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Journal articles on the topic 'Drug delivery matrices'

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Published: 7 July 2024

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1

You, Jin-Oh, Dariela Almeda, George JC Ye, and Debra T. Auguste. "Bioresponsive matrices in drug delivery." Journal of Biological Engineering 4, no. 1 (2010): 15. http://dx.doi.org/10.1186/1754-1611-4-15.

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2

Nayak, Amit K., Md Saquib Hasnain, Sitansu S. Nanda, and Dong K. Yi. "Hydroxyapatite-alginate Based Matrices for Drug Delivery." Current Pharmaceutical Design 25, no. 31 (November 14, 2019): 3406–16. http://dx.doi.org/10.2174/1381612825666190906164003.

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Background: Hydroxyapatite (HAp) is a biocompatible bioceramic compound by nature and widely utilized in a broad range of biomedical applications, especially in drug delivery, tissue engineering, orthopedics, dentistry, etc. To intensify its usage, HAp is being reinforced with different biopolymer(s). In these bioceramicbiopolymeric systems, HAp crystallites have been well inviolate with the alginate molecules. The objective of this review article is to present a comprehensive discussion of different recently researched drug-releasing potential by HAp-alginate based matrices. Methods: During past few years, HAp particles (both synthesized and naturally derived) have been reinforced within different alginate-based systems to load a variety of drug candidates. Most of the reported drug-releasing HAp-alginate based matrices were prepared by the methodology of ionic-gelation of sodium alginate followed by air-drying/spray drying process. Results: HAp-alginate systems have already been proved as useful for loading a variety of drugs and also resulting sustained drug delivery with minimizing the drawbacks of pure alginate matrices (such as burst drug-releasing and low mechanical property in the alkaline pH). Conclusion: HAp-alginate composites loaded with different kinds of drugs have already been reported to exhibit sustained releasing of loaded drugs over a longer period.
3

Manzano, Miguel, Montserrat Colilla, and María Vallet-Regí. "Drug delivery from ordered mesoporous matrices." Expert Opinion on Drug Delivery 6, no. 12 (November 26, 2009): 1383–400. http://dx.doi.org/10.1517/17425240903304024.

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4

Mucha, Maria, Iwona Socha-Michalak, and Jacek Balcerzak. "Biodegradable Polymers as Matrices for Control Drug Delivery." Advanced Materials Research 911 (March 2014): 336–41. http://dx.doi.org/10.4028/www.scientific.net/amr.911.336.

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In the paper the results of control drug release from different forms of carriers are presented. Dibutyrylchitin, chitosan, polylactid acid and polycaprolactone have been used as matrices for delivery of therapeutic substances (ibuprofen and salicylic acid). Two configurations of matrices for drug delivery have been found. Flat drug delivery systems (films) and spherical matrices (beads) were tested in the aim of control drug transport. To control the drug release, matrices have been modified. The release of active substances from films has been tested in buffer solution of pH 5.5. Spherical matrices have been tested in buffer solutions of pH 1.4 and pH 7.2. To experimental data First order and two stage models were fitted.
5

Chiarappa, Gianluca, Michela Abrami, Barbara Dapas, Rossella Farra, Fabio Trebez, Francesco Musiani, Gabriele Grassi, and Mario Grassi. "Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices." Natural Product Communications 12, no. 6 (June 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200610.

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The new concept of personalized medicine and the affirmation of Nucleic Acid Based Drugs (NABDs), an emerging class of bio-drugs constituted by short sequences of either DNA or RNA, represent a new challenge for the mathematical modelling in the drug delivery and adsorption field. Indeed, whether patient uniqueness asks for the use of theoretical tools enabling a rational approach adapting to each patient, NABDs delivery brings to our attention new aspects of drug delivery due to the NABDs fragile nature and way of action. This review aims to present and discuss the mathematical modelling of drug release from natural polysaccharides matrices with particular care to the description of the chemical and physical phenomena ruling drug delivery.
6

Singh, Shrishti, and Jeffrey Moran. "Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices." Micromachines 12, no. 10 (October 6, 2021): 1216. http://dx.doi.org/10.3390/mi12101216.

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For effective treatment of diseases such as cancer or fibrosis, it is essential to deliver therapeutic agents such as drugs to the diseased tissue, but these diseased sites are surrounded by a dense network of fibers, cells, and proteins known as the extracellular matrix (ECM). The ECM forms a barrier between the diseased cells and blood circulation, the main route of administration of most drug delivery nanoparticles. Hence, a stiff ECM impedes drug delivery by limiting the transport of drugs to the diseased tissue. The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. Here, we provide a comprehensive look at the current ECM models in use to mimic the in vivo diseased states, the different types of SPPs that have been experimentally tested in these models, and suggest directions for future research toward clinical translation of SPPs in diverse biomedical settings.
7

Cheaburu-Yilmaz, Catalina, Catalina Lupuşoru, and Cornelia Vasile. "New Alginate/PNIPAAm Matrices for Drug Delivery." Polymers 11, no. 2 (February 20, 2019): 366. http://dx.doi.org/10.3390/polym11020366.

