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Journal articles on the topic 'Drum accompanying'

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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Faith, Rhema, and Panji Suroso. "The Technique of Bebano Drums on Accompanying Jogi Dance in Wansendari Art Studio Batam City." Grenek Music Journal 10, no. 2 (September 21, 2021): 17. http://dx.doi.org/10.24114/grenek.v10i2.27615.

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The purpose of this study is: To find out how the technique of playing Gendang Bebano in accompanying the jogi dance in the wansendari art studio. The approach and type of research used by the researcher is descriptive qualitative. This research was conducted at the Wansendari Art Studio, Batam City, so the population of this study were all members of the Wansendari Art Studio. While the samples of this study were members of the studio musicians, the head of the studio, the instructor of the studio as well as the head of culture in the city of Batam. The writing uses data collection techniques in the form of: observation to produce valid data regarding the technique of playing the Gendang Bebano in accompanying the jogi dance. Interview to get the results of research on the technique of playing Gendang Bebano in accompanying the jogi dance. Documentation for additional data in the form of photos, recordings and videos. The results of this study prove that the technique of playing the Gendang Bebano in the form of the body position of the drummers is sitting cross-legged and the drums are above the players' feet The Bebano of the drum is held by both players' hands and produces the sound of tak, pung, plang, tung. On the sound without using the index finger, middle finger, third finger, and little fingers, they are hit on the edge of the drum skin. The sound of pung uses the index finger, middle finger, third finger, and little finger but is hit in the middle area of the drum with the fingers in a straight position with the palm of the hand attached to the edge of the drum. In the plaang sound, the middle finger, third finger, and little finger are beaten on the edge of the drum but the palms are attached to the circumference of the drum. For the tung sound, use 4 straight fingers and hit in the middle of the drum.
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2

Dewi, Cicilia Dikna Astrina, and Suharto Suharto. "Musical Development Of Barongan Turonggo Laras Through Additional Instrument In Kendal Regency." Jurnal Seni Musik 10, no. 1 (June 30, 2021): 86–92. http://dx.doi.org/10.15294/jsm.v10i1.46058.

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This study aims to determine, describe, and analyze the development of the Barongan work of the Turonggo Laras group in Kendal Regency. The method used is descriptive qualitative with a musicological approach. Data collection techniques include observation, interviews, and documentation. The results showed that the development of working on Barongan Turonggo Laras music was in the form of adding western musical instruments, such as drums and keyboards in collaboration with gamelan. The use of the keyboard is intended as a filler for the main melody in campursari songs. This is because there are tones in the campursari song that does not exist on the gamelan instrument but exist on the keyboard. The addition of drums in the show is intended to lift the mood and strengthen the trance scene. The drum play tends to follow the dynamics of the kendang when accompanying the performance.
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3

Bottau, V., L. Tondut, P. G. Allinei, B. Perot, C. Eleon, C. Carasco, R. De Stefano, and G. Faussier. "Study of gamma-ray background noise for radioactive waste drum characterization with plastic scintillators." EPJ Web of Conferences 225 (2020): 05004. http://dx.doi.org/10.1051/epjconf/202022505004.

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In the framework of the radioactive waste drum characterization using neutron coincidence counting, the Nuclear Measurement Laboratory of CEA Cadarache is studying plastic scintillators as an alternative to ideal but costly 3He gas proportional counters. Plastic scintillators are at least 5 times cheaper for the same detection efficiency, and in addition, they detect fast neutrons about three orders of magnitude faster than 3He detectors. However, they are sensitive to gamma rays, which implies the necessity to identify precisely gamma background sources that may affect the useful signal. This paper presents a detailed analysis of the gamma-ray spectrum of a radioactive waste drum containing glove box filters contaminated by plutonium dioxide. Gamma emissions accompanying inelastic scattering (n,n’) and (α,n) reactions that can lead to neutron-gamma coincidences parasitizing useful coincidences from plutonium spontaneous fissions are identified. Some of these parasitic gamma rays having energies up to several MeV, we plan to reject high-energy scintillator pulses with an electronics rejection threshold above 1 MeV, which should preserve the major part of useful fission neutron pulses.
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4

Bito, Gregorius Sebo, and Fredy Fredy. "ETHNOMATHEMATICS: MUSICAL INSTRUMEN IN JA'I DANCES FOR CULTURALLY RESPONSIVE TEACHING IN ELEMENTARY SCHOOLS." PrimaryEdu - Journal of Primary Education 4, no. 2 (September 30, 2020): 183. http://dx.doi.org/10.22460/pej.v4i2.1853.

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In cultural responsive learning, teachers need to have the ability to explore mathematical phenomena in cultural elements as learning content. This research is a qualitative descriptive study aimed at exploring ethnomathematics in Bajawa traditional dances, namely the Ja,i dance, its relevance to competency standards and basic mathematics competencies in elementary schools. The approach used is ethnographic. The technique used is observation and study of documents and the researcher himself acts as the main instrument. Observations were made on the accompanying music devices contained mathematical concepts. Furthermore, researchers compare with the basic competencies of elementary school mathematics. The results showed mathematical material was found in the musical instrument section of Ja,i dance. The surface of the gong and the drum (gendang) are circular, the body of the large drum is frustum of a cone, and the gendang laba kagu, laba bhuga and gong are tube-shaped. In the middle of the gong there is a kind of lump which is shaped like a half ball. The implementation of this research can be applied in cultural responsive learning in elementary schools.Keywords: ethnomathematics, learning, cultural responsive, jai,i dance
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5

Sudirana, I. Wayan. "Improvisation in Balinese Music: An Analytical Study of Three Different Types of Drumming in the Balinese Gamelan Gong Kebyar." Journal of Music Science, Technology, and Industry 1, no. 1 (August 31, 2018): 1. http://dx.doi.org/10.31091/jomsti.v1i1.502.

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ABSTRACTGong kebyar emerged in early 20th century and was initially an instrumental genre. In its later advancement, the ensemble became accustomed to accompanying dance compositions, which are decorated with miscellaneous dance improvisations corresponding to the characteristic style of gong kebyar. There are three types of Balinese drumming that are considered improvisational, in particular the styles that are played in the repertory of gamelan gong kebyar. Gamelan gong kebyar is the most popular and influential genre of twentieth century music developed in Bali. In gamelan baru, the function of the drum (in Bali it is called kendang) in the ensemble is more important than it was in older styles and it is considered to be the leader of the ensemble. Drummers are skilled musicians and usually teachers, who know all of the parts that are played by other instruments in the ensemble. Krumpungan, Cedugan, and Gupekan are examples of drumming style that gives incorporate the idea of improvisation, though in Bali we do not have a special term for improvisation. We do however have the same ideas and sense of the meaning of improvisation itself in the way some drumming is played spontaneously in the course of performance, by using drummer’s abilities to create spontaneously new pattern on stage. There are some important aspects that need to be underlined in creating those patterns, such as: melody accompaniment, dancer’s cues, good partnership (in krumpungan and cedugan), and the ability to lead the ensemble. Those aspects have the prominent role in the acheivement of drum improvisation in the performance. Drumming improvisation remains something that has to be learned more comprehensively in the future. It is still an abstract concept for many musicians as well as Balinese gamelan lovers.Keywords: improvisation, drumming, kendang, gong kebyar. ABSTRAKGong kebyar muncul pada awal abad ke-20 dan pada mulanya merupakan genre instrumental. Dalam perkembangan selanjutnya, ensambel tersebut menjadi terbiasa dengan komposisi tari yang menyertainya, yang dihiasi dengan improvisasi tari yang berbeda sesuai dengan gaya khas gong kebyar. Ada tiga jenis drum Bali yang dianggap improvisasi, khususnya gaya-gaya yang dimainkan dalam repertoar gamelan gong kebyar. Gamelan gong kebyar adalah genre musik abad ke-20 yang paling populer dan berpengaruh yang dikembangkan di Bali. Dalam gamelan baru ini, fungsi drum (di Bali disebut kendang) dalam ensambel lebih penting daripada pada gaya lama dan dianggap sebagai pemimpin ensembel. Drumer adalah musisi yang terampil dan biasanya adalah guru, yang tahu semua bagian yang dimainkan oleh instrumen lain dalam ensembel. Krumpungan, Cedugan, dan Gupekan adalah contoh gaya drum yang memberikan ide improvisasi, meskipun di Bali tidak ada istilah khusus untuk improvisasi. Namun di sini ada ide yang sama dan rasa makna improvisasi itu sendiri dengan cara memainkan beberapa drum secara spontan dalam jalannya pertunjukan, dengan menggunakan kemampuan pemain drum untuk menciptakan pola spontan baru di panggung. Ada beberapa aspek penting yang perlu digarisbawahi dalam menciptakan pola-pola tersebut, seperti: iringan melodi, isyarat penari, kemitraan yang baik (dalam krumpungan dan cedugan), dan kemampuan untuk memimpin ensambel. Aspek-aspek tersebut memiliki peran penting dalam pencapaian improvisasi drum dalam pettunjukan. Improvisasi drum tetap sesuatu yang harus dipelajari lebih komprehensif di masa depan. Ini masih merupakan konsep abstrak bagi banyak musisi dan juga pecinta gamelan Bali. Kata kunci: improvisasi, drum, kendang, gong kebyar.
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6

