Journal articles: 'DyN'

1

Widyastuti, Erlinda, and Ario Imandiri. "Lamellar Body Count With Cell Dyn Emerald And Cell Dyn Ruby Methods On Preterm Birth." Journal Of Vocational Health Studies 1, no. 1 (July 3, 2017): 7. http://dx.doi.org/10.20473/jvhs.v1.i1.2017.7-10.

Full text

Abstract:

Background: Lamellar bodies are produced by pneumocyte type II cells in the lung alveoli. Lamellar bodies are present in amniotic fluid in increasing quantities as gestation advances, 1 – 5 µm in size, similar in size to small platelets and can be counted on most electronic cell counters in hematology analyzer. Lamellar body count is useful for prediction of fetal lung maturity and neonatal respiratory distress syndrome. The current gold standard for determination of fetal lung maturity is the evaluation of phospholipids in amniotic fluid samples by thin-layer chromatography, but it is time-consuming and not continuously available at most institutions. In this study we compare Cell Dyn Emerald and Cell Dyn Ruby method, which is expected to be a review for lamellar body count method. Purpose: The aim of this study was to analyze lamellar body count with Cell Dyn Emerald and Cell Dyn Ruby method on preterm birth. Methods : This was a cross sectional study. Thirty three samples study were inpatient’s amniotic fluid with premature rupture of membranes in Obstetry and Gynecology ward emergency room Dr. Soetomo Hospital Surabaya. Lamellar body count was counted with Cell Dyn emerald and Cell Dyn Ruby method. The statistical differences were assessed using the ANOVA test . Results : The results showed significant differences (t=49,04), lamellar body count with Cell Dyn Ruby method was much lower than Cell Dyn Emerald method. The lowest result with Cell Dyn Ruby method was 3.38 x 103/µL and 17 x 103/ µL with Cell Dyn Emerald method. The highest results with Cell Dyn Ruby method was 98,2 x 103/ µL and 221 x 103/ µL with Cell Dyn Emerald method. Conclusion : Lamellar body count with impedance method (Cell Dyn Emerald) is significantly higher than optic method (Cell Dyn Ruby).

APA, Harvard, Vancouver, ISO, and other styles

2

Sommer, Richard M., and Glenn Forley. "Dyn-o-Mite Fiends." Journal of Architectural Education 61, no. 3 (February 2008): 13–24. http://dx.doi.org/10.1111/j.1531-314x.2007.00165.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Azeem, M., B. J. Ruck, Binh Do Le, H. Warring, H. J. Trodahl, N. M. Strickland, A. Koo, V. Goian, and S. Kamba. "Optical response of DyN." Journal of Applied Physics 113, no. 20 (May 28, 2013): 203509. http://dx.doi.org/10.1063/1.4807647.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Sénéchal, Martin, Isabelle J. Dionne, and Martin Brochu. "Dynapenic Abdominal Obesity and Metabolic Risk Factors in Adults 50 Years of Age and Older." Journal of Aging and Health 24, no. 5 (March 26, 2012): 812–26. http://dx.doi.org/10.1177/0898264312440324.

Full text

Abstract:

Objectives: To investigate the additive effect of dynapenia and abdominal obesity on metabolic risk factors in older adults. Method: A total of 3,007 men and women from the National Health and Nutrition Examination Survey (NHANES) study were categorized as follows: (a) non-dynapenic/non-abdominally obese (N-DYN/N-AO), (b) dynapenic/non-abdominally obese (DYN/N-AO), (c) non-dynapenic/abdominally obese (N-DYN/AO), (d) dynapenic/ abdominally obese (DYN/AO) based on waist circumference (WC) and leg muscle strength tertiles. Dependent variables were lipids, glucose, blood pressure, and other chronic conditions. Results: The DYN/AO group had lower plasma HDL-chol and higher triglyceride and glucose levels than N-DYN/N-AO and DYN/N-AO groups (all p ≤ .01). Higher plasma triglyceride was observed in the DYN/AO group compared with N-DYN/AO group ( p ≤ .01). The odds of having metabolic syndrome, cardiovascular diseases, and type II diabetes were higher in DYN/AO compared with DYN/N-AO and N-DYN/N-AO. Conclusion: DYN/AO older adults might be at greater risk of metabolic alterations than those displaying dynapenia alone or those with neither abdominal obesity nor dynapenia.

APA, Harvard, Vancouver, ISO, and other styles

5

Taylor, Matthew, Thomas Puzia, Matias Gomez, and Kristin Woodley. "NGC 5128's Globular Cluster System: Is There a Dark Side?" Proceedings of the International Astronomical Union 10, S309 (July 2014): 348. http://dx.doi.org/10.1017/s1743921314010394.

Full text

Abstract:

AbstractDynamical mass estimates (${\cal M}_{\rm dyn}$) and mass-to-light ratios ($\Upsilon_{\rm dyn}$) were derived for a sample of NGC 5128's globular clusters (GCs). We find two distinct sequences in the $\Upsilon_{\rm dyn}$ − ${\cal M}_{\rm dyn}$ plane, which are well fit by power laws of the forms $\Upsilon_{\rm dyn}\propto {\cal M}_{\rm dyn}^{0.33\pm0.04}$ and $\Upsilon_{\rm dyn}\propto {\cal M}_{\rm dyn}^{0.91\pm0.04}$. The former traces bright “classical” GCs, and the latter represents objects that are dynamically dominated by large dark matter components or by abnormally massive central black holes.

APA, Harvard, Vancouver, ISO, and other styles

6

Howlett, T. A., G. M. Besser, and L. H. Rees. "Characterization of immunoreactive dynorphin in human phaeochromocytomas." Journal of Endocrinology 117, no. 1 (April 1988): 123–32. http://dx.doi.org/10.1677/joe.0.1170123.

Full text

Abstract:

ABSTRACT The prodynorphin-derived opioids, dynorphin (DYN) and α-neoendorphin (αNE) were studied in 24 human phaeochromocytomas and related tumours. Nineteen tumours, extracted in HCl (0·1 mol/l), contained concentrations of immunoreactive DYN (ir-DYN) ranging from < 0·5 to 794 pmol/g wet weight. None of the extracts in HCl contained ir-αNE (all < 2·4 pmol/g). Sephadex G-50 gel filtration chromatography of ir-DYN in HCl (0·1 mol/l) extracts of six tumours revealed three small peaks of ir-DYN of higher molecular size (approximately 12 000, 6000 and 3000 daltons), a minor peak of ir-DYN eluting just after DYN(1–17), and a broad major peak, consisting of at least three components, which was significantly retarded and eluted after the salt volume of the column. High-pressure liquid chromatography (HPLC) of these extracts revealed multiple peaks of ir-DYN, most of which did not coelute with any synthetic DYN peptides. On both gel filtration chromatography and HPLC, one of the minor peaks coeluted with DYN(1–32). None of the peaks of ir-DYN coeluted with DYN(1–17) which had been acetylated using acetic anhydride. Extracts of the same tumours in acetic acid (0·1 mol/l) yielded similar values for ir-DYN content, but parallelism in the assay was improved. Sephadex G-50 chromatography revealed a different pattern of ir-DYN with a major peak coeluting with DYN(1–17) and, in two tumours, a minor peak coeluting with DYN(1–8). Studies with HPLC revealed, however, that substantial degradation of synthetic DYN occurred during extraction in acetic acid (0·1 mol/l) in spite of the precautions taken. Phaeochromocytomas frequently contain ir-DYN in concentrations which may approach that of the mammalian pituitary. These tumours did not, however, contain ir-αNE and, with the possible exception of a small amount of DYN(1–32), the ir-DYN present did not correspond with any known sequences. Thus, whilst prodynorphin is expressed in phaeochromocytomas, it does not seem to be processed to the usual end-products, and post-translational modifications therefore seem likely. Enzymatic degradation of DYN may occur during extraction in acetic acid (0·1 mol/l), and this medium should, therefore, be avoided in studies of such labile peptides. J. Endocr. (1988) 117, 123–132

APA, Harvard, Vancouver, ISO, and other styles

7

Younes, Magdy. "Dynamic Intrinsic PEEP (PEEPi,dyn)." American Journal of Respiratory and Critical Care Medicine 162, no. 5 (November 2000): 1608–9. http://dx.doi.org/10.1164/ajrccm.162.5.ed11-00c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Akter, Salma, Jingjing Huang, Nandita Bodra, Barbara De Smet, Khadija Wahni, Debbie Rombaut, Jarne Pauwels, et al. "DYn-2 Based Identification ofArabidopsisSulfenomes." Molecular & Cellular Proteomics 14, no. 5 (February 18, 2015): 1183–200. http://dx.doi.org/10.1074/mcp.m114.046896.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Pokrant, S., and J. A. Becker. "Magnetization curves of DyN clusters." European Physical Journal D 16, no. 1 (October 2001): 165–68. http://dx.doi.org/10.1007/s100530170083.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Cnops, Lieselotte, Annemie Cuyvers, Tjing-Tjing Hu, and Lutgarde Arckens. "Immunolocalization of Dynamin I Protein in Projection Neurons of the Visual System of the Adult Cat." Journal of Experimental Neuroscience 3 (January 2009): JEN.S2921. http://dx.doi.org/10.4137/jen.s2921.

