Log in

Relevant bibliographies by topics / Dopegal / Journal articles

Journal articles on the topic 'Dopegal'

To see the other types of publications on this topic, follow the link: Dopegal.

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Dopegal.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kang, Seong Su, Lanxia Meng, Xingyu Zhang, Zhiping Wu, Ariana Mancieri, Boer Xie, Xia Liu, et al. "Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation." Nature Structural & Molecular Biology 29, no. 4 (March 24, 2022): 292–305. http://dx.doi.org/10.1038/s41594-022-00745-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Kang, Seong Su, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P. Manfredsson, Xifei Yang, Hongbo R. Luo, L. Cameron Liles, David Weinshenker, and Keqiang Ye. "Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus." Journal of Clinical Investigation 130, no. 1 (December 3, 2019): 422–37. http://dx.doi.org/10.1172/jci130513.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Wanner, Martin J., Ed Zuidinga, Dorette S. Tromp, Jan Vilím, Steen Ingemann Jørgensen, and Jan H. van Maarseveen. "Synthetic Evidence of the Amadori-Type Alkylation of Biogenic Amines by the Neurotoxic Metabolite Dopegal." Journal of Organic Chemistry 85, no. 2 (December 16, 2019): 1202–7. http://dx.doi.org/10.1021/acs.joc.9b01948.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Burke, William J., Bruce S. Kristal, Byung P. Yu, Shu Wen Li, and Tien-Sung Lin. "Norepinephrine transmitter metabolite generates free radicals and activates mitochondrial permeability transition: a mechanism for DOPEGAL-induced apoptosis." Brain Research 787, no. 2 (March 1998): 328–32. http://dx.doi.org/10.1016/s0006-8993(97)01488-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Burke, W., S. Li, K. Gillespie, H. Chung, K. Jagadeesan, and J. Joist. "Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis." Letters in Drug Design & Discovery 3, no. 7 (September 1, 2006): 481–87. http://dx.doi.org/10.2174/157018006778194880.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kang, Seong Su, Eun Hee Ahn, and Keqiang Ye. "Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease." Experimental & Molecular Medicine 52, no. 8 (August 2020): 1275–87. http://dx.doi.org/10.1038/s12276-020-00494-7.

Full text

Abstract:

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease with age as a major risk factor. AD is the most common dementia with abnormal structures, including extracellular senile plaques and intraneuronal neurofibrillary tangles, as key neuropathologic hallmarks. The early feature of AD pathology is degeneration of the locus coeruleus (LC), which is the main source of norepinephrine (NE) supplying various cortical and subcortical areas that are affected in AD. The spread of Tau deposits is first initiated in the LC and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. Most recently, we reported that the NE metabolite DOPEGAL activates delta-secretase (AEP, asparagine endopeptidase) and triggers pathological Tau aggregation in the LC, providing molecular insight into why LC neurons are selectively vulnerable to developing early Tau pathology and degenerating later in the disease and how δ-secretase mediates the spread of Tau pathology to the rest of the brain. This review summarizes our current understanding of the crucial role of δ-secretase in driving and spreading AD pathologies by cleaving multiple critical players, including APP and Tau, supporting that blockade of δ-secretase may provide an innovative disease-modifying therapeutic strategy for treating AD.

APA, Harvard, Vancouver, ISO, and other styles

7

Li, Shu Wen, Vincent T. Spaziano, William H. Elliott, and William J. Burke. "Synthesis and Use of Deuterated 3,4-Dihydroxyphenylglycolaldehyde as an Internal Standard for Determination of Dopegal in Brain Tissue by Gas Chromatography–Mass Spectrometry." Bioorganic Chemistry 24, no. 2 (June 1996): 169–77. http://dx.doi.org/10.1006/bioo.1996.0015.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Rorie, D. K., L. W. Hunter, and G. M. Tyce. "Dihydroxyphenylglycol as an index of neuronal uptake in dog saphenous vein." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 6 (December 1, 1989): H1945—H1951. http://dx.doi.org/10.1152/ajpheart.1989.257.6.h1945.

