organelles and vesicles related to metabolic processes of living fungi, thus opening new perspectives in fast fungal infection diagnostics.
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Apelian, Clement, Fabrice Harms, Olivier Thouvenin, and A. Claude Boccara. "Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis." Biomedical Optics Express 7, no. 4 (March 24, 2016): 1511. http://dx.doi.org/10.1364/boe.7.001511.

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8

Hrebesh, Molly Subhash, Razvan Dabu, and Manabu Sato. "In vivo imaging of dynamic biological specimen by real-time single-shot full-field optical coherence tomography." Optics Communications 282, no. 4 (February 2009): 674–83. http://dx.doi.org/10.1016/j.optcom.2008.10.070.

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9

Quénéhervé, Lucille, Raphael Olivier, Michalina J. Gora, Céline Bossard, Jean-François Mosnier, Emilie Benoit a la Guillaume, Claude Boccara, Charlène Brochard, Michel Neunlist, and Emmanuel Coron. "Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies." Gut 70, no. 1 (May 23, 2020): 6–8. http://dx.doi.org/10.1136/gutjnl-2020-321228.

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Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5 min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged individual epithelial cells of the mucosal lining with a cellular or subcellular resolution and identified cellular components of the lamina propria. FFOCT represents a promising dye-free imaging tool for on-site analysis of gut tissue remodelling.
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10

Yang, Houpu, Shuwei Zhang, Peng Liu, Lin Cheng, Fuzhong Tong, Hongjun Liu, Siyuan Wang, et al. "Use of high‐resolution full‐field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery." Cancer 126, S16 (July 25, 2020): 3847–56. http://dx.doi.org/10.1002/cncr.32838.

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11

Leroux, Charles-Edouard, Fabien Bertillot, Olivier Thouvenin, and Albert-Claude Boccara. "Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport." Biomedical Optics Express 7, no. 11 (October 7, 2016): 4501. http://dx.doi.org/10.1364/boe.7.004501.

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12

Simon, Alexis, Yasmina Badachi, Jacques Ropers, Isaura Laurent, Lida Dong, Elisabeth Da Maia, Agnes Bourcier, Geoffroy Canlorbe, and Catherine Uzan. "Abstract PO1-07-08: Value of high resolution full field optical coherence tomography and dynamic cell imaging (D-FFOCT) for one-stop rapid diagnosis breast clinic." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO1–07–08—PO1–07–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-07-08.

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Abstract BACKGROUND: Full field optical coherence tomography combined to dynamic cell imaging (D-FFOCT) is a new, simple to use, nondestructive, quick technique than can provide sufficient spatial resolution to mimic histopathological analysis. The objective of this study was to evaluate diagnostic performance of D-FFOCT for one-stop rapid diagnosis breast clinic. METHODS: D-FFOCT was applied to fresh untreated breast and nodes biopsies. Four different readers (senior and junior radiologist, surgeon and pathologist) analyzed the samples without knowing final histological diagnosis or ACR classification. The results were compared to conventional processing and staining (Hematoxylin-eosin). RESULTS: A total of 217 biopsies were performed on 152 patients. There were 144 breast biopsies and 61 lymph nodes with 101 infiltrative cancers (49,27%), 99 benign lesions (48,29%), 3 ductal in situ carcinoma (1,46%) and 2 atypias (0,98%). The diagnostic performances results were as follow: sensitivity: 77% [0.7;0.82], specificity: 64% [0.58;0.71], PPV: 74% [0.68;0.78] and NPV: 75% [0.72;0.78]. A large images atlas was created as well as a diagnosis algorithm from the readers experience. CONCLUSION: D-FFOCT provides interesting results defining malignancy on fresh breast and nodes samples. By training with the diagnosis algorithm and the images atlas or by using machine learning, radiologists could obtain even better outcomes allowing quick detection of breast cancer and lymph node involvement. diagnosis algorithm Figure 1 Images in DCI and FFOCT Two infiltrating cancer diagnosed on pathology (A,B). Focusing on cells (C). Normal galactophoric duct (D). Adenofibroma (E) Citation Format: Alexis Simon, Yasmina Badachi, Jacques Ropers, Isaura Laurent, Lida Dong, Elisabeth Da Maia, Agnes Bourcier, Geoffroy Canlorbe, Catherine Uzan. Value of high resolution full field optical coherence tomography and dynamic cell imaging (D-FFOCT) for one-stop rapid diagnosis breast clinic [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-07-08.
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13