Full text

Abstract:

We here report on the immunolocalization of Dynamin I (Dyn I) in neurons of the visual system of the cat. The lateral geniculate nucleus (LGN) complex displayed abundant Dyn I immunoreactivity in typical relay cells of the X-, Y- and W-pathway. The superficial and deep layers of the superior colliculus were also populated by Dyn I-immunoreactive projection neurons of the W- and Y-cell system. In primary visual areas 17 and 18, many densely packed layer VI neurons were intensely stained. A clear Dyn I signal was also demonstrated in pyramidal neurons of supragranular layers II and III, while layer IV displayed low Dyn I immunoreactivity. Additionally, area 18 displayed larger border pyramidal neurons in layer III compared to area 17. Generally, Dyn I was localized to the cell body and dendrites of neurons, to the neuropil and sometimes also to axon bundles. Typically, the Dyn I signal was not always uniformly distributed within the somatodendritic compartment. Based on its widespread distribution mainly in projection neurons Dyn I may play a fundamental role in mature neurons of different cortical and subcortical structures of the adult mammalian brain.

APA, Harvard, Vancouver, ISO, and other styles

11

Shukla, Vijay K., Simon Lemaire, Ibrahim H. Ibrahim, Terry D. Cyr, Yanmin Chen, and Robert Michelot. "Design of potent and selective dynorphin A related peptides devoid of supraspinal motor effects in mice." Canadian Journal of Physiology and Pharmacology 71, no. 3-4 (March 1, 1993): 211–16. http://dx.doi.org/10.1139/y93-033.

Full text

Abstract:

Dynorphin A-(1 – 13)-Tyr-Leu-Phe-Asn-Gly-Pro (Dyn Ia) was previously shown to be a highly potent and selective κ opioid peptide. Four analogs of Dyn Ia are synthesized by the solid-phase procedure, introducing pseudo CH2NH linkage between positions 6 and 7 as follows: analog 1, [6ψ7 (CH2NH)]Dyn Ia; analog 2, [6ψ7 (CH2NH), D-Leu8]Dyn Ia; analog 3, [N(Me)-Tyr1, 6ψ7 (CH2NH)]Dyn Ia; and analog 4, [N(Me)-Tyr1, 6ψ7 (CH2NH), D-Leu8]Dyn Ia. The purified peptides are compared in vitro with Dyn Ia for their ability to compete with the binding of selective κ, μ, and δ opioid ligands using membrane preparations of guinea pig cerebellum (κ) and rat brain (μ and δ). The synthetic compounds are also compared in vivo in mice (intracerebroventricularly administered) for their analgesic activity against acetic acid induced writhing and their ability to produce motor dysfunction. All compounds display a high affinity (Ki = 0.5 – 1.8 nM) and a good selectivity for the κ opioid receptor, and their rank order of potency on the κ site (analog 2 > analog 1 > analog 3 > analog 4) closely parallels their potency (AD50 = 1.57–5 nmol/mouse) in inhibiting acetic acid induced writhing in mice (analog 2 > analog 1 > analog 4 > analog 3). On the other hand, all the synthetic analogs are less potent than Dyn Ia in producing motor effects, analog 2 being the least potent (CD50 = 15.4 nM as compared with 2.9 nM for Dyn Ia). Thus, analog 2 is a good model for developing Dyn A related peptides with selective antinociceptive activity.Key words: dynorphin, opioid receptors, analgesia, motor effects.

APA, Harvard, Vancouver, ISO, and other styles

12

Niwinski, A., and Irmtraut Munro. "Untersuchungen zu den Totenbuch-Papyri der 18. Dyn. Kriterien ihrer Datierung." Journal of Egyptian Archaeology 77 (1991): 212. http://dx.doi.org/10.2307/3821983.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

He, Bin, Xiaomeng Yu, Moran Margolis, Xianghua Liu, Xiaohong Leng, Yael Etzion, Fei Zheng, et al. "Live-Cell Imaging in Caenorhabditis elegans Reveals the Distinct Roles of Dynamin Self-Assembly and Guanosine Triphosphate Hydrolysis in the Removal of Apoptotic Cells." Molecular Biology of the Cell 21, no. 4 (February 15, 2010): 610–29. http://dx.doi.org/10.1091/mbc.e09-05-0440.

Full text

Abstract:

Dynamins are large GTPases that oligomerize along membranes. Dynamin's membrane fission activity is believed to underlie many of its physiological functions in membrane trafficking. Previously, we reported that DYN-1 ( Caenorhabditis elegans dynamin) drove the engulfment and degradation of apoptotic cells through promoting the recruitment and fusion of intracellular vesicles to phagocytic cups and phagosomes, an activity distinct from dynamin's well-known membrane fission activity. Here, we have detected the oligomerization of DYN-1 in living C. elegans embryos and identified DYN-1 mutations that abolish DYN-1's oligomerization or GTPase activities. Specifically, abolishing self-assembly destroys DYN-1's association with the surfaces of extending pseudopods and maturing phagosomes, whereas inactivating guanosine triphosphate (GTP) binding blocks the dissociation of DYN-1 from these membranes. Abolishing the self-assembly or GTPase activities of DYN-1 leads to common as well as differential phagosomal maturation defects. Whereas both types of mutations cause delays in the transient enrichment of the RAB-5 GTPase to phagosomal surfaces, only the self-assembly mutation but not GTP binding mutation causes failure in recruiting the RAB-7 GTPase to phagosomal surfaces. We propose that during cell corpse removal, dynamin's self-assembly and GTP hydrolysis activities establish a precise dynamic control of DYN-1's transient association to its target membranes and that this control mechanism underlies the dynamic recruitment of downstream effectors to target membranes.

APA, Harvard, Vancouver, ISO, and other styles

14

Hua, Fang, Jeffrey L. Ardell, and Carole A. Williams. "Left vagal stimulation induces dynorphin release and suppresses substance P release from the rat thoracic spinal cord during cardiac ischemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 6 (December 2004): R1468—R1477. http://dx.doi.org/10.1152/ajpregu.00251.2004.

Full text

Abstract:

Electrostimulatory forms of therapy can reduce angina that arises from activation of cardiac nociceptive afferent fibers during transient ischemia. This study sought to determine the effects of electrical stimulation of left thoracic vagal afferents (C8–T1 level) on the release of putative nociceptive [substance P (SP)] and analgesic [dynorphin (Dyn)] peptides in the dorsal horn at the T4 spinal level during coronary artery occlusion in urethane-anesthetized Sprague-Dawley rats. Release of Dyn and SP was measured by using antibody-coated microprobes. While Dyn and SP had a basal release, occlusion of the left anterior descending coronary artery only affected SP release, causing an increase from lamina I-VII. Left vagal stimulation increased Dyn release, inhibited basal SP release, and blunted the coronary artery occlusion-induced release of SP. Dyn release reflected activation of descending pathways in the thoracic spinal cord, because vagal afferent stimulation still increased the release of Dyn after bilateral dorsal rhizotomy of T2–T5. These results indicate that electrostimulatory therapy, using vagal afferent excitation, may induce analgesia, in part, via inhibition of the release of SP in the spinal cord, possibly through a Dyn-mediated neuronal interaction.

APA, Harvard, Vancouver, ISO, and other styles

15

Lloyd, David, and Menna Elfyn. "Cusan Dyn Dall / Blind Man's Kiss." World Literature Today 77, no. 3/4 (2003): 79. http://dx.doi.org/10.2307/40158192.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Weems, Peyton W., Lique M. Coolen, Stanley M. Hileman, Steven Hardy, Rick B. McCosh, Robert L. Goodman, and Michael N. Lehman. "Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe." Endocrinology 159, no. 9 (July 16, 2018): 3187–99. http://dx.doi.org/10.1210/en.2018-00435.