Fitri, Putri Ariska, Jagar Lumbantoruan, and Irdhan Epria Darma Putra. "ARANSEMEN LAGU AYAH." Jurnal Sendratasik 8, no. 3 (February 11, 2019): 9. http://dx.doi.org/10.24036/jsu.v7i3.103277.

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AbstractThe purpose of this work is to arrange Ayah song as a form of expression of the author's musical experience in arranging, making musical arrangements that are relevant to the works of musical works of students and maximizing the potential of human resources (students) in school. In this work, the author uses a mixed ensemble presentation format. The musical instruments used for accompanying vocals are pianika, piano, guitar, bass, and drum-set. This arrangement uses 2 parts, namely part A and part B with a time signature of 4/4. Part A starts from 1 time to 46 time and part B starts from the time of 47 to 103. The musical arrangement of this work contains lyrics that tell about the attitude of a father who loves and protects his child. The development techniques applied are (1) repetition melodically and rhythmically, (2) sequences, (3) augmentation, (4) diminution, and various other techniques without changing the essence of the song Ayah.Keywords: Arrangement, School Music, Father's Song.
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7

Pramudya, Nicolas Agung. "Penciptaan Karya Komposisi Musik Sebagai Sebuah Penyampaian Makna Pengalaman Empiris Menjadi Sebuah Mahakarya." Gelar : Jurnal Seni Budaya 17, no. 1 (August 6, 2019): 14–23. http://dx.doi.org/10.33153/glr.v17i1.2597.

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ABSTRAK Komposisi Musik “Katur Ibu” adalah komposisi musik yang ide penggarapannya berangkat dari sebuah cinta, pengorbanan dan kasih sayang yang dikemas dengan format tradisi dan modern menghadirkan warna baru dalam komposisi penciptaan, yang membentuk sebuah karya musik yang utuh. Jenis karya seni tidak menata pada kejadian menurut alur yang sebenarnya akan tetapi lebih kepada suasana yang mendukung. Komposisi musik “Katur Ibu” terdiri dari 5 bentuk utama dengan menggunakan tempo Allegro, moderato, adagio, andante, dan vivance, yang dapat menggambarkan suasana tenang, sedih, gembira dan semangat, pengkarya maknai sebagai guratan sisi pandang terhadap realita yang terlintas dalam fikiran pengkarya seperti emosi penyesalan, kegamangan, ketulusan dan impian. Penyajian komposisi musik “Katur Ibu” memakai beberapa instrument pokok dan intrumen pendukung yaitu, Piano sebagai melodi utama, flute, bass elektrik, drum pad DTX, saron, bonang, kendang Sunda dan keyboard sebagai Accompainement dalam komposisi musik yang dikemas dalam konsep pertunjukan ini. Kata kunci: Komposisi, pengalaman empiris, Katur Ibu. ABSTRACT “Katur Ibu” Music Composition is a musical composition which the cultivation ideas depart from a love, sacrifice and affection that is packaged in a traditional and modern format presenting a new color in the composition of creation, which forms a complete musical work. types of artworks do not arrange the events according to the actual plot but rather to the atmosphere that supports it. The musical composition “Katur Ibu” consists of 5 main forms using tempo Allegro, moderato, adagio, andante, and vivance, which can describe the atmosphere of calm, sadness, joy and enthusiasm. The composer means as a side view of reality that comes to mind such as emotions of regret, anxiety, sincerity and dreams. The presentation of “Katur Ibu” music composition uses several basic instruments and accompanying instruments, including, Piano as the main melody, flute, electric bass, DTX drum, saron, bonang, Sundanese drum and keyboard as Accompainement in the musical composition that is packaged for the show. Keywords: Composition, empirical experience, Katur Ibu.
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8

Fámúlẹ̀, Oláwọlé. "Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún." Yoruba Studies Review 2, no. 2 (December 21, 2021): 1–50. http://dx.doi.org/10.32473/ysr.v2i2.129886.

