Relevant bibliographies by topics / Drosophila muscles

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Drosophila muscles'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Drosophila muscles"

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Haines, Nicola, Sara Seabrooke, and Bryan A. Stewart. "Dystroglycan and Protein O-Mannosyltransferases 1 and 2 Are Required to Maintain Integrity of Drosophila Larval Muscles." Molecular Biology of the Cell 18, no. 12 (December 2007): 4721–30. http://dx.doi.org/10.1091/mbc.e07-01-0047.

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In vertebrates, mutations in Protein O-mannosyltransferase1 (POMT1) or POMT2 are associated with muscular dystrophy due to a requirement for O-linked mannose glycans on the Dystroglycan (Dg) protein. In this study we examine larval body wall muscles of Drosophila mutant for Dg, or RNA interference knockdown for Dg and find defects in muscle attachment, altered muscle contraction, and a change in muscle membrane resistance. To determine if POMTs are required for Dg function in Drosophila, we examine larvae mutant for genes encoding POMT1 or POMT2. Larvae mutant for either POMT, or doubly mutant for both, show muscle attachment and muscle contraction phenotypes identical to those associated with reduced Dg function, consistent with a requirement for O-linked mannose on Drosophila Dg. Together these data establish a central role for Dg in maintaining integrity in Drosophila larval muscles and demonstrate the importance of glycosylation to Dg function in Drosophila. This study opens the possibility of using Drosophila to investigate muscular dystrophy.
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Tracy, Claire B., Janet Nguyen, Rayna Abraham, and Troy R. Shirangi. "Evolution of sexual size dimorphism in the wing musculature of Drosophila." PeerJ 8 (January 17, 2020): e8360. http://dx.doi.org/10.7717/peerj.8360.

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Male courtship songs in Drosophila are exceedingly diverse across species. While much of this variation is understood to have evolved from changes in the central nervous system, evolutionary transitions in the wing muscles that control the song may have also contributed to song diversity. Here, focusing on a group of four wing muscles that are known to influence courtship song in Drosophila melanogaster, we investigate the evolutionary history of wing muscle anatomy of males and females from 19 Drosophila species. We find that three of the wing muscles have evolved sexual dimorphisms in size multiple independent times, whereas one has remained monomorphic in the phylogeny. These data suggest that evolutionary changes in wing muscle anatomy may have contributed to species variation in sexually dimorphic wing-based behaviors, such as courtship song. Moreover, wing muscles appear to differ in their propensity to evolve size dimorphisms, which may reflect variation in the functional constraints acting upon different wing muscles.
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Fernandes, J., and K. VijayRaghavan. "The development of indirect flight muscle innervation in Drosophila melanogaster." Development 118, no. 1 (May 1, 1993): 215–27. http://dx.doi.org/10.1242/dev.118.1.215.

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We have examined the development of innervation to the indirect flight muscles of Drosophila. During metamorphosis, the larval intersegmental nerve of the mesothorax is remodelled to innervate the dorsal longitudinal muscles and two of the dorsoventral muscles. Another modified larval nerve innervates the remaining dorsoventral muscle. The dorsal longitudinal muscles develop using modified larval muscles as templates while dorsoventral muscles develop without the use of such templates. The development of innervation to the two groups of indirect flight muscles differs in spatial and temporal patterns, which may reflect the different ways in which these muscles develop. The identification of myoblasts associated with thoracic nerves during larval life and the association of migrating myoblasts with nerves during metamorphosis indicate the existence of nerve-muscle interactions during indirect flight muscle development. In addition, the developing pattern of axonal branching suggests a role for the target muscles in respecifying neuromuscular junctions during metamorphosis.
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Gomez Ruiz, M., and M. Bate. "Segregation of myogenic lineages in Drosophila requires numb." Development 124, no. 23 (December 1, 1997): 4857–66. http://dx.doi.org/10.1242/dev.124.23.4857.

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Terminal divisions of myogenic lineages in the Drosophila embryo generate sibling myoblasts that found larval muscles or form precursors of adult muscles. Alternative fates adopted by sibling myoblasts are associated with distinct patterns of gene expression. Genes expressed in the progenitor cell are maintained in one sibling and repressed in the other. These differences depend on an asymmetric segregation of Numb between sibling cells. In numb mutants, muscle fates associated with repression are duplicated and alternative muscles are lost. If numb is overexpressed the reverse transformation occurs. Numb acts to block Notch-mediated repression of genes expressed in muscle progenitor cells. Thus asymmetric cell divisions are essential determinants of muscle fates during myogenesis in Drosophila
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Fernandes, J. J., and H. Keshishian. "Nerve-muscle interactions during flight muscle development in Drosophila." Development 125, no. 9 (May 1, 1998): 1769–79. http://dx.doi.org/10.1242/dev.125.9.1769.

