Journal articles: 'DTD'

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Lu, Yan. "DTD-Based XML Indexing." Journal of Computer Research and Development 42, no. 1 (2005): 30. http://dx.doi.org/10.1360/crad20050104.

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Cover, Robin. "More than one DTD." Markup Languages: Theory and Practice 3, no. 1 (December 1, 2001): 14–16. http://dx.doi.org/10.1162/109966201753537132.

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Slotnik, Arnold M. "Stupid XML DTD tricks." Markup Languages: Theory and Practice 3, no. 4 (September 1, 2001): 394–98. http://dx.doi.org/10.1162/109966202760152158.

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Kim, Myung-Sook, and Yong-Hae Kong. "XML Query-Expansion by Ontology-DTD Match." KIPS Transactions:PartD 12D, no. 5 (October 1, 2005): 773–80. http://dx.doi.org/10.3745/kipstd.2005.12d.5.773.

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Kobayashi, Hirofumi, and Hidehiro Ishizuka. "SGML-DTD design support system." Proceedings of Annual Conference, Japan Society of Information and Knowledge 3 (1995): 95–98. http://dx.doi.org/10.2964/jsikproc.3.0_95.

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Ioannides, Demetrios. "XML schema languages: beyond DTD." Library Hi Tech 18, no. 1 (March 2000): 9–15. http://dx.doi.org/10.1108/07378830010314366.

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Zainol, Zurinahni, and Bing Wang. "XML Documents Normalization Using GN-DTD." International Journal of Information Retrieval Research 1, no. 1 (January 2011): 53–76. http://dx.doi.org/10.4018/ijirr.2011010105.

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Designing a well-structured XML document is important for the sake of readability, maintainability and more importantly to avoid both data redundancies and update anomalies. This paper proposes to improve and simplify XML structural design using a normalization process. To achieve this, Graphical Notation for Document Type Definition (GN-DTD) is used to describe the structure of XML document at the schema level. Multiple levels of normal forms for GN-DTD are proposed and the corresponding normalization rules to transform from poorly designed into well-designed XML documents. A case study is presented to show the application of these normal forms and normalization algorithm.

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Lavignasse, Sophie. "La DTD et son langage XML." Éla. Études de linguistique appliquée 137, no. 1 (2005): 73. http://dx.doi.org/10.3917/ela.137.0073.

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Basci, Dilek, and Sanjay Misra. "Entropy metric for XML DTD documents." ACM SIGSOFT Software Engineering Notes 33, no. 4 (July 2008): 1–6. http://dx.doi.org/10.1145/1384139.1384144.

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Nyberg, Karl. "Automatically generating DTD-specific XML parsers." ACM SIGAda Ada Letters 30, no. 2 (August 30, 2010): 13–18. http://dx.doi.org/10.1145/2593988.2593989.

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Nam, Si-Byung, Ki-Hyeon Kwon, and Myung-Han Yu. "Design and Implementation of USN Middleware using DTD GenerationTechnique." Journal of the Korea Society of Computer and Information 17, no. 3 (March 30, 2012): 41–50. http://dx.doi.org/10.9708/jksci.2012.17.3.041.

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van Der Kolk, Bessel, Julian D. Ford, and Joseph Spinazzola. "Comorbidity of developmental trauma disorder (DTD) and post-traumatic stress disorder: findings from the DTD field trial." European Journal of Psychotraumatology 10, no. 1 (January 29, 2019): 1562841. http://dx.doi.org/10.1080/20008198.2018.1562841.

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Džigurski, Dejana, Ljiljana Nikolić, and Branka Ljevnaić-Mašić. "Elodea canadensis in the vegetation of HS DTD in Bačka." Acta herbologica 25, no. 1 (2016): 71–78. http://dx.doi.org/10.5937/actaherb1601071d.

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Gulati, Harvinder. "Mapping between XML and RDF via DTD." INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 10, no. 6 (August 30, 2013): 1732–37. http://dx.doi.org/10.24297/ijct.v10i6.3200.

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XML has gained massive popularity for representation of data in last decades. Both HTML and XML are used as primary data formats since the existence of World Wide Web. As the amount of data is growing, need has emerged to represent the data in such a manner that it can be recognized by machines rather than only humans. The next generation web, Semantic web aims at representing large amount of data available in www in a machine understandable format. However, XML represent the structure of data and cannot serve the purpose of machine understandability and HTML is too inexpressive to be used by machines for interpretation of data. To bridge this gap between syntax and semantics, current data needs to be converted into Semantic web compatible formats and XML DTDs can directly be converted into RDF. This paper focuses on conversion of data available in XML DTDs into RDF using classes, subclasses and properties.

