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Journal articles on the topic 'Drug Delivery Applications'

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Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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1

Mohanty, Swati. "Chitosan Dendrimer for Drug Delivery Applications." Journal of Advance Nanobiotechnology 2, no. 5 (October 30, 2018): 16–19. http://dx.doi.org/10.28921/jan.2018.02.28.

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2

T. Varkey, Jaya. "Peptides-Incorporated Nanoparticles for Imaging and Drug Delivery Applications." Journal of Pharmaceutical and Medicinal Chemistry 2, no. 2 (2016): 145–48. http://dx.doi.org/10.21088/jpmc.2395.6615.2216.4.

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3

Priya, V. Sri Vajra, Hare Krishna Roy, N. jyothi, and N. Lakshmi Prasanthi. "Polymers in Drug Delivery Technology, Types of Polymers and Applications." Scholars Academic Journal of Pharmacy 5, no. 7 (July 2016): 305–8. http://dx.doi.org/10.21276/sajp.2016.5.7.7.

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4

Ng, Jaryl Chen Koon, Daniel Wee Yee Toong, Valerie Ow, Su Yin Chaw, Hanwei Toh, Philip En Hou Wong, Subbu Venkatraman, et al. "Progress in drug-delivery systems in cardiovascular applications: stents, balloons and nanoencapsulation." Nanomedicine 17, no. 5 (February 2022): 325–47. http://dx.doi.org/10.2217/nnm-2021-0288.

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Drug-delivery systems in cardiovascular applications regularly include the use of drug-eluting stents and drug-coated balloons to ensure sufficient drug transfer and efficacy in the treatment of cardiovascular diseases. In addition to the delivery of antiproliferative drugs, the use of growth factors, genetic materials, hormones and signaling molecules has led to the development of different nanoencapsulation techniques for targeted drug delivery. The review will cover drug delivery and coating mechanisms in current drug-eluting stents and drug-coated balloons, novel innovations in drug-eluting stent technologies and drug encapsulation in nanocarriers for delivery in vascular diseases. Newer technologies and advances in nanoencapsulation techniques, such as the use of liposomes, nanogels and layer-by-layer coating to deliver therapeutics in the cardiovascular space, will be highlighted.
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5

Li, Wei, Jing Lin, Tianfu Wang, and Peng Huang. "Photo-triggered Drug Delivery Systems for Neuron-related Applications." Current Medicinal Chemistry 26, no. 8 (May 16, 2019): 1406–22. http://dx.doi.org/10.2174/0929867325666180622121801.

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The development of materials, chemistry and genetics has created a great number of systems for delivering antibiotics, neuropeptides or other drugs to neurons in neuroscience research, and has also provided important and powerful tools in neuron-related applications. Although these drug delivery systems can facilitate the advancement of neuroscience studies, they still have limited applications due to various drawbacks, such as difficulty in controlling delivery molecules or drugs to the target region, and trouble of releasing them in predictable manners. The combination of optics and drug delivery systems has great potentials to address these issues and deliver molecules or drugs to the nervous system with extraordinary spatiotemporal selectivity triggered by light. In this review, we will introduce the development of photo-triggered drug delivery systems in neuroscience research and their neuron-related applications including regulating neural activities, treating neural diseases and inducing nerve regenerations.
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6

Ramanujam, Ranjith, Balraj Sundaram, Ganesh Janarthanan, Elamparithi Devendran, Moorthy Venkadasalam, and M. C. John Milton. "Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review." Biosciences, Biotechnology Research Asia 15, no. 3 (September 25, 2018): 679–85. http://dx.doi.org/10.13005/bbra/2676.

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Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.
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7

Pentlavalli, Sreekanth, Sophie Coulter, and Garry Laverty. "Peptide Nanomaterials for Drug Delivery Applications." Current Protein & Peptide Science 21, no. 4 (April 29, 2020): 401–12. http://dx.doi.org/10.2174/1389203721666200101091834.

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Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.
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8

Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (September 28, 2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the drug in formulations was found to be intact and compatible with lipids used. Two optimized formulations containing cilostazol lecithin-cholesterol showed Korsemayer peppas model perfect zero order release and showed better sustained and controlled drug release. Lecithin-cholesterol nanocochleates prepared by external ionotropic trapping method was found to be better ionic cross linking of drug-lipids particles. Therefore, ionotropic cross-linked particles are promising carriers for oral controlled release dosage forms.
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9

Heggannavar, Geetha B., Divya Achari, Cristiana Fernandes, Geoffrey R. Mitchell, Pedro Morouço, and Mahadevappa Y. Kariduraganavar. "Smart Polymers in Drug Delivery Applications." Applied Mechanics and Materials 890 (April 2019): 324–39. http://dx.doi.org/10.4028/www.scientific.net/amm.890.324.