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During Drosophila pupal metamorphosis, the motoneurons and muscles differentiate synchronously, providing an opportunity for extensive intercellular regulation during synapse formation. We examined the existence of such interactions by developmentally delaying or permanently eliminating synaptic partners during the formation of indirect flight muscles. When we experimentally delayed muscle development, we found that although adult-specific primary motoneuron branching still occurred, the higher order (synaptic) branching was suspended until the delayed muscle fibers reached a favourable developmental state. In reciprocal experiments we found that denervation caused a decrease in the myoblast pool. Furthermore, the formation of certain muscle fibers (dorsoventral muscles) was specifically blocked. Exceptions were the adult muscles that use larval muscle fibers as myoblast fusion targets (dorsal longitudinal muscles). However, when these muscles were experimentally compelled to develop without their larval precursors, they showed an absolute dependence on the motoneurons for their formation. These data show that the size of the myoblast pool and early events in fiber formation depend on the presence of the nerve, and that, conversely, peripheral arbor development and synaptogenesis is closely synchronized with the developmental state of the muscle.
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Poovathumkadavil, Preethi, and Krzysztof Jagla. "Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila." Cells 9, no. 6 (June 25, 2020): 1543. http://dx.doi.org/10.3390/cells9061543.

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In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as hatching in the embryo, crawling in the larva, and jumping and flying in adult flies all muscle components need to be maintained in a functionally stable or homeostatic state despite constant strain. This requires that the muscles develop in a coordinated manner with appropriate connections to other cell types they communicate with. Various signaling pathways as well as extrinsic and intrinsic factors are known to play a role during Drosophila muscle development, diversification, and homeostasis. In this review, we discuss genetic control mechanisms of muscle contraction, development, and homeostasis with particular emphasis on the contractile unit of the muscle, the sarcomere.
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Rout, Pratiti, Mathieu Preußner, and Susanne Filiz Önel. "Drosophila melanogaster: A Model System to Study Distinct Genetic Programs in Myoblast Fusion." Cells 11, no. 3 (January 19, 2022): 321. http://dx.doi.org/10.3390/cells11030321.

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Muscle fibers are multinucleated cells that arise during embryogenesis through the fusion of mononucleated myoblasts. Myoblast fusion is a lifelong process that is crucial for the growth and regeneration of muscles. Understanding the molecular mechanism of myoblast fusion may open the way for novel therapies in muscle wasting and weakness. Recent reports in Drosophila and mammals have provided new mechanistic insights into myoblast fusion. In Drosophila, muscle formation occurs twice: during embryogenesis and metamorphosis. A fundamental feature is the formation of a cell–cell communication structure that brings the apposing membranes into close proximity and recruits possible fusogenic proteins. However, genetic studies suggest that myoblast fusion in Drosophila is not a uniform process. The complexity of the players involved in myoblast fusion can be modulated depending on the type of muscle that is formed. In this review, we introduce the different types of multinucleated muscles that form during Drosophila development and provide an overview in advances that have been made to understand the mechanism of myoblast fusion. Finally, we will discuss conceptual frameworks in cell–cell fusion in Drosophila and mammals.
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Lin, S. C., M. H. Lin, P. Horvath, K. L. Reddy, and R. V. Storti. "PDP1, a novel Drosophila PAR domain bZIP transcription factor expressed in developing mesoderm, endoderm and ectoderm, is a transcriptional regulator of somatic muscle genes." Development 124, no. 22 (November 15, 1997): 4685–96. http://dx.doi.org/10.1242/dev.124.22.4685.

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In vertebrates, transcriptional control of skeletal muscle genes during differentiation is regulated by enhancers that direct the combinatorial binding and/or interaction of MEF2 and the bHLH MyoD family of myogenic factors. We have shown that Drosophila MEF2 plays a role similar to its vertebrate counterpart in the regulation of the Tropomyosin I gene in the development of Drosophila somatic muscles, however, unlike vertebrates, Drosophila MEF2 interacts with a muscle activator region that does not have binding sites for myogenic bHLH-like factors or any other known Drosophila transcription factors. We describe here the isolation and characterization of a component of the muscle activator region that we have named PDP1 (PAR domain protein 1). PDP1 is a novel transcription factor that is highly homologous to the PAR subfamily of mammalian bZIP transcription factors HLF, DBP and VBP/TEF. This is the first member of the PAR subfamily of bZIP transcription factors to be identified in Drosophila. We show that PDP1 is involved in regulating expression of the Tropomyosin I gene in somatic body-wall and pharyngeal muscles by binding to DNA sequences within the muscle activator that are required for activator function. Mutations that eliminate PDP1 binding eliminate muscle activator function and severely reduce expression of a muscle activator plus MEF2 mini-enhancer. These and previous results suggest that PDP1 may function as part of a larger protein/DNA complex that interacts with MEF2 to regulate transcription of Drosophila muscle genes. Furthermore, in addition to being expressed in the mesoderm that gives rise to the somatic muscles, PDP1 is also expressed in the mesodermal fat body, the developing midgut endoderm, the hindgut and Malpighian tubules, and the epidermis and central nervous system, suggesting that PDP1 is also involved in the terminal differentiation of these tissues.
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Callahan, C. A., J. L. Bonkovsky, A. L. Scully, and J. B. Thomas. "derailed is required for muscle attachment site selection in Drosophila." Development 122, no. 9 (September 1, 1996): 2761–67. http://dx.doi.org/10.1242/dev.122.9.2761.

