Log in

Relevant bibliographies by topics / Drug effects / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Drug effects.

Dissertations / Theses on the topic 'Drug effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Drug effects.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Cong, Ze. "Value of pharmaceutical innovation the access effects, diffusion process, and health effects of new drugs /." Santa Monica: RAND, 2009. http://www.rand.org/pubs/rgs_dissertations/2009/RAND_RGSD242.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Näsman, Margareta. "Effects of anti-neoplastic therapy on tooth and bone formation : clinical and experimental studies /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3282-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Gao, Xiang. "Kinetics of drug disposition and effects /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942739808919.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kim, Chang Kwon. "The role of the drug-effect contingency in the development of cross tolerence to anticonvulsant drug effects." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28249.

Full text

Abstract:

It was recently demonstrated that tolerance develops to the anticonvulsant effect of ethanol on kindled convulsions elicited in rats by electrical stimulation of the amygdala, following each of a series of ethanol injections delivered on a bidaily schedule (once every 48 hr). The tolerance developed only when the convulsive stimulation was administered during the periods of ethanol exposure: subjects that received ethanol 1.5 hr before each convulsive stimulation demonstrated tolerance after just five ethanol injections; whereas, no tolerance was evident in subjects that received ethanol 1.5 hr after each stimulation. Such tolerance, which is not the inevitable product of drug exposure but is contingent upon the expression of the drug effect--the anticonvulsant effect in this case--has been termed contingent tolerance. In Experiment 1A, tolerance developed to the anticonvulsant effects of bidaily IP injections of phenobarbital (30 mg/kg), trimethadione (270 mg/kg) and clonazepam (0.40 or 0.35 mg/kg) delivered 1 hr before each convulsive stimulation. In Experiment IB, the rats tolerant to the anticonvulsant effects of phenobarbital, trimethadione, or clonazepam received bidaily injections of carbamazepine (35 mg/kg, IP), administered 1 hr before each stimulation. There was a statistically significant transfer of tolerance from phenobarbital to carbamazepine, but not from either trimethadione or clonazepam to carbamazepine. Thus, cross tolerance appears to be greatest between anticonvulsant drugs that are effective against a similar profile of clinical and experimental seizures and that have similar mechanisms of action. In Experiment 2A, tolerance developed to the anticonvulsant effect of bidaily pentobarbital (15 mg/kg, IP) injections only in those rats that received the drug 1 hr before the convulsive stimulation, but not in those rats that had received the drug 1 hr after each stimulation. Furthermore, those rats that had received the convulsive stimulations while under the influence of pentobarbital subsequently displayed a greater degree of cross tolerance to the anticonvulsant effect of ethanol (1.5 g/kg, IP) than those that had received the drug after each stimulation (contingent cross tolerance). Experiment 2B was the converse of Experiment 2A: contingent tolerance was demonstrated to ethanol and contingent cross tolerance to pentobarbital. This study provided the first unambiguous and bidirectional demonstration that the drug-effect contingency plays an important role in the development of cross tolerance. In Experiment 3, tolerance to the anticonvulsant effect of ethanol dissipated when bidaily pentobarbital (15 mg/kg, IP) injections were delivered 1 hr after each convulsive stimulation (contingent cross-dissipation of tolerance), but did not dissipate when it was delivered 1 hr before each stimulation. Thus, the drug-effect contingency was shown to be important in the dissipation of tolerance to one drug following the administration of another drug. In Experiment 4, different groups of rats received different doses of pentobarbital (10-50 mg/kg, IP) on a bidaily schedule 1 hr before the convulsive stimulation. Greater tolerance was found to the anticonvulsant effect of pentobarbital in rats that had received successively larger doses of the drug, none of which were large enough to suppress the convulsions, than those rats that were maintained on a high dose of the drug that completely suppressed the convulsions. The greater tolerance in the group that received successively greater doses was attributed to the fact that the convulsions were experienced in the drugged state. This study challenged the generally accepted view that tolerance develops more rapidly and to a greater extent with larger drug doses . This thesis provides the first unambiguous and systematic evidence of the role of the drug-effect contingency in the transfer of tolerance from one drug to another, and in the dissipation of tolerance to one drug following the administration of another. On the basis of the present experiments, several elaborations were proposed to the drug-effect theory of drug tolerance, which claims that tolerance develops to drug effects and not to drug exposure per se.
Arts, Faculty of
Psychology, Department of
Graduate