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This paper deals with a comparative study on the interpolymeric complexes of alginate poly(N-isopropyl acryl amide (PNIPAAm) and corresponding graft copolymers with various compositions in respect to their toxicity, biocompatibility and in vitro and in vivo release of theophylline (THP). Loading of the various matrices with theophylline and characterization of loaded matrices was studied by near infrared spectroscopy–chemical imaging (NIR–CI) analysis, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). It was appreciated that THP loading is higher than 40% and the drug is relatively homogeneous distributed within all matrices because of some specific interactions between components of the system. All samples have been found to be non-toxic and biocompatible. It was established that graft copolymers having a good stability show a better drug carrier ability, a higher THP loading, a prolonged release (longer release duration for graft copolymers of 235.4–302.3 min than that for IPC 72/28 of 77.6 min, which means approximately four times slower release from the graft copolymer-based matrices than from the interpolymeric complex) and a good bioavailability. The highest values for THP loading (45%), prolonged release (302.3 min) and bioavailability (175%) were obtained for graft copolymer AgA-g-PNIPAAm 68. The drug release mechanism varies with composition and architecture of the matrix.
8

Ezzat, Kariem, Samir Andaloussi, Rania Abdo, and Ulo Langel. "Peptide-Based Matrices as Drug Delivery Vehicles." Current Pharmaceutical Design 16, no. 9 (March 1, 2010): 1167–78. http://dx.doi.org/10.2174/138161210790963832.

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9

Moghadam, S. H., H. W. Wang, E. Saddar El-Leithy, C. Chebli, and L. Cartilier. "Substituted amylose matrices for oral drug delivery." Biomedical Materials 2, no. 1 (March 2007): S71—S77. http://dx.doi.org/10.1088/1748-6041/2/1/s11.

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10

Foster, Thomas, Corina Ionescu, Daniel Walker, Melissa Jones, Susbin Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian, and Hani Al-Salami. "Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices." Therapeutic Delivery 12, no. 10 (October 2021): 723–37. http://dx.doi.org/10.4155/tde-2021-0050.

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Advancement in the prevention of chemotherapy-induced hearing loss has proposed new nano-based delivery matrices that can target inner ear regions most damaged by chemotherapy. Chemotherapy agents (e.g., cisplatin) induce increased reactive oxygen species formation in the inner ear that damage sensory hair cells and result in irreversible hearing impairment. Exogenous antioxidants (e.g., Probucol and metformin) have been shown to block the formation of these reactive oxygen species. Delivery of these drugs in effective concentrations remains a challenge. Microencapsulation in combination with drug excipients provides one technique to effectively deliver these drugs. This paper investigates the use of probucol and metformin in combination with drug excipients for novel, inner ear, delivery.
11

Khan, Taif Ali, Abul Kalam Azad, Shivkanya Fuloria, Asif Nawaz, Vetriselvan Subramaniyan, Muhammad Akhlaq, Muhammad Safdar, et al. "Chitosan-Coated 5-Fluorouracil Incorporated Emulsions as Transdermal Drug Delivery Matrices." Polymers 13, no. 19 (September 29, 2021): 3345. http://dx.doi.org/10.3390/polym13193345.

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The purpose of the present study was to develop emulsions encapsulated by chitosan on the outer surface of a nano droplet containing 5-fluorouracil (5-FU) as a model drug. The emulsions were characterized in terms of size, pH and viscosity and were evaluated for their physicochemical properties such as drug release and skin permeation in vitro. The emulsions containing tween 80 (T80), sodium lauryl sulfate, span 20, and a combination of polyethylene glycol (PEG) and T20 exhibited a release of 88%, 86%, 90% and 92%, respectively. Chitosan-modified emulsions considerably controlled the release of 5-FU compared to a 5-FU solution (p < 0.05). All the formulations enabled transportation of 5-FU through a rat’s skin. The combination (T80, PEG) formulation showed a good penetration profile. Different surfactants showed variable degrees of skin drug retention. The ATR-FTIR spectrograms revealed that the emulsions mainly affected the fluidization of lipids and proteins of the stratum corneum (SC) that lead to enhanced drug permeation and retention across the skin. The present study concludes that the emulsions containing a combination of surfactants (Tween) and a co-surfactant (PEG) exhibited the best penetration profile, prevented the premature release of drugs from the nano droplet, enhanced the permeation and the retention of the drug across the skin and had great potential for transdermal drug delivery. Therefore, chitosan-coated 5-FU emulsions represent an excellent possibility to deliver a model drug as a transdermal delivery system.
12

Wagle, Susbin Raj, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian, and Hani Al-Salami. "Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations." Pharmaceutics 12, no. 8 (July 29, 2020): 708. http://dx.doi.org/10.3390/pharmaceutics12080708.

