Dissertations / Theses on the topic 'Douleur dans les médias'
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Roux, Patrick. "Evaluation d'un protocole de diazanalgesie dans le traitement de la douleur en médecine pré-hospitalière au sein du service médical d'urgence de la brigade des sapeurs-pompiers de Paris : à propos de 110 cas." Toulouse 3, 1992. http://www.theses.fr/1992TOU31077.
Full textSTOCLET, MARINE. "Le tramadol dans la douleur." Strasbourg 1, 1995. http://www.theses.fr/1995STR15048.
Full textLévesque, Mylène. "Perception de la douleur dans la schizophrénie : mécanismes excitateurs de la douleur." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6339.
Full textLatreyte, Philippe. "L'association paracétamol - codéine dans la douleur rhumatologique." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M077.
Full textLamouille, Vincent Paille François. "Histoire de la prise en charge de la douleur dans son contexte de savoir et de pensée médicale et sociale." [S.l.] : [s.n.], 2001. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2001_LAMOUILLE_VINCENT.pdf.
Full textNguyen, Hien luong. "Plasticité, métaplasticité synaptique et neuronale dans le cortex somatosensoriel primaire chez le rat dans un modèle de douleur inflammatoire prolongée." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAS027.
Full textChronic neuropathic or inflammatory pain is believed to result from long-lasting synaptic andneuronal changes in pain pathways, including the primary somatosensory cortex (S1) which codes for pain intensity and location. Using ex vivo electrophysiological recordings from S1 layer 2/3 pyramidal neurons, we investigated pain-induced plasticity in a rat model (CFA injection) of chronic facial inflammatory pain. We first establish the relation in basal conditions between synaptic activity and (i) bidirectionalsynaptic plasticity (long-term depression/potentiation; LTD/LTP), (ii) changes in the ability to express synaptic plasticity (metaplasticity), (iii) bidirectional changes in intrinsic neuronal excitability (LTP/LTD-IE); i.e. the rules for synaptic and intrinsic plasticity in S1 layer 2/3pyramidal neurons. We then investigated such plasticity processes in CFA-treated rats exhibiting facial mechanical allodynia, at 1 hour and 3 days post-injection. At 1-hour, mechanical allodynia is associated with (i) LTP of excitatory synaptic transmission, together with (ii) an inhibition to generate further LTP but a facilitation to generate LTD (metaplasticity), consistent with LTP of synaptictransmission, (iii) LTP-IE and (iv) reduced dendritic arbor complexity of S1 layer 2/3 pyramidal neurons. At 3 days, LTP and LTP-IE were still present but metaplasticity and dendritic arbor complexity had returned to control levels
Abou-Nader, Joseph. "La Neurostimulation intériorisée dans le syndrome douleureux : critères et résultats." Montpellier 1, 1988. http://www.theses.fr/1988MON11284.
Full textCHRISTENSEN, DENNIS. "Etudes pharmacologiques dans deux modeles de douleur neuropathique." Paris 6, 2000. http://www.theses.fr/2000PA066107.
Full textNègre-Pagès, Laurence. "Douleur et anxiété dans la maladie de Parkinson." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/367/.
Full textThis work is part of a Toulouse research program on Parkinson's Disease (PD) and in the context of clinical neuro epidemiological activities development. DoPaMiP cross-sectional epidemiological survey aimed to assess the prevalence and associated factors of chronic pain in Parkinson's disease and to compare the clinical profile of PD patients with and without chronic pain. 450 PD patients and 98 non PD patients from the Midi Pyrénées Region were evaluated using validated and standardised questionnaires. From the DoPaMiP survey database, we have been also able to estimate the frequence of anxiety and depression signs using the Hospital Anxiety and Depression Scale (HADS) and to compare clinical features associated with the presence or absence of such anxious or depressive symptoms
Fauconnier, Arnaud. "Diagnostic et physiopathologie des algies pelviennes chroniques dans l'endométriose." Paris 11, 2004. http://www.theses.fr/2004PA11TO02.
Full textGrégoire, Mathieu. "Corrélats comportementaux et neuronaux de l'exposition répétée à la douleur d'autrui dans une perspective de douleur chronique." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27188.