APA, Harvard, Vancouver, ISO, and other styles

5

Feeney, Thomas P. "Effects of drug dependence on matrimonial consent." Online full text .pdf document, available to Fuller patrons only, 2003. http://www.tren.com.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Lau, Phyllis Min-yu. "Adverse drug reactions in oncology." Monash University, Dept. of Pharmacy Practice, 2003. http://arrow.monash.edu.au/hdl/1959.1/5549.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Hasegawa, Takaaki, Kenji Takagi, and Kiyoyuki Kitaichi. "Effects of Bacterial Endotoxin on Drug Pharmacokinetics." 名古屋大学医学部, 1999. http://hdl.handle.net/2237/6203.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Buggins, Talia Rae. "Effects of pharmaceutical excipients on drug disposition." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55658/.

Full text

Abstract:

This thesis investigates the potential of some commonly used pharmaceutical excipients to alter drug pharmacokinetics. In breath test studies, 3.2ml/kg DMSO prolonged the half-life of 14C-aminopyrine, -erythromycin and -NDMA, indicating in vivo inhibition of metabolism by CYP3A (erythromycin), CYP2E1 (NDMA) and the variety of enzymes that metabolise aminopyrine (CYP 2C11, 2C12, 2B1 and 2B2). However, no effects were apparent at doses typically used in pre-clinical formulations. Aminopyrine and erythromycin breath tests were not affected by propylene glycol (PG) or Solutol HS15, however PG did significantly increase 14C02 exhalation half- life in the NDMA breath test, suggesting a specific effect on metabolism by CYP2E1. While two 2ml/kg doses of DMSO increased plasma ai-AGP levels, none of the excipients tested consistently affected plasma ai-AGP at doses commonly used in pre-clinical formulations, suggesting that they are unlikely to increase protein binding by this mechanism. Transport studies in MDCK-MDR1 cells demonstrated an inhibitory effect of 0.1% Tween 80 and Solutol HS15 on P-Gp. In vivo, Tween inhibited the biliary elimination of 99mTc-MIBI but not 99mTc-HIDA, indicating inhibition of P-Gp, while Solutol inhibited the biliary elimination of both radiopharmaceuticals, suggesting inhibition of MRP and possibly P-Gp. Pre-treatment with 4ml/kg DMSO substantially impaired the renal elimination of 99mTc-DTPA. In contrast, 20% 1.8ml/kg DMSO significantly increased 99mTc-DTPA uptake into the kidneys, suggesting an increase in GFR. Both Tween and Solutol delayed 99mTc-DTPA elimination from the kidneys in some rats, without affecting GFR. However, Solutol did not significantly affect the pharmacokinetics of OAT or OCT substrates, suggesting it did not affect active renal secretion by these transporters. These results demonstrate that excipients can influence drug pharmacokinetics in vivo, after a single acute dose at levels commonly used in pre clinical studies.

APA, Harvard, Vancouver, ISO, and other styles

9

Bradshaw, Jennifer Jean. "Isoflurane : interaction with hepatic microsomal enzymes." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/27138.

Full text

Abstract:

lsoflurane interacts with cytochrome P-450 in rat and human hepatic microsomes and the Δ6- and Δ5-desaturases in rat hepatic microsomes. The interaction of isoflurane with cytochrome P-450 results in its metabolism to fluoride ion and organofluorine metabolites. The cytochrome P-450 isozymes catalysing the defluorination of isoflurane were assessed in hepatic microsomes from phenobarbital-, β-naphthoflavone- and pregnenolone-16α-carbonitrilepretreated and untreated rats. One or more of the cytochrome P-450 isozymes induced by phenobarbital and pregnenolone-16α-carbonitrile appear to defluorinate isoflurane, but those induced by β-naphthoflavone do not. From a comparison of the extent of defluorination of isoflurane in hepatic microsomes from phenobarbital- and pregnenolone-16α-carbonitrile-pretreated rats, and their Kₘ and Vₘₐₓ values, it appears that isoflurane is defluorinated by one or more isozymes induced by both phenobarbital and pregnenolone-16α-carbonitrile. The major isozyme is probably cytochrome P-450PCN1. The metabolites of isoflurane were identified in human and phenobarbital-induced rat hepatic microsomes. In microsomes from phenobarbital-pretreated rats, isoflurane is metabolised to fluoride ion and trifluoroacetaldehyde; trifluoroacetic acid is not produced in measureable amounts. The trifluoroacetaldehyde produced binds to microsomal constituents. In human hepatic microsomes, the organofluorine metabolite is identified as trifluoroacetic acid. It is proposed that isoflurane is metabolised by different pathways in human and phenobarbital-induced rat hepatic microsomes. The interaction of isoflurane with the cyanide-sensitive factors was assessed by several criteria. Firstly, using the reoxidation of cytochrome b₅ as an index of fatty acid desaturase activity, isoflurane appears to interact with the Δ6- and/or Δ5-desaturases, but not the Δ9-desaturase. Secondly, these results were confirmed and clarified by the use of direct assays to measure the fatty acid desaturase activity. Using the direct assay, we confirmed that isoflurane did not inhibit the Δ9-desaturase and inhibited Δ6-desaturation of linoleic acid, but not the Δ6-desaturation of α-linolenic acid. The inhibition of the Δ6-desaturation of linoleic acid occurred at low millimolar concentrations of isoflurane. lsoflurane inhibits the Δ5-desaturation of eicosa-8, 11, 14-trienoic acid to a small extent which is only apparent at much higher concentrations of isoflurane than that which inhibits the Δ6-desaturase. Further studies focussed on measurement of the activity of Δ6-desaturase in order to attempt to study the kinetics of the inhibition of the Δ6-desaturase by isoflurane: Δ6-desaturase activity was assessed using hepatic microsomes as the source of the enzyme and linoleic acid as substrate precursor. In the course of these studies, we identified a number of factors that affected the apparent activity of the Δ6-desaturase in hepatic microsomes. These included significant levels of endogenous substrate and competing reactions in the hepatic microsomes. Endogenous substrate levels were quantified and corrected for. We then resorted to computer modelling to extract the kinetics of the Δ6-desaturase free of contributions from acyl-CoA synthetase and lysophospholipid acyltransferase, as well as enzyme decay. The kinetics of isoflurane inhibition of the Δ6-desaturase were then superimposed and studied by computer modelling.

APA, Harvard, Vancouver, ISO, and other styles

10

Sangfelt, Olle. "Effects of interferon on cellular proliferation and apoptosis /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19981014sang.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Bhatnagar, Barkha. "An examination of the effects of ivermectin on Brugia malayi adult worms /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100768.

Full text

Abstract:

Brugia malayi is one of the causative agents of the disabling and disfiguring disease known as Lymphatic Filariasis (LF). This infection is a well-established ailment in tropical and subtropical countries and recently the drug ivermectin has been introduced for the LF control programs. Ivermectin (IVM) is an excellent microfilaricide, but is not markedly macrofilaricidal. However, it causes a long-lasting reduction in the production of new larvae by female worms, suggesting that adult stages are affected. However, the mechanism by which IVM produces such effect in the adult worm is not well understood. One major reason is our incomplete understanding about the biological effect of IVM on adult stages. The present study was carried out to examine the in vitro effects of IVM on B. malayi adult worms using Brugia-gerbil animal model. And also to have some leads in understanding the drug-uptake and location of probable targets in the worm body by using fluorescent labeled IVM and confocal microscopy.
The antifilarial effects of IVM were examined using three parameters: mf release by female worms, and motility, and viability in both male and female worms. The results reported in this study demonstrate that although IVM did not kill the adult worm, but showed significant antifilarial effects on B. malayi adult stages when examined in an in vitro system. Confocal microscopy images of the worms incubated in bodipy FITC-IVM showed strong specific localization signal in the anterior cephalic region of both male and female worms. These observations suggest the early/initial interactions of the drug with its probable receptors that could be located specifically in the head region.

APA, Harvard, Vancouver, ISO, and other styles

12

Appelskog, Ioulia. "Effects of imidazoline compounds on intracellular CA²⁺ and apoptosis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4654-X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Walter, Sandra M. "Examining the effects of drug testing on drug use at the secondary education level." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1048380.

