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Relevant bibliographies by topics / Drug utilisation / Dissertations / Theses

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Dissertations / Theses on the topic 'Drug utilisation'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Bardel, Annika. "Women's health and drug utilisation /." Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8225.

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2

Darwish, Dana Abdel Bari. "Cardiovascular drug utilisation in Jordanian hospitals." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440542.

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3

Piovani, Daniele. "Determinants of drug utilisation during childhood." Thesis, Open University, 2018. http://oro.open.ac.uk/55058/.

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Paediatric pharmacology is a neglected area in terms of rational use of drugs. Wide differences have been observed in children’s exposure to drugs between and within countries and regions. The aim of the current thesis is to investigate the determinants of drug prescription in paediatrics. Pharmacoepidemiology and the use of administrative databases can be a useful tool for this scope. Data collected in regional and multiregional administrative prescription databases were analysed. Prevalence data by sex and age were calculated by dividing the number of drug users by the total number of male a

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4

Grundmark, Birgitta. "Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194297.

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Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. The studies of the present thesis concern different aspects of prostate cancer from etiological risk factors and factors influencing treatment to an improved methodology for the detection of treatment side effects. Papers I, II, both based in the population based cohort ULSAM (Uppsala Longitudin

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5

Monaghan, Mark Peter. "The turmoil of evidence : research utilisation in UK drug classification." Thesis, University of Leeds, 2008. http://etheses.whiterose.ac.uk/701/.

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This thesis investigates the thorny relationship between evidence utilisation and policy making in a heavily politicised policy area. Expectations for the conflux of researcha nd policy formulation have been consolidated in the last decade under the banner of 'evidence-based policy'. In recent times, the debateo ver the nature and utility of evidence-based policy has become much more sophisticated. No longer can the connection between evidence utilisation and policy formulation be conceived in terms of evidence shaping policy outcomes or, conversely, policy being evidence free, where evidence

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6

Bardel, Annika. "Women's Health and Drug Utilization." Doctoral thesis, Uppsala University, Department of Public Health and Caring Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8225.

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<p><b>Objectives</b>. To study medication utilization and adherence to prescribed therapy in a female population in central Sweden. To study usage of hormone replacement therapy (HRT) in this population and to assess how HRT users compare to non-users regarding symptom reporting, general health and other variables. To evaluate symptom prevalence adjusted for potential symptom affecting variables. </p><p><b>Material and methods</b>. A cross-sectional postal questionnaire study was performed in 1995 in seven counties in central Sweden. A questionnaire was sent to a random sample of 4,200 women

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7

Wright, Alison Katrina. "Examining drug utilisation patterns and optimal treatment pathways of antidiabetic medications." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/examining-drug-utilisation-patterns-and-optimal-treatment-pathways-of-antidiabetic-medications(bfef381c-583d-4747-9b8e-44cb904f48a2).html.

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Background: Type 2 Diabetes is a chronic metabolic condition which occurs as a result of insufficient insulin production and insulin resistance. This results in less glucose uptake by muscle and fat cells, allowing blood glucose levels to rise in the body. Higher blood glucose levels place patients at an increased risk of diabetes-related complications. The treatment is characterised by the initiation, switching and intensification of antidiabetic medications. The goal for patients with diabetes is to maintain glycaemic control, with blood glucose levels (HbA1c) between 6.5-7.0%(48-53mmol/mol)

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8

Burger, Solé. "A drug utilisation review of Isotretinoin in the management of acne." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/673.

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Acne is a common, chronic disorder that affects many adolescents. The most effective acne medication is systemic isotretinoin. It provides a permanent cure for many patients, but has various side effects. A South African Acne Treatment Guideline was introduced in 2005. Adherence to this guideline could lead to safer, more effective acne management. The primary aim of this study was to investigate the appropriateness of medications prescribed in the treatment of acne in South Africa, and to evaluate the safety and efficacy of systemic isotretinoin utilised by patients in the Nelson Mandela Metr

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9

Larsson, Mattias. "Antibiotic use and resistance : assessing and improving utilisation and provision of antibiotics and other drugs in Vietnam /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-630-8/.

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10

Hedna, Khedidja. "Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects." Doctoral thesis, Linköpings universitet, Avdelningen för läkemedelsforskning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122266.

