Journal articles on the topic 'Dual timeline'
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Yen, Pei-Chun, Willy Chou, Tsair-Wei Chien, and Tung-Hui Jen. "Analyzing fulminant myocarditis research trends and characteristics using the follower-leading clustering algorithm (FLCA): A bibliometric study." Medicine 102, no. 26 (June 30, 2023): e34169. http://dx.doi.org/10.1097/md.0000000000034169.
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Background: Myocarditis can be classified into 2 categories: fulminant myocarditis (FM) and nonfulminant myocarditis. FM is the most severe type, characterized by its acute and explosive nature, posing a sudden and life-threatening risk with a high fatality rate. Limited research has been conducted on FM characteristics using cluster analysis. This study introduces the following-leading clustering algorithm (`) as a unique method and utilizes it to generate a dual map and timeline view of FM themes, aiming to gain a better understanding of FM. Methods: The metadata were obtained from the Web of Science (WoS) database using an advanced search strategy based on the topic (TS= ((“Fulminant”) AND (“Myocarditis”))). The analysis comprised 3 main components: descriptive analytics, which involved identifying the most influential entities using CJAL scores and analyzing publication trends, author collaborations using the FLCA algorithm, and generating a dual map and timeline view of FM themes using the FLCA algorithm. The visualizations included radar plots divided into 4 quadrants, stacked bar and line charts, network charts, chord diagrams, a dual map overlay, and a timeline view. Results: The findings reveal that the prominent entities in terms of countries, institutes, departments, and authors were the United States, Huazhong University of Science and Technology (China), Cardiology, and Enrico Ammirati from Italy. A dual map, based on the research category, was created to analyze the relationship between citing and cited articles. It showed that articles related to cells and clinical medicine/surgery were frequently cited by articles in the fields of general health/public/nursing and clinical medicine/surgery. Additionally, a visual timeline view was presented on Google Maps, showcasing the themes extracted from the top 100 cited articles. These visualizations were successfully and reliably generated using the FLCA algorithm, offering insights from various perspectives. Conclusion: A new FLCA algorithm was utilized to examine bibliometric data from 1989 to 2022, specifically focusing on FM. The results of this analysis can serve as a valuable guide for researchers, offering insights into the thematic trends and characteristics of FM research development. This, in turn, can facilitate and promote future research endeavors in this field.
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Eidenberger, Lukas, and Herta Steinkellner. "Engineering biopharmazeutischer Produkte in der Pflanzenbiotechnologie." BIOspektrum 29, no. 4 (June 2023): 418–20. http://dx.doi.org/10.1007/s12268-023-1949-0.
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AbstractPlants can be used to recombinantly produce high-quality biopharmaceuticals, such as therapeutic proteins and vaccines, also known as plant molecular farming (PMF). Recent advances in engineering places PMF amongst the most innovative manufacturing technologies that reduce cost and shorten the production timeline. State-of-the-art PMF uses a dual-approach strategy to optimize the generation of products, namely engineering of expression vectors and production hosts. Here we describe the assembly of genetic circuits, engineered to enable the rapid expression of multimeric proteins in the commonly used expression host Nicotiana benthamiana.
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Klassen, Sarah, Tiago Attorre, David Brotherson, Rachna Chhay, Wayne Johnson, Ian Moffat, and Roland Fletcher. "Deciphering a Timeline of Demise at Medieval Angkor, Cambodia Using Remote Sensing." Remote Sensing 13, no. 11 (May 27, 2021): 2094. http://dx.doi.org/10.3390/rs13112094.
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The Greater Angkor Region was the center of the Khmer Empire from the 9th until the 13th to the 14th centuries CE, when it entered a period of decline. Many studies have suggested that the decline of Angkor was precipitated by several factors, including severe monsoons, geopolitical shifts, and invasions. In this paper, we use light detection and ranging and ground penetrating radar to investigate the possible intersection of two of these existential threats in one feature: the North Bank Wall. Our results indicate that this feature was designed with dual functionality of extending the urban area’s defenses to the east of Angkor Thom while maintaining the existing infrastructure for the distribution and disposal of water. These findings suggest that the North Bank Wall was built before the severe droughts in the mid-13th century. The timing of the construction indicates that the perceived need for additional security—whether from internal factional disputes or external adversaries—predated the final adaptations to the hydraulic network during the unprecedented monsoon variability of the 14th century. These results indicate that perceived political unrest may have played a more important role in the decline of the site than previously known.
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Milovanović, Miloš, and Nicoletta Saulig. "The Duality of Psychological and Intrinsic Time in Artworks." Mathematics 12, no. 12 (June 14, 2024): 1850. http://dx.doi.org/10.3390/math12121850.
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The paper investigates the problem of the time arrow in terms of artistic creation. The statistical model of artwork signal processing is established in order to identify a duality relation between psychological and intrinsic time. The intrinsic time is linked to the time operator of wavelets, and the psychological one is metaphorically related to the spatial domain of an artwork. The increase of irreducible randomness along the timeline is formulated by the second law of thermodynamics. The dual statement concerns an increase in statistical complexity, which is the definition of self-organization. In that manner, two arrows of time which are opposed and dual to each other are recognized. The authors have indicated a link to the theory of musical forms, the originality issue, and the perspective problem. Some repercussions for art theory, neuroaesthetics, and psychophysics have also been implied.
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Piper, Megan E., Timothy B. Baker, Neal L. Benowitz, and Douglas E. Jorenby. "Changes in Use Patterns Over 1 Year Among Smokers and Dual Users of Combustible and Electronic Cigarettes." Nicotine & Tobacco Research 22, no. 5 (May 6, 2019): 672–80. http://dx.doi.org/10.1093/ntr/ntz065.
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Abstract Background Dual use of combustible and electronic cigarettes (e-cigarettes) is a growing use pattern; more than half of e-cigarette users are dual users. However, little is known regarding the course of dual use; for example, the likelihood of discontinuation of either combustible or e-cigarettes or both. Methods Adult daily smokers and dual users (daily smokers who also vaped at least once per week) who did not intend to quit use of either product in the next 30 days participated in a longitudinal, observational study (N = 322, 51.2% women, 62.7% white, mean age = 42.27 [SD = 14.05]). At baseline, participants completed demographics and smoking and vaping history assessments. They also reported daily cigarette and e-cigarette use via timeline follow-back assessment and provided a breath sample for carbon monoxide assay at 4-month intervals for 1 year. Results Of those who completed the year 1 follow-up, 1.9% baseline smokers and 8.0% dual users achieved biochemically confirmed seven-day point-prevalence abstinence from combustible cigarettes (χ2 = 4.57, p = .03). Of initial dual users, by 1 year 43.9% were smoking only, 48.8% continued dual use, 5.9% were vaping only, and 1.4% abstained from both products. Among baseline smokers, 92.3% continued as exclusive smokers. Baseline dual users who continued e-cigarette use were more likely to be white and report higher baseline e-cigarette dependence. Conclusions In this community sample, the majority of dual users transitioned to exclusive smoking. A higher percentage of dual users quit smoking than smokers, but attrition and baseline differences between the groups compromise strong conclusions. Sustained e-cigarette use was related to baseline e-cigarette dependence. Implications This research suggests that dual use of combustible and e-cigarettes is not a sustained pattern for the majority of dual users, but it is more likely to be a continued pattern if the user is more dependent on e-cigarettes. There was evidence that dual users were more likely to quit smoking than exclusive smokers, but this may be due to factors other than their dual use.
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Huerta, Daniel, and Mark Pyles. "A dual portfolio approach to a student managed fund." Managerial Finance 46, no. 5 (February 27, 2019): 675–84. http://dx.doi.org/10.1108/mf-08-2018-0394.
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Purpose The purpose of this paper is to describe an investment program that offers students with the opportunity to simultaneously manage a private asset fund and a public asset fund. The program has been in operation since 2013 and has made significant progress in student placement and connectivity with local, regional and national financial firms. Design/methodology/approach The authors describe the structure, methods used and challenges encountered in this dual portfolio environment and add relevant thoughts for discussion. The authors discuss potential conflicts of interests that may arise in managing a private equity portfolio, the concern of proper deal flow, the issue of the investment timeline when investing in private equity and the problems encountered when measuring private equity performance. Findings While public asset funds have been around for decades and are relatively well accepted throughout all levels and types of higher education institutions. The uses of private equity funds, though not unheard of, are much less prevalent. Allowing the same group of students to manage both type of portfolios is relatively unique and provides with a more comprehensive learning experience. Originality/value A primary distinguishing attribute of this program is that accepted students are given the opportunity to simultaneously manage both public and private equity assets throughout an academic year. The goal is to create a comprehensive portfolio management program that replicates a changing investment management environment where private equity is an increasingly significant asset class.
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Howell, David R., Anna N. Brilliant, and William P. Meehan. "Tandem Gait Test-Retest Reliability Among Healthy Child and Adolescent Athletes." Journal of Athletic Training 54, no. 12 (December 1, 2019): 1254–59. http://dx.doi.org/10.4085/1062-6050-525-18.