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The most important components of living cells such as carbohydrates, proteins and nucleic acids are the polymeric molecules. Nature utilizes polymers both as constructive elements and as a part of the complicated cell machinery of living things. The rapid advancement in biomedical research has led to many creative applications for biocompatible polymers. With the development of newer and more potent drugs, a parallel expansion in more sophisticated drug delivery systems becomes mandatory. Smart polymeric drug-delivery systems have the ability to respond to environmental changes and consequently, alter their properties reversibly enabling an efficient and safe drug delivery. This review comprehensively discusses various aspects of these polymers classified in different categories as per the type of stimulus.
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10

Antimisiaris, Sophia G. "Arsonoliposomes for drug delivery applications." Clinical Lipidology 4, no. 5 (October 2009): 663–75. http://dx.doi.org/10.2217/clp.09.42.

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11

Moreira, André Ferreira. "Nanomaterials in Drug Delivery Applications." Nanomaterials 12, no. 20 (October 12, 2022): 3565. http://dx.doi.org/10.3390/nano12203565.

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12

Ainbinder, D., D. Paolino, M. Fresta, and E. Touitou. "Drug Delivery Applications with Ethosomes." Journal of Biomedical Nanotechnology 6, no. 5 (October 1, 2010): 558–68. http://dx.doi.org/10.1166/jbn.2010.1152.

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13

BAILEY, S. "Local drug delivery: Current applications." Progress in Cardiovascular Diseases 40, no. 2 (September 1997): 183–204. http://dx.doi.org/10.1016/s0033-0620(97)80008-4.

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14

Chamundeeswari, Munusamy, John Jeslin, and Madan Lal Verma. "Nanocarriers for drug delivery applications." Environmental Chemistry Letters 17, no. 2 (November 21, 2018): 849–65. http://dx.doi.org/10.1007/s10311-018-00841-1.

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15

Vandervoort, Jo, and Annick Ludwig. "Ocular drug delivery: nanomedicine applications." Nanomedicine 2, no. 1 (February 2007): 11–21. http://dx.doi.org/10.2217/17435889.2.1.11.

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16

Erxleben, Andrea. "Cocrystal Applications in Drug Delivery." Pharmaceutics 12, no. 9 (September 1, 2020): 834. http://dx.doi.org/10.3390/pharmaceutics12090834.

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17

Walsh, Laura A., Jessica L. Allen, and Tejal A. Desai. "Nanotopography applications in drug delivery." Expert Opinion on Drug Delivery 12, no. 12 (October 29, 2015): 1823–27. http://dx.doi.org/10.1517/17425247.2015.1103734.

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18

Lin, Quanming, Guohua Jiang, and Kangkang Tong. "Dendrimers in Drug-Delivery Applications." Designed Monomers and Polymers 13, no. 4 (January 2010): 301–24. http://dx.doi.org/10.1163/138577210x509552.

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19

Cardinal, John R. "Controlled drug delivery: Veterinary applications." Journal of Controlled Release 2 (November 1985): 393–403. http://dx.doi.org/10.1016/0168-3659(85)90061-6.

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20

Joshi, Shailendra, Phillip M. Meyers, and Eugene Ornstein. "Intracarotid Delivery of Drugs." Anesthesiology 109, no. 3 (September 1, 2008): 543–64. http://dx.doi.org/10.1097/aln.0b013e318182c81b.

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The major efforts to selectively deliver drugs to the brain in the past decade have relied on smart molecular techniques to penetrate the blood-brain barrier, whereas intraarterial drug delivery has drawn relatively little attention. Meanwhile, rapid progress has been made in the field of endovascular surgery. Modern endovascular procedures can permit highly targeted drug delivery by the intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggest that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.
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21

Li, Jiayao, Yinan Liu, and Hend Abdelhakim. "Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy." Molecules 27, no. 6 (March 10, 2022): 1803. http://dx.doi.org/10.3390/molecules27061803.

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Cancer is one of the most serious health problems and the second leading cause of death worldwide, and with an ageing and growing population, problems related to cancer will continue. In the battle against cancer, many therapies and anticancer drugs have been developed. Chemotherapy and relevant drugs are widely used in clinical practice; however, their applications are always accompanied by severe side effects. In recent years, the drug delivery system has been improved by nanotechnology to reduce the adverse effects of the delivered drugs. Among the different candidates, core–sheath nanofibres prepared by coaxial electrospinning are outstanding due to their unique properties, including their large surface area, high encapsulation efficiency, good mechanical property, multidrug loading capacity, and ability to govern drug release kinetics. Therefore, encapsulating drugs in coaxial electrospun nanofibres is a desirable method for controlled and sustained drug release. This review summarises the drug delivery applications of coaxial electrospun nanofibres with different structures and drugs for various cancer treatments.
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22

S, Lakshmana Prabu. "A Typical Properties of Nanomaterials for Applications in Drug Delivery: A Review." Bioequivalence & Bioavailability International Journal 5, no. 2 (2021): 1–7. http://dx.doi.org/10.23880/beba-16000155.