Full textL’estimation de la douleur chez autrui peut être influencée par différents facteurs liés à la personne en douleur, à l’observateur ou bien à l’interaction entre ces derniers. Parmi ces facteurs, l’exposition répétée à la douleur d’autrui, dans les milieux de soins ou dans une relation dans laquelle un des deux conjoints souffre de douleur chronique, a souvent été liée à une sous-estimation de la douleur d’autrui. L’objectif de cette thèse visait à mesurer les impacts de l’exposition répétée à la douleur d’autrui sur l’estimation subséquente de la douleur des autres, mais aussi sur l’activité cérébrale lors de l’observation de la douleur d’autrui et finalement, sur l’estimation de la douleur chez les conjoints de patients atteints de douleur chronique. La première étude expérimentale a permis d’isoler le facteur d’exposition répétée à la douleur d’autrui des autres facteurs confondants pouvant moduler l’estimation de la douleur d’autrui. Ainsi, il a été démontré que l’exposition répétée à la douleur d’autrui diminuait l’évaluation subséquente de la douleur des autres. Dans la seconde étude, il a été démontré en imagerie par résonance magnétique fonctionnelle que l’exposition répétée à la douleur d’autrui entrainait des changements dans l’activité cérébrale de certaines régions associées au traitement affectif (l’insula bilatérale), mais aussi cognitif de la douleur (sulcus temporal supérieur ; précunéus), lors de l’observation de la douleur d’autrui. Finalement, la troisième étude expérimentale, celle-ci proposant une visée plus clinique, a permis de démontrer que les conjoints de patients atteints de douleur chronique ne surestiment pas la douleur de leur conjoint, mais qu’ils perçoivent de la douleur même dans des expressions faciales neutres. L’ensemble de ces résultats suggère que chez les sujets sains, l’exposition répétée à la douleur d’autrui entraine une sous-estimation de la douleur chez l’autre et des changements dans le réseau de la matrice de la douleur lors de l’observation de la douleur des autres. En définitive, ces résultats démontrent que l’exposition répétée à la douleur d’autrui, dans un contexte expérimental, a des impacts majeurs sur l’observateur et son jugement de l’intensité de la douleur.
The estimation of pain in others can be influenced by various factors related to the person in pain, to the observer or the interaction between them. Of these factors, the repeated exposure to the pain of others has often been suggested as one of the factors that could lead to the underestimation of others’ pain, for example in healthcare settings. This thesis aimed to measure the impacts of repeated exposure to the pain of others on the subsequent estimation of others’ pain, but also on the brain activity when observing the pain of others and finally, on the estimation of pain by spouses of chronic pain patients, daily exposed to others pain. The first experimental study isolated the factor of repeated exposure to others’ pain from other confounding factors that may modulate the estimation of the pain in others. Thus, it has been shown that repeated exposure to other people's pain decreased the subsequent estimation of the pain in others. In the second study, it was demonstrated by functional magnetic resonance imaging that repeated exposure to the pain of others led to changes in brain activity in certain regions associated with affective processing (namely the bilateral insula), but also cognitive dimensions of pain (Superior temporal sulcus; precuneus) during the observation of another's pain. Finally, the third experimental study, this one with a more clinical objective, has demonstrated that spouses of chronic pain patients do not underestimate the pain of their spouse, but they do estimate pain when exposed to neutral facial expressions of their loved one. Taken together, these results suggest that repeated exposure to the pain of others leads to an underestimation of others’ pain and changes in the pain matrix network during observation of pain in others. Ultimately, these results demonstrate that repeated exposure to other people's pain, in an experimental setting, has a major impact on the observer and his judgment of the intensity of pain.
Auclair, Vincent. "Régions cérébrales impliquées dans l'encodage mnésique de la douleur." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8832.
Full textO'Reilly, Aminata. "La psychopathologie et les cognitions dans la douleur chronique." Thesis, Toulouse 2, 2012. http://www.theses.fr/2012TOU20036.
