Dissertations / Theses on the topic 'Drug imaging'
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Blazek, Almira. "NMR imaging investigations of swelling-controlled drug delivery." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34513.pdf.
Full textTrim, Paul James. "MALDI-MS imaging for direct drug distribution analysis." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20455/.
Full textChen, Chen. "Quantitative magnetic resonance imaging studies of extended drug release systems." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708155.
Full textGade, Terence Peter Ferrante. "Integrated imaging of drug delivery : a molecular imaging approach to the optimization of cancer therapy /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1432803381&sid=12&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Full textSauer, Anna Magdalena. "Live-cell imaging of drug delivery by mesoporous silica nanoparticles." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138222.
Full textSeptiadi, Dedy. "Optical imaging and drug delivery using soft- and hard- nanomaterials." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF036/document.
Full textThe work described in this thesis focuses on the development of soft- and hard-materials as well as their interaction with biological cells for applications in the field of theranostics covering imaging, sensing, and gene, and cancer therapy. In this context, we first investigated the use of phosphorescent self-assembled platinum(II) complexes as cellular probes. We extended the concept stimulated emission-based bioimaging by generating a laser-like emission coming from a single biological cell without using any conventional optical cavity. In addition, we successfully developed multifunctional nanocarriers based on porous hard materials, namely zeolites-L and mesoporous silica nanoparticles for drug and oligonucleotide delivery in vitro and they were tested to treat glioblastoma. Another nanovector, which is constructed from biodegradable silica, was also synthesized and its ability to encapsulate proteins and release them in living cells upon degradation of the structure in reductive environment was demonstrated. Finally, the use of novel plasmonic structures based on breakable silica-coated silver nanoparticles for detection of reducing agents was successfully investigated
Tang, Jingjie. "Innovative imaging systems and novel drug candidates for cancer therapy." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4021.
Full textCancer is one of the leading causes of death in the world, and remains a difficult disease to treat because of poor prognosis, rapid tumor metastasis and drug resistance. Therefore, innovative imaging modalities for early and precise diagnosis as well as new anticancer drug candidates with novel mechanisms to overcome drug resistance are in high demand. The aim of my PhD research project was to contribute to this goal.The first part of my PhD thesis was focused on establishing sensitive and precise imaging systems for cancer detection using innovative nanotechnology to deliver imaging agents specifically into tumor lesions. We designed and constructed novel amphiphilic dendrimers to carry different imaging agents for PET/SPECT imaging, magnetic resonance imaging and optical fluorescence imaging. These innovative imaging systems were prepared by either encapsulation of small imaging probes within the dendrimer nanomicelles, or functionalization of the dendrimer hydrophilic surface or hydrophobic tail. The second part of my PhD program aimed to develop new anticancer drug candidates with novel mechanisms for better anticancer activity. Therefore, we designed and synthesized a series of challenging arylvinyltriazole nucleosides via the oxidative Heck reaction, which allowed us to obtain the desired compounds with excellent substrate scope and unique stereoselectivity
Varela, Aramburu Silvia [Verfasser]. "Carbohydrate-based Nanomaterials for Imaging and Drug Delivery / Silvia Varela Aramburu." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/117663254X/34.
Full textEwing, Andrew. "ATR-FTIR spectroscopic imaging to study drug release and tablet dissolution." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/51556.
Full textZhang, Rui. "Ionic Copolymer-Magnetite Complexes for Magnetic Resonance Imaging and Drug Delivery." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73648.
Full textMaster of Science
Kim, Heekyong Stephanie. "Analysis of drug delivery in the eye using magnetic resonance imaging." College Park, Md.: University of Maryland, 2007. http://hdl.handle.net/1903/7650.
Full textThesis research directed by: Dept. of Chemical and Biomolecular Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Johnston, Alexander Henderson. "Novel approaches to dendrimer based radiopharmaceutical imaging agents and drug delivery systems." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582662.
Full textPothayee, Nipon. "Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/24355.