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Barclay, Sarah F., Ford Burles, Kendra Potocki, Kate M. Rancourt, Mary Lou Nicolson, N. Torben Bech-Hansen, and Giuseppe Iaria. "Familial aggregation in developmental topographical disorientation (DTD)." Cognitive Neuropsychology 33, no. 7-8 (November 16, 2016): 388–97. http://dx.doi.org/10.1080/02643294.2016.1262835.

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Chandler, Rob, and Karen Anderson. "An XML DTD for Subject Related Resources." Australian Academic & Research Libraries 33, no. 3 (January 2002): 189–206. http://dx.doi.org/10.1080/00048623.2002.10755198.

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Zheng, Gen, Wei Liu, Yanhua Gong, Hongbo Yang, Bin Yin, JingXi Zhu, Yi Xie, Xiaozhong Peng, Boqin Qiang, and Jiangang Yuan. "Human D-Tyr-tRNATyr deacylase contributes to the resistance of the cell to D-amino acids." Biochemical Journal 417, no. 1 (December 12, 2008): 85–97. http://dx.doi.org/10.1042/bj20080617.

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DTD (D-Tyr-tRNATyr deacylase) is known to be able to deacylate D-aminoacyl-tRNAs into free D-amino acids and tRNAs and therefore contributes to cellular resistance against D-amino acids in Escherichia coli and yeast. We have found that h-DTD (human DTD) is enriched in the nuclear envelope region of mammalian cells. Treatment of HeLa cells with D-Tyr resulted in nuclear accumulation of tRNATyr. D-Tyr treatment and h-DTD silencing caused tRNATyr downregulation. Furthermore, inhibition of protein synthesis by D-Tyr treatment and h-DTD silencing were also observed. D-Tyr, D-Asp and D-Ser treatment inhibited mammalian cell viability in a dose-dependent manner; overexpression of h-DTD decreased the inhibition rate, while h-DTD-silenced cells became more sensitive to the D-amino acid treatment. Our results suggest that h-DTD may play an important role in cellular resistance against D-amino acids by deacylating D-aminoacyl tRNAs at the nuclear pore. We have also found that m-DTD (mouse DTD) is specifically enriched in central nervous system neurons, its nuclear envelope localization indicates that D-aminoacyl-tRNA editing may be vital for the survival of neurons under high concentration of D-amino acids.

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Seo, Hyo-Hyoun, Ae Ran Park, Hyun-Hwa Lee, Sangkyu Park, Yun-Jeong Han, Quyen T. N. Hoang, Gyung Ja Choi, Jin-Cheol Kim, Young Soon Kim, and Jeong-Il Kim. "A Fungus-Inducible Pepper Carboxylesterase Exhibits Antifungal Activity by Decomposing the Outer Layer of Fungal Cell Walls." Molecular Plant-Microbe Interactions® 31, no. 5 (May 2018): 505–15. http://dx.doi.org/10.1094/mpmi-11-17-0266-r.

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Colletotrichum species are major fungal pathogens that cause devastating anthracnose diseases in many economically important crops. In this study, we observed the hydrolyzing activity of a fungus-inducible pepper carboxylesterase (PepEST) on cell walls of C. gloeosporioides, causing growth retardation of the fungus by blocking appressorium formation. To determine the cellular basis for the growth inhibition, we observed the localization of PepEST on the fungus and found the attachment of the protein on surfaces of conidia and germination tubes. Moreover, we examined the decomposition of cell-wall materials from the fungal surface after reaction with PepEST, which led to the identification of 1,2-dithiane-4,5-diol (DTD) by gas chromatography mass spectrometry analysis. Exogenous DTD treatment did not elicit expression of defense-related genes in the host plant but did trigger the necrosis of C. gloeosporioides. Furthermore, the DTD compound displayed protective effects on pepper fruits and plants against C. gloeosporioides and C. coccodes, respectively. In addition, DTD was also effective in preventing other diseases, such as rice blast, tomato late blight, and wheat leaf rust. Therefore, our results provide evidence that PepEST is involved in hydrolysis of the outmost layer of the fungal cell walls and that DTD has antifungal activity, suggesting an alternative strategy to control agronomically important phytopathogens.

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Jakovljevic, Olga, Jelena Krizmanic, and Mirko Cvijan. "Water quality assessment of the DTD canal system by diatom indices." Zbornik Matice srpske za prirodne nauke, no. 127 (2014): 23–33. http://dx.doi.org/10.2298/zmspn1427023j.