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Kò séní m’èdè Àyàn Bí ení mú kò ̣ ̣ǹgó ̣ è ̣ lówọ́ No one understands the language of Àyàn Better than the drummer who holds the gong in his hand Yorùbá maxim From the Yorùbá oral historical, mythological, and ontological, abstract lines of reasoning, Àyàn is believed to be the first Yorùbá drum maker and drummer, who, after his death, was deified as the god of Drumming (Òrìsà ̣ Àyàn, or simply Àyàn). Hence, when an experienced Yorùbá drummer plays his drum masterfully, the elders with the drum speech discernable ears (òmò ̣ ràn) that hear the drumming, even from afar commend, “may Àyàn, ̣ the god of drumming prosper/ protect you!” (Àyàn ó gbè ó!). As among other Yorùbá deities (òrìsạ̀) that live in the spiritual realm in certain but uncommon natural environments (forests, trees, rivers, streams, and mountains, among others), Òrìsà Àyàn is thought to reside in wood (Vil ̣ - lepastour 2015, 3). For this reason, Òrìsà Àyàn is emblematized by the wood ̣ with which the body of the drum (ìlù) is carved. Similarly, this deity is eulogized as “the spirit who speaks out from inside his wooded abode” (Òrìsà ̣ gbé’nú igi fohùn), in reference to the log of wood with which the drums (ìlù) are carved. It is said that Òrìsà Àyàn particularly prefers that ìlù be carved ̣ with Cordia millenii (igi òmò ̣ ), a belief that gave birth to the Yorùbá saying, ̣ “out of the entire wood species of the forests is the preferred Cordia millenii, with which gbèdụ drum is carved” (Igi gbogbo ní ńbe ̣ ní’gbó, k’átó fi’gi òmò ̣ ̣ gbé ̣ gbèdụ). Because of his position as the patron deity of drumming, which 2 Oláwọlé Fámúlẹ̀ by extension is used to accompanying sacred rites in honor of virtually all the Yorùbá òrìsạ̀, Òrìsà Àyàn is thought to be their mouthpiece, as they all speak ̣ through the drums that he emblematizes. Another emblem of Òrìsà Àyàn that ̣ is even worshipped is a shallow hemispherical drum with a single fixed head, which is worn on the chest with a strap around the neck and beaten with leather straps held in each hand (gúdúgúdú ) (Bascom 1952, 4). The gúdúgúdú symbol of Òrìsà Àyàn also goes by the praise name (oríkì) “gúdúgúdú with its distinctive uneven and undulated back shape” (Gúdúgúdú, ab’è yìn jákan- ̣ jàkan). The component parts that formed this uneven and surged-back shape [of gúdúgúdú] include kúseré and apìràn. Kúseré is a circular metal object affixed onto the drum’s wooded base, and apìràn is an array of wooden pegs that hold the kúseré securely onto the base of the instrument. At the exoteric and practical level, Àyàn also refers to any Yorùbá traditional and professional drummer, who plays the drum (ìlù), often with the use of a gong (kòṇ̀ gó).̣ The Yorùbá professional drummers share the name àyàn with Òrìsà Àyàn since they are the human agents who play the drums (ìlù), ̣ emblem of Òrìsà Àyàn, and through which the deity speaks. The ̣ Yorùbá incantation “the day that the drummer drums with his gong/drumstick is the very moment that the Àyàn god of drumming speaks out that which is in his mouth” (Òòjó ̣ tí kòṇ̀ gó ̣ Àyàn bá f’ojú ba ìlù ni Òrìsà Àyàn ̣ ńpo ̣ t’enu rè ̣ ̣ sí’lè) ̣ best illustrates the interconnection of the drummers (àyàn) with god of drumming, Òrìsà Àyàn. As succinctly corroborated by Amanda Villepastour, “the ̣ drummer in action becomes Àyàn.” Another Yorùbá term for a drummer (àyàn) is onílù. 1 With their drumming (or drum music) that mimic the human speech, the Àyàn or Onílù verbalize words/speeches (òrọ̀ ) that is or are intelligible to the ears of their ̣ patrons, often the dance performers (oníjó). For that reason, ìlù, to the Yorùbá, is an instrument that acts as a speech surrogate (i.e., substitute). That the Yorùbá refer to ìlù as “the talking drum” underscores this assertion. In fact, they strongly believed that if handled by a skillful drummer (àyàn/onílù), ìlù, just like humans, can speak words or communicate effectively to those who understand the language of the drum. The Yorùbá phrase “a lifeless goat that speaks just like a human” (òkú-ewúré tíí fo ̣ ’hùn bí ènìyàn ̣ ), a euphemism for the goatskin fixed single- or double-headed hourglass drums that mimic human speech when drummed, is a testimony to ìlù as a true “talking drum.” Another Yorùbá saying that illustrates that ìlù is an instrument of language substitution is “that the gángan drum could speak in a human nasal tone of 1 Onílù is formed from two Yorùbá words oní and ìlù (literally, “owner of the drum” or “one who plays the drum”), a euphemism for the drummer. Thus, anybody that plays drum is an onílù. But those Yorùbá traditional professional onílù, like the dùndún and bàtá drummers, are specifically referred to as àyàn. Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún 3 voice is not without the help of the drummer’s own tip of the fingernails” (àti rán’mú gángan kò s’ẹ̀ yìn èékáná ̣ ). In Yorùbá traditional festivals, ritual performances, and religious practices in general, the role of àyàn whose drumming or drum music imitate and code the natural language (Yorùbá), cannot be overemphasized. The Yorùbá aphorism “without drum music, there is no way to celebrate” (láì sí’lù, taní jé ̣ s’eré òkúrùgbe!̣) is a testimony to the indispensable role of ìlù in the context of traditional Yorùbá visual and performance arts. A clear example is the Yorùbá art and ritual of Egúngún, the theme of this study. Paradoxically, many Yorùbá art scholars often make very little or no effort to explore the relevance of ìlù in their studies on Yorùbá visual culture, such as Egúngún. This has continued to make it become virtually impossible for a deeper understanding of Yorùbá art in particular and African art as a whole. Ironically, the same scholars prefer to invest their energy, searching outside of the art’s cultural origin to fulfil their primary goal of “appreciating” the African art, rather than searching within African culture, language and values, the very driving forces that gave rise to this art, and thus a catalyst to understanding it.2 It is on that note that I believe the question that scholars of African art should begin to ask themselves is: when will African art scholarship––unlike Western art studies that often demand intellectual rigor and professional thoroughness––rise above its present art “appreciating” status vis-à-vis African art? In my opinion, as this present study is aimed at confirming, the understanding of African art critically requires that scholars be fluent or at least confident in the reading, writing, and speaking of the language of the people whose art they study. Also heightening the problem of the lack of “understanding” of Yorùbá art is the very unique nature of it (as with other African art), in which an isolated work of art in context is a rarity. Thus, the present study examines the very indispensable roles of Àyàn drummers in the performance context of the annual Egúngún festival (odún Egúngún) in a Yorùbá community in Òkèigbó in Nigeria’s Ondo State. As a native speaker with access to Yorùbá philosophy, values and history, and who is fully aware of the fundamental importance of language in African art studies, I aim in this study to examine the mutual relationship existing between the Àyàn and Egúngún from the vantage point of the Yorùbá language, the medium through which the said Yorùbá philosophy, values and history are stored and expressed. It delves into the very root of Egúngún within the Yorùbá cultural context, where traditions and history are preserved and recorded not in the western-type of writing, but rather in the Yorùbá language, ritual performance and ceremonies. It is hoped that this study will facilitate a deeper understanding of Egúngún along with the 2 Personal communication with Professor Rowland Abíodún on April 2, 2017. 4 Oláwọlé Fámúlẹ̀ àyàn within the art and ritual performance context of the Odún Egúngún. The study illustrates the interconnection of the àyàn and Egúngún by first providing an overview of Yorùbá drums and their ritual contexts. This is followed by a close study of the Yorùbá ontological concept of Egúngún, one of the most valued patrons of Àyàn (the drummers), as an important form of Yorùbá religious beliefs and practices. Using the Egbé ̣ ̣ Òjẹ̀ ̣ (Cult of Egúngún) of the ancient Yorùbá town of Òkèigbó as a case study, the study concludes with an in-depth analysis of the role of Àyàn (Drummers) in Yorùbá art and ritual of Egúngún.
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Maslov, G. G., E. M. Yudina, and N. A. Rinas. "Increase in grain combine harvester performance and in quality of harvesting grain crops." IOP Conference Series: Earth and Environmental Science 949, no. 1 (January 1, 2022): 012109. http://dx.doi.org/10.1088/1755-1315/949/1/012109.

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Abstract Based on the analysis of the results of combine harvester production tests and the long-term studies, carried out by the authors, the directions for increase in combine harvester productivity and in grain crop harvesting quality, are proposed. In three blocks of directions for increasing the combine harvester efficiency, a new direction of completing multifunctional harvesting units, joining together grain harvesting with simultaneous performance of one of the accompanying operations (stubble plowing, straw pressing, sowing catch crops, etc.), is found. The acquisition of multifunctional harvesting units is based on self-propelled, all-wheel-drive harvesters, trailed and mounted on a power unit such as “Palesse” (Belarus). The original unit can be completed on the basis of a “Penha” pull-type combine (Brazil). Among other directions of combine efficiency increasing, the observance of the rhythm and flow of the working process is substantiated, the attention is paid to the complex performance of the harvesting period. Attention is also paid to the obligatory coordination of the relationship between combine parameters and harvesting conditions: field size, crop yield, combine nominal performance, working speed, header cutting width. The following is an example of the effective operation of a rotary combine harvester in comparison with a beater-drum one and its significant influence on the winter wheat grain quality of strong varieties. It has been proved that due to reducing the grain injury by the rotary threshing-separating unit, post-harvest ripening and cleaning on thrashing floor, it is possible to increase the grain quality indicators by one class.
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Zhang, Y., A. M. Partsalis, and S. M. Highstein. "Properties of superior vestibular nucleus flocculus target neurons in the squirrel monkey. II. Signal components revealed by reversible flocculus inactivation." Journal of Neurophysiology 73, no. 6 (June 1, 1995): 2279–92. http://dx.doi.org/10.1152/jn.1995.73.6.2279.

