Relevant bibliographies by topics / Drug interactions Prevention

Academic literature on the topic 'Drug interactions Prevention'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Drug interactions Prevention"

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Liekweg, A., and A. Hinnerkort. "311 Identification and prevention of drug-drug interactions." European Journal of Cancer Supplements 7, no. 2 (September 2009): 76. http://dx.doi.org/10.1016/s1359-6349(09)70264-2.

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Wittkowsky, Ann K. "Workshop: Warfarin drug interactions: Detection, prediction, prevention." Journal of Thrombosis and Thrombolysis 2, no. 4 (March 1996): 295–99. http://dx.doi.org/10.1007/bf01061915.

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Cavuto, N. J. "Pharmacies and prevention of potentially fatal drug interactions." JAMA: The Journal of the American Medical Association 275, no. 14 (April 10, 1996): 1086–87. http://dx.doi.org/10.1001/jama.275.14.1086.

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Cavuto, Nicholas John. "Pharmacies and Prevention of Potentially Fatal Drug Interactions." JAMA: The Journal of the American Medical Association 275, no. 14 (April 10, 1996): 1086. http://dx.doi.org/10.1001/jama.1996.03530380028022.

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Aliot, Etienne, and Josep Brugada. "Drug–Device Interactions." European Cardiology Review 6, no. 2 Supplement (2010): 8. http://dx.doi.org/10.15420/ecr.2010.6.2suppl.8.

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Implantable cardioverter-defibrillators (ICDs) have demonstrated utility in the prevention of sudden cardiac death. However, a fair proportion of ICD recipients commonly present with atrial fibrillation (AF), which necessitates antiarrhythmic drug (AAD) therapy to restore/maintain sinus rhythm and prevent further exacerbation of AF, which may result from the frequent co-existence of congestive heart failure. The use of AADs as an adjunctive therapy in ICD patients presents both benefits and drawbacks. Several studies have shown that AADs can reduce the incidence of inappropriate ICD discharges by modulating arrhythmias, thereby reducing symptomology and mortality rates. In these terms, some AADs may be more effective than others. It is always important to consider safety and tolerability in AAD therapy. In addition to known risks associated with sotalol in β-blocker-refractory patients and long-term amiodarone therapy, there are adverse side effects associated with AADs that can promote ICD discharge and even prevent proper ICD functioning through poor arrhythmia detection. Interest in the role of catheter ablation in ICD therapy and/or AADs is increasing owing to promising results from recent studies. However, there are many factors to consider and the potential for drug–device interactions and the resulting clinical implications must always be considered when selecting a therapeutic regimen.
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RIAZ, MUHAMMAD KASHIF. "POTENTIAL DRUG-DRUG INTERACTIONS AND STRATEGIES FOR THEIR DETECTION AND PREVENTION." FARMACIA 67, no. 4 (July 10, 2019): 572–79. http://dx.doi.org/10.31925/farmacia.2019.4.3.

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Jyotsna, M., and Y. Hemalatha. "Drug–Drug, Drug–Disease and Disease–Disease Interactions in COVID-19 with Cardiovascular Diseases (CVDs)." Indian Journal of Cardiovascular Disease in Women WINCARS 5, no. 03 (September 2020): 216–22. http://dx.doi.org/10.1055/s-0040-1716786.

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AbstractCoronaviruses are a large family of single positive-stranded, enveloped RNA viruses that can infect many animal species and humans. Human coronaviruses can be divided based on their pathogenicity. Globally so far, over nine million people have tested COVID-19 positive, of which, 4, 25,000 are in India. The FDA for the prevention or treatment of COVID-19 has approved no drugs or biologics. Numerous other antiviral agents, immunotherapies, and vaccines continue to be investigated and developed as potential therapies. Searching for effective therapies for COVID-19 infection is a complex process. The cardiovascular disease (CVD) drugs and the COVID-19 treating drugs show potent drug–drug interactions (DDI), disease–drug interactions, and disease–disease interactions.
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Nesar, Shagufta, Muhammad Harris Shoaib, Kiran Rafiq, Muhammad Azhar Mughal, Tayyaba Mumtaz, Ishrat Younus, and Arfa Akram. "Medication errors with influencing factors of polypharmacy among elderly patients using Calcium Chanel Blockers." International Journal of Endorsing Health Science Research (IJEHSR) 10, no. 2 (June 1, 2022): 144–49. http://dx.doi.org/10.29052/ijehsr.v10.i2.2022.144-149.

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Background: Geriatrics refers to age-related health changes and consequently causes complications in polypharmacy, generalizing prescribing patterns. The study aimed to investigate the pervasiveness of medication inaccuracies along with drug interactions. Methodology: Out of 450 prescriptions only 210 were selected that contained Calcium Channel Blocker (CCB) and other drugs. Drug-drug interactions were articulated by Micromedex 2.0, and the harm score was determined by National Coordinating Council for Medication Error Reporting and Prevention. Results: The outcomes revealed that 645 medication errors were identified and multiple errors were present in a single prescription. The most frequent error was unstated patient's weight (98.6%) proceeds from drug-drug interactions (66.7%). According to the harm score, 36.66% of prescriptions were placed in category D, there was a statistically significant association between the drug-drug interaction and the number of prescribed drugs (p<0.0001). Conclusion: The prime solution is that the physicians should be facilitated withal trainings about drug interactions and prescription writing skills according to WHO guidelines or other recognized standards.
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Gulick, Roy M., and Charles Flexner. "Long-Acting HIV Drugs for Treatment and Prevention." Annual Review of Medicine 70, no. 1 (January 27, 2019): 137–50. http://dx.doi.org/10.1146/annurev-med-041217-013717.