Stremplewski, Patrycjusz, Maciej Nowakowski, Dawid Borycki, and Maciej Wojtkowski. "Fast method of speckle suppression for reflection phase microscopy." Photonics Letters of Poland 10, no. 4 (December 31, 2018): 118. http://dx.doi.org/10.4302/plp.v10i4.850.

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Light propagating in turbid medium is randomly altered by optical inhomogeneities, which not only change the momentum and polarization of light but also generate a speckle pattern. All these effects strongly limit capabilities of laser based, quantitative phase–sensitive optical biomedical imaging modalities by hindering a reconstruction of phase distribution. Here we introduce the method of rapid incident light modulation, which allows to suppress speckle noise and preserve the spatial phase distribution. We implement this approach in the full-field Michelson interferometer, where the incident light is modulated using the digitalmicromirror device (DMD). Full Text: PDF ReferencesF. Zernike, "Phase contrast, a new method for the microscopic observation of transparent objects part II," Physica 9, 974-986 (1942). CrossRef M. C. Pitter, C. W. See, and M. G. Somekh, "Full-field heterodyne interference microscope with spatially incoherent illumination," Opt. Lett. 29, 1200-1202 (2004). CrossRef N. B. E. Sawyer, S. P. Morgan, M. G. Somekh, C. W. See, X. F. Cao, B. Y. Shekunov, and E. Astrakharchik, "Wide field amplitude and phase confocal microscope with parallel phase stepping," Review of Scientific Instruments 72, 3793-3801 (2001). CrossRef G. W. John and I. H. Keith, "A diffuser-based optical sectioning fluorescence microscope," Measurement Science and Technology 24, 125404 (2013). CrossRef S. Lowenthal and D. Joyeux, "Speckle Removal by a Slowly Moving Diffuser Associated with a Motionless Diffuser," J. Opt. Soc. Am. 61, 847-851 (1971). CrossRef S. Kubota and J. W. Goodman, "Very efficient speckle contrast reduction realized by moving diffuser device," Applied Optics 49, 4385-4391 (2010). CrossRef Y. Li, H. Lee, and E. Wolf, "The effect of a moving diffuser on a random electromagnetic beam," Journal of Modern Optics 52, 791-796 (2005). CrossRef C.-Y. Chen, W.-C. Su, C.-H. Lin, M.-D. Ke, Q.-L. Deng, and K.-Y. Chiu, "Reduction of speckles and distortion in projection system by using a rotating diffuser," Optical Review 19, 440-443 (2012). CrossRef J. Lehtolahti, M. Kuittinen, J. Turunen, and J. Tervo, "Coherence modulation by deterministic rotating diffusers," Opt. Express 23, 10453-10466 (2015). CrossRef J.-W. Pan and C.-H. Shih, "Speckle reduction and maintaining contrast in a LASER pico-projector using a vibrating symmetric diffuser," Opt. Express 22, 6464-6477 (2014). CrossRef J. I. Trisnadi, "Hadamard speckle contrast reduction," Optics Letters 29, 11-13 (2004). CrossRef M. Szkulmowski, I. Gorczynska, D. Szlag, M. Sylwestrzak, A. Kowalczyk, and M. Wojtkowski, "Efficient reduction of speckle noise in Optical Coherence Tomography," Opt. Express 20, 1337-1359 (2012). CrossRef J. W. Goodman, Speckle phenomena in optics: theory and applications (Roberts and Company Publishers, 2006). DirectLink Y. Choi, P. Hosseini, W. Choi, R. R. Dasari, P. T. C. So, and Z. Yaqoob, "Dynamic speckle illumination wide-field reflection phase microscopy," Opt. Lett. 39, 6062-6065 (2014). CrossRef Y. Choi, T. D. Yang, K. J. Lee, and W. Choi, "Full-field and single-shot quantitative phase microscopy using dynamic speckle illumination," Opt. Lett. 36, 2465-2467 (2011). CrossRef R. Zhou, D. Jin, P. Hosseini, V. R. Singh, Y.-h. Kim, C. Kuang, R. R. Dasari, Z. Yaqoob, and P. T. C. So, "Modeling the depth-sectioning effect in reflection-mode dynamic speckle-field interferometric microscopy," Optics Express 25, 130-143 (2017). CrossRef M. Schmitz, T. Rothe, and A. Kienle, "Evaluation of a spectrally resolved scattering microscope," Biomedical optics express 2, 2665-2678 (2011). CrossRef P. Judy, The line spread function and modulation transfer function of a computer tomography scanner, Med. Phys (1976), Vol. 3, pp. 233-236. CrossRef
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14

