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Journal articles on the topic 'Drugs administration'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Cavagna, Pauline, Simon Bizet, Fabienne Fieux, Emilie Houillez, Caroline Chirk, Chloé Zulian, Jennifer Perreux, Christine Fernandez, Thomas Lescot, and Marie Antignac. "Assessment of Good Practice Guidelines for Administration of Drugs via Feeding Tubes by a Clinical Pharmacist in the Intensive Care Unit." Critical Care Nurse 42, no. 6 (December 1, 2022): 54–65. http://dx.doi.org/10.4037/ccn2022395.

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Background In intensive care units, patients are frequently unable to take oral drugs because of orotracheal intubation or sedation. Local Problem Adverse events occurred during the administration of drugs by feeding tube. This study assessed the impact of implementing good practice guidelines by a clinical pharmacist on the prescription and administration of drugs through feeding tubes. Methods Nonconformity of drug prescription and administration in patients with feeding tubes was assessed before and after implementation of good practice guidelines in the intensive care unit of a large teaching hospital. Data were collected from medical records and interviews with physicians and nurses using a standardized form. Assessment of prescription nonconformity included compatibility of a drug’s absorption site with the administration route. Assessment of administration nonconformity included the preparation method. Results The analysis included 288 prescriptions and 80 administrations before implementation and 385 prescriptions and 211 administrations after implementation. Prescriptions in which the drug’s absorption site was not compatible with the administration route decreased significantly after implementation (19.8% vs 7.5%, P < .01). Administration nonconformity decreased significantly in regard to crushing tablets and opening capsules (51.2% vs 4.3%, P < .01) and the solvent used (67.1% vs 3.5%, P < .01). Simultaneous mixing of drugs in the same syringe did not decrease significantly (71.2% vs 62.9%, P = .17). Conclusion Implementation of good practice guidelines by a multidisciplinary team in the intensive care unit significantly improved practices for administering crushed, opened, and dissolved oral forms of drugs by feeding tube.

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2

Cook, Aaron M., Katherine D. Mieure, Robert D. Owen, Adam B. Pesaturo, and Jimmi Hatton. "Intracerebroventricular Administration of Drugs." Pharmacotherapy 29, no. 7 (July 2009): 832–45. http://dx.doi.org/10.1592/phco.29.7.832.

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3

SAKAKURA, Yasuo. "Nasal Administration of Drugs." Journal of the Society of Powder Technology, Japan 29, no. 5 (1992): 369–75. http://dx.doi.org/10.4164/sptj.29.369.

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4

Benedetti, F., E. Carlino, and A. Pollo. "Hidden Administration of Drugs." Clinical Pharmacology & Therapeutics 90, no. 5 (October 12, 2011): 651–61. http://dx.doi.org/10.1038/clpt.2011.206.

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5

Kiran, Shashi, and Teena Bansal. "Sublingual Administration of Drugs." Anesthesia & Analgesia 123, no. 1 (July 2016): 254. http://dx.doi.org/10.1213/ane.0000000000001346.

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6

Lebedev, I. A., E. V. Levitina, A. K. Akimzhanova, O. A. Rakhmanina, and T. E. Shtork. "Intrathecal administration of drugs." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 116, no. 10 (2016): 89. http://dx.doi.org/10.17116/jnevro201611610189-92.

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7

Scheibe, Mandy, Christopher Bethge, Martin Witt, and Thomas Hummel. "Intranasal Administration of Drugs." Archives of Otolaryngology–Head & Neck Surgery 134, no. 6 (June 1, 2008): 643. http://dx.doi.org/10.1001/archotol.134.6.643.

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8

Lopatka, P., M. Mastej, B. Krasinska, A. Niklas, and A. Tykarski. "MORNING VERSUS NIGHT DRUGS ADMINISTRATION." Journal of Hypertension 22, Suppl. 2 (June 2004): S96. http://dx.doi.org/10.1097/00004872-200406002-00332.

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9

Fludger, S., and T. Tarr. "Self-administration of drugs postoperatively." Anaesthesia 60, no. 10 (October 2005): 1047. http://dx.doi.org/10.1111/j.1365-2044.2005.04392.x.

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10

Hähnel, J., K. H. Lindner, and F. W. Ahnefeld. "Endobronchial administration of emergency drugs." Resuscitation 17, no. 3 (June 1989): 261–72. http://dx.doi.org/10.1016/0300-9572(89)90042-7.