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Context The tandem gait test is a method for assessing dynamic postural control and part of the Sport Concussion Assessment Tool, versions 3 and 5. However, its reliability among child and adolescent athletes has yet to be established. Objective To examine the test-retest reliability of the single-task and dual-task tandem gait test among healthy child and adolescent athletes. Design Descriptive laboratory study. Setting Sports injury-prevention center. Patients or Other Participants Uninjured and healthy athletes between the ages of 9 and 18 years. Intervention(s) Tandem gait measures repeated 3 times across the period of approximately 1 month. Main Outcome Measure(s) Participants completed the tandem gait test under single-task and dual-task (ie, while simultaneously executing a cognitive task) conditions. Our primary outcome measure was completion time during the single-task and dual-task conditions. We also assessed cognitive accuracy and response rate while participants completed the dual-task tandem gait test. Results Thirty-two child and adolescent athletes completed the study (mean age = 14.3 ± 2.4 years; females = 16). Single-task tandem gait times were similar across the 3 testing sessions (14.4 ± 4.8, 13.5 ± 4.2, and 13.8 ± 4.8 seconds; P = .45). Dual-task tandem gait times steadily improved across the test timeline (18.6 ± 6.9, 16.6 ± 4.5, and 15.8 ± 4.7 seconds; P = .02). Bivariate correlations indicated moderately high to high agreement from test 1 to test 2 (single-task r = .627; dual-task r = 0.655) and from test 2 to test 3 (single-task r = 0.852; dual-task r = 0.775). Both the single-task (intraclass correlation coefficient; ICC [3,1] = 0.86; 95% confidence interval [CI] = 0.73, 0.93) and dual-task (ICC [3,1] = 0.84; 95% CI = 0.69, 0.92) conditions demonstrated high reliability across testing sessions. Conclusions Tandem gait outcome measures demonstrated high test-retest reliability in both the single- and dual-task conditions. The overall reliability was within the acceptable range for clinical practice, but improvements across tests suggested a moderate practice effect. Tandem gait represents a reliable, dynamic, postural-control test that requires minimal space, cost, and time.
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Khoshbin, Amir, Fares S. Haddad, Sarah Ward, S. O hEireamhoin, James Wu, Leo Nherera, and Amit Atrey. "A cost-effectiveness assessment of dual-mobility bearings in revision hip arthroplasty." Bone & Joint Journal 102-B, no. 9 (September 1, 2020): 1128–35. http://dx.doi.org/10.1302/0301-620x.102b9.bjj-2019-1742.r1.
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Aims The rate of dislocation when traditional single bearing implants are used in revision total hip arthroplasty (THA) has been reported to be between 8% and 10%. The use of dual mobility bearings can reduce this risk to between 0.5% and 2%. Dual mobility bearings are more expensive, and it is not clear if the additional clinical benefits constitute value for money for the payers. We aimed to estimate the cost-effectiveness of dual mobility compared with single bearings for patients undergoing revision THA. Methods We developed a Markov model to estimate the expected cost and benefits of dual mobility compared with single bearing implants in patients undergoing revision THA. The rates of revision and further revision were calculated from the National Joint Registry of England and Wales, while rates of transition from one health state to another were estimated from the literature, and the data were stratified by sex and age. Implant and healthcare costs were estimated from local procurement prices and national tariffs. Quality-adjusted life-years (QALYs) were calculated using published utility estimates for patients undergoing THA. Results At a minimum five-year follow-up, the use of dual mobility was cost-effective with an estimated incremental cost-effectiveness ratio (ICER) of between £3,006 and £18,745/QALY for patients aged < 55 years and between 64 and 75 years, respectively. For those aged > 75 years dual mobility was only cost-effective if the timeline was beyond seven years. The use of dual mobility bearings was cost-saving for patients aged < 75 years and cost-effective for those aged > 75 years if the time horizon was beyond ten years. Conclusion The use of dual mobility bearings is cost-effective compared with single bearings in patients undergoing revision THA. The younger the patient is, the more likely it is that a dual mobility bearing can be more cost-effective and even cost-saving. The results are affected by the time horizon and cost of bearings for those aged > 75 years. For patients aged > 75 years, the surgeon must decide whether the use of a dual mobility bearing is a viable economic and clinical option. Cite this article: Bone Joint J 2020;102-B(9):1128–1135.
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Reddy, Kumeshan, and Akshay Kumar Saha. "An Investigation into the Utilization of Swarm Intelligence for the Design of Dual Vector and Proportional–Resonant Controllers for Regulation of Doubly Fed Induction Generators Subject to Unbalanced Grid Voltages." Energies 15, no. 20 (October 11, 2022): 7476. http://dx.doi.org/10.3390/en15207476.
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This work presents an investigation into the use of swarm intelligence techniques for the control of the doubly fed induction generator under unbalanced grid voltages. Swarm intelligence is a concept that was introduced in the late 20th century but has since undergone constant evolution and modifications. Similarly, the doubly fed induction generator has recently come under intense investigation. Owing to the direct grid connection of the DFIG, an unbalanced grid voltage harshly impacts its output power. Established mitigation measures include the use of the dual vector and proportional–resonant control methods. This work investigates the effectiveness of utilizing swarm intelligence for the purpose of controller gain optimization. A comparison of the application of swarm intelligence to the dual vector and proportional–resonant controllers was carried out. Three swarm intelligence techniques from across the timeline were utilized including particle swarm optimization, the bat algorithm, and the gorilla troops optimization algorithm. The system was subject to single-phase voltage dips of 5% and 10%. The results indicate that modern swarm intelligence techniques are effective at optimizing controller gains. This shows that as swarm intelligence techniques evolve, they may be suitable for use in the optimization of controller gains for numerous applications.
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Rogova, E. N., and L. S. Yanitskiy. "Traditions of Magical Realism in M. Shishkin's <i>Letter Book</i> and N. Abgaryan's <i>Simon</i>." SibScript 25, no. 1 (March 16, 2023): 136–46. http://dx.doi.org/10.21603/sibscript-2023-25-1-136-146.
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The article describes the traditions of magical realism in M. Shishkin's Letter Book and N. Abgaryan's Simon. The research involved comparative, mytho-poetic, hermeneutic, formal, and structural methods. V. I. Tyupa's theory of artistic discourse and F. Schlegel's idea of irony served as the basic theory in identifying the motifs associated with magical realism and generated by the ironic type of artistic completion. The term of magical realism covers works that belong to very different literary movements. The authors used the ironic type of aesthetic completion to explain similar elements in different poetics of magical realism fiction. The traditions of magical realism in the twentieth-century fiction revealed the following features: an ironic type of artistic integrity; dual worlds and miracles; fantasy intertwined with reality; myths, traditions, and legends; archetypes (father, savior, eternal lover, etc.) and symbols (tree, sea, etc.); unmotivated fantasy; fantastical timeline with no clear boundaries between the past and the future; a highly rhythmical pattern, etc.
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Zhang, Shunan, ShaoPeng Che, Dongyan Nan, and Jang Hyun Kim. "MOOCs as a Research Agenda: Changes Over Time." International Review of Research in Open and Distributed Learning 23, no. 4 (November 1, 2022): 193–210. http://dx.doi.org/10.19173/irrodl.v23i4.6361.
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MOOCs (massive open online courses) have attracted considerable attention from researchers. Fueled by constant change and developments in educational technology, the trends of MOOCs have varied greatly over the years. To detect and visualize the developments and changes in MOOC research, 4,652 articles published between 2009 and 2021 were retrieved from Web of Science and Scopus with the aid of CiteSpace. This study sought to explore the number of publications, co-citation network, cluster analysis, timeline analysis, burstness analysis, and dual-map overlays based on co-citation relationships. The first finding was that the number of publications on MOOCs had increased consistently, and grew especially quickly between 2013 and 2015. Second, the main topic of the top 10 co-cited studies revolved around the problem of learner continuance. Third, blended programs, task-technology fit, and comparative analysis have emerged as popular subjects. Fourth, the development of MOOC research has followed distinct phases, with 2009 to 2012 the starting phase, 2013 to 2015 the high growth phase, 2016 to 2018 the plateau phase, and 2019 to 2021 another peak phase. Lastly, both cluster analysis and dual-map overlays provided empirical evidence of cross-disciplinary research. Our findings provided an in-depth and dynamic understanding of the development and evolution of MOOC research and also proposed novel ideas for future studies.
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Joshi, Deval D., Anju Dang, Prem Yadav, Jing Qian, Persis S. Bandari, Kunhua Chen, Robert Donnelly, et al. "Negative feedback on the effects of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study." Blood 98, no. 9 (November 1, 2001): 2697–706. http://dx.doi.org/10.1182/blood.v98.9.2697.