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1. Seven upward eye velocity flocculus target neurons (FTNs) and two flocculus projecting neurons (FPNs) were studied before and after ipsilateral flocculus inactivation by injection of muscimol in the alert squirrel monkey. An additional seven FTNs and seven FPNs recorded from the corresponding FTN and FPN areas were recorded after injection. Response properties of FTNs and FPNs were characterized by visual-vestibular interaction paradigms and were compared before and after flocculus inactivation. 2. In FTNs the mean firing rate increased within 2-5 min after muscimol injection in the flocculus and reached a plateau level in approximately 10-20 min. The average mean firing rate for seven FTNs increased from 117 to 174 spikes/s, a net increase of 57 spikes/s (49%). Accompanying the large increase of the mean firing rate, a spontaneous nystagmus in the darkness developed with the slow phase directed upward and contralateral. 3. The firing rate modulation during visual following of a sinusoidal optokinetic drum (0.5 Hz) decreased within 2-5 min after muscimol injection in the flocculus and reached a level of 0 in approximately 10-20 min for all FTNs. After that, some cells remained unmodulated for the period of recording; other cells gradually reversed their phase and developed a modulation out of phase with drum velocity. The depletion of the visual following eye velocity signal on superior vestibular nucleus (SVN) FTNs accompanied a small but consistent decrease of visual following eye velocity amplitude. The average maximum decrease of eye velocity was 26 +/- 9% (mean +/- SD). 4. After flocculus inactivation, even though the modulation response at 0.5 Hz during visual following was abolished, a slow-component eye velocity signal with the same on direction was revealed by a constant-velocity optokinetic stimulus. It is concluded that there are at least two kinds of eye velocity signals during the optokinetic response. These signals are combined at the FTNs and are subsequently relayed to the oculomotor neurons. The source of the fast component is the flocculus, and the source of the slow component is another, as yet unidentified brain structure. 5. The effect of flocculus inactivation on the modulation amplitude during the vestibuloocular reflex (VOR) in darkness was variable: two cells did not change, two cells decreased, and three cells increased their amplitude. The response phase tended to move toward a phase lead, but the change was small. The effect on VOR suppression was more prominent.(ABSTRACT TRUNCATED AT 400 WORDS)
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11

Gardner, Marie E. "Drug Therapy of Aggressive Behaviors Accompanying Dementia." Journal of Pharmacy Practice 8, no. 5 (October 1995): 194–207. http://dx.doi.org/10.1177/089719009500800503.

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Aggressive behaviors often accompany dementia in the elderly, institutionalized patient. These may include any number of verbal or physical acts, and range from swearing, threatening, to harming self, others, or property. Identifying specific target behaviors for treatment is important in selecting the appropriate therapeutic option. The major neurotransmitters involved in aggression include gamma-aminobutyric acid (GABA) and serotonin, which inhibit aggression, and dopamine, norepinephrine and acetylcholine, which increase it. Drug therapy for control of aggressive behaviors has traditionally included the antipsychotics and benzodiazepines. However, additional, newer therapies are also useful. Among these are the anticonvulsants carbamazepine and valproic acid, various beta-blocking agents, antidepressants, and buspirone. These medications may be needed when nondrug therapy for control of behavioral problems fails or is insufficient. Determining which behaviors are problematic and need treatment, knowing which medications are indicated for those problems, and noting contraindications for particular drug therapies will lead to the best therapeutic option for a given patient.
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Park, Namgi, Ja Young Jeon, Eugene Jeong, Soyeon Kim, and Dukyong Yoon. "Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus." Endocrinology and Metabolism 37, no. 1 (February 28, 2022): 65–73. http://dx.doi.org/10.3803/enm.2021.1275.

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Background: Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles. As it is often difficult to prove repositioning candidates’ effectiveness in real-world clinical settings, we used patient-centered real-world data for screening repositioning candidate drugs for multiple diseases simultaneously, especially for diabetic complications.Methods: Using the National Health Insurance Service-National Sample Cohort (2002 to 2013), we analyzed claims data of 43,048 patients with type 2 diabetes mellitus (age ≥40 years). To find repositioning candidate disease-drug pairs, a nested case-control study was used for 29 pairs of diabetic complications and the drugs that met our criteria. To validate this study design, we conducted an external validation for a selected candidate pair using electronic health records.Results: We found 24 repositioning candidate disease-drug pairs. In the external validation study for the candidate pair cerebral infarction and glycopyrrolate, we found that glycopyrrolate was associated with decreased risk of cerebral infarction (hazard ratio, 0.10; 95% confidence interval, 0.02 to 0.44).Conclusion: To reduce risks of diabetic complications, it would be possible to consider these candidate drugs instead of other drugs, given the same indications. Moreover, this methodology could be applied to diseases other than diabetes to discover their repositioning candidates, thereby offering a new approach to drug repositioning.
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Abbasi, Najmeh, and Alireza Baratloo. "Accompanying pseudoaneurysm and distant necrotizing fasciitis in an IV drug user." Visual Journal of Emergency Medicine 16 (July 2019): 100602. http://dx.doi.org/10.1016/j.visj.2019.100602.

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Chakinala, Raja Chandra, Shantanu Solanki, Khwaja F. Haq, Zahava C. Farkas, Lavneet Chawla, Charles J. Lugo, Dhruv Mehta, Jonathan E. Barsa, and Beth Schorr-Lesnick. "Esophagitis and Esophageal Ulceration Accompanying Drug-Induced Hypersensitivity Reaction to Phenytoin." American Journal of Gastroenterology 112 (October 2017): S894—S895. http://dx.doi.org/10.14309/00000434-201710001-01655.

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Frantsiyants, E. M., I. V. Kaplieva, V. A. Bandovkina, L. K. Trepitaki, E. I. Surikova, I. V. Neskubina, J. A. Pogorelova, et al. "Stellanin: a promising medical drug for accompanying therapy in lung cancer treatment." CARDIOMETRY, no. 20 (November 21, 2021): 35–40. http://dx.doi.org/10.18137/cardiometry.2021.20.3439.

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One of the cancer prevention measures involves the correctionof the altered functions of the body’s regulatory systems. Manymalignant tumors are accompanied by the thyroid system dysfunction.The aim of our study was to reveal an effect of an iodine-containingdrug on the development of a tumor process in thelungs and the level of thyroid hormones in blood and the thyroidgland in male rats.Material and methods. Outbred white male rats were dividedinto the following groups: a group of intact animals (n=7); acomparison group – 5 weeks after an intravenous inoculationof sarcoma 45 (S45) at 2*106 (n=7); a main group – 5 weeks afteran intravenous inoculation of S45 and intragastric administrationof Stellanin at a single dose of 0.4 mg/kg within an hourafter the inoculation (n=10). RIA was used to determine levels offree (F) and total triiodothyronine (T3) and thyroxine (T4) in theblood serum and the thyroid.Results. The lungs of rats in the comparison group were totallyaffected by the tumor, and the thyroid gland showed asharp decrease in the levels of all hormone forms: T4 – by 18.7times, T3 – by 8.5 times, FТ4 – by 8.1 times, FТ3 – by 21.3 times,while only FТ4 and FТ3 decreased in blood by 2.5 and 1.5 times,respectively (p<0.05). No tumor lesions were detected in thelungs of rats of the main group, and the hormone levels exceededthe levels in the comparison group: in the thyroid, FT4by 3.7, T4 by 15.0 and T3 by 6.0 times; in blood, FT4 by 3.3 andFT3 by 1.7 times.Conclusions. The effect of Stellanin inhibiting malignantgrowth of S45 in the lungs is accompanied by the restoration oflow levels of thyroid hormones in the thyroid and blood.
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OSHIMA, Mika, Kazutoshi MURAO, Takeshi ISHIGAMI, and Yoshiaki KUBO. "Drug eruption induced by gonadotropin-releasing hormone analogs accompanying radiation-recall phenomenon." Journal of Dermatology 39, no. 12 (May 9, 2012): 1080–81. http://dx.doi.org/10.1111/j.1346-8138.2012.01576.x.