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Antiretroviral drugs have revolutionized the treatment and prevention of HIV infection; however, adherence is critical for sustained efficacy. Current HIV treatment consists of three-drug regimens, and current HIV pre-exposure prophylaxis (PrEP) consists of a two-drug regimen; both generally require adherence to once-daily dosing. Long-acting formulations are useful in the treatment and prevention of other conditions (e.g., contraceptives, antipsychotics) and help promote adherence. Newer long-acting formulations of approved and investigational antiretroviral drugs in existing and newer mechanistic classes are under study for HIV treatment and prevention, including some phase III trials. Although long-acting antiretroviral drugs hold promise, some clinical challenges exist, including managing side effects, drug-drug interactions, pregnancy, and long-lasting drug concentrations that could lead to the development of drug resistance. This review aims to summarize currently available information on long-acting antiretroviral drugs for HIV treatment and prevention.
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Baumann, P. "Drug interactions in the treatment of Bipolar disorder." European Psychiatry 26, S2 (March 2011): 2028. http://dx.doi.org/10.1016/s0924-9338(11)73731-2.

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Bipolar disorders are characterized by many different forms and episodes, which require specific pharmacological treatments. For the treatment or prevention of manic episodes, lithium salts, some atypical antipsychotic drugs and some anticonvulsants were introduced. Antidepressant drugs but also a very limited number of anticonvulsants (lamotrigine) and antipsychotic drugs (quetiapine) are recommended for the treatment of depressive episodes. In addition, benzodiazepines or related compounds may be useful as comedications for sleep problems or for their sedative properties. Polypharmacy is therefore rather common, also in case of insufficient response to a single drug, when the administration of a combination of active agents appears to be promising.Most of these drugs are substrates of cytochrome P-450, and many of them are also either inducers or inhibitors of some of its isozymes. Interactions may also occur at the level of conjugating enzymes. Increasingly, knowledge about the underlying mechanisms of drug transport from intestine to the blood, and from the blood to the brain helps to predict interactions at this level. Indeed, many drugs are transported by P-glycoprotein, and inhibitors and inducers, respectively, may modify the transport of psychotropic drugs. Therefore, it is recommended to consider the interaction profile of each drug before initiating a combined treatment and adapt medication. Sometimes, despite it is known that interactions may occur with pharmacodynamic consequences, some risky combined treatments may nevertheless be useful. In such situations, careful titration of the drug doses and therapeutic drug monitoring are recommended.
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Dissertations / Theses on the topic "Drug interactions Prevention"

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Åstrand, Bengt. "ePrescribing : Studies in Pharmacoinformatics." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-32.

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Det övergripande syftet med den här avhandlingen har varit att, inom området läkemedelsinformatik, studera utvecklingen av elektroniska stöd inom läkemedelsförskrivning; för klinisk praxis, uppföljning och forskning. Under århundraden har det handskrivna receptet varit det sätt, med vilket läkare förmedlat sina läkemedelsordinationer till apotekare, vilket också för patienten blivit en informationskälla för hur läkemedel ska användas för att göra bästa nytta. Nu genomgår receptet en förändring från pappersbaserat till elektroniskt meddelande och att anpassa en traditionell process till en ny elektronisk era innebär både möjligheter och utmaningar. Studierna som ingår i avhandlingen har visat att exponeringen av förskrivna läkemedel i en allmän befolkning har ökat under de senaste tre decennierna. Risken för potentiella interaktioner mellan läkemedel, varmed avses den risk som finns att olika läkemedel kan påverka varandras effekter och biverkningar, har också visat sig öka starkt desto fler läkemedel som används av en individ. Denna ökade samtidiga användning av flera olika läkemedel, så kallad polyfarmaci, medför att det finns en större anledning för förskrivare och farmacevter att uppmärksamma risken för potentiella interaktioner mellan läkemedel. De nyinrättade nationella receptregistren över uthämtad receptförskriven medicin bör användas bland annat för att upptäcka potentiella läkemedelsinteraktioner, såväl i vårdens utövning som inom läkemedelsepidemiologisk forskning. Den svenska läkemedelsförteckningen, som omfattar information om uthämtade receptförskrivna läkemedel för huvuddelen av den svenska befolkningen, bedöms ha en stor klinisk potential. Den enskilde individens historiska information om uthämtade läkemedel är tillgänglig för individen på Internet med hjälp av e-legitimation; även förskrivare och farmacevter på apotek kan ta del av informationen med den enskildes samtycke. Brist på tillgång till enhetliga och säkra autenticeringsmetoder inom hälso- och sjukvården kan dock fördröja tillgången på individuell läkemedelsinformation för förskrivare. I och med att de flesta recepten i Sverige nu skrivs och överförs elektroniskt är det viktigt att kvalitetsmässiga aspekter tas tillvara så att en iakttagen ökad risk för receptförskrivningsfel inte överförs i informationskedjan. Avhandlingens slutsats är att e-förskrivning, med kommunikation och användning av lagrad information om receptexpeditioner, möjliggör att läkemedelsbehandling som process kan följas och studeras på ett helt nytt
The thesis aimed to study the developments, in the area of pharmacoinformatics, of the electronic prescribing and dispensing processes of drugs - in medical praxis, follow-up, and research. For hundreds of years, the written prescription has been the method of choice for physicians to communicate decisions on drug therapy and for pharmacists to dispense medication. Successively the prescription has also become a source of information for the patient about how to use the medication to maximize its benefit. Currently, the medical prescription is at a transitional stage between paper and web, and to adapt a traditional process to the new electronic era offers both opportunities and challenges The studies in the thesis have shown that the exposure of prescribed drugs in the general population has increased considerably over three decades. The risk of receiving potentially interacting drugs was also strongly correlated to the concomitant use of multiple drugs, polypharmacy. The pronounced increase in polypharmacy over time constitutes a growing reason for prescribers and pharmacists to be aware of drug interactions. Still, there were relatively few severe potential drug interactions. Recently established national prescription registers should be evaluated for drug interaction vigilance, both clinically and epidemiologically. The Swedish National Pharmacy Register provides prescription dispensing information for the majority of the population. The medication history in the register may be accessed online to improve drug utilization, by registered individuals, prescribers, and pharmacists in a safe and secure way. Lack of widespread secure digital signatures in healthcare may delay general availability. With a relatively high prevalence of dispensed drugs in the population, the National Pharmacy Register seems justified in evaluating individual medication history. With a majority of prescriptions transferred as ePrescriptions, the detected increased risk for prescription errors warrants quality improvement, if the full potential of ePrescriptions is to be fulfilled. The main conclusion of the studies was that ePrescribing with communication of prescribed drug information, storing and retrieving dispensed drug information, offers new opportunities for clinical and scientific
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Gildenhuys, Johandie. "Interactions of quinoline antimalarial drugs with ferrihaem : structural and kinetic insights into the inhibition of malaria pigment formation." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85621.