Zhang, Shuwei, Houpu Yang, Jin Zhao, and Shu Wang. "Abstract PO5-07-05: Deep learning can diagnose axillary lymph node metastases on optical virtual histologic images in breast cancer patients during surgery." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO5–07–05—PO5–07–05. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-07-05.

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Abstract Background: Reliable identification of axillary lymph node (ALN) involvement in patients with breast cancer allows for definitive axillary dissection at the time of the initial surgery, thus avoiding the need for a separate axillary surgery. However, conventional intraoperative ALN diagnostic methods are time-consuming and labor-intensive and can result in tissue destruction. Dynamic full field optical coherence tomography, also called dynamic cell imaging (DCI), has been developed and validated to offer rapid and label-free histologic approximations of metastatic and non-metastatic ALNs. In this study, we aim to optimize the diagnostic pipeline with an automated approach and present the results of using a deep learning (DL) algorithm with DCI to predict ALN status intraoperatively in patients with breast cancer. Methods: Breast cancer patients who required ALN staging were enrolled prospectively in this study. DCI was applied to bisected fresh lymph nodes in a non-destructive manner, and the specimens were subsequently sent for histopathological examination, regarded as the gold standard for comparison. A DL model was trained and fine-tuned on over 80,000 DCI images, and the results were mapped to slide level to predict ALN diagnosis. Results: Total 607 DCI slides of ALNs with 112,852 cropped patches were included in the study. The DL model was trained and validated on a dataset containing 481 slides and tested on an independent testing dataset with 126 slides. In the test set, the DL algorithm yielded accuracy for prediction of ALN status, with sensitivity and specificity of 91.9% and 95.5% and an area under the receiver operating characteristic curve (AUC) of 0.937 (95% confidence interval [CI]: 0.912-0.957) at slide level. Conclusion: These results demonstrate that the integration of DCI with DL is rapid, reduces labor requirements and minimizes tissue destruction. Meanwhile, this algorithm had high classification accuracy to predict the metastatic burden of ALNs for patients with breast cancer. Citation Format: Shuwei Zhang, Houpu Yang, Jin Zhao, Shu Wang. Deep learning can diagnose axillary lymph node metastases on optical virtual histologic images in breast cancer patients during surgery [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-07-05.
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15

Auksorius, Egidijus, and A. Claude Boccara. "Dark-field full-field optical coherence tomography." Optics Letters 40, no. 14 (July 6, 2015): 3272. http://dx.doi.org/10.1364/ol.40.003272.

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16

Mekhileri, Naveen Vijayan, Laetitia Andrique, Gaëlle Recher, Pierre Nassoy, and Amaury Badon. "Adaptive coherence volume in full-field optical coherence tomography." OSA Continuum 4, no. 11 (November 1, 2021): 2805. http://dx.doi.org/10.1364/osac.442310.

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17

SATO, Manabu, and Yuuki WATANABE. "Quadrature-Fringes Full-field Optical Coherence Tomography." Review of Laser Engineering 34, no. 7 (2006): 488–93. http://dx.doi.org/10.2184/lsj.34.488.