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Abstract Hematopoietic regulation is a complex but dynamic process regulated by intercellular and intracellular interactions within the bone marrow (BM) microenvironment. Through neurokinin-1 (NK-1) and NK-2 receptors, peptides (eg, substance P [SP]) encoded by the preprotachykinin-I gene mediate distinct hematopoietic effects. Cytokines, associated with hematopoietic stimulation, and SP regulate the expression of each other in BM mesenchymal and immune cells. Neutral endopeptidase (NEP) uses SP as a substrate to produce SP(1-4), which inhibits the proliferation of matured myeloid progenitor. This study determines whether the degradation of SP to SP(1-4) by endogenous NEP in BM stroma could be a feedback on hematopoietic stimulation by stem cell factor (SCF). SP(1-4) induced the production of transforming growth factor (TGF)–β and tumor necrosis factor–α in BM stroma. TGF–β production accounted for part of the inhibitory effects by SP(1-4) on the proliferation of early (granulocyte-macrophage colony-forming units) and late (long-term culture-initiating cells) hematopoietic progenitors. Enzyme-linked immunosorbent assays and/or protein-chip arrays indicated a timeline change of SP to SP(1-4) in BM stroma stimulated with SCF, which correlated with increase in NEP messenger RNA. Since SP and its fragment, SP(1-4), interact with the same receptor to mediate opposing hematopoietic effects, 2 interactive studies were done to understand the dual responses of NK-1: (1) a 3-dimensional molecular model of NK-1 and SP and (2) screening of a random dodecapeptide library for SP(1-4) interacting sites. The effects of SP(1-4) on hematopoietic progenitors and the timeline change of SP to SP(1-4), together with the 3-dimensional model, provide a partial explanation for the feedback on the stimulatory effects of SCF and SP on hematopoiesis.
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Gray, Julie McLaughlin, Ling Yu (Elena) Meng, Adley Chan, Cameron Chang, Yijun Liu, Liguo Qian, Hui Wang, et al. "Applying Concepts of Curriculum Design and Cultural Adaptation: Collaborating on a Dual-Degree Occupational Therapy Program in Mainland China." Occupational Therapy International 2024 (March 18, 2024): 1–15. http://dx.doi.org/10.1155/2024/1088666.
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Occupational therapy is a profession with origins rooted in Western values. As culture plays an important role in shaping theory and practice, the curriculum design of academic programs that train future rehabilitation professionals should reflect the local context. As part of an international partnership, a dual-degree graduate program in occupational therapy was established between a Chinese and an American university. A team composed of members from both institutions collaborated on culturally adapting an entry-level master’s program in occupational therapy for China, based on a U.S. program, which welcomed its first cohort in September 2019. This article details the timeline and process of program design and adaptation from conception, through implementation to evaluation and revision, with the aim of offering a framework for curriculum adaptation of other academic programs in the U.S. and internationally. The adapted curriculum includes the program mission, vision, and philosophy; the curriculum model with program outcomes and threads; the program scope and sequence; materials and resources; and course-specific objectives, learning activities, and assessments. The authors also share lessons learned through this experience of international collaboration as well as next steps for program evaluation and sustainability. The detailed overview of this international collaboration offers suggestions for individuals and institutions seeking to develop global partnerships and adapt curricula across cultural contexts.
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Li, Xin, Qiushi Li, Liang Wu, Zongcheng Xu, and Jianquan Yao. "Focusing on the Development and Current Status of Metamaterial Absorber by Bibliometric Analysis." Materials 16, no. 6 (March 12, 2023): 2286. http://dx.doi.org/10.3390/ma16062286.
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In this paper, a total of 4770 effective documents about metamaterial absorbers were retrieved from the Web of Science Core Collection database. We scientifically analyzed the co-occurrence network of co-citation analysis by author, country/region, institutional, document, keywords co-occurrence, and the timeline of the clusters in the field of metamaterial absorber. Landy N. I.’s, with his cooperator et al., first experiment demonstrated a perfect metamaterial absorber microwave to absorb all incidents of radiation. From then on, a single-band absorber, dual-band absorber, triple-band absorber, multi-band absorber and broad-band absorber have been proposed and investigated widely. By integrating graphene and vanadium dioxide to the metamaterial absorber, the frequency-agile functionality can be realized. Tunable absorption will be very important in the future, especially metamaterial absorbers based on all-silicon. This paper provides a new research method to study and evaluate the performance of metamaterial absorbers. It can also help new researchers in the field of metamaterial absorbers to achieve the development of research content and to understand the recent progress.
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Sharpe, Nicola. "Volkswagen's Bad Decisions & Harmful Emissions: How Poor Process Corrupted Codetermination in Germany's Dual Board Structure." Michigan Business & Entrepreneurial Law Review, no. 7.1 (2017): 49. http://dx.doi.org/10.36639/mbelr.7.1.volkswagen.
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This Article directly challenges the often argued proposition that Germany's two-tier board of directors is superior to America’s single-tier board structure. It argues that regardless of structure, any decision-making body that lacks effective decision-making processes is at significant risk of failure, scandal, and ineffectiveness. Legal scholars and policymakers have largely ignored the connection between decision-making processes and the efficacy of corporate leadership. The Article is the first to examine this underexplored relationship in the context of the German dual-board. Volkswagen’s 2015 emissions scandal provides a vehicle to critically assess the relationship between Germany’s two-tiered board and an effective decision-making process. This Article argues that the structure of Volkwagen’s dual board did not automatically result in an effective decision-making processes. Additionally, an effective decision-making process—the attributes of which can be found in organizational behavior theory—is essential to helping German boards accomplish their legislative mandate. Moreover, it is essential to helping the boards of transnational corporations, which have a wide range of structural variations, effectively govern the organizations for whom they work. In sum, Volkswagen and other German corporations may follow the structural requirements of German corporate law, but without effective processes, German directors are likely to fail in their monitoring and supervisory roles. Without effective processes, directors are watchers asleep at their post, uninformed, dormant, and ineffective in preventing gross failures of corporate integrity. Unless German boards adopt and implement a Process-Oriented Approach, the Volkswagen emission scandal will simply be another mark on a timeline for a century plagued by corporate failure.
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Wingerson, Mathew J., Corrine N. Seehusen, Julie C. Wilson, Katherine L. Smulligan, Robert C. Lynall, Vipul Lugade, and David R. Howell. "Smartphone Measured Single- and Dual-Task Gait Evaluation in Adolescents Post-Concussion: A Longitudinal Comparison to Healthy Controls." Orthopaedic Journal of Sports Medicine 10, no. 5_suppl2 (May 1, 2022): 2325967121S0045. http://dx.doi.org/10.1177/2325967121s00454.
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Background: Impairments in postural stability are common following concussion. However, subjectively-scored assessments of postural control, such as the Balance Error Scoring System, may not accurately reflect postural instability. Objective measures, such as gait performance, can more accurately identify ongoing impairments in postural control throughout concussion recovery. Recent technological advances make gait evaluations more feasible across different clinical settings. Purpose: To compare performance on smartphone measured single- and dual-task gait evaluations among adolescent concussion participants and healthy controls across two timepoints. Methods: We evaluated concussed participants at initial (n=13; 14.6±1.3 years; 54% female; 5.5±1.6 days post-concussion) and follow-up visits (33.2±3.3 days post-concussion), and healthy control participants (n=21; 15.5±1.6 years; 48% female) at two timepoints 27.3±0.7 days apart on single- and dual-task gait performance. Single-task gait trials consisted of walking at a self-selected pace for 20 meters. Single-task cognitive trials involved responding to a cognitive task while standing in place. For dual-task trials, participants completed gait and cognitive tasks simultaneously. During each trial a smartphone affixed to the lumbar spine measured gait velocity and cognitive response accuracy and response time. We conducted a 2x2 mixed effects ANOVA to examine changes between groups across the testing timeline. Results: Concussion participants reported significantly greater symptom severity than control participants at the initial timepoint (23.1±13.5 vs 7.4±8.5; p=0.001); however, this difference did not persist to the second timepoint (p=0.99). The concussion group demonstrated significant improvements in single-task gait velocity between timepoints; although, between-group differences in gait velocity were not observed at either timepoint (Figure 1). No differences in cognitive accuracy between groups were identified. However, concussed participants performed worse than healthy controls on cognitive response time at both time points in single- and dual-task testing (Figure 2). Further, response time improved between testing periods for single-task, but not dual-task, conditions. Conclusion: Smartphone gait evaluations indicate improvement in single-task gait velocity during concussion recovery. However, no significant differences in gait velocity were found between concussed and control participants at either time point in single- or dual-task gait conditions. Interestingly, concussion patients had slower cognitive responses than healthy controls at both time points, despite no differences in cognitive accuracy or symptom severity at time 2. Our preliminary findings suggest that smartphone gait evaluations are effective in measuring changes in gait velocity and cognitive performance following adolescent concussion, as well as detecting subtle differences in gait and cognitive performance between concussed and control patients throughout recovery. [Figure: see text][Figure: see text]
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Ojha, Varun, Mukul Bhatt, Rupam Singh, Pallavi, and Bhupesh Goyal. "Exploring dual diagnosis: Examining professional’s knowledge, attitudes, and training on intellectual disability and psychiatric disorder." Multidisciplinary Reviews 6 (March 30, 2024): 2023ss050. http://dx.doi.org/10.31893/multirev.2023ss050.