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During development, muscles must form and attach at highly stereotyped positions to allow for coordinated movements. In Drosophila, muscles grow towards and attach to specifically positioned cells within the epidermis. At the molecular level, very little is known about how muscles recognize these attachment sites. The derailed gene encodes a receptor tyrosine kinase family member that is essential for the pathfinding ability of expressing neurons. Here we show that the Drl RTK is also expressed by a small subset of developing embryonic muscles and neighboring epidermal cells during muscle attachment site selection. In drl mutants, these muscles often fail to attach at appropriate locations although their epidermal attachment cells appear unaffected. These results show that, similar to its role in neuronal pathway recognition, the Drl RTK participates in a mechanism required for muscle attachment site selection. The data suggest that both neurons and muscles use common mechanisms to recognize their paths or targets, and that Drl plays an analogous role in both developing systems.
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Chaturvedi, Dhananjay, Sunil Prabhakar, Aman Aggarwal, Krishan B. Atreya, and K. VijayRaghavan. "Adult Drosophila muscle morphometry through microCT reveals dynamics during ageing." Open Biology 9, no. 6 (June 2019): 190087. http://dx.doi.org/10.1098/rsob.190087.

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Indirect flight muscles (IFMs) in adult Drosophila provide the key power stroke for wing beating. They also serve as a valuable model for studying muscle development. An age-dependent decline in Drosophila free flight has been documented, but its relation to gross muscle structure has not yet been explored satisfactorily. Such analyses are impeded by conventional histological preparations and imaging techniques that limit exact morphometry of flight muscles. In this study, we employ microCT scanning on a tissue preparation that retains muscle morphology under homeostatic conditions. Focusing on a subset of IFMs called the dorsal longitudinal muscles (DLMs), we find that DLM volumes increase with age, partially due to the increased separation between myofibrillar fascicles, in a sex-dependent manner. We have uncovered and quantified asymmetry in the size of these muscles on either side of the longitudinal midline. Measurements of this resolution and scale make substantive studies that test the connection between form and function possible. We also demonstrate the application of this method to other insect species making it a valuable tool for histological analysis of insect biodiversity.
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Dissertations / Theses on the topic "Drosophila muscles"

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Laddada, Lilia. "Etude du développement des tendons et de leur interaction avec les précurseurs de muscles lors de la myogenèse appendiculaire chez la Drosophile." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC011/document.

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La mise en place du système musculo-(exo)squelettique de la drosophile est un modèle d’organisation particulièrement propice à l’étude des interactions tissulaires au cours du développement.Notre étude vise à, d’une part, comprendre la myogenèse appendiculaire à travers l’étude des interactions précoces entre les précurseurs de tendon et les myoblastes, et d’autre part, étudier les mécanismes de différenciation des précurseurs de tendons associés au disque de patte. Dans ce contexte nous avons adapté la méthode GRASP (GFP Reconstitution Across Synaptic Partners) ainsi que l’imagerie en temps réel à notre modèle pour démontrer l’existence des interactions cellulaires entre les précurseurs de tendons et les myoblastes, nous avons aussi mis au point une approche cellule-spécifique afin de trier les précurseurs de tendons et les myoblastes associés au disque de patte, ce qui nous a permis d’obtenir dans un premier temps les données transcriptomiques des précurseurs de tendons. J’ai également étudié l’impact de l’altération des précurseurs de tendon sur le comportement des myoblastes associés et inversement. Nos résultats montrent que l’altération du développement des tendons entraîne une désorganisation spatiale des myoblastes environnants. Dans la seconde partie de mon projet, je me suis intéressée à l’implication de la voie Notch et des gènes de la famille odd-skipped dans la différenciation et la morphogenèse des précurseurs de tendon. J’ai ainsi démontré que Notch est nécessaire et localement suffisant pour induire l’expression de stripe et que les gènes odd-skipped et stripe coopèrent en aval cette voie pour permettre l’invagination et l’élongation sous forme de tube des longs tendons internes de la patte
The formation of the musculo-(exo)skeletal system in drosophila is a remarkable example of tissue patterning making it a suitable model for studying multiple tissue interactions during development.The aim of our study is to better understand appendicular myogenesis through the identification of early interactions between tendon and muscle precursors, and by investigating the mechanisms governing the specification of tendon cell precursors of the leg disc. In order to characterize the interaction between these two tissues, we adapted the GRASP method (GFP Reconstitution Across Synaptic Partners) and set up live imaging experiments to reveal cellular interactions between tendon precursors and myoblasts. We have also conducted a genome wide cell-specific analysis using Fluorescence-activated cell sorting (FACS) on imaginal discs which allowed us to perform a tendon cell specific transcriptional analysis.To test whether reciprocal muscle-tendon interactions are necessary for correct muscle-tendon development, I performed experiments to specifically interfere with the development of tendon or muscle precursors. By altering tendon precursors formation during the early steps of leg development, we affect the spatial localization of the associated myoblasts. These findings provide the first evidence of the developmental impact of early interactions between muscle and tendon precursors in the leg disc.In the second part of my project, I investigated the role of Notch pathway and odd-skipped genes in the differentiation and morphogenesis of tendon precursors. Thus, I have demonstrated that Notch signalling pathway is necessary and locally sufficient for the initiation of stripe expression, and that both odd-skipped genes and stripe are required downstream of Notch to promote morphological changes associated with formation of long tubular tendons
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Orfanos, Zacharias. "Dynamics of sarcomere assembly in drosophila indirect flight muscles." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533510.