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18

Vabre, L., A. Dubois, and A. C. Boccara. "Thermal-light full-field optical coherence tomography." Optics Letters 27, no. 7 (April 1, 2002): 530. http://dx.doi.org/10.1364/ol.27.000530.

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19

Moneron, Gael, Albert-Claude Boccara, and Arnaud Dubois. "Polarization-sensitive full-field optical coherence tomography." Optics Letters 32, no. 14 (July 10, 2007): 2058. http://dx.doi.org/10.1364/ol.32.002058.

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20

Xiao, Peng, Mathias Fink, and Albert Claude Boccara. "Adaptive optics full-field optical coherence tomography." Journal of Biomedical Optics 21, no. 12 (September 22, 2016): 121505. http://dx.doi.org/10.1117/1.jbo.21.12.121505.

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21

Dubois, Arnaud, Kate Grieve, Gael Moneron, Romain Lecaque, Laurent Vabre, and Claude Boccara. "Ultrahigh-resolution full-field optical coherence tomography." Applied Optics 43, no. 14 (May 10, 2004): 2874. http://dx.doi.org/10.1364/ao.43.002874.

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22

Karnowski, Karol Marian, Ewa Mączyńska, Maciej Nowakowski, Bartłomiej Kałużny, Ireneusz Grulkowski, and Maciej Wojtkowski. "Impact of diurnal IOP variations on the dynamic corneal hysteresis measured with air-puff swept-source OCT." Photonics Letters of Poland 10, no. 3 (October 1, 2018): 64. http://dx.doi.org/10.4302/plp.v10i3.848.

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The deformation amplitudes measured with air-puff OCT are sensitive to both (intraocular pressure) IOP and biomechanical properties of the cornea. Analysis of the amplitudes of corneal deformation is challenging due to interrelation of IOP and corneal biomechanics. In this study, we used natural diurnal IOP fluctuations to investigate corneal deformations in a number of subjects whose eyes were measured multiple times during a day. The results of analysis, based on corneal hysteresis, revealed a corneal hysteresis parameter, which remains constant during a day for each individual eye. We hypothesize that above-mentioned metric might correlate with biomechanical properties of the cornea without influence of IOP. Full Text: PDF ReferencesMeek KM, Tuft SJ, Huang Y, Gill PS, Hayes S, Newton RH, Bron AJ, "Changes in Collagen Orientation and Distribution in Keratoconus Corneas", Invest Ophthalmol Vis Sci, 2005. 46(6): p. 1948-56. CrossRef Zimmermann DR, Fisher RW, Winterhalter KH, Witmer R, Vaughan L, "Comparative studies of collagens in normal and keratoconus corneas", Exp Eye Res, 1988. 46(3): p. 431-42. CrossRef Andreassen TT, Simonsen AH, and Oxlund H, "Biomechanical properties of keratoconus and normal corneas", Experimental Eye Research, 1980. 31(4): p. 435-441. CrossRef Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M, "Reduction of Intraocular Pressure and Glaucoma Progression", Arch Ophthalmol, 2002. 120(10): p. 1268-79. CrossRef Chauhan BC and Drance SM, "The influence of intraocular pressure on visual field damage in patients with normal-tension and high-tension glaucoma", Investigative Ophthalmology & Visual Science, 1990. 31(11): p. 2367-2372. DirectLink Gelaw Y, "The impact of central corneal thickness on intraocular pressure among Ethiopian glaucoma patients: a cross-sectional study", BMC Ophthalmology, 2012. 12(1): p. 58. CrossRef Doughty MJ and Zaman ML, "Human Corneal Thickness and Its Impact on Intraocular Pressure Measures: A Review and Meta-analysis Approach", Surv Ophthalmol, 2000. 44(5): p. 367-408. CrossRef Liu J, and Roberts CJ, "Influence of corneal biomechanical properties on intraocular pressure measurement: Quantitative analysis", J Cataract Refract Surg, 2005. 31(1): p. 146-55. CrossRef Ehlers N, Hansen FK, and Aasved H, "Biometric Correlations of Corneal Thickness", Acta Ophthalmol (Copenh), 1975. 53(4): p. 652-9. CrossRef Harada Y, Hirose N, Tawara A, "The Influence of Central Corneal Thickness and Corneal Curvature Radius on The Intraocular Pressure as Measured By Different Tonometers: Noncontact and Goldmann Applanation Tonometers", J Glaucoma, 2008. 17(8): p. 619-25. CrossRef Alonso-Caneiro D, Karnowski K, Kaluzny BJ, Kowalczyk A, Wojtkowski M, "Assessment of corneal dynamics with high-speed swept source Optical Coherence Tomography combined with an air puff system", Optics Express, 2011. 19(15): p. 14188-14199. CrossRef Dorronsoro C, Pascual D, Perez-Merino P, Kling S and Marcos S, "Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas", Biomedical Optics Express, 2012. 3(3): p. 473-487. CrossRef Karnowski K, Kaluzny BJ, Szkulmowski M, Gora M, Wojtkowski M, "Corneal topography with high-speed swept source OCT in clinical examination", Biomedical Optics Express, 2011. 2(9): p. 2709-2720. CrossRef A. N. S. Institute, "American National Standard for Safe use of Lasers," (American National Standards Institute, Orlando, FL, 2000) DirectLink David R, Zangwill L, Briscoe D, Dagan M, Yagev R, Yassur Y, "Diurnal intraocular pressure variations: an analysis of 690 diurnal curves", Br J Ophthamlom, 1992, 76(5): p. 280-282 CrossRef Maczynska E, Karnowski K, Szulzycki K, Malinowska M, Dolezyczek H, Cichanski A, Wojtkowski M, Kaluzny BJ, Grulkowski I, Journal of Biophotonics (to be published).
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Lawman, Samuel, Zijian Zhang, Yao-Chun Shen, and Yalin Zheng. "Line Field Optical Coherence Tomography." Photonics 9, no. 12 (December 7, 2022): 946. http://dx.doi.org/10.3390/photonics9120946.