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Developing a new drug molecule is an interdisciplinary research. A new drug molecule takes 10-14 years to develop with a 0.01% success rate. The developed new drug is administered as conventional or sustained release dosage forms. Among the conventional and sustained release dosage forms, sustained release form has many advantages. In the 21 st century, nanotechnology has become an innovative field and the nanomaterials/nanoparticles made by this technology had specific atypical properties. An extensive research interest among the researchers made a new revolution and its application almost in all the fields. This nanotechnology in medicinal profession especially in drug delivery has developed several products for the treatment and cure of many diseases. This article summarizes the different nanomaterials, its atypical properties and outlines the different methods of nanoparticle preparations for applications in drug delivery
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23

EZEGBE, CHEKWUBE, Ogechukwu Umeh, and Sabinus Ofoefule. "Drug Carriers." Journal of Current Biomedical Research 2, no. 1 (February 28, 2022): 77–105. http://dx.doi.org/10.54117/jcbr.v2i1.3.

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In recent years, there has been an exponential interest in the development of novel drug delivery systems using drug carriers. Drug carriers offer significant advantages over the conventional drug delivery systems in terms of high stability, high specificity, high drug loading capacity, controlled release of drug and ability to deliver both hydrophilic and hydrophobic drugs. As a result of their unique behaviors, drug carriers have a wide range of biomedical and industrial applications. Nanospheres are associated with a lot of benefits such as ease of administration to target sites, reduction in toxicity level and ease of passage via the capillary vessels. Hydrogel nanoparticles are useful in the treatment of inflammatory diseases, as bioresponsive hydrogels in drug delivery system and as a carrier in controlled drug delivery system. Carbon nanotubes have a large surface area which has the ability to adsorb or conjugate with a wide variety of therapeutic and diagnostic agents. They are useful in the areas of gene delivery, tissue regeneration and biosensor diagnosis. Liposomes are known to target a drug to a specific site. They entrap drugs which are released for subsequent absorption. They are used to achieve active targeting, increase efficacy and therapeutic index of drugs. Niosomes improve the solubility and oral bioavailability of poorly soluble drugs. They protect drugs from biological environment, increase the stability of entrapped drugs and they can easily reach the site of action. Aquasomes are nanoparticulate carriers that can be characterized for structural analysis. They preserve conformational integrity and biochemical stability of drugs. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. They contain phospholipids which could be in form of phosphatidyl choline (PC), hydrogenated PC, phosphatidic acid (PA), Phosphatidyl serine (PS) and phosphatidyl inositol (PI). Ethosomes are known to increase skin permeation of drugs, improve biological activity and pharmacodynamics profile of drugs. This review aims to emphasize the importance of drug carriers in drug delivery system, and applications of drug carriers in various areas of research, technology and treatment.
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24

Witika, Bwalya A., Kokoette E. Bassey, Patrick H. Demana, Xavier Siwe-Noundou, and Madan S. Poka. "Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications." International Journal of Molecular Sciences 23, no. 17 (August 26, 2022): 9668. http://dx.doi.org/10.3390/ijms23179668.

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Development of nanomaterials for drug delivery has received considerable attention due to their potential for achieving on-target delivery to the diseased area while the surrounding healthy tissue is spared. Safe and efficiently delivered payloads have always been a challenge in pharmaceutics. Niosomes are self-assembled vesicular nanocarriers formed by hydration of a non-ionic surfactant, cholesterol or other molecules that combine to form a versatile drug delivery system with a variety of applications ranging from topical delivery to targeted delivery. Niosomes have advantages similar to those of liposomes with regards to their ability to incorporate both hydrophilic and hydrophobic payloads. Moreover, niosomes have simple manufacturing methods, low production cost and exhibit extended stability, consequently overcoming the major drawbacks associated with liposomes. This review provides a comprehensive summary of niosomal research to date, including the types of niosomes and critical material attributes (CMA) and critical process parameters (CPP) of niosomes and their effects on the critical quality attributes (CQA) of the technology. Furthermore, physical characterisation techniques of niosomes are provided. The review then highlights recent applications of specialised niosomes in drug delivery. Finally, limitations and prospects for this technology are discussed.
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25

Sharma, Naveen, Ganesh Bhatt, and Preeti Kothiyal. "Gold Nanoparticles synthesis, properties, and forthcoming applications : A review." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (June 30, 2015): 13–27. http://dx.doi.org/10.30750/ijpbr.3.2.3.

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Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characteristics. AuNPs can be conjugated with ligands, imaging labels, therapeutic drugs and other functional moieties for site specific drug delivery application. In this present review we are discussing the synthesis, properties, and forthcoming applications of gold nanoparticle (AuNPs) which is the most studied among all other metallic-nanoparticles. Here our main focus is to explain the AuNPs application in cancer treatment. AuNPs provides non-toxic carrier system for pharmaceutical drug and gene delivery applications. Currently various anticancer drugs are available but these are cause the necrosis of cancerous cell as well as normal cells. AuNPs cause the necrosis of only cancer cells therefore we can utilize it as a delivery vehicle as well as anticancer agent
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26

Brahamdutt, Brahamdutt, Arun Arun, Pradeep Sangwan, Pritam Singh, Vikas Yadav, and Sandeep Kumar. "A Review about various Nanomaterials in Drug Delivery Systems and their Applications." International Journal of Research and Development in Pharmacy & Life Sciences 7, no. 3 (June 2018): 2969–81. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2018.7(3).2969-2981.