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Cripps, Richard Matthew. "Genetical and biochemical studies of Drosophila indirect flight muscles." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276490.

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Varshney, Gaurav. "Identification of downstream targets of ALK signaling in Drosophila melanogaster /." Doctoral thesis, Umeå : Umeå universitet, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1894.

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Yang, Hairu. "Drosophila skeletal muscles regulate the cellular immune response against wasp infection." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125842.

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Drosophila melanogaster is widely used as a model organism to study the innate immune system because it lacks an adaptive immune response that could mask its innate immune response. The innate immune response of Drosophila primarily consists of humoral and cellular immune responses. The humoral immune response ismediated by antimicrobial peptides, and is induced by bacterial and fungal infections. The cellular immune response is mediated by blood cells (hemocytes), and is induced by bacterial and wasp infection. While the humoral immune response of Drosophila has been studied extensively, the cellular immune response is less well understood. In this work, I investigated the communication between different signaling pathways and tissues in Drosophila during infection by the parasitic wasp Leptopilina boulardi. I find that JAK/STAT signaling is strongly activated by wasp infection, in both hemocytes and (unexpectedly) larval skeletal muscles. This activation is mediated by the cytokines Upd2 and Upd3, which are secreted from circulating hemocytes. Deletion of upd2 or/and upd3 weakens the wasp-induced activation of JAK/STAT signaling in skeletal muscles and the cellular immune response to wasp infection, leading to reduced encapsulation of wasp eggs and a decrease in the number of circulating lamelloyctes. The suppression of JAK/STAT signaling also significantly weakens the cellular immune response in skeletal muscles, but not in fat bodies and hemocytes. However, the activation of this signaling in skeletal muscles has no obvious effect on the cellular immune response. Together, these results suggest that rather than being uninvolved bystanders, Drosophila skeletal musclesactively participate in cellular immune responses against wasp infection. To answer how Drosophila larval muscles participate cellular immune response, I min-screened the effects of several immune related signaling pathways in the muscles and the fat body on the cellular immune response. Interestingly, the cellular immune response was only significantly compromised by the suppression ofinsulin signaling in skeletal muscles, in a way that was veryreminiscent of the phenotypes induced by suppressing JAK/STAT signaling in muscles. While wasp infection activates JAK/STAT signaling in muscles, it has the opposite effect on insulin signaling. In addition, I find that insulin signaling in skeletal muscles can positively regulate JAK/STAT signaling. On the other hand, suppression of JAK/STAT signaling in muscles reduces insulin signaling locally in muscles and systemically in the fat body. Suppression of either insulin or JAK/STAT signaling in muscles leads to reductions in glycogen storage in muscles, the trehalose concentration in the hemolymph, and the frequency of feeding behavior. All these results indicate that JAK/STAT and insulin signaling in Drosophila skeletal muscles regulate cellular immune responses via their effects on carbohydrate metabolism. Our findings shed new light on the interactions between diabetes, metabolism, the immune system, and tissue communication.
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Shirinian, Margret. "Midgut and muscle development in Drosophila melanogaster." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22137.