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Thesis (PhD)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: The work in this dissertation provides structural and kinetic insight into the mechanism of action of quinoline antimalarial drugs which may aid rational drug design. Quinoline antimalarial drug-ferrihaem (Fe(III)PPIX) complexes were investigated. Single crystal Xray diffraction (SCD) structures of the complexes formed between Fe(III)PPIX and the quinoline methanol antimalarials quinine, quinidine and mefloquine have been determined, and are the first observed structures of complexes formed between free Fe(III)PPIX and quinoline antimalarial compounds. Quinine, quinidine and mefloquine are shown to have a three-point binding mode to Fe(III)PPIX, which comprises direct coordination of the drug to the Fe(III) centre through its benzylic alcohol functionality, π-stacking between the drug and porphyrin aromatic systems, and intramolecular hydrogen bond formation between the porphyrin propionate group and the protonated quinuclidine nitrogen atom of the drug in the case of quinine and quinidine, and formation of an intramolecular hydrogen bonding network in the case of mefloquine. Extended X-ray absorption fine structure spectroscopy (EXAFS) was use to elucidate structural information of Fe(III)PPIX-drug complexes in solution, and indicates that coordination persists in solution. The protocol for lipid-mediated formation of β-haematin, where monopalmitic glycerol was used as a model lipid, was successfully modified to incorporate antimalarial drugs into the aqueous layer in order to investigate drug activity under biologically-relevant conditions. Four compounds were chosen, namely chloroquine and amodiaquine, both 4- aminoquinolines and quinine and quinidine. IC50 values for the inhibition of β-haematin formation show good correlation with biological activities determined against a chloroquine-sensitive Plasmodium falciparum strain. The lipid-water interface system was further used to investigate the effects of quinine, quinidine chloroquine and amodiaquine on the kinetics of β-haematin formation. The results led to the development of a kinetic model based on the Avrami equation and the Langmuir isotherm. The data strongly support a mechanism of antimalarial drug action by adsorption to the growing face of haemozoin, with precipitation of Fe(III)PPIX at high drug concentrations accounting for decreased yields. Adsorptions constants (log Kads) determined for each drug show a strong correlation with biological activity. Finally, the first SCD structure of the μ-propionato dimer of Fe(III)PPIX, the structural unit of haemozoin, has been determined as its DMSO solvate. EXAFS suggests that this species is only formed upon nucleation, with the π-π dimer species being favoured in solution.
AFRIKAANSE OPSOMMING: Die werk in die dissertasie verleen struktuur en kinetiese insig in the meganisme van aktiwiteit vir kinolien antimalariamiddels wat kan bydra tot die ontwikkeling van nuwe medisyne. Kinolien antimalariamiddel-ferriheem (Fe(III)PPIX) komplekse was ondersoek. Navorsing is gedoen op die enkelkristal X-straaldiffraksie strukture van die komplekse gevorm tussen Fe(III)PPIX en die kinolien metanol antimalaria middels kinien, kinidien en mefloquine. Die strukture is die eerste komplekse wat waargeneem is tussen vrye Fe(III)PPIX en kinolien antimalariamiddels. Kinien, kinidien en mefloquine het ʼn driepunt bindingsvorm, direkte koördinasie met die Fe(III) deur die bensielalkohol groep, ʼn π- stapel tussen die middel en die porfirien aromatiese sisteem, ʼn intramolekulêre waterstofbinding tussen the porfirienpropionaat funksie en die geprotoneerde kinuklidien stikstofatoom (kinien en kinidien) en ʼn netwerk van intramolekulêre waterstof bindings (mefloquine) insluit. Uitgebreide X-straal absorpsie fyn struktuur spektroskopie (EXAFS) is gebruik om inligting oor Fe(III)PPIX-middel komplekse in oplossing te verkry en het aangedui dat die koördinasie in oplossing voorkom. Deur gebruik te maak van monopalmitiengliserol as die lipid in the lipid-water interfase sisteem, waar antimalariamiddels suksesvol in die buffer geïnkorporeer was, was die middel se aktiwiteit onder biologiese kondisies geondersoek. Vier middels was gekies naamlik, chloroquine en amodiaquine, albei 4-aminokinoliene en kinien en kinidien om die IC50-waarde vir inhibisie van β-hematien vorming te bepaal. Die IC50 waardes het ʼn goeie korrelasie met biologiese aktiwiteite teen die chloroquine-sensitiewe Plasmodium falciparum stam gewys. Die lipid-water interfase-sisteem was ook gebruik om die effek van kinien, kinidien, chloroquine en amodiaquine op die kineties effek op die vorming van β-hematien te ondersoek. Die resultate het gelei to die ontwikkeling van die kinetiese model gebaseer op die Avrami vergelyking en die Langmuir isoterm. Die data ondersteun ʼn meganisme van middel aksie waar die middel teen die groeiende vlak van hemosoïen kristal adsorbeer. Die neerslag van Fe(III)PPIX wat vorm by hoë konsentrasies, het gelei tot laer opbrengste. Die adsorpsiekonstante (log Kads) bepaal vir elke middel, het goeie korrelasie met biologiese aktiwiteit getoon. Enkelkristal X-straaldiffraksie strukture van μ- propionatodimeer van Fe(III)PPIX, die struktuur eenheid van hemosoïen, was bepaal as ʼn DMSO solvaat. EXAFS het aangedui dat die spesie slegs by kernvorming ontstaan en dat die π-π dimeerspesie in oplossing voorkom.
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Lindh, Ludwig, and Simon Marjanovic. "”Droger är ju olagligt så därför ska man hålla sig borta från det” : En kvalitativ studie om vad professionella uppfattar är viktigt vid det narkotikaförebyggande arbetet bland ungdomar." Thesis, Karlstads universitet, Institutionen för sociala och psykologiska studier (from 2013), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-76723.