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The main objective of this paper is to evaluate the water quality based on diatom indices in the study area of the Danube-Tisa-Danube (DTD) canal system. We used four diatom indices: Watanabe?s index (DAIpo), biological diatom index (BDI or IBD), the trophic diatom index (TDI) and index of pollution sensitivity (IPS). Benthic samples were collected in the spring and autumn 2002 and 2003 from nine sampling sites. The standard method with concentrated sulfuric acid was used for treatment of the algological samples [Krammer and Lange-Bertalot 1986] and then permanent slides of diatoms were made. The abundance was estimated by counting 400 valves of each taxa present on slide [Round 1991, 1993]. Investigation of the DTD canal system resulted in description of 145 diatom taxa. Based on the indicator values of identified taxa we calculated four diatom indices (DAIpo, BDI, TDI and IPS) and estimated water quality in the study area of the DTD canal system.

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Kim, Chang-Suk, Dong-Cheul Son, and Dae-Su Kim. "A XML DTD Matching using Fuzzy Similarity Measure." International Journal of Fuzzy Logic and Intelligent Systems 3, no. 1 (June 1, 2003): 32–36. http://dx.doi.org/10.5391/ijfis.2003.3.1.032.

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Ahonen, H., H. Mannila, and E. Nikunen. "Generating grammars for SGML tagged texts lacking DTD." Mathematical and Computer Modelling 26, no. 1 (July 1997): 1–13. http://dx.doi.org/10.1016/s0895-7177(97)00100-3.

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Schön, Marian, Jakob Simeth, Paul Heinrich, Franziska Görtler, Stefan Solbrig, Tilo Wettig, Peter J. Oefner, Michael Altenbuchinger, and Rainer Spang. "DTD: An R Package for Digital Tissue Deconvolution." Journal of Computational Biology 27, no. 3 (March 1, 2020): 386–89. http://dx.doi.org/10.1089/cmb.2019.0469.

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Leonardi, Erwin, Tran T. Hoai, Sourav S. Bhowmick, and Sanjay Madria. "DTD-Diff: A change detection algorithm for DTDs." Data & Knowledge Engineering 61, no. 2 (May 2007): 384–402. http://dx.doi.org/10.1016/j.datak.2006.06.003.

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Amini, Sahar, Kwonhue Choi, and Dongjun Na. "Analysis of Distributed Transmit Diversity with Outdated Diversity Weights." Mobile Information Systems 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/7473839.

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Distributed transmit diversity (DTD) technique that combines cooperative communications and diversity techniques is a suitable solution in 5th-generation (5G) systems. In this paper, we investigate the effect of receiver phase compensation (RPC) on the performance of DTD. We introduce new expressions for the average error rate of DTD in the presence of RPC. The derived expressions are useful for a large number of modulation schemes. We obtain further insights by comparing the RPC effect on DTD with different spatially correlated collocated transmit diversity (CTD). The new observations include the following: (1) In the case of feedback delay, the phase compensation (PC) is required on the receiver side in addition to the transmitter side. (2) In DTD with RPC, the system performance is improved by increasing the differences between the channel gain variances. However, this is the opposite of the case of DTD without RPC. (3) The correlated CTD is more sensitive to RPC than DTD. This sensitivity increases by enhancing the correlation between transmit (TX) antennas. (4) In the case where there is no delay for CTD or DTD, RPC does not affect the system’s performance.

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Härkönen, Helmi, Petra Loid, and Outi Mäkitie. "SLC26A2-Associated Diastrophic Dysplasia and rMED—Clinical Features in Affected Finnish Children and Review of the Literature." Genes 12, no. 5 (May 11, 2021): 714. http://dx.doi.org/10.3390/genes12050714.

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Diastrophic dysplasia (DTD) is a rare osteochondrodysplasia characterized by short-limbed short stature and joint dysplasia. DTD is caused by mutations in SLC26A2 and is particularly common in the Finnish population. However, the disease incidence in Finland and clinical features in affected individuals have not been recently explored. This registry-based study aimed to investigate the current incidence of DTD in Finland, characterize the national cohort of pediatric subjects with DTD and review the disease-related literature. Subjects with SLC26A2-related skeletal dysplasia, born between 2000 and 2020, were identified from the Skeletal dysplasia registry and from hospital patient registry and their clinical and molecular data were reviewed. Fourteen subjects were identified. Twelve of them were phenotypically classified as DTD and two, as recessive multiple epiphyseal dysplasia (rMED). From the subjects with available genetic data, 75% (9/12) were homozygous for the Finnish founder mutation c.-26+2T>C. Two subjects with rMED phenotype were compound heterozygous for p.Arg279Trp and p.Thr512Lys variants. The variable phenotypes in our cohort highlight the wide spectrum of clinical features, ranging from a very severe form of DTD to milder forms of DTD and rMED. The incidence of DTD in Finland has significantly decreased over the past decades, most likely due to increased prenatal diagnostics.

