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1
Kaminski, Elizabeth Ann. "Listening to drag music, performance, and the construction of oppositional culture /." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1060196344.
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Thesis (Ph. D.)--Ohio State University, 2003.Title from PDF t.p. (viewed on Apr. 30, 2006). Advisor: Vincent Roscigno, Dept. of Sociology. Includes vita. Includes bibliographical references (p. 138-150).
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Villanueva, Jordán Iván. "“You better werk.” Camp representations of Rupaul’s Drag Race in Spanish subtitles." Consortium Érudit, 2015. http://hdl.handle.net/10757/615516.
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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Condragulations, fierce, realness, werk or «Shante, you stay» are only some of the expressions from the contestants’ lexicon of RuPaul’s Drag Race (RPDR), a popular reality television show that started airing in 2009 in the USA. Through an academic lens, the study of this type of expression was anecdotally called “lavender linguistics,” during the first explorations of the sexual minorities’ ways of talking. Since then and till now, concepts related to gender, sexuality, and the works of representation have influenced both linguistics and Translation Studies, which in turn has led to critical perspectives on translation, identity transfer, acculturation and, of course, the way language works. This paper begins by briefly referring to drag queens living in Lima, Peru, and how they have changed the way they talk to each other and about themselves. As will be argued, a cultural product such as RPDR and the necessary interlingual subtitling into Spanish –commercial or fan-made– have been influencing their linguistic engagement. Further on, the concepts of camp and camp talk will be presented as they were first introduced to Translation Studies with the work of Keith Harvey during the late 1990’s. Camp representations will be then analyzed in commercial and fan-made subtitles to reveal the semiotic and pragmatic constraints resulting from cultural-specific gay identities. From this first approach, new inquiries on audiovisual translations in general and identity acculturation in particular will be proposed.
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Gilburt, Simon John Arthur. "Psychopharmacological aspects of short-term information processing." Thesis, University of Leeds, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277353.
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Song, Dae Hyun. "Pre-Production, Production and Post-Production on Short Film "Draw Me Invisible"." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321962.
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Wuitschik, Georg. "Oxetanes in drug discovery /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17929.
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Petersson, Maria. "Short- and long-term cardiovascular and behavioural effects of oxytocin : mechanisms involved and influence of female steroid hormones /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3503-3.
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Ullman, Carl Fredrik Michael. "Measuring and increasing productivity in drug discovery /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17877.
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Burgess, John Robert Martin E. Davis. "Efficacy of long-term and short-term residential substance abuse treatment modalities." Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Fall/Thesis/BURGESS_JOHN_18.pdf.
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Nebel, Sibylle F. "The role of DNA mismatch repair in drug resistance /." [S.l.] : [s.n.], 1998. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12553.
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Gengler, Malou. "Reductively degradable poly(ethylene glycol) nanoparticles for intracellular drug delivery /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17501.
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Aaro, Martina. "Polypharmacy and Inappropriate Drug Use among Elderly Patients admitted to a Short-Term Nursing Home in Örebro." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-55169.
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Gonzalez, Raul. "The Paced Auditory Serial Addition Test (PASAT) as a measure of working memory : modified scoring guidelines, normative data, and validation /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3130416.
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Vugler, Alexander David. "Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617.
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Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thesis addressed some of these issues by developing short-term mechanistic models of collagen II (CII) immunity. Drug effects on Cll-induced hypersensitivity, anti-CII antibodies and ex vivo CII stimulated CD4⁺ T cell proliferation in mice 14 days post-CII sensitisation were assessed and compared to their anti-arthritic effect in CIA.
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van, der Westhuizen Jos. "Biological applications, visualizations, and extensions of the long short-term memory network." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/287476.
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Sequences are ubiquitous in the domain of biology. One of the current best machine learning techniques for analysing sequences is the long short-term memory (LSTM) network. Owing to significant barriers to adoption in biology, focussed efforts are required to realize the use of LSTMs in practice. Thus, the aim of this work is to improve the state of LSTMs for biology, and we focus on biological tasks pertaining to physiological signals, peripheral neural signals, and molecules. This goal drives the three subplots in this thesis: biological applications, visualizations, and extensions. We start by demonstrating the utility of LSTMs for biological applications. On two new physiological-signal datasets, LSTMs were found to outperform hidden Markov models. LSTM-based models, implemented by other researchers, also constituted the majority of the best performing approaches on publicly available medical datasets. However, even if these models achieve the best performance on such datasets, their adoption will be limited if they fail to indicate when they are likely mistaken. Thus, we demonstrate on medical data that it is straightforward to use LSTMs in a Bayesian framework via dropout, providing model predictions with corresponding uncertainty estimates. Another dataset used to show the utility of LSTMs is a novel collection of peripheral neural signals. Manual labelling of this dataset is prohibitively expensive, and as a remedy, we propose a sequence-to-sequence model regularized by Wasserstein adversarial networks. The results indicate that the proposed model is able to infer which actions a subject performed based on its peripheral neural signals with reasonable accuracy. As these LSTMs achieve state-of-the-art performance on many biological datasets, one of the main concerns for their practical adoption is their interpretability. We explore various visualization techniques for LSTMs applied to continuous-valued medical time series and find that learning a mask to optimally delete information in the input provides useful interpretations. Furthermore, we find that the input features looked for by the LSTM align well with medical theory. For many applications, extensions of the LSTM can provide enhanced suitability. One such application is drug discovery -- another important aspect of biology. Deep learning can aid drug discovery by means of generative models, but they often produce invalid molecules due to their complex discrete structures. As a solution, we propose a version of active learning that leverages the sequential nature of the LSTM along with its Bayesian capabilities. This approach enables efficient learning of the grammar that governs the generation of discrete-valued sequences such as molecules. Efficiency is achieved by reducing the search space from one over sequences to one over the set of possible elements at each time step -- a much smaller space. Having demonstrated the suitability of LSTMs for biological applications, we seek a hardware efficient implementation. Given the success of the gated recurrent unit (GRU), which has two gates, a natural question is whether any of the LSTM gates are redundant. Research has shown that the forget gate is one of the most important gates in the LSTM. Hence, we propose a forget-gate-only version of the LSTM -- the JANET -- which outperforms both the LSTM and some of the best contemporary models on benchmark datasets, while also reducing computational cost.
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Becker, Benjamin [Verfasser]. "Die Zulässigkeit von Hinauskündigungsklauseln nach freiem Ermessen im Gesellschaftsvertrag : Zugleich eine Besprechung von Russian Roulette-, Texan Shoot Out- und Drag-along-Klauseln / Benjamin Becker." Frankfurt : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2012. http://d-nb.info/1042586047/34.
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Kessler, Ulrich. "Random synthesis and biological characterization of nucleoside analogs - new perspectives for drug discovery /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13592.