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Syftet med studien var att undersöka vad professionella som arbetar med ungdomar uppfattar är viktigt för att kunna förebygga narkotikaanvändandet bland ungdomarna ute i samhället. Till grund för studien användes Bronfenbrenners utvecklingsekologiska modell för att kunna förstå hur ungdomarna samspelar med sin omgivning och hur ungdomarna kan påverkas av olika faktorer i sin omgivning, framförallt när det kommer till deras benägenheten av att bruka narkotika. Vi ville i denna studie ta reda på de professionellas uppfattning kring ungdomars närmiljöer i samspel med ungdomarna och dess omgivning samt hur det kan åtgärdas för att minska uppkomsten av narkotika bland dessa unga. Fem personer med olika ungdomsrelaterade yrken intervjuades där kvalitativ innehållsanalys användes för att analysera resultatet. Resultatet av studien visade att intervjupersonerna hade många liknande uppfattning kring hur problemet bör förebyggas där mycket av fokus låg på att försöka få ut informationen om vilka effekter ett narkotikabruk kan ha. Vidare nämns också vilken stor påverkan föräldrarna har på individen och hur viktigt det är att ha bra förhållande i både hemmet och med skolan samtidigt som att det är viktigt att ungdomarna inkluderas i samhället.
The purpose of the study is to investigate what aspects professionals working with youth find important in order to prevent drug use among youth. To understand to what extent the youths’ environment can influence to their use of drugs the paper uses the Bronfenbrenner’s ecological systems theory. Five people, who in different ways work with drug prevention among youth, were interviewed. Qualitative content analysis was applied. The result shows that many of the interviewees had similar perceptions on how to prevent drug use amongst youth and stressed the importance of trying to collect information on the effects of using such substances. Moreover, the interviewees expressed the significant influence that the parents have on the individual and the importance of having a good environment at home and in school as well as the importance of including youth in the society.
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Montagu, Angélique. "Composants aromatiques nano-encapsulés : une alternative face à la résistance aux antibiotiques : Démonstration des effets biologiques seuls ou nano-encapsulés de l’in vitro à l’in vivo Prevention of Bacterial Infections Using Encapsulated Phytophenolic Actives Aromatic and terpenic compounds loaded in lipidic nanocapsules: activity against multi-drug resisant Acinobacter baumannii assessed in vitro and in a murine model of sepsis Demonstration of the interactions between aromatic compound-loaded lipid nanocapsules and Acinetobacter baumannii bacterial membrane." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0072.

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Face à la montée en puissance des bactéries multi-résistantes, la découverte de nouvelles stratégies antibactériennes s’impose. Une alternative est l’utilisation de substances actives antibactériennes issues d’huiles essentielles. Ces actifs de nature lipophile, ont été encapsulés via les nanocapsules lipidiques (NCL) pour une utilisation par voie systémique. L’efficacité de ces NCL chargées en actifs a été montrée dans un modèle de sepsis à Acinetobacter baumannii avec un taux de survie de 45% à 55%. Notre étude a montré le pouvoir d’attraction et de pénétration du carvacrol (Car) encapsulé via les fonctions hydroxyles vis-à-vis de la membrane bactérienne. Les effets biologiques de ces actifs ont été caractérisés par une dégradation de l’ARNr et une surexpression des gènes codant pour des heat shock protein. Une surexpression de la catalase due au Car est également observée, en lien avec le stress oxydatif (rôle de détoxification). Nos travaux ont montré que les bactéries pourraient utiliser dans ce processus une stratégie de défense contre le Car en utilisant les ROS endogènes lors d’une réponse au stress environnemental. Ces effets biologiques sont conservés après l’encapsulation des actifs par les NCL. Dans un modèle in vivo de pneumopathie, aucune survie animale n’a été constatée, malgré la post-insertion des NCL, qui est censée augmenter leur furtivité dans le sang. L’infection pulmonaire n’a pas favorisé d’accumulation des NCL dans les poumons. Ce phénomène pourrait s’expliquer par la métabolisation du Cin en acide cinnamique dans le sang, forme oxydée de l’actif qui réduirait drastiquement l’activité antibactérienne des NCL chargées en Car-Cin
Faced with the rise of multidrug-resistant bacteria, the discovery of new antibacterial strategies is imperative. An alternative is the use of antibacterial active substances from essential oils. These lipophilic compounds were encapsulated via lipidic nanocapsules(LNC) allowing a use by systemic way. The efficacy of actives loaded LNC has been showed in a murine model of sepsis against Acinetobacter baumannii with a survival rate of 45% to 55%. Our study showed the power of attraction and penetration of the encapsulated carvacrol (Car) via the hydroxyl functions. The biological effects of these compounds were characterized by a degradation of rRNA, an over expression of genes encoding heat shock proteins. A catalase overexpression was also observed which is related to an oxidative stress (role of detoxification). Our works showed that bacteria could use in this process, a defense strategy against Car using the endogenous reactive oxygen species in response to environmental stress. These biological effects are preserved after encapsulation by LNC. In an in vivo model of pneumonia, no animal survival has been observed, despite the use of pegylated LNC, which is supposed to increase their stealth in the blood. Pulmonary infection did not promote the LNC accumulation in the lungs. This phenomenon could be explained by the metabolization of Cin in cinnamic acid in the blood, the oxidized form ofthe compound which would drastically reduce the antibacterial activity of Car-Cin loaded LNC
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Algarni, Amnah Abdullah A. 1983. "Interaction between tin/flouride-containing solutions and artificially created dental pellicles on erosion prevetion in vitro." Thesis, 2013. http://hdl.handle.net/1805/3717.