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Choe, Gui-Ja, and Young-Kwang Nam. "Skeleton Code Generation for Transforming an XML Document with DTD using Metadata Interface." KIPS Transactions:PartD 13D, no. 4 (August 1, 2006): 549–56. http://dx.doi.org/10.3745/kipstd.2006.13d.4.549.

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Ford, Julian D. "Progress and Limitations in the Treatment of Complex PTSD and Developmental Trauma Disorder." Current Treatment Options in Psychiatry 8, no. 1 (February 9, 2021): 1–17. http://dx.doi.org/10.1007/s40501-020-00236-6.

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Abstract Purpose of review This review describes treatments that have been developed (or adapted from treatment models for posttraumatic stress disorder [PTSD]) for Complex PTSD (cPTSD) in adulthood and developmental trauma disorder (DTD) in childhood. The nascent research evidence-base is reviewed and future directions are discussed. Recent findings Numerous psychotherapy treatments are in the early stages of clinical testing and dissemination for symptoms of cPTSD (emotion dysregulation, interpersonal detachment, altered self-perception) and the additional symptoms of DTD (interpersonal, somatic, and behavioral dysregulation and dissociation). There is indirect evidence, primarily based on reductions in depression and anxiety symptoms (but not cPTSD or DTD symptoms specifically), of efficacy for varied approaches to trauma-focused cognitive behavior therapy (CBT) in randomized controlled trials with adults and children with histories of developmentally adverse traumatic childhood experiences (e.g., abuse, violence). No approaches to pharmacotherapy have been systematically developed or tested for adult cPTSD or childhood DTD. Summary Despite a rapidly growing array of promising approaches to psychotherapy for cPTSD and DTD, the absence of formal diagnostic criteria for cPTSD and DTD has limited efforts to conduct scientific evaluations of the efficacy of these treatments. As treatment models continue to be created, refined, and disseminated, the recent development and validation of psychometric assessment measures for cPTSD (the International Trauma Questionnaire; ITQ) and DTD (the Developmental Trauma Disorder Semi-structured Interview; DTD-SI) is a crucial catalyst for rigorous outcome research that can lead to a robust cPTSD and DTD treatment outcome evidence-base and a precision health approach to treatment.

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Martínez-Poveda, Beatriz, Ramón Muñoz-Chápuli, Ricardo Riguera, Antonio Fernández, Miguel Ángel Medina, and Ana R. Quesada. "DTD, an anti-inflammatory ditriazine, inhibits angiogenesisin vitroandin vivo." Journal of Cellular and Molecular Medicine 12, no. 4 (August 2008): 1211–19. http://dx.doi.org/10.1111/j.1582-4934.2008.00147.x.

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Liu, Mengchi. "DTD schema: a simple but powerful XML schema language." International Journal of Web Information Systems 4, no. 4 (November 21, 2008): 465–83. http://dx.doi.org/10.1108/17440080810919495.

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Ozel, Mustafa Z., Selcen Yilmaz, and Cagri Ergin. "Analysis ofEucalyptus camaldulensisVolatiles from Turkey Using DTD-GC-MS." Journal of Essential Oil Bearing Plants 13, no. 3 (January 2010): 297–312. http://dx.doi.org/10.1080/0972060x.2010.10643825.

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Calvo, Antonio M. "Structuring biographical data in EAD with the Nomen DTD." OCLC Systems & Services: International digital library perspectives 17, no. 4 (December 2001): 187–99. http://dx.doi.org/10.1108/10650750110409380.

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Freundlich, Jonathan, and Dan Maoz. "The delay time distribution of Type-Ia supernovae in galaxy clusters: the impact of extended star-formation histories." Monthly Notices of the Royal Astronomical Society 502, no. 4 (February 20, 2021): 5882–95. http://dx.doi.org/10.1093/mnras/stab493.

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ABSTRACT The delay time distribution (DTD) of Type-Ia supernovae (SNe Ia) is important for understanding chemical evolution, SN Ia progenitors, and SN Ia physics. Past estimates of the DTD in galaxy clusters have been deduced from SN Ia rates measured in cluster samples observed at various redshifts, corresponding to different time intervals after a presumed initial brief burst of star formation. A recent analysis of a cluster sample at z = 1.13–1.75 confirmed indications from previous studies of lower redshift clusters, that the DTD has a power-law form, DTD(t) = R1(t/Gyr)α, with amplitude R1, at delay $t=1\,\rm Gyr$, several times higher than measured in field-galaxy environments. This implied that SNe Ia are somehow produced in larger numbers by the stellar populations in clusters. This conclusion, however, could have been affected by the implicit assumption that the stars were formed in a single brief starburst at high z. Here, we re-derive the DTD from the cluster SN Ia data, but relax the single-burst assumption. Instead, we allow for a range of star-formation histories and dust extinctions for each cluster. Via MCMC modelling, we simultaneously fit, using stellar population synthesis models and DTD models, the integrated galaxy-light photometry in several bands, and the SN Ia numbers discovered in each cluster. With these more-realistic assumptions, we find a best-fitting DTD with power-law index $\alpha =-1.09_{-0.12}^{+0.15}$, and amplitude $R_1=0.41_{-0.10}^{+0.12}\times 10^{-12}\,{\rm yr}^{-1}\, {\rm M}_\odot ^{-1}$. We confirm a cluster-environment DTD with a larger amplitude than the field-galaxy DTD, by a factor ∼2–3 (at 3.8σ). Cluster and field DTDs have consistent slopes of α ≈ −1.1.