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11

Wilkes, Gail. "Intravenous Administration of Antineoplastic Drugs." Journal of Infusion Nursing 32, no. 5 (September 2009): 276–85. http://dx.doi.org/10.1097/nan.0b013e3181b42ea1.

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12

Williams, Kate. "Administration of drugs are nurses breaking." Nursing Standard 11, no. 10 (November 27, 1996): 14–15. http://dx.doi.org/10.7748/ns.11.10.14.s30.

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13

O'Hare, M. C. B., A. M. Bradley, T. Gallagher, and M. D. Shields. "Errors in administration of intravenous drugs." BMJ 310, no. 6993 (June 10, 1995): 1536–37. http://dx.doi.org/10.1136/bmj.310.6993.1536c.

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14

&NA;. "72. ADMINISTRATION OF PARENTERAL INVESTIGATIONAL DRUGS." Journal of Infusion Nursing 29, Supplement (January 2006): S78. http://dx.doi.org/10.1097/00129804-200601001-00077.

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15

Ligumsky, M., M. Sestieri, F. Karmeli, J. Zimmerman, E. Okon, and D. Rachmilewitz. "Rectal Administration of Nonsteroidal Andinflammatory Drugs." Gastroenterology 98, no. 5 (May 1990): 1245–49. http://dx.doi.org/10.1016/0016-5085(90)90340-7.

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16

Duchěne, Dominique, and Gilles Ponchel. "Nasal Administration: A Tool for Tomorrow's Systemic Administration of Drugs." Drug Development and Industrial Pharmacy 19, no. 1-2 (January 1993): 101–22. http://dx.doi.org/10.3109/03639049309038763.

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17

Gettman, Lana. "New Drugs." Senior Care Pharmacist 36, no. 9 (September 1, 2021): 426–32. http://dx.doi.org/10.4140/tcp.n.2021.426.

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18

Souza, Sabrina de, Patrícia Kuerten Rocha, Patrícia Fernanda de Almeida Cabral, and Denise Miyuki Kusahara. "Use of safety strategies to identify children for drug administration." Acta Paulista de Enfermagem 27, no. 1 (February 2014): 06–11. http://dx.doi.org/10.1590/1982-0194201400003.

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OBJECTIVE: To understand the use of safety strategies in child identification for drug administration.METHODS: In this cross-sectional study at a pediatric unit, drugs were distributed in a centralized and unique manner. We conducted 373 observations of the process for preparing and distributing drugs carried out by 25 nursing professionals.RESULTS: The pharmacy had distributed 198 (53.1%) medicines without identifying the drugs' label, which, while in storage, was identified with the child's first name handwritten on adhesive tape. At the time of drug preparation, the professional transcribed the drug's name as described in the prescription to the drug label for 173 (90.6%) observations of injectable drug preparation and 161 (88.5%) observations of preparation of oral drugs. Information regarding the five rights of medication administration and preparation, such as the full name of the child, appeared on 10.7% of drug labels.CONCLUSION: No safety strategies to identify children during drug administration were found, nor were any standards for data identification observed.

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19

Elsayed, Eslam, Abdulla Al-Kamil, Emma Louise England, and Clifford L. Shelton. "Erroneous neuraxial administration of neuromuscular blocking drugs." European Journal of Anaesthesiology 38, no. 12 (December 2021): 1303–4. http://dx.doi.org/10.1097/eja.0000000000001460.

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20

Duffin, Christian. "Covert administration of drugs to be condemned." Nursing Standard 17, no. 34 (May 7, 2003): 9. http://dx.doi.org/10.7748/ns.17.34.9.s20.

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21

Weil, Max Harry, and Wanchun Tang. "Endotracheal administration of drugs during cardiopulmonary resuscitation." Critical Care Medicine 28, no. 6 (June 2000): 2144. http://dx.doi.org/10.1097/00003246-200006000-00087.

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22

OHTA, Michio, Sumiko MAJIMA, and Yoriyoshi KUMAGAI. "Optimal administration of anticoagulant drugs. 2nd Report." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 17, no. 2 (1986): 359–65. http://dx.doi.org/10.3999/jscpt.17.359.

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23

Czajkoski, Eugene H. "Drugs and the Warlike Administration of Justice." Journal of Drug Issues 20, no. 1 (January 1990): 125–29. http://dx.doi.org/10.1177/002204269002000108.