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People with Intellectual Disabilities (ID) and a Psychiatric Disorder (PD) are referred to as having a dual diagnosis (DD). Mental health (MH) professionals must possess the necessary skills and a positive outlook to care for people with DD adequately. Through appropriate instruction, these goals are achievable. ID and mental problems co-occurring are referred to as a DD, presenting complicated issues for those with ID and those with mental illnesses that work with them. To better understand the gaps and prospects for advancement in this area, this research set out to investigate the attitudes, knowledge, and training on ID and PD of professionals in relation to DD. This study on professional caregivers' attitudes, knowledge, and training about people with DD, ID, and PD supports extensive training programs to fill in knowledge gaps, encourage positive attitudes, and improve abilities while working with this group. For experts to give patients with DD the best service feasible, their attitudes, knowledge, and training must all be enhanced. The purpose of developing this approach was to discover manuscripts that have been published in English after the year 1995. By locating relevant literature within the required timeline and language, this method attempted to make sure that the articles chosen fit the parameters and goals of the study or research that was carried out. This study selected and examined six papers on knowledge, attitudes, and training on ID and PD in the area of DD. The outcome of this study underlines the need to provide practitioners in the DD sector with chances for training and practice to increase their knowledge, competence, and attitudes. Recommendations are offered in light of this evaluation for enhancing guidance opportunities and carrying out additional studies.
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Cramb, Justin, and Victor D. Thompson. "Dynamic Sustainability, Resource Management, and Collective Action on Two Atolls in the Remote Pacific." Sustainability 14, no. 9 (April 25, 2022): 5174. http://dx.doi.org/10.3390/su14095174.
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Examples of environmental transformation, the creation of sustainable lifeways, and the development of environmentally aware political forms better our understanding of how peoples build on tradition and environmental circumstance to form novel institutions. Using archaeological data, oral histories, genealogies, radiocarbon dating, and Bayesian modeling, we present a timeline of habitation and land-use patterns on Manihiki and Rakahanga, two remote atolls in East Polynesia. We track socioecological change on the atolls from the time of first colonization ca. AD 1200–1400 through to sustained European contact in the mid-1800s. The findings document and temporally anchor collective action-based processes of landscape transformation, the development of a system of cyclical mass migration aimed at sustainable resource use, and the implementation of a novel dual-chiefdom political system. This demonstrates that new levels of political “complexity” manifest as patterns of shifting hierarchy and novel forms of political and ecological management, and can arise in relation to specific social and ecological challenges in systems of any size. The perpetuation and adaptation of aspects of these traditional institutions can help to maintain the sustainability of populations today in the face of climatic and social change.
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Cramb, Justin, and Victor D. Thompson. "Dynamic Sustainability, Resource Management, and Collective Action on Two Atolls in the Remote Pacific." Sustainability 14, no. 9 (April 25, 2022): 5174. http://dx.doi.org/10.3390/su14095174.
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Examples of environmental transformation, the creation of sustainable lifeways, and the development of environmentally aware political forms better our understanding of how peoples build on tradition and environmental circumstance to form novel institutions. Using archaeological data, oral histories, genealogies, radiocarbon dating, and Bayesian modeling, we present a timeline of habitation and land-use patterns on Manihiki and Rakahanga, two remote atolls in East Polynesia. We track socioecological change on the atolls from the time of first colonization ca. AD 1200–1400 through to sustained European contact in the mid-1800s. The findings document and temporally anchor collective action-based processes of landscape transformation, the development of a system of cyclical mass migration aimed at sustainable resource use, and the implementation of a novel dual-chiefdom political system. This demonstrates that new levels of political “complexity” manifest as patterns of shifting hierarchy and novel forms of political and ecological management, and can arise in relation to specific social and ecological challenges in systems of any size. The perpetuation and adaptation of aspects of these traditional institutions can help to maintain the sustainability of populations today in the face of climatic and social change.
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Shang, Zhiming, and Liming Zhang. "The Sustainable Digitalization in the Manufacturing Industry: A Bibliometric Analysis and Research Trend." Mobile Information Systems 2022 (January 18, 2022): 1–11. http://dx.doi.org/10.1155/2022/1451705.
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Digital technologies are shown to perform a vital role in developing a resource-efficient industrial base. The effective adoption of digital technologies can help reduce costs and improve the sustainability and flexibility of manufacturing industries. However, how digital technologies favor the transition towards manufacturing systems has not been analyzed in detail yet, so more conceptual and empirical investigation is required in this field. This study investigates the digital transformation trend in the manufacturing industry by combining the bibliometric method with life cycle mode and literature mining. An integrated data analysis system (IDAS) is developed, which includes data collection, data analysis, and visualization processes. As a result, dual-map overlay, keywords clusters, Timeline, and Time zone views are visualized to identify the research trend with the three main aspects: design, larger integrated circuit, and sustainable manufacturing concept evolution. Besides, to recognize potentials for future development of the domain, life cycle model-based technological trajectory is identified, constructing an information society, the combination of tools, and the performance improvement of the whole digital transformation. Moreover, in response to sustainable development, a system considering business strategies and cultural delivery, technological integration, and partner participation and evaluation is developed, which could cope with complex manufacturing processes due to different industrial tasks in different regions.
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Laiadi, Oualid, Ikram Remadna, El yamine Dris, Redouane Drai, Sadek Labib Terrissa, and Noureddine Zerhouni. "Contrastive Metric Learning Loss-Enhanced Multi-Layer Perceptron for Sequentially Appearing Clusters in Acoustic Emission Data Streams." PHM Society European Conference 8, no. 1 (June 27, 2024): 10. http://dx.doi.org/10.36001/phme.2024.v8i1.4134.
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Conventional structural health monitoring methods for interpreting unlabeled acoustic emission (AE) data typically rely on generic clustering approaches. This work introduces a novel approach for analyzing sequential and temporal acoustic emission (AE) data streams by enhancing a Multi-Layer Perceptron (MLP) with a contrastive metric learning loss function (MLP-CMLL)and Time Series K-means (TSKmeans) clustering. This dual approach, MLP-CMLL with TSKmeans, is crafted to refine cluster differentiation significantly. This method is designed to optimize cluster differentiation, bringing similar acoustic patterns closer and distancing divergent ones, thereby improving the MLP's ability to classify acoustic events over time. Addressing the limitations of traditional clustering algorithms in handling the temporal dynamics of AE data, MLP-CMLL with TSKmeans approach provides deeper insights into cluster formation and evolution. It promises enhanced monitoring and predictive maintenance capabilities in engineering applications by capturing the complex dynamics of AE data more effectively, offering a significant advancement in the field of structural health monitoring. Through experimental validation, we apply this method to characterize the loosening phenomenon in bolted structures under vibrations. Comparative analysis with two standard clustering methods using raw streaming data from three experimental campaigns demonstrates that our proposed method not only delivers valuable qualitative information concerning the timeline of clusters but also showcases superior performance in terms of cluster characterization.
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Martino, Massimo, Filippo Antonio Canale, Caterina Alati, Iolanda Donatella Vincelli, Tiziana Moscato, Gaetana Porto, Barbara Loteta, et al. "CART-Cell Therapy: Recent Advances and New Evidence in Multiple Myeloma." Cancers 13, no. 11 (May 27, 2021): 2639. http://dx.doi.org/10.3390/cancers13112639.
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Despite the improvement in survival outcomes, multiple myeloma (MM) remains an incurable disease. Chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA) represents a new strategy for the treatment of relapsed/refractory MM (R/R). In this paper, we describe several recent advances in the field of anti-BCMA CAR T-cell therapy and MM. Currently, available data on anti-BCMA CART-cell therapy has demonstrated efficacy and manageable toxicity in heavily pretreated R/R MM patients. Despite this, the main issues remain to be addressed. First of all, a significant proportion of patients eventually relapse. The potential strategy to prevent relapse includes sequential or combined infusion with CAR T-cells against targets other than BCMA, CAR T-cells with novel dual-targeting vector design, and BCMA expression upregulation. Another dark side of CART therapy is safety. Cytokine release syndrome (CRS) andneurologic toxicity are well-described adverse effects. In the MM trials, most CRS events tended to be grade 1 or 2, with fewer patients experiencing grade 3 or higher. Another critical point is the extended timeline of the manufacturing process. Allo-CARs offers the potential for scalable manufacturing for on-demand treatment with shorter waiting days. Another issue is undoubtedly going to be access to this therapy. Currently, only a few academic centers can perform these procedures. Recognizing these issues, the excellent response with BCMA-targeted CAR T-cell therapy makes it a treatment strategy of great promise.
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Fisher, Marisa M., Cristina N. Perez Chumbiauca, Kieren J. Mather, Raghavendra G. Mirmira, and Sarah A. Tersey. "Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA." Endocrinology 154, no. 9 (July 3, 2013): 3476–81. http://dx.doi.org/10.1210/en.2013-1223.