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The line field (LF) design choice for the lateral image formation mechanism (lateral format) has historically been a fraction of the whole optical coherence tomography (OCT) field. However, as the OCT technology develops, the parallelised acquisition of LF-OCT formats (LF-time domain (TD)-OCT, LF-spectral domain (SD)-OCT, LF-swept source (SS)-OCT) offers benefits and capabilities, which may mean it is now becoming more mainstream. Prior reviews on OCT have focused on scanning point (SP) and, to a lesser extent, full field (FF), lateral formats, with, to our knowledge, no prior review specifically on the LF lateral format. Here, we address this gap in the literature by reviewing the history of each LF-OCT format, identifying the applications it has had and providing generic system design overviews. We then provide an analysis and discussion of the benefits and drawbacks of the format.
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Auksorius, Egidijus, and A. Claude Boccara. "High-throughput dark-field full-field optical coherence tomography." Optics Letters 45, no. 2 (January 10, 2020): 455. http://dx.doi.org/10.1364/ol.381888.

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25

Yang Ya-Liang, Ding Zhi-Hua, Wang Kai, Wu Ling, and Wu Lan. "Development of full-field optical coherence tomography system." Acta Physica Sinica 58, no. 3 (2009): 1773. http://dx.doi.org/10.7498/aps.58.1773.

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GAO Wan-rong, 高万荣, 陈一丹 CHEN Yi-dan, 刘畅 LIU Chang, 张秋庭 ZHANG Qiu-ting, and 朱越 ZHU Yue. "FPGA-based Rapid Full Field Optical Coherence Tomography." ACTA PHOTONICA SINICA 45, no. 6 (2016): 611001. http://dx.doi.org/10.3788/gzxb20164506.0611001.

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27

AKIBA, Masahiro, and Kin Pui CHAN. "Full-field Optical Coherence Tomography using Parallel Detection." Review of Laser Engineering 34, no. 7 (2006): 494–98. http://dx.doi.org/10.2184/lsj.34.494.