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27

Afzal, Obaid, Abdulmalik S. A. Altamimi, Muhammad Shahid Nadeem, Sami I. Alzarea, Waleed Hassan Almalki, Aqsa Tariq, Bismillah Mubeen, et al. "Nanoparticles in Drug Delivery: From History to Therapeutic Applications." Nanomaterials 12, no. 24 (December 19, 2022): 4494. http://dx.doi.org/10.3390/nano12244494.

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Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating nanocarriers. This paper reviews the various conventionally used and current used carriage system to deliver drugs. Due to numerous drawbacks of conventional DDSs, nanocarriers have gained immense interest. Nanocarriers like polymeric nanoparticles, mesoporous nanoparticles, nanomaterials, carbon nanotubes, dendrimers, liposomes, metallic nanoparticles, nanomedicine, and engineered nanomaterials are used as carriage systems for targeted delivery at specific sites of affected areas in the body. Nanomedicine has rapidly grown to treat certain diseases like brain cancer, lung cancer, breast cancer, cardiovascular diseases, and many others. These nanomedicines can improve drug bioavailability and drug absorption time, reduce release time, eliminate drug aggregation, and enhance drug solubility in the blood. Nanomedicine has introduced a new era for drug carriage by refining the therapeutic directories of the energetic pharmaceutical elements engineered within nanoparticles. In this context, the vital information on engineered nanoparticles was reviewed and conferred towards the role in drug carriage systems to treat many ailments. All these nanocarriers were tested in vitro and in vivo. In the coming years, nanomedicines can improve human health more effectively by adding more advanced techniques into the drug delivery system.
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28

Han, Yohan, Timothy W. Jones, Saugata Dutta, Yin Zhu, Xiaoyun Wang, S. Priya Narayanan, Susan C. Fagan, and Duo Zhang. "Overview and Update on Methods for Cargo Loading into Extracellular Vesicles." Processes 9, no. 2 (February 15, 2021): 356. http://dx.doi.org/10.3390/pr9020356.

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The enormous library of pharmaceutical compounds presents endless research avenues. However, several factors limit the therapeutic potential of these drugs, such as drug resistance, stability, off-target toxicity, and inadequate delivery to the site of action. Extracellular vesicles (EVs) are lipid bilayer-delimited particles and are naturally released from cells. Growing evidence shows that EVs have great potential to serve as effective drug carriers. Since EVs can not only transfer biological information, but also effectively deliver hydrophobic drugs into cells, the application of EVs as a novel drug delivery system has attracted considerable scientific interest. Recently, EVs loaded with siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, or therapeutic drugs show improved delivery efficiency and drug effect. In this review, we summarize the methods used for the cargo loading into EVs, including siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, and therapeutic drugs. Furthermore, we also include the recent advance in engineered EVs for drug delivery. Finally, both advantages and challenges of EVs as a new drug delivery system are discussed. Here, we encourage researchers to further develop convenient and reliable loading methods for the potential clinical applications of EVs as drug carriers in the future.
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29

Gupta, Ankita, Shaifali Dubey, and Mayuri Mishra. "Unique Structures, Properties and Applications of Dendrimers." Journal of Drug Delivery and Therapeutics 8, no. 6-s (December 15, 2018): 328–39. http://dx.doi.org/10.22270/jddt.v8i6-s.2083.

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Dendrimers are novel three dimensional, hyperbranched globular nano polymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index and excellent control over molecular structure afford dendrimers with ideal drug delivery ability through encapsulating drugs in their interior or covalently conjugating drugs on their surfaces. The adaptable surface functionalization ability enables covalent conjugation of various targeting molecules onto the surface of dendrimers, thereby allowing for generation of various multifunctional nanodevices for targeted drug delivery applications. Drug delivery researchers are especially enthusiastic about possible utility of dendrimers as drug delivery tool. However, to get the maximum benefits of these novel class macromolecules, a research by collaboration is very much essential. Finally, it is one of the youngest and exciting fields of polymer researches where all branches of science can take part and hence, deserves more intensive attention. Keywords: Dendrimers, Drug Delivery, Targeting, Dual Drug Loading, PAMAM
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30

Narayanaswamy, Radhika, and Vladimir P. Torchilin. "Hydrogels and Their Applications in Targeted Drug Delivery." Molecules 24, no. 3 (February 8, 2019): 603. http://dx.doi.org/10.3390/molecules24030603.

