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Relevant bibliographies by topics / Drugs administration

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Academic literature on the topic 'Drugs administration'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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Journal articles on the topic "Drugs administration"

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Cavagna, Pauline, Simon Bizet, Fabienne Fieux, Emilie Houillez, Caroline Chirk, Chloé Zulian, Jennifer Perreux, Christine Fernandez, Thomas Lescot, and Marie Antignac. "Assessment of Good Practice Guidelines for Administration of Drugs via Feeding Tubes by a Clinical Pharmacist in the Intensive Care Unit." Critical Care Nurse 42, no. 6 (December 1, 2022): 54–65. http://dx.doi.org/10.4037/ccn2022395.

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Background In intensive care units, patients are frequently unable to take oral drugs because of orotracheal intubation or sedation. Local Problem Adverse events occurred during the administration of drugs by feeding tube. This study assessed the impact of implementing good practice guidelines by a clinical pharmacist on the prescription and administration of drugs through feeding tubes. Methods Nonconformity of drug prescription and administration in patients with feeding tubes was assessed before and after implementation of good practice guidelines in the intensive care unit of a large teaching hospital. Data were collected from medical records and interviews with physicians and nurses using a standardized form. Assessment of prescription nonconformity included compatibility of a drug’s absorption site with the administration route. Assessment of administration nonconformity included the preparation method. Results The analysis included 288 prescriptions and 80 administrations before implementation and 385 prescriptions and 211 administrations after implementation. Prescriptions in which the drug’s absorption site was not compatible with the administration route decreased significantly after implementation (19.8% vs 7.5%, P < .01). Administration nonconformity decreased significantly in regard to crushing tablets and opening capsules (51.2% vs 4.3%, P < .01) and the solvent used (67.1% vs 3.5%, P < .01). Simultaneous mixing of drugs in the same syringe did not decrease significantly (71.2% vs 62.9%, P = .17). Conclusion Implementation of good practice guidelines by a multidisciplinary team in the intensive care unit significantly improved practices for administering crushed, opened, and dissolved oral forms of drugs by feeding tube.

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Cook, Aaron M., Katherine D. Mieure, Robert D. Owen, Adam B. Pesaturo, and Jimmi Hatton. "Intracerebroventricular Administration of Drugs." Pharmacotherapy 29, no. 7 (July 2009): 832–45. http://dx.doi.org/10.1592/phco.29.7.832.

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SAKAKURA, Yasuo. "Nasal Administration of Drugs." Journal of the Society of Powder Technology, Japan 29, no. 5 (1992): 369–75. http://dx.doi.org/10.4164/sptj.29.369.

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Benedetti, F., E. Carlino, and A. Pollo. "Hidden Administration of Drugs." Clinical Pharmacology & Therapeutics 90, no. 5 (October 12, 2011): 651–61. http://dx.doi.org/10.1038/clpt.2011.206.

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Kiran, Shashi, and Teena Bansal. "Sublingual Administration of Drugs." Anesthesia & Analgesia 123, no. 1 (July 2016): 254. http://dx.doi.org/10.1213/ane.0000000000001346.

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Lebedev, I. A., E. V. Levitina, A. K. Akimzhanova, O. A. Rakhmanina, and T. E. Shtork. "Intrathecal administration of drugs." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 116, no. 10 (2016): 89. http://dx.doi.org/10.17116/jnevro201611610189-92.

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Scheibe, Mandy, Christopher Bethge, Martin Witt, and Thomas Hummel. "Intranasal Administration of Drugs." Archives of Otolaryngology–Head & Neck Surgery 134, no. 6 (June 1, 2008): 643. http://dx.doi.org/10.1001/archotol.134.6.643.

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Lopatka, P., M. Mastej, B. Krasinska, A. Niklas, and A. Tykarski. "MORNING VERSUS NIGHT DRUGS ADMINISTRATION." Journal of Hypertension 22, Suppl. 2 (June 2004): S96. http://dx.doi.org/10.1097/00004872-200406002-00332.

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Fludger, S., and T. Tarr. "Self-administration of drugs postoperatively." Anaesthesia 60, no. 10 (October 2005): 1047. http://dx.doi.org/10.1111/j.1365-2044.2005.04392.x.