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Background: Inappropriate use of medications (IUM), in particular inappropriate prescribing and non-adherence to prescribed medications, are important causes of drug-related morbidities (DRMs). They are increasing problems with the ageing populations and the growing burden of chronic conditions. However, research is needed on the association of IUMs with DRMs in outpatient settings and in the general population. Aim: The aim of this thesis is to estimate and analyse the burden of potentially inappropriate prescriptions (PIPs) in the elderly and non-adherence to long-term medications among adul

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11

Scholtz, Daniël Jacobus. "Prescribing patterns of antiretroviral drugs in the private health care sector in South Africa : a drug utilisation review / Daniël Jacobus Scholtz." Thesis, North-West University, 2005. http://hdl.handle.net/10394/1723.

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12

Sripa, Saksit. "Variation in drug utilisation and quality of prescribing across different health insurance schemes in Thailand." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203535.

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Introduction: In 2001, the Universal Coverage (UC) policy was introduced in Thailand. This policy aimed to provide equal access to health care regardless of socioeconomic status. There are now three different health care schemes serving Thai people including the Civil Servant Medical Benefit Scheme (CSMBS), the Social Security Scheme (SSS), and the UC Scheme. Soon after the introduction of the UC there was evidence of health inequalities among beneficiaries of different schemes. The purpose of this thesis is to explore the utilisation patterns of drugs and quality of prescribing across the dif

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13

Moore, Marna. "Usage analysis of dermatological products according to a medicine claims database / Marna Moore." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1026.

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A large number of people all over the world suffer from skin conditions. Dermatological problems comprise about 10 % of a general practitioner's caseload and probably more for pharmacists. The literature furthermore emphasises that skin diseases are becoming a significant problem in the developing world. There is a need to establish an effective method to achieve good health and quality of life for patients with dermatological problems. The general objective of this study was to investigate the usage patterns and cost of dermatological products in the private health care sector of South Africa

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14

Scheepers, Jenine. "A retrospective analysis of the usage patterns of antiretroviral drugs : a pharmacoeconomic approach / Jenine Scheepers." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2298.

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15

Harmzen, Magdalena Adriana. "Overview of the prescribing patterns of non-steroidal anti-inflammatory drugs : 2004-2006 / Magdalena Adriana Harmzen." Thesis, North-West University, 2008. http://hdl.handle.net/10394/3719.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for systemic control of acute and chronic pain and inflammation (Lin et ah, 2000:1129), but usage problems and side-effects that occur during the post-marketing phase of these drugs are well documented (Thiefin & Beaugerie, 2005:287). Following the demonstration of the value of anti-inflammatory therapy in diseases like rheumatoid arthritis (Boardman & Dudley Hart, 1967:268), new NSAIDs appeared on the market (Dieppe et al., 2004:867), and the indications steadily broadened from inflammatory diseases to almost any painful condition

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16

Nhokwara, Primrose Tinashe. "Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15683.

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Multi-drug resistance is increasingly becoming a challenge to tuberculosis control programmes globally. Treatment of multi-drug resistance tuberculosis (MDR-TB) includes aminoglycoside antibiotics which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients undergoing treatment for MDR-TB for early detection of ototoxic hearing loss to facilitate alerting the patients and relevant medical staff about the presence and progression of any hearing loss. Previously, models of managing patients with MDR-TB required mandatory hospitalization for at least 6 mon

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17

Katende-Kyenda, Norah Lucky. "A retrospective drug utilisation study of antimicrobials in a private primary health care group / Norah Lucky Katende-Kyenda." Thesis, North-West University, 2005. http://hdl.handle.net/10394/720.

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The commonest prescribed group of drugs is antimicrobials. Various studies have shown that they are overused globally. Since Primary health care represents the first tier of the health care system, evaluation of antimicrobial use in primary health w e settings is a necessity to ensure rational and cost-effective use of these agents in the treatment of infectious diseases. It has been reported by Hooton and Levy (2001 : 1088) that 20% to 50% of antimicrobials are inappropriately used in developing countries. According to Rebana et al. (1998: 175) the increasing overuse of antimicrobials has res

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18

Ansari, Faranak. "Evaluation and management of hospital antibiotic use." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/917390eb-a8ea-477a-8cc8-58b6babac813.

