Academic literature on the topic 'Drug delivery devices'

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Journal articles on the topic "Drug delivery devices"

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Tony, Sara M., and Mohamed EA Abdelrahim. "Inhalation Devices and Pulmonary Drug Delivery." Journal of Clinical and Nursing Research 6, no. 3 (May 12, 2022): 54–72. http://dx.doi.org/10.26689/jcnr.v6i3.3908.

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Inhaled drug delivery is mainly used to treat pulmonary airway disorders by transporting the drug directly to its targeted location for action. This decreases the dose required to exert a therapeutic effect and minimizes any potential adverse effects. Direct drug delivery to air passages facilitates a faster onset of action; it also minimizes irritation to the stomach, which frequently occurs with oral medications, and prevents the exposure of drugs to pre-systemic metabolism that takes place in the intestine and liver. In addition to that, the lung is regarded as a route for transporting medications throughout the entire body’s blood circulation. The type of medication and the device used to deliver it are both important elements in carrying the drug to its target in the lungs. Different types of inhalation methods are used in inhaled delivery. They differ in the dose delivered, inhalation technique, and other factors. This paper will discuss these factors in more detail.
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Hafsa P V and Vidya Viswanad. "Pulmonary drug delivery-Determining attributes." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 21, 2020): 3819–27. http://dx.doi.org/10.26452/ijrps.v11i3.2556.

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Pulmonary diseases are one of the significant conditions and influence the lifestyle for a majority of the population in today’s world. From ancient times, inhalational drug delivery is being utilised to target the lungs for the management and treatment of pulmonary diseases with reduced side effects. Factors like the physiology of the respiratory system, selection of devices, particle characteristics, and formulation characteristics affect the efficiency of inhalational drug delivery. The precise usage of the inhaler device is indispensable for the efficient delivery of drugs. The characteristic particle impacts the region of drug deposition and in turn influences drug dissolution. Drug dissolution is also affected by the physiological aspect of the respiratory tract, which is concerned primarily in disease states. Formulation type and characteristics decide the release mechanism and influences the inhalational pattern. Liposomes, nanoparticles, microparticles, micelles, dendrimers, etc. can be utilised for passive and active targeting of drugs to the lungs. Inhalational drug delivery can be harnessed to deliver therapeutic agents to systemic circulation for diseases apart from pulmonary diseases. The inhalational drug delivery techniques and devices are being continuously researched upon and reworked to acquire better drug loading with minor loss during drug delivery. The review focuses on the significance and factors associated with pulmonary drug delivery.
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Ahmed, M. H., T. Naegele, S. Hilton, and G. Malliaras. "P07.05.A Implantable electrophoretic devices for local treatment of inoperable brain tumours." Neuro-Oncology 24, Supplement_2 (September 1, 2022): ii40. http://dx.doi.org/10.1093/neuonc/noac174.137.

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Abstract Background Glioblastoma (GBM) is the most malignant primary brain tumour in adults, with a median overall survival of fewer than 18 months after initial diagnosis. For over five decades, research has been focused on developing new anticancer therapies for GBM, including anti-neoplastic agents, molecular targeted drugs, immunotherapeutic approaches, and angiogenesis inhibiting compounds; however, the prognosis of patients has hardly improved and temozolomide remains the only chemotherapy shown to improve patient survival in randomized clinical trials. A fundamental limitation of the success of chemotherapy in brain cancer therapies is the blood-brain barrier which significantly reduces the concentration of chemotherapeutic agents delivered into a tumour. Material and Methods Therapeutic strategies that control drug release spatially and temporally represent a significant step forward in terms of reducing side effects and improving treatment efficacy and will thus have a significant clinical impact. Electrophoretic drug delivery devices, which use electric fields to enhance drug transport, represent one such strategy. Results Here, we present an implantable device that enables highly spatially selective delivery of charged drug molecules directly into brain tumours. Our device combines a microfluidic system for drug transport with embedded electrodes which enable electrophoretic transport of drug molecules into the target tissue. This allows delivery of chemotherapeutic agents without transport of bulk solvent preventing issues arising from intracranial pressure gradients. We have shown that the device can be implanted safely without any limitation. We have tested the device's capabilities to deliver a wide range of small, medium, and large chemotherapeutic agents without limitations. Currently, we are investigating the delivery of cisplatin in GBM-bearing mice. Conclusion While electrophoretic drug delivery was first described in the early 20th century and has been used since primarily for transdermal drug delivery, we believe that our approach is one of the first times this has been demonstrated for brain cancer therapy.
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Lasserre, Annie, and Praphulla K. Bajpai. "Ceramic Drug-Delivery Devices." Critical Reviews™ in Therapeutic Drug Carrier Systems 15, no. 1 (1998): 56. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v15.i1.10.