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Hähnel, J., K. H. Lindner, and F. W. Ahnefeld. "Endobronchial administration of emergency drugs." Resuscitation 17, no. 3 (June 1989): 261–72. http://dx.doi.org/10.1016/0300-9572(89)90042-7.

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Dissertations / Theses on the topic "Drugs administration"

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Weise-Kelly, Lorraine Ann. "Drug-induced ataxia : effect of the self-administration contingency /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0030/NQ66245.pdf.

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Cai, Bing. "Ceramic Materials for Administration of Potent Drugs." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245031.

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This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions. Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. The synthesis conditions and excipients composition of the geopolymer-based formulation were modified in this work to facilitate a stable and extended drug delivery. Results showed that 37ºC 100% humidity for 48 hours were applicable conditions to obtain geopolymer with suitable mechanical strength and porosity. Moreover, it was found that the integration of poly(methyl acrylate) into the geopolymer-based formulation could reduce the drug release at low pH and, meanwhile, maintain the mechanical strength. Therefore, the geopolymer-based drug formulations concluded from these studies were applied in oral and transdermal delivery systems. Evidence of the tamper-resistance of geopolymer-based oral and transdermal formulations was documented and compared to the corresponding commercial opioid formulations. The results provided experimental support for the positive effects of geopolymers as drug carriers for the tamper-resistance of oral and transdermal delivery systems. Self-setting bioceramics, calcium phosphate and calcium sulfate were fabricated into transdermal enhancement protrusions in this work for the first time. Results showed that, under mild conditions, both bioceramics could form pyramid-shaped needles in the micron size. The drug release from these needles could be controlled by the bulk surface area, porosity and degradation of the bioceramics. An in vitro insertion test showed that the bioceramic microneedles had enough mechanical strength to insert into skin. Further optimization on the geometry of needles and the substrate material was also performed. The higher aspect-ratio needles with a flexible and self-swellable substrate could release most of the drug content within 4 hours and could penetrate through the stratum corneum by manual insertion. This study explored the potential application of bioceramics in transdermal enhancement protrusions and showed promising indication of their future developments.

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Copping, N. M. "Studies on the rectal administration of drugs." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372664.

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Espefält, Westin Ulrika. "Olfactory Transfer of Analgesic Drugs After Nasal Administration." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7829.

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Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. Evidence for the olfactory transfer of drugs from the nasal cavity to the CNS after nasal administration, bypassing the BBB, is available for both animals and humans. The aims of this thesis were to study the olfactory transfer of morphine to the CNS after nasal administration, and to compare the nasal transport of analgesic drugs across nasal respiratory and olfactory mucosa. In vivo studies in rodents demonstrated that morphine is transferred via olfactory pathways to the olfactory bulbs and the longitudinal fissure of the brain after nasal administration. Further, olfactory transfer of morphine significantly contributed to the early high morphine brain hemisphere concentrations seen after nasal administration to rats. Olfactory transfer was tracked by collecting and analysing brain tissue and blood samples after right-sided nasal administration and comparing the results to the situation after i.v. administration. The olfactory transfer was also visualised by brain autoradiography. In vitro studies indicated that the olfactory mucosa should not be a major barrier to the olfactory transfer of dihydroergotamine or morphine, since transport of these drugs was no more restricted across the olfactory mucosa than across the nasal respiratory mucosa. The in vitro studies were performed using the horizontal Ussing chamber method. This method was further developed to enable comparison of drug transport across nasal respiratory and olfactory mucosa which cannot be achieved in vivo. In conclusion, these analgesic drugs showed potential for olfactory transfer, and access to the CNS by this route should be further investigated in humans, especially for the drugs with central effects that are currently under development for nasal administration.

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Espefält, Westin Ulrika. "Olfactory transfer of analgesic drugs after nasal administration /." Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7829.

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Lukashevych, I. V. "Efficacy of some herbal drugs administration for patients with urolithiasis." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17098.

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Popova, M. "The risk of avitaminosis due to administration of antivitamin drugs." Thesis, Київський національний університет технологій та дизайну, 2019. https://er.knutd.edu.ua/handle/123456789/14395.

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Mauludin, Rachmat [Verfasser]. "Nanosuspensions of poorly soluble drugs for oral administration / Rachmat Mauludin." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/102346568X/34.