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The fully developed and functional Drosophila midgut comprises two layers, the visceral mesoderm and the endoderm. The visceral muscle of the midgut is formed by the fusion of founder cells with fusion competent cells to form the muscle syncytia. The specification of these cells and thus the fusion and the formation of the midgut muscle is dependent on the  Receptor tyrosine kinase (RTK) Alk (Loren et al., 2003). The endoderm underlies the visceral muscle and is formed from cells that originate from the anterior and the posterior parts of the embryo. These cells use the visceral mesoderm as a substrate for their migration. Using Alk mutant animals, we have studied endoderm migration during embryonic development. While the initial migration of the endoderm is not affected in the absence of the visceral mesoderm, we observe that the later dorsal-ventral endodermal migration does not take place. The development of the visceral muscle and its dependence on the endoderm is poorly understood.  We have analysed gürtelchen (gurt) mutant animals, originally identified in a genetic screen for mutations affecting visceral muscle formation. Gurt mutants are so named due to their belt-like phenotype of the visceral muscle (gürtelchen is German for belt). Mapping of the genomic locus identified gurt as a mutation in a previously described gene - huckebein (hkb) which is known to have an important function in endoderm development. Gurt (hkb) mutants were used to further study the interaction between the endoderm and the visceral muscle during development. The initial specification of founder cells and fusion competent myoblasts as well as fusion events are unaffected in gurt (hkb) mutants, however, the elongation and stretching of the visceral muscle does not proceed as normal. Moreover, ablation of the visceral mesoderm disrupts endoderm migration, while ablation of the endoderm results in a delayed disruption of visceral muscle formation. Signaling between the two tissues was investigated in detail. Since Alk is a critical player in visceral muscle development, we employed Alk mutant embryos for this task. In addition to the role of Alk in specifying the founder cells and initiating the visceral muscle fusion, we have shown that Alk mediated signaling has a role in the induction of the midgut constriction process by regulating dpp expression in the developing embryonic gut.  Finally, we wished to identify genes in the founder cells/fusion competent myoblasts that might be regulated by Alk. C3G is a gunaine nucleotide exchange factor expressed in the visceral muscle founder cells. Deletion of the Drosophila C3G locus resulted in the generation of null mutants in C3G which are viable, but display decreased longevity, fitness and are semi-lethal. Further analysis of C3G mutants indicated that C3G is essential for normal larval musculature development, in part by regulating integrin localization at muscle attachment sites.
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Islam, Riswana. "The role of [beta]FTZ-F1 in the innervation of the abdominal and pharyngeal muscles in Drosophila /." Connect to online version, 2005. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2005/92.pdf.

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Soler, Cédric. "La formation des muscles de la patte chez Drosophila melanogaster : un nouveau modèle d'étude de la myogenèse appendiculaire." Clermont-Ferrand 1, 2005. http://www.theses.fr/2005CLF1MM20.

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Bernard, Frédéric. "Etude du rôle du gène vestigial au cours de la myogenèse adulte chez Drosophila Melanogaster." Paris 7, 2006. http://www.theses.fr/2006PA077073.

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Drosophila melanogaster est un système modèle particulièrement adapté à la génétique du développement. La facilité d'entretien et de stockage des différentes lignées, une large collection de lignées mutantes à disposition et de nombreux outils génétiques sont les plus gros avantages de ce système d'étude. Chez la drosophile, le thorax contient l'ensemble des muscles nécessaires au vol de la mouche. Parmi ceux-ci on distingue de petits muscles tubulaires qui sont directement attachés à l'aile : les muscles directs du vol (DFM : Direct Flight Muscles) et de plus grands muscles attachés à l'exosquelette cuticulaire qui forme le thorax : les muscles indirects du vol (IFM : Indirect Flight Muscles). La contraction des IFM entraîne des déformations du thorax nécessaires à la synchronisation du battement des ailes. Au laboratoire, il a été isolé un allèle nul du gène (vgnull) qui est associé à des dégénérescences spécifiques des IFM. Le but de ma thèse était « L'étude du rôle du gène vestigial au cours de la myogenèse adulte chez Drosophila melanogaster ». Des expériences de génétique et d'immunohistochimie ont permis de mettre en évidence plusieurs dérégulations génétiques indiquant un rôle de VG dans l'identité du développement des muscles indirects du vol (Indirect Flight Muscles, IFM). Ce rôle se fait en partie en inhibant une identité du développement de type DFM. De plus, j'ai pu montrer que VG est impliquée dans la différenciation musculaire en réprimant la voie Notch, Durant la dernière partie de ma thèse, j'ai étudié la régulation du gène vg au cours du processus myogénique, et j'ai pu identifier une séquence génomique responsable de l'expression musculaire de vg
Drosophila melanogaster is an attractive experimental model System because of its short generation time and the easy handling of the flies. This model also benefit from a wide range of methods for carrying out molecular genetic analysis ; these include transgenesis, controlled gene-overexpression System based on the yeast GAL4-UAS System, and a tool (the Flp-FRT System) for performing site-specific recombination. Flight muscles in Drosophila are located in the thorax and are subdivided into two distinct classes : the Direct Flight Muscles (DFMs) attached to the wing hinge and directly responsible for wing movement, and the Indirect Flight Muscles (IFMs) attached to the cuticule and contributing to flight by deformation of the thorax. The IFMs represent the majority of the thoracic muscles. During my PhD, I was interested in IFM development in Drosophila melanogaster. I focus my work on the function of a mammalian-confserved transcription factor Vestigial - Scalloped (VG-SD) during this process. I have shown that VG is necessary for developmental identity of IFM and that an absence of VG leads to IFM specific degeneration through an apoptotic process. I have also obtained some results involving VG in muscle differentiation through Notch pathway inhibition. Finally, I have studied the régulation of vg gene during this process and I have isolated a genomic sequence responsible for the muscular expression of this gene
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Caine, Charlotte. "Etude des interactions entre MEF2 et la voie de signalisation Notch au cours de la myogenèse adulte chez Drosophila melanogaster." Paris 7, 2012. http://www.theses.fr/2012PA077248.

