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Dissertations / Theses on the topic 'Drosophila muscles'

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Published: 6 September 2023

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1

Laddada, Lilia. "Etude du développement des tendons et de leur interaction avec les précurseurs de muscles lors de la myogenèse appendiculaire chez la Drosophile." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC011/document.

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La mise en place du système musculo-(exo)squelettique de la drosophile est un modèle d’organisation particulièrement propice à l’étude des interactions tissulaires au cours du développement.Notre étude vise à, d’une part, comprendre la myogenèse appendiculaire à travers l’étude des interactions précoces entre les précurseurs de tendon et les myoblastes, et d’autre part, étudier les mécanismes de différenciation des précurseurs de tendons associés au disque de patte. Dans ce contexte nous avons adapté la méthode GRASP (GFP Reconstitution Across Synaptic Partners) ainsi que l’imagerie en temps r
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2

Orfanos, Zacharias. "Dynamics of sarcomere assembly in drosophila indirect flight muscles." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533510.

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3

Cripps, Richard Matthew. "Genetical and biochemical studies of Drosophila indirect flight muscles." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276490.

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4

Varshney, Gaurav. "Identification of downstream targets of ALK signaling in Drosophila melanogaster /." Doctoral thesis, Umeå : Umeå universitet, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1894.

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5

Yang, Hairu. "Drosophila skeletal muscles regulate the cellular immune response against wasp infection." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125842.

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Drosophila melanogaster is widely used as a model organism to study the innate immune system because it lacks an adaptive immune response that could mask its innate immune response. The innate immune response of Drosophila primarily consists of humoral and cellular immune responses. The humoral immune response ismediated by antimicrobial peptides, and is induced by bacterial and fungal infections. The cellular immune response is mediated by blood cells (hemocytes), and is induced by bacterial and wasp infection. While the humoral immune response of Drosophila has been studied extensively, the
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6

Shirinian, Margret. "Midgut and muscle development in Drosophila melanogaster." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22137.

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The fully developed and functional Drosophila midgut comprises two layers, the visceral mesoderm and the endoderm. The visceral muscle of the midgut is formed by the fusion of founder cells with fusion competent cells to form the muscle syncytia. The specification of these cells and thus the fusion and the formation of the midgut muscle is dependent on the  Receptor tyrosine kinase (RTK) Alk (Loren et al., 2003). The endoderm underlies the visceral muscle and is formed from cells that originate from the anterior and the posterior parts of the embryo. These cells use the visceral mesoderm as a
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7

Islam, Riswana. "The role of [beta]FTZ-F1 in the innervation of the abdominal and pharyngeal muscles in Drosophila /." Connect to online version, 2005. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2005/92.pdf.

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8

Soler, Cédric. "La formation des muscles de la patte chez Drosophila melanogaster : un nouveau modèle d'étude de la myogenèse appendiculaire." Clermont-Ferrand 1, 2005. http://www.theses.fr/2005CLF1MM20.

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9

Bernard, Frédéric. "Etude du rôle du gène vestigial au cours de la myogenèse adulte chez Drosophila Melanogaster." Paris 7, 2006. http://www.theses.fr/2006PA077073.

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Drosophila melanogaster est un système modèle particulièrement adapté à la génétique du développement. La facilité d'entretien et de stockage des différentes lignées, une large collection de lignées mutantes à disposition et de nombreux outils génétiques sont les plus gros avantages de ce système d'étude. Chez la drosophile, le thorax contient l'ensemble des muscles nécessaires au vol de la mouche. Parmi ceux-ci on distingue de petits muscles tubulaires qui sont directement attachés à l'aile : les muscles directs du vol (DFM : Direct Flight Muscles) et de plus grands muscles attachés à l'exosq
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10

Caine, Charlotte. "Etude des interactions entre MEF2 et la voie de signalisation Notch au cours de la myogenèse adulte chez Drosophila melanogaster." Paris 7, 2012. http://www.theses.fr/2012PA077248.

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La myogenèse des muscles indirects du vol (IFM) chez Drosophila melanogaster suit un schéma développemental précis. Au cours de l'embryogenèse, un groupe de cellules, les Précurseurs adultes Musculaires (AMP) se spécifient. Ces cellules deviennent des myoblastes qui prolifèrent au cours des stades larvaires et donneront par la suite les IFM adultes. Nos travaux se sont concentrés sur les interactions requises lors de la transition de myoblastes qui prolifèrent au statut de myoblaste différencié prêt à fusionner à la fibre musculaire. Il a été montré que les myoblastes qui prolifèrent ont une v
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11

Lavergne, Guillaume. "Caractérisation des précurseurs de muscles adultes et de leurs interactions au cours de l'embryogenèse chez Drosophila melanogaster." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC105.

