Relevant bibliographies by topics / Drug imaging

Academic literature on the topic 'Drug imaging'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Drug imaging"

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T. Varkey, Jaya. "Peptides-Incorporated Nanoparticles for Imaging and Drug Delivery Applications." Journal of Pharmaceutical and Medicinal Chemistry 2, no. 2 (2016): 145–48. http://dx.doi.org/10.21088/jpmc.2395.6615.2216.4.

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Malhotra, Rhea, and Ajay Singh. "Imaging of drug mules." Emergency Radiology 28, no. 4 (March 18, 2021): 809–14. http://dx.doi.org/10.1007/s10140-021-01924-3.

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Kitson, Sean. "Squaryl Molecular Metaphors – Application to Rational Drug Design and Imaging Agents." Journal of Diagnostic Imaging in Therapy 4, no. 1 (May 3, 2017): 35–75. http://dx.doi.org/10.17229/jdit.2017-0503-029.

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Koshikawa, N., A. Omata, M. Masubuchi, Y. Okazaki, J. Kataoka, K. Matsunaga, H. Kato, A. Toyoshima, Y. Wakabayashi, and T. Kobayashi. "Activation imaging of drugs with hybrid Compton camera: A proof-of-concept study." Applied Physics Letters 121, no. 19 (November 7, 2022): 193701. http://dx.doi.org/10.1063/5.0116570.

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The visualization of drugs is essential for cancer treatment. Although several methods for visualizing drugs have been proposed, a versatile method that can be easily applied to various drugs has not yet been established. Therefore, we propose “activation imaging,” in which a drug is irradiated with thermal neutrons and becomes radioactive, enabling visualization using emitted x rays and/or gamma rays. Activation imaging does not require the conjugation of specific tracers with drugs. Therefore, it can be easily applied to a variety of drugs, drug carriers (e.g., metal nanoparticles), and contrast agents. In this study, neutron activation, gamma-ray spectroscopy, and imaging of drug carriers, anticancer drug, and contrast agents were performed. Gold nanoparticles (AuNPs) and platinum nanoparticles were used as drug carriers, cisplatin was used as an anticancer drug, and gadoteridol and iohexol were used as contrast agents. As a neutron source, the RIKEN accelerator-driven compact neutron source II (RANS-II) was utilized. The imaging was performed using a hybrid Compton camera (HCC). The HCC can visualize x rays and gamma rays ranging from a few keV to nearly 1 MeV, which enables the imaging of various x rays and gamma rays emitted from the activated drugs. As a result, the gamma-ray spectra indicated the generation of radioisotopes through neutron irradiation, and AuNPs and iohexol were visualized.
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Ban, Weikang, Yuyang You, and Zhihong Yang. "Imaging Technologies for Cerebral Pharmacokinetic Studies: Progress and Perspectives." Biomedicines 10, no. 10 (September 30, 2022): 2447. http://dx.doi.org/10.3390/biomedicines10102447.

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Pharmacokinetic assessment of drug disposition processes in vivo is critical in predicting pharmacodynamics and toxicology to reduce the risk of inappropriate drug development. The blood–brain barrier (BBB), a special physiological structure in brain tissue, hinders the entry of targeted drugs into the central nervous system (CNS), making the drug concentrations in target tissue correlate poorly with the blood drug concentrations. Additionally, once non-CNS drugs act directly on the fragile and important brain tissue, they may produce extra-therapeutic effects that may impair CNS function. Thus, an intracerebral pharmacokinetic study was developed to reflect the disposition and course of action of drugs following intracerebral absorption. Through an increasing understanding of the fine structure in the brain and the rapid development of analytical techniques, cerebral pharmacokinetic techniques have developed into non-invasive imaging techniques. Through non-invasive imaging techniques, molecules can be tracked and visualized in the entire BBB, visualizing how they enter the BBB, allowing quantitative tools to be combined with the imaging system to derive reliable pharmacokinetic profiles. The advent of imaging-based pharmacokinetic techniques in the brain has made the field of intracerebral pharmacokinetics more complete and reliable, paving the way for elucidating the dynamics of drug action in the brain and predicting its course. The paper reviews the development and application of imaging technologies for cerebral pharmacokinetic study, represented by optical imaging, radiographic autoradiography, radionuclide imaging and mass spectrometry imaging, and objectively evaluates the advantages and limitations of these methods for predicting the pharmacodynamic and toxic effects of drugs in brain tissues.
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Jaklevic, Mary Chris. "Imaging Drug for Prostate Cancer." JAMA 325, no. 3 (January 19, 2021): 214. http://dx.doi.org/10.1001/jama.2020.26384.