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Bile acids have recently been studied for potential applications as formulation excipients and enhancers for drug release; however, some bile acids are not suitable for this application. Unconjugated lithocholic acid (ULCA) has recently shown drug formulation-stabilizing and anti-inflammatory effects. Lipophilic drugs have poor gut absorption after an oral dose, which necessitates the administration of high doses and causes subsequent side effects. Probucol (PB) is a highly lipophilic drug with poor oral absorption that resulted in restrictions on its clinical prescribing. Hence, this study aimed to design new delivery systems for PB using ULCA-based matrices and to test drug formulation, release, temperature, and biological effects. ULCA-based matrices were formulated for PB oral delivery by applying the jet-flow microencapsulation technique using sodium alginate as a polymer. ULCA addition to new PB matrices improved the microcapsule’s stability, drug release in vitro (formulation study), and showed a promising effect in ex vivo study (p < 0.05), suggesting that ULCA can optimize the oral delivery of PB and support its potential application in diabetes treatment.
13

Feldstein, M. M., V. N. Tohmakhchi, L. B. Malkhazov, A. E. Vasiliev, and N. A. Platé. "Hydrophilic polymeric matrices for enhanced transdermal drug delivery." International Journal of Pharmaceutics 131, no. 2 (April 1996): 229–42. http://dx.doi.org/10.1016/0378-5173(95)04351-9.

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14

Goldraich, Marganit, and Joseph Kost. "Glucose-sensitive polymeric matrices for controlled drug delivery." Clinical Materials 13, no. 1-4 (January 1993): 135–42. http://dx.doi.org/10.1016/0267-6605(93)90100-l.

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15

Petersen, Ritika Singh, Stephan Sylvest Keller, and Anja Boisen. "Loading of Drug-Polymer Matrices in Microreservoirs for Oral Drug Delivery." Macromolecular Materials and Engineering 302, no. 3 (November 25, 2016): 1600366. http://dx.doi.org/10.1002/mame.201600366.

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16

Jayaraman, Arthi, Christopher Price, Millicent O. Sullivan, and Kristi L. Kiick. "Collagen-Peptide-Based Drug Delivery Strategies." Technology & Innovation 21, no. 4 (December 1, 2020): 1–20. http://dx.doi.org/10.21300/21.4.2020.9.

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Collagen-targeting strategies have proven to be an effective method for targeting drugs to pathological tissues for treatment of disease. The use of collagen-like peptides for controlling the assembly of drug delivery vehicles, as well as their integration into collagen-containing matrices, offers significant advantages for tuning the morphologies of assembled structures, their thermoresponsiveness, and the loading and release of both small-molecule and macro-molecular cargo. In this contribution, we summarize the design and development of collagen-peptide-based drug delivery systems introduced by the Kiick group and detail the expansion of our understanding and the application of these unique molecules through collaborations with experts in computational simulations (Jayaraman), osteoarthritis (Price), and gene delivery (Sullivan). Kiick was inducted as a Fellow of the National Academy of Inventors in 2019 and was to deliver an address describing the innovations of her research. Given the cancellation of the NAI Annual Meeting as a result of coronavirus travel restrictions, her work based on collagen-peptide-mediated assembly is instead summarized in this contribution.
17

Ukmar, Tina, and Odon Planinšek. "Ordered mesoporous silicates as matrices for controlled release of drugs." Acta Pharmaceutica 60, no. 4 (December 1, 2010): 373–85. http://dx.doi.org/10.2478/v1007-010-0037-4.

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Ordered mesoporous silicates as matrices for controlled release of drugs Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.
18

Khatoon, Nafeesa, Mao Quan Chu, and Chun Hui Zhou. "Nanoclay-based drug delivery systems and their therapeutic potentials." Journal of Materials Chemistry B 8, no. 33 (2020): 7335–51. http://dx.doi.org/10.1039/d0tb01031f.

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19

Leong, K. F., K. K. S. Phua, C. K. Chua, Z. H. Du, and K. O. M. Teo. "Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 215, no. 2 (February 1, 2001): 191–92. http://dx.doi.org/10.1243/0954411011533751.