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Noninvasive detection of early β-cell death in type 1 diabetes might identify individuals in whom therapeutic interventions would preserve β-cell mass and prevent hyperglycemia. Recent studies in mice have shown that β-cell death produces a corresponding increase in unmethylated preproinsulin (PPI) DNA in serum. Here, we report the development of a novel assay using dual fluorescent-probe multiplex PCR (TaqMan) to detect differential methylation of circulating PPI DNA. Key assay features include low background signals, linear assay output across a large range of values, and simultaneous detection of methylated and unmethylated PPI DNA in a single reaction. We defined the “unmethylation index” as a summary parameter that reflects the relative amounts of unmethylated vs methylated PPI DNA. To validate this assay's ability to detect β-cell death in vivo, we measured the unmethylation index in the serum of diabetic mouse models, including high- and multiple low-dose streptozotocin-induced diabetes, and the nonobese diabetic mouse model of type 1 diabetes. Our data show a significantly increased unmethylation index concordant with the known timeline of β-cell death that precedes the onset of hyperglycemia. Subsequently, we observed a decrease in the unmethylation index following diabetes development, likely reflecting the absence of further β-cell death in the pancreas. We conclude that simultaneous measurement of methylated and unmethylated PPI DNA using the multiplex PCR method described here is a readily available and sensitive indicator of dying β-cells that may be useful to track diabetes progression and response to therapeutic intervention.
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Mazzarella, Joseph M. "AGN and Starbursts in Dusty Galaxy Mergers: Insights from the Great Observatories All-sky LIRG Survey." Proceedings of the International Astronomical Union 9, S304 (October 2013): 356–62. http://dx.doi.org/10.1017/s1743921314004311.
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AbstractThe Great Observatories All-sky LIRG Survey (GOALS) is combining imaging and spectroscopic data from the Herschel, Spitzer, Hubble, GALEX, Chandra, and XMM-Newton space telescopes augmented with extensive ground-based observations in a multiwavelength study of approximately 180 Luminous Infrared Galaxies (LIRGs) and 20 Ultraluminous Infrared Galaxies (ULIRGs) that comprise a statistically complete subset of the 60μm-selected IRAS Revised Bright Galaxy Sample. The objects span the full range of galaxy environments (giant isolated spirals, wide and close pairs, minor and major mergers, merger remnants) and nuclear activity types (Seyfert 1, Seyfert 2, LINER, starburst/HII), with proportions that depend strongly on the total infrared luminosity. I will review the science motivations and present highlights of recent results selected from over 25 peer-reviewed journal articles published recently by the GOALS Team. Statistical investigations include detection of high-ionization Fe K emission indicative of deeply embedded AGN, comparison of UV and far-IR properties, investigations of the fraction of extended emission as a function of wavelength derived from mid-IR spectroscopy, mid-IR spectral diagnostics and spectral energy distributions revealing the relative contributions of AGN and starbursts to powering the bolometric luminosity, and quantitative structure analyses that delineate the evolution of stellar bars and nuclear stellar cusps during the merger process. Multiwavelength dissections of individual systems have unveiled large populations of young star clusters and heavily obscured AGN in early-stage (II Zw 96), intermediate-stage (Mrk 266, Mrk 273), and late-stage (NGC 2623, IC 883) mergers. A recently published study that matches numerical simulations to the observed morphology and gas kinematics in mergers has placed four systems on a timeline spanning 175-260 million years after their first passages, and modeling of additional (U)LIRGs is underway. A very brief description of ongoing work with Herschel and ALMA will be given. The talk will conclude with a discussion of the demographics of dual AGN (kpc-scale orbits) in the GOALS sample, including the difficulty of their detection and confirmation, a proposed sequence representing a progression from dual AGN to binary AGNs (sub-pc scale orbits), and implications for the scarcity of confirmed binary QSOs in recent large surveys. Grant support from NASA is gratefully acknowledged.
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Bhowmick, Samrat, and Soumyabrata Chatterjee. "Towards timelike singularity via AdS dual." International Journal of Modern Physics A 32, no. 21 (July 30, 2017): 1750122. http://dx.doi.org/10.1142/s0217751x17501226.
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It is well known that Kasner geometry with spacelike singularity can be extended to bulk AdS-like geometry, furthermore, one can study field theory on this Kasner space via its gravity dual. In this paper, we show that there exists a Kasner-like geometry with timelike singularity for which one can construct a dual gravity description. We then study various extremal surfaces including spacelike geodesics in the dual gravity description. Finally, we compute correlators of highly massive operators in the boundary field theory with a geodesic approximation.
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Şahiner, Burak, Mustafa Kazaz, and Hasan Hüseyin Uğurlu. "Examining Motion of a Robot End-effector Using CurvatureTheory of Dual LorentzianUnitSphericalTimelikeCurves." Afyon Kocatepe University Journal of Sciences and Engineering 18, no. 2 (August 2, 2018): 468–76. http://dx.doi.org/10.5578/fmbd.67272.
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Wei, Keyu. "The Impact of RCEP Tariff Concessions on Intra-Regional Trade: An Analysis of Trade Creation and Diversion." Highlights in Business, Economics and Management 31 (May 21, 2024): 145–55. http://dx.doi.org/10.54097/9fpgy060.
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This study delves into the economic ramifications of the Regional Comprehensive Economic Partnership (RCEP), particularly focusing on its tariff concessions and their influence on intra-regional trade dynamics within the Asia-Pacific region. By encompassing 15 East Asian and Pacific nations, RCEP stands as the world's largest trading bloc, accounting for approximately 30% of the global Gross Domestic Product (GDP). This research aims to dissect the core objectives of RCEP, emphasizing the significant tariff concessions that aim to eliminate up to 90% of the tariffs within the bloc over a stipulated timeline. Through a comprehensive analysis, this paper explores the dual phenomena of trade creation and trade diversion as intrinsic outcomes of RCEP's tariff concessions. Initial findings project an increase in intraregional exports by nearly 2%, translating to an augmentation of approximately US$42 billion. This surge in trade volume is attributed to the lowered costs of goods due to reduced tariffs, fostering economic growth and integration of regional markets. However, the study also highlights the nuanced impacts of trade diversion, where trade shifts from more efficient external sources to less efficient member states, induced by preferential treatment within the bloc. Furthermore, the paper navigates through the challenges and opportunities presented by RCEP, including the harmonization of trade policies and regulatory standards across diverse economic landscapes. The research underscores the strategic implications for RCEP member countries, advocating for a multifaceted approach to leverage the benefits of the agreement while mitigating potential downsides. This study contributes to the broader discourse on regional economic cooperation and integration, offering insights into the complex interplay between trade policies and regional dynamics in the Asia-Pacific.
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Körpınar, Talat, Essin Turhan, and Selcuk Bas. "Characterizing of dual focal curves in D₁³." Boletim da Sociedade Paranaense de Matemática 31, no. 2 (December 12, 2013): 77. http://dx.doi.org/10.5269/bspm.v31i2.16054.
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Mofarreh, Fatemah, and Rashad A. Abdel-Baky. "One-Parameter Hyperbolic Dual Spherical Movements and Timelike Ruled Surfaces." Symmetry 15, no. 4 (April 13, 2023): 902. http://dx.doi.org/10.3390/sym15040902.
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In this paper, explicit expressions were improved for timelike ruled surfaces with the similarity of hyperbolic dual spherical movements. From this, the well known Hamilton and Mannhiem formulae of surfaces theory are attained at the hyperbolic line space. Then, by employing the E. Study map, a new timelike Plücker conoid is immediately founded and its geometrical properties are examined. In addition, via the height dual function, we specified the connection among the timelike ruled surface and the order of contact with its timelike Disteli-axis. Lastly, a classification for a timelike line to be a stationary timelike Disteli-axis is attained and explained in detail. Our findings contribute to a deeper realization of the cooperation between hyperbolic spatial movements and timelike ruled surfaces, with potential implementations in fields such as robotics and mechanical engineering.
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Alluhaibi, Nadia, and Rashad A. Abdel-Baky. "Kinematic Geometry of Timelike Ruled Surfaces in Minkowski 3-Space E13." Symmetry 14, no. 4 (April 5, 2022): 749. http://dx.doi.org/10.3390/sym14040749.
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Symmetry is a frequently recurring theme in mathematics, nature, science, etc. In mathematics, its most familiar manifestation appears in geometry, most notably line geometry, and in other closely related areas. In this study, we take advantage of the symmetry properties of both dual space and original space in order to transfer problems in original space to dual space. We use E. Study Mappingas a direct method for analyzing the kinematic geometry of timelike ruled and developable surfaces. Then, the invariants for a spacelike line trajectory are studied and the well-known formulae of Hamilton and Mannheim on the theory of surfaces are provenfor the line space. Meanwhile, a timelike Plücker conoid generated by the Disteli-axis is derived and its kinematic geometry is discussed. Finally, some equations for particular timelike ruled surfaces, such as the general timelike helicoid, the Lorentzian sphere, and the timelike cone, are derived and plotted.
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Abdel-Baky, Rashad A., and Fatemah Mofarreh. "A Study on the Bertrand Offsets of Timelike Ruled Surfaces in Minkowski 3-Space." Symmetry 14, no. 4 (April 9, 2022): 783. http://dx.doi.org/10.3390/sym14040783.