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24

Spencer, Samantha H., Shannon M. Menard, Malgorzata Z. Labedz, Courtney D. Krueger, and Katherine V. Sarna. "Enteral tube administration of oral chemotherapy drugs." Journal of Oncology Pharmacy Practice 26, no. 3 (January 19, 2020): 703–17. http://dx.doi.org/10.1177/1078155219893449.

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25

Birch, C., C. Hogan, and G. Mahoney. "Co-Administration of Drugs and Blood Products." Anaesthesia and Intensive Care 29, no. 2 (April 2001): 137–40. http://dx.doi.org/10.1177/0310057x0102900207.

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26

Küpper, Thomas E. A. H., Bettina Schraut, Burkhard Rieke, Arnica‐Verena Hemmerling, Volker Schöffl, and Juergen Steffgen. "Drugs and Drug Administration in Extreme Environments." Journal of Travel Medicine 13, no. 1 (January 1, 2006): 35–47. http://dx.doi.org/10.1111/j.1708-8305.2006.00007.x.

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27

Hutcheon, Duncan E. "Drugs Approved by Food & Drug Administration." Journal of Clinical Pharmacology 29, no. 5 (May 1989): 478–79. http://dx.doi.org/10.1002/j.1552-4604.1989.tb03366.x.

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28

Graves, Nina M., and Robert L. Kriel. "Rectal administration of antiepileptic drugs in children." Pediatric Neurology 3, no. 6 (November 1987): 321–26. http://dx.doi.org/10.1016/0887-8994(87)90001-4.

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29

Salo, Sergii V., Valentyn O. Shumakov, Andrii Yu Gavrylyshyn, Olena V. Levchyshyna, and Sergii S. Shpak. "Intracoronary Administration of Drugs in Clinical Practice." Ukrainian Journal of Cardiovascular Surgery 30, no. 4 (December 26, 2022): 12–19. http://dx.doi.org/10.30702/ujcvs/22.30(04)/ss051-1219.

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Intracoronary administration of drugs allows to achieve the fastest possible effect in interventional cardiology. This allows to avoid all the biological filters of the body and achieve the required concentration of the active substance at the injection site. Also, given the local action, systemic side effects are nearly absent. The aim. To study the literature data of the leading countries of the world in the field of intracoronary drug administration. To analyze the experience of different centers on the use of various medications in the treatment of the phenomenon of distal microembolization. Results. One of the first drugs administered intracoronary was streptokinase for the treatment of acute myocardial infarction. After that, it became clear that this method of delivering drugs is possible and can be used. With the beginning of the treatment of acute coronary syndromes by stenting, one of the possible complications arose in the form of no-reflow. At the same time, realizing that this is a local problem, they began to use the possibility of intracoronary administration of drugs to treat this phenomenon. The main advantage of this method is quick response to drug administration. Today, the drugs of choice in the treatment of no-reflow are verapamil, adenosine, nitroprusside, adrenaline. On the other hand, probably the most common drug that is administered intracoronary is nitroglycerin. It is used as a vasodilator in the event of spasm of the coronary arteries. Subsequently, it has been recommended to deliver drugs via a microcatheter or aspiration catheter to achieve even more selective effect in the area of the affected vessel, and this also minimizes drug loss due to coronary reflux into the aortic sinuses while usinga guiding catheter. Work is also underway on the use of intracoronary insulin in acute coronary syndrome in order to reduce the area of damage in myocardial infarction. It is also very promising to study the introduction of stem cells directlyinto the myocardium through a microcatheter in order to regenerate the myocardium after a heart attack. Conclusions. Intracoronary administration of drugs allows to achieve the maximum effect in the shortest possible time. Today, many drugs can be used in this way, starting from the treatment of the phenomenon of distal microembolization and ending with myocardial regeneration after myocardial infarction.

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30

Kasimov, Elmar Mustafa Ogly. "Electrophysiological Study of Campbell Line Rats Before and After the Administration of Drugs." International Journal of Psychosocial Rehabilitation 24, no. 5 (April 20, 2020): 4680–88. http://dx.doi.org/10.37200/ijpr/v24i5/pr2020181.

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31

Sampson, Michael. "Antiarrhythmic drugs part 2: rhythm-control drugs." British Journal of Cardiac Nursing 14, no. 10 (October 1, 2019): 1–11. http://dx.doi.org/10.12968/bjca.2019.0067.