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New techniques in solid freeform fabrication (SFF) have prompted research into methods of manufacturing and controlling porosity. The strategy of this research is to integrate computer aided design (CAD) and the SFF technique of selective laser sintering (SLS) to fabricate porous polymeric matrix drug delivery devices (DDDs). This study focuses on the control of the porosity of a matrix by manipulating the SLS process parameters of laser beam power and scan speed. Methylene blue dye is used as a drug model to infiltrate the matrices via a degassing method; visual inspection of dye penetration into the matrices is carried out. Most notably, the laser power matrices show a two-stage penetration process. The matrices are sectioned along the XZ planes and viewed under scanning electron microscope (SEM). The morphologies of the samples reveal a general increase in channel widths as laser power decreases and scan speed increases. The fractional release profiles of the matrices are determined by allowing the dye to diffuse out in vitro within a controlled environment. The results show that laser power and scan speed matrices deliver the dye for 8-9 days and have an evenly distributed profile. Mercury porosimetry is used to analyse the porosity of the matrices. Laser power matrices show a linear relationship between porosity and variation in parameter values. However, the same relationship for scan speed matrices turns out to be rather inconsistent. Relationships between the SLS parameters and the experimental results are developed using the fractional release rate equation for the infinite slab porous matrix DDD as a basis for correlation.
20

Matricardi, Pietro, Ilenia Onorati, Tommasina Coviello, and Franco Alhaique. "Drug delivery matrices based on scleroglucan/alginate/borax gels." International Journal of Pharmaceutics 316, no. 1-2 (June 2006): 21–28. http://dx.doi.org/10.1016/j.ijpharm.2006.02.024.

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Domb, Avi, and Antonios G. Mikos. "Matrices and scaffolds for drug delivery in tissue engineering." Advanced Drug Delivery Reviews 59, no. 4-5 (May 2007): 185–86. http://dx.doi.org/10.1016/j.addr.2007.05.001.

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22

Veres, Peter, Ana M. López-Periago, István Lázár, Javier Saurina, and Concepción Domingo. "Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs." International Journal of Pharmaceutics 496, no. 2 (December 2015): 360–70. http://dx.doi.org/10.1016/j.ijpharm.2015.10.045.

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23

Pagar, Anita H., and Ashish Y. Pawar. "A Birds Eye View on Solid Lipid Nanoparticles and Applications in Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (December 25, 2023): 1611–22. http://dx.doi.org/10.25258/ijddt.13.4.75.

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Solid lipid nanoparticles (SLN) might provide fresh opportunities for treating challenging ailments. The SLN were established in the 1990s to replace emulsions and liposomes, in addition to polymeric nanoparticles (NP) as carrier systems. SLN are wet cohesive dispersions with solid biodegradable lipids as their matrices. Drug delivery techniques called SLN use both liquid and solid lipids as their primary matrices. It was demonstrated that SLNs have several benefits over conventional carriers for drug therapy, a longer half-life, tissue-targeted administration, higher permeability, enhanced bioavailability, enhanced solubility, as well as the capacity to enhance storage stability. Because of their exclusive size-dependent characteristics as well as their capability towards incorporating drugs, SLN’s currently a possibility towards designing promising pharmacological prototypes for drug transport as well as targeting. The objective of tailored as well as monitored drug delivery is now unsettling researchers’ interests across the globe, and can be accomplished through the support of SLNs. The present investigation emphasizes SLNs’ numerous characteristics as well as development and evaluation processes, formulation factors, delivery routes, surface changes, toxicity, and biomedical applications
24

Ramírez Rigo, María V., Daniel A. Allemandi, and Ruben H. Manzo. "Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties." Drug Delivery 16, no. 2 (January 30, 2009): 108–15. http://dx.doi.org/10.1080/10717540802605848.

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25

Cubiça, Thássio Brandão, Raquel de Souza Ribeiro, Vinícius Guedes Gobbi, Talita Goulart da Silva, Debora Baptista Pereira, Hellen Regina Oliveira De Almeida, Tiago dos Santos Mendonça, and Roberta Helena Mendonça. "INCORPORATION AND RELEASE OF HAMAMELIS VIRGINIANA IN “SCAFFOLDS” PRECURSOR MATRIX: AN APPROACH WITH THE “THIN PLATE SPLINE” INTERPOLATION METHOD." REVISTA FOCO 16, no. 02 (February 3, 2023): e921. http://dx.doi.org/10.54751/revistafoco.v16n2-060.

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In recent years, tissue engineering has been developing methodologies to potentialize the regeneration of injured tissues, such as using biomaterials to obtain scaffolds performing the controlled release of drugs. The polymers polyhydroxy butyrate (PHB) and chitosan (CHI) have been used in the production of matrices applied to scaffold production. This study aims to produce and evaluate matrices containing different proportions of PHB and CHI using the compression molding technique. These matrices can form scaffolds after drug incorporation of Hamamelis virginiana (HV). In order to predict the swelling of the matrices, the Thin Plate Spline Interpolation method (TPSIM) was used to generate three-dimensional data fitted, showing the influence of time and concentration variables on drug absorption. Results show that the percentage of CHI in the samples determines the swelling degree of the matrices. According to scanning electron microscopy analyses, increasing this polymer's quantity modifies the matrix's morphology, making it more heterogeneous. The sample with 50% by weight composition of CHI showed better-swelling results and samples loaded with HV demonstrated drug release ability. Thus, the obtained matrices have great potential to work as scaffolds and drug delivery systems, and therefore, they are promising products for application in tissue engineering.
26

Ali, Fayaz, Imran Khan, Jianmin Chen, Kalsoom Akhtar, Esraa M. Bakhsh, and Sher Bahadar Khan. "Emerging Fabrication Strategies of Hydrogels and Its Applications." Gels 8, no. 4 (March 24, 2022): 205. http://dx.doi.org/10.3390/gels8040205.