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28

Dubois, Arnaud. "Spectroscopic polarization-sensitive full-field optical coherence tomography." Optics Express 20, no. 9 (April 17, 2012): 9962. http://dx.doi.org/10.1364/oe.20.009962.

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29

Laude, Blandine, Antonello De Martino, Bernard Drévillon, Laurence Benattar, and Laurent Schwartz. "Full-field optical coherence tomography with thermal light." Applied Optics 41, no. 31 (November 1, 2002): 6637. http://dx.doi.org/10.1364/ao.41.006637.

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30

Moneron, G., A. C. Boccara, and A. Dubois. "Stroboscopic ultrahigh-resolution full-field optical coherence tomography." Optics Letters 30, no. 11 (June 1, 2005): 1351. http://dx.doi.org/10.1364/ol.30.001351.

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31

Li, Jinxi, Xing Bai, Zhongzhuo Yang, Yujie Wang, Xingyu Chen, and Xin Zhou. "Time domain ptychographic full field optical coherence tomography." Laser Physics Letters 20, no. 4 (February 20, 2023): 045601. http://dx.doi.org/10.1088/1612-202x/aca979.

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Abstract Full field optical coherence tomography (FF-OCT) has the advantage of ultrahigh lateral resolution (∼1 µm) resulting from a relatively high numerical aperture (NA) micro objective. However, usually the field of view of micro objective is limited. Furthermore, in vivo imaging, significant motion artifacts limit the performance of traditional FF-OCT where the quality of the restored image is generally degraded due to the influence of motion artifacts. In this paper, we propose a method of edge-preserving ptychography based on dual-balanced time domain FF-OCT, which we can call it time-domain ptychography full field optical coherence tomography (TD-POCT). The method combines the advantages of both ptychography and dual-balanced FF-OCT, which can overcome the limitation of the field for view of micro objective and suppresses motion blur. Moreover, this method can recover not only the amplitude of each layer, but also the phase information. So in addition to tomography, the system can also be used for surface 3D object reconstruction. Numerical simulation verifies that both the horizontal and vertical resolution can reach a few microns.
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Tsai, Chien-Chung, Chia-Kai Chang, Kuang-Yu Hsu, Tuan-Shu Ho, Ming-Yi Lin, Jeng-Wei Tjiu, and Sheng-Lung Huang. "Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography." Biomedical Optics Express 5, no. 9 (August 8, 2014): 3001. http://dx.doi.org/10.1364/boe.5.003001.

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Seromenho, Emmanuel Martins, Agathe Marmin, Sybille Facca, Nadia Bahlouli, Stephane Perrin, and Amir Nahas. "Single-shot off-axis full-field optical coherence tomography." Applied Physics Letters 121, no. 11 (September 12, 2022): 113702. http://dx.doi.org/10.1063/5.0100944.

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Full field optical coherence tomography (FF-OCT) enables high-resolution in-depth imaging within turbid media. In this work, we present a simple approach which combines FF-OCT with off-axis interferometry for reconstruction of en-face images. With low spatial and temporal coherence illumination, this method is able to extract an FF-OCT image from only one interference acquisition. This method is described, and the proof-of-concept is demonstrated through the observation of scattering samples such as organic and ex vivo biomedical samples.
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LEE, Byeong Ha, Woo June CHOI, and Jihoon NA. "Full-Field Optical Coherence Tomography Based on Hilbert Transform." Review of Laser Engineering 36, APLS (2008): 1347–50. http://dx.doi.org/10.2184/lsj.36.1347.

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Považay, Boris, Angelika Unterhuber, Boris Hermann, Harald Sattmann, Holger Arthaber, and Wolfgang Drexler. "Full-field time-encoded frequency-domain optical coherence tomography." Optics Express 14, no. 17 (August 21, 2006): 7661. http://dx.doi.org/10.1364/oe.14.007661.

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Sacchet, Delphine, Michal Brzezinski, Julien Moreau, Patrick Georges, and Arnaud Dubois. "Motion artifact suppression in full-field optical coherence tomography." Applied Optics 49, no. 9 (March 10, 2010): 1480. http://dx.doi.org/10.1364/ao.49.001480.