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Perkins, Alan, and Malcolm Frier. "Radionuclide Imaging in Drug Development." Current Pharmaceutical Design 10, no. 24 (September 1, 2004): 2907–21. http://dx.doi.org/10.2174/1381612043383476.

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Nicholls, Stephen J., Srinivasa Kalidindi, Keon-Woong Moon, and Steven E. Nissen. "Atherosclerosis imaging in drug development." Expert Opinion on Drug Discovery 2, no. 9 (August 29, 2007): 1241–50. http://dx.doi.org/10.1517/17460441.2.9.1241.

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Baleato-Gonzalez, Sandra, Roberto Garcia-Figueiras, Maria Casais, Amadeo Diaz, Ivan Sanz-Falque, and Joan Vilanova. "Imaging in Drug Side Effects." Current Medical Imaging Reviews 11, no. 1 (April 23, 2015): 23–37. http://dx.doi.org/10.2174/157340561101150423104805.

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Lang, Paul, Karen Yeow, Anthony Nichols, and Alexander Scheer. "Cellular imaging in drug discovery." Nature Reviews Drug Discovery 5, no. 4 (April 2006): 343–56. http://dx.doi.org/10.1038/nrd2008.

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Dissertations / Theses on the topic "Drug imaging"

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Blazek, Almira. "NMR imaging investigations of swelling-controlled drug delivery." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34513.pdf.

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Trim, Paul James. "MALDI-MS imaging for direct drug distribution analysis." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20455/.

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MALDI Imaging has gained huge interest in the past few years with an ever increasing population of specialists choosing to investigate samples using MALDI imaging, including growing interest and financial backing from pharma and contract research organisations. Presented within this thesis is the development and application of MALDI imaging techniques for a variety of analytical problems. The use of various software packages have been employed in the interpretation of the data acquired from MALDI experiments including, the use of statistical analysis for the identification of ion of interest from 6 distinct brain regions and also for the identification of ions of interest associated with small molecule tumour markers. The advantages of MALDI-IMS-MSI as a further separation stage within MALDI-MSI have been shown. Demonstrated is a method for MALDI-IMS-MS imaging of endogenous lipids in healthy tissue and tumours, also demonstrated is the application of MALDI-IMS-MS to xenobiotic distribution studies, it has been clearly shown that ion mobility separation within MALDI-MSI experiments can improve the analysis of xenobiotics by removing any interfering ions. With instrumentation development for MALDI a high repetition rate Nd:YVO4 laser has been assessed as a possible method for decreasing acquisition time.
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Chen, Chen. "Quantitative magnetic resonance imaging studies of extended drug release systems." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708155.

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Gade, Terence Peter Ferrante. "Integrated imaging of drug delivery : a molecular imaging approach to the optimization of cancer therapy /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1432803381&sid=12&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Sauer, Anna Magdalena. "Live-cell imaging of drug delivery by mesoporous silica nanoparticles." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138222.

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Septiadi, Dedy. "Optical imaging and drug delivery using soft- and hard- nanomaterials." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF036/document.