Full text

Abstract:

Dihydroxyphenylglycol (DOPEG), the metabolite of norepinephrine (NE) that arises intraneuronally, was measured together with NE in superfusates collected before, during, and after nerve stimulation and in extracts of dog saphenous vein after superfusion and electrical stimulation (ES). Different concentrations of NE in the synaptic clefts were achieved by treating tissues with corticosterone, corticosterone and yohimbine, corticosterone and cocaine, or by omitting drugs from the superfusate. NE and DOPEG were quantitated by liquid chromatography with electrochemical detection. The time courses of NE overflow and DOPEG efflux into superfusate were followed. The amounts of DOPEG in superfusates under basal conditions were two to four times higher than the amounts of NE and progressively increased during ES except in tissues with neuronal uptake inhibited. NE overflow reached a steady state within the first 6 min of ES. Increased NE concentrations in synaptic clefts resulted in increased DOPEG production except where neuronal uptake was inhibited. The increased DOPEG production during ES appears to reflect the increased rate of neuronal uptake, which results in more NE being available for intraneuronal metabolism. No evidence was found that newly formed DOPEG was delayed in leaving the tissue. Thus the increase in DOPEG production that occurs during ES may be useful as an index of neuronal uptake of NE in dog saphenous vein.

APA, Harvard, Vancouver, ISO, and other styles

9

Vaskiv, O. V., A. P. Hryhorenko, O. H. Horbatiuk, L. V. Dudikova, A. S. Shatkovska, and A. N. Binkovska. "Optimization of pharmacotherapy of gestational hypertension." Reports of Vinnytsia National Medical University 26, no. 4 (December 24, 2022): 586–91. http://dx.doi.org/10.31393/reports-vnmedical-2022-26(4)-12.

Full text

Abstract:

Annotation. Hypertension in pregnant women disimprove the placental function, impairs fetal development and has an adverse effect on the condition of a woman. Usually dopegyt is used to treat gestational hypertension. However, it reduces the microcirculation of blood in the placenta, causing or increasing pre-existing placental dysfunction. Therefore, the aim of the research is to optimize the method of gestational hypertension pharmacotherapy in pregnant women with a set of infusion drugs including pentoxifylline, arginine hydrochloride with levocarnitine and reosorbilact to prevent fetoplacental dysfunction and perinatal pathology in this case. We examined 73 pregnant women, among whom we distinguished 3 groups: first group (n = 30) - pregnant women with GH, who, along with the basic therapy with dopegyt received a complex of infusion solutions (pentoxifylline, a solution containing arginine hydrochloride and levocarnitine, drug reosorbilact); second group (n=20) - patients with gestational hypertension who received only basic therapy with dopegyt; control group (n=23) - women with physiological pregnancy. Studies of the clinical effectiveness of the proposed treatment were evaluated by cases of prevention of perinatal pathology (intrauterine growth restriction of the fetus (IUGR), premature birth, etc.) and the results of clinical, laboratory and instrumental research methods. Criteria for inclusion in the study were: the presence of blood pressure ≥150/100 mm Hg, dopegyt, gestational age from 28 to 36 weeks, singleton pregnancy. Examination of pregnant women was performed using standard clinical, laboratory and instrumental (Doppler ultrasounds) research methods. The analysis of the obtained data was performed using the program “STATISTICA 5.5”. Established that in patients who received our treatment regimen, there was a significant reduction in the development of placental dysfunction (OR 0.30, 95 % CI [0.12-0.74], p=0.009), fetal IUGR (OR 0.33, 95 % CI [0.12-0.96], p=0.042), acute fetal distress (OR 0.25, 95 % CI [0.075-0.83], p=0.02), weakness of childbirth (OR 0,19, 95 % CI [0.04-0.82], p=0.03), reducing the risk of perinatal CNS damage (OR 0.22, 95 % CI [0.05-0.99], p=0.049 ) and reducing the risk of cephalohematoma (OR 0.25, 95 % CI [0.075-0.83], p=0.024).

APA, Harvard, Vancouver, ISO, and other styles

10

Russell, J. A., and K. W. Kircher. "Metabolism of norepinephrine during nerve stimulation in dog trachea." Journal of Applied Physiology 59, no. 4 (October 1, 1985): 1236–41. http://dx.doi.org/10.1152/jappl.1985.59.4.1236.