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Ford, H. D., and R. P. Tatam. "Fibre imaging bundles for full-field optical coherence tomography." Measurement Science and Technology 18, no. 9 (August 10, 2007): 2949–57. http://dx.doi.org/10.1088/0957-0233/18/9/027.

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Wang, Jingyu, Adrian Bradu, George Dobre, and Adrian Podoleanu. "Full-Field Swept Source Master-Slave Optical Coherence Tomography." IEEE Photonics Journal 7, no. 4 (August 2015): 1–14. http://dx.doi.org/10.1109/jphot.2015.2461571.

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Ibarra-Borja, Zeferino, Carlos Sevilla-Gutiérrez, Roberto Ramírez-Alarcón, Hector Cruz-Ramírez, and Alfred B. U’Ren. "Experimental demonstration of full-field quantum optical coherence tomography." Photonics Research 8, no. 1 (December 19, 2019): 51. http://dx.doi.org/10.1364/prj.8.000051.

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Wojtkowski, Maciej, Patrycjusz Stremplewski, Egidijus Auksorius, and Dawid Borycki. "Spatio-Temporal Optical Coherence Imaging – a new tool for in vivo microscopy." Photonics Letters of Poland 11, no. 2 (July 1, 2019): 44. http://dx.doi.org/10.4302/plp.v11i2.905.

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Optical Coherence Imaging (OCI) including Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) uses interferometric detection to generate high-resolution volumetric images of the sample at high speeds. Such capabilities are significant for in vivo imaging, including ophthalmology, brain, intravascular imaging, as well as endoscopic examination. Instrumentation and software development allowed to create many clinical instruments. Nevertheless, most of OCI setups scan the incident light laterally. Hence, OCI can be further extended by wide-field illumination and detection. This approach, however, is very susceptible to the so-called crosstalk-generated noise. Here, we describe our novel approach to overcome this issue with spatio-temporal optical coherence manipulation (STOC), which employs spatial phase modulation of the incident light. Full Text: PDF ReferencesL. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, "Ballistic 2-D Imaging Through Scattering Walls Using an Ultrafast Optical Kerr Gate", Science 253, 769-771 (1991). CrossRef D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al., "Optical coherence tomography", Science 254, 1178-1181 (1991). CrossRef J. A. Izatt, E. A. Swanson, J. G. Fujimoto, M. R. Hee, and G. M. Owen, "Optical coherence microscopy in scattering media", Opt. Lett. 19, 590-592 (1994). CrossRef D. Borycki, M. Nowakowski, and M. Wojtkowski, "Control of the optical field coherence by spatiotemporal light modulation", Opt. Lett. 38, 4817-4820 (2013). CrossRef D. Borycki, M. Hamkalo, M. Nowakowski, M. Szkulmowski, and M. Wojtkowski, "Spatiotemporal optical coherence (STOC) manipulation suppresses coherent cross-talk in full-field swept-source optical coherence tomography", Biomed. Opt. Express 10, 2032-2054 (2019). CrossRef P. Stremplewski, E. Auksorius, P. Wnuk, L. Kozon, P. Garstecki, and M. Wojtkowski, "In vivo volumetric imaging by crosstalk-free full-field OCT", Optica 6, 608-617 (2019). CrossRef L. Vabre, A. Dubois, and A. C. Boccara, "Thermal-light full-field optical coherence tomography", Opt. Lett. 27, 530-532 (2002). CrossRef M. Laubscher, M. Ducros, B. Karamata, T. Lasser, and R. Salathé, "Video-rate three-dimensional optical coherence tomography", Opt. Express 10, 429-435 (2002). CrossRef Dubois and A. C. Boccara, Full-Field Optical Coherence Tomography, (Springer Berlin Heidelberg, Berlin, Heidelberg, 2008), pp. 565-591. CrossRef O. Thouvenin, K. Grieve, P. Xiao, C. Apelian, and A. C. Boccara, "En face coherence microscopy [Invited]", Biomedical Opt. Express 8, 622-639 (2017). CrossRef F. Fercher, C. K. Hitzenberger, M. Sticker, E. Moreno-Barriuso, R. Leitgeb, W. Drexler, and H. Sattmann, "A thermal light source technique for optical coherence tomography", Optics Commun. 185, 57-64 (2000). CrossRef R. A. Leitgeb, "En face optical coherence tomography: a technology review [Invited]", Biomed Opt Express 10, 2177-2201 (2019). CrossRef J. Fujimoto and W. Drexler, Introduction to Optical Coherence Tomography, (Springer, Berlin, Heidelberg, 2008), pp. 1-45. CrossRef J. A. Izatt, M. A. Choma, and A.-H. Dhalla, Theory of Optical Coherence Tomography, (Springer International Publishing, Cham, 2015), pp. 65-94. CrossRef
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Chang, Shoude, Sherif Sherif, Youxin Mao, and Costel Flueraru. "Large Area Full-Field Optical Coherence Tomography and its Applications." Open Optics Journal 2, no. 1 (March 31, 2008): 10–20. http://dx.doi.org/10.2174/1874328500802010010.