Full textPh. D.
Wen, Amy M. "Engineering Virus-Based Nanoparticles for Applications in Drug Delivery, Imaging, and Biotechnology." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1452954511.
Full textPerumal, Meg. "Positron emission tomography imaging of platinum resistant ovarian cancer and drug modulation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10532.
Full textSauer, Anna Magdalena [Verfasser], and CHRISTOPH [Akademischer Betreuer] BRAEUCHLE. "Live-cell imaging of drug delivery by mesoporous silica nanoparticles : Drug loading, pore sealing, cellular uptake and controlled drug release / Anna Magdalena Sauer. Betreuer: Christoph Bräuchle." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1018847219/34.
Full textMezzanotte, Laura <1982>. "Bioanalytical applications of multicolour bioluminescence imaging: new tools for drug discovery and development." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3536/.
Full textBalderstone, Lucy Anne. "Use of fluorescent imaging to monitor drug responses in mouse models of tumourigenesis." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17859.
Full textFlinders, Bryn. "The use of MALDI-MS for imaging drug disposition in respiratory disease models." Thesis, Sheffield Hallam University, 2013. http://shura.shu.ac.uk/19652/.
Full textGuduru, Rakesh. "Bionano Electronics: Magneto-Electric Nanoparticles for Drug Delivery, Brain Stimulation and Imaging Applications." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/979.
Full textErrico, Claudia. "Ultrasound sensitive agents for transcranial functional imaging, super-resolution microscopy and drug delivery." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC013.
Full textThis thesis focuses on two main branches of the application of ultrasound contrast agents: microbubbles-aided ultrafast ultrasound imaging of the brain and ultrasound-triggered drug delivery for cancer therapy. At first, gas-filled microbubbles have been used to retrieve the brain activation through the skull in large animais. With this approach we have been able to non-invasively reconstruct the cerebral network of the brain, as well as retrieve its hemodynamic response to specific evoked tasks with high spatiotemporal resolution. The validation of this novel functional ultrasound (fUS) imaging approach was facilitated by the high sensitivity of the ultrasensitive Doppler technique able to detect subtle hemodynamic changes due to the neurovascular coupling. These resuits suggested that combining microbubbles injections with ultrafast imaging may help to fully compensate for the attenuation from the skull. Indeed, by combining both, we preserved resolution and increased penetration depth. The injection of ultrasound contrast agents has also lead to outstanding resuits in ultrafast ultrasound imaging by breaking the diffraction barrier and move beyond the half-wavelength limit in resolution. We have demonstrated that cerebral microvessels of 9pm in diameter can me distinguished via ultrafast ultrasound localization microscopy (uULM). Millions of blinking sources were localized in space and in time in few seconds in a higher dimensional space, leading to super-resolved images (microbubble density map) of the whole rat brain with a spatial resolution of À/10. Moreover, a displacement vector allowed microbubbles-tracking within frames yielding to in-plane velocity measurements retrieving a large dynamic of cerebral blood velocities. Next, we have exploited how we can spatiotemporally control the vaporization of composite perfluorocarbon (PFC) microdroplets when their activation is triggered by short ultrasound pulses. The concept 'chemistry in-situ' is introduced as we have been able to control a spontaneous chemical reaction in-vitro. Moreover, a new microfluidic device in glass has been proposed to robustly produce monodisperse droplets for future in-vivo applications of the chemistry in situ. This new device presents 128-parallel generators with two pressurized rivers. Eventually, new ultrafast ultrasound monitoring sequences have been developed in order to control and monitor the release of composite droplets
Naik, Sweta. "Design of control release drug delivery system (DDS) for imaging and therapeutic applications." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2606.
Full textRose, Cornelia [Verfasser], and Achim [Akademischer Betreuer] Göpferich. "Particulate systems for fluorescence imaging and drug delivery / Cornelia Rose. Betreuer: Achim Göpferich." Regensburg : Universitätsbibliothek Regensburg, 2010. http://d-nb.info/1023312115/34.