Full text

Abstract:

We determined the relative importance of neuronal and extraneuronal uptake in the metabolism of norepinephrine (NE) released during electrical stimulation (ES) of isolated canine tracheal smooth muscle (TSM). Strips of TSM were labeled with L-[3H]NE (2 X 10(-7) M) and mounted for superfusion. Superfusate was collected continuously before, during, and after ES (15 V, 0.5 ms, 5 Hz). Measurements were made of [3H]NE and its metabolites in superfusate and in tissue. Neuronal uptake followed by metabolism was estimated by measuring the amount of 3,4-dihydroxyphenylglycol (DOPEG). Extraneuronal uptake was estimated by measuring O-methylated metabolites (OMM). ES caused large increases in the efflux of NE, DOPEG, and OMM from TSM. However, the overflow of OMM was six times greater than that of DOPEG. Cocaine (10(-5) M) abolished the increased efflux of DOPEG during ES and enhanced the overflow of NE and OMM. We conclude that extraneuronal uptake constitutes the primary metabolic pathway for NE released from adrenergic nerves innervating TSM.

APA, Harvard, Vancouver, ISO, and other styles

11

Rorie, D. K., L. W. Hunter, and G. M. Tyce. "Neuropeptide Y and 3,4-dihydroxyphenylglycol effluxes from artery are oxygen sensitive." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 5 (November 1, 1991): H1371—H1378. http://dx.doi.org/10.1152/ajpheart.1991.261.5.h1371.

Full text

Abstract:

Neuropeptide Y-like immunoreactivity (NPY-LI), norepinephrine (NE), and 3,4-dihydroxyphenylglycol (DOPEG), the intraneuronal metabolite of NE, were measured in superfusate before, during, and after electrical stimulation (ES) of nerves and in the tissue extract of dog pulmonary artery after in vitro superfusion. Vessels were stimulated at 12, 6, or 1 Hz. NE and DOPEG were quantified by high-performance liquid chromatography with electrochemical detection, NPY-LI by radioimmunoassay. The Krebs-Ringer superfusate was maintained at a partial pressure of oxygen of either 472, 100, 50, or 20 mmHg. Mean DOPEG efflux was 0.17, 0.15, 0.13, and 0.07 pmol/min during basal conditions and 0.73, 0.39, 0.30, and 0.15 pmol/min, respectively, during 12-Hz continuous stimulation using these four oxygen pressures. Stimulation-evoked efflux of NPY-LI was 1.5, 1.1, 0.3, and 0.2 fmol/min during 12-Hz stimulation. These studies provide evidence that the production and subsequent efflux of DOPEG into superfusate under resting conditions, during ES, and following ES are oxygen sensitive. Additionally, the efflux of NPY-LI from dog pulmonary artery resulting from high frequencies of ES is oxygen sensitive.

APA, Harvard, Vancouver, ISO, and other styles

12

Ryan, D. H., J. M. Cadogan, and J. van Lierop. "Transverse spin freezing in ruthenium-dopeda−Fe90Zr10." Physical Review B 62, no. 13 (October 1, 2000): 8638–41. http://dx.doi.org/10.1103/physrevb.62.8638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Wiarda, D., and D. H. Ryan. "Relaxation and spin correlations in119Sn‐dopeda‐Fe90Sc10." Journal of Applied Physics 76, no. 10 (November 15, 1994): 6189–91. http://dx.doi.org/10.1063/1.358346.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Chahine, R., R. Nadeau, D. Lamontagne, N. Yamaguchi, and J. de Champlain. "Norepinephrine and dihydroxyphenylglycol effluxes from sympathetic nerve endings during hypoxia and reoxygenation in the isolated rat heart." Canadian Journal of Physiology and Pharmacology 72, no. 6 (June 1, 1994): 595–601. http://dx.doi.org/10.1139/y94-085.

Full text

Abstract:

The present experiments were carried out in isolated rat hearts perfused according to the Langendorff method at a constant pressure of 10 kPa. The aim was to measure norepinephrine (NE) overflow and its deaminated metabolite dihydroxyphenyl-glycol (DOPEG) by changing the composition of the buffer perfusing the heart to simulate hypoxia. When aerobic and glycolytic pathways were simultaneously reduced, NE and DOPEG overflow increased 711 and 145%, respectively, after 30 min, compared with control values of 0.45 ± 0.06 and 0.66 ± 0.7 ng∙min−1∙g−1 of heart (n = 8, p < 0.05). Whereas NE leakage decreased sharply after reoxygenation and glucose addition, DOPEG continued to increase up to 260% after 5 min of normal reperfusion. This mechanism was calcium independent and inhibited by 80% with desipramine (1 μM), confirming the role of the uptake I carrier, which reversed its normal transport direction. Neuropeptide Y, a marker of exocytotic release, did not increase in the perfusate with the progression of hypoxia, which supports the hypothesis of a nonexocytotic release. Tyramine (1 μM) significantly enhanced NE outflow by displacing the amine from its storage vesicles through a calcium-independent mechanism, indicating that a pool of NE was still available. In the presence of 1 μM clorgyline (a monoamine oxidase A inhibitor) but not deprenyl (a monoamine oxidase B inhibitor), NE outflow increased 934% and DOPEG only 40% at 30 min (n = 6, p < 0.05 versus control hearts). It is concluded that both oxygen and glucose deprivation are necessary to induce a significant NE release from cardiac sympathetic nerve terminals and mat monoamine oxidase A plays a principal role in NE deamination during hypoxia.Key words: heart, norepinephrine, hypoxia, monoamine oxidase, uptake I carrier.