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Enz, Michael J. "Estimates of first-mover advantages in markets with relatively short product life cycles : an examination of the DRAM industry /." view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3095243.
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Thesis (Ph. D.)--University of Oregon, 2003.Typescript. Includes vita and abstract. Includes bibliographical references (leaves 91-96). Also available for download via the World Wide Web; free to University of Oregon users.
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Bolling-Sternevald, Elisabeth. "Functional Dyspepsia : Symptoms and Response to Omeprazole in the Short Term." Doctoral thesis, Linköping : Univ, 2003. http://www.ep.liu.se/diss/med/07/92/index.html.
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Meinel, Lorenz. "Engineering of bone and cartilage like tissue at the interface of drug delivery and biomaterials." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Department of Chemistry and Applied Biosciences, 2006. http://e-collection.ethbib.ethz.ch/show?type=habil&nr=25.
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Vurma-Rapp, Ulrike Angelika Susanne. "Resistenz von "Pseudomonas aeruginosa" gegen Betalaktam-Antibiotika : Epidemiologie und molekularbiologische Grundlagen /." Zürich : Juris Druck + Verl. Zürich, 1990. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=9106.
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Finkenzeller, Cornelia [Verfasser], and Ursula [Akademischer Betreuer] Zimber-Strobl. "Patients' acute lymphoblastic leukemia cells show heterogeneous growth behavior and drug sensitivity in vivo / Cornelia Finkenzeller ; Betreuer: Ursula Zimber-Strobl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1126407003/34.
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Nepolo, Ester Ndahekelekwa. "Effects of treatment compliance on treatment outcomes for pulmonary tuberculosis patients on Directly Observed Treatment-short Course in Windhoek District, Namibia." University of the Western Cape, 2016. http://hdl.handle.net/11394/4908.
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Magister Public Health - MPHTuberculosis (TB) is a major health problem worldwide, with an estimated 9 million new cases accounting for an estimated 1.5 million deaths in 2012. Non-compliance with TB treatment has become a major barrier to achieving global TB control targets. Namibia is one of the worst affected countries in Africa with a high case notification rate (CNR) of all forms of TB and relatively low treatment success rate compared to the WHO targets. The study aimed at investigating TB treatment compliance and measuring its association to patient characteristics and treatment outcomes, in determining the effects of compliance on treatment outcomes in Windhoek District. This information is crucial for TB programme management and development of targeted strategies. A quantitative observational analytic study using a retrospective cohort design was adopted. New adult Pulmonary Tuberculosis (PTB) patients treated under DOTS in Windhoek District between 1st January 2013 and 31st December 2013 were included in the study based on specified criteria. Data was collected from the patients TB treatment cards using an extraction tool. Selection and information bias was eliminated by using clearly defined inclusion and exclusion criteria using a pre-tested standardised tool. Statistical analysis using descriptive and analytic statistics was done using Epi Info 7 to determine compliance, treatment outcomes and to measure the associations. Overall treatment compliance (89%), initial phase compliance (97.2%) and continuation phase compliance (88.1%) were reported in the study. Age (OR=4.3 95% CI (1.72 – 9.90), p-value=<0.01) and type of area (OR=0.02 95% CI (1.00 – 1.13), p-value=0.05) were associated with compliance in the continuation phase. Overall, type of area (OR=0.03 95% CI (0.00 – 0.91), p-value=0.04) remains associated with treatment compliance. Treatment success is reported among 86.1% of patients. Poor treatment outcomes are associated with non-compliance in the initial phase ( =49.98, p-value=<0.01), continuation phase ( =98.81, p-value=<0.01) and overall ( =110.02, p-value=<0.01). Overall treatment compliance (89%) although higher than expected was lower than the WHO recommended 90% compliance. Very high compliance (97.2%) were reported in the initial phase of treatment whilst compliance was also lower than desired (88.1%) in the continuation phase. Non-compliance recorded in the continuation phase is in agreement with the literature. Age and type of area are associated with compliance as reported in the continuation phase and overall in this study is new contribution of knowledge. The findings suggest that treatment compliance is associated with treatment success in both phases of treatment and overall. Low compliance especially in the continuation phase could lead to poor treatment outcomes such as prolonged infections, relapse, high TB mortality and drug resistance leading to increased programme costs. The study concludes that non-compliance results in poor treatment outcomes highlighting the need for interventions that address compliance in all phases but specifically within the continuation phase and amongst those at risk of having reduced compliance such as those in rural areas and young adult patients aged (15 – 34 years). Recommendations to the District Management Team and TB Programme Managers include: identification of measures that promote treatment compliance; support and monitoring of TB patients’ compliance continuously; strengthening CB-DOT by increasing CB-DOT points and enhancing CB-DOT supporters’ capacity as well as strengthening record keeping as a monitoring tool to increase compliance and improve treatment outcomes.
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Wyl, Viktor von. "HIV-1 drug resistance in the Swiss HIV Cohort study : epidemiology and impact on treatment of HIV-infected patients /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17726.
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Jöhri, Stephan. "Portfolio optimization with hedge funds Conditional value at risk and conditional draw-down at risk for portfolio optimization with alternative investments /." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Department of Computer Science, 2004. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=127.
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Alkoles, Omar M. S. "Mechanical behaviour and fracture toughness of unfilled and short fibre filled polypropylene both drawn and undrawn. Experimental investigation the effect of fibre content and draw ratio on the mechanical properties of unfilled and short glass fibre filled polypropylene." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5510.
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The goal of this research is to investigate the combined effects of glass fibre reinforcement and molecular orientation in polypropylene-short glass fibre composites. Specimens have been fabricated using the injection moulding process and drawn using a small die drawing rig. The effects of die drawing on the fibre composites are complex, with the drawing process orienting both the polymer molecules and the glass fibres. This may be accompanied by the creation of voids in the polymer matrix and their destruction in the compressive stress field thus restoring the interfacial contact area between fibre and matrix. Unfilled and short glass fibre filled polypropylene specimens, with fibre content 7% wt, 13%wt, 27%wt, and 55%wt, were injection moulded prior to the die drawing process. An experimental program of die drawing within an oven at elevated temperature was conducted for polypropylene filled to various levels and at different strain rates. The specimens drew to draw ratios in the range ¿=1.41 to ¿=5.6. Mechanical characterization of the test materials has been conducted by examining the tensile stress strain and fracture behaviour under uniaxial conditions. The influence of glass fibre content and drawing conditions (draw ratio) on the fracture toughness and crack propagation was investigated using the double edge notched fracture test. The notch lengths ranged from 1.5 to 2.5 mm for 10 mm wide specimens. The critical stress intensity factor increased as the fibre content increased up to a limiting filler level. The fracture toughness of both unfilled and fibre filled polypropylene were found to be highly dependent on draw ratio. The results were analysed to find out the optimal draw ratio and fibre content that yielded the maximum modulus, strength and fracture toughness. Data showed that, at a given draw ratio, modulus, strength and fracture toughness increased with increasing fibre content to a maximum and then decreased. The optimum material was obtained at a draw ratio of 2.5 and filler loading 13wt%.