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Simanjuntak, Bella Cindy Juwita, Pulumun Peterus Ginting, and Wiflihani Wiflihani. "Kolaborasi Alat Musik Tradisional dan Alat Musik Modern dalam Mengiringi Ibadah Minggu di HKBP Tanjung Sari Medan." Journal of Education, Humaniora and Social Sciences (JEHSS) 1, no. 3 (March 10, 2019): 170–76. http://dx.doi.org/10.34007/jehss.v1i3.35.

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This study discusses the collaboration of traditional musical instruments and modern musical instruments in accompanying Sunday services at HKBP Tanjung Sari Medan. The purpose of this study was to find out the background and process of collaboration of traditional musical instruments and modern musical instruments in the HKBP Tanjung Sari church in Medan. The method used in this study is qualitative descriptive. The location of the study was carried out at the Tanjung Sari HKBP church, Jl. Setia Budi No. 11, Medan. The population of this study is traditional musical instruments and modern musical instruments used in accompanying Sunday services at HKBP Tanjung Sari Medan. While the samples in this study were Taganing, drums, keyboards, acoustic guitars, bass guitars, saxophone which were used to accompany Sunday services at HKBP Tanjung Sari Medan. The data collection technique is through observation, interviews, documentation, and library studies. Based on the results of the study, it can be seen that traditional musical instruments and modern musical instruments used in accompanying Sunday services at HKBP Tanjung Sari Medan, namely: Taganing, drums, keyboards, acoustic guitars, bass guitars, saxophone. The songs used in accompanying Sunday Service at HKBP Tanjung Sari Medan, and the collaboration process of traditional musical instruments and modern musical instruments in the HKBP Tanjung Sari church in Medan.
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Kruglova, L. S., and N. S. Rudneva. "Role of dermatocosmetics and accompanying care in patients with psoriasis." Medical alphabet, no. 34 (December 17, 2021): 18–22. http://dx.doi.org/10.33667/2078-5631-2021-34-18-22.

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Dermatocosmetics plays an important role in psoriasis and is used in various dosage forms, depending on the localization of the process and with various active molecules that provide keratolytic, anti-inflammatory and moisturizing effects. Pierre Fabre company has developed the Kertyol P. S.O. (shampoo and concentrate for topical use), which provides additional skin care for psoriasis.Material and methods. 28 patients with psoriasis vulgaris with localization of the process on smooth skin and scalp were under observation. In all patients, the process corresponded to mild severity (PASI < 10 points). On smooth skin, patients used calcipotriol (one time per day) and Kertyol P. S.O. The drug was applied twice a day (morning and evening) to psoriatic plaques on the body for 4 weeks. Shampoo Kertyol P. S.O. was used 3 times a week for 4 weeks in conjunction with a local drug (hydrocortisone one time per day). Research results. Against the background of therapy with localization on smooth skin, after one week, there was a positive trend in relation to peeling, infiltration and erythema: the PASI index decreased by 13.0 %, in 4 weeks by 67.2 %. When localized on the scalp after a week, the PASI index decreased by 21.4 %, to the end of the observation period by 80.9 %. After 4 weeks of therapy, with localization on smooth skin, the VAS decreased by 77.2 % points, with localization on the scalp by 73.1 %. In general, for the group, DIKZH improved by 73.7 %. All the patients noted good organoleptic properties of dermatocosmetics, ease of use.Conclusion. Kertyol P. S.O. can be recommended as an adjuvant therapy for psoriasis of smooth skin and scalp.
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Navarro, P. Gutiérez, A. El Bekkouri, and E. Rodríguez Reinoso. "Fluorescence accompanying methanolysis of β-lactam antibiotics." Biomedical Chromatography 13, no. 2 (April 1999): 105–6. http://dx.doi.org/10.1002/(sici)1099-0801(199904)13:2<105::aid-bmc855>3.0.co;2-#.

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Tao, Zhimin, Syed S. Ahmad, Harvey S. Penefsky, Jerry Goodisman, and Abdul-Kader Souid. "Dactinomycin Impairs Cellular Respiration and Reduces Accompanying ATP Formation." Molecular Pharmaceutics 3, no. 6 (December 2006): 762–72. http://dx.doi.org/10.1021/mp0600485.

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Bandovkina, V. A., L. K. Trepitaki, E. I. Surikova, I. V. Neskubina, J. A. Pogorelova, N. D. Cheryarina, A. I. Shikhlyarova, et al. "Applicability of mitochondrial energy factors in accompanying therapy of lymphoproliferative diseases (experimental study)." CARDIOMETRY, no. 20 (November 21, 2021): 30–34. http://dx.doi.org/10.18137/cardiometry.2021.20.2933.

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Aim. The purpose of the study was to reveal the effectivenessof the Cytochrome C drug in the early stages of the Pliss lymphosarcomagrowth in white outbred rats.Material and methods. The studies were included white outbredmale rats with an initial weight of 180–220 g (n = 40) withsubcutaneously inoculated Pliss lymphosarcoma. Rats in themain group received the Cytochrome C intraperitoneally in asingle dose of 1.6 mg/kg 1 hour after the tumor inoculationand then until death; animals with tumors in the control groupreceived saline instead of the studied drug in the same way andin the same dosage.Results. Subcutaneous tumors appeared in the control groupin 100% cases, in the main group in 55% cases; tumors werenot detected in 45% of animals in the main group. In rats ofthe main group receiving experimental treatment, tumors regressedwith time: in 73% cases with complete recovery of rats,in 27% cases animals died.Conclusions. The Cytochrome C in a therapeutic and prophylacticregimen had a pronounced antitumor effect. Perhaps theeffectiveness of the drug can be improved using an inert carrierwhich will protect the protein from proteolytic cleavage whenit enters the bloodstream, together with detoxification agents.
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Soldatova, Galina E. "THE EXPERIENCE OF ANALYZING OF THE PITCH ORGANISATION OF MANSI ZITHER TUNES." Vestnik Tomskogo gosudarstvennogo universiteta. Kul'turologiya i iskusstvovedenie, no. 39 (2020): 214–25. http://dx.doi.org/10.17223/22220836/39/20.

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Mansi (Voguls) is one of the Ob-Ugric peoples of Western Siberia. Mansi have a lot of pho-noinstruments (including folk-music instruments): string (zither, lute, harp), shaman’s drum, hunter’s whistles, reindeer herder’s and household’s sounding items, children’s sound toys, etc. The most popu-lar of them is the zither named saŋkvəltap. This instrument is tuned over the diatonic pentachord: c-d-e-f-g or c-d-es-f-g, and there are other variants of tuning. When the traditional lifestyle still remained, the zither was played during rituals (such as a bear-feast, sacrifice ceremony, shamanic rite) and in other situations, accompanying dances and singing. Currently, the zither is played mainly by young musicians during the concerts. The purpose of the article is to describe the principles of the pitch organization of Mansi instru-mental music. The author had made recordings of playing of several old musicians, then the note tran-scription of that melodies has been made. The algorithm for the analysis is shown on the example of a single piece that is the personal melody of the deity in the image of a bear (“The Melody of the Clawed Old Man”). In the collection of analyzed tunes the following types of scales were found: 1) frequent: c-d-e-f-g, c-d-es-f-g, (c)-d-e-f-g, (c)-d-es-f-g; 2) rare: (c)-d-es-e-g, c-d-es-(f)-g, c-(d)-es-e-g. The tone functions can be such as a supporting tone, a semi-supporting tone, a non-supporting tone, an auxiliary tone. The tone functions are determined in each segment by the following signs: 1) accentuation; 2) location on the strong beat; 3) appearance on the boundaries of the composition units; 4) length of sounding; 5) multiple or frequent repetition. Semi-supporting tones are identified by the same criteria as the supporting ones, but they must have less ways of marking than the supporting tones. The auxiliary tones are rare, they don’t enter into the frame of melody and they are used only for variation. As a result of the analysis of the collection of tunes, the following patterns of the pitch-sound or-ganization of the instrumental music of Mansi are defined: 1) both of quarta and quinta modes are frequent; 2) the number of mode supporting tones is two or three, rarely – one or four, the semi-supporting tones are frequent; 3) the main supporting tones are at the highest and the lowest step of the scale. There is no strict correlation between the type of mode and the genre of the tune, but the following trend is noticeable. Melodies of deities and men’s dances in the modes of a quarta volume are performed more frequently. The epic or the song melodies and the melodies of women’s dances mainly sound in the modes of the quinta volume. On the basis of a comparison of several of the same name tunes (“Melody of the Old Man the Owl”), the following conclusion is drawn. The most important parameter of a pitch organization is the correlation of supporting tones and the sequence of appearance of typed intonational moves.
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Demirçin, Sema, Fatih Dirol, Yaşar Mustafa Karagöz, Aylin Aksoy, Derya Bulgur Kırbaş, and Pelin Göral. "Velvet Heart: Systemic Fungal Infection Accompanying With Cardiac Involvement and Review Of The Literature." Bulletin of Legal Medicine 22, no. 2 (August 4, 2017): 134–39. http://dx.doi.org/10.17986/blm.2017227926.