APA, Harvard, Vancouver, ISO, and other styles

15

Takada, J., and H. Fritzsche. "Drift mobility of dopeda-Si:H at high temperatures." Physical Review B 36, no. 3 (July 15, 1987): 1710–14. http://dx.doi.org/10.1103/physrevb.36.1710.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Winer, K., I. Hirabayashi, and L. Ley. "Exponential Conduction-Band Tail in P-Dopeda−Si:H." Physical Review Letters 60, no. 25 (June 20, 1988): 2697–700. http://dx.doi.org/10.1103/physrevlett.60.2697.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Alexander, N., and M. Morris. "Effects of chronic sinoaortic denervation on central vasopressin and catecholamine systems." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 255, no. 5 (November 1, 1988): R768—R773. http://dx.doi.org/10.1152/ajpregu.1988.255.5.r768.

Full text

Abstract:

The objective of this study was to determine whether chronic arterial baroreceptor deficit induces time-related changes in central vasopressin (AVP) and catecholamine systems. Groups of sinoaortic-denervated (SAD) and sham-operated (SO) rats were studied 1, 3, 4, 7, and 14 days after surgery. Supraoptic (SON), paraventricular (PVN) and arcuate (ARC) nuclei, median eminence (ME) region, and A1 region of medulla were obtained by micropunch from frozen brain sections and assayed for AVP, tyrosine hydroxylase (TH) activity, catecholamines, and their metabolites, dihydroxyphenylethyleneglycol (DOPEG) and 2,5-dihydroxyphenylacetic acid (DOPAC). AVP concentration in SON and PVN was increased in 1-day-SAD rats, reduced in 3- and 4-day-SAD rats, equal and above control values in 7- and 14-day-SAD rats, respectively. TH activity was increased in SON and reduced in ME and ARC of 1- and 7-day-SAD rats. In SON, DOPEG was increased, whereas in ME all catecholamines and DOPEG and DOPAC were reduced in 1-day-SAD rats. ME catecholamines returned toward control levels in 3- to 4-day-SAD rats. These studies show that the chronic absence of arterial baroreceptor input produces time-related, regionally specific central changes of vasopressin and regionally associated catecholamines.

APA, Harvard, Vancouver, ISO, and other styles

18

WEI, LI-HUA, SHAO-YI WU, ZHI-HONG ZHANG, HUI WANG, and XUE-FENG WANG. "INVESTIGATIONS ON THE LOCAL STRUCTURE AND THE EPR PARAMETERS FORCu2+-DOPEDGaN." Modern Physics Letters B 22, no. 18 (July 20, 2008): 1739–47. http://dx.doi.org/10.1142/s0217984908016431.

Full text

Abstract:

The local structure and the EPR parameters (g factors and the hyperfine structure constants) for Cu2+in GaN are theoretically studied from the perturbation formulas of these parameters for a 3d9ion in trigonally distorted tetrahedra. In these formulas, the ligand orbital and spin-orbit coupling contributions are taken into account from the cluster approach, in view of the strong covalency effect of the system. Based on the studies, the impurity Cu2+is found not to occupy exactly the host Ga3+site but to suffer a slight displacement (≈ 0.004 Å ) towards the ligand triangle along C3axis due to charge and size mismatching substitution. The theoretical EPR parameters show good agreement with the experimental data. The validity of the impurity displacement is also discussed.