Full textChronic pain is often associated with depression and anxiety. These pathologies have complex links that have been widely studied. In France, however, there are few studies that provide information on psychotherapeutic treatment of these patients. The overall objective of this work is to improve understanding of psychopathological and cognitive factors linked to chronic pain. Study 1: A quantitative study was carried out on a sample of 228 students. An analysis of beliefs associated to pain provided insight into the concept of pain sensation. The participants perceived pain as an instable phenomenon over time, were not likely to associate pain with mysterious origins, and did not link pain to feelings of guilt. The results also showed that the participants had rational beliefs about medication, although they tended to believe that medication was overused. Study 2: A quantitative study was conducted on a sample of 247 fibromyalgia sufferers. In this study, 93 % of participants presented depressive symptoms, and 94 % presented anxiety symptoms. Severe depressive symptoms were found in 25 % of cases, and 43 % of participants reported severe anxiety. Regressions analyses showed that the relationship between depressive symptoms, anxiety and pain is partially mediated by beliefs associated with pain.Study 3: A quantitative study was conducted on a sample of 247 people suffering from fibromyalgia. Correlation analyses showed a link between anxio-depressive symptoms, measures related to pain, pain-related beliefs, dramatization, psychological flexibility, and optimism. A multiple regression analysis indicated that beliefs associated with pain, optimism and psychological flexibility predicted 58 % of the variance in scores of dramatization. A cluster analysis highlighted three cognitive profiles in these patients: ‘catastrophics’, ‘moderates’ and ‘flexible optimistics’. Analyses of variance showed that cluster groups differed in levels of depression, anxiety, intensity, and impact of pain. ‘Catastrophics’ had higher scores on these measures
Olié, Emilie. "Douleur psychologique et exclusion sociale dans les conduites suicidaires." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T023/document.
Full textCurrent knowledge suggests that suicidal behavior: 1) are pathological entities per se, with a specific neurobiology, 2) may be studied according to a stress-diathesis model, 3) may be better characterized by identifying biomarkers. Emphasizing that pain is the core of the suicidal process, we propose an outline of a model of suicide based on clinical neuropsychological and neuroimaging data. Psychosocial stressors cause psychological pain. Through dysfunctional vasopressinergic system and cerebral regions involved in social cognitions, psychosocial stress would be maintained or give rise to new stresses, perpetuating or increasing psychache. We suggest a modification of pain thresholds in vulnerable subjects for suicide leading to an increased perception of psychache, which is associated with suicidal ideation. Then, interpersonal difficulties are associated with impaired decision-making underpinned by prefrontal dysfunction that has been associated with suicidal vulnerability. This would cause the subject to promote a choice (suicide) associated with immediate reward (pain relief), although it is associated with deleterious consequences (death). Thus, psychological pain is central to suicidal behavior as an immediate consequence of psychosocial stressors, and influencing the suicidal vulnerability favoring pain perception and increasing susceptibility to social events, based on neuroanatomical and biochemical bases. Finally the hypothesis that a change of pain perception is involved in the suicidal process would open new avenues for understanding suicidal pathophysiology. It allows considering the psychological pain as a potential therapeutic target to prevent suicide
Ratsimba, Rhyco Hasindrainy. "Apport des nouveaux antiépileptiques et des nouveaux antidépresseurs dans le traitement des douleurs neurogènes." Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M049.
Full textCissé, Badara. "L'information locale dans les médias au Sénégal." Bordeaux 3, 1990. http://www.theses.fr/1990BOR30005.
Full textThe local news in senegal remains a monopoly of press establishments, settled by the state according to its regional news policies. That's why the news are in most cases dominated by institution's sources and goes in a single direction from authority to the population
Maatouk, Mustapha. "La publicité dans les médias au Maroc." Paris 2, 1993. http://www.theses.fr/1993PA020058.
Full textLoicq, Marlène. "Médias et interculturalité : l'éducation aux médias dans une perspective comparative internationale (Australie, Québec, France)." Phd thesis, Université de la Sorbonne nouvelle - Paris III, 2011. http://tel.archives-ouvertes.fr/tel-00721174.
Full textLoicq, Marlène. "Médias et interculturalité : l'éducation aux médias dans une perspective comparative internationale (Australie, Québec, France)." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28807/28807.pdf.
Full textJeaugey, Lionnel. "Electrophysiologie de l'Habenula : rôle dans le traitement de l'information nociceptive chez le rat." Grenoble 1, 1991. http://www.theses.fr/1991GRE10030.
Full textKerckhove, Nicolas. "Implication des canaux Cav3.2 dans l'effet antalgique du paracétamol et dans la douleur inflammatoire." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1PP04/document.