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Gao, Wenwen. "Functional profiling of rare GLP-1R variants, an important drug target gene of type 2 diabetes." Thesis, Université Paris Cité, 2020. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2572&f=24498.
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Le récepteur du glucagon-like peptide-1 (GLP-1) (GLP-1R) est un récepteur couplé aux protéines G de classe B et une cible médicamenteuse importante dans le traitement du diabète de type 2 (DT2)The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) is a class B G protein-coupled receptor and an important drug target in the treatment of type 2 diabetes (T2D)
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Shauli, Mathulo Mathabiso. "Histopathology induced by a medicinal plant indigenous to South Africa that has shown in vitro anti-microbial activity against drug resistant strains of Mycobacterium tuberculosis." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/3990.
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Tuberculosis (TB) still remains a health problem globally with over a million new infections and a mortality rate of 1.5 million individuals annually (Hawn et al., 2014). The emerging multi-drug resistant (MDR) strains that accompany human immune deficiency virus (HIV) infection in high-incidence populations contribute significantly to the health burden of TB (Areeshi et al., 2014). The standard treatment that is advocated by the World Health Organization (WHO) for active tuberculosis includes long-term therapy that incorporates the use of isoniazid, rifampicin, pyrazinimide and ethambutol as front line drugs (WHO, 2013). Drug resistance against established treatment options for TB makes research into new forms of therapy an imperative in health care (Ntulela et al., 2009). South Africa is currently witnessing a high number of cases of drug-resistant TB. In some parts of the country, one in ten cases of TB is resistant to treatment. It is therefore essential to have new anti-tuberculosis agents, which can be readily and simply produced from some local source (Warner et al., 2014). A logical starting point for this research of new agents would be the herbal medicines which have been used for centuries in rural areas by local healers. Western developed countries have harvested ethno botanical knowledge and have produced drug therapies for conventional medicines for other ailments. The activity of extracts of the active plants and their properties still require study in animal models in order to assess their future as new anti-tuberculosis agents (Lall and Meyer, 1999). This study focuses on qualitative and quantitative experimental findings after the administration of a medicinal plant extract to animals. This will include daily observation of animals, recording of feed consumption, recording of animal weights, macroscopic examination of animals at necropsy, tissue harvesting, histological procedures and microscopy.
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Alkoles, Omar M. "Mechanical behaviour and fracture toughness of unfilled and short fibre filled polypropylene both drawn and undrawn : experimental investigation of the effect of fibre content and draw ratio on the mechanical properties of unfilled and short glass fibre filled polypropylene." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5510.
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The goal of this research is to investigate the combined effects of glass fibre reinforcement and molecular orientation in polypropylene-short glass fibre composites. Specimens have been fabricated using the injection moulding process and drawn using a small die drawing rig. The effects of die drawing on the fibre composites are complex, with the drawing process orienting both the polymer molecules and the glass fibres. This may be accompanied by the creation of voids in the polymer matrix and their destruction in the compressive stress field thus restoring the interfacial contact area between fibre and matrix. Unfilled and short glass fibre filled polypropylene specimens, with fibre content 7% wt, 13%wt, 27%wt, and 55%wt, were injection moulded prior to the die drawing process. An experimental program of die drawing within an oven at elevated temperature was conducted for polypropylene filled to various levels and at different strain rates. The specimens drew to draw ratios in the range γ=1.41 to γ=5.6. Mechanical characterization of the test materials has been conducted by examining the tensile stress strain and fracture behaviour under uniaxial conditions. The influence of glass fibre content and drawing conditions (draw ratio) on the fracture toughness and crack propagation was investigated using the double edge notched fracture test. The notch lengths ranged from 1.5 to 2.5 mm for 10 mm wide specimens. The critical stress intensity factor increased as the fibre content increased up to a limiting filler level. The fracture toughness of both unfilled and fibre filled polypropylene were found to be highly dependent on draw ratio. The results were analysed to find out the optimal draw ratio and fibre content that yielded the maximum modulus, strength and fracture toughness. Data showed that, at a given draw ratio, modulus, strength and fracture toughness increased with increasing fibre content to a maximum and then decreased. The optimum material was obtained at a draw ratio of 2.5 and filler loading 13wt%.
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Murano, Maria Cristina. "Critical Paediatric Bioethics and the Treatment of Short Stature : An Interdisciplinary Study." Thesis, Paris, EHESS, 2019. http://www.theses.fr/2019EHES0043.
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Plusieurs études soutiennent qu'il existe une corrélation entre la petite taille et des expériences de vie négatives, telles que la discrimination sociale et des désavantages économiques (en particulier chez les hommes). Il est aujourd’hui possible de traiter par l’hormone de croissance (GH) les enfants petits par rapport à la taille moyenne, sans cause médicale identifiée, notamment les enfants de petite taille idiopathique (PTI). Les critiques de ce traitement soutiennent qu’il n’existe pas suffisamment de preuves pour parler d’une détresse psychosociale causée par la petite taille et de l’efficacité du traitement par GH pour améliorer le bien-être des enfants. Cette controverse est reproduite dans les évaluations internationales du médicament: alors qu’en 2003 l’agence américaine des produits alimentaires et médicamenteux (FDA) a autorisé la mise sur le marché de la GH pour les enfants de PTI, en 2007 l’agence européenne du médicament (AEM) l’a refusé. Ce travail a deux objectifs : premièrement, il vise à identifier et à analyser les normes, les valeurs et les croyances relatives à la petite taille et à l’utilisation du traitement par la GH chez les enfants de PTI, telles qu’elles ressortent des discussions socioculturelles, philosophiques et réglementaires, aussi bien que des récits d’expériences vécues. Deuxièmement, ce travail se propose d’aborder de manière critique et réfléchie la façon dont ces analyses contribuent aux débats de bioéthique sur l’utilisation du traitement par la GH chez les enfants de PTI. Cette thèse utilise ce qu’on appelle une approche critique en bioéthique pédiatrique, qui combine des analyses philosophiques avec des méthodes empiriques. Ce travail est composé de trois articles. Le premier article propose une compréhension critique de la médicalisation en tant que concept et phénomène, et explore ce que cette compréhension critique apporte aux discussions éthiques sur le traitement par GH des enfants de PTI. Le deuxième article examine les arguments en faveur et contre l’octroi d’une autorisation de mise sur le marché du traitement par GH pour l’indication de PTI, présentés dans des documents sélectionnés de la FDA et de la AEM. Le troisième article examine comment et pourquoi il