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This work extends some classical results of Bertrand curves to timelike ruled and developable surfaces using the E. Study map. This provides support to define two timelike ruled surfaces which are offset in the sense of Bertrand. It is proved that every timelike ruled surface has a Bertrand offset if and only if an equation should be satisfied among their dual invariants. In addition, some new results and theorems concerning the developability of the Bertrand offsets of timelike ruled surfaces are gained.
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KAHRAMAN, Tanju, and Hasan Hüseyin UĞURLU. "Dual Smarandache Curves of a Timelike Curve lying on Unit dual Lorentzian Sphere." Mathematical Sciences and Applications E-Notes 4, no. 2 (October 30, 2016): 1–13. http://dx.doi.org/10.36753/mathenot.421439.
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Alluhaibi, Nadia, Rashad A. Abdel-Baky, and Monia Naghi. "On the Bertrand Offsets of Timelike Ruled Surfaces in Minkowski 3-Space." Symmetry 14, no. 4 (March 24, 2022): 673. http://dx.doi.org/10.3390/sym14040673.
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This work examines some classical results of Bertrand curves for timelike ruled and developable surfaces using the E. Study map. This provides the ability to define two timelike ruled surfaces which are offset in the sense of Bertrand. It is shown that every timelike ruled surface has a Bertrand offset if and only if an equation should be satisfied between the dual geodesic curvatures. Some new results and theorems related to the developability of the Bertrand offsets of timelike ruled surfaces are also obtained.
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Önder, Mehmet, and H. Hüseyin Uğurlu. "On the invariants of Mannheim offsets of timelike ruled surfaces with spacelike rulings." Asian-European Journal of Mathematics 08, no. 01 (March 2015): 1550009. http://dx.doi.org/10.1142/s1793557115500096.
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In this paper, we give the characterizations for Mannheim offsets of timelike ruled surfaces with spacelike rulings in dual Lorentzian space [Formula: see text]. We obtain the relations between terms of their integral invariants and also we give new characterization for the Mannheim offsets of developable timelike ruled surface. Moreover, we find relations between the area of projections of spherical images for Mannheim offsets of timelike ruled surfaces and their integral invariants.
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Almoneef, Areej A., and Rashad A. Abdel-Baky. "Timelike Constant Axis Ruled Surface Family in Minkowski 3-Space." Symmetry 16, no. 6 (May 31, 2024): 677. http://dx.doi.org/10.3390/sym16060677.
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A timelike (TL) constant axis ruled surface in E13 (Minkowski 3-space), as determined by its ruling, forms a constant dual angle with its Disteli-axis (striction axis or curvature axis). In this article, we employ the symmetry through point geometry of Lorentzian dual curves and the line geometry of TL ruled surfaces. This produces the capability to expound a set of curvature functions that specify the local configurations of TL ruled surfaces. Then, we gain some new constant axis ruled surfaces in Lorentzian line space and their geometrical illustrations. Further, we also earn several organizations among a TL constant axis ruled surface and its striction curve.
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Fletcher, Andrew, Roger Lawes, and Cameron Weeks. "Crop area increases drive earlier and dry sowing in Western Australia: implications for farming systems." Crop and Pasture Science 67, no. 12 (2016): 1268. http://dx.doi.org/10.1071/cp16200.
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Technologies such as minimum tillage and new herbicides have enabled the use of early and dry sowing in Western Australia (WA). Although there is a sowing date that maximises yield of individual fields, on-farm sowing dates are constrained by the availability of machinery and labour. It was hypothesised that farms with a larger crop area would begin sowing earlier and be more likely to dry sow than smaller farms because they would take longer to sow. Current sowing dates and the extent of dry sowing in WA were explored using multiple analytical approaches, such as analysis of farm records, survey data and historical weather records, and simulation modelling. Field records from seven farms showed that sowing date of the first cereal crop on-farm had advanced markedly in recent years. The timeline of this advanced cereal sowing date differed across sites but was prominent from 2010 for most sites. In a larger survey, conducted between 2011 and 2014, of 805 grain farms across all rainfall zones in the WA grain belt, the mean first crop sowing date was 29 April and half the farms used dry sowing. Farms with larger cropped areas tended to begin sowing crops earlier and were more likely to dry sow. Only 26% of small farms (<1000 ha crop) used dry sowing compared with 71% of large farms (>5000 ha crop). A larger proportion of lupin (34%) and canola (43%) was sown dry than wheat (16%) or barley (10%; P < 0.001). Simulation modelling demonstrated that the optimum time to begin sowing at the farm level was often well before the break of season (the first autumn rainfall of sufficient volume to ensure subsequent successful crop germination and establishment), but this was dependant on the size of the cropping program. Early and dry sowing will continue to expand, and research to understand how other agronomic management interacts with this change should be a priority. This may include cultivars with appropriate traits, such as longer duration to flowering, changes in weed management practices, management practices that accumulate soil moisture at sowing, interactions with water repellent soil and the interaction with dual purpose cropping.
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Önder, Mehmet, and Zehra Ekinci. "On the kinematic interpretation of timelike ruled surfaces." International Journal of Geometric Methods in Modern Physics 12, no. 10 (October 25, 2015): 1550127. http://dx.doi.org/10.1142/s0219887815501273.
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Timelike ruled surfaces are studied in dual Lorentzian space [Formula: see text] by considering E. Study Mapping and Blaschke frame. A reference timelike ruled surface is considered and associated surfaces are defined. First, it is shown that the surface generated by the instantaneous screw axis (ISA) is a Mannheim offset of reference surface. Later, the kinematic interpretations between these surfaces are introduced by means of Blaschke invariants.
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Önder, Mehmet, and H. Hüseyin Uğurlu. "Dual Darboux Frame of a Timelike Ruled Surface and Darboux Approach to Mannheim Offsets of Timelike Ruled Surfaces." Proceedings of the National Academy of Sciences, India Section A: Physical Sciences 83, no. 2 (April 11, 2013): 163–69. http://dx.doi.org/10.1007/s40010-013-0067-7.
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Almoneef, Areej A., and Rashad A. Abdel-Baky. "Kinematic Geometry of a Timelike Line Trajectory in Hyperbolic Locomotions." Axioms 12, no. 10 (September 26, 2023): 915. http://dx.doi.org/10.3390/axioms12100915.
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This study utilizes the axodes invariants to derive novel hyperbolic proofs of the Euler–Savary and Disteli formulae. The inflection circle, which is widely recognized, is situated on the hyperbolic dual unit sphere, in accordance with the principles of the kinematic theory of spherical locomotions. Subsequently, a timelike line congruence is defined and its spatial equivalence is thoroughly studied. The formulated assertions degenerate into a quadratic form, which facilitates a comprehensive understanding of the geometric features of the inflection line congruence.
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Lawrence, Yaacov Richard, Sivan Lieberman, Ilanit Redinsky, Nir Honig, Einat Shacham-Shmueli, Naama Halpern, Stephen Raskin, et al. "Combination treatment of intratumoral vidutolimod (CMP-001), radiosurgery, nivolumab, and ipilimumab for metastatic colorectal carcinoma." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 123. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.123.
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123 Background: Microsatellite stable (MSS) or mismatch repair proficient (MMR-P) metastatic colorectal cancer is refractory to immune checkpoint inhibition. We hypothesized that a combination of intratumoral TLR9 agonist, radiosurgery and dual PD-1 and CTLA-4 blockade would induce a local focus of immune stimulation, evoking a systemic immune response. Methods: In this single institution investigator-initiated phase I study, patients with MSS / MMR-P metastatic colorectal cancer were treated with a priming dose of subcutaneous (s.c.) vidutolimod, three intratumoral injections of vidutolimod, and radiosurgery to a metastasis, combined with nivolumab 3mg/kg every 2 weeks and ipilimumab 1 mg/kg every 6 weeks. Following conclusion of intratumoral therapy, s.c. injections of vidutolimod commenced. Efficacy endpoints were based upon a non-irradiated and non-injected lesion. Cytokine levels were measured at baseline and at 7 (± 2) weeks. Patients were placed in 4 cohorts: (1) Safety run-in without radiosurgery (No RT); (2) Radiosurgery prior to intratumoral therapy (Early Liver RT Slow). An amendment was made due to early patient fall-out due to progressive disease; (3) Radiosurgery prior to intratumoral therapy with a condensed timeline (Early Liver RT Quick). An additional amendment was made due to unacceptable liver toxicity; (4) Radiosurgery to extrahepatic lesion following completion of intratumoral therapy (Late Extrahepatic RT). ClinicalTrials.gov Identifier NCT03507699. Results: A total of 19 patients were accrued (No RT, n=2; Early Liver RT Slow, n=7; Early Liver RT Quick, n=4; Late Extrahepatic RT, n=6). Median age was 59 years (range 40-71), 68% were male, median number of previous systemic treatments was 3 (range 2 – 5). None of the patients responded, aside from one patient in cohort #4 who achieved complete response, and was subsequently found to have a high tumor mutational burden (TMB) 79 mutations / Mb. Grade 3 liver toxicity, including elevated transaminases and hyperbilirubinemia, was reported in 0%, 0%, 75% and 17% in cohorts 1-4, respectively. Reactions following intratumoral injections, typically within 12 hours, included fever (68%), tachycardia (21%), chills (63%) and hypotension (47%). There was an increase in systemic CXCL10 levels at 7 (± 2) weeks compared to baseline, with a median of 407 versus 78 pg/ml, respectively, p<0.01. Conclusions: Intratumoral liver injection of vidutolimod was associated with acute systemic symptoms attributed to cytokine release. The juxtaposition of liver irradiation and intratumoral vidutolimod injection to the same lesion was associated with unacceptable hepatic toxicity. The combination of intratumoral vidutolimod, radiosurgery, nivolumab and ipilimumab was not found to be efficacious in MSS / MMR-P colon cancer. Clinical trial information: NCT03507699 .