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Lilley, Linda L., and Robert Guanci. "Using Drug Delivery Devices." American Journal of Nursing 96, no. 10 (October 1996): 14. http://dx.doi.org/10.1097/00000446-199610000-00009.

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Ledger, Philip W., and Kirstin C. Nichols. "Transdermal drug delivery devices." Clinics in Dermatology 7, no. 3 (July 1989): 25–31. http://dx.doi.org/10.1016/0738-081x(89)90004-7.

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Hilt, J. Zachary, and Nicholas A. Peppas. "Microfabricated drug delivery devices." International Journal of Pharmaceutics 306, no. 1-2 (December 2005): 15–23. http://dx.doi.org/10.1016/j.ijpharm.2005.09.022.

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Krause-Heuer, Anwen M., Maxine P. Grant, Nikita Orkey, and Janice R. Aldrich-Wright. "Drug Delivery Devices and Targeting Agents for Platinum(II) Anticancer Complexes." Australian Journal of Chemistry 61, no. 9 (2008): 675. http://dx.doi.org/10.1071/ch08157.

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An ideal platinum-based delivery device would be one that selectively targets cancerous cells, can be systemically delivered, and is non-toxic to normal cells. It would be beneficial to provide drug delivery devices for platinum-based anticancer agents that exhibit high drug transport capacity, good water solubility, stability during storage, reduced toxicity, and enhanced anticancer activity in vivo. However, the challenges for developing drug delivery devices include carrier stability in vivo, the method by which extracellular or intracellular drug release is achieved, overcoming the various mechanisms of cell resistance to drugs, controlled drug release to cancer cells, and platinum drug bioavailability. There are many potential candidates under investigation including cucurbit[n]urils, cyclodextrins, calix[n]arenes, and dendrimers, with the most promising being those that are synthetically adaptable enough to attach to targeting agents.
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Lin, Michael M., Joseph B. Ciolino, and Louis R. Pasquale. "Novel Glaucoma Drug Delivery Devices." International Ophthalmology Clinics 57, no. 4 (2017): 57–71. http://dx.doi.org/10.1097/iio.0000000000000190.

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Nuxoll, E., and R. Siegel. "BioMEMS devices for drug delivery." IEEE Engineering in Medicine and Biology Magazine 28, no. 1 (January 2009): 31–39. http://dx.doi.org/10.1109/memb.2008.931014.

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Dissertations / Theses on the topic "Drug delivery devices"

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Dickers, Kirsten. "Drug delivery devices from polyglycolide." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415267.

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Guan, Jingjiao. "Microfabricated particulate devices for drug delivery." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118247862.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xxiii, 163 p.; also includes graphics. Includes bibliographical references (p. 118-123). Available online via OhioLINK's ETD Center
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Lei, Wang S. "Fabrication of drug delivery MEMS devices." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/58271.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.
"May 2007." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 19).
There is considerable amount of interest in the immediate treatment of personnel involved in high risk situations on the battlefield. A novel approach to drug delivery on the battlefield based on MEMS technology is discussed. By combining three separately fabricated layers, a single implantable drug delivery device capable of delivering up to 100 mm3 of a vasopressin solution was developed. In vitro release of vasopressin was observed and the I-V response of the bubble generator was characterized. Results show that the voltage at the time of release is ~11V while the current is ~0.35A, giving a power output of 3.79W. The time to total release of the drug was less than 2 minutes.
by Wang Lei.
S.B.
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Sinha, Piyush M. "Nanoengineered implantable devices for controlled drug delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1115138930.

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Sinha, Piyush Mohan. "Nanoengineered implantable devices for controlled drug delivery." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1115138930.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xxii, 220 p.; also includes graphics (some col.). Includes bibliographical references (p. 202-220). Available online via OhioLINK's ETD Center.
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Jiang, Ninghao. "Ocular drug delivery using microneedles." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19796.