Full textLi, Zhoulei. "Molecular imaging for characterization of lymphoma biology and monitoring response to cancer drug therapy." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-173181.
Full textGuduru, Rakesh. "In situ AFM Imaging of Nanoparticle- Cellular Membrane Interaction for a Drug Delivery Study." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/422.
Full textChoi, Sungmoon. "Fluorescent noble metal nanodots for biological applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37195.
Full textAsem, Heba. "Synthesis of Polymeric Nanocomposites for Drug Delivery and Bioimaging." Licentiate thesis, KTH, Funktionella material, FNM, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186300.
Full textQC 20160516
Khanna, Kunal. "Synthesis and self-assembly of miktoarm polymers and design of a drug-polymer-imaging conjugate." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92397.
Full textHolmes, Shannon. "Quantitative magnetic resonance imaging (MRI) assessment of hepatic responses to acute and chronic drug exposure." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0029/MQ47333.pdf.
Full textTsvetkova, Yoanna [Verfasser], Fabian [Akademischer Betreuer] Kießling, and Wolfgang [Akademischer Betreuer] Stahl. "Riboflavin-targeted nanomedicines for cancer imaging and drug delivery / Yoanna Tsvetkova ; Fabian Kießling, Wolfgang Stahl." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/118734625X/34.
Full textFurdella, Kenneth J., Russell S. Witte, and Geest Jonathan P. Vande. "Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy." SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 2017. http://hdl.handle.net/10150/624370.
Full textTayyabi, Ehsen. "Gone Fishing: Synthesis and Design of a Superparamagnetic Nanobait for Trapping Reactive Metabolites In Vivo." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37338.
Full textBobiak, John Peter. "Raman and Infrared Imaging of Dynamic Polymer Systems." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1133472157.
Full textDyke, Stephanie Odette Mary. "Investigating tumour response to the anti-vascular drug combretastatin A₄ using magnetic resonance imaging and spectroscopy." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598715.
Full textMurata, Yuki. "Design and Preparation of Gelatin-Based Carriers for Imaging Probes to Visualize Cell Functions." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263622.
Full textSolorio, Luis Jr. "Application of Ultrasound Imaging for Noninvasive Characterization of Phase Inverting Implants." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332258338.
Full textBlatherwick, Eleanor Q. "Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/57257/.
Full textKarakosta, Eleni. "Soluble drug release from a non-swelling polymer matrix studied by magnetic resonance and other imaging methods." Thesis, University of Surrey, 2006. http://epubs.surrey.ac.uk/844586/.
Full textStrindlund, Olle. "Evaluation of Homogeneity in Drug Seizures Using Near-Infrared (NIR) Hyperspectral Imaging and Principal Component Analysis (PCA)." Thesis, Linköpings universitet, Kemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166747.
Full textGriese, Florian [Verfasser]. "IVOCT catheter tracking and targeted drug delivery using magnetic particle imaging and magnetic particle navigation / Florian Griese." Hamburg : Universitätsbibliothek der Technischen Universität Hamburg-Harburg, 2020. http://d-nb.info/1224966627/34.
Full textRussell, Lisa Maria. "Dermatopharmacokinetics : an approach to evaluate topical drug bioavailability." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512306.
Full textBentz, Brian Z. "In Vivo Optical Imaging for Targeted Drug Kinetics and Localization for Oral Surgery and Super-Resolution, Facilitated by Printed Phantoms." Thesis, Purdue University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10274948.
Full textMany human cancer cell types over-express folate receptors, and this provides an opportunity to develop targeted anti-cancer drugs. For these drugs to be effective, their kinetics must be well understood in vivo and in deep tissue where tumors occur. We demonstrate a method for imaging these parameters by incorporating a kinetic compartment model and fluorescence into optical diffusion tomography (ODT). The kinetics were imaged in a live mouse, and found to be in agreement with previous in vitro studies, demonstrating the validity of the method and its feasibility as an effective tool in preclinical drug development studies.