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Sahiner, Burak, Mustafa Kazaz, and Hasan Ugurlu. "A study on motion of a robot end-effector using the curvature theory of dual unit hyperbolic spherical curves." Filomat 30, no. 3 (2016): 791–802. http://dx.doi.org/10.2298/fil1603791s.
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In this paper we study the motion of a robot end-effector by using the curvature theory of a dual unit hyperbolic spherical curve which corresponds to a timelike ruled surface with timelike ruling generated by a line fixed in the end-effector. In this way, the linear and angular differential properties of the motion of a robot end-effector such as velocities and accelerations which are important information in robot trajectory planning are determined. Moreover, the motion of a robot end-effector which moves on the surface of a right circular hyperboloid of one sheet is examined as a practical example.
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ERALP, Yeşim, İzzet DOĞAN, Sercan Aksoy, Burcu ÇAKAR, Gül BAŞARAN, Özlem ERCELEP, Nil MOLİNAS MANDEL, et al. "Abstract P3-02-06: Demographic and clinical features of patients with metastatic HER2 positive breast cancer: a retrospective multicenter registry study of the Turkish Oncology Group." Cancer Research 83, no. 5_Supplement (March 1, 2023): P3–02–06—P3–02–06. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-02-06.
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Abstract Background: Although HER2 is an aggressive subtype of BC, the outcomes have improved over the past two decades due to advances in targeted therapies. Here, we present data of HER2-positive subset from the multicenter registry study of the Turkish Oncology Group (TOG) for metastatic breast cancer with an evolving treatment landscape for over a decade (MBC). Methods: The study of TOG for MBC was a retrospective registry study aimed to collect the data of adult metastatic BC patients diagnosed between 2010-2019, at seven tertiary oncology clinics in Turkey. Patient and disease characteristics were recorded from chart reviews. HER2 (+) was defined as IHC scores of IHC3+ or IHC2+ and ISH (+). Overall survival (OS) and progression-free survival (PFS) were calculated by the Kaplan-Meier method. Correlations between demographic, prognostic variables and survival outcomes were carried out in database aggregates comprising of cohorts based on disease presentation (recurrent vs de-novo) and the diagnosis date of MBC (Cohort I: patient diagnosed between January 2010-December 2014 and Cohort II: between January 2015-December 2019). Results: Of the 1381 patients analyzed over the whole period, 333 (24.1%) HER2 (+) MBC patients were identified. 55.0% of the patients were in Cohort I. The majority (56.8%) had de novo MBC. Despite a decreasing frequency over time (63.4% in Cohort I vs 48.7% in Cohort II, p=0.007), this was the largest group with among all pathological subgroups presenting with de novo disease. 17 patients (2.4% of recurrent patients) demonstrated changes in HER2 receptor status from negative to positive between the primary tumor and subsequent metastasis. Recurrent BC patients were significantly younger than de novo MBC patients [44 (22-80) years vs 49 (20-91) years, p=0.006] and 43.1% (n=62) had relapsed within two years from initial diagnosis. Recurrent BC patients showed a higher frequency of brain metastasis as compared to de novo patients (13.2% vs 1.1%), whereas non-CNS visceral organ metastases were more common in de novo MBC patients (58.7% vs 47.9%, respectively, p< 0.001). Following conditional approval of use in de novo visceral metastatic disease in 2016, dual-HER2 blockade including pertuzumab was more frequently used in Cohort II compared to Cohort I (p< 0.001). Although overall median PFS was not statistically significant between the two cohorts (Cohort II vs I; 22 vs 17 months, respectively, p=0.609), there was a significantly higher PFS in the de novo group in Cohort II (29 vs 17 months, p=0.037). Furthermore, there was a significant improvement in median OS in Cohort II compared to Cohort I [not reached vs 48.0 (40.0-71.0) months, respectively; p=0.017]; mainly driven by the de novo group in alignment with the approval indication for dual blockade (Cohort I vs II; 3-year OS; 62.0% vs 84.7%; p=0.009); especially those with visceral metastatic presentation (59.4% vs 83.4%, p=0.020); HR (+) HER2 (+) disease (61.2% vs 89.2%; p=0.013) and age< 40 years (40.0% vs 94.7%; p=0.009). Conclusion: There was a significant survival benefit achieved in patients with metastatic HER2 (+) disease over time, regardless of high-risk factors such as visceral involvement or young age, mirroring advances in the timeline of anti-HER2 treatment. Citation Format: Yeşim ERALP, İzzet DOĞAN, Sercan Aksoy, Burcu ÇAKAR, Gül BAŞARAN, Özlem ERCELEP, Nil MOLİNAS MANDEL, Taner KORKMAZ, Erhan GÖKMEN, Adnan AYDINER, Pınar SAİP. Demographic and clinical features of patients with metastatic HER2 positive breast cancer: a retrospective multicenter registry study of the Turkish Oncology Group [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-02-06.
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Bektaş, Özcan, and Süleyman Şenyurt. "On Some Characterizations of Ruled Surface of a Closed Timelike Curve in Dual Lorentzian Space." Advances in Applied Clifford Algebras 22, no. 4 (April 4, 2012): 939–53. http://dx.doi.org/10.1007/s00006-012-0327-7.
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Wang, Yongqiao, Lin Yang, Yuxin Liu, and Yuan Chang. "Singularities for Focal Sets of Timelike Sabban Curves in de Sitter 3-Space." Symmetry 14, no. 12 (November 22, 2022): 2471. http://dx.doi.org/10.3390/sym14122471.
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In the theory of cosmology, de Sitter space is the symmetrical model of accelerated expansions of the universe. It is derived from the solution of the Einstein field equation, which has a positive cosmological constant. In this paper, we define the evolutes and focal surfaces of timelike Sabban curves in de Sitter space. We find that de Sitter focal surfaces can be regarded as caustics and de Sitter evolutes corresponding to the locus of the polar vectors of osculating de Sitter subspaces. By using singularity theory, we classify the singularities of the de Sitter focal surfaces and de Sitter evolutes and show that there is a close relationship between a new geometric invariant and the types of singularities. Moreover, the Legendrian dual relationships between the hyperbolic tangent indicatrix of timelike Sabban curves and the focal surfaces are given. Finally, we provide an example to illustrate our main results.
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Almoneef, Areej A., and Rashad A. Abdel-Baky. "One-Parameter Hyperbolic Spatial Locomotions and Invariants of the Axode." Mathematics 11, no. 17 (August 31, 2023): 3749. http://dx.doi.org/10.3390/math11173749.
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In this paper, based on the E. Study map, direct appearances were sophisticated for one-parameter hyperbolic dual spherical locomotions and invariants of the axodes. With the suggested technique, the Disteli formulae for the axodes were acquired and the correlations through kinematic geometry of a timelike line trajectory were provided. Then, a ruled analogy of the curvature circle of a curve in planar locomotions was expanded into generic spatial locomotions. Lastly, we present new hyperbolic proofs for the Euler–Savary and Disteli formulae.
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Mo, Linlin, Liangbo Zhang, Xiaohui Sun, and Zhimin Zhou. "Unlock Happy Interactions: Voice Assistants Enable Autonomy and Timeliness." Journal of Theoretical and Applied Electronic Commerce Research 19, no. 2 (April 30, 2024): 1013–33. http://dx.doi.org/10.3390/jtaer19020053.
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This study examines the effects of three interactive voice assistant (VA) features (responsiveness, ubiquitous connectivity, and personalization) on consumer happiness. An online survey was administered to 316 VA consumers, and the data were analyzed using structural equation modeling with SmartPLS 4 software. The results indicate that VA responsiveness, ubiquitous connectivity, and personalization have significant effects on consumer happiness. This study also provides evidence that consumer happiness is influenced by VA features through the mediating roles of autonomy and timeliness. Notably, perceived privacy risk has a dual effect, negatively affecting happiness but positively moderating the relationship between autonomy and happiness, suggesting a complex interplay between benefits and concerns in user interactions with VAs. This study highlights the need for VA businesses to consider both the enhancing and mitigating factors of technology for user experiences. Furthermore, our findings have significant implications for VA businesses and executives, suggesting that improved interactions through these VA features can better serve consumers and enhance their experiences.