est nécessaire de tenir compte des expériences vécues dans les discussions bioéthiques et biomédicales sur le traitement par GH des enfants de PTI. Cette recherche contribue ainsi au débat éthique sur le traitement par GH des enfants de PTI, en portant un regard critique sur la perception sociale de la petite taille, en soulignant certains défis éthiques rencontrés par les parties prenantes impliquées à différents niveaux et en abordant des nouvelles perspectives sur la manière de traiter ces problèmes éthiquesSeveral studies argue that there is a correlation between short stature and negative experiences, such as social discrimination, and economic disadvantage (especially for men). It is now possible to use recombinant human growth hormone (hGH) to treat children with idiopathic short stature (ISS), namely children who are shorter than average for unknown medical reasons. Critics argue that there is a lack of evidence of both psychological distress caused by short stature and the efficacy of the treatment in increasing children’s well-being. This controversy is reflected in international drug evaluations: while the Food and Drug Administration (FDA) in the US granted marketing authorisation for hGH for children with ISS in 2003, the European Medicines Agency (EMA) refused it in 2007. The research presented here had two aims: first, to identify and analyse the norms, values and assumptions about short stature and the use of hGH treatment for children with ISS, found within sociocultural, philosophical and regulatory discussions of these, and within narrated lived experiences of short stature. Second, to critically and reflectively discuss how these analyses contribute to bioethical debates on the use of hGH treatment for children with ISS. It employs what it calls a critical paediatric bioethics approach, which combines philosophical analyses with empirical methods. The first article proposes a critical understanding of medicalisation as both a concept and a phenomenon, and explores what insights such critical understanding brings to ethical discussions about hGH for children with ISS. The second article examines the arguments for and against granting marketing authorisation of hGH treatment for the indication of ISS presented in selected documents of the FDA and the EMA. The third article examines how and why attendance to lived experiences of height is needed in bioethical and biomedical discussions of hGH treatment for children with ISS. This research contributes to the ethical debate about using hGH for children with ISS, setting a critical gaze onto the social perception of short stature, highlighting some ethical challenges met by stakeholders involved at different levels, and providing new insights into how to address these ethical issues
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Linke, Mats, and Tobias Saarela. "EFFEKTEN AV VIKTMANIPULERAD UTRUSTNING PÅ DRAGSKOTTSHASTIGHET OCH GREPPSTYRKA I INNEBANDY : EN SEX VECKORS STUDIE PÅ MANLIGA 17-ÅRIGA INNEBANDYSPELARE." Thesis, Högskolan i Halmstad, Biomekanik och biomedicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-15290.
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Innebandy är en växande idrott, som framför allt utövas i Sverige, Finland och Schweiz, men där väldigt lite forskning ännu finns publicerad. Tidigare studier inom ishockey och baseboll har visat att träning med viktmanipulerad utrustning förbättrat bland annat greppstyrka och svinghastigheten av slagträ i baseboll. Annan forskning har visat på att det är en förbättring i det neuromuskulära samspelet snarare än ökad muskelmassa som förbättrat prestationen vid dynamisk motståndsträning. Skotthastigheten anses vara en viktig faktor inom innebandy för prestationen och eftersom det inom baseboll har visats att viktmanipulerad utrustning kan förbättra svinghastigheten så vore det intressant att se om samma resultat kan uppnås inom innebandy. Syftet med studien var att undersöka effekten av innebandyträning med en viktmanipulerad innebandyklubba med avseende på dragskottshastighet och greppstyrka hos manliga innebandyspelare samt undersöka korrelationen mellan dragskottshastighet och greppstyrka. Även testpersonernas subjektiva uppfattning av träningen med den viktmanipuleradeutrustningen undersöktes. Testgruppen bestod av 13 stycken 17-åriga manliga innebandyspelare. Under en sex veckors period genomförde testpersonerna 30 minuter av sin vanliga innebandyträning med den viktmanipulerade klubban (40 gram tyngre) tre gånger i veckan. Dragskotten filmades med en höghastighetskamera (Casio Exilim EX-FH25) med 250 fps och analyserades sedan i Dartfish för att mäta hastigheten. För att fastställa greppstyrkan användes en handdynamometer (Jamar – Baseline Hydraulic Hand Dynamometer). Träningen resulterade i en signifikant skillnad hos testpersonernas greppstyrka i den nedre handen på klubban (p<0,05). Däremot hittades ingen signifikant skillnad för den övre handens greppstyrka eller dragskottshastigheten. Studien visade heller inte på någon korrelation mellan dragskottshastighet och greppstyrka hos testpersonerna. Testpersonerna hade olika åsikter kring hur den extra tyngden påverkade innebandytekniken.De funna resultaten indikerar att träning med viktmanipulerad utrustning i innebandy signifikant förbättrar spelarnas greppstyrka i den nedre handen. Den ökade kraftutvecklingen kan eventuellt förklaras av ett ökat neuromuskulärt samspel. Studien ger en ökad förståelse för hur dynamisk motståndsträning kan implementeras i den dagliga innebandyträningen, vilket kan tillämpas vid planeringen av träningsprogram.Floorball is a sport with increasing number of participants, which has not been studied extensively according to the literature. Previous studies on ice hockey and baseball have shown that training with weight manipulated equipment improved grip strength and swing speed. Other research has shown that the increased performance with dynamic resistance training rather occurs from the improvements in the neuromuscular facilitation than an increase in muscle mass. In floorball shooting velocity is considered to be an important factor of the performance. Since it has been shown in baseball that training with weight manipulated equipment can improve the bat velocity, it would be interesting to see if the same results can be found in floorball. The purpose of this study was to investigate the effect of grip strength and drag shot velocity in floorball training with a weight manipulated floorball stick. The study also investigated the relationship between grip strength and drag shot velocity. The test subjects’ subjective perception about the training method was also investigated. Thirteen 17-year-old male floorball players participated in the study. During a six weeks period the subjects used the weight manipulated equipment during 30 minutes, three times per week during their regular team practice. 40 grams lead tape was attached to the player's equipment to increase the resistance. The drag shots were filmed with a high speed camera (Casio Exilim EX-FH25) at 250 fps. The drag shot velocity was analyzed in Dartfish. To assess grip strength a hand dynamometer (Jamar - Baseline Hydraulic Hand Dynamometer)was used. The training resulted in a significant increase for the subjects’ grip strength in the lower hand on the stick (p <0,05). The study found no significant difference for the upper hand grip strength or drag shot velocity. No correlation between drag shot velocity and handgripstrength among the subjects were found. Conclusion: The results found in this study indicate that training with weight manipulated equipment can significantly improve the player’s lower hand grip strength. The results can eventually be explained by more effective fiber recruitment in the muscles. Studying floorball can contribute to increase the interest in research on floorball and increase the understanding for how dynamic resistance training can be incorporated in daily floorball practice.