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Conventional drug delivery approaches are plagued by issues pertaining to systemic toxicity and repeated dosing. Hydrogels offer convenient drug delivery vehicles to ensure these disadvantages are minimized and the therapeutic benefits from the drug are optimized. With exquisitely tunable physical properties that confer them great controlled drug release features and the merits they offer for labile drug protection from degradation, hydrogels emerge as very efficient drug delivery systems. The versatility and diversity of the hydrogels extend their applications beyond targeted drug delivery also to wound dressings, contact lenses and tissue engineering to name but a few. They are 90% water, and highly porous to accommodate drugs for delivery and facilitate controlled release. Herein we discuss hydrogels and how they could be manipulated for targeted drug delivery applications. Suitable examples from the literature are provided that support the recent advancements of hydrogels in targeted drug delivery in diverse disease areas and how they could be suitably modified in very different ways for achieving significant impact in targeted drug delivery. With their enormous amenability to modification, hydrogels serve as promising delivery vehicles of therapeutic molecules in several disease conditions, including cancer and diabetes.
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31

Ma, Zhiyuan, Baicheng Li, Jie Peng, and Dan Gao. "Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation." Pharmaceutics 14, no. 2 (February 17, 2022): 434. http://dx.doi.org/10.3390/pharmaceutics14020434.

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Conventional drug administration usually faces the problems of degradation and rapid excretion when crossing many biological barriers, leading to only a small amount of drugs arriving at pathological sites. Therapeutic drugs delivered by drug delivery systems to the target sites in a controlled manner greatly enhance drug efficacy, bioavailability, and pharmacokinetics with minimal side effects. Due to the distinct advantages of microfluidic techniques, microfluidic setups provide a powerful tool for controlled synthesis of drug delivery systems, precisely controlled drug release, and real-time observation of drug delivery to the desired location at the desired rate. In this review, we present an overview of recent advances in the preparation of nano drug delivery systems and carrier-free drug delivery microfluidic systems, as well as the construction of in vitro models on-a-chip for drug efficiency evaluation of drug delivery systems. We firstly introduce the synthesis of nano drug delivery systems, including liposomes, polymers, and inorganic compounds, followed by detailed descriptions of the carrier-free drug delivery system, including micro-reservoir and microneedle drug delivery systems. Finally, we discuss in vitro models developed on microfluidic devices for the evaluation of drug delivery systems, such as the blood–brain barrier model, vascular model, small intestine model, and so on. The opportunities and challenges of the applications of microfluidic platforms in drug delivery systems, as well as their clinical applications, are also discussed.
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32

Dunuweera, Shashiprabha Punyakantha, Rajapakse Mudiyanselage Shashanka Indeevara Rajapakse, Rajapakshe Babilage Sanjitha Dilan Rajapakshe, Sudu Hakuruge Dilan Priyankara Wijekoon, Mallika Gedara Gayan Sasanka Nirodha Thilakarathna, and Rajapakse Mudiyanselage Gamini Rajapakse. "Review on Targeted Drug Delivery Carriers Used in Nanobiomedical Applications." Current Nanoscience 15, no. 4 (March 20, 2019): 382–97. http://dx.doi.org/10.2174/1573413714666181106114247.

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Targeted drug delivery (TDD) is an advanced and smart method of delivering drugs to the patients in a targeted sequence that increases the concentration of delivered drug only at the targeted body part of interest (organs/tissues/cells). This will in turn enhance efficacy of treatment by reducing side effects and the required dose of the drug. TDD ensures a certain defined minimally required constant amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body thereby avoiding any damage to the healthy tissue via the drug. Various drug carriers that are envisaged in advanced delivery systems are soluble polymers, inorganic nanoparticles, magnetic nanoparticles, biodegradable microsphere polymers (synthetic and natural), neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles and immune micelle. In selecting such a vehicle, important factors to consider are chemical and physical properties drugs, side effects or cytotoxicity to healthy cells, route to be taken for the delivery of the drug, the targeted site, and the disease. As such, TDD formulations are prepared by considering the specific properties of target cells, nature of markers or transport carriers or vehicles, which convey drug to specific receptors, and ligands and physically modulated components.
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33

Ali, Fayaz, Imran Khan, Jianmin Chen, Kalsoom Akhtar, Esraa M. Bakhsh, and Sher Bahadar Khan. "Emerging Fabrication Strategies of Hydrogels and Its Applications." Gels 8, no. 4 (March 24, 2022): 205. http://dx.doi.org/10.3390/gels8040205.