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Les précurseurs de muscles adultes (ou AMPs) représentent une population transitoire de cellules souches musculaires chez la Drosophile. Ces cellules dérivent du mésoderme embryonnaire et sont caractérisées par l’activation de la voie Notch ainsi que par le maintien d’une forte expression du facteur de transcription Twist (de type basic helix loop helix). La répartition des AMPs chez la larve est établie au cours de l’embryogénèse de manière stéréotypée : on distingue 6 AMPs par hémisegment abdominal en position ventrale, latérale, dorso-latérale et dorsale. Après spécification et jusqu’au déb
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12

Sevdali, Maria. "Drosophila indirect flight muscles as a model system for the study of human thin filament myopathies." Thesis, University of York, 2009. http://etheses.whiterose.ac.uk/21058/.

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Human thin filament myopathies are a group of skeletal muscle diseases caused by mutations in thin filament protein genes. Over 170 mutations within the human skeletal Cl-actin gene, ACTA1, cause congenital actin myopathies (CAM). These are dominant, often lethal mutations resulting in death at birth or shortly after. Several mutations have been identified in the genes encoding for Troponin I and Troponin T proteins, which cause arthrogryposis. The aim of this work was to see if the Drosophila Indirect Flight Muscles can be used as a genetic model system, with which to study the ACTA1 and arth
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13

Franco-Cea, Omar Ari. "The role of microtubular motors and other cytoskeletal proteins in the development of Drosophila melanogaster indirect flight muscles." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444303.

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14

Wester, Jorge Victor Wilfredo Cachay. "Caracterização molecular do módulo regulador TT (Traqueia-Tórax) de >Drosophila melanogaster." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06062017-163006/.

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Estudos funcionais anteriores identificaram um módulo cis-regulador (MCR) de 67 pb (-253/- 187) na região promotora do gene de pufe de DNA BhC4-1 que dirige a expressão do gene repórter na glândula anelar de Drosophila melanogaster. Uma análise bioinformática identificou 67 sequências de D. melanogaster que são similares a sequências contidas no MCR de glândula anelar. Uma das sequências identificadas reside em um fragmento genômico de 657 pb localizado aproximadamente 2500 pb à montante do CG13711, 400 pb à montante do CG12493, em uma região genômica que constitui um dos íntrons do CG32239 (G
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15

Chakravorty, Samya. "Role of the Drosophila Melanogaster Indirect Flight Muscles in Flight and Male Courtship Song: Studies on Flightin and Mydson Light Chain - 2." ScholarWorks @ UVM, 2013. http://scholarworks.uvm.edu/graddis/1.

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Complex behaviors using wings have facilitated the insect evolutionary success and diversification. The Drosophila indirect flight muscles (IFM) have evolved a highly ordered myofilament lattice structure and uses oscillatory contractions by pronounced stretch activation mechanism to drive the wings for high powered flight subject to natural selection. Moreover, the IFM is also utilized during small amplitude wing vibrations for species-specific male courtship song (sine and pulse), an important Drosophila mating behavior subject to sexual selection. Unlike flight, the contractile mechanism an
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16

Kasherov, Petar. "Etude de la régulation du gène vestigial au cours de la myogenèse adulte chez Drosophila melanogaster." Paris 7, 2010. http://www.theses.fr/2010PA077112.

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Chez la drosophile deux vagues de myogenèse ont lieu - la myogenèse larvaire et la myogenèse adulte. La première permet la formation de la musculature larvaire alors que la deuxième aboutit à la formation de l'ensemble des muscles adultes y compris les muscles du vol. Les muscles du vol se subdivisent en muscles directs du vol (Direct Flight Muscles - DFM) et muscles indirects du vol (Indirect Flight Muscles - IFM). Au cours de ma thèse je me suis focalisé sur la régulation d'un des facteurs myogéniques clé pour la formation des IFM - le gène vestigial (vg). Nous avons montré que sa régulation
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17

Aradhya, Rajaguru. "Characterization of quiescent state and reactivation of adult muscle precursor cells in Drosophila melanogaster." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM16.

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Pas de résumé disponible<br>Use of stem cells in regenerative medicine has attracted great interest in the past decade. Muscle stem cells such as satellite cells were shown to regenerate skeletal muscle tissue after injury and to contribute to muscle growth. These properties have raised an enormous interest in using satellite cells for the therapy of skeletal muscle wasting disorders where the intrinsic stem cell population is unable to repair muscle tissue. However, better understanding of the mechanisms controlling satellite cell lineage progression and self-renewal is crucial to exploit the
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18

Maity, Chaitali. "Determining the role of a candidate gene in Drososphila muscle development." Oxford, Ohio : Miami University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1145459719.