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Marouby, Matthieu. "Trois études de processus fractionnaires." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/946/.
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Une première partie concerne la simulation du processus nommé Local Time Fractional Stable Motion (LTFSM). Ce processus, introduit par Cohen et Samorodnitsky en 2006, est défini comme l'intégrale du temps local d'un mouvement brownien fractionnaire par rapport à une mesure aléatoire stable, les deux aléas étant définis sur deux espaces de probabilité indépendants. La méthode repose sur la représentation en série du processus et on obtient un contrôle de l'approximation. Dans une seconde partie, on étudie des processus obtenus comme limite de sommes de micropulsations. Dans ce cas on étudie en particulier le comportement si les "montées" et les "descentes" ne sont pas égales. Enfin, on généralise ces processus à des index multidimensionnels. Les processus limites obtenus sont variés, du mouvement brownien standard à des draps browniens multifractionnaires selon les cas étudiés. Enfin, on étudie un modèle physique correspondant au champ créé par des particules chargées distribuées dans un hyperplan. Le processus limite est fractionnaire, gaussien, centré et, dans certains cas, connu (notamment le mouvement brownien fractionnaire). On étudie ensuite certaines propriétés, comme le nombre de minimum locaux obtenus. Cette partie soulève de nombreuses questions encore ouvertesThe first part is devoted to the simulation of the Local Time Fractional Stable Motion (LTFSM). This process, which was introduced in 2006 by Cohen and Samorodnitsky, is defined as the integration of the local time of a fractional Brownian motion with respect to a random stable measure, the randomness of both objects being defined on two independent probability spaces. Using a series representation method to simulate it, I obtain a control of the approximation. In the second part, I study processes obtained as limits of sums of micropulses, specifically focusing on behavior when "ups" and "downs" of the micropulses are not equal. Then, I generalize the processes obtained to processes with multidimensional indices. Processes obtained in this work vary from standard Brownian motions to multifractional Brownian sheets. Finally, I study a model from physic theory, a field created by charged particles randomly distributed in a hyperplan. The limit process is fractional, centered, Gaussian and in some cases well-known like fractional Brownian motion. Eventually, I study some of its characteristics, such as the number of local minima. This part raises many questions that have yet to be resolved
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Bundy, Christopher. "Big in Japan the novel /." Atlanta, Ga. : Georgia State University, 2009. http://digitalarchive.gsu.edu/english_diss/41/.
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Thesis (Ph. D.)--Georgia State University, 2009.Title from title page (Digital Archive@GSU, viewed July 22, 2010) Sheri Joseph, committee chair; John Holman, Josh Russell, committee members. Includes bibliographical references (p. 38).
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Ghadzi, Siti Maisharah Sheikh. "Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317040.
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Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM. The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. The appropriateness of a study design depends on the MoAs of the anti-hyperglycaemic drug. Depending on if the focus is power to identify drug effect or accuracy and precision of drug effect, the best design will be different. Using insulin measurements on top of glucose has increase the power to identify a correct drug effect, distinguish a correct MoA from the incorrect, and to identify a secondary MoA in most cases. The accuracy and precision of drug parameter estimates, however, was not affected by insulin. A natural diabetes disease progression model was successfully added in a previously developed model to describe parameter changes of glucose and insulin regulation among impaired glucose tolerance (IGT) subjects, with the quantification of the lifestyle intervention. In this model, the assessment of multiple short-term provocations was combined to predict the long-term disease progression, and offers apart from the assessment of the onset of T2DM also the framework for how to perform similar analysis. Another previously published model was further developed to characterize the weight change in driving the changes in glucose homeostasis in subjects with IGT. This model includes the complex relationship between dropout from study and weight and glucose changes. This thesis has provided a first written guidance in designing a study for pharmacometrics analysis when characterizing drug effects, for early phase anti-diabetes drug development. The characterisation of the progression from prediabetes to overt diabetes using pharmacometrics modelling was successfully performed. Both the natural progression and the progression with diet and exercise interventions were quantified in this thesis.
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Muriithi, Paul Mutuanyingi. "A case for memory enhancement : ethical, social, legal, and policy implications for enhancing the memory." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/a-case-for-memory-enhancement-ethical-social-legal-and-policy-implications-for-enhancing-the-memory(bf11d09d-6326-49d2-8ef3-a40340471acf).html.
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The desire to enhance and make ourselves better is not a new one and it has continued to intrigue throughout the ages. Individuals have continued to seek ways to improve and enhance their well-being for example through nutrition, physical exercise, education and so on. Crucial to this improvement of their well-being is improving their ability to remember. Hence, people interested in improving their well-being, are often interested in memory as well. The rationale being that memory is crucial to our well-being. The desire to improve one’s memory then is almost certainly as old as the desire to improve one’s well-being. Traditionally, people have used different means in an attempt to enhance their memories: for example in learning through storytelling, studying, and apprenticeship. In remembering through practices like mnemonics, repetition, singing, and drumming. In retaining, storing and consolidating memories through nutrition and stimulants like coffee to help keep awake; and by external aids like notepads and computers. In forgetting through rituals and rites. Recent scientific advances in biotechnology, nanotechnology, molecular biology, neuroscience, and information technologies, present a wide variety of technologies to enhance many different aspects of human functioning. Thus, some commentators have identified human enhancement as central and one of the most fascinating subject in bioethics in the last two decades. Within, this period, most of the commentators have addressed the Ethical, Social, Legal and Policy (ESLP) issues in human enhancements as a whole as opposed to specific enhancements. However, this is problematic and recently various commentators have found this to be deficient and called for a contextualized case-by-case analysis to human enhancements for example genetic enhancement, moral enhancement, and in my case memory enhancement (ME). The rationale being that the reasons for accepting/rejecting a particular enhancement vary depending on the enhancement itself. Given this enormous variation, moral and legal generalizations about all enhancement processes and technologies are unwise and they should instead be evaluated individually. Taking this as a point of departure, this research will focus specifically on making a case for ME and in doing so assessing the ESLP implications arising from ME. My analysis will draw on the already existing literature for and against enhancement, especially in part two of this thesis; but it will be novel in providing a much more in-depth analysis of ME. From this perspective, I will contribute to the ME debate through two reviews that address the question how we enhance the memory, and through four original papers discussed in part three of this thesis, where I examine and evaluate critically specific ESLP issues that arise with the use of ME. In the conclusion, I will amalgamate all my contribution to the ME debate and suggest the future direction for the ME debate.
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Smith, Evan J. "Down-under drag : inside Australia's drag king and drag queen communities." Thesis, 2014. http://hdl.handle.net/1959.7/uws:36729.