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Recently, hydrogels have been investigated for the controlled release of bioactive molecules, such as for living cell encapsulation and matrices. Due to their remote controllability and quick response, hydrogels are widely used for various applications, including drug delivery. The rate and extent to which the drugs reach their targets are highly dependent on the carriers used in drug delivery systems; therefore the demand for biodegradable and intelligent carriers is progressively increasing. The biodegradable nature of hydrogel has created much interest for its use in drug delivery systems. The first part of this review focuses on emerging fabrication strategies of hydrogel, including physical and chemical cross-linking, as well as radiation cross-linking. The second part describes the applications of hydrogels in various fields, including drug delivery systems. In the end, an overview of the application of hydrogels prepared from several natural polymers in drug delivery is presented.
27

Thakur, Goutam, Analava Mitra, and Amit Basak. "GENIPIN CROSSLINKED DRUG–GELATIN COMPOSITE FOR DRUG TRANSPORT AND CYTOCOMPATIBILITY." Biomedical Engineering: Applications, Basis and Communications 23, no. 02 (April 2011): 113–18. http://dx.doi.org/10.4015/s101623721100244x.

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Gelatin-based drug carrier matrices have emerged as very promising class of delivery system. The purpose of this investigation was to develop drug loaded gelatin-based gels (composites). Gelatin matrices were crosslinked with genipin, a naturally occurring crosslinker for the release of indomethacin. Indomethacin, a low molecular weight and moderately hydrophobic, anti-inflammatory agent was incorporated into the gelatin matrices to form drug loaded gel composites for the release study. The gels were subjected to temperature-dependent oscillatory rheology. The result showed pouring temperature in the range of ~31–34°C for the un-crosslinked gels while the crosslinked gels did not show crossover point. Gels were studied for surface morphology using scanning electron microscopy and a porous network structure was observed. The release of indomethacin from the gels indicated an initial increase in the release rate with the increase in drug concentrations. It was observed that drug composites with higher drug concentration exhibited higher drug transport. Swelling and crosslinking played a crucial role in regulating the drug transport. Further, viability assay suggested biocompatibility of these matrices in vitro. Gel in vitro cell compatibility using live dead assay evaluated with AH-927 cell line indicated normal cell proliferation without any harmful effect and thus suggesting appropriateness of crosslinked composites as potential drug carrier.
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Dumitriu, Raluca Petronela, Daniela Pamfil, Manuela Tatiana Nistor, and Cornelia Vasile. "Stimuli Responsive Matrices for Medical Applications." Key Engineering Materials 638 (March 2015): 249–54. http://dx.doi.org/10.4028/www.scientific.net/kem.638.249.

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Different types of stimuli responsive polymers that respond with a property change to a variation in the environmental conditions are an attractive class of materials for advanced applications in biomedical or pharmaceutical fields. Three types of responsive biocompatible and biodegradable polymer matrices are presented as potential biomaterials for medical application as carriers for various drugs and tissue engineering substitutes. Hybrid hydrogels based on collagen/ N-isopropyl acrylamide containing montmorillonite nanoparticles are promising materials for tissue engineering and also as carriers for norfloxacin, a chemotherapeutic antibacterial agent. Semi-interpenetrated hydrogels based either on substituted anhydride modified collagen and 2-hydroxyethyl methacrylate or on alginate and poly (N-isopropylacrylamide) were tested as matrices for the controlled delivery of bisoprolol fumarate, an antihypertensive drug and respectively of ketoprofen, a non-steroidal anti-inflammatory drug.
29

Ouazib, Farid, Naima Bouslah Mokhnachi, Nabila Haddadine, and Regis Barille. "Role of polymer/polymer and polymer/drug specific interactions in drug delivery systems." Journal of Polymer Engineering 39, no. 6 (July 26, 2019): 534–44. http://dx.doi.org/10.1515/polyeng-2018-0403.