Progress in developing optical imaging for biomedical applications requires customizable and often complex objects known as “phantoms” for testing and evaluation. We present new optical phantoms fabricated using inexpensive 3D printing methods with multiple materials, allowing for the placement of complex inhomogeneities in heterogeneous or anatomically realistic geometries, as opposed to previous phantoms which were limited to simple shapes formed by molds or machining. Furthermore, we show that Mie theory can be used to design the optical properties to match a target tissue. The phantom fabrication methods are versatile, can be applied to optical imaging methods besides diffusive imaging, and can be used in the calibration of live animal imaging data.
Applications of diffuse optical imaging in the operating theater have been limited in part due to computational burden. We present an approach for the fast localization of arteries in the roof of the mouth that has the potential to reduce complications. Furthermore, we use the extracted position information to fabricate a custom surgical guide using 3D printing that could protect the arteries during surgery.
The resolution of ODT is severely limited by the attenuation of high spatial frequencies. We present a super-resolution method achieved through the point localization of fluorescent inhomogeneities in a tissue-like scattering medium, and examine the localization uncertainty numerically and experimentally. Furthermore, we show numerical results for the localization of multiple fluorescent inhomogeneities by distinguishing them based on temporal characteristics. Potential applications include imaging neuron activation in the brain.
Kampmeier, Florian [Verfasser]. "Site directed modification of recombinant antibody fragments for in vivo fluorescence imaging and targeted drug delivery / Florian Kampmeier." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1014263816/34.
Full textFoy, Susan Patricia. "Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040.
Full textThovhogi, Ntevheleni. "Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model." University of the Western Cape, 2013. http://hdl.handle.net/11394/4753.
Full textObesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. Therefore, a need still exists for the development of safe medication for treatment of obesity. Nanotechnology involves the use of small particles at atomic and molecular scale. It has application in medical diagnostics, drug delivery and molecular imaging. Various nanoparticles (NPs) functionalized with different biomolecules have been successfully used in many therapeutic and research applications due to their versatility, ease of chemical synthesis, low toxicity and unique properties. Examples of NPs used in this study are Gold nanoparticles (GNPs) and Quantum dots (QDs). GNPs and QDs are extensively used as drug delivery, labelling and imaging tools in biomedical research. Nanotechnology offers a new potential useful avenue for solving the problem of toxicity of anti-obesity drugs. This could be achieved through targeted drug delivery. In this study, rats were fed a high fed diet (HFD) to induce obesity. The streptavidin conjugated GNPs and QDs were functionalized with biotinylated adipose-homingpeptide (AHP) and/or anti-obesity drug (Gallic acid). Functionalization was characterized using agarose gel electrophoresis, UV-vis spectroscopy and transmission electron microscopy. The binding-specificity and targeting ability of AHP was evaluated in vitro and in vivo. The apoptotic effect of AHP functionalized-drug loaded GNPs (AHP-GA-GNPs) was tested in vitro using APOPercentage TM and Caspase-3 activation assays. The in vitro data indicated that the binding was specific to prohibitin (PHB) expressing cells (MCF-7 and Caco-2), and that the binding was temperature dependent. PHB was confirmed as a target for AHP after overlaying AHP-FITC and anti-prohibitin antibody staining. Cellular uptake was detected on the cells treated with AHP-functionalized NPs as compared to unfunctionalized NPs. The GA and AHP-GA-GNPs reduced cellular viability and induced apoptosis through activation of Caspase-3. The Ex-vivo studies using primary endothelial cells (ECs) isolated from the WAT of lean and obese Wistar rats showed that the binding of AHP was receptor mediated, and specific to receptors differentially expressed in ECs from obese WAT. The in vivo studies showed that, treatment of obese rats with AHP-functionalized NPs resulted in targeted delivery of the NPs to the WAT as compared to those treated with unfunctionalized NPs. Qualitative analysis using fluorescence microscopy and IVIS Luminar XR, live-imaging system showed that the unfunctionalized NPs accumulated mostly in the organs of the reticuloendothelial system, namely: liver, spleen, lungs and kidneys. In contrast, AHP-functionalized NPs accumulated mostly in the WATs as compared to the rest of the organs of the obese rats. Uptake and binding of the NPs to the tissues was quantitatively confirmed by the inductive coupled plasma-optical emission spectroscopy (ICP-OES). In conclusion, this study reports the 1) successful functionalization of GNPs and QDs with AHP, 2) use of AHP-functionalized GNPs and QDs as delivery and imaging agents to the WAT, and 3) potential use of AHP-functionalized drug-loaded GNPs in the treatment of obesity.