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Down-Under Drag is an ethnographic exploration into the lived experiences of Australian drag queens and drag kings. Drag is a unique performance art that hinges on the notion of cross dressing – where a performer’s presentation of gender, in drag, is not aligned with his or her biological sex. This performance style is predominantly undertaken by gay, lesbian and transgendered individuals as a form of entertainment in gay and lesbian communities and usually involves the adoption of a hyper-masculine or hyper-feminine disguise by the performer. Through methods of interviewing and observation, this thesis offers first-hand information into the experiences of a range of Australian drag performers, undertaking a thematic analysis of a variety of key concepts as emerged from those experiences. Through a grounded theory approach, the analytical exploration of such concepts has informed the theoretical material used to better understand those experiences. Namely, through the application of Butler’s post-structuralist theory of gender performativity (1990), this thesis views gender as social construct, created and maintained through the repetition of various stylized acts. With the help of Butler (1990, 2004) I will argue that drag performers take up multiple, shifting and contradictory gendered subjectivities. As most academic literature available in this area of study deals primarily with drag king and queen cultures in isolation, the aim of this thesis is to analytically compare these performance cultures and the roles their performers take up as entertainers and socialisers within Australian gay communities. I will demonstrate that these performers use the medium of drag most frequently as a tool for critique - particularly concerning normative constructs of sex and gender- and also as a tool to pay homage to those constructs. This thesis will argue that practices of drag create a persistent and productive tension between the forces of subversion and the forces of normativity.
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Feng, Z. "Development of short-chain quinones." Thesis, 2021. https://eprints.utas.edu.au/46121/1/Feng_whole_thesis.pdf.
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Mitochondrial dysfunction leads to rare mitochondrial diseases but is also present in a vast number of common disorders such as glaucoma and diabetes. Despite the large number of affected patients, there is a striking unmet medical need for pharmacological approaches that directly target mitochondrial function. For this purpose, short-chain quinones (SCQs) have been widely investigated as potential therapeutic molecules for mitochondrial diseases and related disorders. To date, only the synthetic benzoquinone idebenone has been clinically approved in limited countries for a single mitochondrial disease, Leber’s hereditary optic neuropathy (LHON). Although idebenone consistently shows very good safety and efficacy against vision loss in some LHON patients, its activity is limited by its rapid metabolic inactivation. To overcome these significant limitations, a library of novel SCQs was designed and synthesized at the University of Tasmania. From this panel, some compounds showed significantly improved cytoprotective activity in vitro compared to idebenone under conditions of mitochondrial dysfunction in the human hepatocarcinoma cell line HepG2. To identify the most promising SCQs from this novel library to aid its further development against mitochondrial diseases and related disorders, the current project aimed to characterize in vitro bioactivity, metabolic stability and toxicity profiles as well as in vivo therapeutic efficacy for selected candidate molecules. An in vitro bioactivity profile for 103 SCQs was generated that assessed metabolism related markers, redox activity, expression of cytoprotective proteins and oxidative damage in HepG2 cells. Cytoprotection by SCQs in the presence of rotenone was observed to be correlated with the NAD(P)H:quinone oxidoreductase 1 (NQO1)-dependent reduction of SCQs, which suggests an unexpected mode of action for SCQs that appears to involve a modification of NQO1-dependent signaling rather than a protective effect by the reduced quinone itself. Subsequently, a simple and efficient reverse-phase liquid chromatography (RP-LC)-based method was developed to determine the metabolic stability of the 16 most cytoprotective SCQs in HepG2 cells. In this assay, 15 SCQs, showed significantly higher metabolic stability than idebenone. Furthermore, detailed toxicity profiles were generated for the 11 best SCQs that displayed enhanced cytoprotection and improved metabolic stability. Compared to idebenone, lower metabolic toxicity, lower toxicity with regards to membrane integrity, lower long-term toxicity, as well as an absence of mitochondrial toxicity, pyknosis, DNA damage, or transformation potential were identified for different SCQs to different extents. Lastly, two novel SCQs identified with enhanced cytoprotection, improved metabolic stability, absence of mitochondrial toxicity or transformation potential were assessed for their protective activity in a rat model of diabetic retinopathy. Both compounds, given topically as eye drops, showed superior activity to restore vision in this pre-clinical model compared to the reference compounds idebenone and elamipretide. Unfortunately, due to aberrant animal housing conditions, the study was unable to demonstrate systemic therapeutic efficacy in this model. Overall, the results described in this thesis rationalize the selection of development candidates from a range of novel SCQs and inform their further development towards their clinical use.
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Su, Sheng-Bin, and 蘇聖斌. "Aerodynamic Drag of a Droplet with Short-Range Drop-Drop Interaction － Renormalized Droplet Theory." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/89029550054005632382.
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碩士國立成功大學
航空太空工程學系
81
Renormalized droplet theory is applied to study the influence of convective flow and short range drop-drop interaction on the aerodynamic drag of a droplet. Based on the renormalized droplet theory, the influence of convective flow on the aerodynamic drag of a droplet could be decomposed into five principal mechanisms : (1) the variations in pressure of the flow field, (2) the viscous effects, (3) the variations in momentum of the flow field, (4) the thrust drag of the test droplet caused by droplet vaporization, (5) the effects of unsteadiness. It is found that for a single droplet in hot convective flow, the aerodynamic drag is decreased as the environment temperature is increased. At lower Reynolds number, the aerodynamic drag of a combustion droplet is higher than a vaporizing droplet due to the existence of the envelope flame. As the effects of drop-drop interaction are considered, the aerodynamic drag of the test droplet at lower environment temperature is increased as the number density of field droplets is increased.On the other hand, when the environment temperature is higher, the drag coefficient of the test droplet is decreased as the number density of field droplets is increased.Furthermore,according to the renormalized theory, it is found that the pressure variations dominate the drag coefficient of the test droplet, as the drop-drop interaction effects are considered. The viscous effects are further important as the number density of neighboring droplets is decreased. The variations in momentum of the flow field would produce negative effects on the drag coefficient. As to the thrust drag of the test droplet is almost negligible in our calculation.
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Chistyakova, Anastasia. "Travesti Show: Performativita a Vyjednávání Genderové Identity." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-405296.
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This thesis is concerned with the question of gender identification in drag culture. The research, upon which this work is based, focuses on Czech drag queens that participate in drag (travesti) show in an LGBTQ+ enterprise in Prague. In my research, I have attempted to grasp the motivation of my informants to do drag, their connection to queer culture and the ways in which they create their own aesthetic on stage. With the help of these topics, I approach the problem of their gender identification, both in and out of drag. On the basis of the collected fieldwork material and relevant literature, I problematize gender identification among my informants. On the basis of such identification, I furthermore attempt to demonstrate limitations and shortcomings of the heteronormative framework of gender performativity, gender performance and gender identification in general. Keywords: travesty show, drag, queer, homosexuality, performativity, performance, heteronormativity, gender subversion
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Torres, Luís Henrique Magalhães Ramos. "Exploring a Siamese Neural Network Architecture for One-Shot Drug Discovery." Master's thesis, 2020. http://hdl.handle.net/10316/92189.