Full text

Abstract:

The primary purpose of this study was to determine if a drug testing program could impact or change student drug use at the secondary education level. Secondary purposes were to 1) assess the perceptions of secondary education students toward licit and illicit drugs, drug use, and the newly implemented drug testing program, and 2) to examine why drug use may continue even after a drug testing program has been implemented. Data was collected through the use of questionnaires, discussion groups, and one-on-one interviews. Examination of the questionnaire data indicated that student drug use was not substantially deterred by the newly implemented drug testing program over a three to four month time period. Also, students' perceptions of the newly implemented drug testing program were mainly that of disagreement. Students commented that they felt the drug testing policy was implemented to "catch them" using drugs rather than "help them" with a possible drug addiction. One of the main reasons that the drug testing program did not have a great deterrent effect on student drug use, as suggested by the students, was that the odds were not high enough that they would be selected to be drug tested. In some instances, drug testing was not proving to be a deterrent to drug use, but rather a deterrent to participation in school activities. However, for some students, drug testing was proving to be a deterrent to drug use. As quoted from one of the discussion group members: "It's a step in the right direction."
School of Physical Education

APA, Harvard, Vancouver, ISO, and other styles

14

Hughes, D. R. L. "The influence of gastrointestinal mucus on drug absorption." Thesis, University of Brighton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382271.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Kechagias, Stergios. "Clinical pharmacokinetics of small doses of ethanol : role of gastric emptying and other influences in the upper gastrointestinal tract /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med682s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Nyberg, Joakim. "Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160481.

Full text

Abstract:

The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. Optimal experimental design (OD) describes the procedure of maximizing relevant information in drug development and drug treatment processes. While various optimization criteria can be considered in OD, the most common is to optimize the unknown model parameters for an upcoming study. To date, OD has mainly been used to optimize the independent variables, e.g. sample times, but it can be used for any design variable in a study. This thesis addresses the OD of multiple continuous or discrete design variables for nonlinear mixed effects models. The methodology for optimizing and the optimization of different types of models with either continuous or discrete data are presented and the benefits of OD for such models are shown. A software tool for optimizing these models in parallel is developed and three OD examples are demonstrated: 1) optimization of an intravenous glucose tolerance test resulting in a reduction in the number of samples by a third, 2) optimization of drug compound screening experiments resulting in the estimation of nonlinear kinetics and 3) an individual dose-finding study for the treatment of children with ciclosporin before kidney transplantation resulting in a reduction in the number of blood samples to ~27% of the original number and an 83% reduction in the study duration. This thesis uses examples and methodology to show that studies in drug development and drug treatment can be optimized using nonlinear mixed effects OD. This provides a tool than can lower the cost and increase the overall efficiency of drug development and drug treatment.

APA, Harvard, Vancouver, ISO, and other styles

17

Loftenius, Annika. "Effects of mercury and fluoride on human immune cells : elucidation of mechanisms /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3304-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Köhler, Camilla. "Mechanisms of apoptosis induced by a protein complex isolated from human milk : with focus on the role of mitochondria /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-048-2/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Mathé, Jan M. "The phencyclidine model of schizophrenia : dysregulation of brain dopamine systems induced by NMDA receptor antagonists : an experimental study /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980930math.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Luhr, Owe. "Acute lung injury : incidence and predictors of outcome with special reference to inhaled nitric oxide /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3456-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Rimondini-Giorgini, Roberto. "Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3617-X/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Stridh, Hélène. "The role of the mitochondrion in organotin-induced T-cell apoptosis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3917-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Wennborg, Helena. "Health effects in biomedical research laboratory personnel in Sweden : cancer occurrence and reproductive outcomes /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4087-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Berninger, Erik. "Quinine as a model for the study of cochlear hearing loss in humans /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4272-2/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Ahlbom, Eva. "Neuronal and endocrine cells' susceptibility to physiologic and toxic stimuli : a study on the effects of steroid hormones /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4278-1/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Della, Penna Greg. "Stromal cell effects on melanoma cell drug response." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12086.