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Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2007.
Committee Chair: Prausnitz, Mark R.; Committee Member: Allen, Mark; Committee Member: Edelhauser, Henry; Committee Member: Geroski, Dayle; Committee Member: Nickerson, John; Committee Member: Sambanis, Athanassios.
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Ohbi, Daljit Singh. "Novel Elastomer Compositions for Medical Drug Delivery Devices." Thesis, University of Bolton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494268.

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Campbell, Christopher. "Poly(lactide-co-glycolide) devices for drug delivery." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500691.

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Ovarian cancer is one of the five most common causes of cancer death in women in the USA and UK. It is usually diagnosed when it is well established beyond the ovary in the peritoneum. Intravenous injection of cisplatin is a common palliative therapy for ovarian cancer patients. Intraperitoneal therapy has been shown to improve survival for patients. Poly(lactide-co-glycolide) (PLGA) is a biodegradable polyester which has been proven safe for medical implantation. PLGA microspheres or fibres have been considered in this work as depots for delivering intraperitoneal cisplatin directly to the tumour site. The aims of this work were (1) to develop microsphere depot formulations with improved drug release profiles compared to previous work; (2) Novel cisplatin containing solid and hollow fibres were to be developed and investigated as alternative structures for depot devices; (3) The drug release profiles were to be examined using mathematical models to allow rational comparison of the devices. It was found that cisplatin containing PLGA 65:35 solid and hollow fibres represent a novel, reproducible formulation for encapsulating higher amounts of cisplatin for an equivalent mass of excipient than other polymer formulations. The fibres developed in this study were able to maintain elevated concentrations of unbound cisplatin in the presence of a biological matrix for approximately 100 hours in vitro.
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Chu, Leonard Yi. "Dissolving microneedles for cutaneous drug and vaccine delivery." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37177.

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Currently, biopharmaceuticals including vaccines, proteins, and DNA are delivered almost exclusively through the parenteral route using hypodermic needles. However, injection by hypodermic needles generates pain and causes bleeding. Disposal of these needles also produces biohazardous sharp waste. An alternative delivery tool called microneedles may solve these issues. Microneedles are micron-size needles that deliver drugs or biopharmaceuticals into skin by creating tiny channels in the skin. This thesis focuses on dissolving microneedles in which the needle tips dissolve and release the encapsulated drug or vaccine upon insertion. The project aimed to (i) design and optimize dissolving microneedles for efficient drug and vaccine delivery to the skin, (ii) maintain vaccine stability over long-term storage, and (iii) immunize animals using vaccine encapsulated microneedles. The results showed that influenza vaccine encapsulated in microneedles was more thermally stable than unprocessed vaccine solution over prolonged periods of storage time. In addition, mice immunized with microneedles containing influenza vaccine offered full protection against lethal influenza virus infection. As a result, we envision the newly developed dissolving microneedle system can be a safe, patient compliant, easy to-use and self-administered method for rapid drug and vaccine delivery to the skin.
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Mualem-Burstein, Odelia Wheatley Margaret A. "Drug loading onto polymeric contrast agents for ultrasound drug delivery /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2811.

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Books on the topic "Drug delivery devices"

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Prokopovich, Polina. Inhaler devices: Fundamentals, design and drug delivery. Cambridge: Woodhead Publishing Limited, 2013.

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Shachar, Josh Yehoshua. Frontiers in drug delivery: Pharmaco-kinesis collected patents. [Los Angeles, CA]: Pharmaco-Kinesis Corporation, 2010.

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Rebecca, White. Handbook of drug administration via enteral feeding tubes. London, UK: (PhP), Pharmaceutical Press, 2015.

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Biomedical materials and diagnostic devices. Hoboken, N.J: John Wiley & Sons, 2012.

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Vicky, Bradnam, ed. Handbook of drug administration via enteral feeding tubes. London: Pharmaceutical Press, 2008.

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Seminar and Meeting on Ceramics, Cells, and Tissues (6th 2000 Faenza, Italy). Ceramics, cells, and tissues: Drugs delivery systems. Faenza: Consiglio nazionale delle ricerche, 2000.