APA, Harvard, Vancouver, ISO, and other styles

19

Kegel, Philipp, Michel Steuwer, and Sergei Gorlatch. "dOpenCL: Towards uniform programming of distributed heterogeneous multi-/many-core systems." Journal of Parallel and Distributed Computing 73, no. 12 (December 2013): 1639–48. http://dx.doi.org/10.1016/j.jpdc.2013.07.021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Jousse, D., E. Bustarret, A. Deneuville, and J. P. Stoquert. "rf-sputtered B-dopeda-Si:H anda-Si-B-H alloys." Physical Review B 34, no. 10 (November 15, 1986): 7031–44. http://dx.doi.org/10.1103/physrevb.34.7031.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Fajardo, F., and I. Chambouleyron. "Structural and optoelectronic properties of indium-dopeda-Ge:H thin films." Physical Review B 52, no. 7 (August 15, 1995): 4965–73. http://dx.doi.org/10.1103/physrevb.52.4965.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Song, Keun Man, Chang Zoo Kim, Jong Min Kim, Dae Ho Yoon, Sung Min Hwang, and Hogyoung Kim. "Properties of Si-Dopeda-Plane GaN Grown with Different SiH4Flow Rates." Japanese Journal of Applied Physics 50, no. 5R (May 1, 2011): 055502. http://dx.doi.org/10.7567/jjap.50.055502.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bisaro, R., J. Magario, K. Zellama, S. Squelard, P. Germain, and J. F. Morhange. "Solid-phase crystallization kinetics in dopeda-Si chemical-vapor-deposition films." Physical Review B 31, no. 6 (March 15, 1985): 3568–75. http://dx.doi.org/10.1103/physrevb.31.3568.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Song, Keun Man, Chang Zoo Kim, Jong Min Kim, Dae Ho Yoon, Sung Min Hwang, and Hogyoung Kim. "Properties of Si-Dopeda-Plane GaN Grown with Different SiH4Flow Rates." Japanese Journal of Applied Physics 50, no. 5 (May 20, 2011): 055502. http://dx.doi.org/10.1143/jjap.50.055502.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Babras, Suvarna, V. G. Bhide, N. R. Rajopadhye, and S. V. Bhoraskar. "Defect creation by 10‐keV electron irradiation in phosphorous‐dopeda‐Si:H." Journal of Applied Physics 67, no. 6 (March 15, 1990): 2800–2805. http://dx.doi.org/10.1063/1.345446.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Chen, L., J. Tauc, J. Kočka, and J. Stuchlík. "Metastable states in undoped and dopeda-Si:H studied by photomodulation spectroscopy." Physical Review B 46, no. 4 (July 15, 1992): 2050–60. http://dx.doi.org/10.1103/physrevb.46.2050.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Tajima, M., H. Okushi, S. Yamasaki, and K. Tanaka. "Strong electron-phonon coupling in defect luminescence in P-dopeda-Si:H." Physical Review B 33, no. 12 (June 15, 1986): 8522–24. http://dx.doi.org/10.1103/physrevb.33.8522.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Cargill, G. S., A. Segmüller, T. F. Kuech, and T. N. Theis. "Lattice strain fromDXcenters and persistent photocarriers in Sn-doped and Si-dopedGa1−xAlxAs." Physical Review B 46, no. 16 (October 15, 1992): 10078–85. http://dx.doi.org/10.1103/physrevb.46.10078.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Buyanov, A. V., J. P. Bergman, J. A. Sandberg, B. E. Sernelius, P. O. Holtz, B. Monemar, H. Amano, and I. Akasaki. "Influence of potential fluctuations on electrical transport and optical properties in modulation-dopedGaN/Al0.28Ga0.72Nheterostructures." Physical Review B 58, no. 3 (July 15, 1998): 1442–50. http://dx.doi.org/10.1103/physrevb.58.1442.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Deng, X. M., and H. Fritzsche. "Light-induced perturbation of the high-temperature equilibrium in phosphorus-dopeda-Si: H." Physical Review B 36, no. 17 (December 15, 1987): 9378–80. http://dx.doi.org/10.1103/physrevb.36.9378.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Boudreau, N. J., and M. M. Vohra. "The mechanism of [3H]noradrenaline release by histamine and its analogs from the rat vas deferens." Canadian Journal of Physiology and Pharmacology 69, no. 4 (April 1, 1991): 469–74. http://dx.doi.org/10.1139/y91-070.