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TOKIZANE, Soichi, Go IZUI, Yuji KONDO, Kazuki TSURUGAI, Osamu MIKAMI, Koichi NOZAWA, Kazuhiko HORIUCHI, et al. "From NLM DTD to JATS : XML for scholarly articles in Japanese." Journal of Information Processing and Management 54, no. 9 (2011): 555–67. http://dx.doi.org/10.1241/johokanri.54.555.

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Zhang, Xue Min, Zeng Gang Xiong, and Cong Huan Ye. "An Improved XOS Dealing with Nested Loop." Applied Mechanics and Materials 411-414 (September 2013): 390–93. http://dx.doi.org/10.4028/www.scientific.net/amm.411-414.390.

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Propose a model extraction approach to abstract the DTD document rapidly, and to eliminate the nested ring in DTD document by using redefining the node name. Map the DTD document that removing ring out to XML document. Analyzes the XQuery query, and does the responding pre-processing, realizes the XQuery program with nested ring structure.

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Barclay, Sarah F., Kendra Potocki, Ford Burles, N. Torben Bech-Hansen, and Giuseppe Iaria. "Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation." Journal of Alzheimer's Disease Reports 5, no. 1 (July 19, 2021): 565–70. http://dx.doi.org/10.3233/adr-210304.

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The three common alleles of the APOE gene, ɛ2/ɛ3/ɛ4, have been linked to human spatial orientation. We investigated the genetic role of APOE in developmental topographical disorientation (DTD), a lifelong condition that results in topographical disorientation. We genotyped the APOE ɛ2/ɛ3/ɛ4 alleles in a cohort of 20 unrelated DTD probands, and found allele frequencies not statistically different from the those seen in the population as a whole. Therefore, we found no evidence that DTD occurs preferentially on a genetic background containing any particular APOE allele, making it unlikely that these APOE alleles are contributing to the development of DTD.

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Mok, Wai Yan, Joseph Fong, and Kenneth Wong. "Designing Redundancy-Free XML Schema: A Smallest Closure Approach." International Journal of Cooperative Information Systems 24, no. 04 (December 2015): 1550005. http://dx.doi.org/10.1142/s0218843015500057.

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XML has too many low-level details that hinder high-level conceptual design. We therefore propose DTD graphs and XSD graphs as a mean for conceptual modeling of XML applications. Similar to document type definitions (DTDs) and XML schema definitions (XSDs), DTD graphs and XSD graphs are trees, and as such they can easily be mapped to DTDs and XSDs for implementation. Unlike DTDs and XSDs, DTD graphs and XSD graphs capture various high-level data semantics such as cardinality, ISA, participation, aggregation, categorization, and n-ary relationship. Furthermore, this paper also presents transformation rules between DTDs and a large class of XML Schemas and an algorithm that inputs users’ requirements and outputs a DTD graph that has a minimum number of redundancy-free fragments. As a result of these good properties, the resulting DTD or XSD facilitates query processing and update.

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Pesic, Vesna, Milena Becelic-Tomin, Bozo Dalmacija, and Dejan Krcmar. "Impact assessment wastewater discharge on water quality DTD canal Becej-Bogojevo." Chemical Industry 69, no. 3 (2015): 219–29. http://dx.doi.org/10.2298/hemind140204035p.