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Rhythm-control drugs are used to terminate arrhythmias, and/or prevent their recurrence. They are a heterogeneous group of medicines with a wide range of indications, mechanisms and pharmacological properties. In this second article of a three-part series, three commonly used rhythm-control drugs are evaluated: adenosine, amiodarone and flecainide. In addition to describing each drug and its uses, important practice points are identified with the aim of promoting safe prescribing and administration.

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32

Nishihara, K., T. Shimizu, H. Kotaki, Y. Sawada, T. Okuno, K. Kaga, T. Murofushi, and T. Iga. "Lack of effect of vancomycin and gentamicin on auditory function in guinea pigs." Antimicrobial Agents and Chemotherapy 40, no. 5 (May 1996): 1098–103. http://dx.doi.org/10.1128/aac.40.5.1098.

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The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (22 days) intramuscular administrations of VCM (200 mg/kg of body weight) alone and GM (50 mg/kg) alone were not significantly different from those after combined administration of VCM (200 mg/kg) and GM (50 mg/kg). There was no change in the penetration ratio of VCM and GM into perilymph between administration of VCM or GM alone and the combination of both drugs. Furthermore, the hearing threshold of guinea pigs was not affected by VCM or GM alone or the combination of both drugs within the range of therapeutic VCM and GM levels in plasma in humans.

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33

Miyagi, Y., K. Fujiwara, S. Nagao, J. Kigawa, K. Miyake, T. Oda, and Y. Miyagi. "Computer simulation of pharmacokinetic analysis of 161,051 drugs after intraperitoneal (IP) or intravenous (IV) administrations." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 16042. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16042.

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16042 Background: Recent clinical studies for ovarian cancer have demonstrated the survival benefit of intraperitoneal (IP) administration of anti-cancer drugs, such as platinum agents, or paclitaxel. It is of great interest to investigate whether IP administration of other cytotoxic agents are more effective compared with intravenous (IV) administration. In this study we investigated the pharmacological advantage of IP administration using anti-cancer drugs, of which cytocidal effect is determined by the value of the area under the time concentration curve (AUC), by using computer simulation model. Methods: The 3-compartment pharmacokinetic computer model was used and 161,051 sets of the rate constants were substituted into the model. Because one set of the rate constants determines a pharmacokinetic behavior of one drug, it was considered to simulate over 160,000 drugs in this study. The constants were referred to ones of carboplatin. The simulations were made after 210 mg/body of the drugs were administered. The values of the AUC in the serum and in the IP cavity after IP or IV administration were calculated for each set, and then, these two administration methods were compared. Results: The values of the AUC in the serum by IP vs IV administration were 6.675 ± 21.603 (mean±SD); [0.08 - 106.155 (range)] vs 6.663 ± 21.541; [0.183 - 105.726]. The values of the AUC in the cavity after IP vs IV administration were 128.799 ± 344.491; [0.342 - 2288.48] vs 90.700 ± 283.946; [0.002 - 2259.32]. The ratios of AUC in the serum after IP or IV administrations were 0.995 ± 0.023; [0.401 - 1.020]. 147,201 sets (91.4%) were between 0.99 and 1.01. On the other hand, the ratios in the IP cavity were 25.327 ± 86.515; [1.003 - 548.976]. All the IP/IV ratios in the cavity were more than 1. Conclusions: The simulated probability clearly indicated that IP administration is not a local but a systemic chemotherapy for most drugs. All of the chemotherapeutic agents should be investigated for IP administration as well as conventional IV administration in clinical research protocol, especially in phase I/II study to clarify the effects and toxicities. No significant financial relationships to disclose.

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34

Salamah, Ardhanarishwari Umi, Fita Rahmawati, and Fivy Kurniawati. "Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital." JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) 9, no. 4 (December 31, 2019): 238. http://dx.doi.org/10.22146/jmpf.40930.

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Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials.

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35

Prasad, G., K. Devika, P. Varshith, B. Shravani, E. Pavithra, and Ch Swathi. "Design and Optimizations of Aceclofenac Bioadhesive Extended Release Microspheres." Pharmaceutics and Pharmacology Research 4, no. 4 (December 3, 2021): 01–15. http://dx.doi.org/10.31579/2693-7247/055.

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The oral route for drug delivery is the most popular, desirable, and most preferred method for administrating therapeutically agents for systemic effects because it is a natural, convenient, and cost effective to manufacturing process. Oral route is the most commonly used route for drug administration. Although different route of administration are used for the delivery of drugs, oral route remain the preferred mode. Even for sustained release systems the oral route of administration has been investigated the most because of flexibility in designing dosage forms. Present controlled release drug delivery systems are for a maximum of 12 hours clinical effectiveness. Such systems are primarily used for the drugs with short elimination half life.