Full text

Abstract:

Abstract A subpopulation of neurons located within the arcuate nucleus, colocalizing kisspeptin, neurokinin B, and dynorphin (Dyn; termed KNDy neurons), represents key mediators of pulsatile GnRH secretion. The KNDy model of GnRH pulse generation proposes that Dyn terminates each pulse. However, it is unknown where and when during a pulse that Dyn is released to inhibit GnRH secretion. Dyn acts via the κ opioid receptor (KOR), and KOR is present in KNDy and GnRH neurons in sheep. KOR, similar to other G protein–coupled receptors, are internalized after exposure to ligand, and thus internalization can be used as a marker of endogenous Dyn release. Thus, we hypothesized that KOR will be internalized at pulse termination in both KNDy and GnRH neurons. To test this hypothesis, GnRH pulses were induced in gonad-intact anestrous ewes by injection of neurokinin B (NKB) into the third ventricle and animals were euthanized at times of either pulse onset or termination. NKB injections produced increased internalization of KOR within KNDy neurons during both pulse onset and termination. In contrast, KOR internalization into GnRH neurons was seen only during pulse termination, and only in GnRH neurons within the mediobasal hypothalamus (MBH). Overall, our results indicate that Dyn is released onto KNDy cells at the time of pulse onset, and continues to be released during the duration of the pulse. In contrast, Dyn is released onto MBH GnRH neurons only at pulse termination and thus actions of Dyn upon KNDy and GnRH cell bodies may be critical for pulse termination.

APA, Harvard, Vancouver, ISO, and other styles

17

Nardo, Laura, Yi Soong, Dunli Wu, I. Ross Young, David Walker, and Hazel H. Szeto. "Site and mechanism of action of dynorphin A-(1–13) andN-methyl-d-aspartate on ACTH release in fetal sheep." American Journal of Physiology-Endocrinology and Metabolism 282, no. 6 (June 1, 2002): E1301—E1307. http://dx.doi.org/10.1152/ajpendo.00527.2001.

Full text

Abstract:

Dynorphin A (Dyn A) stimulates the release of ACTH in fetal sheep, a response that involves N-methyl-d-aspartate (NMDA) receptors but not the secretogogues corticotropin-releasing hormone or arginine vasopressin. We now find that neither Dyn A-(1–13) (0.5 mg/kg, iv) nor NMDA (4 mg/kg, iv) elicits ACTH release in postnatal lambs. This led us to hypothesize that Dyn A-(1–13) and NMDA might act to release placental ACTH. However, the ability of Dyn A-(1–13), NMDA, and the κ-opioid receptor agonist U-50488H (1 mg/kg, iv) to release ACTH was lost after either fetal hypophysectomy ( n = 4) or hypothalamo-pituitary disconnection ( n = 4). These results indicate that neither the placenta nor the fetal pituitary is the site of action for these agonists and suggest a hypothalamic or suprahypothalamic site of action. Furthermore, the release of ACTH by Dyn A-(1–13) and NMDA was abolished after pretreatment with indomethacin, suggesting that they might cause the release of a prostanoid, possibly from the placenta, that subsequently acts at the hypothalamus or serves as a permissive factor in the action of Dyn A-(1–13) and NMDA at the hypothalamus.

APA, Harvard, Vancouver, ISO, and other styles

18

Dave, Chintan, Jennifer Shen, Dipayan Chaudhuri, Brent Herritt, Shannon M. Fernando, Peter M. Reardon, Peter Tanuseputro, et al. "Dynamic Assessment of Fluid Responsiveness in Surgical ICU Patients Through Stroke Volume Variation is Associated With Decreased Length of Stay and Costs: A Systematic Review and Meta-Analysis." Journal of Intensive Care Medicine 35, no. 1 (October 11, 2018): 14–23. http://dx.doi.org/10.1177/0885066618805410.

Full text

Abstract:

Static indices, such as the central venous pressure, have proven to be inaccurate predictors of fluid responsiveness. An emerging approach uses dynamic assessment of fluid responsiveness (FT-DYN), such as stroke volume variation (SVV) or surrogate dynamic variables, as more accurate measures of volume status. Recent work has demonstrated that goal-directed therapy guided by FT-DYN was associated with reduced intensive care unit (ICU) mortality; however, no study has specifically assessed this in surgical ICU patients. This study aimed to conduct a systematic review and meta-analysis on the impact of employing FT-DYN in the perioperative care of surgical ICU patients on length of stay in the ICU. As secondary objectives, we performed a cost analysis of FT-DYN and assessed the impact of FT-DYN versus standard care on hospital length of stay and mortality. We identified all randomized controlled trials (RCTs) through MEDLINE, EMBASE, and CENTRAL that examined adult patients in the ICU who were randomized to standard care or to FT-DYN from inception to September 2017. Two investigators independently reviewed search results, identified appropriate studies, and extracted data using standardized spreadsheets. A random effect meta-analysis was carried out. Eleven RCTs were included with a total of 1015 patients. The incorporation of FT-DYN through SVV in surgical patients led to shorter ICU length of stay (weighted mean difference [WMD], −1.43d; 95% confidence interval [CI], −2.09 to −0.78), shorter hospital length of stay (WMD, −1.96d; 95% CI, −2.34 to −1.59), and trended toward improved mortality (odds ratio, 0.55; 95% CI, 0.30-1.03). There was a decrease in daily ICU-related costs per patient for those who received FT-DYN in the perioperative period (WMD, US$ −1619; 95% CI, −2173.68 to −1063.26). Incorporation of FT-DYN through SVV in the perioperative care of surgical ICU patients is associated with decreased ICU length of stay, hospital length of stay, and ICU costs.

APA, Harvard, Vancouver, ISO, and other styles

19

Wiley, John W., Hylan C. Moises, Robert A. Gross, and Robert L. Macdonald. "Dynorphin A-Mediated Reduction in Multiple Calcium Currents Involves a Goα-Subtype G Protein in Rat Primary Afferent Neurons." Journal of Neurophysiology 77, no. 3 (March 1, 1997): 1338–48. http://dx.doi.org/10.1152/jn.1997.77.3.1338.

Full text

Abstract:

Wiley, John W., Hylan C. Moises, Robert A. Gross, and Robert L. Macdonald. Dynorphin A-mediated reduction in multiple calcium currents involves a Goα-subtype G protein in rat primary afferent neurons. J. Neurophysiol. 77: 1338–1348, 1997. We examined the effect of antisera directed at specific G-protein subtype(s) on dynorphin A (Dyn A)-mediated reduction of calcium currents in rat dorsal root ganglia (DRG) neurons. Whole cell patch-clamp recordings were performed on acutely dissociated neurons. Dyn A (1 μM)-mediated decrease in calcium currents was inhibited >90% by the preferential κ-receptor antagonist norbinaltorphimine. Dyn A (300–1,000 nM)-mediated reduction in calcium currents was examined during intracellular administration of antisera directed against specific regions of Goα, Gi1α/Gi2α, and Gi3α subunits. Intracellular dialysis with an antiserum specific for Goα for 20 min decreased calcium current inhibition by Dyn A (1 μM) in 13 of 15 neurons by an average of 75%. Dialysis with nonimmune serum did not affect Dyn A's action to reduce calcium currents. Intracellular dialysis with either anti-Gi1α/Gi2α or anti-Gi3α antisera did not affect Dyn A-induced changes in calcium currents. In the presence of the N-type calcium channel antagonist ω-conotoxin GVIA, the P-type calcium channel antagonist ω-Aga IVA, and ω-Aga MVIIC applied subsequent to the other toxins, the effect of Dyn A to reduce calcium currents was inhibited by 52, 28, and 16%, respectively. The L channel antagonist nifedipine did not affect the ability of Dyn A to inhibit calcium currents. These results suggest that in rat DRG neurons coupling of κ-opioid receptors to multiple transient, high-threshold calcium currents involves the Goα subclass of G proteins.

APA, Harvard, Vancouver, ISO, and other styles

20

Sever, Sanja, Hanna Damke, and Sandra L. Schmid. "Dynamin:Gtp Controls the Formation of Constricted Coated Pits, the Rate Limiting Step in Clathrin-Mediated Endocytosis." Journal of Cell Biology 150, no. 5 (September 4, 2000): 1137–48. http://dx.doi.org/10.1083/jcb.150.5.1137.