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19

Hancock, Daniel H. "Role of Mef2 in Drosophila muscle development." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55033/.

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Muscle differentiation is a complex process involving the transition from undifferentiated mesoderm to a final functional musculature. Mef2 is an essential positive regulator central to the co-ordination of this process. It targets a plethora of key genes both early and late in the differentiation program and its activity must be tightly controlled (Pothoff and Olson, 2007). The aim of my research was to investigate the role of Mef2 in orchestrating Drosophila muscle differentiation. I did this by analysing the formation of the larval somatic musculature under conditions that either increased
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20

Liotta, David. "Dmeso17A : a novel inhibitor of Drosophila muscle differentiation." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/56020/.

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Muscle differentiation is a complex process finely tuned by the interplay of positive and negative factors. Although key positive regulators have been identified, there is rather little evidence of restraining molecules that can control the time and place of muscle differentiation. Identification of such molecules and analysis of their function during muscle differentiation is therefore necessary to gain new insight into the molecular events that regulate this process. My work centred on a gene, Dmeso17A that was identified in the Taylor laboratory in a screen to isolate novel genes specifical
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21

Schönbauer, Cornelia. "Genetic analysis of Drosophila adult muscle type specification." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-170130.

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Muscles of all higher animals comprise different muscle types adapted to perform distinct functions in the body. These express different sets of genes controlled by distinct combinations of transcriptional programs and extracellular signals, and thus differ in their myofibrillar organization and contractile properties. Despite major progress in our understanding of myogenesis, the genetic pathways controlling the formation and function of different muscle types are still largely uncharacterized. Flying insects possess specialized flight muscles enabling wing oscillations with frequencies of
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22

Weitkunat, Manuela. "Mechanistic dissection of adult muscle formation in Drosophila." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-178864.

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23

Vishal, Kumar. "EGF signaling regulates adult muscle patterning in Drosophila." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1416505009.

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24

Frei, Ryan. "Regulatory Elements of Drosophila Non-Muscle Myosin II." Thesis, University of Oregon, 2013. http://hdl.handle.net/1794/12954.

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Non-muscle myosin II (NM-II) is present in every cell type and moves actin filaments to provide contraction within the cell. NM-II has a motor domain, a neck domain that binds two light chains, a long coiled-coil tail domain, and a carboxyl-terminal tailpiece. NM-II forms bipolar filaments by associating near the carboxyl-terminus of the tail. It has long been known that both the formation of bipolar filaments and enzymatic activity of the motor domain are regulated by phosphorylation of one of the neck-binding light chains, known as the regulatory light chain (RLC). This phosphorylation cause
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25

Sudarsan, Vikram. "Coordinating cell fate signalling during Drosophila development." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247190.

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26

Boukhatmi, Hadi. "Mise en place de l'identité des muscles au cours de la spécification des myoblastes chez la drosophile." Toulouse 3, 2012. http://thesesups.ups-tlse.fr/1777/.

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La formation des muscles squelettiques au cours de l'embryogenèse de la drosophile est un modèle d'étude du contrôle génétique de la différentiation cellulaire. La formation de chaque muscle comprend quatre étapes successives: spécification d'un groupe promusculaire, sélection d'un progéniteur (PC) à partir de ce groupe, division asymétrique de ce progéniteur pour donner des cellules fondatrices de muscles (FC) ; fusion de chaque FC avec des myoblastes compétents (FCM), suivie de la différenciation musculaire. Chaque muscle squelettique est composé d'une fibre. Chaque muscle présente des propr
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27

Taffin, de Tilques Mathilde de. "Contrôle transcriptionnel de l'identité musculaire chez la drosophile : modules cis-régulateurs et gènes cibles directs de Collier." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2232/.

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Les facteurs de transcription (FT) COE (Col-EBF) sont conservés chez les métazoaires et participent au contrôle de divers processus biologiques : hématopoïèse, neurogenèse, myogenèse. Leur dérégulation entraîne de graves dysfonctionnements chez les mammifères (défauts de spécification des lymphocytes B, de sous-types neuronaux. . . ). Cependant les gènes cibles régulés par les FT COE restent majoritairement inconnus. Notre équipe utilise la drosophile comme système modèle pour étudier la spécificité d'action des FT COE selon le contexte cellulaire. Mon travail de thèse est centré sur l'identif
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Render, Timothy John. "A study of muscle pattern formation in Drosophila melanogaster." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240123.