Full text

Abstract:

In this study the mechanism by which histamine and H1 and H2 agonists evoked an overflow of radioactivity from rat vasa deferentia preloaded with [3H]noradrenaline was investigated. The overflow evoked by the various agonists was unaffected by the presence of such receptor antagonists as propranolol, phentolamine, cimetidine, or scopolamine. On the other hand, the overflow evoked by all agonists except dimaprit was inhibited by mepyramine and by two well-known neuronal uptake inhibitors, cocaine and desipramine. The inhibition by mepyramine has been attributed to its effect on the neuronal uptake process. Metabolic profile studies showed that 3,4-dihydroxyphenylglycol (DOPEG) was the major constituent in the evoked overflow caused by histamine, 2-methylhistamine, 4-methylhistamine, and dimaprit and that the overflow evoked by 2-pyridylethylamine and 2-thiazolylethylamine consisted predominantly of unchanged noradrenaline. Based on these findings, it is concluded that all of the agonists tested evoke noradrenaline release intraneuronally by entering the adrenergic nerve terminals. While dimaprit might enter by passively diffusing into the adrenergic nerves, other agonists seem to use the neuronal uptake process. Noradrenaline released intraneuronally is subsequently degraded by neuronal monoamine oxidase to form DOPEG. However, there are qualitative and quantitative differences in the metabolic profile of the overflow evoked by various agonists. It is suggested that these differences could arise from their additional properties, such as their effect on the neuronal uptake process and (or) their ability to act as substrate for neuronal monoamine oxidase.Key words: noradrenaline, vas deferens, histamine, histamine H1 and H2 agonists.

APA, Harvard, Vancouver, ISO, and other styles

32

Christman, J. V., and C. V. Gisolfi. "Heat acclimation: role of norepinephrine in the anterior hypothalamus." Journal of Applied Physiology 58, no. 6 (June 1, 1985): 1923–28. http://dx.doi.org/10.1152/jappl.1985.58.6.1923.

Full text

Abstract:

The hypothesis that anterior hypothalamic (AH) sensitivity to norepinephrine (NE) is altered by chronic exercise in the heat was tested in male Sprague-Dawley rats. Treadmill exercise 6 days/wk for 3 wk at 21 m/min was performed at 23 degrees C (control; C) or at 35 degrees C (heat acclimated; HA), progressing from 20 to 50 min/day in 2 wk. Time for core temperature (Tco) to rise from 39.5 to 40.5 degrees C during a heat-tolerance test after conditioning increased (P less than 0.05) in the HA group. To test for a change in AH sensitivity, the change in Tco to 2-, 5-, 10-, 20-, and 40-micrograms doses of NE injected bilaterally into the AH was determined after conditioning. Dose-response regression lines showed that exercise in the heat increased the slope and shifted the Tco-NE dose relation to the left. In a separate series of experiments on 6 sedentary(s), 10 C, and 10 HA animals, the amounts of NE, dopamine, and 3,4-dihydroxyphenylglycol (DOPEG) were determined by high-pressure liquid chromatography in the AH, median preoptic area (PO), cortex, and cerebellum after 9 wk of conditioning. Results showed that in the PO there was a significant increase in NE and DOPEG in the HA vs. C group and a trend of increasing NE from the S to C to HA groups. The data indicate that exercise in the heat increases NE-induced peripheral heat-dissipating capacity and increases catecholamine storage in the PO.