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Le travail décrit dans cette thèse se concentre sur le développement de matériaux « durs et mous » ainsi que leur interaction avec les cellules biologiques pour une application finale dans le domaine de la théranostique couvrant l'imagerie, la détection, la thérapie génique et la thérapie du cancer. Dans ce contexte, nous avons tout d'abord étudié l'utilisation de complexes (II) de platine phosphorescents auto-assemblés comme sonde cellulaire. Nous avons étendu l'idée de bio-imagerie en introduisant un concept d’imagerie basée sur l’émission stimulée où nous étions en mesure de générer un laser provenant d'une cellule biologique unique sans utiliser de cavité optique conventionnelle. En outre, des nano-transporteurs multifonctionnels à base de matières poreuses dures à savoir des zéolithes L et des nanoparticules de silice mésoporeuse pour de la « drug delivery » (relargage de médicaments et d’oligonucléotides) in vitro ide ont été développés avec succès et testés pour le traitement du glioblastome. Un autre nano-vecteur, qui est construit à partir de silice biodégradable, a également été synthétisé et sa capacité d'encapsuler des protéines et de les libérer dans les cellules vivantes lors de la dégradation de la structure dans un environnement réducteur a été démontrée. Enfin, l'utilisation de nouveaux matériaux plasmonique sur la base de nanoparticules d'argent enrobées de silice cassable pour la détection d'agents réducteurs a été mise en valeur
The work described in this thesis focuses on the development of soft- and hard-materials as well as their interaction with biological cells for applications in the field of theranostics covering imaging, sensing, and gene, and cancer therapy. In this context, we first investigated the use of phosphorescent self-assembled platinum(II) complexes as cellular probes. We extended the concept stimulated emission-based bioimaging by generating a laser-like emission coming from a single biological cell without using any conventional optical cavity. In addition, we successfully developed multifunctional nanocarriers based on porous hard materials, namely zeolites-L and mesoporous silica nanoparticles for drug and oligonucleotide delivery in vitro and they were tested to treat glioblastoma. Another nanovector, which is constructed from biodegradable silica, was also synthesized and its ability to encapsulate proteins and release them in living cells upon degradation of the structure in reductive environment was demonstrated. Finally, the use of novel plasmonic structures based on breakable silica-coated silver nanoparticles for detection of reducing agents was successfully investigated
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Tang, Jingjie. "Innovative imaging systems and novel drug candidates for cancer therapy." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4021.

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Le cancer est l'une des principales causes de décès dans le monde et reste une maladie difficile à traiter du fait des difficultés de pronostic, du développement rapide de métastases et de la résistance aux médicaments. Il en résulte une forte demande en méthodologies d'imagerie innovantes pour le diagnostic précoce et précis ainsi qu’en nouveaux agents anticancéreux possédant de nouveaux mécanismes pour surmonter la résistance aux médicaments. Le but de mon projet de recherche de doctorat était donc de contribuer à cet objectif.La première partie de ma thèse de doctorat a porté sur la création de systèmes sensibles et précis d'imagerie pour la détection de tumeurs cancéreuses en utilisant une nanotechnologie novatrice permettant la délivrance des agents d'imagerie spécifiquement dans les lésions tumorales. Nous avons conçu de nouveaux dendrimères amphiphiles pour assurer le transport de différents agents d'imagerie pour les imageries PET/SPECT, par résonance magnétique et par fluorescence optique. Ces systèmes d'imagerie ont été préparés soit par encapsulation de petites sondes d'imagerie à l'intérieur de nanomicelles dendritiques ou par fonctionnalisation de la surface hydrophile ou de la queue hydrophobe du dendrimère. La deuxième partie a eu pour objectif de développer de nouveaux agents anticancéreux possédant nouveaux mécanismes d’action et une meilleure activité antitumorale. A cet effet, nous avons conçu une série de nucléosides arylvinyltriazoles par réaction oxydante de Heck, ce qui nous a permis d'obtenir les composés désirés pourtant difficiles à synthétiser avec un très large éventail de substrats et une stéréosélectivité unique
Cancer is one of the leading causes of death in the world, and remains a difficult disease to treat because of poor prognosis, rapid tumor metastasis and drug resistance. Therefore, innovative imaging modalities for early and precise diagnosis as well as new anticancer drug candidates with novel mechanisms to overcome drug resistance are in high demand. The aim of my PhD research project was to contribute to this goal.The first part of my PhD thesis was focused on establishing sensitive and precise imaging systems for cancer detection using innovative nanotechnology to deliver imaging agents specifically into tumor lesions. We designed and constructed novel amphiphilic dendrimers to carry different imaging agents for PET/SPECT imaging, magnetic resonance imaging and optical fluorescence imaging. These innovative imaging systems were prepared by either encapsulation of small imaging probes within the dendrimer nanomicelles, or functionalization of the dendrimer hydrophilic surface or hydrophobic tail. The second part of my PhD program aimed to develop new anticancer drug candidates with novel mechanisms for better anticancer activity. Therefore, we designed and synthesized a series of challenging arylvinyltriazole nucleosides via the oxidative Heck reaction, which allowed us to obtain the desired compounds with excellent substrate scope and unique stereoselectivity
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Varela, Aramburu Silvia [Verfasser]. "Carbohydrate-based Nanomaterials for Imaging and Drug Delivery / Silvia Varela Aramburu." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/117663254X/34.

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Ewing, Andrew. "ATR-FTIR spectroscopic imaging to study drug release and tablet dissolution." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/51556.