Full text

Abstract:

The GTPase dynamin is essential for receptor-mediated endocytosis, but its function remains controversial. A domain of dynamin, termed the GTPase effector domain (GED), controls dynamin's high stimulated rates of GTP hydrolysis by functioning as an assembly-dependent GAP. Dyn(K694A) and dyn(R725A) carry point mutations within GED resulting in reduced assembly stimulated GTPase activity. Biotinylated transferrin is more rapidly sequestered from avidin in cells transiently overexpressing either of these two activating mutants (Sever, S., A.B. Muhlberg, and S.L. Schmid. 1999. Nature. 398:481–486), suggesting that early events in receptor-mediated endocytosis are accelerated. Using stage-specific assays and morphological analyses of stably transformed cells, we have identified which events in clathrin-coated vesicle formation are accelerated by the overexpression of dyn(K694A) and dyn(R725A). Both mutants accelerate the formation of constricted coated pits, which we identify as the rate limiting step in endocytosis. Surprisingly, overexpression of dyn(R725A), whose primary defect is in stimulated GTP hydrolysis, but not dyn(K694A), whose primary defect is in self-assembly, inhibited membrane fission leading to coated vesicle release. Together, our data support a model in which dynamin functions like a classical GTPase as a key regulator of clathrin-mediated endocytosis.

APA, Harvard, Vancouver, ISO, and other styles

21

Bernatchez, Pascal N., Arpeeta Sharma, Pinar Kodaman, and William C. Sessa. "Myoferlin is critical for endocytosis in endothelial cells." American Journal of Physiology-Cell Physiology 297, no. 3 (September 2009): C484—C492. http://dx.doi.org/10.1152/ajpcell.00498.2008.

Full text

Abstract:

Myoferlin is a member of the ferlin family of proteins that promotes endomembrane fusion with the plasma membrane in muscle cells and endothelial cells. In addition, myoferlin is necessary for the surface expression of vascular endothelial growth factor receptor 2 through the formation of a protein complex with dynamin-2 (Dyn-2). Since Dyn-2 is necessary for the fission of endocytic vesicles from the plasma membrane, we tested the hypothesis that myoferlin may regulates aspects of receptor-dependent endocytosis. Here we show that myoferlin gene silencing decreases both clathrin and caveolae/raft-dependent endocytosis, whereas ectopic myoferlin expression in COS-7 cells increases endocytosis by up to 125%. Interestingly, we have observed that inhibition of Dyn-2 activity or caveolin-1 (Cav-1) expression impairs endocytosis as well as membrane resealing after injury, indicating that Dyn-2 and Cav-1 also participate in both membrane fission and fusion processes. Mechanistically, myoferlin partially colocalizes with Dyn-2 and Cav-1 and forms a protein complex with Cav-1 solubilized from tissue extracts. Together, these data describe a new role for myoferlin in receptor-dependent endocytosis and an overlapping role for myoferlin-Dyn-2-Cav-1 protein complexes in membrane fusion and fission events.

APA, Harvard, Vancouver, ISO, and other styles

22

Feuerstein, G., C. J. Molineaux, J. G. Rosenberger, R. L. Zerbe, B. M. Cox, and A. I. Faden. "Hemorrhagic shock and the central vasopressin and opioid peptide system of rats." American Journal of Physiology-Endocrinology and Metabolism 249, no. 3 (September 1, 1985): E244—E250. http://dx.doi.org/10.1152/ajpendo.1985.249.3.e244.

Full text

Abstract:

The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat. At 24 h after hemorrhage, the neurointermediate lobe (NIL) showed a reduction in Dyn A-IR (52%) and AVP-IR (32%) and an increase in LE-IR (72%); at this time, the anterior lobe also showed decreased Dyn A-IR (50%) and increased LE-IR (210%). Dyn A-IR, but not LE-IR, was also significantly depleted in some forebrain nuclei in all experimental groups as compared with intact controls, whereas Dyn A-IR in the hypothalamic ventromedial nucleus was elevated only in the sham-control rats. AVP-IR was elevated in the supraoptic nucleus and median eminence (200 and 31%, respectively) 2 and 24 h after bleeding, although plasma AVP returned to normal levels. These data indicate that stress and hypovolemic hypotension produce site and time-dependent change in distribution of dynorphins, AVP, and LE in the central nervous system.

APA, Harvard, Vancouver, ISO, and other styles

23

Hsieh, H. J., N. Q. Li, and J. A. Frangos. "Shear stress increases endothelial platelet-derived growth factor mRNA levels." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 2 (February 1, 1991): H642—H646. http://dx.doi.org/10.1152/ajpheart.1991.260.2.h642.

Full text

Abstract:

We have investigated the effect of shear stress on platelet-derived growth factor (PDGF) A and B chain mRNA levels in cultured human umbilical vein endothelial cells (hUVEC). The levels of both PDGF A and B mRNA in hUVEC were increased by a physiological shear stress (16 dyn/cm2), reaching a maximum approximately 1.5-2 h after the onset of shear stress and returning almost to control values at 4 h. The peak levels showed a more than 10-fold enhancement for PDGF A mRNA and a 2- to 3-fold increase for PDGF B mRNA (P less than 0.05). PDGF A mRNA also showed a shear-dependent increase from 0 to 6 dyn/cm2 (P less than 0.05) and then plateaued from 6 to 51 dyn/cm2. PDGF B mRNA levels were elevated as shear stress increased from 0 to 6 dyn/cm2 then declined gradually to a minimum at 31 dyn/cm2 (P less than 0.05) and increased again when shear stress rose to 51 dyn/cm2 (P less than 0.05). PDGF, a potent smooth muscle cell mitogen and vasoconstrictor, released from the endothelium may regulate the blood flow in vivo. The shear stress-dependent elevation of PDGF A and B mRNA in endothelial cells may be involved in the adaptation of blood vessels to flow mediated by the endothelium.

APA, Harvard, Vancouver, ISO, and other styles

24

Christiansen, P., E. Haslum, and E. Stenlund. "How to extract physics from ν dyn." Physics of Atomic Nuclei 75, no. 6 (June 2012): 744–47. http://dx.doi.org/10.1134/s1063778812060087.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Cornbleet, P. Joanne, David Myrick, Shelley Judkins, and Richard Levy. "Evaluation of the CELL-DYN 3000 Differential." American Journal of Clinical Pathology 98, no. 6 (December 1, 1992): 603–14. http://dx.doi.org/10.1093/ajcp/98.6.603.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Goossens, W., C. S. Scott, A. Walsh, L. Van Hove, and A. Van Orshoven. "Première évaluation clinique du Cell-Dyn 4000." Revue Française des Laboratoires 1997, no. 292 (April 1997): 149–51. http://dx.doi.org/10.1016/s0338-9898(97)80065-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

FLANAGAN, P., A. M. LANE, A. DELAMARE, C. J. BRIGGS, and D. A. McCARTHY. "An evaluation of the Cell-Dyn 1000." Clinical & Laboratory Haematology 9, no. 3 (September 1987): 313–20. http://dx.doi.org/10.1111/j.1365-2257.1987.tb00096.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Greenstein, Shane. "The Aftermath of the Dyn DDOS Attack." IEEE Micro 39, no. 4 (July 1, 2019): 66–68. http://dx.doi.org/10.1109/mm.2019.2919886.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Patnaik, Sushant, and Neil Immerman. "Dyn-FO: A Parallel, Dynamic Complexity Class." Journal of Computer and System Sciences 55, no. 2 (October 1997): 199–209. http://dx.doi.org/10.1006/jcss.1997.1520.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Hernandez, P., P. Navalesi, F. Maltais, A. Gursahaney, and S. B. Gottfried. "Comparison of static and dynamic measurements of intrinsic PEEP in anesthetized cats." Journal of Applied Physiology 76, no. 6 (June 1, 1994): 2437–42. http://dx.doi.org/10.1152/jappl.1994.76.6.2437.

Full text

Abstract:

Dynamic measurements of intrinsic positive end-expiratory pressure (PEEPi,dyn) considerably underestimate values obtained under static conditions (PEEPi,stat) in patients with severe airway obstruction. This may be related to regional differences in respiratory system mechanical properties and/or viscoelastic behavior. To evaluate this concept, PEEPi,stat and PEEPi,dyn were compared in six anesthetized paralyzed cats during dynamic hyperinflation produced by inverse ratio ventilation (IRV) and aerosolized methacholine (MCh). PEEPi,stat did not differ between IRV and MCh, averaging 2.70 +/- 0.33 (SE) and 2.70 +/- 0.25 cmH2O, respectively. PEEPi,dyn was significantly less with MCh (0.25 +/- 0.05 cmH2O) than IRV (2.05 +/- 0.28 cmH2O) (P < 0.0001), resulting in a lower PEEPi,dyn/PEEPi,stat ratio for MCh (0.10 +/- 0.02) than for IRV (0.76 +/- 0.03) (P < 0.0001). Compared with control values (33.5 +/- 3.7 cmH2O.l-1.s), maximum resistance (Rmax) was unchanged during IRV (29.1 +/- 2.1 cmH2O.l-1.s) but increased considerably with MCh (288.8 +/- 18.4 cmH2O.l-1.s) (P < 0.0001). Similar changes in minimum resistance (Rmin) and delta R (Rmax-Rmin) were noted. There was a strong inverse relationship between delta P, an index of time constant inequalities and viscoelastic pressure losses and PEEPi,dyn/PEEPi,stat ratio. No correlation was found between this ratio and Rmax, Rmin, delta R, or compliance. In conclusion, PEEPi,dyn considerably underestimates PEEPi,stat in acute nonhomogeneous airway obstruction with MCh in contrast to IRV, where the magnitude and distribution of mechanical properties remain unaltered. These findings support the concept that the difference between PEEPi,dyn and PEEPi,stat is related to regional time constant inequalities and/or increased viscoelastic pressure losses.