Full text

Abstract:

Thesis (M.A.)--Boston University
Objective: Melanoma is currently one of the deadliest forms of skin disease in the United States. However in the past decade there have been significant advances in treatment. Among the most promising recent developments, inhibitors of the serine/threonine-protein kinase B-Raf (BRAF inhibitors) such as vemurafenib show great promise and have been shown to increase the median survival of patients with melanoma cells that harbor a mutation of the BRAF gene. While BRAF inhibitors and other treatment therapies have much potential, more needs to be done to improve treatment. As with other cancers, a major hurdle in the treatment of melanoma is the eventual tumor resistance to drug therapy. Accessory cells are thought to play a large role in mediating tumor resistance to drug treatment. Stromal cells have been known to release cytokines and growth factors that aid in cancer proliferation. They can also expression adhesion molecules that further help to aid cell growth and tumor development. It has also been demonstrated that these accessory cells can significantly alter cancer cell drug response as a result of the factors they release or express on their surface. In this study we hypothesize that certain anti-cancer drugs will behave differently against melanoma cell line A375 in the presence versus the absence of stromal cells. Methods: Melanoma cell line A375 was grown on 384 well plates in the presence or absence of different stromal cell lines. A number of different drugs were screened using Compartment-Specific Bioluminescence Imaging to determine if there was a difference in A375 proliferation after drug treatment in the presence versus absence of accessory cells. After an initial screen, a few drugs were chosen to generate dose-response curves to determine if different drugs had different effects at various doses in the presence or absence of stromal cells. [TRUNCATED]

APA, Harvard, Vancouver, ISO, and other styles

27

TONON, FEDERICA. "Exploring drug molecular effects in cancer disease models." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908483.

Full text

Abstract:

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. As usually HCC diagnosis occurs in the advanced stage of the disease, available treatments such as resection, liver transplant, or local ablation are poorly if not at all effective. Also systemic chemotherapy has limited effectiveness. The only drug that can prolong patient survival is Sorafenib; unfortunately, however, the extent of increased survival is very modest being of few months. Together the above considerations clearly indicate that the development of novel therapeutic approaches for HCC are urgently necessary. The demethylation agent 5-Azacytidine (5-AZA) is considered to be of great potential therapeutic value. This is due to the emerging knowledge of the important role of epigenetic modulation in HCC development and to the fact that the use of demethylation agents gave encouraging results in cultured human HCC derived cells. Working with different cellular models of HCC (JHH6, HUH7, IHH) we got evidence of the potent anti-proliferative (cell counting, MTT, flow-cytometry, immuno-fluorescence) and anti-migratory (scratch assay, trans-well test, microscopic live observation of migration) effects of 5-AZA. Functional molecular analysis revealed that, upon 5-AZA treatment, a strong up-regulation of miRNA 139-5p occurs. This in turn causes the down regulation of the Rho-associated coiled-coil-containing protein kinase 2 (ROCK2), a known target of miRNA 139-5p. ROCK2 inhibition then results in the reduced stabilization of the gelatinase MMP2, paralleled by the reduction of MMP2 activity (as evaluated by zymography). In addition, ROCK2 down regulation leads to the decrease in the expression of other targets including Cyclin D1, E2F1 and Pin-1, all proliferative genes. Thus, the potent anti-migratory and anti-proliferative effects of 5-AZA may occur via the inhibition of pathways miRNA139-5p/ROCK2/MMP2 and miRNA139-5p/ROCK2/CyclinD1/E2F1/Pin-1 pathway, respectively. Finally, we have observed in a preliminary experiment in SCID xenograft mouse model of HCC that the intra-tumour injection of 5-AZA administered in two consecutive rounds, can significantly reduce tumour growth prolonging animal survival. The effectiveness of 5-AZA against HCC we observed can significantly contribute to bring 5-AZA closer to the clinical use for HCC.

APA, Harvard, Vancouver, ISO, and other styles

28

Heiberg, Ludvig. "An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/27187.

Full text

Abstract:

Although there have been two-dimensional electrophoretic studies on fetal brain tissue (for instance, Yoshida and Takahashi, 1980), the emphasis in most of this work has been on developmental changes in protein expression, and not on the effects that drugs have on fetal brain protein complement. Klose and co-workers (1977) did an early study using two-dimensional gel electrophoresis to determine the effects of various teratogens on whole embryos. No protein changes were found and that line of research was not continued. In this study two-dimensional gel electrophoresis is extensively used, in the belief that the usefulness of this technique to experimental teratology has not been fully evaluated. It is reasonable to suppose that a central nervous system teratogen administered during critical periods of susceptibility will led to perturbations of orderly brain development, and that these perturbations will be reflected as changes to the protein complement. The total brain protein complement of mice that have been exposed to drugs in utero will therefore be analysed, in the hope that any inductions or deletions of proteins as a result of drug exposure may provide a clue to the molecular events underlying drug injury to the fetus.