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Antimicrobials are unique drugs in that they target "infectious" or "transferable" diseases. There is considerable evidence linking increasing antimicrobial use withincreasing resistance. Resistant bacteria do not know the boundaries, either between countries or within a society between hospital and primary care. Inappropriate prescribing of antimicrobials in hospitals therefore has consequences for whole communities and problems may spread both nationally and internationally. The gathering of reliable measurements of antibiotic use in hospitals employing standardised methods is essential to b

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19

Donnelly, Neil James Public Health &amp Community Medicine Faculty of Medicine UNSW. "The use of interrupted time series analysis to evaluate the impact of Pharmaceutical Benefits Scheme policies on drug utilisation in Australia." Awarded by:University of New South Wales. Public Health and Community Medicine, 2005. http://handle.unsw.edu.au/1959.4/22509.

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PROBLEM INVESTIGATED: Methodological issues and policy implications arising from the application of interrupted time series (ITS) analyses to assess the impact of Pharmaceutical Benefit Scheme (PBS) subsidisation policies on drug utilisation in Australia. PROCEDURES FOLLOWED: A critical review of methodological issues relating to the application and analysis of ITS designs was undertaken. This included an examination of drug utilisation data sources in Australia. The PBS policies examined were: (i) the introduction of copayments in 1990; (ii) the introduction of re-supply limits in 1994 and

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20

Burger, Johanita Riétte. "A drug utilisation review of the concept of metabolic syndrome using a South African medicines claims database / Burger JR." Thesis, North-West University, 2012. http://hdl.handle.net/10394/8072.

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The aim of the study was to determine the prevalence, medicine prescribing patterns and direct treatment cost associated with the metabolic syndrome and its components in the private health care sector of South Africa. A two–dimensional research method was employed, consisting of a literature review and an empirical investigation. The objective of the literature review was to provide background to the study by conceptualising the metabolic syndrome and the components forming part thereof. The empirical investigation consisted of a descriptive, quantitative, retrospective drug utilisation revie

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Costa, Gouveia Joana. "Utilisation de nanoparticules pour le développement de nouvelles thérapies antituberculeuses." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S035/document.

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La tuberculose (TB) est un problème de santé mondiale majeur à l’origine de 10.4 millions de nouveaux cas et 1.8 millions de morts en 2015 selon l’Organisation Mondiale de la Santé (OMS). Cette maladie est causée par la bactérie Mycobacterium tuberculosis (Mtb) qui infecte principalement les poumons et se transmet par l'inhalation d’aérosols contaminés.Le traitement de TB nécessite la prise quotidienne d’antibiotiques pendant 6 mois, dont une mauvaise utilisation peut être à l’origine de l’apparition de souches Mtb multi-résistantes.La nouvelle stratégie de l’OMS, “End TB”, vise à réduire de 9

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22

Dhippayom, Teerapon. "Drug utilisation studies on the impact of the reduction of the prescription charge in Wales and the reclassification of medicines." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55716/.

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Since 2000 there have been a number of policy changes in the UK to remove barriers that limit access to medicines. Perhaps the most significant of these have been the phased reduction and abolition of the prescription charge in Wales and the efforts of the UK Government to encourage the reclassification of medicines. This thesis explored aspects of both these changes. The percent change in the number of prescription items dispensed over the two year period before and after the first reduction of the prescription charge in October 2004 was determined. There was an increase in the percent change

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23

Errico, Claudia. "Ultrasound sensitive agents for transcranial functional imaging, super-resolution microscopy and drug delivery." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC013.

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Cette thèse porte sur deux branches majeures de l'utilisation d'agents sensibles aux ultrasons: l'échographie ultrarapide du cerveau assistée par microbulles et la délivrance par ultrasons de médicaments pour la thérapie du cancer. Dans la première approche, des microbulles remplies de gaz fluoré ont été utilisés pour observer l'activation du cerveau à travers le crâne des rongeurs. Nous avons été en mesure de reconstituer de manière non invasive le réseau vasculaire du cerveau, puis de récupérer sa réponse hémodynamique avec une résolution spatio-temporelle élevée. La validation de cette appr

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24

Mouton, Jeanine. "The treatment of paediatric asthma in the private health care sector of South Africa : a retrospective drug utilisation review / J. Mouton." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4648.

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Asthma is the most common chronic disease among children worldwide. The prescribing patterns of the medication used to treat asthma in South Africa, as well as the prevalence of paediatric asthma are of interest and need to be investigated. A drug utilisation review was performed to determine the prevalence of asthma, and in particular paediatric asthma in a section of the private health care sector of South Africa. The prescribing patterns of asthma medication were investigated according to different demographic factors, such as gender, geographical area and prescriber type. Data from a medic

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Monge, Aurélien. "Création et utilisation de chimiothèques optimisées pour la recherche in silico de nouveaux composés bioactifs." Phd thesis, Université d'Orléans, 2006. http://tel.archives-ouvertes.fr/tel-00122995.

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Le choix des molécules à tester joue un rôle essentiel dans le succès d'un criblage destiné à identifier de nouveaux composés bioactifs. Les deux étapes importantes dans la préparation des molécules pour le criblage sont le choix de l'espace chimique à considérer et la sélection des molécules pertinentes dans cet espace.<br />Idéalement la préparation des composés destinés au criblage devrait se faire grâce à un logiciel dédié à cette problématique. Il n'existe cependant aucun logiciel qui soit complètement adapté. Nous avons donc entrepris le développement d'un logiciel de ce type : Screening

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Ljungberg, Christina. "Prerequisites and Responsibility for Appropriate Prescribing - the Prescribers' View." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132544.

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The overall aim of this thesis was to explore aspects of the subjective views and experiences of doctors as prescribers, focusing on responsibility for and factors of importance in achieving appropriate prescribing. To provide insights into the prescriber’s perspective the study designs were qualitative. In the first studies secondary care doctors’ perceptions of appropriate prescribing and influences in prescribing were investigated in interviews. The doctors perceived that appropriate prescribing needed continuous revision. From the perspective of the prescribers the definition of prescribin

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Bouillot, Philippe. "Copolymères diblocs amphiphiles monomethoxypolyoxyethylene-acide polylactique : synthèse et utilisation pour la fabrication de microsphères." Vandoeuvre-les-Nancy, INPL, 1997. http://www.theses.fr/1997INPL131N.

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Notre travail a porté sur la synthèse de copolymères diblocs MPOE-PLA et leur utilisation pour la préparation de systèmes de libération contrôlée, microsphères, présentant des propriétés spécifiques en raison de leur structure organisée. Nous voulions réduire l'adsorption de protéines sur la matrice en copolymère et favoriser la dégradation de celle-ci afin d'accélérer la libération du principe actif. Nous avons mis au point la synthèse de copolymères MPOE-PLA par polymérisation du lactide sur l'extrémité hydroxile du MPOE en milieu solvant et en présence d'un catalyseur, l'octoate d'étain. No

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Kimber, Joanne Public Health &amp Community Medicine Faculty of Medicine UNSW. "Role of the Sydney Medically Supervised Injecting Centre in reducing injecting drug use-related harm: evaluating accessibility, utilisation, coverage and selected health impacts." Awarded by:University of New South Wales. School of Public Health and Community Medicine, 2005. http://handle.unsw.edu.au/1959.4/23038.

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Drug Consumption Rooms (DCRs), where injecting drug users (IDUs) can use pre-obtained drugs in a hygienic and professionally supervised low threshold setting, aim to engage high risk IDUs, reduce public drug use, injecting-related morbidity and mortality, and improve access to drug treatment. This thesis evaluates the service demand, accessibility, utilisation, and coverage of Australia???s first DCR, the Sydney Medically Supervised Injecting Centre (MSIC), located in an area with a history of illegal shooting gallery operation. MSIC impact on injecting practices and injecting related health,

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29

Ledwaba, Lerato Clara. "Aspects of drug usage in a private primary health care setting : a pharmacoeconomic approach / Lerato Clara Dedwaba." Thesis, North-West University, 2004. http://hdl.handle.net/10394/80.

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In South Africa, significant changes in health care have taken place since the first democratic elections in 1994. The change had lead to a position of integrated service delivery with specific reference to primary health care. Increasingly in developing countries, the private sector impacts significantly on the rights to education and the highest attainable standard of health. Inappropriate prescribing e.g. prescribing a drug without an acceptable indication, specifying an incorrect dosage, schedule or duration of treatment, duplicating therapeutic agents and prescribing drugs without adequat

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Dombu, Youta Christophe Lionel. "Utilisation de nanoparticules pour délivrer des protéines dans les épithéliums respiratoires : caractérisation des mécanismes impliqués." Phd thesis, Université du Droit et de la Santé - Lille II, 2012. http://tel.archives-ouvertes.fr/tel-00787621.

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Utilisation de nanoparticules pour délivrer des protéines dans les épithéliums respiratoires. Caractérisation des mécanismes impliquésL'administration de médicaments par les voies respiratoires humaines est un domaine de la recherche en pleine expansion. Un effort croissant est porté sur le développement de systèmes innovants capables d'échapper aux mécanismes de clairance des voies respiratoires, d'améliorer la biodisponibilité des molécules d'intérêt, leur absorption dans la muqueuse et leur efficacité thérapeutique. Dans ce contexte, le but de ce travail était d'évaluer le potentiel de nano

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31

Lesén, Eva. "Psychotropic drugs among the elderly : Population-based studies on indicators of inappropriate utilisationin relation to socioeconomic determinants and mental disordersEva LesénGothenburg." Doctoral thesis, Nordic School of Public Health NHV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:norden:org:diva-3721.

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Background: Drug utilisation among the elderly is complex due to multiplemorbidities, extensive drug utilisation and an increased sensitivity to drugs. One of the most common drug groups utilised in this population is psychotropic drugs, which include antipsychotics, anxiolytics, hypnotics, and antidepressants. In appropriat eutilisation of drugs among the elderly is an issue of great public health importance. Aims: The overall aim of this thesis is to assess and analyse potentially in appropriat eutilisation of psychotropic drugs among the elderly in Sweden. The specific aims are to assess to

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Åkerblad, Ann-Charlotte. "Adherence to Antidepressant Medication." Doctoral thesis, Uppsala University, Department of Neuroscience, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7769.

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<p>Non-adherence to medication is a major obstacle in the treatment of depression. The objectives of the present study were to explore the effect of two interventions aiming to increase antidepressant treatment adherence, and to examine long-term consequences and costs of depression in adherent and non-adherent primary care patients. </p><p>A randomised controlled design was used to assess the respective effects of a written educational adherence enhancing programme and therapeutic drug monitoring in patients with major depression treated with sertraline for 24 weeks. All patients were prospec

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Van, der Westhuizen Elmarie. "Overview of antidepressant usage and cost 2004 until 2006 / E. van der Westhuizen." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1948.

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Kruger, Hanlie. "A review of the prescribing patterns of combination analgesics in the private health care sector / Hanlie Kruger." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1824.

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South African prescribers have a large choice of combination analgesic preparations available for prescribing. According to Desmeules et al. (2003:8) the advantages of combining analgesics include increasing the duration of analgesia, widening the spectrum of efficacy, improved patient compliance and reduced parenteral abuse potential. According to McMahon (1975:13) one of the principle arguments against fixed-dose combinations is that the physician surrenders flexibility in managing his patient. Combination analgesics may expose patients to ingredients not necessary for pain relief in their p

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Bloem, Johann. "A retrospective analysis of the prescribing patterns of hipolipidaemic drugs : a pharmacoeconomic approach / J. Bloem." Thesis, North-West University, 2009. http://hdl.handle.net/10394/4134.

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Background: More than 5.5 million South Africans aged 30 years and older are at risk of chronic disease by virtue of their triglyceride levels (Maritz, 2006:101). Dyslipidaemia is common in westernized and industrialized communities (Steyn et al., 2000:720), especially so for South Africa, where burden of disease data show dyslipidaemia to be the second most prevalent of all the chronic conditions in the country (Council for Medical Schemes, 2006:48). It is therefore no surprise that at 3.3 per cent hipolipidaemics ranked second highest based on prevalence percentage per therapeutic group in t

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Saley, Shenaaz. "The value of the "top twenty" pharmaceutical products as a management instrument in a managed health care organisation / Shenaaz Saley." Thesis, North-West University, 2004. http://hdl.handle.net/10394/428.

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Health is a fundamental human right. Access to health care, which includes providing a population with safe, effective, good quality drugs at the least possible cost, is a prerequisite to realising that right. Drugs or medicines play a fundamental role in the effectiveness, efficiency and responsiveness of health care systems. Drugs also constitute a major recurrent expense in both state-run and private sector health care. To ensure that health care workers prescribe the most cost-effective drugs through the essential drugs list, training, as well as evaluation and monitoring systems must be r

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Smit, Corlee. "Aspects of drug usage in a section of the private health care sector of South Africa : A managed health care approach / C. Smit." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4175.

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Background: According to the Council of Medical Schemes of South Africa (CMS, 2007:52), nearly seventeen percent of the total benefits paid during 2006 were for medicine. Medicine is thus a cost-driving contributor to total healthcare financing. There are various factors influencing and driving medicine usage and cost patterns, including inter alia provider preference, therapeutic committees, marketing and cost. Objectives: The purpose of this study was to identify the top twenty trade name products according to total cost and prevalence in a section of the private health care sector of South

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Dieudonné-Vatran, Antoine. "Accès à des 3‐aryl‐1(2H)‐isoquinolones via une réaction d’aminocarbonylation/cyclisation pallado catalysée : utilisation dans le développement d’agent antivasculaire inhibiteur de la sérine thréonine phosphatase I." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P615.

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Le sujet de cette thèse porte sur la synthèse d'inhibiteurs spécifique de la Sérine-Thréonine phosphatase I (PP1). Un criblage de la chimiothèque de l'institut Curie, réalisé par l'équipe du Dr. Popov a permis d'identifier une 3-aryl-1(2H)isoquinolone, qui perturbe la dynamique des microtubules et qui s’est ensuite avéré être un inhibiteur sélectif de PP1. Dans une première partie, nous avons mis au point une nouvelle méthodologie de synthèse de ces composés hétérocycliques par une réaction tandem d’aminocarbonylation-cyclisation pallado catalysée. L’étude d’une seconde voie de synthèse de ces

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Rothmann, Stephan. "Prescribing patterns of methylphenidate and atomoxetine containing products in a section of the private health care sector of South Africa / Stephan Rothmann." Thesis, North-West University, 2009. http://hdl.handle.net/10394/4905.

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The general aim of this study was to investigate the prescribing patterns of products that contain methylphenidate or atomoxetine in a section of the private health care sector of South Africa. A quantitative, retrospective drug uitilisation review was performed according to data obtained from the database of a South African medicine claims pharmacy benefit management company's for three consecutive study years (Le. 2005 to 2007). The results indicated that a total of 7,990 patients had been prescribed products that contained methylphenidate or atomoxetine in 2005. The total for 2006 was 8,57

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Laurent, Morgane. "Utilisation d'une décharge à barrière diélectrique pour développer une matrice polymère plasma dégradable pour des applications vasculaires." Thesis, Université Laval, 2017. http://www.theses.fr/2017TOU30189/document.

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Chaque année, environ 1,5 million de patients requièrent un remplacement vasculaire en réponse à une athérosclérose avancée, causant le rétrécissement interne des vaisseaux sanguins. Malheureusement, encore aujourd'hui les matériaux synthétiques utilisés pour remplacer les artères de petits diamètres (inférieurs à 6 mm) restent associés à un haut taux d'échecs, démontrant ainsi un manque de biocompatibilité certain. L'une des principales complications observées est l'hyperplasie néointimale artérielle caractérisée par l'obstruction du vaisseau sanguin due à la prolifération tridimensionnelle d

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Doyen, Camille. "Utilisation de la RMN pour la caractérisation structurale et cinétique d'associations peptide-liposome comme aide à la conception de formulation." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS110.

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L’encapsulation de principes actifs (PA) dans des liposomes est utilisée dans de nombreux domaines tels que les industries pharmaceutiques et cosmétiques. Les liposomes sont des systèmes d’administration de médicaments utilisés pour leur relargage contrôlé des PA. Pour augmenter l’efficacité de peptides comme PA, nous cherchons à optimiser des liposomes en jouant à la fois sur leur composition et la structure des peptides. Les paramètres à améliorer sont leurs interactions, l’efficacité d’encapsulation et la cinétique de relargage. Pour atteindre cet objectif, j’ai évalué l’intérêt de la spect

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Steyn, Rianda. "The usage of antidiabetic drugs : a managed care approach / Rianda Steyn." Thesis, North-West University, 2005. http://hdl.handle.net/10394/1029.

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"Diabetes mellitus" refers to a spectrum of conditions, which all present with hyperglycaemia as a common medical finding. Diabetes was once thought of as a single disease, but according to Setter et a/. (2000:378), it includes a heterogeneous group of disorders that are secondary to various genetic predispositions and precipitating factors. Type 1 diabetes mellitus (DM) accounts for 10 to 15% of all cases of diabetes mellitus and is clinically characterised by hyperglycaemia and a propensity to diabetic keto-acidosis. Its control requires chronic insulin treatment. Although it may occur at an

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Rothmann, Lourens Johannes. "Prescribing patterns of angiotensin-converting enzyme inhibitors for the period 2001 until 2006 / Lourens Johannes Rothmann." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1946.

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Eksteen, Margaritha Johanna. "Medicine usage patterns in a district hospital : a therapeutic budget model approach / Margaritha Johanna Eksteen. Part 2." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2885.

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De, Franca Carla Ermelinda. "Medicine claims in South Africa : an analysis of the prescription patterns of providers in the private health care sector / Carla Ermelinda de Franca." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4717.

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Due to the fact that the function of dispensing is not the exclusive practice of a single profession, there is much conflict surrounding the issue: it forms the crux of the pharmacy profession but it also forms part of doctors’ scope of practice. Separation of the acts of prescribing and dispensing would prevent the interest of the doctor, who has the potential to profit from selling medicines, being placed above the interest of the patient. It would, however, also affect the essential services that many dispensing doctors provide to pensioners, unemployed patients, those not covered by a medi

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Van, der Merwe Suné. "Prescribing patterns of medicines used in Parkinson's and other related diseases in the private health care sector of South Africa / S. van der Merwe." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4924.

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Parkinson's disease is the most recurrent movement disorder and has a radical effect on the lives of people. This chronic neurological disorder is accompanied by a significant social and financial burden with a negative brunt on sufferers' quality of life. The main cause of Parkinson's disease is still unknown, however, the main goal of existing treatment for Parkinson's disease is to improve the patient's quality of life and ability to go about as normally and easily as possible. The general objective of this study was to investigate the prescribing patterns of medicine items used in Parkinso

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Visser, Christoffel Dawid. "Prescribing patterns of benzodiazepines : a comparative study between two provinces in South Africa / C.D. Visser." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4925.

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Background: In 2007 the population density for the Gauteng Province was 614 persons per km2 and in the Northern Cape Province it was 2.9 persons per km2 . High population density leads to an increase in crime. This was evident in the percentage distribution of total crime reported from 2000 to 2003 of 27.4% in Gauteng Province, while the percentage distribution of total crime reported in the Northern Cape for the same period of time was 2,8%. Stress and insomnia can be caused by crime which is influenced by population density. Crime and high population density, may cause stress and fear, which

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Roux, Ilanca. "Prescribing patterns of biologic immunomodulating medicine in the South African private health care sector / Ilanca Roux." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4936.

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Advances in molecular immunology and rapid technical evolution during the past two decades have led to a new class of medicines called biologics. Recently, a large number of biologics, or biologic immunomodulators, directed towards an array of immune–mediated diseases, have entered the market. This has lead to a dramatic change in the immunotherapy of autoimmune diseases, as biologics present new potential to improve or substitute conventional immunosuppressive therapies. According to literature, biologics are used by only a small number of a health plan’s members, (approximately one per cent)

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Coetzee, Renier. "An analysis of the usage of antibiotics in the private health care sector : a managed health care approach / Renier Coetzee." Thesis, North-West University, 2004. http://hdl.handle.net/10394/91.

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The most frequent intervention performed by physicians is the writing of a prescription. Modern medicine has been remarkably effective in managing diseases. Medicines play a fundamental role in the effectiveness, efficiency and responsiveness of health care systems. However, health care expenditure is a great cause for concern and many nations around the world struggle to contain rising health care costs. Pharmaceutical benefit management programmes such as pharmacoeconomics, drug utilisation review (DUR) and disease management have emerged as control tools to ensure cost effective selection a

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Bretin, Ludovic. "Thérapie photodynamique (PDT) dans un modèle in vitro et in vivo de cancer colorectal : utilisation d'un photosensibilisateur nanovectorisé." Thesis, Limoges, 2019. http://www.theses.fr/2019LIMO0052/document.

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Le cancer colorectal (CCR) est l’un des cancers les plus diagnostiqués dans le monde mais surtout le 2ème cancerle plus mortel. Malgré les progrès de la recherche médicale dans les traitements anticancéreux, de nombreux effetssecondaires subsistent chez les patients ainsi que l’apparition de résistances aux traitements conventionnels. Ledéveloppement de nouvelles stratégies thérapeutiques anticancéreuses est donc nécessaire afin d’améliorer la priseen charge de ces patients. La thérapie photodynamique (PDT) utilisant des photosensibilisateurs (PS) se présentecomme une stratégie thérapeutique i

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