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Battjes, Robert. Needle sharing among intravenous drug abusers: National and international perspectives. Edited by Pickens Roy W and National Institute on Drug Abuse. Rockville, MD: U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1988.

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Battjes, Robert. Needle sharing among intravenous drug abusers: National and international perspectives. Edited by Pickens Roy W and National Institute on Drug Abuse. Rockville, MD: U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1988.

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Seminar, and meeting on Ceramics Cells and Tissues (6th 2000 Banca di Romagna). 6th Seminar and Meeting on--Ceramics, Cells and Tissues: Drugs delivery systems held at the Congress Hall of Banca di Romagna, Faenza, March 9-11, 2000. Faenza, Italy: Istituto di ricerche tecnologiche per la ceramica del CNR, 2000.

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DeSimone, Jeff. Determinants of drug injection behavior: Economic factors, HIV injection risk and needle exchange programs. Cambridge, Mass: National Bureau of Economic Research, 2002.

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Book chapters on the topic "Drug delivery devices"

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Yasukawa, Tsutomu, and Yuichiro Ogura. "Medical Devices for the Treatment of Eye Diseases." In Drug Delivery, 469–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00477-3_16.

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Simpson, Iain, James Blakemore, and Chung Chow Chan. "Overview of Drug Delivery Devices." In Therapeutic Delivery Solutions, 105–34. Hoboken, NJ: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118903681.ch4.

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Brown, Marc B., Matthew J. Traynor, Gary P. Martin, and Franklin K. Akomeah. "Transdermal Drug Delivery Systems: Skin Perturbation Devices." In Drug Delivery Systems, 119–39. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-210-6_5.

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Lowman, Anthony M. "Biomaterials in Drug Delivery." In Biomedical Devices and Their Applications, 1–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-06108-4_1.

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Juarez-Martinez, Gabriela, Alessandro Chiolerio, Paolo Allia, Martino Poggio, Christian L. Degen, Li Zhang, Bradley J. Nelson, et al. "MEMS-Based Drug Delivery Devices." In Encyclopedia of Nanotechnology, 1368. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100401.

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Rubin, Bruce K., and James B. Fink. "Drug Delivery Devices and Propellants." In Allergy Frontiers: Therapy and Prevention, 245–58. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-99362-9_15.

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Lastow, Orest. "Future Patient Requirements on Inhalation Devices: The Balance between Patient, Commercial, Regulatory and Technical Requirements." In Pulmonary Drug Delivery, 339–52. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118799536.ch16.

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Thompson, Ian, and Jakob Lange. "Pen and Autoinjector Drug Delivery Devices." In Sterile Product Development, 331–56. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7978-9_13.

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Agotegaray, Mariela A., and Verónica L. Lassalle. "Magnetic Nanoparticles as Drug Delivery Devices." In SpringerBriefs in Molecular Science, 9–26. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50158-1_2.

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Kim, Ki Su, Ho Sang Jung, Hyunsik Choi, Songeun Beack, Hyemin Kim, Jong Hwan Mun, Myeong Hwan Shin, et al. "Smart Drug Delivery Devices and Implants." In Emerging Areas in Bioengineering, 593–605. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783527803293.ch33.

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Conference papers on the topic "Drug delivery devices"

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Guy, Owen J., Huma Ashraf, Gareth Blayney, Chris Bolton, Connie Eng, Olivia Howells, Kerry Roberts, and Sanjiv Sharma. "Microneedle Devices for Drug Delivery." In The 3rd World Congress on Recent Advances in Nanotechnology. Avestia Publishing, 2018. http://dx.doi.org/10.11159/nddte18.2.

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"Drug Delivery System." In 2004 2nd IEEE/EMBS International Summer School on Medical Devices and Biosensors. IEEE, 2004. http://dx.doi.org/10.1109/issmd.2004.1689583.

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Quispe, Rodrigo, Jorge A. Trevino, Faizan Khan, and Vera Novak. "Strategies for nose-to-brain drug delivery." In the 8th International Workshop on Innovative Simulation for Healthcare. CAL-TEK srl, 2019. http://dx.doi.org/10.46354/i3m.2019.iwish.017.