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The active pharmaceutical ingredient (API) and excipients are vital for determining the behaviour of drug release from tablet compacts. Macro attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging can be employed for in situ studies of dissolving tablets. This thesis describes new developments that applied macro ATR-FTIR spectroscopic imaging to investigate the stability and dissolution of amorphous APIs, the effect of carriers for improving drug release, the stability of ionised drug candidates and the behaviour of multiple formulations in microfluidic devices. Solid dispersions containing an amorphous drug formulated with different polymers were investigated using ATR-FTIR spectroscopy and spectroscopic imaging. Crystallisation of the amorphous drug was detected during stability and tablet dissolution experiments. The implications of this form change inhibited dissolution of the drug into solution. ATR-FTIR spectroscopic imaging was also used in combination with ultraviolet detection to study the release of a drug formulated with selected carriers. Hydrogen bonded interactions between the drug and carrier were characterised and resulted in an increased rate of drug release. When these interactions were not present in the tablet, a slower rate of dissolution was observed. Disproportionation of an ionised drug was investigated by ATR-FTIR spectroscopic imaging and Raman mapping. During dissolution experiments in acidic solution, chemical changes of the ionised API were detected in real time that resulted in the formation of the less soluble form of the drug. Exciting results were obtained by simultaneously screening the behaviour of multiple formulations in microfluidic channels using macro ATR-FTIR spectroscopic imaging. Moreover, the precipitation of a dissolved drug that crystallised upon contact with an acidic solution was investigated. Overall, the research in this thesis has demonstrated that macro ATR-FTIR spectroscopic imaging can address the challenges of studying a range of innovative delivery systems that can ultimately lead to the development of more efficient pharmaceutical formulations.
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Zhang, Rui. "Ionic Copolymer-Magnetite Complexes for Magnetic Resonance Imaging and Drug Delivery." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73648.

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This thesis is focused on the design, synthesis and characterization of magnetite-ionic copolymer complexes as nanocarriers for drug delivery and magnetic resonance imaging. The polymers included phosphonate and carboxylate-containing graft and block copolymers. Oleic-acid coated magnetite nanoparticles (8-nm and 16-nm diameters) were investigated. Cisplatin and carboplatin were used as sample drugs. The potentials of the magnetite-ionomer complexes as dual drug delivery carriers and magnetic resonance imaging agents were evaluated. An acrylate-functional poly(ethylene oxide) macromonomer and hexyl (and propyl) ammonium bisphosphonate methacrylate monomers were synthesized. Conventional free radical copolymerizations were conducted to synthesize the graft copolymers. The acrylate-functional poly(ethylene oxide) macromonomer was also used to form graft copolymers with tert-butyl acrylate. Block ionomers containing poly(tert-butyl acrylate) were synthesized via atom transfer radical polymerization, then the tert-butyl groups were removed to afford anions. All the monomers and polymers were characterized by 1H NMR to confirm their structures and assess their compositions. Phosphonate-containing polymers were also characterized by 31P NMR. Magnetite nanoparticles (8-nm diameter) were synthesized by reducing Fe(acac)3 with benzyl alcohol. The 16-nm diameter magnetite was synthesized by thermal decomposition of an iron oleate precursor in trioctylamine as a high-boiling solvent. The iron-oleate precursor was synthesized with iron (III) chloride hexahydrate and sodium oleate with mixed solvents. TEM images of the magnetite were obtained. Magnetite-ionomer complexes were synthesized by binding a portion of the anions (carboxylate or phosphonate) on the copolymers onto the surfaces the magnetite. The remainder of the anions was used to bind with cisplatin and carboplatin via chelation. Physicochemical properties of the complexes were measured by dynamic light scattering. All the complexes with different polymers and magnetite nanoparticles displayed relatively uniform sizes and good size distributions. The magnetite-ionomer complexes displayed good colloidal stabilities in simulated physiological conditions for at least 24 hours. Those graft and block copolymer-magnetite complexes may be good candidates as drug carriers for delivery applications. After cisplatin and carboplatin loading, the sizes of the complexes increased slightly and the zeta potential decreased slightly, which indicated that the loadings were successful. Minimal loss of iron was found, signaling that the binding strengths between the magnetite and the anions of the graft copolymers were strong. 8.7 wt% of platinum was found in the cisplatin loaded complexes and 6.9% in the carboplatin loaded complexes. The results indicated that the magnetite-graft ionomer complexes were capable of loading drugs. Drug release studies were performed at pH 4.6 and 7.4 to mimick endosomal conditions and the physiological environment. Sustained release of drugs was observed. This further indicated the potential for using the magnetite-ionomer complexes as drug carriers. Transverse relaxivities of the magnetite-ionomer complexes with and without drugs were measured and compared to a commercial T2-weighted iron MRI contrast agent-Feridex®. All the complexes had higher relaxivities compared to Feridex®. Thus, the magnetite-ionomer complexes are promising candidates for dual magnetic resonance imaging and drug delivery.Moreover, the aqueous dispersion of the complexes was found to heat upon exposure to an AC magnetic field, thus potentially allowing heat-induced drug release.
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Books on the topic "Drug imaging"