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Pressure and impact analysis requires information on the main drivers and changes in conditions. In order to analyze such pressures and impacts, each river basin requires: an analysis of its characteristics, a review of the impact of human activity on the status of the surface water and an economic analysis of water use. Pressure and impact analysis plays a central role in the planning of river basin management. The quality of the stream at any point depends on several major factors: lithology of the basin, weather conditions, climate, and human impacts. Most of the polluters are located in the big cities next to canal DTD Becej-Bogojevo canal (Odzaci,Vrbas, Srbobran, Becej). Per year, 2900000 m3 of wastewater was discharged into the Becej-Bogojevo section of the DTD canal: 1,4 tCOD, 0,8 0tBOD, 260 kg of nitrogen, 19 kg of phosphorus and 282 kg of suspended solids. Of the total volume of wastewater, 20% comes from industry and 80% from municipal wastewater. Most of the wastewaters from the studied polluters is discharged untreated or insufficiently treated (only primary treatment). This poor quality wastewater threatens the receipients into which its is discharged. Comparison of the wastewater quality results to the Decree on emission limits and deadlines for their achievement, shows that many polluters exceed the limits for all parameters (COD, BOD, nitrogen, phosphorus, suspended solids). On the basis of the physico-chemical analysis of the water from the DTD Becej-Bogojevo canal it can be concluded that the water quality is unsatisfactory. According to the national legislation, the water quality exceeds the values for good potential streams for most parameters at all sampling locatio dissolved oxygen, organic matter and nutrients). Thus, we can conclude that the water in the studied section of the DTD Becej-Bogojevo canal does not meet the criteria for "good ecological potential". The most vulnerable locations are downstream of the Vrbas and downstream of the Becej, while the best quality canal water is at the furthest upstream location (CS Bogojevo). Risk assessment based on monitoring results indicates that the water of the studied section of the DTD Becej-Bogojevo canal is probably at risk of failing to meet the objectives of the Water Framework Directive, as 33% of the analyzed parameters to calculate specific risk ratios were greater than 1, and thus fall into the category of pollutants medium risk. In order to achieve the quality (to achieve good status and good potential), there must be a response from industrial producers, which consists primarily of comprehensively understanding the problems and implementing measures to minimize the impact of these problems.

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Moebus, Volker, Hans-Joachim Lueck, Ekkehart Ladda, Peter Klare, Marcus Schmidt, Andreas Schneeweiss, Michael Untch, et al. "GAIN-2: Neo-/adjuvant phase III trial to compare intense dose-dense chemotherapy (CT) to tailored dose-dense CT in patients (pts) with high risk early breast cancer (EBC): Results on safety and interim invasive disease-free survival (iDFS)." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 516. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.516.

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516 Background: GAIN-2 (NCT01690702) compared efficacy and safety of intense, dose-dense epirubicin, nab-paclitaxel, and cyclophosphamide (iddEnPC) vs dose-dense, dose-tailored epirubicin/ cyclophosphamide followed by dose-dense, dose-tailored docetaxel (dtEC-dtD) as adjuvant or neoadjuvant CT for node-positive or high risk node-negative EBC. Here, we report safety results and interim analysis (IA) of the primary endpoint iDFS. Methods: Pts (luminal A ≥N2; luminal B N+; HER2+ and TNBC) were randomized between iddEnPC (E 150 mg/m2, nP 330 mg/m2, C 2000 mg/m2, all q2w x 3) or dtEC-dtD (dtEC q2w x 4 followed after 1 week rest by dtD q2w x 4). Primary objective was to compare iDFS. 797 events are needed to detect a hazard ratio of 0.819 with a 2-sided log-rank-test with 80% power and α=0.05. The IA of iDFS was planned after 50% of the events have occurred. Safety and compliance were secondary objectives. Results: Between 10/2012 and 09/2018, 2887 pts were randomized and 2857 started treatment (iddEnPC 1429; dtEC-dtD 1428). Median age was 51 (range 18-75) years. Overall, 18.1% were luminal A, 31.5% luminal B/HER2-, 18.8% hormone-receptor (HR)+/HER2+, 8.5% HR-/HER2+ and 23.2% TNBC. Overall, 88.1% of pts completed all treatment in both arms. 66.8% with iddEnPC vs 58.8% with dtEC-dtD delayed CT dose (p<0.001). Grade 3-4 non-hematological adverse events (AEs) were more frequent with iddEnPC (iddEnPC 50.8% vs dtEC-dtD 45.1%, p=0.002). Grade 3-4 leukopenia, neutropenia, febrile neutropenia, arthralgia, and peripheral sensory neuropathy were significantly higher with iddEnPC. There were 1464 serious AEs (iddEnPC 870 vs dtEC-dtD 594) and 26 (9 vs 17) predefined AEs of special interest (anaphylaxis, any AE affecting cranial nerves, macula edema). Two deaths occurred during dtEC-dtD. After a median follow-up of 45.8 months, there was no difference in iDFS between arms (log-rank p=0.9102, hazard ratio iddEnPC vs dtEC-dtD 1.01, 95% CI 0.83-1.23). Conclusions: No new safety concerns were observed. Use of both iddEnPC and dtEC-dtD appears feasible in the (neo)adjuvant treatment of high risk EBC. Clinical trial information: NCT01690702 .

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Zappa, F., and F. Cavalli. "NAD(P)H:quinone oxidoreductase 1 expression in human primary melanotic melanomas of the skin." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 18018. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.18018.