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Recently, hydrogels have been investigated for the controlled release of bioactive molecules, such as for living cell encapsulation and matrices. Due to their remote controllability and quick response, hydrogels are widely used for various applications, including drug delivery. The rate and extent to which the drugs reach their targets are highly dependent on the carriers used in drug delivery systems; therefore the demand for biodegradable and intelligent carriers is progressively increasing. The biodegradable nature of hydrogel has created much interest for its use in drug delivery systems. The first part of this review focuses on emerging fabrication strategies of hydrogel, including physical and chemical cross-linking, as well as radiation cross-linking. The second part describes the applications of hydrogels in various fields, including drug delivery systems. In the end, an overview of the application of hydrogels prepared from several natural polymers in drug delivery is presented.
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34

N’Diaye, Elisa-Racky, Nicola Salvatore Orefice, Catherine Ghezzi, and Ahcène Boumendjel. "Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery." Pharmaceutics 14, no. 3 (March 16, 2022): 653. http://dx.doi.org/10.3390/pharmaceutics14030653.

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Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs’ rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs’ use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers.
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Ramanjooloo, Avin, Raymond J. Andersen, and Archana Bhaw-Luximon. "Marine sponge-derived/inspired drugs and their applications in drug delivery systems." Future Medicinal Chemistry 13, no. 5 (March 2021): 487–504. http://dx.doi.org/10.4155/fmc-2020-0123.

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Oceans harbor a vast biodiversity that is not represented in terrestrial habitats. Marine sponges have been the richest source of marine natural products reported to date, and sponge-derived natural products have served as inspiration for the development of several drugs in clinical use. However, many promising sponge-derived drug candidates have been stalled in clinical trials due to lack of efficacy, off-target toxicity, metabolic instability or poor pharmacokinetics. One possible solution to this high clinical failure rate is to design drug delivery systems that deliver drugs in a controlled and specific manner. This review critically analyzes drugs/drug candidates inspired by sponge natural products and the potential use of drug delivery systems as a new strategy to enhance the success rate for translation into clinical use.
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Gadad, A. P., Vijay Kumar S M, P. M. Dandagi, U. B. Bolmol, and N. Pavani Pallavi. "Nanoparticles and their Therapeutic Applications in Pharmacy." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 3 (August 31, 2014): 2509–19. http://dx.doi.org/10.37285/ijpsn.2014.7.3.2.

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Nanotechnology is providing solutions several pharma-ceutical drug delivery issues. With the emergence of nanotechnology, researchers become more interested in studying the unique properties of nanoscale materials. Nanoparticles are attractive tool in pharmaceutical and biomedical fields. These particulate systems have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug/proteins. Nanoparticles have been used in-vivo to protect the drug/proteins molecules in the systemic circulation, targeting of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various types polymers have been used in the formulation of nanoparticles for drugs, proteins, and hormone delivery are discussed in this article. It also describes various methods of preparation, advantages, disadvantages and their applications in biomedical fields. It provides an overview of characterization of nanoparticles, storage, and commercially available nanoformulations.
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Kotta, Sabna, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, and Kamal YT. "Progress in Polymeric Micelles for Drug Delivery Applications." Pharmaceutics 14, no. 8 (August 5, 2022): 1636. http://dx.doi.org/10.3390/pharmaceutics14081636.

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Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core–shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent advances and understandings of PMs with a focus on the latest drug delivery applications. The types, methods of preparation and characterization of PMs are described along with their applications in oral, parenteral, transdermal, intranasal and other drug delivery systems. The applications of PMs for tumor-targeted delivery have been provided special attention. The safety, quality and stability of PMs in relation to drug delivery are also provided. In addition, advanced polymeric systems and special PMs are also reviewed. The in vitro and in vivo stability assessment of PMs and recent understandings in this area are provided. The patented PMs and clinical trials on PMs for drug delivery applications are considered indicators of their tremendous future applications. Overall, PMs can help overcome many unresolved issues in drug delivery.
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Langer, Robert. "Biomaterials: New Polymers and Novel Applications." MRS Bulletin 20, no. 8 (August 1995): 18–22. http://dx.doi.org/10.1557/s0883769400045061.

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The following is an edited transcript of the plenary lecture presented by Robert Langer at the 1995 MRS Spring Meeting on April 17, 1995 in San Francisco.Over the last 21 years I have been involved in examining and studying, and in some cases synthesizing new polymers and biomaterials, looking at how they might be able to solve two problems. One set of problems involves drug delivery; a second involves creating new tissues.Controlled drug release is a relatively young field that has involved a fundamental change in the way drugs are delivered. Transdermal drug delivery, for example, uses five layers of polymers, yet the whole system is 0.2 mm thick. One such polymer contains nitroglycerine, which is slowly released for one day from a patch through the skin into the blood circulation. This process provided a novel way to treat angina for patients with chest pains. First introduced in 1982, such drug-delivery systems saw a usage rate of over 500 million last year.Norplant systems, which are silicone capsules placed under the forearm, slowly release a birth-control drug for over 2,000 days, or five years, from what are actually six small implants about the size of match sticks. These two examples illustrate that drugs can be made to slowly diffuse through polymers over a long period of time.
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Kaur, Mandeep, Aditya Wadhwa, and Vineet Kumar. "Pectin-Based Nanomaterials: Synthesis, Toxicity and Applications." Asian Journal of Chemistry 33, no. 11 (2021): 2579–88. http://dx.doi.org/10.14233/ajchem.2021.23382.