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Hu, Leijun. "Suramin pharmacokinetics after regional or systemic administration." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114449390.

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Falcone, Pin Bruno Nicolás. "Physicochemical properties of inhalation drugs." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648175.

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Books on the topic "Drugs administration"

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Ottenbrite, Raphael M., ed. Polymeric Drugs and Drug Administration. Washington, DC: American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0545.

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Drug Enforcement Administration. New York: Chelsea House Publishers, 2011.

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Deter, Lena L. Medication administration. Clifton Park, NY: Delmar/Cengage Learning, 2011.

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Wiley, Katherine L. Pocket drugs & classifications. Philadelphia, PA: F.A. Davis, 2012.

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Drugs and prison. New York: Rosen Pub. Group, 1995.

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Adint, Victor. Drugs and prison. New York: Rosen Pub. Group, 1995.

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Council, Nursing and Midwifery. Guidelines for the administration of medicines. London: Nursing & Midwifery Council, 2004.

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Pocket drugs & classifications. Philadelphia, PA: F.A. Davis, 2012.

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F, Kydonieus Agis, and Berner Bret, eds. Transdermal delivery of drugs. Boca Raton, Fla: CRC Press, 1987.

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Advanced medication administration skills. Clifton Park, NY: Thomson Delmar Learning, 2007.

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Book chapters on the topic "Drugs administration"

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Carson, David, Jonathan Montgomery, and Elsa Montgomery. "The administration of drugs." In Nursing and the Law, 64–70. London: Macmillan Education UK, 1989. http://dx.doi.org/10.1007/978-1-349-10961-6_7.

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Morgan, Michael M., MacDonald J. Christie, Luis De Lecea, Jason C. G. Halford, Josee E. Leysen, Warren H. Meck, Catalin V. Buhusi, et al. "Self-Administration of Drugs." In Encyclopedia of Psychopharmacology, 1197–202. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_353.

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Roberts, David C. S. "Self-Administration of Drugs." In Encyclopedia of Psychopharmacology, 1536–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_353.

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Roberts, David C. S. "Self-Administration of Drugs." In Encyclopedia of Psychopharmacology, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27772-6_353-2.

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Greenshaw, Andrew J., Glen B. Baker, and Thomas B. Wishart. "Dopamine Receptor Changes During Chronic Drug Administration." In Psychoactive Drugs, 353–406. Totowa, NJ: Humana Press, 1989. http://dx.doi.org/10.1007/978-1-59259-464-1_7.

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Meisch, Richard A., and Marilyn E. Carroll. "Oral Drug Self-Administration: Drugs as Reinforcers." In Methods of Assessing the Reinforcing Properties of Abused Drugs, 143–60. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4612-4812-5_7.

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Granero, Luis, and Ana Polache. "Absorption of Drugs after Oral Administration." In Preclinical Development Handbook, 281–321. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470249031.ch9.

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Fleischer, Julia. "Federal Administration." In Public Administration in Germany, 61–79. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-53697-8_5.

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AbstractThe federal administration is significantly small (around 10 percent of all public employees). This speciality of the German administrative system is based on the division of responsibilities: the central (federal) level drafts and adopts most of the laws and public programmes, and the state level (together with the municipal level) implements them. The administration of the federal level comprises the ministries, subordinated agencies for special and selected operational tasks (e.g. the authorisation of drugs, information security and registration of refugees) in distinct administrative sectors (e.g. foreign service, armed forces and federal police). The capacity for preparing and monitoring government bills and statutory instruments is well developed. Moreover, the instruments and tools of coordination are exemplary compared with other countries, although the recent digital turn has been adopted less advanced than elsewhere.

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Saffran, Murray. "Oral Administration of Insulin: Imitating the Natural Pathway." In Targeting of Drugs 3, 89–95. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-2938-5_10.

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Saffran, Murray. "Oral Administration of Peptides: Bypassing a Hostile Milieu." In Targeting of Drugs 3, 81–87. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-2938-5_9.

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Conference papers on the topic "Drugs administration"

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Rautiola, Davin, and Ronald A. Siegel. "Nasal Spray Device for Administration of Two-Part Drug Formulations." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3216.