Full textAcetaminophen is the most analgesic consumed worldwide, but its mechanism of action is still not understood. Long recognized as non-steroidal anti-inflammatory drugs (NSAIDs), its profile is now reconsidered thanks to the work done over the last ten years. It is now accepted that acetaminophen is an analgesic with a central action and the impact on cyclooxygenase, traditional targets of NSAIDs, is no longer the basis of its mechanism of action. This work show that the analgesic effect of acetaminophen is lost in animals whose Cav3.2 channel has been invalidated, this in various experimental contexts. Thus, these channels appear to be essential for the analgesic effect of acetaminophen. We also demonstrated the nature of that involvement. Indeed, only the brain Cav3.2 channels are involved in the effect of acetaminophen, which joined the previous results showing that acetaminophen is a centrally acting analgesic. In the brain, we also demonstrated that Cav3.2 channels acting in concert with two crucial actors to the effect of acetaminophen: AM404, its active metabolite, and TRPV1 receptors. The purpose of this relationship is the inhibition of Cav3.2 channels that induces analgesic effect of acetaminophen. In parallel, we have demonstrated for the first time that inhibition of brain Cav3.2 channels induced analgesia. This confirms the tonic involvement of these channels in supraspinal pain perception. Finally, we also demonstrated that Cav3.2 channels were heavily involved in the inflammatory pain and, more surprising and interesting, in inflammatory processes associated (edema development and production of pro-inflammatory mediators). Related to these results, we demonstrated that ethosuximide (a Cav3.2 channel blocker) was effective in the treatment of inflammatory pain and inflammation as well as their associated comorbidities (anxiety and depression). In conclusion, the confirmation of the interaction of Cav3.2 channels in the effect of acetaminophen and pain perception opens a new path in understanding the mechanism of action of acetaminophen and in the design and development of new analgesics targeting Cav3.2 channels. This perspective is reinforced by the demonstrations previously done of the role of these channels in the pathophysiology of neuropathic pain. More and interestingly, ethosuximide, an antiepileptic drug used in humans and Cav3 channels inhibitor, allows to consider the realization of a pilot clinical study on the evaluation its antalgic effect. We propose the protocol of this study, proof of concept, performed in a first time in patients of neuropathic pain
Colle, Cyril de. "Pharmacologie des récepteurs métabotropiques du glutamate : implication dans la douleur." Montpellier 2, 2000. http://www.theses.fr/2000MON20131.
Full textCOLOMBANI, JEAN-CHRISTOPHE. "Douleur et plaisir dans leur contexte neurovegetatif : sexualite et oralite." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20258.
Full textDelaunay, Anne. "Rôles et régulations des canaux ioniques ASIC3 dans la douleur." Electronic Thesis or Diss., Nice, 2013. http://www.theses.fr/2013NICE4084.
Full textChronic, inflammatory, neuropathic, or incisional pain is affecting about 20 % of the adult population and up to 50 % of the elderly population. It thus represent a real public health issue. Despite the existence of large families of analgesics, treatments are often ineffective. This is due in large part to a lack of knowledge of the patho-physiological mechanisms of pain. During my PhD, I have been interested in the roles and regulation of molecular sensors of the pain recently highlighted: ion channels (ASICs "Acid Sensing Ion Channels "). ASICs constitute a family of excitatory cationic channels. The ASIC3 channels, in particular, are present in sensory neurons that innervate the skin, muscles, organs and joints. They are activated by low extracellular acidification occurring in many patho-physiological mechanisms such as inflammation, ischemia, tumor growth, or the subsequent tissue damage, for example, surgery. In a first study, we showed that ASIC3 channels play a crucial role in the development of post -operative pain, including postural pain, close to clinical cases. From a plantar incision model in rats, we demonstrated an over-expression of ASIC3 channels in sensory neurons innervating the operated hindpaw. Pharmacological inhibition (with toxin) and invalidation (siRNA) of ASIC3 in vivo reduce pain behavior. Our second study focused on the human ASIC3 channel, not yet extensively studied. I demonstrated that this channel has a unique and inducible property which gives it a sensitivity not only to acidification, but also to the extracellular alkalinization. This alkaline sensitivity is an intrinsic characteristic of the channel. It involves two specific arginine residues in the human channel that are present in its extracellular loop.Thus the human ASIC3 channel adapts its activity at different pH environments, and could participate in the fine regulation of membrane potential and neuronal sensitization. More recently, I have studied the regulation of ASIC3 channel by inflammatory lipids and there effects on pain. Interestingly, I showed that lysophosphatidylcholine (LPC), a lipid produced from the degradation of the membrane during inflammation, is a new activator of ASIC3 channel under normal pH conditions. Moreover, in synergy with moderate acidosis (pH 7.0), the LPC and its non-metabolizable analogue produce spontaneous pain in rats. This pain is reduced in the presence of the ASIC3 inhibitory toxin
Verkest, Clément. "Rôles et régulations des canaux ioniques ASIC1b dans la douleur." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR4039.