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G, Ansell, and Ansell G, eds. Imaging drug reactions and toxic hazards. 3rd ed. London: Chapman & Hall Medical, 1997.

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Li, Chun, and Mei Tian, eds. Drug Delivery Applications of Noninvasive Imaging. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.

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P, Peppers Michael, ed. Pharmacology and drug administration for imaging technologists. 2nd ed. St. Louis: Mosby/Elsevier, 2006.

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Moyer, Brian R., Narayan P. S. Cheruvu, and Tom C. C. Hu, eds. Pharmaco-Imaging in Drug and Biologics Development. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-8247-5.

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Borsook, David, Lino R. Beccera, Edward Bullmore, and Richard J. Hargreaves, eds. Imaging in CNS Drug Discovery and Development. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0134-7.

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Atul, Tiwari, ed. Nanomaterials in drug delivery, imaging, and tissue engineering. Hoboken, New Jersey: John Wiley & Sons, 2013.

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Tiwari, Ashutosh, and Atul Tiwari, eds. Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118644591.

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Herrling, Paul L., Alex Matter, and Markus Rudin, eds. Imaging in Drug Discovery and Early Clinical Trials. Basel: Birkhäuser Basel, 2005. http://dx.doi.org/10.1007/3-7643-7426-8.

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Burns, H. Donald, Raymond E. Gibson, Robert F. Dannals, and Peter K. S. Siegl, eds. Nuclear Imaging in Drug Discovery, Development, and Approval. Boston, MA: Birkhäuser Boston, 1993. http://dx.doi.org/10.1007/978-1-4684-6808-3.

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Tamaki, Nagara, and Yuji Kuge, eds. Molecular Imaging for Integrated Medical Therapy and Drug Development. Tokyo: Springer Japan, 2010. http://dx.doi.org/10.1007/978-4-431-98074-2.

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Book chapters on the topic "Drug imaging"

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Hauff, Peter, and Klaus Nebendahl. "Drug Administration." In Small Animal Imaging, 127–52. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-42202-2_8.

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Nebendahl, Klaus, and Peter Hauff. "Drug Administration." In Small Animal Imaging, 93–116. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-12945-2_8.

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Artemov, Dmitri, and Zaver M. Bhujwalla. "Novel Imaging Agents for Molecular MR Imaging of Cancer." In Drug Discovery Handbook, 1309–41. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471728780.ch28.

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Peters, Sören, and Rudolf Andre Kley. "Toxic and Drug-Induced Myopathies." In Neuromuscular Imaging, 335–48. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6552-2_27.

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Newman, Stephen P. "IMAGING PULMONARY DRUG DELIVERY." In Drug Delivery Applications of Noninvasive Imaging, 333–66. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.ch15.

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Kuehl, Philip J. "Imaging Pulmonary Drug Delivery." In Controlled Pulmonary Drug Delivery, 475–87. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-9745-6_20.

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Kurdziel, Karen A., Esther Mena, Stephen Adler, and Peter Choyke. "Imaging in Drug Development." In Cancer Drug Discovery and Development, 731–46. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9135-4_36.

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Popolizio, Teresa, Maria Teresa Cascavilla, Nicola Sforza, Antonio Casillo, and Alessandra Stranieri. "Drug-induced Leukoencephalopathy." In Imaging Gliomas After Treatment, 191. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2370-3_53.

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Popolizio, Teresa, Maria Teresa Cascavilla, Nicola Sforza, Antonio Casillo, and Alessandra Stranieri. "Drug-induced Leukoencephalopathy." In Imaging Gliomas After Treatment, 193. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2370-3_54.