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Indiana University-Purdue University Indianapolis (IUPUI)School of dentistry
BACKGROUND: Fluoride and stannous ions have been reported to be relevant for dental erosion prevention. However, their interaction with the acquired dental pellicle (ADP), a clinically relevant erosion protective factor, is not well known and needs to be investigated. OBJECTIVES: To investigate the anti-erosive properties of fluoride-containing solutions and stannous solutions on enamel and dentin surfaces with a previously formed ADP. To characterize the protein profile of the ADP treated with the test solutions. METHODS: Phase I tested four solutions: SnCl2/NaF, NaF, SnCl2 and deionized water (DIW) (as negative control). Forty bovine enamel and dentin specimens 104 (4x4x2 mm3) were prepared and randomly distributed into 4 groups (n = 10). The specimens were incubated in clarified human saliva (CHS) for 24 h for pellicle formation and then they were subjected to a cycling procedure that included a 5-min erosive challenge (0.3-percent citric acid, pH 2.6); a 2-min treatment with the solution (between 1st, 3rd and 6th cycles); a 2-h immersion in CHS, and overnight immersion in CHS. Cycles were repeated 6x/day for 5 days. The outcome measure was surface loss (SL) using profilometry. Phase II: Thirty-two (32) bovine enamel specimens (882 mm3) (n = 8) were similarly prepared and incubated in saliva for 24 h and then treated with the solutions for 2 min followed by CHS immersion for 2 h. This cycle was repeated 3x for one day. The pellicles formed and treated with the test rinse solutions were collected, digested, and analyzed for specific protein content using liquid chromatography electrospray ionization tandem mass spectrometry (LCESI-MS/MS). RESULTS: Phase I: for enamel, SnCl2/NaF, SnCl2, NaF solutions provided 89 percent, 67 percent, and 42 percent SL reduction respectively compared with the control, while in dentin they provided 60 percent, 23 percent, and 36 percent, respectively, all significant at p < 0.05. Phase II: Seventy-two (72) common proteins were identified in all groups, 30 exclusive to DIW, 20 to SnCl2/NaF, 19 to NaF, and 13 to SnCl2. SnCl2/NaF increased the abundance of pellicle proteins than each one alone. CONCLUSION: SnCl2/NaF showed the best anti-erosive effect on both enamel and dentin. The findings suggest that the composition of acquired pellicle changes with different solutions, which may be related to their anti-erosive effect.
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Books on the topic "Drug interactions Prevention"

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Drug interactions: Protecting yourself from dangerous drug, medication, and food combinations. New York: Rosen Pub. Group, 1999.

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Harkness, Richard. The natural pharmacist: Drug-herb-vitamin interactions bible. Roseville, Calif: Prima, 2000.

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Staines, Henry M. Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Basel: Springer Basel, 2012.

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1944-, Cooper James, ed. Geriatric drug therapy interventions. New York: Pharmaceutical Products Press, 1997.

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Julian, Rosenthal C., and Rotman Marvin 1933-, eds. Infusion chemotherapy--irradiation interactions: Principles and applications to organ salvage and prevention of second primary neoplasms. New York: Elsevier, 1998.

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Aging, Illinois Alliance for. Driving, drinking, and medications: Developing a community response to older people at risk : a report on a series of roundtables. [Springfield, Ill.]: Illinois Dept. on Aging, 1995.

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R, Hawes Gene, ed. Rx for recovery: The medical and health guide for alcoholics, addicts, and their families. New York: F. Watts, 1988.

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Mindell, Earl. The vitamin bible: How the right vitamins and nutrient supplements can revolutionise your life. London: BCA, 1986.

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Mindell, Earl. The vitamin bible: How the right vitamins and nutrient supplements can revolutionise your life. 2nd ed. London: Arlington Books, 1985.

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Mindell, Earl. Earl Mindell's vitamin bible: How the right vitamins and nutrient supplements can help turn your life around. New York: Warner, 1985.

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Book chapters on the topic "Drug interactions Prevention"

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Roe, Daphne A. "Prediction and Prevention of Drug-Nutrient Interactions Using Theoretical Models." In Diet and Drug Interactions, 161–76. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-011-6047-6_9.

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Routledge, P. A. "Adverse Drug Reactions and Interactions: Mechanisms, Risk Factors, Detection, Management and Prevention." In Stephens' Detection of New Adverse Drug Reactions, 91–125. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470014199.ch2.

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Alakus, Talha Burak, and Ibrahim Turkoglu. "A Comparative Study of Amino Acid Encoding Methods for Predicting Drug-Target Interactions in COVID-19 Disease." In Modeling, Control and Drug Development for COVID-19 Outbreak Prevention, 619–43. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-72834-2_18.

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Goldstein, M. J. "The Interaction of Drug and Family Therapy in the Prevention of Relapse in Schizophrenia." In Guidelines for Neuroleptic Relapse Prevention in Schizophrenia, 55–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-86922-8_13.

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Aasland, Aadne, and Anastasia Y. Meylakhs. "Adjusting the Scope of Interaction Between State and Civil Society: HIV Prevention Among Drug Users." In Governance in Russian Regions, 43–71. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-61702-2_3.

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Thomas, David. "Drug–Nutrient Interactions." In Nutrition and Disease Prevention, 469–77. CRC Press, 2007. http://dx.doi.org/10.1201/9781420005493.ch29.

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A. Ochola, Lucy, and Eric M. Guantai. "Prevention of Hyperglycemia." In Metformin - Pharmacology and Drug Interactions. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99342.