APA, Harvard, Vancouver, ISO, and other styles

31

Paramahita, Putu Amrita, I. Gusti Ayu Sri Dhyanaputri, and I. Wayan Karta. "Gambaran Kadar Hemoglobin Pada Ojek Motor Online (Go-Jek) Di Kantor Go-Jek Teuku Umar Barat Denpasar." JURNAL SKALA HUSADA : THE JOURNAL OF HEALTH 17, no. 1 (June 30, 2020): 24–32. http://dx.doi.org/10.33992/jsh:tjoh.v17i1.2056.

Full text

Abstract:

ABSTRACTMotorcycle drivers have a high risk of exposure from motor vehicle exhaust such as sulfur dioxide (SO2), carbon monoxide (CO) and nitrogen dioxide (NO2). Exhaust from vehicle exhaust can affect the concentration of hemoglobin especially carbon monoxide can increase the concentration of hemoglobin. In addition to motor vehicle fumes, hemoglobin levels are also affected by age, sex, smoking habits, pregnancy, malnutrition (iron, folate, vitamin B12, vitamin A), acute and chronic inflammation, parasitic infections and congenital diseases. Purposed: describe the hemoglobin of Gojek drivers at Office West Teuku Umar, Denpasar. Method: used descriptive by flow cytometry method used automatic analyzer CELL-DYN Ruby.Total respondents were 30 persons taken by accidental sampling meeting the inclusion criteria. In this study. Result: used descriptive by flow cytometry method used automatic analyzer CELL-DYN Ruby.Total respondents were 30 persons taken by accidental sampling meeting the inclusion criteria. In this study. Conclusion: of this research is that most hemoglobin cycle of gojek motorcycle is normal and all drivers do healthy life behavior by using mask and cleanse themselves after finished work. ABSTRAKPengemudi sepeda motor memiliki risiko tinggi terpapar gas buang kendaraan bermotor seperti sulfur dioksida (SO2), karbon monoksida (CO) dan nitrogen dioksida (NO2). Knalpot dari knalpot kendaraan dapat mempengaruhi konsentrasi hemoglobin terutama karbon monoksida yang dapat meningkatkan konsentrasi hemoglobin. Selain asap kendaraan bermotor, kadar hemoglobin juga dipengaruhi oleh usia, jenis kelamin, kebiasaan merokok, kehamilan, malnutrisi (zat besi, folat, vitamin B12, vitamin A), peradangan akut dan kronis, infeksi parasit dan penyakit bawaan. Tujuan: mendeskripsikan hemoglobin driver Gojek di Kantor Teuku Umar Barat Denpasar. Metode: menggunakan metode deskriptif dengan metode flow cytometry menggunakan automatic analyzer CELL-DYN Ruby.Jumlah responden sebanyak 30 orang yang diambil secara accidental sampling memenuhi kriteria inklusi. Dalam studi ini. Hasil: Digunakan deskriptif dengan metode flow cytometry menggunakan automatic analyzer CELL-DYN Ruby. Jumlah responden sebanyak 30 orang yang diambil secara accidental sampling memenuhi kriteria inklusi. Dalam studi ini. Kesimpulan: dari penelitian ini sebagian besar siklus hemoglobin sepeda motor gojek adalah normal dan semua pengemudi melakukan perilaku hidup sehat dengan menggunakan masker dan membersihkan diri setelah selesai bekerja.

APA, Harvard, Vancouver, ISO, and other styles

32

Vindis-Jesic, Marija, Jadranka Dejanovic, Nadica Cemerlic-Adjic, and Robert Jung. "Wall stress in ischemic heart disease." Medical review 55, no. 3-4 (2002): 125–28. http://dx.doi.org/10.2298/mpns0204125v.

Full text

Abstract:

Introduction Wall stress or wall tension is a conception derived from physics (Laplace's law) and represents the systolic force or work per surface unit. It is the systolic force made by myocardial tissues. Stress increase indicates enlargement of the left ventricle or increase of intracavitary pressure. Material and methods This investigation included 170 subjects; control group consisted of 50 patients (pts) with normal coronary angiographic finding without valvular anomalies and the examination group included 120 pts with coronary disease. Transthoracic echocardiography was performed in the left lateral position using computerized Hewlett Packard Sonos 1000 apparatus. Invasive hemodynamic procedure was performed using General Electrics CGR 300. Meridional and equatorial systolic and diastolic stress were calculated according to Grossman formula. Results The meridional end-diastolic equatorial stress was 18.55(12.12 dyn/cm2 x 10? in the control group, while in coronary patients it was 28.15?13.42 dyn/cm2 x 10?. In healthy persons the meridional end-systolic stress established by echocardiography was 190.37?23.15 dyn/cm2 x 10?, while in coronary patients 203.82?17.88 dyn/cm2 x 10?. End-diastolic equatorial stress was 34.32?17.18 dyn/cm2 x 10? in the control group and 46.13(17.82 dyn/cm2 x 10? in coronary patients. Systolic equatorial stress in the control group was 357.42(32.15 dyn/cm2 x 10? and in coronary patients 385.34(35.72 dyn/cm2 x 10?. The same parameters determined by invasive hemodynamic procedure were slightly higher, but without statistical significance in relation to the values determined by echocardiography (P>0.05). Conclusion Values equatorial and particulary meridional stress were higher in coronary patients in relations to healthy persons, but without significant difference. The correlation coefficients of all investigated parameters established by noninvasive 2D echocardiography and invasive hemodynamic procedure were in one domain of medium high values. meridional stress increases in coronary patients equatorial in hypertensive patients or valvular anomalies with severe myocardial hypertrophy. In regard to high correlation between these two techniques, echocardiography may be considered a highly reliable method in evaluation of wall tension.

APA, Harvard, Vancouver, ISO, and other styles

33

Sporea, Ioan, Raluca Lupușoru, Ruxandra Mare, Alina Popescu, Liana Gheorghe, Speranța Iacob, and Roxana Șirli. "Dynamics of Liver Stiffness Values by means of Transient Elastography in Patients with HCV Liver Cirrhosis undergoing Interferon Free Treatment." Journal of Gastrointestinal and Liver Diseases 26, no. 2 (June 1, 2017): 145–50. http://dx.doi.org/10.15403/jgld.2014.1121.262.dyn.

Full text

Abstract:

Background & Aims: Liver stiffness (LS) measurement by Transient Elastography (TE) has been widely accepted as a tool for fibrosis assessment. The aim of this study was to assess LS dynamics in a group of patients with HCV liver cirrhosis after interferon free treatment (IFT).Methods: This two-center clinical trial included 225 patients with compensated HCV cirrhosis (all genotype 1b), who received IFT for 12 weeks. All patients were evaluated by means of TE at the beginning and at the end of treatment (EOT), and a subgroup (170 patients) also 12 weeks after EOT; all of them had sustained viral response (SVR). Reliable LS measurements (LSM) were defined as a median value of 10 valid LSM, with IQR <30% and SR ≥60%. Both M and XL probes were used. For diagnosing cirrhosis we used a cut-off value of 12kPa as proposed by the Tsochatzis meta-analysis. We considered a decrease or increase of more than 10% in LSM as being significant.Results: Out of 225 subjects, reliable measurements were obtained in 93.7%, so that the final analysis included 211 patients. The mean LS values decreased significantly after IFT: 26.4±11.7 vs. 23.5±13.3 kPa (p=0.01). Most patients, 59.2% (125/211) presented more than 10% decrease in LS values, 24.1% (51/211) had stable LS values, while in 16.4% (35/211) cases, the LS values increased. In the subgroup of 170 patients with LSM also performed 12 weeks after EOT (SVR), the mean LS values were significantly lower as compared to baseline: 21.3±11 kPa vs. 27.4±11.9 kPa (p<0.0001) and also as compared to EOT: 21.3±11 kPa vs. 23.7±13.3 kPa (p<0.0001).Conclusion: In our patients with HCV liver cirrhosis, the mean LS values evaluated by TE significantly decreased after antiviral treatment at EOT and also 12 weeks after EOT as compared to baseline. Overall, about 60% of patients had LS values at EOT lower than at baseline, while 12 weeks after EOT about 75% of patients had LS values lower than at baseline. –.Abbreviations: APRI: aspartate aminotransferase platelet ratio index; BMI: body mass index; DAA: direct acting agents; EOT: end of treatment; FIB-4: fibrosis 4; HBV: hepatitis B virus; HCV: hepatitis C virus; IFT: interferon free treatment; IQR: interquartile range; LS: liver stiffness; LSM: liver stiffness measurements; SR: success rate; SVR: sustained viral response; TE: Transient Elastography.