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36

O??Dwyer, Peter J., James P. Stevenson, and Steven W. Johnson. "Clinical Pharmacokinetics and Administration of Established Platinum Drugs." Drugs 59, Supplement 4 (2000): 19–27. http://dx.doi.org/10.2165/00003495-200059004-00003.

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37

Xiong, Liu‐Lin, Hong‐Su Zhou, Ting‐Ting Li, Qiu‐Xia Xiao, and Zhao‐Qiong Zhu. "Hypoxic‐ischemic brain injury and narcotic drugs administration." Ibrain 6, no. 2 (January 2020): 18–23. http://dx.doi.org/10.1002/j.2769-2795.2020.tb00048.x.

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38

Moody, G. A., J. A. Eaden, Z. Helves, and J. F. Mayberry. "Oral or rectal administration of drugs in IBD?" Alimentary Pharmacology & Therapeutics 11, no. 5 (October 1997): 999–1000. http://dx.doi.org/10.1111/j.1365-2036.1997.tb00001.x.

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39

Kesselheim, Aaron S., Thomas J. Hwang, and Jerry Avorn. "Paying for Prescription Drugs in the New Administration." JAMA 325, no. 9 (March 2, 2021): 819. http://dx.doi.org/10.1001/jama.2021.0009.

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40

Schargus, Marc, and Andreas Frings. "Issues with Intravitreal Administration of Anti-VEGF Drugs." Clinical Ophthalmology Volume 14 (March 2020): 897–904. http://dx.doi.org/10.2147/opth.s207978.

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41

Talibov, Talibov O. B. "Clinical pharmacology of drugs in their intravaginal administration." Akusherstvo i ginekologiia 12_2020 (December 21, 2020): 194–98. http://dx.doi.org/10.18565/aig.2020.12.194-198.

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42

Kim, Jin Woo, Mi Young Cho, Bo-Young Jee, Myoung Ae Park, and Na Young Kim. "Administration and use of aquaculture drugs in Korea." Journal of fish pathology 27, no. 1 (April 30, 2014): 67–75. http://dx.doi.org/10.7847/jfp.2014.27.1.067.

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43

Peett, Alison, and Karen Cox. "Self-administration of drugs on an oncology ward." British Journal of Nursing 5, no. 5 (March 14, 1996): 283–86. http://dx.doi.org/10.12968/bjon.1996.5.5.283.

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44

Lomaestro, Ben M., and Timothy S. Lesar. "Concurrent administration of ciprofloxacin and potentially interacting drugs." American Journal of Health-System Pharmacy 46, no. 9 (September 1, 1989): 1770. http://dx.doi.org/10.1093/ajhp/46.9.1770.

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Furlan, Anthony J., and Marc Fisher. "Devices, Drugs, and the Food and Drug Administration." Stroke 36, no. 2 (February 2005): 398–99. http://dx.doi.org/10.1161/01.str.0000153057.07181.94.

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Baptista, T., A. Lacruz, D. De Mendoza, J. M. Mendoza, R. Silvera, F. Angeles, M. T. Mendoza, and L. Hernandez. "Body Weight Gain after Administration of Antipsychotic Drugs." Pharmacopsychiatry 35, no. 1 (January 2002): 36. http://dx.doi.org/10.1055/s-2002-19839.

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47

Hawkins, Patti R. "Medication Administration Records for Drugs Given During Surgery." American Journal of Health-System Pharmacy 50, no. 12 (December 1, 1993): 2558–59. http://dx.doi.org/10.1093/ajhp/50.12.2558.

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48

Rowbotham, Michael C. "PAINʼs policy on the spinal administration of drugs." Pain 149, no. 3 (June 2010): 415–16. http://dx.doi.org/10.1016/j.pain.2010.02.027.

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49

Moutardier, V. "Colloidal anticancer drugs bioavailabilities in oral administration models." International Journal of Pharmaceutics 260, no. 1 (July 9, 2003): 23–38. http://dx.doi.org/10.1016/s0378-5173(03)00231-x.

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50

Couvreur, Patrick. "Targeting of drugs and innovations in drug administration." Biology of the Cell 91, no. 3 (June 1999): 244–45. http://dx.doi.org/10.1016/s0248-4900(99)90091-6.

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