APA, Harvard, Vancouver, ISO, and other styles

29

Mutni, A. N. "Effects on anti-hyperlipidaemic drugs on the liver." Thesis, Bucks New University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382585.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Wright, A. "Structural changes in the human cochlea during drug treatment." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371567.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Maskaly, Jonathan. "The displacement effects of a police drug crackdown on open air markets and drug houses." abstract and full text PDF (UNR users only), 2009. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1464450.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Polotskaia, Anna. "Response of motor and cognitive speed to increasing doses of methylphenidate in children diagnosed with attention deficithyperactivity disorder." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116112.

Full text

Abstract:

This study has examined the effect of 3 doses of Methylphenidate (MPH) on the speed of motor and cognitive performance in children diagnosed with ADHD. Thirty children clinically diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) aged 6-12 years were recruited through the ADHD Clinic and the Severe and Disruptive Behavior Disorders Program at the Douglas Mental Health University Institute. The three doses of MPH were administered according to a double blind randomized cross-over three day trial (0.3; 0.5 0.8 mg/kg/day in a bid schedule). An improvement across all three doses of MPH on motor, cognitive and behavioural measures was observed. The improvement is significant at low doses of MPH and an increase of dose up to 0.8 mg/kg/day does not lead to further improvement of the speed of simple motor task, but might be beneficial to specific cognitive tasks. No deterioration was observed in association with higher doses of MPH.

APA, Harvard, Vancouver, ISO, and other styles

33

Ryan, Heather E. "Marijuana use and its cognitive effects." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1337204.

Full text

Abstract:

The present study compared three commonly used cognitive screeners: the Test of Cognitive Skills – Second Edition (TCS-2), the Kaufman Brief Intelligence Test (K-BIT), the Wide Range Achievement Test – Third editions (WRAT3) and the impact of marijuana use on these screeners in a population of juvenile delinquents. One hundred records (67 males and 33 females) were selected from archival data at the Allen County Juvenile Center. Results from this study found, that as predicted, individuals who tested positive for marijuana performed significantly worse on all subtests of the TCS-2, on the Verbal and Composite Score of the K-BIT, and the Spelling subtest of the WRAT3 than individuals who tested negative for marijuana use. The results of this study support the notion that marijuana can impair cognitive abilities in a group of adolescents.
Department of Psychological Science

APA, Harvard, Vancouver, ISO, and other styles

34

Gumbleton, M. "Influence of anaesthetics on renal function and drug deposition." Thesis, Bucks New University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Banna, Kelly Marie Newland M. Christopher. "Drug effects on behavior in transition does context matter? /." Auburn, Ala., 2007. http://repo.lib.auburn.edu/EtdRoot/2007/FALL/Psychology/Dissertation/BANNA_KELLY_36.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Chen, C. H. "Neuroimaging studies of affective disorders and antidepressant drug effects." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597540.

Full text

Abstract:

This thesis investigated abnormalities in the brain circuitry for affect processing in patients with affective disorders, and effects of antidepressant drugs on this circuitry. The first experimental study examined brain activation in response to an implicit and explicit facial recognition task by employing functional magnetic resonance imaging (fMRI) in a group of 8 manic and 8 depressed patients with bipolar disorder and 8 healthy comparison controls. This comparison showed that depressed and manic patients exhibited over activated responses to fearful faces, as well as to mood-incongruent facial expressions, with the depressed group exhibiting over-activity in fronto-striato-thalamic systems in response to happy faces, and the manic group over-activity in the fusiform gyrus in response to sad faces. For manic patients, task type also affected the neural response to sad faces, with the cortico-limbic regions showing over-activation for implicit processing and under-activation for explicit processing. In the following part of the thesis, the neurophysiology underlying major depression and neural correlates of antidepressant drug effects were studied. Brain activation in response to the implicit sad facial recognition task, and brain structure, were examined in a group of 17 patients with major depression using functional and structural MRI before and after a course of 8 weeks antidepressant treatment. Faster rates of symptom improvement were strongly associated with greater grey matter volume in the anterior cingulated cortex, insula and right temporo-parietal cortex. Patients with greater than median grey matter volume in this system had faster rates of improvement and significantly lower residual symptoms scores after treatment. Faster improvement was also predicted by greater functional activation of the anterior cingulated cortex. Depressive symptom severity was negatively correlated with greater grey matter volume in the dorsal prefrontal and anterior midcingulate regions anatomically distinct from the pregenual and subgenual cingulate regions predicting treatment response. Furthermore, patients with major depression were compared with 19 matched healthy controls to investigate changes in the effective connectivity between the amygdala and all other brain areas in response to facial emotions at baseline and after antidepressant treatment. The results indicate that antidepressant drug effects can be measured in terms of altered connectivity between components of cortico-limbic systems.