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Intranasal drug delivery is an attractive route to noninvasively achieve a rapid therapeutic effect, avoid first pass metabolism, and bypass the blood brain barrier. However, the types of drugs that can be administered by this route has been limited, in part, by device technology. Herein, we describe a pneumatic nasal spray device that is capable of mixing liquid and solid components of a drug formulation as part of the actuation process during dose administration. The ability to store a nasal spray drug formulation as two separate components can be leveraged to solve a variety of stability issues that would otherwise preclude intranasal administration. Examples of drugs that could be delivered intranasally by utilizing this two-part formulation strategy include biomolecules that are unstable in solution and low solubility drugs that can be rendered into metastable supersaturated solutions. A proof of concept nasal spray device prototype was constructed to demonstrate that a liquid and solid can be rapidly mixed and atomized into a spray in a single action. The primary breakup distance and angle of the spray cone were measured as a function of the function of the propellant gas pressure.

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Brash, Jimmy, Alison Bacon, George Coxon, Julie Cuckson, Andrew Fletcher, Tracy Parkinson, Debbie Seed, Barbara Sutton, and Jayne Wilkinson. "P-127 Improving administration time of controlled drugs." In Leading, Learning and Innovating, Hospice UK 2017 National Conference, 22–24 November 2017, Liverpool. British Medical Journal Publishing Group, 2017. http://dx.doi.org/10.1136/bmjspcare-2017-hospice.152.

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Thurgood, Martin, Marie-Claire Rooney, Rachel Nakaanga, Margaret Wilcock, and Sara Skandarajah. "P-61 Reinventing nurse administration of controlled drugs." In Accepted Oral and Poster Abstract Submissions, The Palliative Care Congress, Recovering, Rebounding, Reinventing, 24–25 March 2022, The Telford International Centre, Telford, Shropshire. British Medical Journal Publishing Group, 2022. http://dx.doi.org/10.1136/spcare-2022-scpsc.82.

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Zharov, Vladimir P., and Alexei S. Latyshev. "Laser-acoustic transcutaneous drug delivery: A new trend in administration of drugs." In PHOTOACOUSTIC AND PHOTOTHERMAL PHENOMENA. ASCE, 1999. http://dx.doi.org/10.1063/1.58151.

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Iadanza, E., M. C. Pettenati, L. Bianchi, S. Turchi, L. Ciofi, F. Pirri, G. B. Gentili, and D. Giuli. "Telematics integrated system to perform drugs prescription and administration reducing adverse drug events." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6347381.

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SEIFFGE, D., and U. Weithmann. "SURPRISING EFFECTS OF THE CONSECUTIVE ADMINISTRATION OF PENTOXIFYLLINE AND LOW DOSE ACETYLSALICYLIC ACID ON THROMBUS FORMATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643444.

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The effect of the combined oral administration of pentoxifylline (pof) and low dose acetylsalicylic acid (ASA) was evaluated with the help of the laser-induced thrombosis model in rat mesenteric arterioles. Laser-induced thrombosis is inhibited in a dose-dependent way by both drugs. The administration of ASA, either simultaneously with or 1 hour prior to pof, does not show any effects in the laser model. On the contrary, the administration of pof followed 1 h later by ASA not onyl exhibited a significant effect but also produced a supraadditive inhibition of the laser-induced thrombus formation. Specific investigations concerning the time interval between the administration of both drugs determined that a significant effect can be achieved only after an interval of 30 to 90 minutes (principle of HWA 5112).The striking results could also be shown in diseased animals after consecutive chronic administration of pof 1 h prior to ASA. HWA 5112 exhibits significant effects on laser-induced thrombus formation in the following chronic animal models: 1. adjuvant arthritic rats, 10 → 1 mg/kg for 21 days; 2. spontaneously hypertensive stroke-prone rats, 10→ 1 mg/kg three times within 24 h; 3. cholesterol-induced atherosclerosis in rabbits, 10→ 1 mg/kg for 14 days. The reported data clearly demonstrate that the sequential drug administration of first pentoxifylline followed 30 to 90 min later by ASA exhibits a supraadditive antithrombotic effect.