Full textAcid-Sensing Ion Channels (ASIC) are trimeric excitatory ion channels activated by extracellular acidification, a phenomenom often encountered in painful pathological diseases. Several members of this family (ASIC1a, ASIC1b, ASIC2a, ASIC2b and ASIC3) can form functional ion channels expressed mainly in the nervous system. Among them, ASIC1b is characterized by its restrain expression in peripheral sensory neurons, responsible for the detection of noxious stimuli. But the implication of ASIC1b in pain has remained elusive for a long time because of the lack of tools needed to study its role. However, the recent identification of mambalgins, a set of peptides extracted from a snake venom and able to block ASIC1a and ASIC1b, has contributed to show for the first time the implication of ASIC1b in acute, inflammatory and neuropathic pain in mice. First, I studied the possible involvement of ASIC1b in migraine. I have shown that in an acute and chronic migraine model in rat, ASIC1a and ASIC1b blockade with mambalgin and amiloride, a non-specific blocker of ASIC channels, abolished the facial and extra-facial cutaneous allodynia, a very common and disabling migraine symptom. Those affects are as effective as the ones induced by the reference migraine treatments. Recurrent blockade of ASIC with mambalgin is able to limit the establishment of cutaneous allodynia related to chronic migraine. Those anti-allodynic effects are fully conserved in ASIC1a Knoc-out mouse in a model of chronic migraine, thus indirectly showing a critical role of ASIC1b. In a second part, I have looked into the possible cellular and molecular mechanisms targeting ASIC1b and explaining its potent implication in pathological pain. I have found that several intracellular signaling pathways are able to positively modulate ASIC1b. Among them, The C-Jun N-terminal Kinases (JNK) was the most promising. JNK potentiates ASIC1b, ASIC3 and heteromeric channels containing at least one of these subunits. ASIC currents obtained from primary culture of sensory neurons are also regulated. Interestingly, JNK regulates rat but not mouse ASIC3, thus making ASIC1b the potential sole target of this regulation in this specie. Thus, my thesis work extends the repertoire of painful pathological diseases where ASIC1b is involved. I have identified the intracellular signaling pathway JNK as a new mechanism of regulation of ASIC and especially ASIC1b. This work provides the first explaination at the molecular level on the mechanisms governing the critical implication of ASIC1b in pain
Delaunay, Anne. "Rôles et régulations des canaux ioniques ASIC3 dans la douleur." Phd thesis, Université Nice Sophia Antipolis, 2013. http://tel.archives-ouvertes.fr/tel-00919428.
Full textLiao, Xiao Ying. "Les medias chinois dans le monde." Paris 2, 1995. http://www.theses.fr/1995PA020107.
Full textIn this thesis called "chinese media in the world". Mrs liao gives us a general description of media in red china and in geographic zones where we may find a chinese diaspora. First of all, mrs liao shows that television has became a massmedia because 800 millions people watch in spite of a real mediocity of its programs. As to the radio, this media is both very common and regionalised and it has been the main factor of the unification of china. Concerning the written press, it has to face the concurence of foreign papers because it has definitively lost. Its image, being a plain propaganda instrument for the c. C. P. Concerning taiwan, hong kong, macao and singapore ad all the chinese media in the other parts of the world, mrs liao writes an analysis which consists a very pragmatic description of quantitative and qualitative factors as : number of titles, number of readers, audience, explained opinions, maintenance of lectorate, radio and television programs. . . In the second part of her thesis of doctorate, mrs liao delivers us an approach of the history of chinese media. She peculiazly shows that chinese papers have been existing since ancient times but began in fact to european like at the end of the 19th century. At the end of the second part we have the description of the characteristics of marxist media after 1949, and of the consequences of the opening of china to occidental countries in 1978. At least in the third part, are described the various problems the chines media have to face today. At the same time mrs liao insists on the political and cultural specificities of all media in contiental china
Zhu, Lichao. "Typologie du défigement dans des médias écrits français." Paris 13, 2013. http://scbd-sto.univ-paris13.fr/secure/ederasme_th_2012_zhu.pdf.
Full textThis work consists in studying the linguistic defreezing phenomenon. We establish three typologies of studying cases chosen from the French satirical weekly newspaper "Le Canard enchaîné". The typologies are made in three parts. The first typology is of structuralism, the second one consists in classifying the defreezing cases by transformations, the last one is a typology of three primary functions of predication. In doing so, we propose different linguistic approaches in treating the problematical defreezing phenomenon, which causes problems in teaching, comprehension and computational linguistic treatment in French
Cardoso, Claudio de Paiva. "Les images dyonysiaques dans le contexte des médias." Paris 5, 1995. http://www.theses.fr/1995PA05H080.
Full textKhalouf-Philippot, Khaoula. "L'image de la Syrie dans les médias français." Paris 12, 2005. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990003941070204611&vid=upec.
Full textThis thesis analyzes what remains constant and what changes in the image of Syria in the French media between the 18th century and the year 2000. This image divides in two: on the one hand, a mythic “imaginary” in literature and, on the other, a mediatized image in the print and visual press. The so-called mediatized image centers on a repressive representation of Syria under French mandate in L'Humanite and Le Figaro in 1939, date at which the sandjak of Alexandrette ceased in Turkey. Then the thesis traces the evolution of this image through the study of the cultural image of Syria in the newspaper Le Monde between 1987 and 1999. The end point of my work on the mediatized image consists of a study of the visual image or Syria on the channel Arte between 1996 and 2000. To conclude this thesis, I study the literary mythic image of Syria and the Arab world in Volney, “Voyage en Syrie et en Egypte,” Maupassant in “Allouma” and Le Clezio in “Poisson d'Or. ”
M'Hamsadji, Takia. "L'image de l'Orient arabe dans les médias américains." Paris 7, 1987. http://www.theses.fr/1987PA070177.
Full textThe aim of this study is to determine the characteristics of the arab stereotype in the american media and its development since the creation of the state of israel in particular. The negative image of the arab world is presented here as the inheritance of orientalism and european colonialism combined with a historical context. The arab-israeli conflict and the oil embargo have brought about a series of "misunderstandings" that strenghened the old fear of islam. The technological advance and the reign of the elctronic era have promoted the propagation of the myth of the orient and enforced an erroneous aspect of the arab civilization and history. Beyond the fixed stage of categorization and prevailing ideology, a new journalism and an awakening of the american public opinion in relation to the american policy towards the middle east have emerged since the 1970, s. This new approach is linked to a better understanding of economic and cultural interdependence between the arab nations and the united states, and to the work of a better organized arab lobby eager to cope with its jewish counterpart. The arab governments and the arab americans have set up a solid organizational structure with thye object of locating and demolishing the arab negative stereotype through an active policy of information on the arab world and an exhaustive use of teh american media. The economic prosperity of the arab orient has allowed a greater pressure to be exerted on the western countries. . .
Happe, Marie-Hélène. "Evaluation de la prise en charge de la douleur dans un service d'accueil et d'urgences d'un centre hospitalier périphérique." Montpellier 1, 1995. http://www.theses.fr/1995MON11043.
Full textHristov, Filip. "L'architecture à travers les médias." Paris 3, 2005. http://www.theses.fr/2005PA030108.
Full textThe presence of the subject " architecture " in the " mass médias " is the principal topic of this work. The research has been done because of the small knowledge of the architectural vocabulary and the lack of understanding of the significance of architecture by most people. By working around thrée principal types of medias : text supports (books, magaznies and e-books), audiovisuals (the radio, the television and the cinema) and the interactif medias (networks, CD-Roms and interactif points) the presence of the subject "architecture " is analyzed in a vast corpus. A close look at the educational role that the medias should play is done by running an analysis of the sort and the amount of architectural knowledge that is transmitted and the advantages and inconvenients of the informationnal supports used
Brennstuhl, Marie-Jo. "Utilisation de la thérapie EMDR - Eye Movement Desensitization and Reprocessing - dans le cadre de la douleur chronique : efficience et perspectives cliniques." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0213.
Full textConsidering the use of EMDR (Eye Movement Desensitization and Reprocessing) therapy is an innovative approach in chronic pain management, this research was divided into three steps.The first part focuses on studying the introduction of the traumatic component as a new aspect of chronic pain. As a multifactorial issue, chronic pain includes four key components, namely sensory, cognitive, behavioural and emotional aspects. In this context, a literature review on comorbidity between chronic pain and post-traumatic stress disorder was carried out.The second step includes a preliminary research on the use of EMDR therapy and an EMDR protocol specifically related to pain, which was pre-tested on three patients. Results of EMDR therapy are encouraging. Clinical findings of traumatic memories which emerged during therapy were used as a basis for the third step.As a result, the main focus of this research was to compare the use of EMDR therapy versus eclectic healthcare in a hospital unit specialized in the management of chronic pain. Forty-five patients divided into three groups were treated by standard protocol of EMDR therapy, pain protocol of EMDR therapy and eclectic therapy. Results show the effectiveness of EMDR therapy on sensory, cognitive, behavioural and emotional but also traumatic components of pain, EMDR standard protocol being most efficient after five sessions, and a reduction of pain extending one month after therapy has been discontinued
SALOU, ESTELLE. "Prise en charge de la douleur dans un service hospitalier de long sejour pour personnes agees." Nantes, 1992. http://www.theses.fr/1992NANT110M.
Full textDébarges, Béatrice. "L'axe hypothalamo-hypophyso-surrénalien dans la fibromyalgie." Mémoire, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/6665.
Full textDelay, Lauriane. "La douleur chronique articulaire dans la polyarthrite rhumatoïde : rôle des canaux ASIC3 dans l'athralgie induite par les ACPA et des voies de signalisation NGF/TrkA dans la douleur chronique inflammatoire." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAS017.
Full textRheumatoid arthritis is an autoimmune disease that affects nearly 1% people worldwide and is characterized by joint inflammation, cartilage and bone damages, associated with chronic joint pain, often resistant to current therapies. Whether at a preclinical stage, where we talk about arthralgia, or at an established stage of the pathology, pain constitutes a real burden for the patients with more than 60% rating their pain management has unsatisfactory. The presence of synovitis is necessary for the diagnosis of established RA, therefore, no real therapeutic strategy is used at a preclinical stage. In addition, at an established stage, the current strategy aimed primarily at reducing the activity of the pathology without an actual management of the pain as such. Among the actors of synovitis in RA, Nerve Growth Factor plays a critical role in the establishment and maintenance of painful symptoms. Anti-NGF are known as promising analgesic drugs. Nevertheless, due to pleiotropic effects of NGF, targeting this neurotrophin leads to significant adverse effects. In the first part of this work, we sought to better characterize the specific involvement of intracellular signaling pathways of the high affinity tyrosine kinase A (TrkA) receptor of NGF in a context of inflammatory joint pain (arthritis), but also of somatic and visceral pain. Since a total knockout of TrkA receptor in mice is not viable, we performed a multimodal study in TrkA/C knock-in mice, expressing a chimeric receptor composed of the native extracellular part of TrkA receptor and, the transmembrane and intracellular functional parts of the neurotrophin 3 receptor: TrkC receptor, which is not really involved in inflammatory pain. Thus, NGF can bind normally to the TrkA/C receptor but activates the intracellular signaling pathways downstream of TrkC receptor. Our results have shown that a lack of activation of certain TrkA pathways (i.e. c-Jun and p38 MAPK) in the DRGs of TrkA/C mice, has a significant impact on the development of painful symptoms, especially mechanical hypersensitivity in a context of articular, somatic, or visceral pain, without affecting heat thermal hyperalgesia. These effects result, on one hand, from the decrease of CGRP+ nerve sprouting and in another hand, from the transcriptional changes of some neurotransmitters and mechanotransducers including the proton-sensitive ion channel: ASIC3. In addition, our studies highlight a direct link between NGF/TrkA and bone remodeling, in particular, osteoclastic activity, suggesting a beneficial role of the inhibition of some specific TrkA-associated pathways, in both mechanical hypersensitivity and bone erosion found in RA.In a second part of our work, we investigated the mechanisms involved in arthralgia induced by the injection of autoantibodies against citrullinated peptides (ACPA). The majority of RA patients is positive for ACPA that can be produced months to years before RA diagnosis and appear to be directly associated with the development of pain. Arthralgia is one of the first signs of an emerging RA and can persist even following RA treatment. First, we confirmed that monoclonal ACPA IgG1 subtypes differ in their pronociceptive and bone erosive properties certainly link to their reactivity patterns against citrullinated epitopes on different targets especially those engaging osteoclast activity. Thus, the combination of B02/B09 ACPA clones induced pain like behaviour without any inflammation, but is associated with an alteration of bone homeostasis in injected mice. We suggest that as a result of ACPA-induced osteoclast activation, certain factors (e.g. protons and/or lipids) are released, which sensitize ASIC3, ultimately leading to pain
Chivard, Didier. "L'injection intraventriculaire de morphine dans les algies rebelles néoplasiques : à propos d'une étude sur 14 malades suivis dans le service de neuro-chirurgie du CHR de Brest de 1983 à 1986." Brest, 1988. http://www.theses.fr/1988BRES3050.
Full textLefevre, Yan. "Rôle de la glie dans la douleur chronique d'origine cancéreuse chez le rat." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22090/document.
Full textThe present work has investigated the role of glia upon pain symptoms in a well established peripheral neuropathic pain model and a bone cancer pain model. The neuropathic pain model was obtained by right L5-L6 spinal nerve ligation in male Wistar rats. Bone cancer pain was induced by injecting MRMT-1 rat mammary gland carcinoma cells into the right tibia of Sprague-Dawley female rats. Mechanical allodynia and hyperalgesia were quantified using von Frey hairs and ambulatory incapacitance using dynamic weight bearing. Drugs were administered either acutely or chronically using osmotic pumps, through intrathecal catheters chronically implanted in experimental animals. Using von Frey hair stimuli, we found that transient inhibition of glia metabolism by intrathecal injection of fluorocitrate was ineffective in both models. In both models, pain symptoms required spinal NMDA receptor activation. Intrathecal administration of a single dose of D-aminoacid oxidase, which degrades D-serine, a co-agonist of NMDA receptors, reduced mechanical allodynia and hyperalgesia in neuropathic rats and allodynia in cancer rats. The effect of chronic fluoroacetate in neuropathic rats was reversed by acutely administered intrathecal D-serine, which had only a slight effect in cancer rats. None of these compounds altered the functional disability shown by neuropathic or cancer animals and measured by the dynamic weight bearing apparatus. These results show that neuropathic pain and cancer pains depend upon D-serine co-activation of spinal NMDA receptors but only neuropathic pain requires functional spinal cord glia in the rat. Glia may thus play different roles in the development and maintenance of chronic pain in these two situations
Schaeffer, Véronique. "Rôle des neurostéroïdes endogènes dans la régulation des processus neurodégénératifs impliqués dans la maladie d'Alzheimer et dans l'étiologie des douleurs neuropathiques." Strasbourg 1, 2007. http://www.theses.fr/2007STR13153.
Full textTransfection of human neuroblastoma SH-SY5Y cells with Alzheimer’s disease key proteins including native hTau40, mutant Tau P301L or APP resulted in neurosteroid biosynthesis dysregulation. HTau40 strongly stimulated neurosteroidogenesis while Tau P301L was devoid of action. Amyloid-β peptides exerted a dose-and sequence-dependent effect on neurosteroidogenesis. H2O2 killed SH-SY5Y cells through inhibition of aromatase gene expression and estradiol (E2) synthesis. Pretreatment with E2 rescued SH-SY5Y cells from H2O2-induced death. Apoptotic satellite glial cells were evidenced in dorsal root ganglia of neuropathic pain rats. E2 production increased in sensory neurons surrounded by apoptotic satellite cells, suggesting that endogenous neurosteroids may control neurodegenerative events in dorsal root ganglia. Together, the data open interesting possibilities for the development of neurosteroid-based neuroprotective strategies
Otis, Valérie. "Rôle du récepteur opioïde delta dans un modèle de douleur cancéreuse." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6348.
Full textEcheverri, Castano Estefania. "Prolifération des cellules gliales dans la moelle épinière et douleur neuropathique." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24980/24980.pdf.
Full textEcheverry, Estefania. "Prolifération des cellules gliales dans la moelle épinière et douleur neuropathique." Master's thesis, Université Laval, 2007. http://hdl.handle.net/20.500.11794/19499.
Full textBarthèlemy, Pierre. "Reflexions sur l'apport du paracetamol dans le traitement de la douleur." Saint-Etienne, 1994. http://www.theses.fr/1994STET6230.
Full textBenbouzid, Malika. "Effets thérapeutiques des antidépresseurs dans un modèle murin de douleur neuropathique." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13120.
Full textGaumond, Isabelle. "Le rôle des hormones sexuelles dans la perception de la douleur chez le rat." Sherbrooke : Université de Sherbrooke, 2002.
Find full textParienté, Francis. "Patient-controlled analgésia (PCA) : place et intérêt dans la prise en charge de la douleur cancéreuse : expérience de son utilisation à la fondation Bergonié." Bordeaux 2, 1993. http://www.theses.fr/1993BOR23067.
Full textDEMARQUAY, JEAN-FRANCOIS. "Physiopathologie et traitements de la douleur dans les pancreatites chroniques : a propos de 100 observations." Nice, 1993. http://www.theses.fr/1993NICE6502.
Full textGervais, Michèle. "Le rôle des médias dans la formation d'enjeux sociaux." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/MQ41909.pdf.
Full textDugas, Amélie. "Promotion des concours de beauté dans les médias sudburois." Acfas-Sudbury, 2007. https://zone.biblio.laurentian.ca/dspace/handle/10219/77.
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