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18018 NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a two-electron reducing enzyme which is often over-expressed in cancers and can activate quinones to form cytotoxic species. This over-expression is used as target in the design of novel anti-cancer drugs. DTD is also expressed in normal tissues, but little is known about its “body mapping”. Because of the dearth of information on the cell-specific expression of DTD in pigment-producing cells of the skin, we analysed its expression in normal and tumoral samples. Twenty skin biopsies of primary malignant melanotic melanomas (ten with vertical invasion, ten with superficial spreading) were analysed by immunohistochemistry. In normal skin DTD expression was weak in all epidermal layers, including normal melanocytes. Malignant melanomas showed a very strong DTD expression in tumoral cells of all samples and in endothelial lining of peri-tumoral vessels. These results suggest that DT-diaphorase may be a new marker that could be useful in determining the extent of a malignant melanocytic lesion, and also tend to support the potential of malignant melanomas as target for DTD-directed antitumour agents. No significant financial relationships to disclose.

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Rho, Myung Ho, and Dong Wook Kim. "Computed Tomography Features of Incidentally Detected Diffuse Thyroid Disease." International Journal of Endocrinology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/921934.

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Objective. This study aimed to evaluate the CT features of incidentally detected DTD in the patients who underwent thyroidectomy and to assess the diagnostic accuracy of CT diagnosis.Methods. We enrolled 209 consecutive patients who received preoperative neck CT and subsequent thyroid surgery. Neck CT in each case was retrospectively investigated by a single radiologist. We evaluated the diagnostic accuracy of individual CT features and the cut-off CT criteria for detecting DTD by comparing the CT features with histopathological results.Results. Histopathological examination of the 209 cases revealed normal thyroid (n=157), Hashimoto thyroiditis (n=17), non-Hashimoto lymphocytic thyroiditis (n=34), and diffuse hyperplasia (n=1). The CT features suggestive of DTD included low attenuation, inhomogeneous attenuation, increased glandular size, lobulated margin, and inhomogeneous enhancement. ROC curve analysis revealed that CT diagnosis of DTD based on the CT classification of “3 or more” abnormal CT features was superior. When the “3 or more” CT classification was selected, the sensitivity, specificity, positive and negative predictive values, and accuracy of CT diagnosis for DTD were 55.8%, 95.5%, 80.6%, 86.7%, and 85.6%, respectively.Conclusion. Neck CT may be helpful for the detection of incidental DTD.

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Treadwell, Wendy. "Maximizing the Search Potential of Social Science Codebooks Through the Application of the Codebook DTD." IASSIST Quarterly 23, no. 4 (April 30, 2000): 10. http://dx.doi.org/10.29173/iq851.

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Zhang, Wenjie, Siming Yang, Shuai Heng, Ximei Gao, Yan Wang, Wenxiang Zhang, Qunting Qu, and Honghe Zheng. "Improved solid electrolyte interphase and Li-storage performance of Si/graphite anode with ethylene sulfate as electrolyte additive." Functional Materials Letters 13, no. 07 (October 2020): 2051041. http://dx.doi.org/10.1142/s1793604720510418.

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Silicon/graphite composite anodes have drawn extensive attention in the field of power Li-ion batteries for application in electric vehicles because of their much higher capacity than that of traditional graphite anodes. In this work, ethylene sulfate (1,3,2-dioxathiolane-2,2-dioxide, DTD) is investigated as an electrolyte additive to improve the Li-storage performance of silicon/graphite composite anode. The electrochemical behavior of silicon/graphite anode including cyclic voltammogram, discharge/charge performance at various current density and during long-term cycling, and electrochemical impedance is systematically studied by adding different amounts of DTD into electrolyte. The effects of DTD on the solid/electrolyte interphase (SEI) film are analyzed through scanning electron microscopy, X-ray photoelectron and Fourier transform infrared spectroscopy. It is found that DTD participates into the film-formation process through its reductive decomposition reactions on electrode surface, producing a thin, uniform and stable SEI. The Li-storage performance of silicon/graphite anode is improved at an optimized addition amount of DTD.

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Planelles, G., F. Discala, and T. Anagnostopoulos. "Luminal pH in the amphibian distal tubule: effects of carbonic anhydrase and carbonic anhydrase inhibitors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 263, no. 6 (December 1, 1992): R1254—R1259. http://dx.doi.org/10.1152/ajpregu.1992.263.6.r1254.