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Nanomaterials of biological origin are very useful for drug delivery applications. The stability, biodegradability and biocompatibility of pectin nanomaterials in the human body make them an effective drug carrier. This review focus on different aspect of synthesis, drug encapsulation, drug release and safety of pectin-based nanomaterials. The nanomaterials can be used for the delivery of different hydrophilic and hydrophobic drugs to various organs. The release kinetics of drug loaded pectin-based nanoparticles can be studied in vitro as well as in vivo. The pectin-based nanomaterials have good pharmaco-kinetics and can ensure controlled drug delivery. However, the toxicity of pectin-based nanomaterials to human body needs to be evaluated carefully before industrial scale application.
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Pontes, Jorge F., and Ana Grenha. "Multifunctional Nanocarriers for Lung Drug Delivery." Nanomaterials 10, no. 2 (January 21, 2020): 183. http://dx.doi.org/10.3390/nano10020183.

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Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.
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Topuz, Fuat, and Tamer Uyar. "Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications." Pharmaceutics 11, no. 1 (December 24, 2018): 6. http://dx.doi.org/10.3390/pharmaceutics11010006.

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Electrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. In this regard, cyclodextrins (CyD) are considered as ideal drug carrier molecules as they are natural, edible, and biocompatible compounds with a truncated cone-shape with a relatively hydrophobic cavity interior for complexation with hydrophobic drugs and a hydrophilic exterior to increase the water-solubility of drugs. Further, the formation of CyD-drug inclusion complexes can protect drug molecules from physiological degradation, or elimination and thus increases the stability and bioavailability of drugs, of which the release takes place with time, accompanied by fiber degradation. In this review, we summarize studies related to CyD-functional electrospun nanofibers for drug delivery applications. The review begins with an introductory description of electrospinning; the structure, properties, and toxicology of CyD; and CyD-drug complexation. Thereafter, the release of various drug molecules from CyD-functional electrospun nanofibers is provided in subsequent sections. The review concludes with a summary and outlook on material strategies.
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Singh, Ruchita, Charles Brumlik, Mandar Vaidya, and Abhishek Choudhury. "A Patent Review on Nanotechnology-Based Nose-to-Brain Drug Delivery." Recent Patents on Nanotechnology 14, no. 3 (October 26, 2020): 174–92. http://dx.doi.org/10.2174/1872210514666200508121050.

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Background: Current cerebral drug delivery to the brain and Cerebrospinal Fluid (CSF) is limited by the Blood-Brain Barrier (BBB) or the blood-blood Cerebrospinal Fluid (CSF) barrier. The popular, non-invasive, intranasal delivery provides an exciting route for topical and systemic applications. For example, intranasal drug delivery of Central Nervous System (CNS) drugs can be designed to pass the BBB barrier via the nose-to-brain pathways. Recent nanotechnology research and patenting focus mainly on overcoming typical limitations including bioavailability, transport, BBB penetration, targeted delivery, controlled release rate and controlled degradation. Objective: The aim of the present study was to assess the state-of-the-art of nose-to-brain drug delivery systems and the role of nanotechnology in targeted delivery for the treatment of CNS and related therapeutic conditions. Methods: Patent and related searches were made with analytics to explore and organize nanotech work in intranasal drug delivery to the brain. Technical advancements were mapped by API, formulation and performance criteria. Patents and published patent applications were searched with concept tables of keywords, metadata (e.g., assignee) and patent classes (e.g., International Patent Classes and Cooperative Patent Classes). Results: The reviewed patents and published applications show a focus on formulations and therapeutic indications related to the nano-based nose-to-brain drug delivery. The main patented materials were surface modifiers, delivery systems and excipients. Conclusion: Surface modified nanoparticles can greatly improve drug transport and bioavailability of drugs, particularly higher molecular weight drugs. The most commonly used surface modifiers were chitosan, lectin and cyclodextrin-cross-linker complex. Nanoformulations of herbal drugs could increase drug bioavailability and reduce toxicity. Biotechnology-related drug delivery approaches such as monoclonal antibodies and genetically engineered proteins (molecular Trojan horses) deliver large molecule therapeutics.
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Chenglin, Zhang, Su Jihao, and Zhao Hongxia. "Suger-coated pillararenes for drug delivery applications." E3S Web of Conferences 185 (2020): 03048. http://dx.doi.org/10.1051/e3sconf/202018503048.