APA, Harvard, Vancouver, ISO, and other styles

33

(Aceprensa), J. D. "JOSÉ MIGUEL PERO-SANZ, Iglesia en tiempo de crisis, 164 págs. Dopesa, Barcelona, 1975." Ius Canonicum 15, no. 30 (March 27, 2018): 386–87. http://dx.doi.org/10.15581/016.15.21272.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Sakai, Yuichi, Michio Matsumura, Yoshihiro Nakato, and Hiroshi Tsubomura. "Effect of metal/P‐dopeda‐Si:H junctions on the photovoltage ofa‐Si:H solar cells." Journal of Applied Physics 62, no. 8 (October 15, 1987): 3424–26. http://dx.doi.org/10.1063/1.339306.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Shane, J. J., P. A. A. W. van der Heijden, E. J. Reijerse, and E. de Boer. "An ESEEM investigation of single crystals and powders of copper-dopedl-histidine hydrochloride monohydrate." Applied Magnetic Resonance 6, no. 3 (April 1994): 427–54. http://dx.doi.org/10.1007/bf03162635.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Kessler, B., A. Bringer, S. Cramm, C. Schlebusch, W. Eberhardt, S. Suzuki, Y. Achiba, F. Esch, M. Barnaba, and D. Cocco. "Evidence for Incomplete Charge Transfer and La-Derived States in the Valence Bands of Endohedrally DopedLa@C82." Physical Review Letters 79, no. 12 (September 22, 1997): 2289–92. http://dx.doi.org/10.1103/physrevlett.79.2289.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Mitra, S., R. Shinar, and J. Shinar. "Evidence for structural relaxation in measurements of hydrogen diffusion in rf-sputtered boron-dopeda-Si:H." Physical Review B 42, no. 10 (October 1, 1990): 6746–49. http://dx.doi.org/10.1103/physrevb.42.6746.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Takada, J., and H. Fritzsche. "Photoinduced change in the density of localized states near the conduction band of dopeda-Si:H." Physical Review B 36, no. 3 (July 15, 1987): 1706–9. http://dx.doi.org/10.1103/physrevb.36.1706.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Wang, Zhi-Jun, Pan-Lai Li, Zhi-Ping Yang, and Qing-Lin Guo. "Improving luminescent property of SrIn2O4:Eu3+by co-dopedA+(A= Li, Na, K) or Sm3+." Chinese Physics B 22, no. 4 (April 2013): 047804. http://dx.doi.org/10.1088/1674-1056/22/4/047804.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Ferre, R., A. Orpella, D. Munoz, I. Martín, F. Recart, C. Voz, J. Puigdollers, P. Roca i. Cabarrocas, and R. Alcubilla. "Very low surface recombination velocity of crystalline silicon passivated by phosphorus-dopeda-SicxNy:H(n) alloys." Progress in Photovoltaics: Research and Applications 16, no. 2 (2008): 123–27. http://dx.doi.org/10.1002/pip.802.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Lala, S., M. Ghosh, P. K. Das, D. Das, T. Kar, and S. K. Pradhan. "Structural and microstructural interpretations of Zn-doped biocompatible bone-like carbonated hydroxyapatite synthesized by mechanical alloying." Journal of Applied Crystallography 48, no. 1 (January 30, 2015): 138–48. http://dx.doi.org/10.1107/s1600576714026119.

Full text

Abstract:

Single-phase nanocrystalline biocompatible Zn-dopedA-type carbonated hydroxyapatite (A-cHAp) powder has been synthesizedviamechanical alloying of a stoichiometric mixture of CaCO3, CaHPO4·2H2O and ZnO powders in open air at room temperature by 10 h of milling. TheA-type carbonation in HAp (A-cHAp) is confirmed by Fourier transform IR analysis. The structural and microstructural parameters of the as-milled powders are revealed by Rietveld powder structure refinement analysis and transmission electron microscopy. Zn substitution along with mechanical alloying causes partial amorphization of crystallineA-cHAp, analogous to native bone mineral. Zn2+cations substitute into the ninefold-coordinated Ca2+sites in theA-cHAp unit cell. An assay test using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] reveals a high percentage of cell viability and hence confirms the biocompatibility of the sample. The overall results indicate that the processedA-cHAp has a chemical composition very close to that of natural biological apatite.

APA, Harvard, Vancouver, ISO, and other styles

42

Kakinuma, H., M. Mohri, M. Sakamoto, and H. Sawai. "Gap-state density of lightly P- and B-dopeda-Si:H deduced from space-charge-limited photocurrents." Physical Review B 43, no. 6 (February 15, 1991): 4871–78. http://dx.doi.org/10.1103/physrevb.43.4871.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Rajendran, V., and S. Gnanam. "Growth and Characterization of Co-DopedL-Lysine Monohydrochloride Dihydrate (CLMHCl) Single Crystals by Slow Evaporation Method." E-Journal of Chemistry 9, no. 2 (2012): 563–68. http://dx.doi.org/10.1155/2012/583080.

Full text

Abstract:

Single crystal of Cobalt doped L-Lysine monohydrochloride dihyrate (CLMHCl) was grown by slow evaporation technique from its aqueous solution. The effects of Co-doping on the growth, structural, and optical properties of CLMHCl crystal have been investigated. To grow good quality crystals pH value of growth solution has been optimized and solubility of CLMHCl values was determined. The cell parameters are verified by single crystal X-ray Diffraction. Fourier transform infrared spectum (FT-IR) is used to confirm the presence of various functional groups in the grown crystal. The presence of Co in the grown crystal was confirmed by Inductively-coupled plasma (ICP) elemental analysis. The optical transmission study shows that the CLMHCl crystal has good optical transparency in the UV and visible regions.