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La myogenèse des muscles indirects du vol (IFM) chez Drosophila melanogaster suit un schéma développemental précis. Au cours de l'embryogenèse, un groupe de cellules, les Précurseurs adultes Musculaires (AMP) se spécifient. Ces cellules deviennent des myoblastes qui prolifèrent au cours des stades larvaires et donneront par la suite les IFM adultes. Nos travaux se sont concentrés sur les interactions requises lors de la transition de myoblastes qui prolifèrent au statut de myoblaste différencié prêt à fusionner à la fibre musculaire. Il a été montré que les myoblastes qui prolifèrent ont une voie Notch active et que cette voie est inhibée dans les fibres en cours de différenciation. De plus, il a également été montré que les facteurs de transcription Myocyte Enhancer Factor 2 (MEF2), Vestigial (VG) et Scalloped (SD) sont nécessaires pour le développement des IFM et que VG est requis pour la répression de la voie Notch dans les fibres. Cette étude porte sur les interactions entre la voie Notch et MEF2 et les mécanismes mis en jeu pour réprimer la voie au cours de la différenciation. Nous avons montré que MEF2 peut réprimer la voie Notch dans des contexgtes non-musculaires. En utilisant un crible récent pour identifier des cibles potentielles de MEF2, nous avons cherché ceux qui sont également des cibles de SD. Parmi les résultats, deux cibles ont présenté un intérêt particulier, Delta et neuralized, deux composants de la voie de signalisation Notch. Nos résultats montrent dans un contexte ex vivo que les séquences enhancers de DI et neur sont régulées par MEF2/SD et MEF2/NOTCH respectivement. In vivo ces enhancers sont actifs dans les fibres des IFM en cours de différenciation pour DI et au cours de la différentiation tardive pour neur. Au cours de ma thèse, j'ai pu étudier l'effet de MEF2 sur la régulation de ces cibles pour comprendre leur rôle au cours de la différentiation des IFM
Myogenesis of indirect flight muscles (IFM) in Drosophila melanogaster follows a well defined cellular developmental scheme. During embryogenesis, a subset of cells, the Adult Muscle Precursors (AMPs), are specified. These cells will become proliferating myoblasts during the larval stages which will then give rise to the adult IFM. Our work focused on the interactions required during the transition between proliferating myoblasts to differentiated myoblasts ready to fuse to the muscle fiber. It has been previously shown that proliferating myoblasts express the Notch pathway, and that this pathway is inhibited in developing muscle fibers. On the other hand, it has also been shown that the Myocyte Enhancing Factor 2 (MEF2), Vestigial (VG) and Scalloped (SD) transcription factors are necessary for IFM development and that VG is required for Notch pathway repression in differentiating fibers. Our study focuses on the interactions between Notch and MEF2 and mechanisms by which the Notch pathway is inhibited during differentiation. Here we show that MEF2 is capable of inhibiting the Notch pathway in non myogenic cells. A previous screen for MEF2 potential targets identified Delta and Neuralized, two components of the Notch pathway. Both are expressed in developing fibers where MEF2, SD and VG are expressed. Our preliminary results show that MEF2 is required for Delta expression in developing IFMs and that this regulation is potentially dependent on an enhancer to which MEF2 and SD bind. We have identified a similar neuralized enhancer that seems to be potentially regulated by MEF2 and NICD. During my thesis I studied the effect of MEF2 on these targets in vivo and in vitro to understand the rote they play during IFM differentiation
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Books on the topic "Drosophila muscles"

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Helen, Sink, ed. Muscle development in drosophila. Georgetown, Tex: Landes Bioscience/Eurekah.com, 2006.

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Garcia, Christian Joel. The Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles. [New York, N.Y.?]: [publisher not identified], 2020.

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Nature's versatile engine: Insect flight muscle inside and out. Georgetown, Tex: Landes Bioscience/Eurekah.com, 2006.

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Sink, Helen. Muscle Development in Drosophila. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/0-387-32963-3.

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Bost, Alyssa. An Investigation into the Function and Specification of Enteroendocrine cells in Drosophila melanogaster and Mus musculus. [New York, N.Y.?]: [publisher not identified], 2013.

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Muscle development in drosophila. Georgetown, TX: Landes Bioscience / Eurekah.com, 2006.

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Sink, Helen. Muscle Development in Drosophilia. Springer, 2010.

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Sink, Helen. Muscle Development in Drosophilia. Springer, 2006.

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Sink, Helen. Muscle Development in Drosophilia. Springer London, Limited, 2006.

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Merritt, Thomas J. S. Regulation of the development of sex-specific genital muscles by the doublesex gene. 1994.

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Book chapters on the topic "Drosophila muscles"

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Vigoreaux, Jim O., Jeffrey R. Moore, and David W. Maughan. "Role of the Elastic Protein Projectin in Stretch Activation and Work Output of Drosophila Flight Muscles." In Advances in Experimental Medicine and Biology, 237–50. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4267-4_14.