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Popolizio, Teresa, Maria Teresa Cascavilla, Nicola Sforza, Antonio Casillo, and Alessandra Stranieri. "Drug-induced Thrombosis." In Imaging Gliomas After Treatment, 195. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2370-3_55.

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Conference papers on the topic "Drug imaging"

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Wei, Lu. "Chemical imaging for Biomedicine." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2019. http://dx.doi.org/10.1364/omp.2019.ot3d.3.

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Zvyagin, Andrei V., Varun K. Sreenivasan, Timothy A. Kelf, and Sergey M. Deyev. "Luminescent Nanodiamonds for Intracellular Imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/omp.2011.omd1.

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Jelinek, Raz, and Sukhendu Nandi. "Carbon dots for biological imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/omp.2015.om4d.1.

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Meng, Boyu, Brook K. Byrd, Dennis J. Wirth, Rendall R. Strawbridge, and Scott C. Davis. "Developing a novel hyperspectral imaging cryomacrotome for whole body fluorescence imaging." In Visualizing and Quantifying Drug Distribution in Tissue IV, edited by Conor L. Evans and Kin Foong Chan. SPIE, 2020. http://dx.doi.org/10.1117/12.2544497.

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West, Jennifer. "Optically-controlled Drug Delivery." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/omp.2015.om3d.1.

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Windbergs, Maike. "Hyperspectral imaging of drug delivery." In 2017 Conference on Lasers and Electro-Optics Europe (CLEO/Europe) & European Quantum Electronics Conference (EQEC). IEEE, 2017. http://dx.doi.org/10.1109/cleoe-eqec.2017.8087192.

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Bower, Andrew J., Joanne Li, Eric J. Chaney, Marina Marjanovic, and Stephen A. Boppart. "High-Speed Two-Photon Fluorescence Lifetime Imaging Microscopy of NADH for Label-Free Metabolic Imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2017. http://dx.doi.org/10.1364/omp.2017.oms2d.5.

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Akers, Walter J., Mikhail Berezin, Hyeran Lee, and Samuel Achilefu. "Fluorescence Lifetime in Optical Molecular Imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/omp.2011.otuc1.

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Attia, Amalina Binte Ebrahim, Chris Jun Hui Ho, Prashant Chandrasekharan, Ghayathri Balasundaram, Kai-Hsiang Chuang, and Malini Olivo. "Molecular Photoacoustic Imaging of Orthotopic Glioblastoma." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/omp.2015.ow3d.3.

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Pena, Ana-Maria, Luc Aguilar, Gayané Azadiguian, Thérèse Baldeweck, Ludwig Baux, Annie Black, Thomas Bornschlögl, et al. "Multiphoton imaging in cosmetics research." In Visualizing and Quantifying Drug Distribution in Tissue III, edited by Conor L. Evans and Kin Foong Chan. SPIE, 2019. http://dx.doi.org/10.1117/12.2508902.

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Reports on the topic "Drug imaging"

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Wang, Yanming. InVivo Imaging of Myelination for Drug Discovery and Development in Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada580016.

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McFadden, Ian. Folate-Targeted Proteolytic Macromolecules for Targeted Drug Delivery and Optical Tumor Imaging. Fort Belvoir, VA: Defense Technical Information Center, February 2011. http://dx.doi.org/10.21236/ada552633.

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada439254.

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Zarabi, Bahar, and Hamid Ghandehari. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, July 2006. http://dx.doi.org/10.21236/ada469974.

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Zarabi, Bahar. Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors. Fort Belvoir, VA: Defense Technical Information Center, December 2007. http://dx.doi.org/10.21236/ada480781.

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Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, October 2021. http://dx.doi.org/10.25148/mmeurs.009774.

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Cervical cancer is one of the most common causes of cancer death for women in the United States. The current treatment with chemotherapy drugs has significant side effects and may cause harm to healthy cells rather than cancer cells. In order to combat the potential side effects, nanoparticles composed of mesoporous silica were created to house the chemotherapy drug doxorubicin (DOX). The silica network contains the drug, and a pH study was conducted to determine the conditions for the nanoparticle to disperse the drug. The introduction of disulfide bonds within the nanoparticle created a framework to efficiently release 97% of DOX in acidic environments and 40% release in neutral environments. The denotation of acidic versus neutral environments was important as cancer cells are typically acidic. The chemistry was proved with the incubation of the loaded nanoparticle into HeLa cells for a cytotoxicity report and confocal imaging. The use of the framework for the anticancer drug was shown to be effective for the killing of cancerous cells.
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Mullens, J. A., P. A. Hausladen, D. E. Archer, M. C. Wright, and J. T. Mihalczo. NMIS With Imaging and Gamma Ray Spectrometry for PU, HEU, HE, Chemical Agents and Drugs. Office of Scientific and Technical Information (OSTI), July 2007. http://dx.doi.org/10.2172/1484364.