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Mendes, Pedro J., Joa˜o M. M. Sousa, and Joa˜o F. Pinto. "A Virtual Apparatus for Design and Testing of New Drug Formulations and Devices for Inhalation Therapy." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38027.

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Delivery of drugs to the lungs as aerosols is regarded as an excellent route for local or systemic administration of drugs. Aerosols have been used traditionally for treating illnesses of the respiratory tract (e.g. asthma), but new perspectives and needs on inhalation therapy have recently emerged (e.g. insulin). The percentage of drug that reaches the targeted region, the so-called respirable fraction (RF), is in average only 30% of the dose provided to the patient. Thus, the development of more efficient formulations and devices remains an important issue.

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Ansari, Mohammad Javed, Aziz Unnisa, Anshul Singh, Devvret Verma, Rahul Kanaoujiya, and Jose Luis Arias Gonzales. "Application of Porous Nanomaterials for Sustained and Targeted Drug Release." In International Conference on Recent Advancements in Biomedical Engineering. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-b2484c.

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Patients must take significant doses of drugs to acquire the therapeutic effects required for disease therapy due to the absence of selectivity and accessibility of medicinal molecules. Drugs contain a range of drug carriers that are available to transport therapeutic chemicals to the targeted issues in the body. Mesoporous materials are choice for overcoming the aforementioned issues and producing effects in a predictable and long-term way. Because of its chemical characteristics, thermal stability, & biocompatibility, mesophoric nanoparticles are commonly utilized as release reagents. The innovative silica mesophore technology allows for efficient drug loading and administration after the target site has been reached. The additives used to manufacture MSNs can affect the property of mesoporous materials, including pore width, porosity, drug load, and surface characteristics. The need for an active surface provides for surface treatment as well as the coupling of therapeutic substances. They are widely employed in the bio-medical industry for diagnosis, target medication administration, bio-sensing, cellular absorption, and so on. The purpose of this study is, to sum up the existing level of information about mesoporous nanomaterials and their applications in diverse healthcare sectors.

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Taylor, Tracey, and Kate Nolan. "P-114 Single nurse administration (SNA) controlled drugs – a phased approach." In Transforming Palliative Care, Hospice UK 2018 National Conference, 27–28 November 2018, Telford. British Medical Journal Publishing Group, 2018. http://dx.doi.org/10.1136/bmjspcare-2018-hospiceabs.139.

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Pereira, Rosa, Tommy Julianto, Kah Yuen, and Abu Abdul Majeed. "Anionic Eudragit nanoparticles as carriers for oral administration of peptidomimetic drugs." In 2006 International Conference on Nanoscience and Nanotechnology. IEEE, 2006. http://dx.doi.org/10.1109/iconn.2006.340611.

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Reports on the topic "Drugs administration"

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Deng, Jianhao, jiaxing Zhang, QingXia Zhang, and Guowei Zhong. Serotonin syndrome with dextromethorphan alone and in combination with other serotonergic drugs. a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0079.

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Review question / Objective: To assess the evidence for serotonin syndrome occurring in the context of dextromethorphan administration. To assess concurrent medication to see if there are associations with 1) other serotonergic medication. Condition being studied: It is uncertain whether use of dextromethorphan alone or in therapeutic doses can cause Serotonin syndrome (SS). Also, SS by dextromethorphan has not previously been systematically reviewed. Therefore, the main aim is to present a systematic review and summary of these studies.

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Canellas, Joao Vitor, Fabio Ritto, and Paul Tiwana. Comparative efficacy and safety of pharmacological interventions to reduce inflammatory complications after mandibular third molar surgery: a systematic review and network meta-analysis protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2021. http://dx.doi.org/10.37766/inplasy2021.7.0069.

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Review question / Objective: This systematic review aims to compare the effects of different drugs to reduce postoperative inflammatory complications (pain, edema, and trismus) after mandibular third molar surgery by applying a frequentist network meta-analysis approach. To this end, the proposed study will answer the following questions: 1) Among diverse drugs currently available, which postoperative pharmacological regimen is the most efficient to reduce pain after mandibular third molar surgery? 2) Is the pre-emptive analgesia effective in reducing pain immediately after the mandibular third molar surgery? In this case, 3) Which preoperative pharmacological regimen is the most efficient? 4) Among diverse corticosteroids currently available, what is the best option to control the edema induced by the surgery? 5) What is the optimal dose and route of administration of corticosteroids prior to mandibular third molar surgery to control the pain/ edema induced by the surgery? Condition being studied: Inflammatory complications after mandibular third molar surgery (Pain, edema, and trismus).