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Abstract Drug delivery systems based upon the blending of Arabic gum and poly(N-vinylpyrrolidone) (AG/PVP) were prepared for the controlled release of acebutolol (Acb) hydrochloride. The prepared blends containing Acb were characterized using different techniques. The presence of physical interactions between the drug and polymer matrices was observed with Fourier-transform infrared spectroscopy. These interactions resulted in the transition of the drug from a crystalline to an amorphous state into the polymeric matrices, as demonstrated by differential scanning calorimetry and X-ray diffraction analysis. The thermogravimetric analysis study confirmed the presence of these interactions, which had a stabilizing effect on the drug against both thermal degradation and crystallinity. The in vitro release of Acb from the AG/PVP polymer system was investigated. Each drug-loaded system was used in a tablet formulation. Moreover, an in vitro dissolution study was carried out in three different dissolution media, and comparison of the dissolution profiles of the different dosage forms revealed that the polymer blend matrix had a better release-retarding efficiency. To better understand the release mechanism, the dissolution data were fitted to various release kinetic models.
30

Aguilar-de-Leyva, Ángela, Vicente Linares, Marta Casas, and Isidoro Caraballo. "3D Printed Drug Delivery Systems Based on Natural Products." Pharmaceutics 12, no. 7 (July 3, 2020): 620. http://dx.doi.org/10.3390/pharmaceutics12070620.

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.
31

Ramachandran, Sivakumar, and Yihua Bruce Yu. "Peptide-Based Viscoelastic Matrices for Drug Delivery and Tissue Repair." BioDrugs 20, no. 5 (2006): 263–69. http://dx.doi.org/10.2165/00063030-200620050-00001.

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32

Giunchedi, Paolo, Elisabetta Gavini, Mario Domenico Luigi Moretti, and Gerolamo Pirisino. "Evaluation of alginate compressed matrices as prolonged drug delivery systems." AAPS PharmSciTech 1, no. 3 (September 2000): 31–36. http://dx.doi.org/10.1208/pt010319.

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33

Jiang, H. "Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery." Biomaterials 23, no. 11 (June 2002): 2345–51. http://dx.doi.org/10.1016/s0142-9612(01)00368-4.

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Prabaharan, M., R. L. Reis, and J. F. Mano. "Carboxymethyl chitosan-graft-phosphatidylethanolamine: Amphiphilic matrices for controlled drug delivery." Reactive and Functional Polymers 67, no. 1 (January 2007): 43–52. http://dx.doi.org/10.1016/j.reactfunctpolym.2006.09.001.

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Jayakrishnan, A., and S. R. Jameela. "Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices." Biomaterials 17, no. 5 (January 1996): 471–84. http://dx.doi.org/10.1016/0142-9612(96)82721-9.

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Benyerbah, Nassim, Pompilia Ispas-Szabo, Khalil Sakeer, Daniel Chapdelaine, and Mircea Alexandru Mateescu. "Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery." Pharmaceutics 11, no. 6 (June 1, 2019): 253. http://dx.doi.org/10.3390/pharmaceutics11060253.

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The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability. Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying trimethylaminehydroxypropyl (TMA) cationic groups and carboxymethyl (CM) anionic groups was obtained in one-step synthesis in aqueous media. Trimethylaminestarch (TMAS) and carboxymethylstarch (CMS) powders were also synthesized separately and then homogenized at equal proportions in liquid phase for co-processing by spray drying (SD) to obtain polyelectrolytic complexes TMAS-CMS (SD). Similarly, equal amounts of TMAS and CMS powders were dry mixed (DM) to obtain TMAS:CMS (DM). Monolithic tablets were obtained by direct compression of excipient/API mixes with 60% or 80% drug loads. The in vitro dissolution tests showed that ampholytic (TMACMS) and co-processed TMAS-CMS (SD) with selected tracers (one from each class of Biopharmaceutical Classification System (BCS)), were able to control the release even at very high loading (80%). The presence of opposite charges located at adequate distances may impact the polymeric chain organisation, their self-assembling, and implicitly the control of drug release. In conclusion, irrespective of preparation procedure, ampholytic and polyelectrolytic starch materials exhibited similar behaviours. Electrostatic interactions generated polymeric matrices conferring good mechanical features of tablets even at high drug loading.
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Sinha, V. R., and Rachna Kumria. "Polysaccharide Matrices for Microbially Triggered Drug Delivery to the Colon." Drug Development and Industrial Pharmacy 30, no. 2 (January 2004): 143–50. http://dx.doi.org/10.1081/ddc-120028709.

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Kretlow, James D., Leda Klouda, and Antonios G. Mikos. "Injectable matrices and scaffolds for drug delivery in tissue engineering." Advanced Drug Delivery Reviews 59, no. 4-5 (May 2007): 263–73. http://dx.doi.org/10.1016/j.addr.2007.03.013.

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Zhang, Ge, and Laura J. Suggs. "Matrices and scaffolds for drug delivery in vascular tissue engineering." Advanced Drug Delivery Reviews 59, no. 4-5 (May 2007): 360–73. http://dx.doi.org/10.1016/j.addr.2007.03.018.