APA, Harvard, Vancouver, ISO, and other styles

34

Dynel, Marta. "Theoretically on Mock Politeness in English and Italian." Journal of Language Aggression and Conflict 6, no. 1 (July 2, 2018): 149–65. http://dx.doi.org/10.1075/jlac.00007.dyn.

Full text

Abstract:

Abstract This essay offers insights into the problematic notions of irony, sarcasm and mock politeness, inspired by Charlotte Taylor’s recent monograph Mock Politeness in English and Italian. A Corpus-Assisted Metalanguage Analysis. Different understandings of the concept of mock politeness, as well as sarcasm and irony, are succinctly depicted. Some explanation is also provided for the contradictory findings reported in previous scholarship with regard to the im/politeness effects of irony. Additionally, this paper revisits Taylor’s select conclusions about the use of the first-order labels that she considers pertinent to mock politeness (i.e. labels used by lay language users).

APA, Harvard, Vancouver, ISO, and other styles

35

Dynel, Marta, and Fabio I. M. Poppi. "Arcana imperii*." Journal of Language Aggression and Conflict 8, no. 1 (October 25, 2019): 57–87. http://dx.doi.org/10.1075/jlac.00031.dyn.

Full text

Abstract:

Abstract This paper reports the findings of a study on the mechanics of insult-retort adjacency pairs in Twitter interactions. The analysis concerns primarily the humorous retorts made by the pornographic entrepreneur Stormy Daniels, who has been pelted with politically-loaded misogynist insults, many of which qualify as slut-shaming. These acts of verbal aggression are the result of her involvement in a legal dispute with President Donald Trump and his former attorney. Based on a carefully collected corpus of public exchanges of tweets, our qualitative analysis achieves a few goals. First, it brings to focus a previously ignored function of witty and creative humour, including the self-deprecating variety, as a powerful rhetorical strategy that helps address insults with dignity and that displays the speaker’s intellectual superiority over the attacker and a good sense of humour, as evidenced by multiple users’ positive metapragmatic evaluations of Stormy Daniels’s retorts. Second, these findings carry vital practical implications for handling misogynist comments, including slut-shaming, online. Third, this study offers new insights into the workings of insults and retorts thereto, not only in multi-party interactions on social media, specifically on Twitter, but also through traditional channels of communication.

APA, Harvard, Vancouver, ISO, and other styles

36

Dynel, Marta. "Taking cognisance of cognitive linguistic research on humour." Review of Cognitive Linguistics 16, no. 1 (May 31, 2018): 1–18. http://dx.doi.org/10.1075/rcl.00001.dyn.

Full text

Abstract:

Abstract This article is meant to give a state-of-the-art picture of cognitive linguistic studies on humour. Cognitive linguistics has had an immense impact on the development of humour research and, importantly, humour theory over the past few decades. On the one hand, linguists, philosophers and psychologists working in the field of humour research have put forward proposals to explain the cognitive processes underlying specifically humour production and reception (e.g. the incongruity-resolution framework and its refinements). On the other hand, humour research has drawn on theories and concepts advanced in contemporary cognitive linguistics taken as a whole (e.g. mental spaces, conceptual blending, salience or conceptual metaphor). The different notions and approaches originating in these strands of research are in various ways interwoven in order to give new insights into the cognitive workings of humour.

APA, Harvard, Vancouver, ISO, and other styles

37

Rohani, Esti, and J. Nugraha. "HUBUNGAN ANTARA FLAGGING ATYPDEP DI ALAT CELL-DYN 3200 DAN KEBERADAAN PLASMODIUM Spp DI DALAM DARAH PENDERITA DI RSUD DR.SOETOMO SURABAYA." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 17, no. 2 (March 17, 2018): 97. http://dx.doi.org/10.24293/ijcpml.v17i2.1022.

Full text

Abstract:

Malaria is a parasitic disease worldwide with a high morbidity and mortality. A rapid and accurate methods is needed to detectthe presence of malaria parasites in blood. A flagging system atypical depolarization (atypdep) on CBC result from Cell-Dyn 3200instrument has been related with malaria infection. An observational cross sectional approach with a total of 48 samples were obtainedfrom inpatients in the Dr. Soetomo Hospital Surabaya. Samples were screened with Cell-Dyn 3200 analyzer for CBC found atypdepflagging. The positive samples were later confirmed by microscopic to detect malaria parasites. From 48 samples with atypdep flagging,seven samples were positive of malaria in peripheral blood smear (13.1%). Most frequent atypdep flagging was seen in malignant disease(18.7), an approximately 54.6% of the sample is not accompanied by symptoms of fever. Lekositosis and anemia were found in each of20 samples (41.6%) and thrombocytopenia in 33.3% of the samples. The presence of atypdep flagging does not necessarily indicate theexistence of malaria infection or it could be said that atypdep flagging is not always associated with the presence of malaria infection.The usage of an atypdep flagging on Cell-Dyn instrument in non-endemic areas such as Surabaya is just an alert sign to evaluate themalaria infection rather than a screening method to detect malaria.

APA, Harvard, Vancouver, ISO, and other styles

38

Khan, Shaista, Bushra Ali, Anuj Chandra, and Shakeel Ahmad. "Event-by-Event Particle Ratio Fluctuations at LHC Energies." Advances in High Energy Physics 2021 (October 12, 2021): 1–14. http://dx.doi.org/10.1155/2021/6663846.

Full text

Abstract:

A Monte Carlo study of identified particle ratio fluctuations at LHC energies is carried out in the framework of HIJING model using the fluctuation variable ν dyn . The simulated events for Pb-Pb collisions at s N N = 2.76 and 5.02 TeV and Xe-Xe collisions at s N N = 5.44 TeV are analyzed. From this study, it is observed that the values of π , K , p , K , and π , p follow the similar trends of energy dependence as observed in the most central collision data by NA49, STAR, and ALICE experiments. It is also observed that ν dyn for all the three combinations of particles for semicentral and central collisions, the model predicted values of ν dyn A , B for Pb-Pb collisions at s N N = 2.76 TeV agree fairly well with those observed in the ALICE experiment. For peripheral collisions, however, the model predicted values of ν dyn π , K are somewhat smaller, whereas for p , K and π , p it predicts larger values as compared to the corresponding experimental values. The possible reasons for the observed differences are discussed. The ν dyn values scaled with charged particle density when plotted against N part exhibit a flat behaviour, as expected from the independent particle emission sources. For p , K and π , p combinations, a departure from the flat trend is, however, observed in central collisions in the case of low p T window when the effect of jet quenching or resonances is considered. Furthermore, the study of ν dyn A , B dependence on particle density for various collision systems (including proton-proton collisions) suggests that at LHC energies ν dyn values for a given particle pair are simply a function of charged particle density, irrespective of system size, beam energy, and collision centrality.

APA, Harvard, Vancouver, ISO, and other styles

39

Sainsbury, Amanda, Shu Lin, Keely McNamara, Katy Slack, Ronaldo Enriquez, Nicola J. Lee, Dana Boey, et al. "Dynorphin Knockout Reduces Fat Mass and Increases Weight Loss during Fasting in Mice." Molecular Endocrinology 21, no. 7 (July 1, 2007): 1722–35. http://dx.doi.org/10.1210/me.2006-0367.