Li, Zhoulei [Verfasser], and Christine [Akademischer Betreuer] Spitzweg. "Molecular imaging for characterization of lymphoma biology and monitoring response to cancer drug therapy / Zhoulei Li. Betreuer: Christine Spitzweg." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1055907866/34.
Full textCho, Hoon-Sung. "Design and Development of a multifunctional nano carrier system for imaging, drug delivery, and cell targeting in cancer research." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275936260.
Full textMiyake, Yuka. "Synthesis and Functional Evaluation of Novel Chiral Dendrimer-triamine-coordinated Gd-MRI Contrast Agents That Can Act as Molecular Probes." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215564.
Full textNagura, Kota. "Development of All-Organic Magnetic Mixed Micelles Aiming at Biomedical Application." Kyoto University, 2019. http://hdl.handle.net/2433/242750.
Full text0048
新制・課程博士
博士(人間・環境学)
甲第21873号
人博第902号
新制||人||215(附属図書館)
2018||人博||902(吉田南総合図書館)
京都大学大学院人間・環境学研究科相関環境学専攻
(主査)教授 小松 直樹, 教授 加藤 立久, 准教授 廣戸 聡
学位規則第4条第1項該当
Wischhusen, Jennifer. "Ultrasound Microbubbles for Molecular Imaging and Drug Delivery : detection of Netrin-1 in Breast Cancer & Immunomodulation in Hepatocellular Carcinoma." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1317/document.
Full textUltrasound molecular imaging uses microbubbles as ultrasound contrast agents which are functionalized with targeting ligands. Upon intravenous injection, targeted microbubbles bind to molecular markers presented on the tumor endothelium and enable the non-invasive assessment cancer-related biomarkers. In the present thesis, ultrasound molecular imaging was developed for detection of netrin-1, which is upregulated in 70% of metastatic breast cancer and promotes cell survival. A newly developed netrin-1 interference therapy requires the identification of patients who overexpress the target protein and, could benefit from anti-netrin-1 therapy. In vivo imaging of netrin-1 showed a significantly increased imaging signal in netrin-1-positive breast tumors compared to netrin-1-negative breast tumors and normal mammary glands. The results suggest that ultrasound molecular imaging allows accurate detection of netrin-1 on the endothelium of netrin-1-positive tumors and has the potential to become a companion diagnostic for netrin-1 interference therapy in breast cancer patients.Ultrasound-targeted microbubble destruction triggers cavitation and sonoporation thereby permeabilizing the tissue and facilitating local drug delivery. Further, immune cell infiltration and tumor antigen release are induced and trigger anti-tumor immune responses. In the present thesis, ultrasound-targeted microbubble destruction-mediated delivery of anti-cancer microRNA-122 and anti-microRNA-21 is studied for immune response activation in hepatocellular carcinoma, in which the immune microenvironment is deregulated. Tumor lymph nodes showed pro-tumor cytokine downregulation and anti-tumor cytokine upregulation, suggesting an overall positive therapy response with regard to the tumor immunology. The results identified ultrasound-targeted microbubble destruction-mediated miRNA delivery as a potent immuno-modulatory therapeutic approach