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Van Doren, Mark. "Development of the Somatic Gonad and Fat Bodies." In Muscle Development in Drosophila, 51–61. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/0-387-32963-3_5.

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Lavergne, Guillaume, Cedric Soler, Monika Zmojdzian, and Krzysztof Jagla. "Characterization of Drosophila Muscle Stem Cell-Like Adult Muscle Precursors." In Methods in Molecular Biology, 103–16. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6771-1_5.

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Morriss, Ginny R., Anton L. Bryantsev, Maria Chechenova, Elisa M. LaBeau, TyAnna L. Lovato, Kathryn M. Ryan, and Richard M. Cripps. "Analysis of Skeletal Muscle Development in Drosophila." In Methods in Molecular Biology, 127–52. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-343-1_8.

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Puppa, Melissa J., and Fabio Demontis. "Skeletal Muscle Homeostasis and Aging in Drosophila." In Life Extension, 107–26. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18326-8_5.

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Molloy, Justin, Andrew Kreuz, Rehae Miller, Terese Tansey, and David Maughan. "Effects of Tropomyosin Deficiency in Flight Muscle of Drosophila Melanogaster." In Mechanism of Myofilament Sliding in Muscle Contraction, 165–72. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2872-2_15.

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Kaya-Çopur, Aynur, and Frank Schnorrer. "RNA Interference Screening for Genes Regulating Drosophila Muscle Morphogenesis." In Methods in Molecular Biology, 331–48. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8897-6_20.

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Dubey, Madhavi, Kumari Pragati Nanda, and Hena Firdaus. "Cryodissection and Tissue Preparation of Drosophila Thorax for Indirect Flight Muscle Imaging." In Springer Protocols Handbooks, 65–76. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/978-1-4939-9756-5_6.

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Bryantsev, Anton L., Lizzet Castillo, Sandy T. Oas, Maria B. Chechenova, Tracy E. Dohn, and TyAnna L. Lovato. "Myogenesis in Drosophila melanogaster: Dissection of Distinct Muscle Types for Molecular Analysis." In Methods in Molecular Biology, 267–81. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8897-6_16.

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Sullivan, David, Norma Slepecky, and Nicholas Fuda. "Analysis of Co-Localization of Glycolytic Enzymes in Flight Muscle and its Relation to Muscle Function in Drosophila." In Technological and Medical Implications of Metabolic Control Analysis, 223–31. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4072-0_25.

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Conference papers on the topic "Drosophila muscles"

1

Gautam, Rekha, Upendra Nongthomba, Siva Umapathy, P. M. Champion, and L. D. Ziegler. "Raman Spectroscopic Study of Muscles Related Disorders using Drosophila Melanogaster as a Model System." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482584.

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Koppes, Ryan A., Douglas M. Swank, and David T. Corr. "Force Depression in the Drosophila Jump Muscle." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19436.

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The depression of isometric force after active shortening, termed force depression (FD), is a well-accepted characteristic of skeletal muscle that has been demonstrated in both whole muscle [1,3] and single-fiber preparations [1,2]. Although this history-dependent behavior has been observed experimentally for over 70 years, its underlying mechanism(s) remain unknown. Drosophila melangastor, commonly known as the fruit fly, is a well established, comprehensively understood, and genetically manipulable animal model. Furthermore, Drosophila have proved to be an accurate model species for studying muscle mechanics, and the Tergal Depressor of the Trochanter (TDT), or jump muscle, has most precisely resembled the mechanics of mammalian skeletal muscle [4]. Due to the structural and phenomenological similarities of the TDT muscle to skeletal muscle, in addition to the potential use of genetic mutations in fly models, it is extremely advantageous to investigate the presence of history dependent phenomenon in the TDT. If such phenomena are present, further investigation utilizing different myosin and actin isoforms to study the underlying mechanism(s) could produce new insight into this history-dependent phenomenon, otherwise impossible to elucidate using current experimental models. Thus, it is the goal of this study to determine the presence and degree of FD in the TDT muscle of wild type Drosophila.
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Yadav, Kuleesha, Feng Lin, and Martin Wasser. "Muscle segmentation in time series images of Drosophila metamorphosis." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319044.

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Koppes, Ryan A., Douglas M. Swank, and David T. Corr. "Transient and Steady-State Force Enhancement in the Drosophila Jump Muscle." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80455.

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The increase of isometric force after active lengthening, termed force enhancement (FE), is a well-accepted characteristic of skeletal muscle that has been demonstrated in both whole muscle [1,3] and single-fiber preparations [1,2]. The amount of FE increases with increasing amplitudes of stretch, yet no clear correlation between FE and the rate stretch has been demonstrated [2]. Although this behavior has been observed experimentally for over 70 years, its underlying mechanism(s) remain unknown. Furthermore, most studies of FE have been limited to steady-state (FESS) observations [1–3], whereas clues to the underlying mechanism(s) may very well exist in the transient force recovery period following an active stretch, as seen in another history-dependent phenomenon, force depression [4].
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Koppes, R. A., D. M. Swank, and D. T. Corr. "The presence and characterization of Force Depression in the Drosophila jump muscle." In 2011 37th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2011. http://dx.doi.org/10.1109/nebc.2011.5778646.