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Hyperglycemia is the elevation of blood glucose concentrations above the normal range. Prolonged uncontrolled hyperglycemia is associated with serious life-threatening complications. Hyperglycemia arises from an imbalance between glucose production and glucose uptake and utilization by peripheral tissues. Disorders that compromise pancreatic function or affect the glucose counter-regulatory hormones cause hyperglycemia. Acute or serious illness or injury may also bring about hyperglycemia, as can many classes of drugs. Metformin lowers blood glucose levels by inhibiting the production of glucose by the liver whilst enhancing uptake of circulating glucose and its utilization in peripheral tissues such as muscle and adipose tissue. Metformin suppresses hepatic gluconeogenesis by inhibiting mitochondrial respiration and causing a reduction of cellular ATP levels. Metformin may also modulate the gut-brain-liver axis, resulting in suppression of hepatic glucose production. Metformin also opposes the hyperglycemic action of glucagon and may ameliorate pancreatic cell dysfunction associated with hyperglycemia. Metformin is therefore recommended for use in the prevention of hyperglycemia, including drug-induced hyperglycemia, in at risk patients. The benefits of metformin in the prevention of hyperglycemia are unmatched despite its contraindications.
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Naveed, Safila, and Halima Sadia. "Interaction Studies of ACE Inhibitors with Antidiabetic Drugs." In Metformin - Pharmacology and Drug Interactions. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99795.

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Angiotensin converting enzyme (ACE)-inhibitors are effective in patients with mild to moderately severe hypertension, collagen vascular and cardiovascular disease. They are also used in the prevention and treatment of myocardial infarction and in the management of cardiac arrhythmias. Patients with cardiovascular diseases are generally on multiple medicines that’s why it is imperative to study drug–drug interactions of medicines which are commonly taken together in any given case, as combined administration of different medicines can significantly influence the availability of drugs. In the present study we investigated the “in vitro” interactions of ACE inhibitors (enalapril, captopril and lisinopril) with frequently prescribed and co-administered drugs in simulated human body environments. These interactions were monitored by means of UV spectrophotometry and separation technique as RP-HPLC. Prior to start of actual drug interactions, the method of analysis of each drug was established and its various parameters validated for considering its use in testing of drug in vitro as well as in human serum. For this purpose, an attempt was made to develop a number of new HPLC methods for determination of ACE inhibitors (enalapril, captopril and lisinopril) and simultaneously with interacting drugs. These methods were optimized, validated and then successfully employed for the quantitation of enalapril, captopril and lisinopril and selected drugs in interactions studies. As a result, new methods for the quantitation of individual as well as multiple drugs were developed. The interacting drugs selected were antidiabetic drugs (metformin, glibenclamide, glimepride and pioglitazone. Interaction consequences revealed that the availability of enalapril was not affected in presence of antidiabetic drugss whereas the availability of captopril and lisinopril were altered in presence of NIDDMs.
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"Role of Nutritional Antioxidants in the Prevention and Treatment of Neurodegenerative Disorders." In Nutrient-Drug Interactions, 143–92. CRC Press, 2006. http://dx.doi.org/10.1201/9781420019131-9.

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Esposito, Ennio. "Role of Nutritional Antioxidants in the Prevention and Treatment of Neurodegenerative Disorders." In Nutrient-Drug Interactions, 129–78. CRC Press, 2006. http://dx.doi.org/10.1201/9781420019131.ch5.

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Conference papers on the topic "Drug interactions Prevention"

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Kozloff, Kenneth M., Leo I. Volakis, Joan C. Marini, and Michelle S. Caird. "Near-Infrared Imaging Reveals Site- and Age-Specific Localization of Bisphosphonate Delivery and Retention in Model of Osteogenesis Imperfecta." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205344.

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Bisphosphonate use has expanded beyond traditional applications, such as the prevention of osteoporosis, into non-traditional pediatric low bone mass diseases including osteogenesis imperfecta (OI) [1]. Despite enthusiasm, some questions remain on the overall effectiveness and implications of long-term treatment. In the Brtl/+ mouse model for OI, bisphosphonate treatment improves bone size, but bending strength fails to increase to proportionate levels and bones remain brittle [2]. Complications associated with long-term bisphosphonate treatment have been noted in other systems [3,4] leading to a need for critical information describing local drug-cell interactions responsible for these observations. The purpose of this study was to validate a fluorescent bisphosphonate analog, far-red fluorescent pamidronate (FRFP) [5] as a biomarker of bisphosphonate deposition and retention in vivo to monitor local drug concentration in a site-specific manner.
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Zhukovets, T. A., M. А. Khancheuski, I. V. Koktysh, E. I. Kvasyuk, and A. G. Sysa. "ANTIOXIDANT EFFECTS OF EMOXYPINE AS ADJUVANT OF ANTI-CANCER DRUGS." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-52-55.

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Antioxidants are known to minimize oxidative stress by interacting with free radicals produced as a result of cell aerobic reactions. Oxidative stress has long been linked to many diseases, especially tumours. Therefore, antioxidants play a crucial role in the prevention or management of free radical-related diseases. However, most of these antioxidants have anticancer effects only if taken in large doses. Therefore, the combined use of antioxidants with chemotherapeutic agents is an attractive strategy to combat various tumours. This article focuses on the antioxidant effect of emoxypine. The contribution of this molecule in enhancing the anticancer potentials of nelarabine will be demonstrated.
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Santos, Nathalia Lima Schramm dos, William Wallace dos Santos Silva, Geovanna da Silva Campos Conceição, Gabriel Serra Almeida, Jacqueline Oliveira Freitas, Breno Silva Reis, and Lucas Santos Silva. "CGRP antagonists: Perspectives on migraine prophylaxis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.193.