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Supramolecular drug delivery systems (SDDSs) provide a useful platform for smart and functional drug carriers owing to their high selectivity towards various guest molecules and stimulus-responsive properties. Pillar[n]arenes represent a new generation of macrocyclic hosts with unique structures and chemical properties. In recent times pillar[n]arenes have attracted considerable attention as ideal scaffolds for the construction of SDDSs. Since sugar functionalized pillar[n]arenes have good water solubility and excellent biocompatibility, they have been widely applied in supramolecular systems construction, such as nanoparticles, vesicles, and gels by non-covalent interactions, so as to meet the requirements of their applications in biomedicine. These SDDSs present good responsiveness, not only realizing targeted delivery and controllable release of drugs, but also improving drug solubility and reducing its toxic and side effects. Here, according to the different structure of the assembly, the SDDSs constructed by the sugar functionalized pillar[n]arenes are summarized, and the development prospect of the system is prospected.
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Lu, Haijiao, Jingkang Wang, Ting Wang, Jian Zhong, Ying Bao, and Hongxun Hao. "Recent Progress on Nanostructures for Drug Delivery Applications." Journal of Nanomaterials 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/5762431.

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With the rapid development of nanotechnology, the convergence of nanostructures and drug delivery has become a research hotspot in recent years. Due to their unique and superior properties, various nanostructures, especially those fabricated from self-assembly, are able to significantly increase the solubility of poorly soluble drugs, reduce cytotoxicity toward normal tissues, and improve therapeutic efficacy. Nanostructures have been successfully applied in the delivery of diverse drugs, such as small molecules, peptides, proteins, and nucleic acids. In this paper, the driving forces for the self-assembly of nanostructures are introduced. The strategies of drug delivery by nanostructures are briefly discussed. Furthermore, the emphasis is put on a variety of nanostructures fabricated from various building materials, mainly liposomes, polymers, ceramics, metal, peptides, nucleic acids, and even drugs themselves.
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Sarwar, Hafiz Shoaib, Muhammad Hanif, Aamir Jalil, Malik Suleman Haider, Fahad Naeem, Ahmad Nawaz, and Vesh Chaurasiya. "Microspheres for the Drug Delivery Applications." Pakistan Journal of Pharmaceutical Research 1, no. 1 (December 29, 2014): 9. http://dx.doi.org/10.22200/pjpr.201519-18.

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Conventional dosage forms provide a sharp increase in plasma drug levels that falls below the therapeutic range after short interval of time until the re-administration of drug. There is a need of such dosage forms which provide not only sustained drug delivery but also reduce the plasma drug levels fluctuations. Microspheres used in drug delivery systems due to their ability to sustain the drug release, their biodegradability and compatibility and targeted drug delivery. In this review different types of microspheres their methods for the preparation with different hydrophilic and hydrophobic polymers, drug loading capacities will be discussed. Different characterizations like SEM, FTIR, XRD, DSC, rheological properties and invitro drug release are successfully described.
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Ficai, Denisa, Mihai Sandulescu, Anton Ficai, Ecaterina Andronescu, Mehmet Yetmez, Omer Agrali, Eser Elemek, Oguzhan Gunduz, Yesim Sahin, and Faik Oktar. "Drug Delivery Systems for Dental Applications." Current Organic Chemistry 21, no. 1 (December 1, 2016): 64–73. http://dx.doi.org/10.2174/1385272820666160511104145.

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47

Simovic, Spomenka, Nasrin Ghouchi-Eskandar, Aw Moom Sinn, Dusan Losic, and Clive A. Prestidge. "Silica Materials in Drug Delivery Applications." Current Drug Discovery Technologies 8, no. 3 (September 1, 2011): 250–68. http://dx.doi.org/10.2174/157016311796799026.

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48

Khan, Zaheeda, Viness Pillay, Yahya E. Choonara, and Lisa C. du Toit. "Drug delivery technologies for chronotherapeutic applications." Pharmaceutical Development and Technology 14, no. 6 (November 3, 2009): 602–12. http://dx.doi.org/10.3109/10837450902922736.

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Khan, Zaheeda, Viness Pillay, Yahya E. Choonara, and Lisa C. du Toit. "Drug delivery technologies for chronotherapeutic applications." Pharmaceutical Development and Technology 00, no. 00 (May 5, 2009): 090505061814070–12. http://dx.doi.org/10.1080/10837450902922736.

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50

Namdeo, Mini, Sutanjay Saxena, Rasika Tankhiwale, M. Bajpai, Y. M. Mohan, and S. K. Bajpai. "Magnetic Nanoparticles for Drug Delivery Applications." Journal of Nanoscience and Nanotechnology 8, no. 7 (July 1, 2008): 3247–71. http://dx.doi.org/10.1166/jnn.2008.399.

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In recent past magnetic nanoparticles have been explored for a number of biomedical applications due to their superparamagnetic moment with high magnetic saturation value. For these biomedical applications, magnetic nanoparticles require being monodispersed so that the individual nanoparticle has almost identical physico-chemical properties for biodistribution, bioelimination and contrast imaging potential. Further, the surface functionalization/modification of magnetic nanoparticles ultimately facilitate the protein or DNA separation, detection and magnetic resonance imaging contrast, drug delivery and hyperthermia applications. The essential goal of this review is to evaluate the recent advances of magnetic nanoparticles for tumor, brain targeting and hyperthermia applications.
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