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Harrison, Andrew. "Suppression of indirect flight muscle mutants in Drosophila melanogaster." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297111.

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30

Collins, Mary Ann. "Mechanisms of nuclear movement during muscle development in Drosophila:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108690.

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Thesis advisor: Eric S. Folker<br>Skeletal muscle is a syncytial cell type in which the multiple nuclei are evenly spaced along the cell periphery. During muscle development, the myonuclei undergo an elaborate set of movements to achieve this precise positioning throughout the muscle. The importance of proper nuclear positioning is highlighted by the correlation between mispositioned nuclei and muscle disease. However, the mechanisms that govern this energetically expensive process as well as the influence nuclear positioning has on muscle cell function remains to be elucidated. The goal of th
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31

Picchio, Lucie. "Mise en place, caractérisation phénotypique et transcriptomique d'un modèle de Drosophilie de la Dystrophie Myotonique de type 1." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM15/document.

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La dystrophie myotonique de type 1 (DM1) ou maladie de Steinert est la maladie génétique neuromusculaire la plus commune avec une incidence de 1/8000 à travers le monde. Cette maladie multisystémique touche particulièrement les muscles squelettiques (myotonie, faiblesse et perte musculaires) et le coeur qui présente des symptômes variés comme des troubles de la conduction et des arythmies. La DM1 est causée par une expansion instable de répétitions CTG dans la région 3’ non traduite du gène DMPK. Les individus sains possèdent entre 5 et 37 répétitions CTG tandis que les patients DM1 portent en
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Clayton, Jonathan David. "Suppression of a mutation in the Act88F gene of Drosophila melanogaster." Thesis, University of York, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387180.

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33

Green, Hannah Jane. "Diverse functions for intern associated proteins in Drosophila adult muscle." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/264024.

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The ability to adhere to the extracellular matrix (ECM) is critical for numerous cell types and tissues including epithelia and muscle. Cell-ECM adhesion is primarily mediated by integrins which provide a direct link between the ECM and the actin cytoskeleton. Integrin adhesions are frequently associated with a core of 60 different proteins (integrin-associated proteins, IAPs). Integrins are required for muscle attachment and in Drosophila, loss of integrins and several IAPs results in embryonic lethality and muscle detachment. However, the IAPs FAK, RSU1, tensin, vinculin and zyxin are not re
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34

Belu, Mirela. "Comparative Analysis of Muscle and Locomotion Patterns in Drosophila Species." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301331017.

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35

Miller, Becky M. "Functional analysis of Drosophila melanogaster muscle myosin heavy chain alternative domains /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3138951.

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36

Chang, Whei-meih. "Identification of transcriptional regulatory elements in muscle promoter of Ca⁺⁺-activated potassium channel, slowpoke, in Drosophila /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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37

Ricketson, Derek Lee. "Drosophila non-muscle myosin II bipolar filament formation : importance of charged residues and specific domains for self-assembly /." Connect to title online (Scholars' Bank) Connect to title online (ProQuest), 2009. http://hdl.handle.net/1794/10285.

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38

Gunthorpe, D. "Muscle differentiation in Drosophila : analysis of the roles of DMEF2 and Dmeso47C." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599783.

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In this dissertation, two approaches are taken to gain a greater understanding of muscle differentiation in <I>Drosophila.</I> The first is to analyse the role of a gene, <I>Dmef2</I>, which is already known, from work in both vertebrates and <I>Drosophila,</I> to be essential for this process. Two specific aspects of the role of <I>Dmef2</I> in muscle differentiation are analysed: the function of different levels of the protein and the role of the different isoforms. It is shown that different properties within a cell require distinct threshold levels of DMEF2, as do different cells within a
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Wong, Ming-Ching. "Regulation of twist activity during mesoderm and somatic muscle development in drosophila /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1642921011&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Laurichesse, Quentin. "Caractérisation génétique des précurseurs de tendons appendiculaires au cours des étapes précoces de la métamorphose chez Drosophila melanogaster : rôle du Krüppel-like factor Dar1 dans le développement des précurseurs de tendons appendiculaires." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAC072.

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La mise en place de l’architecture musculo-squelettique émerge d’un développement coordonné inter-tissulaire entre muscles et tissus conjonctifs, dont l’agencement requiert une communication permanente lors des stades embryonnaires. En dépit de l’absence de squelette interne, la patte de la drosophile possède à l’instar des vertébrés des longs tendons internes, auxquels sont rattachés les muscles. Ces sites d’attachements partagent avec mammifères, à la fois l’aspect fonctionnel des tendons à savoir rattacher les muscles et permettre la locomotion, mais également des aspects moléculaires, avec
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Schönbauer, Cornelia [Verfasser], and Matthias [Akademischer Betreuer] Mann. "Genetic analysis of Drosophila adult muscle type specification / Cornelia Schönbauer. Betreuer: Matthias Mann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1052778852/34.