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Trabalho de Projeto do Mestrado Integrado em Engenharia Biomédica apresentado à Faculdade de Ciências e TecnologiaAs redes neuronais profundas oferecem um elevado poder preditivo ao ser capazes de inferir as propriedades farmacológicas e atividades biológicas de pequenas moléculas em aplicações para descoberta de fármacos. No entanto, a quantidade de informação supervisionada disponível para treino é escassa e o passo de 'lead-optimization' apresenta um problema de 'low-data', dificultando a descoberta de novos compostos com a atividade terapêutica pretendida e respetivos análogos farmacológicos. Um requisito fundamental é a necessidade de uma grande quantidade de exemplos de treino por classe, o que nem sempre é possível em aplicações para descoberta de fármacos. Estes desafios invalidam o uso de instâncias cujas classes são desconhecidas no treino ou em dados onde o número de classes é elevado e oscila dinamicamente. O grande objetivo deste estudo é otimizar a descoberta de novos compostos partindo de um conjunto reduzido de moléculas candidatas. Assim, propomos uma arquitetura de redes neuronais paralelas implementando uma estratégia de 'one-shot learning', baseada num conjunto de redes neuronais convolucionais (CNNs) capazes de aprender a partir de um dado 'score' de semelhança entre duas moléculas devolvido por uma dada função de similaridade. Aplicando uma estratégia de 'one-shot learning', apenas necessitamos de um reduzido conjunto de instâncias por classe para treino e de um pequeno conjunto de dados e recursos computacionais para a construção de um modelo eficaz na previsão. Os resultados obtidos demonstram que o uso de um conjunto de redes neuronais convolucionais paralelas implementando uma estratégia de 'one-shot learning' conduz à obtenção de desempenhos superiores na previsão de novos compostos comparando com os modelos 'state-of-the-art'. Assim, o modelo proposto permite prever corretamente e com elevada eficácia, novos compostos e respetivos análogos farmacológicos, considerando a escassez de dados biológicos disponíveis para aplicações de descoberta e desenvolvimento de fármacos.
Deep neural networks offer a great predictive power when inferring the pharmacological properties and biological activities of small molecules in drug discovery applications. However, in the traditional drug discovery process, where supervised data is scarce, the lead-optimization step is a low-data problem, making it difficult to find molecules with the desired therapeutic activity and obtain accurate predictions for novel compounds and their pharmacological analogs. One major requirement to ensure the validity of the obtained neural network models is the need for a large number of training examples per class, which is not always feasible in drug discovery applications. This invalidates the use of instances whose classes were not considered in the training phase or in data where the number of classes is high and oscillates dynamically.The main objective of the study is to optimize the discovery of novel compounds based on a reduced set of candidate drugs. We propose a Siamese neural network architecture for one-shot classification, based on Convolutional Neural Networks (CNNs), that learns from a similarity score between two input molecules according to a given similarity function. Using a one-shot learning strategy, few instances per class are needed for training, and a small amount of data and computational resources are required to build an accurate model. The results achieved demonstrate that using a Siamese Deep Neural Network for one-shot classification leads to overall improved performance when compared to other state-of-the-art models. The proposed one-shot Siamese neural network architecture provides an accurate and reliable prediction of novel compounds considering the lack of biological data available for drug discovery tasks.
Outro - This research has been funded by the Portuguese Research Agency FCT, through D4 - Deep Drug Discovery and Deployment(CENTRO-01-0145-FEDER-029266).
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Reveron, Maria Elena 1970. "Short and long-term effects of MDMA exposure in rodents : physiological, behavioral and neurochemical responses." 2006. http://hdl.handle.net/2152/13072.
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Benjamin, Daniela. "The effect of the short term use of Zolpidem MR on poor sleep, daily pain and depression in arthritis patients." Thesis, 2015. http://hdl.handle.net/10539/17443.
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A dissertation submitted to the Faculty of Health Science, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science in medicine.
Johannesburg 2014Introduction: The presence of pain during sleep causes patients with chronic daily pain, such as in Rheumatoid and Osteoarthritis, to experience insomnia, fragmented sleep and an increased number of night-time awakenings. This poor sleep results in an increased sensitivity to pain during the day. The effect of improving sleep on pain, sleep and mood after taking Zolpidem MR was the aim of this study. Methods: 11 patients from Chris Hani Baragwanath Hospital in Soweto South Africa who reported insomnia and daily pain spent 4 weeks in this crossover design, double blinded, placebo controlled study. Week 1- baseline, week 2 and 4 were Intervention weeks – either placebo or Zolpidem MR, week 3 was a Washout week. Data collected included actigraphy, McGill Pain Questionnaire, PSQI, BDI, physical activity questionnaire and daily sleep and pain diaries containing VAS scales for sleep and pain. Results: No significant changes were found in the pain or physical activity levels in any of the patients. Sleep quality, as measured by an isolated PSQI question, was improved by Zolpidem MR (p=0.0075). PSQI was decreased in the final week of the study compared to baseline (8.7 vs. 11.3, p=0.0106) and BDI was lower in week 4 than baseline (7.7 vs. 15.85, p=0.0003), BDI was also lower in week 4 compared to week 2 (7.7 vs. 12.8, p<0.05). However the changes in PSQI and BDI were a result of the order of the weeks, with patients interacting with the researcher and were not due to either Zolpidem MR or placebo. Anecdotal reports include feeling more energised and capable of living life. Conclusion: This study has shown that human interaction is an important component of treatment for insomnia and chronic pain as there is a positive effect on sleep disruption and depression.
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Chen, Po-Ling, and 陳柏伶. ""Shoot first, draw the circle afterwards": Three Formality Problems in Hsia Yu's poetry." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/2wk7b7.
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博士國立清華大學
中國文學系
101
Abstract Unlike the common practice of thesis writing, this dissertation expresses my thought on Hsia Yu's poetry with the manner of self-indulging and self-destruction. It does not come with a literature review section and ground itself with theories. Even the conclusion is also very dubious. Under this kind of post-modern condition that everything is abandoned and not picked up again, I wholeheartedly investigate the poetic variation and revolution in Hsia Yu's poem and persistently write down the aesthetic blueprint and imagination in Hsia Yu's another poem. Thus, three unintended and self-enclosing pseudo-poetic terminologies appear: broken musicality, translatedness, and virtual onceness. I use these three pseudo-poetic terminologies to witness straightforwardly on the unceasing thinking about production institute of poetics behind Hsia Yu's astonishing form performance. Keywords: Hsia Yu, form, broken musicality, translatedness, virtual onceness
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Provázková, Jana. "Postavení travesti show v mediální kultuře." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-392955.