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Xin, Yuning, Hongyu Li, Gungyu Cheng, Junfeng Cui, Yinghui Liu, Aidong Liu, Xiaolin Xu, Pengfei Li, and Huize Han. Evaluation of the Effectiveness and Safety of Acupuncture in the Treatment of Cervicogenic Hypertension A Protocol for Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0036.

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Review question / Objective: The purpose of this study is to explore the efficacy and safety of acupuncture in the treatment of patients with cervicogenic hypertension，Through scientific verification, it provides clinicians with application reference and provides more choices for patients to solve pain. Patients included should have a clear diagnosis of cervicogenic hypertension(In the absence of antihypertensive drugs, blood pressure was measured 3 times a day, systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg; or a clear history of hypertension and Diagnosis of cervical spondylosis using computed tomography, magnetic resonance imaging, and other imaging methods)；The intervention group received acupuncture treatment alone or acupuncture combined with treatment by Chinese herbal medicine or conventional Western medicine; The control group was a blank control group, a placebo group, a fake acupuncture group or received treatment only through conventional Western medicine； The Inclusion criteria of study type was an RCT; The outcomes of the main analyses were efficacy of clinical symptoms，systolic blood pressure value，Diastolic blood pressure value；Secondary outcome indicators were Traditional Chinese Medicine syndrome curative effects, Traditional Chinese Medicine syndrome scores,and adverse reactions.
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Li, Xiao, GX Xu, FY Ling, ZH Yin, Y. Wei,, Y. Zhao, Xn Li, WC Qi, L. Zhao, and FR Liang. The dose-effect association between electroacupuncture sessions and its effect on chronic migraine: a protocol of a meta-regression of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0085.

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Review question / Objective: We will use a meta-regression approach to verify the dose-effect relationship between the number of electroacupuncture sessions and its effects on migraine. Condition being studied: Migraine is recurrent and chronic, requiring long-term control, but the side effects caused by long-term use limit the use of pharmacotherapy, like non-steroidal anti-inflammatory drugs (NSAIDS), ergoamines and opioids. With fewer side effects and lower cost, acupuncture is becoming a more attractive option for migraine. Relevant studies have confirmed the clinical effects of electroacupuncture on migraine and its effects on intracranial blood flow velocity, functional brain imaging and neuroinflammation. However, uncertainty exists regarding the dose-effect between electroacupuncture and migraine. In recent years, inspired by the dose-effect researches in pharmacology and epidemiology, researches focusing on the dose-effect association between acupuncture and diseases has also begun to emerge. So in this protocol, we designed to use a meta-regression approach to explore the optimal electroacupuncture dose for migraine.
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Asenath-Smith, Emily, Ross Lieblappen, Susan Taylor, Reed Winter, Terry Melendy, Robert Moser, and Robert Haehnel. Observation of crack arrest in ice by high aspect ratio particles during uniaxial compression. Engineer Research and Development Center (U.S.), February 2022. http://dx.doi.org/10.21079/11681/43145.

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In nature, ice frequently contains dissolved solutes or entrapped particles, which modify the microstructure and mechanical properties of ice. Seeking to understand the effect of particle shape and geometry on the mechanical properties of ice, we performed experiments on ice containing 15 wt% silica spheres or rods. Unique to this work was the use of 3-D microstructural imaging in a -10ºC cold room during compressive loading of the sample. The silica particles were present in the ice microstructure as randomly dispersed aggregates within grains and at grain boundaries. While cracks originated in particle-free regions in both sphere- and rod-containing samples, the propagation of cracks was quite different in each type of sample. Cracks propagated uninhibited through aggregates of spherical particles but were observed to arrest at and propagate around aggregates of rods. These results imply that spherical particles do not inhibit grain boundary sliding or increase viscous drag. On the other hand, silica rods were found to span grains, thereby pinning together the microstructure of ice during loading. These results provide insights into mechanisms that can be leveraged to strengthen ice.
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