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To better delineate acid-base transport properties in the distal tubule (DT) of Necturus in vivo, we 1) studied the effects of peritubular (pt) isohydric increase of PCO2 and [HCO3-]pt on luminal pH (pHlu), and 2) measured the steady-state pHlu under various experimental conditions. The experiments were carried out on initial (DTi) or distal (DTd) loops of the DT in control state and then during intravenous infusion of carbonic anhydrase (CA) or CA inhibitors (CAI). In control state, isohydric increase of PCO2 and [HCO3-]pt results in transient acidification of the DTi lumen, whereas in DTd lumen the same maneuver yields sustained (plateau) acidification. Under systemic infusion of CAI, isohydric increase of PCO2 and [HCO3-]pt lowers pHlu (sustained fall of pHlu) in DTi and DTd, whereas under CA infusion both segments exhibit only transient acidification. During intravenous infusion with benzolamide DTi steady-state pHlu falls, suggesting that this maneuver inhibits a functional luminal CA, in contrast to the DTd, whose pHlu remains unaltered. Intravenous infusion of CA significantly increases steady-state DTd pHlu; by contrast, steady-state pHlu in DTi does not change. These data are consistent with the presence of functional luminal CA in the DTi, whereas the DTd segment lacks the luminal enzyme.

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Hidayatin, Umi. "PENERAPAN TEKNIK COGNITIVE RESTRUCTURING UNTUK MENGURANGI GEJALA DISSOCIATIVE TRANCE DISORDER SISWA SMAN 1 KADEMANGAN." CENDEKIA: Journal of Education and Teaching 11, no. 1 (January 14, 2017): 45. http://dx.doi.org/10.30957/cendekia.v11i1.250.

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This study described Cognitive Restructuring (CR) to reduce simthompts of Dissociate Trance Disorder (DTD) in the rehearsals process on athletic activities and how CR increased cognitive process to reasoning, understanding and reducing DTD. This study used classroom action research design with two cycles. The study was conducted in SMAN 1 Kademangan, Blitar. The study revealed that CR improved students skills to reduce DTD that raised internally through physical activities or mentally through thinking process.

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Choe, Mun-Yeong, and Gyeong-Su Ju. "Transformation from XML DTD to OODB Schema using Object Model." KIPS Transactions:PartD 9D, no. 2 (April 1, 2002): 195–202. http://dx.doi.org/10.3745/kipstd.2002.9d.2.195.

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Qin, Long, Quanjun Yin, Yabing Zha, and Yong Peng. "Dynamic Detection of Topological Information from Grid-Based Generalized Voronoi Diagrams." Mathematical Problems in Engineering 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/438576.

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In the context of robotics, the grid-based Generalized Voronoi Diagrams (GVDs) are widely used by mobile robots to represent their surrounding area. Current approaches for incrementally constructing GVDs mainly focus on providing metric skeletons of underlying grids, while the connectivity among GVD vertices and edges remains implicit, which makes high-level spatial reasoning tasks impractical. In this paper, we present an algorithm named Dynamic Topology Detector (DTD) for extracting a GVD with topological information from a grid map. Beyond the construction and reconstruction of a GVD on grids, DTD further extracts connectivity among the GVD edges and vertices. DTD also provides efficient repair mechanism to treat with local changes, making it work well in dynamic environments. Simulation tests in representative scenarios demonstrate that (1) compared with the static algorithms, DTD generally makes an order of magnitude improvement regarding computation times when working in dynamic environments; (2) with negligible extra computation, DTD detects topologies not computed by existing incremental algorithms. We also demonstrate the usefulness of the resulting topological information for high-level path planning tasks.

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ZHANG, Jian-mei, and Shi-qun TAO. "Check on consistency of tree pattern queries under DTD constraints." Journal of Computer Applications 28, no. 11 (June 5, 2009): 2961–63. http://dx.doi.org/10.3724/sp.j.1087.2008.02961.

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Singh, Nanhay, R. K. Chauhan, and Raghuraj Singh. "Inference Document Type (Dtd) From Xml Document: Web Structure Mining." International Journal of Computer Applications 7, no. 9 (October 10, 2010): 6–9. http://dx.doi.org/10.5120/1280-1645.

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Routh, Satya Brata, and Rajan Sankaranarayanan. "Enzyme action at RNA–protein interface in DTD-like fold." Current Opinion in Structural Biology 53 (December 2018): 107–14. http://dx.doi.org/10.1016/j.sbi.2018.07.013.

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Hästbacka, Johanna, Anne Kerrebrock, Kati Mokkala, Gregory Clines, Michael Lovett, Ilkka Kaitila, Albert de la Chapelle, and Eric S. Lander. "Identification of the Finnish founder mutation for diastrophic dysplasia (DTD)." European Journal of Human Genetics 7, no. 6 (September 1999): 664–70. http://dx.doi.org/10.1038/sj.ejhg.5200361.

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Journal articles on the topic 'DTD'

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