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The diploma thesis The Role of Travesty Show in Media Culture is concerned with a question if we can find some similarities between the way how media presents travesty show and the way how people think and talk about this kind of entertainment. As a research method I chose qualitative content analysis and questionnaire. Theoretical part focuses on explanation of technical terms, history of homosexuality, queer culture, queer theory, travesty show and history. In practical part I will create concrete codes from qualitative content analysis and from these codes I will make categories. Part of practical part is also a questionnaire. In the end of this thesis I will compare the codes from qualitative content analysis with the answers from the questionnaire. And based on this comparison I will find out if there exist any similarities between the way how media presents travesty show and the way how people think and talk about this kind of entertainment.
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Trenfield, S. J., A. Goyanes, Richard Telford, D. Wilsdon, M. Rowland, S. Gaisford, and A. W. Basit. "3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach." 2018. http://hdl.handle.net/10454/16553.
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YesThree-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate integration into healthcare, non-destructive characterisation techniques are required to ensure final product quality. Here, the use of process analytical technologies (PAT), including near infrared spectroscopy (NIR) and Raman confocal microscopy, were evaluated on paracetamol-loaded 3D printed cylindrical tablets composed of an acrylic polymer (Eudragit L100-55). Using a portable NIR spectrometer, a calibration model was developed, which predicted successfully drug concentration across the range of 4–40% w/w. The model demonstrated excellent linearity (R2 = 0.996) and accuracy (RMSEP = 0.63%) and results were confirmed with conventional HPLC analysis. The model maintained high accuracy for tablets of a different geometry (torus shapes), a different formulation type (oral films) and when the polymer was changed from acrylic to cellulosic (hypromellose, HPMC). Raman confocal microscopy showed a homogenous drug distribution, with paracetamol predominantly present in the amorphous form as a solid dispersion. Overall, this article is the first to report the use of a rapid ‘point-and-shoot’ approach as a non-destructive quality control method, supporting the integration of 3DP for medicine production into clinical practice.
Open Access funded by Engineering and Physical Sciences Research Council United Kingdom (EPSRC), UK for their financial support (EP/L01646X).
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Chen, Minhua. "Nanotechnology for efficient delivery of short therapeutic oligonucleotides (antisense ODN and siRNA) and codelivery with chemical anticancer drugs for effective cancer therapy." 2009. http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051294.
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Peng, ChueiHsin, and 彭垂星. "The Study of Using Excel VBA to Construct Short-term Production Schedule in the Final Testing of DRAM FactoryScheduling in the Final Testing of DRAM Factory." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/25070247160831358039.
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碩士中華大學
科技管理研究所
93
DRAM has the characters of high investment, high risk, high return rate, and high international competition. In Taiwan, DRAM is mainly a foundry industry. The product specification is controlled by the foreign software or hardware design house, and the market sale is limited in the overseas channels. Facing the price competitions among the Japan, Korea and etc, in addition. As the down-stream of the DRAM industry, the major profit is customers’ orders. Besides, the order profit is based on the customers’ demands of the high quality, quick delivery, and in-line process capability. The DRAM final testing factories must absorb the delay coming from the variation of pre-process, face the pressure of delivered on time or not. As a result, the production scheduling must be flexibility and mobility to meet the customers’ requests. It impacted the managers to adjust the production strategy when the non-anticipation factors (machine down, accepting the rush orders) were happened. Furthermore, it improved the production effectively and increased the competitiveness. The application of using Excel VBA to simulate the trial system is studied in this study. After simulate the process parameters and flexible scheduling, the throughput, productivity efficiency, and WIP stock quantity can be the performance targets. These targets do help the managers to plan the production scheduling, and have been practiced in one professional DRAM factory.
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Lo, Kai-Hsun, and 羅凱薰. "Association of Antiplatelet Drug and Intracerebral Hemorrhage Induce Short Term Mortality – One Regional Hospital in the Northern Taiwan." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75114276155178778732.
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碩士高雄醫學大學
藥學研究所碩士在職專班
98
Intracerebral hemorrhage is cerebral vascular disease, one of the reasons for the cause of acute stroke, the second in Taiwan. In accordance with Department of Health announced the third leading cause of death accounting for 2008. In recent years has made the spontaneous intracerebral hemorrhage treatment guidelines, thus intracerebral hemorrhage as the current emphasis on the question. The prognosis of intracerebral hemorrhage depends on the hematoma location, hematoma volume, glascow coma scale, age and overall health status. The role of previous oral anti-platelet drugs therapy in the intracerebral hemorrhage still remains controversial. To understand the association between the use of antiplatelet drugs and intracerebral hemorrhage-induced short-term mortality, we conducted a retrospective case study and enrolled intracerebral hemorrhage patients who had been diagnosed with ICH from 2006 to 2009 in a regional teaching hospital of northern Taiwan. Among the 197 ICH patients in our study, 70.1% of patients did not use antiplatelet drug and the other 29.9% used antiplatelet drug. The mortality rate after ICH was 4.3% at 3 days, 6.5% at 5 days, 13% at 15 days, and 15.2% at 30 days in the group that did not use antiplatelet drug and 13.6% at 3 days, 15.3% at 5 days, 16.9% at 15 days, and 20.3% at 30 days in the group that used antiplatelet drugs. The adjusted mortality rate based on patients’ alcohol consumption, hemoglobin level, and serum creatinine level was 0.73 ( 95% CI: 0.32-1.70 ) at 3 days, 0.63 ( 95% CI: 0.27-1.49 ) at 5 days, 1.09 ( 95% CI: 0.47-2.56 ) at 15 days, and 0.99 ( 95% CI: 0.45-2.20 ) at 30 days. The study found that the use of antiplatelet drugs and short-term mortality was no correlation, so taking antiplatelet drugs did not increase the short-term mortality of intracerebral hemorrhage.
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"Drug addiction and transference." Tese, MAXWELL, 2006. http://www.maxwell.lambda.ele.puc-rio.br/cgi-bin/db2www/PRG_0991.D2W/SHOW?Cont=8962:pt&Mat=&Sys=&Nr=&Fun=&CdLinPrg=pt.
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Zinchuk, Andrii Mikolayovich, and Yevhenii Sergeevich Tregub. "The role of evidence-based medicine in providing the quality of medical care shown on the example of the Drug Service functioning." Thesis, 2016. http://repo.knmu.edu.ua/handle/123456789/13198.
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Silva, José Diogo Ramalho e. "Drug-induced potentially fatal arrhythmias and sudden cardiac death: a clinical perspective of long QT, short QT and Brugada syndromes." Master's thesis, 2017. https://hdl.handle.net/10216/104358.
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