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Zhu Yue, 朱越, and 高万荣 Gao Wanrong. "High-Resolution Full-Field Optical Coherence Tomography for Biological Tissue." Chinese Journal of Lasers 41, no. 8 (2014): 0804002. http://dx.doi.org/10.3788/cjl201441.0804002.

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Cuartas-Vélez, Carlos, Sebastián Ruiz-Lopera, Néstor Uribe-Patarroyo, and René Restrepo. "Lab-made accessible full-field optical coherence tomography imaging system." Optica Pura y Aplicada 52, no. 3 (September 30, 2019): 1–11. http://dx.doi.org/10.7149/opa.52.3.50308.

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Dubey, Satish Kumar, Tulsi Anna, Chandra Shakher, and Dalip Singh Mehta. "Fingerprint detection using full-field swept-source optical coherence tomography." Applied Physics Letters 91, no. 18 (October 29, 2007): 181106. http://dx.doi.org/10.1063/1.2800823.

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Guo Yingcheng, 郭英呈, 高万荣 Gao Wanrong, and 朱. 越. Zhu Yue. "Compensation Interferometer Based Tandem Full-Field Optical Coherence Tomography System." Laser & Optoelectronics Progress 54, no. 1 (2017): 011101. http://dx.doi.org/10.3788/lop54.011101.

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46

Nitta, Kouichi, Tingyu Li, Toshiki Motoyama, Osamu Matoba, and Takeaki Yoshimura. "Full-Field Optical Coherence Tomography System with Controllable Longitudinal Resolution." Japanese Journal of Applied Physics 45, no. 11 (November 8, 2006): 8897–903. http://dx.doi.org/10.1143/jjap.45.8897.

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47

Grieve, Kate, Olivier Thouvenin, Abhishek Sengupta, Vincent M. Borderie, and Michel Paques. "Appearance of the Retina With Full-Field Optical Coherence Tomography." Investigative Opthalmology & Visual Science 57, no. 9 (July 13, 2016): OCT96. http://dx.doi.org/10.1167/iovs.15-18856.

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GAO, WANRONG. "Image contrast reduction mechanism in full-field optical coherence tomography." Journal of Microscopy 261, no. 3 (November 2, 2015): 199–216. http://dx.doi.org/10.1111/jmi.12333.

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49

Buchroithner, Boris, Andrii Prylepa, Paul J. Wagner, Stefan E. Schausberger, David Stifter, and Bettina Heise. "Full-field optical coherence tomography in a balanced detection mode." Applied Optics 57, no. 29 (October 9, 2018): 8705. http://dx.doi.org/10.1364/ao.57.008705.

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Marks, Daniel L., Tyler S. Ralston, Stephen A. Boppart, and P. Scott Carney. "Inverse scattering for frequency-scanned full-field optical coherence tomography." Journal of the Optical Society of America A 24, no. 4 (March 14, 2007): 1034. http://dx.doi.org/10.1364/josaa.24.001034.

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