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Injuries and intoxications are frequent cause of deaths in illicit drug users. Drug abuse is also associated with increase in infectious diseases and decreased level of immunity. Especially collective usage of syringes can be remarkably dangerous. It is difficult to diagnose the fungal infections in people whose immune systems are deficient and spreading of the pathogenic microorganisms through the bloodstream can lead to systemic infections which can cause rapid death. In this article, a case of a 45-year-old man is being presented who died due to illicit drug intoxication. Apparent cardiac involvement with systemic fungal infection has been determined at the autopsy. The case has been evaluated with the literature. The skin and cardiac findings of the case are both rare and educational. Besides, this report aims to draw attention to systemic infectious diseases that can be found at autopsies of persons who had used illicit drugs and it is intended to review the measures for the protection of the autopsy personnel.
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Matyev, E. S., and A. P. Arzamastsev. "Study of accompanying impurities in methyltestqsterone by a combination of physicochemical methods." Pharmaceutical Chemistry Journal 19, no. 3 (March 1985): 212–15. http://dx.doi.org/10.1007/bf00770457.

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25

Murray, J. J., P. W. Reed, and J. G. Dobson. "Biochemical changes accompanying enhanced cardiac contractility by ionophore A23187." American Journal of Physiology-Heart and Circulatory Physiology 249, no. 6 (December 1, 1985): H1204—H1210. http://dx.doi.org/10.1152/ajpheart.1985.249.6.h1204.

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We have reported that the divalent cation ionophore A23187, like the beta-adrenergic agonist isoproterenol, increased the force of contraction and rate of relaxation and shortened the duration of contraction of papillary muscles isolated from guinea pigs. A23187 produced a fall in resting tension and decreased the contracture tension of K +/- depolarized muscles, as did isoproterenol. In the present studies, isoproterenol produced a concentration-dependent, rapid, and sustained increase in the cyclic AMP (cAMP) content of papillary muscle. In contrast, A23187 had no detectable effect on cAMP levels, even in the presence of the phosphodiesterase inhibitor, papaverine. Neither drug, at concentrations maximal for contractile effects, altered cyclic GMP (cGMP). Isoproterenol increased the cAMP-dependent protein kinase activity ratio, whereas A23187 did not change the activity of this enzyme. However, both A23187 and isoproterenol produced a concentration-dependent increase in phosphorylase activity. Concentrations of A23187 or isoproterenol that enhanced contractility maximally increased the alkali-labile phosphate (by ca. 35%) but were without effect on the acid-labile, alkali-stable phosphate in the total acid precipitable protein. Contractile effects of isoproterenol, which reflect activated Ca2+ uptake, and the increase in phosphorylase activity produced by this agent are believed to be due to an increase in cAMP with subsequent activation of cAMP-dependent protein kinases and phosphorylation of proteins. A23187 may produce similar contractile effects without an increase in cAMP or cAMP-dependent protein kinase activity by activating other protein kinases and/or inhibiting phosphoprotein phosphatases, most likely by its effects on intracellular calcium.
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Zhukova, Ye M., and V. A. Krasnov. "Basic program of treatment of pulmonary drug-resistant tuberculosis sufferers with accompanying bronchoobstructive syndrome." Bulletin of Siberian Medicine 11, no. 4 (August 28, 2012): 18–21. http://dx.doi.org/10.20538/1682-0363-2012-4-18-21.

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Zhukova, Ye M., and V. A. Krasnov. "Modern approaches to treatment of pulmonary drug-resistant tuberculosis sufferers with accompanying bronchoobstructive syndrome." Bulletin of Siberian Medicine 11, no. 6 (December 28, 2012): 204–6. http://dx.doi.org/10.20538/1682-0363-2012-6-204-206.

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ZALESKIS, GINTARAS, DAINIUS CHARACIEJUS, JURGITA JURSENAITE, LAVIJA ZIBUTYTE, KAROLINA KRIAUCIUNAITE, MILDA VANAGAITE-ZICKIENE, ADAS DARINSKAS, MANTAS JONUSIS, and VITA PASUKONIENE. "Thymus Subset Alterations Accompanying Concomitant Tumor Immunity Mimics Phenotypic Patterns of Cytotoxic Drug Doxorubicin." In Vivo 36, no. 3 (2022): 1106–13. http://dx.doi.org/10.21873/invivo.12808.

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IZUMO, KAZUHIDE. "Electrocardiogram findings and drug working situations accompanying disease groups of patients with atrial fibrillation." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 29, no. 1/2 (1998): 289–90. http://dx.doi.org/10.3999/jscpt.29.289.

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Sallier, Tatiana. "Semantic Shifts Displayed by Adjectives Accompanying Abstract Nouns." International Journal of English Language Teaching 9, no. 2 (August 9, 2022): 1. http://dx.doi.org/10.5430/ijelt.v9n2p1.

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The research is devoted to semantic changes undergone by adjectives accompanying abstract nouns in English and Russian. The article is aimed at proving that such adjectives lose their concrete lexical meaning and become intensifiers, that is undergo delexicalization. The nouns themselves serve as units of both lexical and syntactic context suppressing the elements of concrete meaning and enhancing the intensifying meaning. As a result of this process, synonymous relationship develops between adjectives which are not synonyms in other contexts. The process runs parallel in the two languages, with similar lexical sources, which makes it possible to assume that it is part of a general trend of semantic evolution from concrete to more abstract meanings.
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Mustikawati, Mustikawati, and Sodikin Sodikin. "Factors influencing the effectiveness of colonoscopy." Proceedings Series on Health & Medical Sciences 1 (December 10, 2020): 98–100. http://dx.doi.org/10.30595/pshms.v1i.43.

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Colonoscopy is one of the most widely-used procedures for diagnostic examination and treatment of colorectal diseases, either benign or malignant. Colonoscopy results are influenced by several factors such as current medical history, history of drug use, history of accompanying illnesses, and procedures performed. To analyze the factors which affectiverness the results of colonoscopy among the undergoing patients in Regional Public Hospital of Banyumas. The method used was observational analytic with a cross sectional approach. From the consecutive sample selection, it gave 76 respondents. The analysis was done using Univariate analysis with frequency distribution test, bivariate with chi square test and multivariate with multiple logistic regression test. Most of the respondents (51 respondents, 67.1%) aged 46-65 years and most of them were female (41 or 53.1%), they were dominated by high school graduates (56 or 73.7%), and the dominant occupation status was undemployed (31 or 40.8%). The results of the chi square test showed that there was an effect of current disease history, namely complaints / indications for colonoscopy examinations (p 0.011), drug use (p 0.021),accompanying disease history (p 0.003), and implementation procedures (p 0.000) on colonoscopy results. The results of multiple logistic regression showed that the factor that mostly influences the colonoscopy results was the length of preparation time (1-2 days of preparation).In conclusion current medical history, drug use history, accompanying medical history, and procedure administration significantly influence the colonoscopy outcome. And the most influencing factor is the length of preparation time (1-2 days of preparation).
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Felice, Carla, Daniela Pugliese, and Alessandro Armuzzi. "The role of healthcare providers in accompanying biosimilars in inflammatory bowel diseases." Expert Opinion on Biological Therapy 19, no. 10 (January 11, 2019): 967–69. http://dx.doi.org/10.1080/14712598.2019.1566455.