APA, Harvard, Vancouver, ISO, and other styles

37

Konnanov, P. "Microprocessor evaluation of drug effects on car driving skills." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Chan, Kin Tak. "Investigations of p53 mutations and effects on drug resistance /." View abstract or full-text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20CHAN.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Albert, Johanna. "Effects of nitric oxide on hemostasis with special attention to platelet function /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3783-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Custodio, Joseph M. "Predicting intestinal transporter effects in food-drug interactions and the role of food on drug absorption." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324590.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Carvajal-Pinal, M. Teresa. "Effects of drug crystal polymorphism on the drug carrier interactions in dry powder mixes for inhalation." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341642.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Florian, Maria 1953. "The role of estrogen in the maintenance of healthy endothelium /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111873.

Full text

Abstract:

The place of estrogen in women's health remains controversial. Premenopausal women have a lower prevalence of cardiovascular disease (CVD) than men and in observational studies hormone replacement therapy (HRT) decreases CVD in postmenopausal women. However, prospective randomized trials of secondary and primary prevention have failed to substantiate an overall protective effect from HRT and have even shown some harm. To explain this paradox it is necessary to better understand the effects of estrogen on the vascular wall. Estrogen rapidly mediates the activation of eNOS and increases the production of nitric oxide (NO), an important factor for endothelial health. In ovariectomized rats estrogen reduces production of superoxide (O2-) by NAD(P)H oxidase. The decreased function is associated with a decrease in the p47phox component of NAD(P)H oxidase and its interaction with the multicomponent enzyme. In these rats estrogen did not alter eNOS expression and bioavailability of NO, which is in contrast to its acute effects. This highlights the difference between chronic and acute studies. The decrease in O2-production suggests the intracellular signaling.
Estrogen has antiapoptotic effects. Oxidized low-density lipoprotein (oxLDL) and the inflammatory cytokine TNFalpha increased apoptosis which is associated with atherosclerosis. In human umbilical vein endothelial cells (HUVEC), estrogen decreased the extent of TNFalpha and oxLDL induced apoptosis as indicated by the expression of cleaved caspase-3 and FACS assay. Estrogen also preserves the antiapoptotic mitochondrial Bcl-2 and Bcl-xL proteins.
Estrogen has angiogenic properties that can help a healthy endothelium respond to injury. However, estrogen increases the angiogenesis caused by TNFalpha and this could lead to revascularization in the plaques of women with advanced disease.
Overall the balance between the positive and negative aspects of the effects of estrogen on the vascular wall could explain the paradoxical response in older women.

APA, Harvard, Vancouver, ISO, and other styles

43

Demirbas, Ucpinar Sibel. "Oligonucleotides and protease inhibitors transport across CaCo-2 cell monolayers-permeability effects of dimethylsulfoxide and citicholine /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Dricu, Anica. "Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2751-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Rosdahl, Hans. "Microdialysis sampling from skeletal muscle and adipose tissue with special reference to the effects of insulin on tissue blood flow and glucose metabolism /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3050-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Johnson, Hans. "Spinal motoneurons and the bulbospinal serotoninergic system in aged rats with behavioral deficits /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3277-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Le, Blanc Katarina. "Platelet function in polycythemia vera : studies of agonist and cytokine induced platelet activation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3442-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Petersson, Maria. "Short- and long-term cardiovascular and behavioural effects of oxytocin : mechanisms involved and influence of female steroid hormones /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3503-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Wanecek, Michael. "The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3707-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Förander, Petter. "On the actions of neurotrophic factors on the chromaffin cells of the adrenal medulla /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4145-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!