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Introduction: Migraine is a neurovascular disease characterized by headache attacks. Currently there are several preventive therapeutic strategies available, however some patients are not very responsive. Thus, more effective treatments have been researched, like the antagonists of the Calcitonin Gene Related Peptide, the Gepants. Objectives: To evaluate the effectiveness of Gepants in the treatment of migraine. Methods: This is an integrative literature review in the PubMed database, using the descriptors “gepants”, “migraine” and “efficacy”. Only randomized clinical trials conducted from January 2018 to September 2020 were included. Results: Twenty studies were listed, of which 17 use Gepants as a preventive treatment, 2 in acute use and 1 pharmacodynamic study. The Gepants have proved to be a viable option for patients irresponsible to the usual prophylactic regimens. Its significance in reducing migraine and associated symptoms is approximately 50% compared to the placebo group. Evidence of efficacy in the acute crisis is still insufficient. The adverse effects observed had not clinical impact, but more investigations are necessary since most studies exclude people with heart, liver and chronic kidney disease. Another limitation was the use of placebo as a control, not the current prophylactic regimens. Conclusion: This review points to Gepants as a viable option in patients with migraine resistant to the usual regimens. However, there is a need for further studies on adverse effects, comparison with current therapies, drug and pathological interactions.
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Oliveira, Ricardo F., Senhorinha F. Teixeira, Helena Maria Cabral Marques, and José Carlos Teixeira. "A Correlative CFD Study Between Recirculation Area and FPM in VHC Design." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-67329.

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A major part of asthma treatment is made by the use of preventive inhalation drugs. The Pressurized Metered-Dose Inhalator (pMDI) has been the backbone device for this treatment, due to its simplicity, portability and widely acceptance. But no device comes without its limitations, and pMDI is hard to handle properly by elders and children < 5 years old, resulting in reduced amount of drug to the patient lungs. Add-on devices (e.g. spacers) were developed to mitigate the need for coordination and reduce the oral/throat deposition, namely the Valved Holding Chambers (VHC). These devices are incorporated with a one-way valve and a chamber that allows the spray droplets to rapidly reduce their size upon release on a stagnated and confined flow. The VHC main ability, in terms of efficiency, is to reduce the coarse fraction (i.e. particles with diameter > 4.7μm) of the plume by impaction and allow the fine fraction to be inhaled by the patient. The VHC geometry will play a very importance role in the entrapment of small drug particles (i.e. fine fraction). The hypothesis proposed by this study is that a small particle has more probability to be trapped in geometries with higher recirculation areas (and stagnation zones). These macro vortices will cause a particle with small Stokes number to be entrapped; to assess this hypothesis a numerical study was modelled. The numerical study was carried out on an idealized geometry of a VHC device, using a 2D axisymmetric approach. Different coordinates for a “corner” point, were tested. FLUENT® was used to obtain the unsteady numerical solution, meshes were generated using Meshing® software from ANSYS®. Once the flow field is stabilized (around 0.6s), a pMDI spray was injected into the domain during 0.1 seconds and the simulation continued until perform 4 seconds. The simulation takes into account the vaporization of the HFA-134a propellant present in the droplets of spray and a User Defined Function (UDF) for modeling the particle -wall interaction. The post-processing of the results included the calculation of the recirculation area and the Fine Particle Mass (FPM) that exits the domain. Results show that the percentage of recirculation area decreases linearly with the increase of axial position of the corner point, and rapidly increases with the radial displacement. FPM results are not so linear; nevertheless they show opposite behavior to the recirculation area. Additionally, results show that high recirculation area reduces the amount of FPM emitted. Data can be correlated through a power function (FPM = 101.805*Area−0.244; R2 = 0.460). Results are more strongly correlated for lower values of radial displacement. The results seem to corroborate the hypothesis that smaller particles tend to be entrapped by recirculation areas.
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Rabiei, Nastaran, and Carlos Hidrovo. "Effect of Wetted Microtexturing on Friction in Microchannel Flow." In ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icnmm2020-1083.

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Abstract Microchannel flows are widely used in applications where small diffusion length scales are important. However, their inherent dimensional constrain also translates into high pumping power requirements. Inspired by nature, one possible method to reduce the large viscous pressure losses is to introduce textures in a microchannel. Depending on the interaction between the textured surface and the liquid, the microstructures can either be wetted or nonwetted. Less adhesion between solid and liquid in nonwetted state has made it popular in most of the friction reduction studies. However, in the nonwetted state, preventing liquid from penetrating into the grooves under pressurized conditions and the gas-liquid interface acting like a solid boundary open space to consider the wetted state for friction reduction as well. When dealing with the wetted state we should be aware that penetration of the flow inside the grooves can induce the pressure drag alongside the skin drag. Therefore, the wetted state will lead to a trade-off between skin and pressure drag. The aim of this work is to understand how different microtextures affect the total drag in a laminar microchannel flow. Textured microchannels with width-to-depth aspect ratios of 1, 10 and 50 and different width of the land region have been tested. In order to perform correct comparisons, the textured and baseline microchannels are designed to have the same volume. The results show that increasing the aspect ratio of the trenches introduces an extermum point in the hydraulic resistance of the microchannels. The optimum aspect ratio for the tested microchannels is 10, in which the trenches are not wide enough for streamlines to bend inside the trenches and increase the skin drag and they are not highly dense along the microchannel to reveal the negative effect of the pressure drag. On the whole, the hydraulic resistance of the textured channels is higher than the equivalent baseline for all the tested geometries.
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Apitz Castro, R., E. Ledezma, A. Jorquera, and M. K. Jain. "REVERSIBLE BLOCKADE OF PLATELET ACTIVATION DURING CARDIO-PUIMONAR BYPASS IN DOGS AFTER IV ADMINISTRATION OF AJOENE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644820.