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33

Bewley-Taylor, David R., and Malgosia Fitzmaurice. "The Evolution and Modernisation of Treaty Regimes." International Community Law Review 20, no. 5 (October 10, 2018): 403–35. http://dx.doi.org/10.1163/18719732-12341383.

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Abstract The UN based framework for international drug control, described as the global drug prohibition regime, has displayed some capacity to evolve. This is the case both in terms of formal structures and accompanying norms. Recent moves by a small number of jurisdictions towards the legal regulation of cannabis for non-medical and non-scientific purposes has, however, highlighted the existence of systemic inertia in the face of unprecedented challenge. The resultant obstacles and accompanying recourse by states to creative legal argumentation contrasts with approaches found within the regime for environmental regulation and its underpinning Multilateral Environmental Agreements (MEAs). In this case a variety of structures and bodies characterise a more dynamic and responsive framework. It is argued here that while we should be alert to issue area specificity, much can be learned from MEAs and their regime evolution, in relation to governance structures and the use of Conferences of the Parties.
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34

Kahremany, Shirin, Lukas Hofmann, Arie Gruzman, and Guy Cohen. "Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch." International Journal of Molecular Sciences 21, no. 14 (July 10, 2020): 4883. http://dx.doi.org/10.3390/ijms21144883.

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Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation.
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Khandelia, Rumi, Satyapriya Bhandari, Uday Narayan Pan, Siddhartha Sankar Ghosh, and Arun Chattopadhyay. "Gold Nanocluster Embedded Albumin Nanoparticles for Two-Photon Imaging of Cancer Cells Accompanying Drug Delivery." Small 11, no. 33 (May 4, 2015): 4075–81. http://dx.doi.org/10.1002/smll.201500216.

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Khandelia, Rumi, Satyapriya Bhandari, Uday Narayan Pan, Siddhartha Sankar Ghosh, and Arun Chattopadhyay. "Drug Delivery: Gold Nanocluster Embedded Albumin Nanoparticles for Two-Photon Imaging of Cancer Cells Accompanying Drug Delivery (Small 33/2015)." Small 11, no. 33 (September 2015): 4074. http://dx.doi.org/10.1002/smll.201570201.

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Musiałowska, B., M. Rudzińska, E. Koc-Żórawska, and M. Żórawski. "Evaluation of renal function in primary care." Progress in Health Sciences 8, no. 2 (December 31, 2018): 202–5. http://dx.doi.org/10.5604/01.3001.0012.8347.

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Evaluation of renal function is one of the primary tools used in treatment and monitoring kidney injury such as acute kidney injury (AKI) or chronic kidney disease (CKD) in Primary Care patients. Accompanying chronic diseases also have an impact on the assessment of renal function, treatment monitoring and adjustment of drug doses.
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Spence, J. "Cyclobutene Formation Accompanying an Intramolecular Lewis Acid-Promoted Spirocyclization of a Propargylic Silane." Tetrahedron Letters 36, no. 31 (July 31, 1995): 5499–502. http://dx.doi.org/10.1016/00404-0399(50)1115x-.

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39

Di Marzo, Vincenzo. "Novel mechanisms in obesity, type 2 diabetes and accompanying inflammation: focus on lipid signaling." Drug Discovery Today: Disease Mechanisms 7, no. 3-4 (December 2010): e159-e161. http://dx.doi.org/10.1016/j.ddmec.2011.01.001.

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40

Saikia, Basanta, Andreas Seidel-Morgenstern, and Heike Lorenz. "Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide." Crystals 12, no. 1 (December 28, 2021): 40. http://dx.doi.org/10.3390/cryst12010040.

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Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD). The eutectic mixtures i.e., AMG-CAF (1:0.4, molar ratio), AMG-NIC (1:1.9, molar ratio) and AMG-ZMD (1:1.4, molar ratio) demonstrate significant melting point depressions ranging from 99.2 to 127.2 °C compared to the melting point of the drug AMG (151 °C) and also show moderately higher aqueous solubilities than that of the AMG. The results presented include the determination of the binary melt phase diagrams and accompanying analytical characterization via X-ray powder diffraction, FT-IR spectroscopy and scanning electron microscopy.
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Raaben, Matthijs, Guy C. M. Grinwis, Peter J. M. Rottier, and Cornelis A. M. de Haan. "The Proteasome Inhibitor Velcade Enhances rather than Reduces Disease in Mouse Hepatitis Coronavirus-Infected Mice." Journal of Virology 84, no. 15 (May 19, 2010): 7880–85. http://dx.doi.org/10.1128/jvi.00486-10.

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ABSTRACT Many viruses, including coronaviruses (CoVs), depend on a functional cellular proteasome for efficient infection in vitro. Hence, the proteasome inhibitor Velcade (bortezomib), a clinically approved anticancer drug, shown in an accompanying study (M. Raaben et al., J. Virol. 84:7869-7879, 2010) to strongly inhibit mouse hepatitis CoV (MHV) infection in cultured cells, seemed an attractive candidate for testing its antiviral properties in vivo. Surprisingly, however, the drug did not reduce replication of the virus in mice. Rather, inhibition of the proteasome caused enhanced infection with lethal outcome, calling for caution when using this type of drug during infection.
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42

Najm, Aseel S., and Wedad K. Ali. "Preparation and in-Vitro Evaluation of Cinnarizine Raft Forming Chewable Tablets." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 3 (August 1, 2019): 42–53. http://dx.doi.org/10.32947/ajps.v19i3.623.

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Cinnarizine is an anti-histaminic drug and is mainly used to treat symptoms accompanying motion sickness like vomiting and dizziness. It has low and variable bioavailability due to its low water solubility. Cinnarizine (weakly basic drug) is formulated as raft forming chewable Tablets to allow its complete dissolution at the stomach to be absorbed at the upper part of small intestine. Raft forming chewable Tablets are formulated by direct compression method using sodium alginate or pectin as raft forming agents. The prepared Tablets were evaluated for their pre and post- compression parameters and they have shown desirable results regarding evaluation of hardness, thickness, % friability, weight variation, content uniformity, raft strength, weight and volume, in addition to in-vitro drug release. Out of all the prepared formulas F1 selected as the optimum formula with 488.1mg raft strength and 92.34% drug release after 24hrs that is promising for the formulation of the raft system. Cinnarizine is an anti-histaminic drug and is mainly used to treat symptoms accompanying motion sickness like vomiting and dizziness. It has low and variable bioavailability due to its low water solubility. Cinnarizine (weakly basic drug) is formulated as raft forming chewable Tablets to allow its complete dissolution at the stomach to be absorbed at the upper part of small intestine. Raft forming chewable Tablets are formulated by direct compression method using sodium alginate or pectin as raft forming agents. The prepared Tablets were evaluated for their pre and post- compression parameters and they have shown desirable results regarding evaluation of hardness, thickness, % friability, weight variation, content uniformity, raft strength, weight and volume, in addition to in-vitro drug release. Out of all the prepared formulas F1 selected as the optimum formula with 488.1mg raft strength and 92.34% drug release after 24hrs that is promising for the formulation of the raft system.
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43

Zhao, Linling, Huarong Liu, Fengwei Wang, and Lai Zeng. "Design of yolk–shell Fe3O4@PMAA composite microspheres for adsorption of metal ions and pH-controlled drug delivery." J. Mater. Chem. A 2, no. 19 (2014): 7065–74. http://dx.doi.org/10.1039/c4ta00976b.