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González, Zoilo, Ana Ferrandez-Montero, and Juan Domínguez-Robles. "Recent Advances in Polymers as Matrices for Drug Delivery Applications." Pharmaceuticals 16, no. 12 (December 1, 2023): 1674. http://dx.doi.org/10.3390/ph16121674.

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Ngwuluka, Ndidi C., Yahya E. Choonara, Girish Modi, Lisa C. du Toit, Pradeep Kumar, Leith Meyer, Tracy Snyman, and Viness Pillay. "Ex Vivo and In Vivo Characterization of Interpolymeric Blend/Nanoenabled Gastroretentive Levodopa Delivery Systems." Parkinson's Disease 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/7818123.

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One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNETand IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal fluid (CSF), and urine samples. Histopathology and cytotoxicity testing were also undertaken. The pharmacokinetic parameters indicated that levodopa was liberated from the drug delivery systems, absorbed, widely distributed, metabolized, and excreted.Cmaxwere 372.37, 257.02, and 461.28 ng/mL and MRT were 15.36, 14.98, and 13.30 for Madopar HBS capsules,PXLNET, and IPB, respectively. In addition, X-ray imaging indicated that the gastroretentive systems have the potential to reside in the stomach for 7 hours. There was strong in vitro-in vivo correlation for all formulations withr2values of 0.906, 0.935, and 0.945 for Madopar HBS capsules,PXLNET, and IPB, respectively. Consequently,PXLNETand IPB matrices have pertinent potential as gastroretentive systems for narrow absorption window drugs (e.g., L-dopa) and, in this application specifically, enhanced the central nervous system and/or systemic bioavailability of such drugs.
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He, Chuanglong, Wei Nie, and Wei Feng. "Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering." J. Mater. Chem. B 2, no. 45 (2014): 7828–48. http://dx.doi.org/10.1039/c4tb01464b.

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Anjali, Bagmar, and Tikariya Komal. "SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: AN OVERVIEW." International Journal of Pharmaceutical Sciences and Medicine 6, no. 9 (September 30, 2021): 79–87. http://dx.doi.org/10.47760/ijpsm.2021.v06i09.006.

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Oral delivery of drugs is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc. Sustained release constitutes are the dosage form that provides medication over an extended time or denotes that the system is able to provide some actual therapeutic control whether this is of a temporal nature, spatial nature or both. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Matrix tablets are the type of controlled drug delivery systems, which release the drug in continuous manner by dissolution controlled as well as diffusion controlled mechanisms. To control the release of the drugs, which are having different solubility properties, the drug is dispersed in swellable hydrophilic substances, an insoluble matrix of rigid non swellable hydrophobic materials or plastic materials. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.
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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (January 6, 2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controlled release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. There are several advantages of matrix devices including improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the drug, increased safety margin of a potent drug. This review aims on the discussion of different materials used to prepare matrix tablets, different types of matrix tablets and the drug release mechanism from the matrices.
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Procopio, Anna, Elena Lagreca, Rezvan Jamaledin, Sara La Manna, Brunella Corrado, Concetta Di Natale, and Valentina Onesto. "Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches)." Pharmaceutics 14, no. 4 (April 15, 2022): 872. http://dx.doi.org/10.3390/pharmaceutics14040872.

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The study of novel drug delivery systems represents one of the frontiers of the biomedical research area. Multi-disciplinary scientific approaches combining traditional or engineered technologies are used to provide major advances in improving drug bioavailability, rate of release, cell/tissue specificity and therapeutic index. Biodegradable and bio-absorbable polymers are usually the building blocks of these systems, and their copolymers are employed to create delivery components. For example, poly (lactic acid) or poly (glycolic acid) are often used as bricks for the production drug-based delivery systems as polymeric microparticles (MPs) or micron-scale needles. To avoid time-consuming empirical approaches for the optimization of these formulations, in silico-supported models have been developed. These methods can predict and tune the release of different drugs starting from designed combinations. Starting from these considerations, this review has the aim of investigating recent approaches to the production of polymeric carriers and the combination of in silico and experimental methods as promising platforms in the biomedical field.
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Berton, Paula, and Julia L. Shamshina. "Ionic Liquids as Tools to Incorporate Pharmaceutical Ingredients into Biopolymer-Based Drug Delivery Systems." Pharmaceuticals 16, no. 2 (February 11, 2023): 272. http://dx.doi.org/10.3390/ph16020272.

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This mini-review focuses on the various roles that ionic liquids play in the development and applications of biopolymer-based drug delivery systems (DDSs). Biopolymers are particularly attractive as drug delivery matrices due to their biocompatibility, low immunogenicity, biodegradability, and strength, whereas ILs can assist the formation of drug delivery carriers as 1. dopants to control drug release rate; 2. anchoring agents to incorporate APIs into biopolymeric materials; 3. actives (in the form of API-ILs) for controlled release; or 4. a matrix preparation media.
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Oliveira, Carlos B. P., Valéria Gomes, Paula M. T. Ferreira, José A. Martins, and Peter J. Jervis. "Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances." Gels 8, no. 11 (November 1, 2022): 706. http://dx.doi.org/10.3390/gels8110706.