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Surgery with extracorporeal circulation (ECC) is associated with platelet activation, which greatly contribute to prolonged postoperative bleeding and increased blood loss after surgery. Antiplatelet ccnpounds which induce rapid and reversible inhibition of platelet function, without affecting platelet adhesiveness would be potentially useful in the management of the platelet-dependent hemostatic disorder observed in ECC. Ajoene, an organosulfur originally obtained from garlic, inhibits platelet release and aggregation induced ex vivo by all know agonists. It does not affect shape change or adhesion to collagen nor interfere with metabolic pathways relevant to the platelet reaction. Ajoene action is related to its direct interaction with the fibrinogen receptor on the platelet surface which irrpairs fibrinogen binding to stimulated or chymotrypsin treated platelets. IV administration of ajoene (15 mg/Kg) to mongrel dogs, inhibits platelet aggregation induced ex vivo by collagen (2-5 g/ml) or ADP (10 M). Ccnplete inhibition is attained after 20-35min and recuperation of platelet reactivity is obtained after 2.5-3.5 hours. To study the potential benefit of ajoene for the prevention of platelet activation during cardio-pulnonary bypass, ajoene was administered to anesthesized (heparin-anticoagulated) dogs, as described above, 40min before establishing the ECC. Circulation was mantained at 1.5L/min for a period of lOOmin Platelet count, and aggregation induced esc vivo by ADP or collagen were meassured immediately before ajoene administration, lOmin after the end of ECC and thereafter, hourly. Platelet count lOmin after end of ECC, in ncn-treated dogs fell to about 57% of prepump values, while in ajoene-treated animals circulating platelets represented 80% of pre-ECC values. Recovery of platelet function in ajoene-treated dogs started 2 hr after end of ECC (about 4 hr. after ajoene administration) reaching 70% 4 hr after end of ECC. Surgical bleeding in treated-dogs was not different frrm controls. Moderate bradicardia and hypotension, which in atrqpi-nized dogs returned to normal values within 3 min was observed. Although detailed pharmacological studies are still needed, our results suggest that ajoene is a potentially useful drug for the prevention of platelet activation induced by ECC.
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Lukinović, Mario, Larisa Jovanović, and Vladimir Šašo. "CHALLENGES IN MANAGING INTELLECTUAL PROPERTY RIGHTS DURING CORONAVIRUS PANDEMIC." In Fourth International Scientific Conference ITEMA Recent Advances in Information Technology, Tourism, Economics, Management and Agriculture. Association of Economists and Managers of the Balkans, Belgrade, Serbia, 2020. http://dx.doi.org/10.31410/itema.2020.239.

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The socio-economic impact of the pandemic on all social spheres is huge, but like any crisis, for some it is an opportunity to create, develop and promote solutions. The coronavirus pandemic has brought many changes. It has forced us all to find new ways of working, interacting and living. The field of intellectual property is particularly affected by the coronavirus pandemic, its strong influence has affected all branches of intellectual property, especially the field of copyright and patents. During the COVID-19 Pandemic, numerous anomalies in the consumption of copyrights were observed, which coincided with the isolation measures, from drastically increased consumption of illegal pirated content via the Internet, especially in countries with lockdown, through a sharp increase of Disney+ and Netflix streaming platform users. The identification of products that have the word Corona in their name – in their trademark, with the virus has led to a sharp drop in consumption of some products, but also to increased sales of others. The pharmaceutical industry has invested huge funds in the fight against this global challenge, especially in the field of treatment of viruses, new drugs for the prevention, as well as finding a vaccine against COVID-19. This paper discusses the challenges faced by the management of intellectual property rights and potential response measures.
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Ko, S. H., D. L. Rhode, and Z. Guo. "Computed Effects of Rim Seal Clearance and Cavity Width on Thermal Distributions." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-419.

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Axisymmetric solutions of the Reynolds averaged Navier-Stokes equations were obtained for the complete momentum/thermal interaction at the interface between the turbine hot mainstream and rim seal flow regions. Specifically, the 2-D, axisymmetric, fully elliptic form of the equations was solved in order to obtain detailed insight concerning the effect of the rim seal clearance and cavity width on the disk temperature, gap recirculation zone GRZ and rotational drag. The mainstream and purge flow rates, pressures and temperatures were selected to match those of a typical commercial engine. The details of seven generic geometries, consisting of different seal clearance gaps and different cavity widths, for each of several cooling flow rates are analyzed. Of particular interest is the result that halving the engine nominal axial clearance of the generic rim seal is not sufficient for preventing the appearance of the GRZ. However, reducing this clearance to 25% of the nominal value does prevent its formation, and in that case the coolant flow continues outward along the disk surface through the rim seal region. In addition, the first-order characteristics of: (a) the heat transport in the rim seal region and (b) the disk temperature rise due to thermal transport via the rim seal (gap) recirculation zone and via disk frictional heating were illuminated. Further, it is concluded that smaller seal clearances are desirable for reducing rotational drag as well as purge flow rates.
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Tsukimata, Márcio Yutaka, Bianca Lumi Inomata da Silva, and Jennison Alves Guimarães. "Açaí: potential anticonvulsant agent." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.064.

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Background: Convulsion is an involuntary contraction of skeletal muscles. When considering vulnerable populations exposed to the mentioned pathophysiological situation, it is recognized that many of them will not have access to the indicated pharmacological treatment. Therefore, the ingestion of açai, Euterpe oleracea (EO) attenuates the problem, acting as an anticonvulsant. Objectives: evaluate the EO as an anticonvulsant agent. Design and setting: It is a bibliographic research and the data collection was done from the PubMed and Scielo databases. Methods: The descriptor used was “Euterpe oleracea” and the inclusion criteria adopted were: articles published in the last five years, available in full and publications related to epilepsy. Results: The EO acts on the GABAergic system when interacting occurs with the GABA receptor of cortical neurons and, above all, of astrocytes in an inhibitory mechanism for the uptake of the neurotransmitter GABA, that accumulates in the synaptic cleft, preventing the exaggerated neurotransmission that causes convulsions. In pentylenetetrazol-induced seizure (PTZ), EO showed some results similar to diazepam: reduced duration of tonic-clonic convulsion and increased latencies for the first myoclonic spasm and for the first generalized tonic-clonic seizure. Conclusions: Studies suggest that EO can be classified as an anticonvulsant, considering its inhibitory activity during synapses. Furthermore, the consumption of EO is more viable at a socioeconomic level compared to traditional drug treatments.
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