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"Intranasal drug administration is an effective method that has shown promise for delivering drugs directly to the brain. This approach is associated with many challenges, and efficacy in bypassing blood-brain barrier (BBB) is debated. This review describes the pathways of nose-to-brain drug delivery, physicochemical drug properties that influence drug uptake through the nasal epithelium, physiological barriers, methods to enhance nose-to-brain absorption, drug bioavailability and biodistribution, and intranasal devices for nose-to-brain drug delivery. The mechanism of each device is described and supporting evidence from clinical trials is presented. This paper summarizes strategies involved in nose-to-brain drug delivery and provides evidence of potential efficacy of nose-braindelivery from clinical trials."
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Divetia, Asheesh, Nolan Yoshimura, Guann-Pynn Li, Baruch D. Kuppermann, and Mark Bachman. "Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38054.

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Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer upon contact with water and the resulting pressure generated is used as an actuation mechanism to release drugs from each reservoir. The programmable release of the drug from the device is achieved by controlling the diffusion rate of water from the surrounding environment into each reservoir. The drug is released from the reservoir when the swellable polymer absorbs water from the environment and generates enough pressure to break an overlying rupturable membrane. We have demonstrated that controlled and pulsatile drug delivery can be achieved using this delivery device, without any external power or control.
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Mingjun Zhang, Tzyh-Jong Tarn, and Ning Xi. "Micro/nano-devices for controlled drug delivery." In IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004. IEEE, 2004. http://dx.doi.org/10.1109/robot.2004.1308128.

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Proctor, Christopher. "Materials and devices for electronic drug delivery." In nanoGe Spring Meeting 2022. València: Fundació Scito, 2022. http://dx.doi.org/10.29363/nanoge.nsm.2022.128.

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Fischer, Kathleen, Sarah Tao, Hugh Daniels, Esther Li, and Tejal Desai. "Silicon nanowires for bioadhesive drug delivery." In 2008 IEEE International Electron Devices Meeting (IEDM). IEEE, 2008. http://dx.doi.org/10.1109/iedm.2008.4796686.

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Di Trani, N., A. Grattoni, and M. Ferrari. "Nanofluidics for cell and drug delivery." In 2017 IEEE International Electron Devices Meeting (IEDM). IEEE, 2017. http://dx.doi.org/10.1109/iedm.2017.8268529.

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Feng, Yu, Xiaole Chen, and Mingshi Yang. "An In Silico Investigation of a Lobe-Specific Targeted Pulmonary Drug Delivery Method." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6928.

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Nowadays, “personalized medicine” is starting to replace the current “one size fits all” approach. The goal is to have the right drug with the right dose for the right patient at the right time and location. Indeed, conventional pulmonary drug delivery devices still have poor efficiencies (<25%) for delivering drugs to the lung tumor sites. Major portions of the aggressive medicine deposit on healthy tissue, which causes severe side effects and induces extra health care expenses. Therefore, a new targeted pulmonary drug delivery method is proposed and evaluated using the Computational Fluid-Particle Dynamics (CFPD) method to achieve the lobe-specific delivery. By controlling the release position and velocity of the drug particles at the mouth inlet, drug deposition efficiency (DE) in a designated lobe can be increased up to 90%. Intersubject variability has also been investigated using the noninvasive in silico tool. Results indicate that the glottis constriction ratio is a key factor to influence the effectiveness of the purposed targeted drug delivery method. Although lobe-specific pulmonary drug delivery can be realized, the actuation flow rate must be lower than 2 L/min, and the glottis constriction ratio has a significant impact on the effectiveness of the targeting method. Also, a design idea using e-cigarette as the prototype is proposed as the next-generation inhaler to accommodate the operational flexibility restrictions.
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Ghahremani, Mohammadreza, Marjan Nabili, Sankara Mahesh, Ji Liu, David Belyea, Craig Geist, Vesna Zderic, and Mona Zaghloul. "Surface Acoustic Wave devices for ocular drug delivery." In 2010 IEEE Ultrasonics Symposium (IUS). IEEE, 2010. http://dx.doi.org/10.1109/ultsym.2010.5935970.

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Reports on the topic "Drug delivery devices"

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Riffle, Judy S. SEEDLING Proposal to Establish Pilot Data for a Consortium on Magnetic Nanoparticle Assemblies: A New Tool for Drug Delivery, Sensors and Electronic Devices. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada418026.

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