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Yolk–shell structured pH-responsive Fe3O4@PMAA microspheres have been prepared for adsorption of metal ions and drug delivery by combined sol–gel reaction, emulsion polymerization and selective etching methods accompanying hydrolysis of PMMA shells of core–shell–shell Fe3O4@SiO2@PMMA composite microspheres.
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44

Huang, Xin, Wendong You, Yuanrun Zhu, Kangli Xu, Xiaofeng Yang, and Liang Wen. "Microglia: A Potential Drug Target for Traumatic Axonal Injury." Neural Plasticity 2021 (May 20, 2021): 1–13. http://dx.doi.org/10.1155/2021/5554824.

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Traumatic axonal injury (TAI) is a major cause of death and disability among patients with severe traumatic brain injury (TBI); however, no effective therapies have been developed to treat this disorder. Neuroinflammation accompanying microglial activation after TBI is likely to be an important factor in TAI. In this review, we summarize the current research in this field, and recent studies suggest that microglial activation plays an important role in TAI development. We discuss several drugs and therapies that may aid TAI recovery by modulating the microglial phenotype following TBI. Based on the findings of recent studies, we conclude that the promotion of active microglia to the M2 phenotype is a potential drug target for the treatment of TAI.
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45

van Ameijden, E. J. C., J. A. R. van den Hoek, C. Hartgers, and R. A. Coutinho. "Risk Factors for the Transition from Noninjection to Injection Drug Use and Accompanying AIDS Risk Behavior in a Cohort of Drug Users." American Journal of Epidemiology 139, no. 12 (June 15, 1994): 1153–63. http://dx.doi.org/10.1093/oxfordjournals.aje.a116962.

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46

Mohasseb, Iman, and Christian A. Gericke. "Continuation of dual anti-platelet therapy after drug-eluting stents in primary angioplasty beyond 12 months." F1000Research 1 (November 21, 2012): 53. http://dx.doi.org/10.12688/f1000research.1-53.v1.

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In this correspondence we discuss the results of the meta-analysis by De Luca et al. (2012) in the Archives of Internal Medicine which found that late myocardial reinfarction and stent thrombosis is more common in drug-eluting stents than in bare-metal stents. We discuss the clinical implications of this paper for dual anti-platelet therapy which did not receive sufficient attention in the original publication and the accompanying editorial.
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47

Valiev, Timur T., Vera V. Semenova, Anna Yu Ikonnikova, Alisa A. Petrova, Tatiana S. Belysheva, and Tatiana V. Nasedkina. "Role of pharmacogenetic factors in the development of side effects of methotrexate in the treatment of malignant tumors: A review." Journal of Modern Oncology 23, no. 4 (December 15, 2021): 622–27. http://dx.doi.org/10.26442/18151434.2021.4.201127.

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Methotrexate (MTX) is one of the main chemotherapeutic agents that has determined the high effectiveness of protocols for the treatment of acute lymphoblastic leukemia and non-Hodgkin lymphomas. The reverse side of the high anti-tumor activity of MTX is the adverse reactions, which require accompanying preventive therapy. But even modern accompanying therapy in some cases does not avoid severe toxicity from the skin and mucous membranes, nervous system, kidneys, liver. MTX pharmacokinetics exhibits significant individual variability, which may be a reflection of genetic variability. Numerous pharmacogenetic studies have evaluated the effect of polymorphism of various genes involved in MTX metabolism on MTX pharmacokinetics and the development of toxic manifestations in order to improve patient outcomes and decrease drug toxicity. This review presents impact of key metabolic MTX genes (ATIC, DHFR, GGH, FPGS, MTHFR, MTR, MTRR, TYMS) and transporter proteins genes (ABCB1, ABCG2, ABCC2, ABCC4, SLC19A1, SLCO1B1) in the development of MTX side effects. Polymorphic markers in SLCO1B1 gene have the most influence with MTX pharmacokinetic.
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48

Kolesnik, K., Natal'ya Kaladze, and S. Severinova. "CLINICAL ASSESSMENT OF THE MAINTENANCE THERAPY EFFICACY IN THE ORTHODONTIC TREATMENT OF ADOLESCENTS WITH CHRONIC DISEASES OF THE UPPER PART GASTROINTESTINAL TRACT." Tavricheskiy Mediko-Biologicheskiy Vestnik 23, no. 3 (October 19, 2022): 39–44. http://dx.doi.org/10.29039/2070-8092-2020-23-3-39-44.

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The aim of the work is to provide a clinical assessment of the efficacy of therapy for accompanying orthodontic treatment of adolescents with chronic diseases of the upper part gastrointestinal tract. Material and methods. There were 109 adolescents at the age of 12–15 years with dental anomalies and gastroduodenal pathology (chronic gastritis, chronic gastroduodenitis, biliary dysfunction) were taken for orthodontic treatment. The state of oral hygiene, periodontal tissues and hard tooth tissues in the dynamics of orthodontic treatment was evaluated. We used the Silness-Loe and Stallard hygiene indexes, periodontal indexes – PMA, stomatorrhagia, Schiller-Pisarev, dental calculus, and calculated the reduction of caries. Results. Phased application of accompanying therapy (a calcium preparation with vitamin D3 and trace elements (Calcemin), magnesium (Magne B6), an immunostimulating drug of bacterial origin (Imudon) for the orthodontic treatment of adolescents with chronic pathology of the digestive tract shows an anti-inflammatory and caries static effect.
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49

DEWI, IDA AYU PUTU RATNA, NI LUH PUTU SUCIPTAWATI, and NI KETUT TARI TASTRAWATI. "APLIKASI REGRESI COX PROPORTIONAL HAZARD PADA SINTASAN PASIEN DIABETES MELITUS." E-Jurnal Matematika 7, no. 3 (September 2, 2018): 278. http://dx.doi.org/10.24843/mtk.2018.v07.i03.p215.

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Diabetes melitus is one of the deadliest diseases in the world. Until now, the incidence and the mortality rate due to diabetes melitus is still very high. To determine the survival of diabetes melitus patients, the significant factors that affect must be obtained by applying Cox Proportional Hazard regression method. The purpose of this study is to determine the chances of probability of diabetes melitus patients and to determine the significant factors that affect on the survival of diabetes melitus patients. The variables used in this study are the length of time of inpatient of diabetes melitus patient in RSUD Wangaya as dependent variable, while age, gender, genetic, blood glucose status, accompanying disease, pain, diabetes drug and insulin, and body mass index as independent variable. Through the analysis of this study we obtained the significant factors that affect the survival of diabetes melitus patients are sex, blood glucose status, and accompanying diseases.
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50

Wardman, Peter, Madeleine F. Dennis, Steven A. Everett, Kantilal B. Patel, Michael R. L. Stratford, and Michael Tracy. "Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs." Biochemical Society Symposia 61 (November 1, 1995): 171–94. http://dx.doi.org/10.1042/bss0610171.

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Drugs based on nitroarene, aromatic N-oxide or quinone structures are frequently reduced by cellular reductases to toxic products. Reduction often involves free radicals as intermediates which react rapidly with oxygen to form superoxide radicals, inhibiting drug reduction. The elevation of cellular oxidative stress accompanying oxygen inhibition of reduction is generally less damaging than drug reduction to toxic products, so the drugs offer selective toxicity to hypoxic cells. Since such cells are resistant to radiotherapy, these bioreductive drugs offer potential in tumour therapy. The basis for the selectivity of action entails kinetic competition involving the contesting reaction pathways. The reduction potential of the drug, radical pKa and nature of radical/radical decay kinetics all influence drug activity and selectivity, including the range of oxygen tensions over which the drug offers selective toxicity. These properties may be quantified using generation of radicals by pulse radiolysis, presenting a physicochemical basis for rational drug design.
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