Full text

Abstract:

Abstract Endogenous opioids, particularly dynorphins, have been implicated in regulation of energy balance, but it is not known how they mediate this in vivo. We investigated energy homeostasis in dynorphin knockout mice (Dyn−/− mice) and probed the interactions between dynorphins and the neuropeptide Y (NPY) system. Dyn−/− mice were no different from wild types with regards to body weight and basal and fasting-induced food intake, but fecal output was increased, suggesting decreased nutrient absorption, and they had significantly less white fat and lost more weight during a 24-h fast. The neuroendocrine and thermal responses to fasting were at least as pronounced in Dyn−/− as in wild types, and there was no stimulatory effect of dynorphin knockout on 24-h energy expenditure (kilocalories of heat produced) or physical activity. However, Dyn−/− mice showed increased circulating concentrations of 3,4-dihydroxyphenlacetic acid and 3,4-dihydroxyphenylglycol, suggesting increased activity of the sympathetic nervous system. The respiratory exchange ratio of male but not female Dyn−/− mice was reduced, demonstrating increased fat oxidation. Interestingly, expression of the orexigenic acting NPY in the hypothalamic arcuate nucleus was reduced in Dyn−/− mice. However, fasting-induced increases in pre-prodynorphin expression in the arcuate nucleus, the paraventricular nucleus, and the ventromedial hypothalamus but not the lateral hypothalamus were abolished by deletion of Y1 but not Y2 receptors. Therefore, ablation of dynorphins results in increases in fatty acid oxidation in male mice, reductions in adiposity, and increased weight loss during fasting, possibly via increases in sympathetic activity, decreases in intestinal nutrient absorption, and interactions with the NPYergic system.

APA, Harvard, Vancouver, ISO, and other styles

40

Matt, Sarah E., Laura S. Johnson, Jeffrey W. Shupp, Tareq Kheirbek, and Jack A. Sava. "Management of Fasciotomy Wounds-Does the Dressing Matter?" American Surgeon 77, no. 12 (December 2011): 1656–60. http://dx.doi.org/10.1177/000313481107701238.

Full text

Abstract:

Fasciotomy is a limb-saving procedure in the management of ischemic extremities. Little evidence exists as to the best method of fasciotomy wound management. We hypothesized that the use of vacuum dressing (VAC) or creation of dynamic tension (DYN) would increase rates of primary closure, reducing the need for split thickness skin grafting (STSG). The records of a large urban Level I trauma center were used to identify fasciotomy recipients over a 10-year period and were retrospectively analyzed. Data collected included injury characteristics, wound management, and outcomes. Wound management was dictated by surgeon preference, and categorized as gauze packing, DYN, or VAC. The primary outcome was primary closure versus need for STSG. Wound management cohorts were compared using logistic regression. Fisher's exact test and χ2 were performed to compare proportions and categorical variables respectively. From 2000 to 2009, 227 patients had a fasciotomy performed. Mechanism, age, and incidence of fracture were different between the groups. There was a trend towards increased primary closure with DYN (83%). Average length of stay (LOS) was 21 days for those receiving primary closure and 27 days for STSG. There was a significant decrease in LOS for the DYN group (average 16 days) when compared with gauze packing and VAC. In this series of 227 patients who underwent fasciotomy, no technique of wound management produced a significant improvement in primary closure rate. A trend toward more primary closure was seen in the DYN group. LOS was longer for patients receiving STSG. The DYN cohort had a significantly shorter LOS.

APA, Harvard, Vancouver, ISO, and other styles

41

Niwiński, A. "Book Review: Untersuchungen zu den Totenbuch-Papyri der 18. Dyn. Kriterien ihrer Datierung." Journal of Egyptian Archaeology 77, no. 1 (October 1991): 212–15. http://dx.doi.org/10.1177/030751339107700136.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Balestra, P., C. Parisi, A. Alfonsi, and C. Rabiti. "Simulation of AER-DYN-002 and AER-DYN-003 Control Rod Ejection Benchmarks by RELAP5-3D/PHISICS Coupled Codes." Nuclear Technology 193, no. 1 (January 2016): 175–82. http://dx.doi.org/10.13182/nt14-138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Tian, Wende, Nan Liu, Dongwu Sui, Zhe Cui, Zijian Liu, Ji Wang, Hao Zou, and Ya Zhao. "Early Warning of Internal Leakage in Heat Exchanger Network Based on Dynamic Mechanism Model and Long Short-Term Memory Method." Processes 9, no. 2 (February 19, 2021): 378. http://dx.doi.org/10.3390/pr9020378.

Full text

Abstract:

In the process of butadiene rubber production, internal leakage occurs in heat exchangers due to excessive pressure difference. It leads to the considerable flow of organic matters into the circulating water system. Since these organic matters are volatile and prone to explode in the cold water tower, internal leakage is potentially dangerous for the enterprise. To prevent this phenomenon, a novel intelligent early warning and risk assessment method (DYN-EW-QRA) is proposed in this paper by combining dynamic simulations (DYN), long short-term memory (LSTM), and quantitative risk assessment (QRA). First, an original internal leakage mechanism model of a heat exchanger network is designed and simulated by DYN to obtain datasets. Second, the potential relationships between variables that have a direct impact on the hazards of the accident are deeply learned by LSTM to predict the internal leakage trends. Finally, the QRA method is used to analyze the range and destructive power of potential hazards. The results show that DYN-EW-QRA method has excellent performance.

APA, Harvard, Vancouver, ISO, and other styles

44

Sureshkumar, Keerthana, Julian Guo, Michelle Tran, Sagunya Malhotra, Syed Muzzammil Ahmad, and Kabirullah Lutfy. "The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol." Psychoactives 1, no. 2 (October 13, 2022): 46–63. http://dx.doi.org/10.3390/psychoactives1020006.

Full text

Abstract:

Alcohol use disorder (AUD) represents major public and socioeconomic issues. Alcohol exerts its pharmacological effects by altering different neurotransmitter systems, such as g-aminobutyric acid (GABA), glutamate, opioids, etc. Recent evidence suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system mediates the negative affective states associated with alcohol withdrawal. This system is also involved in stress-mediated alcohol intake in alcohol-dependent subjects. The DYN/KOR system probably exerts its action in the central nucleus of the amygdala (CeA) to mediate the negative affective states associated with alcohol withdrawal. This article aims to review the current literature regarding the role of the DYN/KOR system in the actions of alcohol. We first review the literature regarding the effect of alcohol on the level of the peptide and its receptor, and the role of the endogenous DYN/KOR system in alcohol reward and negative affective states associated with alcohol withdrawal is then discussed. We also review the literature regarding the effects of KOR ligands on these processes.

APA, Harvard, Vancouver, ISO, and other styles

45

Straatman, Caroline M. S., Arjen van der Wel, Josha van Houdt, Rachel Bezanson, Eric F. Bell, Pieter van Dokkum, Francesco D’Eugenio, et al. "LEGA-C: Analysis of Dynamical Masses from Ionized Gas and Stellar Kinematics at z ∼ 0.8." Astrophysical Journal 928, no. 2 (March 31, 2022): 126. http://dx.doi.org/10.3847/1538-4357/ac4e18.

Full text

Abstract:

Abstract We compare dynamical mass estimates based on spatially extended stellar and ionized gas kinematics (M dyn,* and M dyn,eml, respectively) of 157 star-forming galaxies at 0.6 ≤ z < 1. Compared with z ∼ 0, these galaxies have enhanced star formation rates, with stellar feedback likely affecting the dynamics of the gas. We use LEGA-C DR3, the highest-redshift data set that provides sufficiently deep measurements of a K s -band limited sample. For M dyn,*, we use Jeans anisotropic multi-Gaussian expansion models. For M dyn,eml, we first fit a custom model of a rotating exponential disk with uniform dispersion, whose light is projected through a slit and corrected for beam smearing. We then apply an asymmetric drift correction based on assumptions common in the literature to the fitted kinematic components to obtain the circular velocity, assuming hydrostatic equilibrium. Within the half-light radius, M dyn,eml is on average lower than M dyn,*, with a mean offset of –0.15 ± 0.016 dex and galaxy-to-galaxy scatter of 0.19 dex, reflecting the combined random uncertainty. While data of higher spatial resolution are needed to understand this small offset, it supports the assumption that the galaxy-wide ionized gas kinematics do not predominantly originate from disruptive events such as star formation–driven outflows. However, a similar agreement can be obtained without modeling from the integrated emission line dispersions for axis ratios q < 0.8. This suggests that our current understanding of gas kinematics is not sufficient to efficiently apply asymmetric drift corrections to improve dynamical mass estimates compared with observations lacking the signal-to-noise ratio required for spatially extended dynamics.

APA, Harvard, Vancouver, ISO, and other styles

46

Venteicher, Andrew, and William M. Armstead. "Vasopressin contributes to dynorphin modulation of hypoxic cerebrovasodilation." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 6 (December 1, 1998): H2072—H2079. http://dx.doi.org/10.1152/ajpheart.1998.275.6.h2072.