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Suzumura, K., K. Funakoshi, T. Hoshino, H. Tsujimura, K. Iwabuchi, Y. Akiyama, and K. Morishima. "A light-regulated bio-micro-actuator powered by transgenic Drosophila melanogaster muscle tissue." In 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2011. http://dx.doi.org/10.1109/memsys.2011.5734383.

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Hirooka, Masaya, Sze Ping Beh, Toshifumi Asano, Yoshitake Akiyama, Takayuki Hoshino, Keita Hoshino, Hidenobu Tsujimura, Kikuo Iwabuchi, and Keisuke Morishima. "Evaluation and optical control of somatic muscle micro bioactuator of channelrhodopsin transgenic Drosophila melanogaster." In 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2014. http://dx.doi.org/10.1109/memsys.2014.6765608.

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Greenhalgh, C., R. Cisek, V. Barzda, and B. Stewart. "Dynamic and Structural Visualization of Muscle Structure in Drosophila with Multimodal Harmonic Generation Microscopy." In Biomedical Topical Meeting. Washington, D.C.: OSA, 2006. http://dx.doi.org/10.1364/bio.2006.wf6.

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"Role of Hsp70 chaperones in age-related changes in skeletal muscle proteome in Drosophila melanogaster." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-627.

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Suzumura, Kiyofumi, Kensuke Takizawa, Hidenobu Tsujimura, Kikuo Iwabuchi, Takayuki Hoshino, and Keisuke Morishima. "Performance evaluation of a tiny insect muscle-powered bioactuator using gene modified Drosophila melanogaster's dorsal vessel tissue." In 2010 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2010. http://dx.doi.org/10.1109/mhs.2010.5669558.

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Reports on the topic "Drosophila muscles"

1

Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mutant receptors, cell lines and pheromone glands (at tissue and organism levels) against selected, designed compounds to confirm if compounds are agonists or antagonists. (2) The elucidation ofthemolecular regulationmechanisms of PBAN-R by:(a) age-dependence of gene expression; (b) the effect of hormones and; (c) PBAN-R characterization in male hair-pencil complexes. Background to the topic Insects have several closely related G protein-coupled receptors (GPCRs) belonging to the pyrokinin/PBAN family, one with the ligand pheromone biosynthesis activating neuropeptide or pyrokinin-2 and another with diapause hormone or pyrokinin-1 as a ligand. We were unable to identify the diapause hormone receptor from Helicoverpa zea despite considerable effort. A third, related receptor is activated by a product of the capa gene, periviscerokinins. The pyrokinin/PBAN family of GPCRs and their ligands has been identified in various insects, such as Drosophila, several moth species, mosquitoes, Triboliumcastaneum, Apis mellifera, Nasoniavitripennis, and Acyrthosiphon pisum. Physiological functions of pyrokinin peptides include muscle contraction, whereas PBAN regulates pheromone production in moths plus other functions indicating the pleiotropic nature of these ligands. Based on the alignment of annotated genomic sequences, the primary and secondary structures of the pyrokinin/PBAN family of receptors have similarity with the corresponding structures of the capa or periviscerokinin receptors of insects and the neuromedin U receptors found in vertebrates. Major conclusions, solutions, achievements Evolutionary trace analysisof receptor extracellular domains exhibited several class-specific amino acid residues, which could indicate putative domains for activation of these receptors by ligand recognition and binding. Through site-directed point mutations, the 3rd extracellular domain of PBAN-R was shown to be critical for ligand selection. We identified three receptors that belong to the PBAN family of GPCRs and a partial sequence for the periviscerokinin receptor from the European corn borer, Ostrinianubilalis. Functional expression studies confirmed that only the C-variant of the PBAN-R is active. We identified a non-peptide agonist that will activate the PBAN-receptor from H. zea. We determined that there is transcriptional control of the PBAN-R in two moth species during the development of the pupa to adult, and we demonstrated that this transcriptional regulation is independent of juvenile hormone biosynthesis. This transcriptional control also occurs in male hair-pencil gland complexes of both moth species indicating a regulatory role for PBAN in males. Ultimate confirmation for PBAN's function in the male tissue was revealed through knockdown of the PBAN-R using RNAi-mediated gene-silencing. Implications, both scientific and agricultural The identification of a non-peptide agonist can be exploited in the future for the design of additional compounds that will activate the receptor and to elucidate the binding properties of this receptor. The increase in expression levels of the PBAN-R transcript was delineated to occur at a critical period of 5 hours post-eclosion and its regulation can now be studied. The mysterious role of PBAN in the males was elucidated by using a combination of physiological, biochemical and molecular genetics techniques.
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