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Shujaa, Asaad Suliman, and Qasem Almulihi. The efficacy and safety of ketamine in treating refractory and super-refractory status epilepticus in pediatric and adult populations, A systemic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0011.

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Review question / Objective: This study is to assess the efficacy and safety of ketamine in treating refractory and super-refractory status epilepticus in pediatric and adult populations. Rationale: Refractory status epilepticus (RSE) is either generalized or complex partial status epilepticus (SE) that fails to respond to first and second-line therapies. Super refractory status epilepticus (SRSE) is SE that remains unresponsive despite 24 hours of therapy with general anesthesia [1, 2]. Both RSE and SRSE pose significant challenges for the managing intensivist. There exists a race against time for control of epileptic activity in the RSE/SRSE patient to preserve cortical function and reduce morbidity/mortality. However, despite the best intentions, and not uncommonly, standard frontline antiepileptic drugs (AEDs) fail to control or reduce seizure activity once seizures approach the 30-minute mark. The following review provides an analysis of ketamine in treating RSE/SRSE, focusing on the potential target population, dosing, concerns, and the role of early administration.

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Philipson, Tomas, and Eric Sun. Is the Food and Drug Administration Safe and Effective? Cambridge, MA: National Bureau of Economic Research, October 2007. http://dx.doi.org/10.3386/w13561.

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Blanchard, A. Derived Intervention Levels for Tritium Based on Food and Drug Administration Methodology. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/4840.

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DEPARTMENT OF DEFENSE WASHINGTON DC. Application of Food and Drug Administration (FDA) Rules to Department of Defense Force Health Protection Programs. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada594572.

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Blanchard, A. Derived Intervention Levels for Tritium Based on Food and Drug Administration Methodology Using ICRP 56 Dose Coefficients. Office of Scientific and Technical Information (OSTI), June 1999. http://dx.doi.org/10.2172/7962.

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Miller, Patrice, and Alexis Williams. COVID-19’s Impact on Clinical Research. RTI Press, December 2022. http://dx.doi.org/10.3768/rtipress.2022.rb.0032.2212.

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Abstract:

During the COVID-19 pandemic, federal and state restrictions hindered many aspects of clinical trials, such as recruiting patients, which made completing required research tasks difficult or impossible. Many existing guidance documents and policies were redesigned rapidly during the pandemic to accommodate COVID-19-related emergencies. Such policies laid the foundation for change in clinical research. The purpose of this clinical research regulatory review is to determine how regulatory bodies such as the Food and Drug Administration, Office of Human Research Protections, and institutional review boards have responded to challenges in running clinical trials during the COVID-19 pandemic.

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Mark, Tami L., William N. Dowd, and Carol L. Council. Tracking the Quality of Addiction Treatment Over Time and Across States: Using the Federal Government’s “Signs” of Higher Quality. RTI Press, July 2020. http://dx.doi.org/10.3768/rtipress.2020.rr.0040.2007.

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The objective of this study was to track trends in the signs of higher-quality addiction treatment as defined by the National Institute on Drug Abuse, the National Institute on Alcohol Abuse and Addiction, and the Substance Abuse and Mental Health Services Administration. We analyzed the National Survey of Substance Abuse Treatment Services from 2007 through 2017 to determine the percent of facilities having the characteristics of higher quality. We analyzed the percent by state and over time. • We found improvements between 2007 and 2017 on most measures, but performance on several measures remained low. • Most programs reported providing evidence-based behavioral therapies. • Half or fewer facilities offered medications for opioid use disorder; mental health assessments; testing for hepatitis C, HIV, and sexually transmitted diseases; self-help groups; employment assistance; and transportation assistance. • There was significant state-level variation across the measures.

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Harrison, Robert. Oregon Physicians' Perception of the Drug Enforcement Administration's Use of Enforcement Discretion Related to the Use of Opioids in the Treatment of Chronic Pain. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6596.

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