Full text

Abstract:

Because pial artery dilation during a 20- or 40-min hypoxic exposure was less than that observed during a 5- or 10-min exposure, stimulus duration determines the vascular response to hypoxia. Dynorphin (Dyn) modulates hypoxic pial dilation and contributes to decremented dilation during longer hypoxic exposures. This study was designed to determine whether vasopressin (VP) contributes to Dyn modulation of hypoxic pial dilation in newborn pigs equipped with a closed cranial window. Moderate (M) and severe (S) hypoxia (arterial [Formula: see text] ∼ 35 and 25 mmHg, respectively) had no effect on cerebrospinal fluid VP during a 5-min exposure but increased its concentration during longer exposure periods. The VP antagonist [β-mercapto-β,β-cyclopentamethylenepropionyl1, O-Me-Tyr2,Arg8]vasopressin (MEAVP) had no influence on pial dilation during the 5-min exposure but potentiated the 20- and 40-min M and S hypoxic exposure dilations: 21 ± 2 vs. 29 ± 3% and 23 ± 2 vs. 33 ± 2% for 20- and 40-min S hypoxic dilation before and after MEAVP. Topical VP during 5 min of hypoxia elicited dilation that was reversed to vasoconstriction during 20 min of S and 40 min of M and S hypoxia. Similarly, during 5 min of hypoxia, Dyn elicited dilation that was reversed to vasoconstriction during longer hypoxic periods. MEAVP blunted this Dyn-induced vasoconstriction. These data show that VP modulates hypoxic pial dilation in a stimulus duration-dependent manner and that VP contributes to the reversal of Dyn from a dilator to a constrictor during prolonged hypoxia. Finally, these data suggest that VP contributes to Dyn modulation of hypoxic cerebrovasodilation.

APA, Harvard, Vancouver, ISO, and other styles

47

Cho, Sung Ki, Sang-Kwon Lee, Eun-Young Choi, and Jin-Mok Hur. "The Evaluation of Polarized Dynamic Reference Electrode (p-Dyn RE) for LiCl-1 wt% Li2O Molten Salt at 650°C: Li+/Li p-Dyn RE versus O2/O2−p-Dyn RE." Journal of The Electrochemical Society 163, no. 10 (2016): E308—E312. http://dx.doi.org/10.1149/2.1061610jes.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Conway, Daniel E., Marcie R. Williams, Suzanne G. Eskin, and Larry V. McIntire. "Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 2 (February 2010): H367—H374. http://dx.doi.org/10.1152/ajpheart.00565.2009.

Full text

Abstract:

To simulate the effects of shear stress in regions of the vasculature prone to developing atherosclerosis, we subjected human umbilical vein endothelial cells to reversing shear stress to mimic the hemodynamic conditions at the wall of the carotid sinus, a site of complex, reversing blood flow and commonly observed atherosclerosis. We compared the effects of reversing shear stress (time-average: 1 dyn/cm2, maximum: +11 dyn/cm2, minimum: −11 dyn/cm2, 1 Hz), arterial steady shear stress (15 dyn/cm2), and low steady shear stress (1 dyn/cm2) on gene expression, cell proliferation, and monocyte adhesiveness. Microarray analysis revealed that most differentially expressed genes were similarly regulated by all three shear stress regimens compared with static culture. Comparisons of the three shear stress regimens to each other identified 138 genes regulated by low average shear stress and 22 genes regulated by fluid reversal. Low average shear stress induced increased cell proliferation compared with high shear stress. Only reversing shear stress exposure induced monocyte adhesion. The adhesion of monocytes was partially inhibited by the incubation of endothelial cells with ICAM-1 blocking antibody. Increased heparan sulfate proteoglycan expression was observed on the surface of cells exposed to reversing shear stress. Heparinase III treatment significantly reduced monocyte adhesion. Our results suggest that low steady shear stress is the major impetus for differential gene expression and cell proliferation, whereas reversing flow regulates monocyte adhesion.

APA, Harvard, Vancouver, ISO, and other styles

49

Wajima, Zen'ichiro, Toshiya Shiga, Tatsusuke Yoshikawa, Akira Ogura, Kazuyuki Imanaga, Tetsuo Inoue, and Ryo Ogawa. "Effect of Prophylactic Bronchodilator Treatment with Intravenous Colforsin Daropate, a Water-soluble Forskolin Derivative, on Airway Resistance after Tracheal Intubation." Anesthesiology 99, no. 1 (July 1, 2003): 18–26. http://dx.doi.org/10.1097/00000542-200307000-00007.

Full text

Abstract:

Background After induction of anesthesia, lung resistance increases. The authors hypothesized that prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, before tracheal intubation would result in decreased lung resistance and increased lung compliance after tracheal intubation when compared with placebo medication. Methods Forty-six adult patients were randomized to placebo or colforsin daropate treatment. Patients in the control group received normal saline; patients in the colforsin group received 0.75 microg. kg-1 x min-1 colforsin daropate intravenously until the study ended. Thirty minutes after the study began, the authors administered 5 mg/kg thiamylal and 5 microg/kg fentanyl for induction of general anesthesia and 0.3 mg/kg vecuronium for muscle relaxation. A 15-mg. kg-1. h-1 continuous infusion of thiamylal followed anesthetic induction. Four, 8, 12, and 16 min after tracheal intubation, mean airway resistance (R(awm)), expiratory airway resistance (R(awe)), and dynamic lung compliance (C(dyn)) were measured. Results Patients in the colforsin group had significantly lower R(awm) and R(awe) and higher C(dyn) after intubation than those in the control group. Differences in R(awm), R(awe), and C(dyn) between the two groups persisted through the final measurement at 16 min. At 4 min after intubation, smokers had a higher R(awm) and a lower C(dyn) than nonsmokers in the control group. After treatment by intravenous colforsin daropate, R(awm), R(awe), and C(dyn) values were similar for smokers and nonsmokers after tracheal intubation. Conclusions Prophylactic treatment with colforsin daropate produced lower R(awm) and R(awe) and higher C(dyn) after tracheal intubation when compared with placebo medication. Pretreatment before intubation may be beneficial and advantageous for middle-aged smokers.

APA, Harvard, Vancouver, ISO, and other styles

50

Elia, Antonis, Matthew J. Barlow, Kevin Deighton, Oliver J. Wilson, and John P. O’Hara. "Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers." European Journal of Applied Physiology 119, no. 11-12 (September 28, 2019): 2557–65. http://dx.doi.org/10.1007/s00421-019-04235-1.

Full text

Abstract:

Abstract Purpose Serum erythropoietin (EPO) concentration is increased following static apnoea-induced hypoxia. However, the acute erythropoietic responses to a series of dynamic apnoeas in non-divers (ND) or elite breath-hold divers (EBHD) are unknown. Methods Participants were stratified into EBHD (n = 8), ND (n = 10) and control (n = 8) groups. On two separate occasions, EBHD and ND performed a series of five maximal dynamic apnoeas (DYN) or two sets of five maximal static apnoeas (STA). Control performed a static eupnoeic (STE) protocol to control against any effects of water immersion and diurnal variation on EPO. Peripheral oxygen saturation (SpO2) levels were monitored up to 30 s post each maximal effort. Blood samples were collected at 30, 90, and 180 min after each protocol for EPO, haemoglobin and haematocrit concentrations. Results No between group differences were observed at baseline (p > 0.05). For EBHD and ND, mean end-apnoea SpO2 was lower in DYN (EBHD, 62 ± 10%, p = 0.024; ND, 85 ± 6%; p = 0.020) than STA (EBHD, 76 ± 7%; ND, 96 ± 1%) and control (98 ± 1%) protocols. EBHD attained lower end-apnoeic SpO2 during DYN and STA than ND (p < 0.001). Serum EPO increased from baseline following the DYN protocol in EBHD only (EBHD, p < 0.001; ND, p = 0.622). EBHD EPO increased from baseline (6.85 ± 0.9mlU/mL) by 60% at 30 min (10.82 ± 2.5mlU/mL, p = 0.017) and 63% at 180 min (10.87 ± 2.1mlU/mL, p = 0.024). Serum EPO did not change after the STA (EBHD, p = 0.534; ND, p = 0.850) and STE (p = 0.056) protocols. There was a significant negative correlation (r = − 0.49, p = 0.003) between end-apnoeic SpO2 and peak post-apnoeic serum EPO concentrations. Conclusions The novel findings demonstrate that circulating EPO is only increased after DYN in EBHD. This may relate to the greater hypoxemia achieved by EBHD during the DYN.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'DyN'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles