Journal articles on the topic 'Drug nanoparticles'
To see the other types of publications on this topic, follow the link: Drug nanoparticles.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Drug nanoparticles.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Wijaya, Christian J., Suryadi Ismadji, and Setiyo Gunawan. "A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals." Molecules 26, no. 3 (January 28, 2021): 676. http://dx.doi.org/10.3390/molecules26030676.
Full textAbstract:
Due to their biocompatibility, biodegradability, and non-toxicity, lignocellulosic-derived nanoparticles are very potential materials for drug carriers in drug delivery applications. There are three main lignocellulosic-derived nanoparticles discussed in this review. First, lignin nanoparticles (LNPs) are an amphiphilic nanoparticle which has versatile interactions toward hydrophilic or hydrophobic drugs. The synthesis methods of LNPs play an important role in this amphiphilic characteristic. Second, xylan nanoparticles (XNPs) are a hemicellulose-derived nanoparticle, where additional pretreatment is needed to obtain a high purity xylan before the synthesis of XNPs. This process is quite long and challenging, but XNPs have a lot of potential as a drug carrier due to their stronger interactions with various drugs. Third, cellulose nanocrystals (CNCs) are a widely exploited nanoparticle, especially in drug delivery applications. CNCs have low cytotoxicity, therefore they are suitable for use as a drug carrier. The research possibilities for these three nanoparticles are still wide and there is potential in drug delivery applications, especially for enhancing their characteristics with further surface modifications adjusted to the drugs.
2
Rajeswari, R., and R. Jothilakshmi. "Magnetic Nanoparticles as Drug Carriers: Review." Materials Science Forum 807 (November 2014): 1–12. http://dx.doi.org/10.4028/www.scientific.net/msf.807.1.
Full textAbstract:
Magnetic nanoparticles are made up of magnetic elements such as iron, nickel, cobalt and their oxides. Their unique physical and chemical properties, biocompatibility and their ability to be manipulated by external magnetic fields have made them as popular drug carriers in recent years. They offer various advantages such as ability to carry drugs to the desired areas in the body, and the ability to release the drugs in a controlled manner which in turn help in reducing side effects to other organs and in providing correct dosage of drugs. However, the complexity of the drug delivery system is a challenge in further improving the efficiency of magnetic nanoparticle drug delivery. In order to overcome this challenge, computational tools help in understanding the complexity of the drug delivery process and to design magnetic nanoparticles which are more efficient in drug delivery. In this chapter we propose to review various properties of magnetic nanoparticles, applications of magnetic nanoparticles as drug carriers, challenges in using them for drug delivery, various computational tools which aid in modeling magnetic nanoparticle drug delivery and in designing magnetic nanoparticles for efficient targeted drug delivery.
3
Sizochenko, Natalia, and Jerzy Leszczynski. "Drug-Nanoparticle Composites." Journal of Nanotoxicology and Nanomedicine 2, no. 1 (January 2017): 1–10. http://dx.doi.org/10.4018/jnn.2017010101.
Full textAbstract:
Polymeric nanoparticles represent attractive targets for the controlled delivery of therapeutic drugs. Drug-nanoparticle conjugates are convenient targets to enhance solubility and membrane permeability of drugs, prolong circulation time and minimize non-specific uptake. The behavior of drugs-loaded nanoparticles is governed by various factors. Understanding of these effects is very important for design of drug-nanoparticle systems, that could be suitable for treating the particular diseases. The aim of the current study is a complementary molecular docking followed by quantitative structure-activity relationships modeling for drugs payload on polymeric nanoparticles. Twenty-one approved drugs were considered. Docking of drugs was performed towards a simplified polymeric surface. Binding energies agreed well with the observed mass loading. Quantitative structure-activity relationships model supported this data. Effects of electronegativity and hydrophobicity were discussed. Developed model may contribute to the development of other useful nano-sized polymeric drug carriers to deliver a spectrum of therapeutic and imaging agents for medical purposes.
4
A.Asha, A. Asha, and G. S. Prabha Littis Malar. "Cytotoxicity, Antidiabetic and Anticancer Studies of Insulin and Curcumin-Loaded Polymeric Nanoparticles." Biomedical and Pharmacology Journal 15, no. 3 (September 29, 2022): 1653–61. http://dx.doi.org/10.13005/bpj/2503.
Full textAbstract:
Cytotoxicity measurement is needed for all drug-loaded nanoparticles. Because, if the nanoparticles have toxicity means, the drug-loaded polymeric nanoparticles cannot be used for the drug delivery. Generally cell viability is measured in the cytotoxicity measurement. In this work, the nanoparticle have synthesized from the natural polymeric material. These nanoparticles have been prepared using a nano-precipitation technique. Drugs, Insulin and Curcumin are added to these synthesized nanoparticles. This drug was coated on the surface of the nanoparticles to enhance the biocompatibility. These drug-loaded polymeric nanoparticles are used for the drug delivery. L929 cells have been to prove the cytotoxicity of these drug loaded polymeric nanoparticles by Neutral red assay method. From the cytotoxicity assay TPIG, TPCG and CCIG, CCCG nanoparticles are not cytotoxic. Insulin-loaded Tapioca/pectin and a Casein/chitosan nanoparticle were used to study the anti- diabetic assay. Curcumin-loaded Tapioca/pectin and Casein/Chitosan nanoparticle were used for Anti-cancer studies, by making use of Human Osteosarcoma cells (HOS). From these studies, the Insulin and Curcumin-loaded Tapioca/pectin and Casein/chitosan nanoparticles are not cytotoxic, and they can be used for drug delivery.
5
Chandra, Arun, and Nalina C. "Review on nanoparticles technology and applications based on drug delivery." IP International Journal of Comprehensive and Advanced Pharmacology 6, no. 3 (October 15, 2021): 117–20. http://dx.doi.org/10.18231/j.ijcaap.2021.021.
Full textAbstract:
This review is about nanocrystal technology and applications of nanocrystals based on drug delivery. Nanocrystal technology is applied to the drug molecules to access for good drug delivery as nano dimensioned carrier. Nanoparticle has at least one dimension smaller than 100 nanometers. The major properties of nanoparticles are increases dissolution velocity by surface area enlargement and increase in saturation solubility. Nanoparticle’s productions are done with different methods such as precipitation method, Milling method, and homogenized method. Nanoparticles has got wide range of applications based on drug delivery such as gastrointestinal tract, brain, tumor cell targeting, respiratory tract, and gene delivery.
6
Shukla, Prashant, Shweta Sharma, and Padma Rao. "Nanoparticulate drug delivery systems: A revolution in design and development of drugs." Journal of Drug Delivery and Therapeutics 11, no. 5-S (October 15, 2021): 188–93. http://dx.doi.org/10.22270/jddt.v11i5-s.5023.
Full textAbstract:
The recent developments in nanoparticle-based drug formulations have been helping to address issues around treating challenging diseases. Nanoparticles come in different sizes but usually vary between 100nm to 500nm. For the past few years there has been research going on in the area of drug delivery using particulate delivery systems. Various drug molecules have been modified for both pharmacokinetic and pharmacodynamic properties using nanoparticles as physical approach. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes.
Keywords: nanoparticles, applications in delivery, Liposomes, Dendrimers
7
Pieper, Sebastian, Hannah Onafuye, Dennis Mulac, Jindrich Cinatl, Mark N. Wass, Martin Michaelis, and Klaus Langer. "Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity." Beilstein Journal of Nanotechnology 10 (October 29, 2019): 2062–72. http://dx.doi.org/10.3762/bjnano.10.201.
Full textAbstract:
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results. To investigate whether easy-to-prepare nanoparticles made of well-tolerated polymers may circumvent transporter-mediated drug efflux, we prepared poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) nanoparticles loaded with the ABCB1 substrate doxorubicin by solvent displacement and emulsion diffusion approaches and assessed their anticancer efficiency in neuroblastoma cells, including ABCB1-expressing cell lines, in comparison to doxorubicin solution. Results: The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement led to the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH 7 reaching 53 µg doxorubicin/mg nanoparticle. These PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH 7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anticancer effects. However, nanoparticle-encapsulated doxorubicin did not display increased efficacy in ABCB1-expressing cells relative to doxorubicin solution. Conclusion: Doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anticancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anticancer efficacy. The design of drug-loaded nanoparticles with optimised anticancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells.
8
Lohcharoenkal, Warangkana, Liying Wang, Yi Charlie Chen, and Yon Rojanasakul. "Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/180549.
Full textAbstract:
Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability. They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy.
9
Mills, Hilla, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, and Thang Nguyen Van. "A Critical Scrutiny on Liposomal Nanoparticles Drug Carriers as Modelled by Topotecan Encapsulation and Release in Treating Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (August 9, 2022): 1–7. http://dx.doi.org/10.1155/2022/7702512.
Full textAbstract:
The medical field is looking for drugs and/or ways of delivering drugs without harming patients. A number of severe drug side effects are reported, such as acute kidney injury (AKI), hepatotoxicity, skin rash, and so on. Nanomedicine has come to the rescue. Liposomal nanoparticles have shown great potential in loading drugs, and delivering drugs to specific targeted sites, hence achieving a needed bioavailability and steady state concentration, which is achieved by a controlled drug release ability by the nanoparticles. The liposomal nanoparticles can be conjugated to cancer receptor tags that give the anticancer-loaded nanoparticles specificity to deliver anticancer agents only at cancerous sites, hence circumventing destruction of normal cells. Also, the particles are biocompatible. The drugs are shielded by attack from the liver and other cytochrome P450 enzymes before reaching the desired sites. The challenge, however, is that the drug release is slow by these nanoparticles on their own. Scientists then came up with several ways to enhance drug release. Magnetic fields, UV light, infrared light, and so on are amongst the enhancers used by scientists to potentiate drug release from nanoparticles. In this paper, synthesis of liposomal nanoparticle formulations (liposomal-quantum dots (L-QDs), liposomal-quantum dots loaded with topotecan (L-QD-TPT)) and their analysis (cytotoxicity, drug internalization, loading efficiency, drug release rate, and the uptake of the drug and nanoparticles by the HeLa cells) are discussed.
10
Raman, Subashini, Syed Mahmood, Ayah R. Hilles, Md Noushad Javed, Motia Azmana, and Khater Ahmed Saeed Al-Japairai. "Polymeric Nanoparticles for Brain Drug Delivery - A Review." Current Drug Metabolism 21, no. 9 (December 14, 2020): 649–60. http://dx.doi.org/10.2174/1389200221666200508074348.
Full textAbstract:
Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.
11
Katsikogianni, Georgia, and Konstantinos Avgoustakis. "Poly(lactide-co-glycolide)-Methoxy-Poly(ethylene glycol) Nanoparticles: Drug Loading and Release Properties." Journal of Nanoscience and Nanotechnology 6, no. 9 (September 1, 2006): 3080–86. http://dx.doi.org/10.1166/jnn.2006.404.
Full textAbstract:
In this work, the drug loading and in vitro release properties of PLGA-mPEG nanoparticles were studied. Three methyl-xanthine derivatives differing significantly in aqueous solubility, i.e., caffeine, theophylline, and theobromine, were employed as model drugs. Two different PLGA-mPEG copolymer compositions, namely PLGA(40)mPEG(5) and PLGA(136)mPEG(5), were included in the study. The nanoparticles were prepared by a double emulsion technique. The drug release properties of the nanoparticles in phosphate buffered saline (PBS) and in human plasma were determined. An increase of the drug proportion in the feed led to increased drug loading. The composition of the PLGA-mPEG copolymer (PLGA/mPEG molar ratio) did not appear to affect drug loading and encapsulation. Caffeine exhibited higher loading in the nanoparticles than theobromine and this exhibited a little higher loading than theophylline. Solid-state solubility of the drug in PLGA-mPEG did not affect drug loading. Drug loading and encapsulation in the PLGA-mPEG nanoparticles appeared to be governed by the partition coefficient of the drug between the organic phase and the external aqueous phase employed in nanoparticle preparation. Relatively low loading and encapsulation values were obtained, suggesting that the physical entrapment of drugs in PLGA-mPEG nanoparticles could only be an option in the development of formulations of potent drugs. Only the release of the least water-soluble theobromine was efficiently sustained by its entrapment in the nanoparticles, indicating that the physical entrapment of drugs provides the means for the development of controlled-release PLGA-mPEG nanoparticulate formulations only in the case of drugs with low aqueous solubility.
12
Liu, Ran, Gang Zhao, Shujun Wang, Yan Gu, Qi Han, and Baoan Chen. "TfR mAb-Cross-Linked Rituximab/MTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes." Journal of Nanomaterials 2019 (September 12, 2019): 1–8. http://dx.doi.org/10.1155/2019/7265450.
Full textAbstract:
Nanoparticles could enhance the drug targeted to the cancer cell by the enrichment of the drug levels, which leads to the improvement of the codelivery of both drugs for an antitumor effect. In the current study, we reported an efficient, local drug-loaded delivery strategy with a nanoparticle-loaded system. After the synthesis of Rituximab/MTX-PEG-PLL-PLGA, the transferrin receptor monoantibody (TfR mAb) was subsequently cross-linked to the nanoparticles. Compared to the traditional drug, the nanoparticle-loaded system can precisely and efficiently transport the Rituximab and Methotrexate (MTX) drug into SU-DHL-4 cells, a typical kind of B lymphocytes, which can significantly increase the cell apoptosis in the SU-DHL-4 cells. Thus, the multifunctional drug-loaded nanoparticles displayed the persistent stability and precise targeting properties, which enhanced the efficiency of anticancer efficiency in B lymphocytes.
13
Assani, Kaivon, Amy Neidhard-Doll, and Tarun Goswami. "Mechanical properties of nanoparticles in the drug delivery kinetics." Journal of Pharmaceutical and Biopharmaceutical Research 4, no. 1 (2022): 248–55. http://dx.doi.org/10.25082/jpbr.2022.01.002.
Full textAbstract:
Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the drug of choice and delivers it to the target via a targeting molecules (ex. antigen) located on the nanoparticle surface. Nanoparticles can even be targeted to deeply penetrating tissue and can be modeled to deliver drugs through the blood brain barrier. These advancements are providing better disease targeting such as to cancer and Alzheimer’s. Various polymers can be manufactured into nanoparticles. The polymers examined in this paper are polycaprolactone (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(glycolic acid) (PGA). The purpose of this study is to analyze the mechanical properties of these polymers to establish drug delivery trends and model pharmacokinetics and biotransport. We found that, in general, as the melting point, elastic modulus and tensile strength increases, the degradation rate also increases. PLA composite material may be an ideal polymer for drug delivery due to its good control of degradation.
14
Lowe, Baboucarr, Kwan-Young Chang, Jae-Ho Hwang, Jayachandran Venkatesan, Dong Gyu Kim, and Se-Kwon Kim. "Role of Chitosan nanoparticles in drug delivery." Journal of Chitin and Chitosan 21, no. 4 (December 31, 2016): 229–35. http://dx.doi.org/10.17642/jcc.21.4.1.
Full text
15
Hwang, Jimin, Sonya Mros, Allan B. Gamble, Joel D. A. Tyndall, and Arlene McDowell. "Improving Antibacterial Activity of a HtrA Protease Inhibitor JO146 against Helicobacter pylori: A Novel Approach Using Microfluidics-Engineered PLGA Nanoparticles." Pharmaceutics 14, no. 2 (February 1, 2022): 348. http://dx.doi.org/10.3390/pharmaceutics14020348.
Full textAbstract:
Nanoparticle drug delivery systems have emerged as a promising strategy for overcoming limitations of antimicrobial drugs such as stability, bioavailability, and insufficient exposure to the hard-to-reach bacterial drug targets. Although size is a vital colloidal feature of nanoparticles that governs biological interactions, the absence of well-defined size control technology has hampered the investigation of optimal nanoparticle size for targeting bacterial cells. Previously, we identified a lead antichlamydial compound JO146 against the high temperature requirement A (HtrA) protease, a promising antibacterial target involved in protein quality control and virulence. Here, we reveal that JO146 was active against Helicobacter pylori with a minimum bactericidal concentration of 18.8–75.2 µg/mL. Microfluidic technology using a design of experiments approach was utilized to formulate JO146-loaded poly(lactic-co-glycolic) acid nanoparticles and explore the effect of the nanoparticle size on drug delivery. JO146-loaded nanoparticles of three different sizes (90, 150, and 220 nm) were formulated with uniform particle size distribution and drug encapsulation efficiency of up to 25%. In in vitro microdilution inhibition assays, 90 nm nanoparticles improved the minimum bactericidal concentration of JO146 two-fold against H. pylori compared to the free drug alone, highlighting that controlled engineering of nanoparticle size is important in drug delivery optimization.
16
Ibiyeye, Kehinde M., Abu B. Z. Zuki, Norshariza Nurdin, and Mokrish Ajat. "Combine Drug Delivery of Thymoquinone-Doxorubicin by Cockle Shellderived pH-sensitive Aragonite CaCO3 Nanoparticles." Nanoscience & Nanotechnology-Asia 10, no. 4 (August 26, 2020): 518–33. http://dx.doi.org/10.2174/2210681209666190508122540.
Full textAbstract:
Background: Cockleshell-derived aragonite calcium carbonate nanoparticles were prepared by the top-down approach for combine delivery of two types of drugs. Objective: The aim of this study was to synthesize and characterize thymoquinone-doxorubicin loaded cockle shell-derived aragonite calcium carbonate nanoparticle. Aragonite calcium carbonate nanoparticles encapsulating thymoquinone and doxorubicin alone were also prepared. Methods: The blank and drug-loaded nanoparticles were characterized by field emission scanning electron microscopy, transmission electron microscopy, Zeta potential, Fourier transformed infrared and X-ray diffraction. Drug delivery properties, in vitro drug release study at pH 7.4, 6 and 4.8, and effect of blank nanoparticles on MCF10A, 3T3, MDA MB231 cells were also analyzed. Results: The blank and drug-loaded nanoparticles were pleomorphic and their sizes varying from 53.65 ± 10.29 nm to 60.49 ± 11.36 nm with an overall negative charge. The entrapment efficiency of thymoquinone and doxorubicin were 41.6 and 95.8, respectively. The FTIR showed little alteration after loading thymoquinone and doxorubicin while XRD patterns revealed no changes in the crystallizations of nanoparticles after drug loading. The drug release kinetics of doxorubicin and thymoquinone from the nanoparticles showed a continuous and gradual release after an initial burst release was observed. At pH 4.8, about 100% of drug release was noticed, 70% at pH 6 while only 50% at pH 7.4. The cell viability was 80% at a concentration of 1000 ug/ml of blank nanoparticle. Conclusion: The cockle shell-derived pH sensitive aragonite calcium carbonate nanoparticle provides an effective and simple means of multiple drug delivery and function as a platform for pH controlled release of loaded therapeutic agents.
17
Kim, Daehyun, Seung Soo Lee, Woo Young Yoo, Hyungwon Moon, Aesin Cho, So Yeon Park, Yoon-Seok Kim, Hyun Ryoung Kim, and Hak Jong Lee. "Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts." Pharmaceuticals 13, no. 9 (September 7, 2020): 235. http://dx.doi.org/10.3390/ph13090235.
Full textAbstract:
Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance the drug half-life while minimizing the associated toxicity. Nevertheless, relying solely on the enhanced half-life and enhanced permeability and retention (EPR) effects has been ineffective, and designing stimulus-sensitive nanoparticles to introduce the precise control of drug release has been desired. In this paper, we introduce a pH-sensitive, reduced albumin nanoparticle in combination with focused ultrasound treatment. Not only did these nanoparticles have superior therapeutic efficacy and toxicity profiles when compared to the free drugs in xenograft mouse models, but we were also able to show that the albumin nanoparticles reported in this paper were more suitable than other types of non-reduced albumin nanoparticles as vehicles for drug delivery. As such, we believe that the albumin nanoparticles presented in this paper with desirable characteristics including the induction of strong anti-tumor response, precise control, and superior safety profiles hold strong potential for preclinical and clinical anticancer therapy.
18
Munteanu, Cristian R., Pablo Gutiérrez-Asorey, Manuel Blanes-Rodríguez, Ismael Hidalgo-Delgado, María de Jesús Blanco Liverio, Brais Castiñeiras Galdo, Ana B. Porto-Pazos, Marcos Gestal, Sonia Arrasate, and Humbert González-Díaz. "Prediction of Anti-Glioblastoma Drug-Decorated Nanoparticle Delivery Systems Using Molecular Descriptors and Machine Learning." International Journal of Molecular Sciences 22, no. 21 (October 26, 2021): 11519. http://dx.doi.org/10.3390/ijms222111519.
Full textAbstract:
The theoretical prediction of drug-decorated nanoparticles (DDNPs) has become a very important task in medical applications. For the current paper, Perturbation Theory Machine Learning (PTML) models were built to predict the probability of different pairs of drugs and nanoparticles creating DDNP complexes with anti-glioblastoma activity. PTML models use the perturbations of molecular descriptors of drugs and nanoparticles as inputs in experimental conditions. The raw dataset was obtained by mixing the nanoparticle experimental data with drug assays from the ChEMBL database. Ten types of machine learning methods have been tested. Only 41 features have been selected for 855,129 drug-nanoparticle complexes. The best model was obtained with the Bagging classifier, an ensemble meta-estimator based on 20 decision trees, with an area under the receiver operating characteristic curve (AUROC) of 0.96, and an accuracy of 87% (test subset). This model could be useful for the virtual screening of nanoparticle-drug complexes in glioblastoma. All the calculations can be reproduced with the datasets and python scripts, which are freely available as a GitHub repository from authors.
19
Patel, J. K., and N. P. Jivani. "Chitosan Based Nanoparticles in Drug Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 2 (August 31, 2009): 517–22. http://dx.doi.org/10.37285/ijpsn.2009.2.2.4.
Full textAbstract:
Nanoparticles have gained considerable attention in recent years as one of the most promising drug delivery systems owing to their unique potentials via combining the different characteristics of hydrophilicity and hydrophobicity with a nanoparticle (e.g., very small size). Several polymeric nanoparticulate systems have been prepared and characterized in recent years, based on both natural and synthetic polymers, each with its own advantages and drawbacks. Among the natural polymers, chitosan has been studied extensively for preparation of nanoparticles. Chitosan nanoparticles have been reported with different characteristics with respect to drug delivery. This review presents various types of chitosan based nanoparticles in drug delivery.
20
Namdeo, Mini, Sutanjay Saxena, Rasika Tankhiwale, M. Bajpai, Y. M. Mohan, and S. K. Bajpai. "Magnetic Nanoparticles for Drug Delivery Applications." Journal of Nanoscience and Nanotechnology 8, no. 7 (July 1, 2008): 3247–71. http://dx.doi.org/10.1166/jnn.2008.399.
Full textAbstract:
In recent past magnetic nanoparticles have been explored for a number of biomedical applications due to their superparamagnetic moment with high magnetic saturation value. For these biomedical applications, magnetic nanoparticles require being monodispersed so that the individual nanoparticle has almost identical physico-chemical properties for biodistribution, bioelimination and contrast imaging potential. Further, the surface functionalization/modification of magnetic nanoparticles ultimately facilitate the protein or DNA separation, detection and magnetic resonance imaging contrast, drug delivery and hyperthermia applications. The essential goal of this review is to evaluate the recent advances of magnetic nanoparticles for tumor, brain targeting and hyperthermia applications.
21
Li, Dong, Yura Son, Michelle Jang, Shu Wang, and Wuqiang Zhu. "Nanoparticle Based Cardiac Specific Drug Delivery." Biology 12, no. 1 (January 4, 2023): 82. http://dx.doi.org/10.3390/biology12010082.
Full textAbstract:
Heart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles are the most commonly used vehicles for targeted drug delivery. Various nanoparticles have been synthesized to deliver drugs and other therapeutic molecules to the injured heart via passive or active targeting approaches, and their targeting specificity and therapeutic efficacies have been investigated. Here, we summarized nanoparticle-based, cardiac-specific drug delivery systems, their potency for treating heart diseases, and the mechanisms underlying these cardiac-targeting strategies. We also discussed the clinical studies that have employed nanoparticle-based cardiac-specific drug delivery.
22
Yu, Xiaojiao, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, and Zi Chen. "Design of Nanoparticle-Based Carriers for Targeted Drug Delivery." Journal of Nanomaterials 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/1087250.
Full textAbstract:
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.
23
Chavanpatil, Mahesh D., Ayman Khdair, and Jayanth Panyam. "Nanoparticles for Cellular Drug Delivery: Mechanisms and Factors Influencing Delivery." Journal of Nanoscience and Nanotechnology 6, no. 9 (September 1, 2006): 2651–63. http://dx.doi.org/10.1166/jnn.2006.443.
Full textAbstract:
Polymeric nanoparticles have demonstrated enormous potential as cellular drug delivery vehicles. Nanoparticles improve drug's stability as well as its availability and retention at the target intracellular site of action. Therapeutic efficacy of nanoparticles can be further enhanced by conjugating specific ligands to nanoparticle surface. Ligand conjugation can also be used to favorably modify the intracellular disposition of nanoparticles. A number of ligands are available for this purpose; use of a specific ligand depends on the target cell, the material used for nanoparticle formulation, and the chemistry available for ligand-nanoparticle conjugation. Cellular drug delivery using nanoparticles is also affected by clearance through the reticuloendothelial system. In this paper, we review the recent progress on our understanding of physicochemical factors that affect the cellular uptake of nanoparticles and the different cellular processes that could be exploited to enhance nanoparticle uptake into cells.
24
Xia, Dandan, Feilong Wang, Shuo Pan, Shenpo Yuan, Yunsong Liu, and Yongxiang Xu. "Redox/pH-Responsive Biodegradable Thiol-Hyaluronic Acid/Chitosan Charge-Reversal Nanocarriers for Triggered Drug Release." Polymers 13, no. 21 (October 31, 2021): 3785. http://dx.doi.org/10.3390/polym13213785.
Full textAbstract:
Biodegradable nanoparticles and micelles are promising nanosystems for the targeted delivery of potent anticancer drugs. By using specialized polymers as nanocarriers, targeted drug delivery and release can be developed. We developed thiol-hyaluronic acid (HA-SH)/chitosan (CS) nanoparticles with redox/pH dual-responsiveness via electrostatic self-assembly followed by spontaneous chemical cross-linking. The nanoparticle surface charges were reversible through different HA-SH and CS mass ratios. Doxorubicin (DOX) was used as a model drug. Dual cross-linked nanoparticles with diameters of approximately 300 nm exhibited superior stability under physiological conditions compared with nanoparticles without disulfide cross-linking. DOX was loaded more efficiently into negative nanoparticles (45.7 wt%) than positive nanoparticles (14.2 wt%). Drug release from negative nanoparticles (ζ potential of approximately −20) was higher (87.8 wt%) at pH 4.5 and in the presence of 10 mM glutathione. Positive nanoparticles (ζ potential of approximately +20) showed the same trend, but the release rate was slower than that of negative nanoparticles. DOX-loaded HA-SH/CS particles were taken up by human breast cancer cells (SKBR3), and the loaded drug was released, exhibiting potential antitumor efficacy. The HA-SH/CS nanoparticles in this study were stable under physiological conditions and are promising candidates for the targeted delivery and release of anticancer drugs.
25
Levit, Shani L., Hu Yang, and Christina Tang. "Rapid Self-Assembly of Polymer Nanoparticles for Synergistic Codelivery of Paclitaxel and Lapatinib via Flash NanoPrecipitation." Nanomaterials 10, no. 3 (March 20, 2020): 561. http://dx.doi.org/10.3390/nano10030561.
Full textAbstract:
Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP < 6) PTX and LAP into polymer nanoparticles with a coordination complex of tannic acid and iron formed during the mixing process. We determine the formulation parameters required to achieve uniform nanoparticles and evaluate the drug release in vitro. The size of the resulting nanoparticles was stable at pH 7.4, facilitating sustained drug release via first-order Fickian diffusion. Encapsulating either PTX or LAP into nanoparticles increases drug potency (as indicated by the decrease in IC-50 concentration); we observe a 1500-fold increase in PTX potency and a six-fold increase in LAP potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than treating with two single-drug-loaded nanoparticles as the combination index is 0.23 compared to 0.40, respectively.
26
Vallorz, Ernest L., David Encinas-Basurto, Rick G. Schnellmann, and Heidi M. Mansour. "Design, Development, Physicochemical Characterization, and In Vitro Drug Release of Formoterol PEGylated PLGA Polymeric Nanoparticles." Pharmaceutics 14, no. 3 (March 14, 2022): 638. http://dx.doi.org/10.3390/pharmaceutics14030638.
Full textAbstract:
Polymeric nanoparticles’ drug delivery systems represent a promising platform for targeted controlled release since they are capable of improving the bioavailability and tissue localization of drugs compared to traditional means of administration. Investigation of key parameters of nanoparticle preparation and their impact on performance, such as size, drug loading, and sustained release, is critical to understanding the synthesis parameters surrounding a given nanoparticle formulation. This comprehensive and systematic study reports for the first time and focuses on the development and characterization of formoterol polymeric nanoparticles that have potential application in a variety of acute and chronic diseases. Nanoparticles were prepared by a variety of solvent emulsion methods with varying modifications to the polymer and emulsion system with the aim of increasing drug loading and tuning particle size for renal localization and drug delivery. Maximal drug loading was achieved by amine modification of polyethylene glycol (PEG) conjugated to the poly(lactic-co-glycolic acid) (PLGA) backbone. The resulting formoterol PEGylated PLGA polymeric nanoparticles were successfully lyophilized without compromising size distribution by using either sucrose or trehalose as cryoprotectants. The physicochemical characteristics of the nanoparticles were examined comprehensively, including surface morphology, solid-state transitions, crystallinity, and residual water content. In vitro formoterol drug release characteristics from the PEGylated PLGA polymeric nanoparticles were also investigated as a function of both polymer and emulsion parameter selection, and release kinetics modeling was successfully applied.
27
Urista, Diana V., Diego B. Carrué, Iago Otero, Sonia Arrasate, Viviana F. Quevedo-Tumailli, Marcos Gestal, Humbert González-Díaz, and Cristian R. Munteanu. "Prediction of Antimalarial Drug-Decorated Nanoparticle Delivery Systems with Random Forest Models." Biology 9, no. 8 (July 30, 2020): 198. http://dx.doi.org/10.3390/biology9080198.
Full textAbstract:
Drug-decorated nanoparticles (DDNPs) have important medical applications. The current work combined Perturbation Theory with Machine Learning and Information Fusion (PTMLIF). Thus, PTMLIF models were proposed to predict the probability of nanoparticle–compound/drug complexes having antimalarial activity (against Plasmodium). The aim is to save experimental resources and time by using a virtual screening for DDNPs. The raw data was obtained by the fusion of experimental data for nanoparticles with compound chemical assays from the ChEMBL database. The inputs for the eight Machine Learning classifiers were transformed features of drugs/compounds and nanoparticles as perturbations of molecular descriptors in specific experimental conditions (experiment-centered features). The resulting dataset contains 107 input features and 249,992 examples. The best classification model was provided by Random Forest, with 27 selected features of drugs/compounds and nanoparticles in all experimental conditions considered. The high performance of the model was demonstrated by the mean Area Under the Receiver Operating Characteristics (AUC) in a test subset with a value of 0.9921 ± 0.000244 (10-fold cross-validation). The results demonstrated the power of information fusion of the experimental-centered features of drugs/compounds and nanoparticles for the prediction of nanoparticle–compound antimalarial activity. The scripts and dataset for this project are available in the open GitHub repository.
28
Matta, Vasu Deva Reddy. "A concise review on preparation methods used for the development of solid lipid nanoparticles." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 162–69. http://dx.doi.org/10.22270/jddt.v11i1-s.4687.
Full textAbstract:
Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery.
Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.
29
Xie, Chen, Chenchen Yang, Peng Zhang, Jialiang Zhang, Wei Wu, and Xiqun Jiang. "Synthesis of drug-crosslinked polymer nanoparticles." Polymer Chemistry 6, no. 10 (2015): 1703–13. http://dx.doi.org/10.1039/c4py01722f.
Full textAbstract:
A new kind of drug-crosslinked polymer nanoparticle was synthesized. The nanoparticles were composed by a phenylboronic acid modified 10-hydroxycamptothecin (the crosslinker) and 1,2-diol-rich PEG-PGMA diblock copolymer (the backbone), and crosslinked by phenylboronic ester bond.
30
Gowtham, Pemula. "Advances in Targeted Drug Delivery in Melanoma." Asian Pacific Journal of Cancer Biology 6, no. 4 (December 21, 2021): 331–37. http://dx.doi.org/10.31557/apjcb.2021.6.4.331-337.
Full textAbstract:
Cancer remains a major killer of mankind. Failure of conventional chemotherapy has resulted in recurrence and development of virulent multi drug resitant (MDR) phenotypes adding to the complexity and diversity of this deadly disease. Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally with the emergence of nanotechnology, the use of nano-carriers is widely expected to alter the landscape of melanoma treatment multifunctional nanoparticles that can integrate various key components such as drugs, genes, imaging agents and targeting ligands using unique delivery platforms would be more efficient in treating cancers. This review presents some of the important principles involved in development and novel methods of treating cancers using multifunctional-targeted nanopicles. Illustrative examples of nanoparticles engineered for drug/gene combination delivery and stimuli respnsive nanoparticle systems for cancer therapy are also discussed.
31
Hussain, Amina. "Hydrophobic Drug Release Studies from the Core/Shell Magnetic Mesoporous Silica Nanoparticles and their Anticancer Application." Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences 58, no. 1 (August 26, 2021): 77–88. http://dx.doi.org/10.53560/ppasb(58-1)646.
Full textAbstract:
Multiple therapeutic hydrophobic drugs can be delivered simultaneously by inorganic, biocompatible iron core mesoporous silica shell nanoparticles. We synthesized superparamagnetic iron oxide nanocrystals encapsulated within mesostructured silica spheres through the sol-gel process. The dose of hydrophobic drugs Paclitaxel (PTX) and Camptothecin (CPT) loading and released on Fe3 O4 @SiO2 core/shell nanoparticle detected by U.V-visible spectrophotometry using a platform of nanoparticles (NPS). After being subjected to external heating, the drug release efficiency of paclitaxel (PTX) and camptothecin (CPT) Fe3 O4 @SiO2 core/shell nanoparticles is increased. Paclitaxel (PTX) and Camptothecin (CPT) Fe3 O4 @SiO2 core/shell nanoparticles did not heat the solution when an alternating magnetic field (AMF) was applied, and there was only mild drug leakage. When compared to Fe3 O4 @MSNs, the nanoparticles (PTX) and (CPT) Fe3 O4 @MSNs function as cancer-targeting mediators, increasing the killing of PANC-1 cancer cells. Human cancer cells were given these therapeutic anticancer water-insoluble drugs with nanoparticles, which is a valuable vehicle for drug delivery, and induced the inhibition of proliferation. Therefore, the goal of this study to emphasize Fe3 O4 @SiO2 core/shell potential as a superior candidate for hydrophobic drug delivery to the PANC-1 cancer cell.
32
Zhang, Lu Jun, and Ming Yan Jiang. "Convection-Enhanced Intratumoral Nanoparticle Drug Delivery Modeling." Applied Mechanics and Materials 229-231 (November 2012): 1665–70. http://dx.doi.org/10.4028/www.scientific.net/amm.229-231.1665.
Full textAbstract:
Convection-enhanced intratumoral drug delivery has received increased attention for solid cancer therapy. With CED delivery, the advantages of the use of lipid nanoparticles carrier have been shown in many experimental cancer therapy studies. Thus, the measurement of efficiency of intratumoral nanoparticles CED becomes more and more important. Herein, an improved mathematical modeling method using modified Navier-Stokes equations to simulate nanoparticle CED delivery has been formulated. We separately modeled the delivery procedure of fluid medium (generally water) and nanoparticles. Based on mass conservation equation and Navier-Stokes equations, we constructed the model of the water medium flowing in porous tumor tissue, and then used the convection equations to describe the nanoparticle delivery procedure. Using our intratumoral nanoparticle CED model, we analyzed the effects of the links between the nanoparticle drug delivery distribution and some dominating factors. This work is helpful for predicting the drug distribution in tumor and opens up new opportunities for using computer science to help clinical tumor treatment plan.
33
Varma, Lanke Tejesh, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani, and Rahul Shukla. "Recent Advances in Self-Assembled Nanoparticles for Drug Delivery." Current Drug Delivery 17, no. 4 (June 27, 2020): 279–91. http://dx.doi.org/10.2174/1567201817666200210122340.
Full textAbstract:
The collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely different from the individual components before being ensembled. Selfassembled nanoparticles are basically a group of complex functional units that are formed by gathering the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nanotubes, liposomes and niosomes, <i>etc</i>. This self-assembly has progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of formulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from external environment and also serve as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers <i>in vivo</i>. Self-assembly is an equilibrium process where both individual and assembled components are subsisting in equilibrium. It is a bottom up approach in which molecules are assembled spontaneously, non-covalently into a stable and welldefined structure. There are different approaches that have been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle selfassembly, associated properties, and its application in therapy.
34
KAUR, CHANCHAL DEEP, GYANESH SAHU, SWARNALI DAS PAUL, HARISH SHARMA, and AJAZUDDIN . "DESIGN AND CHARACTERIZATION OF PACLITAXEL LOADED NANOPARTICLES WITH PIPERINE." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 02 (March 30, 2020): 238–43. http://dx.doi.org/10.25004/ijpsdr.2022.140213.
Full textAbstract:
Objectives: Paclitaxel is a cytotoxic drug having wonderful mechanism against cancer cells. However, it showed severe dose-limiting toxicity when administered as infusion. To overcome these side effects a suitable delivery system is highly desirable. Bioenhancers, when mixed with drugs promote and augment their bioavailability and reduced incidence of drug resistance and risk of adverse drug reaction. Therefore, we selected nanoparticles as a delivery system in this study. The object of this work was to entrap paclitaxel and herbal bioenhancer in a nanoparticle system. Materials and methods: We prepared the nanoparticles by emulsion solvent evaporation method with Eudragit RLPO polymer. The prepared nanoparticles were evaluated for particle size, zeta potential, drug entrapment, in vitro drug release. Further the nanoparticles were evaluated for in vitro cell cytotoxicity study by MTT assay on lung cancer cell line and pharmacokinetic profile. Results: The revealed good in vitro properties with 124-200 nm particle size range. All the formulations released within the range of 82.71to 95.47 % of drug in 24 h. The release kinetic of drug was best fitted to Higuchi’s model and was following Fick’s law of diffusion. All the nanoparticle batches had good drug entrapment capacity in the range of 57.51 % to 86.12%. The pure drug solution could not inhibit the cell proliferation completely but the nanoparticle formulations significantly reduced the cell proliferation in MTT assay. Surprisingly, formulation with higher bioenhancer loading (FNP 6) showed a higher antiproliferative effect on A549 cells. In in vivo pharmacokinetic assay, the plasma level of FNP-6 was highest than other formulation including control. (As shown in graphical abstract) Conclusion: The AUC of FNP-6 was 6.423µg/ml and the absolute bioavailability of FNP-6 was 7.89. FNP-5 and FNP-6 had a higher bioenhancer quantity as compare to the other formulation this may be possible reason of their higher absolute bioavailability. Therefore, it can be concluded that addition of bioenhancer with antitumor drug can enhance its prolifertive effect and bioavailability.
35
Yuan, Xudong, Ling Li, Appu Rathinavelu, Jinsong Hao, Madhusudhanan Narasimhan, Matthew He, Viviene Heitlage, Linda Tam, Sana Viqar, and Mojgan Salehi. "siRNA Drug Delivery by Biodegradable Polymeric Nanoparticles." Journal of Nanoscience and Nanotechnology 6, no. 9 (September 1, 2006): 2821–28. http://dx.doi.org/10.1166/jnn.2006.436.
Full textAbstract:
RNA interference (RNAi) is an emerging technology in which the introduction of double-stranded RNA (dsRNA) into a diverse range of organisms and cell types causes degradation of the complementary mRNA. It offers a broad spectrum of applications in both biological and medical research. Small interference RNA (siRNA) was recently explored for its therapeutical potential. However, the drug delivery of siRNA oligos is very novel and is in great need of future research. To this end, a biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle drug carrier system was prepared to load siRNA oligos with desired physicochemical properties. The nanoparticles were characterized by scanning electron microscopy and laser diffraction particle sizer. The delivery of siRNA into the targeted 293T cells was observed using fluorescent-labeled double-stranded Cy3-oligos. The model siRNA oligos, si-GFP-RNA, were also successfully loaded into PLGA nanoparticles and delivered in 293T cells. The gene silencing effect and the inhibition of GFP expression were investigated using fluorescent microscopy. Both positive and negative controls were used to compare with the new siRNA nanoparticle delivery system. It was found that nanoparticles offered both effective delivery of siRNA and prominent GFP gene silencing effect. Compared to conventional carrier systems, the new biodegradable polymeric nanoparticle system may also offer improved formulation stability, which is practically beneficial and may be used in the future clinical studies of siRNA therapeutics.
36
M. Ways, Twana Mohammed, Keng Wooi Ng, Wing Man Lau, and Vitaliy V. Khutoryanskiy. "Silica Nanoparticles in Transmucosal Drug Delivery." Pharmaceutics 12, no. 8 (August 10, 2020): 751. http://dx.doi.org/10.3390/pharmaceutics12080751.
Full textAbstract:
Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.
37
Hong, Seyoung, Dong Wook Choi, Hong Nam Kim, Chun Gwon Park, Wonhwa Lee, and Hee Ho Park. "Protein-Based Nanoparticles as Drug Delivery Systems." Pharmaceutics 12, no. 7 (June 29, 2020): 604. http://dx.doi.org/10.3390/pharmaceutics12070604.
Full textAbstract:
Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompatibility and biodegradability. Moreover, the preparation of protein nanoparticles and the corresponding encapsulation process involved mild conditions without the use of toxic chemicals or organic solvents. Protein nanoparticles can be generated using proteins, such as fibroins, albumin, gelatin, gliadine, legumin, 30Kc19, lipoprotein, and ferritin proteins, and are prepared through emulsion, electrospray, and desolvation methods. This review introduces the proteins used and methods used in generating protein nanoparticles and compares the corresponding advantages and disadvantages of each.
38
Severino, Patricia, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos, and Eliana B. Souto. "Alginate Nanoparticles for Drug Delivery and Targeting." Current Pharmaceutical Design 25, no. 11 (August 6, 2019): 1312–34. http://dx.doi.org/10.2174/1381612825666190425163424.
Full textAbstract:
Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and bioavailability, as well controlled release of drugs. The type of a nanoparticle, and its related chemical, physical and morphological properties influence its interaction with living cells, as well as determine the route of clearance and possible toxic effects. This field requires cross-disciplinary research and gives opportunities to design and develop multifunctional devices, which allow the diagnosis and treatment of devastating diseases. Over the past few decades, biodegradable polymers have been studied for the fabrication of drug delivery systems. There was extensive development of biodegradable polymeric nanoparticles for drug delivery and tissue engineering, in view of their applications in controlling the release of drugs, stabilizing labile molecules from degradation and site-specific drug targeting. The primary aim is to reduce dosing frequency and prolong the therapeutic outcomes. For this purpose, inert excipients should be selected, being biopolymers, e.g. sodium alginate, commonly used in controlled drug delivery. Nanoparticles composed of alginate (known as anionic polysaccharide widely distributed in the cell walls of brown algae which, when in contact with water, forms a viscous gum) have emerged as one of the most extensively characterized biomaterials used for drug delivery and targeting a set of administration routes. Their advantages include not only the versatile physicochemical properties, which allow chemical modifications for site-specific targeting but also their biocompatibility and biodegradation profiles, as well as mucoadhesiveness. Furthermore, mechanical strength, gelation, and cell affinity can be modulated by combining alginate nanoparticles with other polymers, surface tailoring using specific targeting moieties and by chemical or physical cross-linking. However, for every physicochemical modification in the macromolecule/ nanoparticles, a new toxicological profile may be obtained. In this paper, the different aspects related to the use of alginate nanoparticles for drug delivery and targeting have been revised, as well as how their toxicological profile will determine the therapeutic outcome of the drug delivery system.
39
Babos, György, Joanna Rydz, Michal Kawalec, Magdalena Klim, Andrea Fodor-Kardos, László Trif, and Tivadar Feczkó. "Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery." International Journal of Molecular Sciences 21, no. 19 (October 3, 2020): 7312. http://dx.doi.org/10.3390/ijms21197312.
Full textAbstract:
Dual drug-loaded nanotherapeutics can play an important role against the drug resistance and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co-encapsulated by tailor-made poly([R,S]-3-hydroxybutyrate) (PHB) using an emulsion–solvent evaporation method. Subsequent poly(ethylene glycol) (PEG) conjugation onto nanoparticles was applied to make the nanocarriers stealth and to improve their drug release characteristics. Monodisperse PHB–sorafenib–doxorubicin nanoparticles had an average size of 199.3 nm, which was increased to 250.5 nm after PEGylation. The nanoparticle yield and encapsulation efficiencies of drugs decreased slightly in consequence of PEG conjugation. The drug release of the doxorubicin was beneficial, since it was liberated faster in a tumor-specific acidic environment than in blood plasma. The PEG attachment decelerated the release of both the doxorubicin and the sorafenib, however, the release of the latter drug remained still significantly faster with increased initial burst compared to doxorubicin. Nevertheless, the PEG–PHB copolymer showed more beneficial drug release kinetics in vitro in comparison with our recently developed PEGylated poly(lactic-co-glycolic acid) nanoparticles loaded with the same drugs.
40
Jia, Lina, Peng Zhang, Hongyan Sun, Yuguo Dai, Shuzhang Liang, Xue Bai, and Lin Feng. "Optimization of Nanoparticles for Smart Drug Delivery: A Review." Nanomaterials 11, no. 11 (October 21, 2021): 2790. http://dx.doi.org/10.3390/nano11112790.
Full textAbstract:
Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects—improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles—aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.
41
Sahajwani, Ritika, Manish Srivastava, Anamika Srivastava, Chanchal Parashar, Agrima Singh, Prabhjot Kaur, and Jaya Dwivedi. "Advanced Materials in Cancer Therapy." Green Chemistry & Technology Letters 7, no. 2 (December 20, 2021): 01–17. http://dx.doi.org/10.18510/gctl.2021.721.
Full textAbstract:
The overview of this review article depends on the various techniques of formation of silver nanoparticles and different application take place in medicinal point of view.
The branch of nanotechnology plays an important role in medical science research. In this different nanoparticle is synthesized which have various application in gene delivery, drug delivery and reduce the toxic effect of drugs in the human body and also act as an antibacterial in pharmaceutical industries.
In recent days silver nanoparticles have had an important role due to their optical and catalytic properties. A large number of different particles or methods are used to prepare the different shapes of silver nanoparticles used in drug delivery. Different shapes of nanoparticles have increased their demand in various researches depend on medicinal uses. Silver nanoparticle preparation can be studied by 3 techniques related to irradiations, chemicals, bacteria, fungi, and plants.
Nanomedicine have a large number of advantages in treating various chronic diseases by using biological agents, chemotherapeutic agents, and used to deliver the drug to a specific site of the body. A silver nanoparticle is prepared for detection tool to detect the adverse effect of diseases on the target cell. Nanoparticles are used in cancer therapy to remove the damaged cell of the body.
42
Bashir, Waleed, and Sana Shahzadi. "Nanoparticles – a novel theranostic approach to treat alzheimer’s disease." Journal of Applied Biotechnology & Bioengineering 9, no. 6 (November 24, 2022): 216–20. http://dx.doi.org/10.15406/jabb.2022.09.00312.
Full textAbstract:
The incidence of Alzheimer’s disease (AD) is increasing day by day worldwide, which results in a poor quality of life. Early diagnosis and treatment of AD is necessary to suppress the progression of the disease. Conventional treatments have several limitations due to the protective blood-brain barrier. In this review, we described a nanoparticle-based approach to crossing the blood-brain barrier for AD detection and treatment. Nanoparticles encapsulate the anti-AD drug and are directed to the target tissues where controlled release of the drug takes place. There are various types of nanoparticles that are used to encapsulate drugs, including solid-based nanoparticles, liposomes, nanoemulsions, iron NPs, cerium NPs, selenium NPs, and gold NPs. In this review, we have described the use of different nanoparticles as nanomedicine. Nanoparticles are also coated with proteins and antibodies for efficient release of drugs. This review aims to provide clinical insights and the importance of nanotechnology in theranostics and describes how nanomedicine has revolutionized the drug delivery approach for AD treatment
43
Onafuye, Hannah, Sebastian Pieper, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Klaus Langer, and Martin Michaelis. "Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells." Beilstein Journal of Nanotechnology 10 (August 14, 2019): 1707–15. http://dx.doi.org/10.3762/bjnano.10.166.
Full textAbstract:
Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies. Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the neuroblastoma cell line UKF-NB-3 and its ABCB1-expressing sublines adapted to vincristine (UKF-NB-3rVCR1) and doxorubicin (UKF-NB-3rDOX20). Doxorubicin-loaded nanoparticles displayed increased anticancer activity in UKF-NB-3rVCR1 and UKF-NB-3rDOX20 cells relative to doxorubicin solution, but not in UKF-NB-3 cells. UKF-NB-3rVCR1 cells were re-sensitised by nanoparticle-encapsulated doxorubicin to the level of UKF-NB-3 cells. UKF-NB-3rDOX20 cells displayed a more pronounced resistance phenotype than UKF-NB-3rVCR1 cells and were not re-sensitised by doxorubicin-loaded nanoparticles to the level of parental cells. ABCB1 inhibition using zosuquidar resulted in similar effects like nanoparticle incorporation, indicating that doxorubicin-loaded nanoparticles successfully circumvent ABCB1-mediated drug efflux. The limited re-sensitisation of UKF-NB-3rDOX20 cells to doxorubicin by circumvention of ABCB1-mediated efflux is probably due to the presence of multiple doxorubicin resistance mechanisms. So far, ABCB1 inhibitors have failed in clinical trials probably because systemic ABCB1 inhibition results in a modified body distribution of its many substrates including drugs, xenobiotics, and other molecules. HSA nanoparticles may provide an alternative, more specific way to overcome transporter-mediated resistance.
44
Baker, Abu, Mohd Salman Khan, Muhammad Zafar Iqbal, and Mohd Sajid Khan. "Tumor-targeted Drug Delivery by Nanocomposites." Current Drug Metabolism 21, no. 8 (November 20, 2020): 599–613. http://dx.doi.org/10.2174/1389200221666200520092333.
Full textAbstract:
Background: Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the accurate nanoparticle delivery systems. Methods: Different tumor environment stimuli are responsible for triggered multistage drug delivery systems (MSDDS) for tumor therapy and imaging. Physicochemical properties, such as size, hydrophobicity and potential transform by MSDDS because of the physiological blood circulation different, intracellular tumor environment. This system accomplishes tumor penetration, cellular uptake improved, discharge of drugs on accurate time, and endosomal discharge. Results: Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also tumor tissues and sub cellular organism. Poorly soluble compounds and bioavailability issues have been faced by pharmaceutical industries, which are resolved by nanoparticle formulation. Conclusion: In our review, we illustrate different types of triggered moods and stimuli of the tumor environment, which help in smart multistage drug delivery systems by nanoparticles, basically a multi-stimuli sensitive delivery system, and elaborate their function, effects, and diagnosis.
45
Li, Chenchen, Yuqing Li, Guangzhi Li, and Song Wu. "Functional Nanoparticles for Enhanced Cancer Therapy." Pharmaceutics 14, no. 8 (August 12, 2022): 1682. http://dx.doi.org/10.3390/pharmaceutics14081682.
Full textAbstract:
Cancer is the leading cause of death in people worldwide. The conventional therapeutic approach is mainly based on chemotherapy, which has a series of side effects. Compared with traditional chemotherapy drugs, nanoparticle-based delivery of anti-cancer drugs possesses a few attractive features. The application of nanotechnology in an interdisciplinary manner in the biomedical field has led to functional nanoparticles achieving much progress in cancer therapy. Nanoparticles have been involved in the diagnosis and targeted and personalized treatment of cancer. For example, different nano-drug strategies, including endogenous and exogenous stimuli-responsive, surface conjugation, and macromolecular encapsulation for nano-drug systems, have successfully prevented tumor procession. The future for functional nanoparticles is bright and promising due to the fast development of nanotechnology. However, there are still some challenges and limitations that need to be considered. Based on the above contents, the present article analyzes the progress in developing functional nanoparticles in cancer therapy. Research gaps and promising strategies for the clinical application are discussed.
46
Bandgar, Sandip Akaram, Pranali Dhavale, Pravin Patil, Sardar Shelake, and Shitalkumar Patil. "Formulation and evaluation of prazosin hydrochloride loaded solid lipid nanoparticles." Journal of Drug Delivery and Therapeutics 8, no. 6-s (December 15, 2018): 63–69. http://dx.doi.org/10.22270/jddt.v8i6-s.2170.
Full textAbstract:
Solid Lipid Nanoparticles (SLN) are rapidly developing field of nanotechnology with several potential application in drug delivery and research. Drugs having low aqueous solubility not only give low oral bioavailability but provide high inter-and intra subject variability. The purpose of the present study was to investigate the bioavailability enhancement of Prazosin Hydrochloride drug by formulating solid lipid nanoparticle. Prazosin Hydrochloride Drug is an antihypertensive drug with limited bioavailability so that solid lipid nanoparticle (SLN) is one of the approaches to improve bioavailability. SLN were prepared using glyceryl monostearate by hot homogenization followed by Solvent emulsification-ultrasonication. Prazosin Hydrochloride loaded SLN were characterized and optimized by parameters like particle size, zeta potential, XRD, DSC. Proposing Hydrochloride loaded SLN having the particle size 263.8±1.88 and entrapment efficiency 89.29±0.65% shows better bioavailability and optimum stability in studies. The SLN studies prepared using glyceryl mono stearate as a lipid and Polaxamer 407 as a polymer leads to improve bioavailability of the drug.
Keywords: Prazosin Hydrochloride, Solid Lipid Nanoparticles, Entrapment efficiency, DSC
47
Sato, Takumi, and Yoshihiko Murakami. "Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds." Materials 15, no. 13 (July 5, 2022): 4717. http://dx.doi.org/10.3390/ma15134717.
Full textAbstract:
Most drug carriers used in pulmonary administration are microparticles with diameters over 1 µm. Only a few examples involving nanoparticles have been reported because such small particles are readily exhaled. Consequently, the development of microparticles capable of encapsulating nanoparticles and a wide range of compounds for pulmonary drug-delivery applications is an important objective. In this study, we investigated the development of polysaccharide microparticles containing nanoparticles for the temperature-responsive and two-step release of inclusions. The prepared microparticles containing nanoparticles can release two differently charged compounds in a stepwise manner. The particles have two different drug release pathways: one is the release of nanoparticle inclusions from the nanoparticles and the other is the release of microparticle inclusions during microparticle collapse. The nanoparticles can be efficiently delivered deep into the lungs and a wide range of compounds are released in a charge-independent manner, owing to the suitable roughness of the microparticle surface. These polysaccharide microparticles containing nanoparticles are expected to be used as temperature-responsive drug carriers, not only for pulmonary administration but also for various administration routes, including transpulmonary, intramuscular, and transdermal routes, that can release multiple drugs in a controlled manner.
48
S. Pragati, S. Kuldeep, S. Ashok, and M. Satheesh. "Solid Lipid Nanoparticles: A Promising Drug Delivery Technology." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 2 (August 31, 2009): 509–16. http://dx.doi.org/10.37285/ijpsn.2009.2.2.3.
Full textAbstract:
One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.
49
Sonam B Bisen. "Review on nanoparticles used in drug delivery for cancer." GSC Biological and Pharmaceutical Sciences 16, no. 1 (July 30, 2021): 062–69. http://dx.doi.org/10.30574/gscbps.2021.16.1.0194.
Full textAbstract:
Current cancer treatments include surgical intervention, radiation, and chemotherapy medications. Nanoparticles have a variety of advantages as medication delivery systems. Nanoparticles (NPs) are newly discovered methods for delivering medicines to tumour cells with little drug leakage into healthy cells. To enhance biodistribution and increase circulation duration in the bloodstream, nanoparticles have been developed with optimum size and surface properties. Here, I look at the many types and features of nanoparticles. Examples of commercially available nanocarrier-based medicines include: Therapeutic nanoparticles, the function of metal nanoparticles in cancer diagnosis and therapy, are important ideas in nanoparticle medication delivery for cancer.
50
Zein, Randa, Wissam Sharrouf, and Kim Selting. "Physical Properties of Nanoparticles That Result in Improved Cancer Targeting." Journal of Oncology 2020 (July 13, 2020): 1–16. http://dx.doi.org/10.1155/2020/5194780.
Full textAbstract:
The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target, and drug penetration into tumors is limited by abnormal vasculature and high interstitial pressure. Chemotherapy is the most common systemic treatment for cancer but can cause undesirable adverse effects, including toxicity to the bone marrow and gastrointestinal system. Therefore, nanotechnology-based drug delivery systems have been developed to reduce the adverse effects of traditional chemotherapy by enhancing the penetration and selective drug retention in tumor tissues. A thorough knowledge of the physical properties (e.g., size, surface charge, shape, and mechanical strength) and chemical attributes of nanoparticles is crucial to facilitate the application of nanotechnology to biomedical applications. This review provides a summary of how the attributes of nanoparticles can be exploited to improve therapeutic efficacy. An ideal nanoparticle is proposed at the end of this review in order to guide future development of nanoparticles for improved drug targeting in vivo.