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42

Katzemich, Anja R. "Expression and function of the large modular muscle protein Obscurin in Drosophila melanogaster." Thesis, University of York, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533525.

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43

Weitkunat, Manuela Verfasser], and Ulrike [Akademischer Betreuer] [Gaul. "Mechanistic dissection of adult muscle formation in Drosophila / Manuela Weitkunat. Betreuer: Ulrike Gaul." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1066206600/34.

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44

Jagla, Teresa. "Etude de la fonction des genes a homeoboite, ladybird, dans la myogenese chez drosophila melanogaster (doctorat)." Clermont-Ferrand 1, 2000. http://www.theses.fr/2000CLF1MM09.

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45

Perkins, Alexander David. "A systematic analysis of the role of the cytoskeleton in Drosophila melanogaster muscle maintenance." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44235.

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Animal muscles must maintain their function while bearing substantial mechanical loads and undergoing numerous contraction/extension cycles. How muscles withstand persistent mechanical strain is presently not well understood. The basic unit of muscle is the sarcomere, which is primarily composed of cytoskeletal proteins. I hypothesized that cytoskeletal proteins undergo renewal via protein turnover and that this is required to maintain muscle function. Using the adult flight muscles of the fruit fly, Drosophila melanogaster, I confirmed that the sarcomeric cytoskeleton undergoes turnover throu
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Manieu, Seguel Catalina Paz. "The role of muscle-tendon cell interaction during epithelial notum morphogenesis of Drosophila melanogaster." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/168536.

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Grado de Doctora en Ciencias biomédicas<br>Tissue-tissue interaction is essential to drive morphogenesis and contributing to the final shape of tissues and organs. The interaction between muscles and tendons during the establishment of the muscle-skeletal system is a great model to study this problem. During Drosophila melanogaster metamorphosis a group of cells of the dorsal thorax (notum) epithelium, specialized as tendon cells, attach to the developing Indirect Flight Muscles (IFMs). Likewise, epithelial cells anchor to the cuticle exoskeleton through apical projections. Both interactions
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Jacques, Cécile. "Etude du rôle et du mécanisme d'action des facteurs de transcription glial cell deficient/glial cells missing au cours du développement." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/JACQUES_Cecile_2007.pdf.

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Les facteurs de transcription Gcm et Gcm2 sont connus pour leur rôle de déterminants gliaux et plasmatocytaires chez l’embryon de drosophile. Lors de ma thèse, j’ai mis en évidence que les gènes gcm-gcm2 sont requis pour la différenciation terminale d’une sous-population de cellules tendon. Par la suite, nous avons montré que l’orthologue c-GCM1 chez le poulet est requis lors de l’embryogenèse pour la différenciation des précurseurs neuraux de la moelle épinière en neurones. De façon surprenante, nous avons également mis en évidence que les gènes de type gcm sont exprimés et requis dans des li
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48

Rodriguez, Deyra Marie. "Isolation and characterization of stretchin-myosin light chain kinase mutants in drosophila melanogaster." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1079994503.

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49

Suslak, Thomas James. "There and back again : a stretch receptor's tale." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/10474.

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Abstract:
Mechanotransduction is fundamental to many sensory processes, including balance, hearing and motor co-ordination. However, for such an essential feature, the mechanism(s) that underlie it are poorly understood. The mechanotransducing stretch receptors that relay information on the tonicity and length of skeletal muscles have been well-defined, particularly at the gross anatomical level, in a wide variety of species, encompassing both vertebrates and invertebrates. To date, there exists a wealth of data describing them, anatomically, as well as good electrophysiological data from stretch recept
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50

Zhou, Lili. "The role of Lasp in the «Drosophila» male stem cell niche and in muscle development." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95064.

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Abstract:
Drosophila Lasp is the only member of the nebulin family in Drosophila. Lasp has an amino-terminal LIM domain, two actin-binding nebulin repeats and a carboxyl-terminal SH3 domain and exhibits very high homology to human Lasp. To assess Lasp function in vivo, we generated a null mutant in Drosophila Lasp, named Lasp1. Lasp1 mutants are homozygous viable, but male sterile. Lasp localizes to cyst cells, early germ cells, hub cells and actin cones. In Lasp1 mutants, the stem cell niche is no longer anchored to the apical tip of the testis, and actin cone migration is perturbed resulting in improp
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