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Zhang, Jianyi, Jingchun Feng, Ke Zhang, and Xun Han. "Research on the Value Improvement Model of Private Parties as “Investor–Builder” Dual-Role Entity in Major River Green Public–Private Partnership Projects." Buildings 13, no. 11 (November 17, 2023): 2881. http://dx.doi.org/10.3390/buildings13112881.
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In Public–Private Partnership (PPP) projects, the structure of the Special Purpose Vehicle (SPV) significantly impacts the value enhancement of projects. This study conducted a quantitative analysis of value enhancement in green PPP projects under single- and Dual-Role entity models and examined existing SPV private party compositions. A quantitative model was developed to enhance the value in green PPP projects through a Dual-Role “investor–builder” entity approach, comparing it with the single-role entity model. The findings indicate that in the Dual-Role entity mode, the construction party demonstrates a greater willingness to effort, resulting in shorter construction timelines and improved economic benefits for the project company. The preferred equity range for private parties escalates with the total project investment and the extent of “political support”. Nevertheless, a disproportionately high government stake in the equity is detrimental to the value enhancement in PPPs, and excessive government regulation and control should be avoided. This quantitative model serves as a decision-making criterion for selecting the SPV mode and provides an alternative approach for evaluating PPP project performance.
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Shah, Nirav N., Fenlu Zhu, Carolyn Taylor, Dina Schneider, Winfried Krueger, Andrew Worden, Sharon Yim, et al. "A Phase 1 Study with Point-of-Care Manufacturing of Dual Targeted, Tandem Anti-CD19, Anti-CD20 Chimeric Antigen Receptor Modified T (CAR-T) Cells for Relapsed, Refractory, Non-Hodgkin Lymphoma." Blood 132, Supplement 1 (November 29, 2018): 4193. http://dx.doi.org/10.1182/blood-2018-99-110194.
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Abstract Background: CAR-T cell therapy directed against the CD19 antigen is a breakthrough treatment for patients (pts) with relapsed/refractory (R/R) B-cell NHL. Despite impressive outcomes, not all pts respond and many that respond still relapse. Affordability and accessibility are further considerations that limit current commercial models of CAR-T products. Commercial CAR-T manufacturing is complex, time consuming, and expensive with a supply chain starting at the treating center with apheresis of mononuclear cells, cryopreservation, and shipping to and from a centralized third-party manufacturing site. We addressed these limitations in a Phase 1 clinical trial evaluating a first-in-human bispecific tandem CAR-T cell directed against both CD19 and CD20 (CAR-20.19-T) antigens for pts with R/R B-cell NHL. Through dual targeting we hope to improve response rates and durability of response while limiting antigen escape. We eliminated third party shipping logistics utilizing the CliniMACS Prodigy, a compact tabletop device that allows for automated manufacturing of CAR-T cells within a GMP compliant environment within the hospital. Most materials and reagents used to produce the CAR-T cell product were single-sourced from the device manufacturer. Methods: Phase 1 (NCT03019055), single center, dose escalation + expansion study to demonstrate feasibility and safety of locally manufactured second generation 41BB + CD3z CAR-20.19-T cells via the CliniMACS Prodigy. Feasibility was measured by ability to generate a target CAR-20.19-T cell dose for a minimum of 75% of subjects. Safety was assessed by the presence of dose limiting toxicities (DLTs) through 28 days post-infusion. Dose was escalated in a 3+3 fashion with a starting dose of 2.5 x 10^5 cells/kg, a target DLT rate <33%, and a goal treatment dose of 2.5 x 10^6 cells/kg. Adults with R/R Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL) or Chronic Lymphocytic Leukemia (CLL) were eligible. CAR-T production was set for a 14-day manufacturing process. Day 8 in-process testing was performed to ensure quality and suitability of CAR-T cells for a potential fresh infusion. On Day 10, pts eligible for a fresh CAR-T infusion initiated lymphodepletion (LDP) chemotherapy with fludarabine 30 mg/m2 x 3 days and cyclophosphamide 500 mg/m2 x 1 day, and cells were administered after harvest on Day 14. Pts ineligible for fresh infusion received cryopreserved product and LDP was delayed accordingly. Results: 6 pts have been enrolled and treated with CAR-20.19-T cells: 3 pts at 2.5 x 10^5 cells/kg and 3 pts at 7.5 x 10^5 cells/kg. Median age was 53 years (48-62). Underlying disease was MCL in 3 pts, DLBCL in 2 pts, and CLL in 1 patient. Baseline data and prior treatments are listed in Table 1. CAR-T production was successful in all runs and all pts received their target dose. Three pts received fresh CAR-T cells and 3 pts received CAR-T cells after cryopreservation. To date there are no DLTs to report. No cases of Grade 3/4 cytokine release syndrome (CRS) or neurotoxicity (NTX) were observed. One patient had Grade 2 CRS and Grade 2 NTX requiring intervention. The other had self-limited Grade 1 CRS and Grade 1 NTX. Median time to development of CRS was Day +11 post-infusion. All pts had neutrophil recovery (ANC>0.5 K/µL) by Day 28. Response at Day 28 (Table 2) is as follows: 2/6 pts achieved a complete response (CR), 2/6 achieved a partial response (PR), and 2/6 had progressive disease (PD). One subject with a PR subsequently progressed at Day 90. The 3 pts who did progress all underwent a repeat biopsy, and all retained either CD19 or CD20 positivity. Pts are currently being enrolled at the target dose (2.5 x 10^6 cells/kg) and updated results will be provided at ASH. Conclusions: Dual targeted anti-CD19 and anti-CD20 CAR-T cells were successfully produced for all pts demonstrating the feasibility of a point-of-care manufacturing process via the CliniMACS Prodigy device. With no DLTs or Grade 3-4 CRS or NTX to report, and 2/6 heavily pre-treated pts remaining in CR at 3 and 9 months respectively our approach represents a feasible and promising alternative to existing CAR-T models and costs. Down-regulation of both target antigens was not identified in any patient following CAR-T infusion, and in-process studies suggest that a shorter manufacturing timeline is appropriate for future trials (10 days). Disclosures Shah: Juno Pharmaceuticals: Honoraria; Lentigen Technology: Research Funding; Oncosec: Equity Ownership; Miltenyi: Other: Travel funding, Research Funding; Geron: Equity Ownership; Exelexis: Equity Ownership. Zhu:Lentigen Technology Inc., A Miltenyi Biotec Company: Research Funding. Schneider:Lentigen Technology Inc., A Miltenyi Biotec Company: Employment. Krueger:Lentigen Technology Inc., A Miltenyi Biotec Company: Employment. Worden:Lentigen Technology Inc., A Miltenyi Biotec Company: Employment. Hamadani:Sanofi Genzyme: Research Funding, Speakers Bureau; Merck: Research Funding; Janssen: Consultancy; MedImmune: Consultancy, Research Funding; Cellerant: Consultancy; Celgene Corporation: Consultancy; Takeda: Research Funding; Ostuka: Research Funding; ADC Therapeutics: Research Funding. Johnson:Miltenyi: Research Funding. Dropulic:Lentigen, A Miltenyi Biotec company: Employment. Orentas:Lentigen Technology Inc., A Miltenyi Biotec Company: Other: Prior Employment. Hari:Takeda: Consultancy, Honoraria, Research Funding; Janssen: Honoraria; Kite Pharma: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Research Funding; Spectrum: Consultancy, Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding; Amgen Inc.: Research Funding; Sanofi: Honoraria, Research Funding.
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Rawal, Amit, Alex Waldman, Omar Saeed, and Asif Khan. "Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion." Clinical Practice and Cases in Emergency Medicine 4, no. 2 (March 2, 2020): 167–70. http://dx.doi.org/10.5811/cpcem.2020.1.44908.
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Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique case of a 62-year-old Asian female who presented with a hemorrhagic stroke suspected to be secondary to refractory hypertension from intracranial large vessel atherosclerotic flow limiting stenosis, with rapid subsequent large vessel occlusion and ischemic stroke. Questions arise such as ideal blood pressure parameters for dual management, timeliness of computed tomography angiography imaging in the emergency department for detection of large vessel occlusion during intracranial hemorrhage, and subsequent selection of treatment plan in the dual-lesion patient population.
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Narayan, K. "de Sitter entropy as entanglement." International Journal of Modern Physics D 28, no. 14 (October 2019): 1944019. http://dx.doi.org/10.1142/s021827181944019x.
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We describe connected timelike codim-2 extremal surfaces stretching between the future and the past boundaries in the static patch coordinatization of de Sitter space. These are analogous to rotated versions of certain surfaces in the AdS black hole. The existence of these surfaces via the [Formula: see text] framework suggests the speculation that [Formula: see text] is dual to two copies of ghost-like CFTs in a thermofield-double-type entangled state. In studies of entanglement in ghost systems and “ghost-spin” chains, we show that similar entangled states in two copies of ghost-spin ensembles always have positive norm and positive entanglement.