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Supramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules. Targeted and selective drug administration is often preferential to systemic drug delivery, as it can allow reduced doses and can avoid the toxicity and side-effects caused by off-target binding. New discoveries are continually being reported in this rapidly developing field. In this review, we report the latest developments in supramolecular peptide-based hydrogels for drug delivery, focusing primarily on discoveries that have been reported in the last four years (2018–present). We address clinical points, such as peptide self-assembly and drug release, mechanical properties in drug delivery, peptide functionalization, bioadhesive properties and drug delivery enhancement strategies, drug release profiles, and different hydrogel matrices for anticancer drug loading and release.
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Anghel, Narcis, Iuliana Spiridon, Maria-Valentina Dinu, Stelian Vlad, and Mihaela Pertea. "Xanthan–Polyurethane Conjugates: An Efficient Approach for Drug Delivery." Polymers 16, no. 12 (June 19, 2024): 1734. http://dx.doi.org/10.3390/polym16121734.

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The antifungal agent, ketoconazole, and the anti-inflammatory drug, piroxicam, were incorporated into matrices of xanthan or oleic acid-esterified xanthan (Xn) and polyurethane (PU), to develop topical drug delivery systems. Compared to matrices without bioactive compounds, which only showed a nominal compressive stress of 32.18 kPa (sample xanthan–polyurethane) at a strain of 71.26%, the compressive resilience of the biomaterials increased to nearly 50.04 kPa (sample xanthan–polyurethane–ketoconazole) at a strain of 71.34%. The compressive strength decreased to around 30.67 kPa upon encapsulating a second drug within the xanthan–polyurethane framework (sample xanthan–polyurethane–piroxicam/ketoconazole), while the peak sustainable strain increased to 87.21%. The Weibull model provided the most suitable fit for the drug release kinetics. Unlike the materials based on xanthan–polyurethane, those made with oleic acid-esterified xanthan–polyurethane released the active ingredients more slowly (the release rate constant showed lower values). All the materials demonstrated antimicrobial effectiveness. Furthermore, a higher volume of piroxicam was released from oleic acid-esterified xanthan–polyurethane–piroxicam (64%) as compared to xanthan–polyurethane–piroxicam (44%). Considering these results, materials that include polyurethane and either modified or unmodified xanthan showed promise as topical drug delivery systems for releasing piroxicam and ketoconazole.
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D.Sondari, E. Hermiati, R. A. Ermawar, D. A. Pramasari, R. S. Ningrum, A. Muawanah, W. K. Restu, M. Septiyanti, and R. Suwarda. "EVALUATION OF CROSS-LINKED CASSAVA STARCH MICROSPHERES FOR DRUG DELIVERY MATRICES APPLICATION." RASAYAN Journal of Chemistry, Special Issue (2022): 110–17. http://dx.doi.org/10.31788/rjc.2022.1558139.

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The preparation of cross-linked cassava starch microspheres (CCSM) using catalyst sodium chloride and cross-linker sodium trimetaphosphate as drug delivery matrices has been studied. The CCSM's functional groups, freeze-thaw stability, swelling power, solubility, and gelatinization capabilities have been evaluated. The morphological structure, drug loading, and particle size of the AA encapsulation were also investigated. The water solubility and swelling degree increased after the modification via cross-linking, and then the morphology exhibited bell-shaped granules and a smooth, rounded surface. The drug delivery was analyzed using three dissolution mediums: 0.1 M of HCl, buffered saline phosphate (PBS pH of 7.4), and NaCl solution (9%). The PBS solvent resulted in a much better performance in drug delivery. The loading capacity, encapsulation efficiency, and release rate after 150 min of the AA were 31.490.20%, 89.840.23%, and 81.580.10%, respectively.
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Srivastava, Abhishek, and Anjali Prajapati. "Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications." Asian Biomedicine 14, no. 6 (December 1, 2020): 217–42. http://dx.doi.org/10.1515/abm-2020-0032.

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Abstract The inherent properties of albumin facilitate its effective use as a raw material to prepare a nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility, and extended half-life of albumin nanoparticles, a number of drugs have been incorporated in albumin matrices in recent years. Furthermore, its ability to be conjugated to various receptor ligands makes albumin an ideal candidate for the increased delivery of drugs to specific sites. The present review provides an in-depth discussion of production strategies for the preparation of albumin and conjugated albumin nanoparticles and for the targeting of these formulations to specific organs and cancer cells. This review also provides insights into drug loading, release patterns, and cytotoxicity of various drug-loaded albumin nanoparticles.
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