APA, Harvard, Vancouver, ISO, and other styles

44

Guerra, J. Andres, Felix Benz, A. Ricardo Zanatta, Horst P. Strunk, Albrecht Winnacker, and Roland Weingärtner. "Concentration quenching and thermal activation of the luminescence from terbium-dopeda-SiC:H andc-AlN thin films." physica status solidi (c) 10, no. 1 (November 29, 2012): 68–71. http://dx.doi.org/10.1002/pssc.201200394.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Lôo, Henri, Trevor Dennis, Jean-Marie Vanelle, Liliane Rouquier, Marie-France Poirier-Littré, Martine Garreau, Chawki Benkelfat, Daniel Sechter, and Bernard Scatton. "Lack of correlation between plasma DOPEG and urinary MOPEG levels in depressed patients." Biological Psychiatry 21, no. 10 (August 1986): 900–906. http://dx.doi.org/10.1016/0006-3223(86)90263-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Thamm, A., O. Brandt, J. Ringling, A. Trampert, K. H. Ploog, O. Mayrock, H. J. Wünsche, and F. Henneberger. "Optical properties of heavily dopedGaN/(Al,Ga)Nmultiple quantum wells grown on6H−SiC(0001)by reactive molecular-beam epitaxy." Physical Review B 61, no. 23 (June 15, 2000): 16025–28. http://dx.doi.org/10.1103/physrevb.61.16025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Cann-Moisan, C., J. Caroff, P. Le Bras, E. Girin, O. Curet, and J. M. Gandon. "Measurement of 3,4 Dihydroxyphenyl Ethylene Glycol (DOPEG) in Plasma by High Performance Liquid Chromatography with Electrochemical Detection." Journal of Liquid Chromatography & Related Technologies 19, no. 19 (November 1996): 3119–24. http://dx.doi.org/10.1080/10826079608015811.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Antsiferova, O. E., M. P. Teleshchenko, Yu M. Tsuverkalova, M. V. Pokrovsky, V. V. Gureev, M. A. Zatolokina, and A. V. Gureeva. "CORRECTION OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PREECLAMPSY BY COMBINED USE OF TRIMETAZIDINE AND PURIFIED MICRONIZED FLAVONOID FRACTION AS WELL AS THEIR COMBINATIONS WITH METHYLAMPSY." Pharmacy & Pharmacology 8, no. 5 (March 2, 2021): 304–15. http://dx.doi.org/10.19163/2307-9266-2020-8-5-304-315.

Full text

Abstract:

The aim of the experiment was to determine the effectiveness of the combined use of trimetazidine and a purified micronized flavonoid fraction, as well as their combinations with methyldopa, in comparison with monotherapy with the same drugs in the correction of morphofunctional disorders arising in the conditions of experimental preeclampsia. An integrated/multimethodology approach is the most effective way of treatment for preeclampsia. Therefore, an urgent task of modern pharmacology is to study the effectiveness of new drugs when used in combinations, as well as the drugs included in the standards for treatment.Materials and methods. The study was carried out at the Research Institute of Pharmacology of Living Systems of Belgorod State National Research University. The experiment was performed on 200 female Wistar rats, weighing 250–300 g, in which an ADMA-like model of preeclampsia had been reproduced. To assess the degree of correction of emerging morphological and functional disorders, the following parameters were involved: blood pressure, a coefficient of endothelial dysfunction, microcirculation in the placenta, proteinuria, fluid contents in the greater omentum, morphometric indicators of placental tissues and fetal height and weight parameters.Results. The combined use of trimetazidine (Preductal® MB) 6 mg/kg and a purified micronized flavonoid fraction (Detralex®) 260 mg/kg, as well as their combination with methyldopa (Dopegit®) 86 mg/kg, leads to a more pronounced decrease in the blood pressure, compared with a decrease in the coefficient of endothelial dysfunction by 2.22, 2.19 and 1.94 times, respectively, in relation to “untreated” animals. There was an increase in microcirculation indices in the placenta by 2.35, 2.21 and 2.03 times, respectively. In addition, there was an improvement in morphological parameters in the placenta and fetuses.Conclusion. The results of the study showed a greater effectiveness of the combined use of the studied drugs in experimental preeclampsia compared to their monotherapy. This indicates the prospects for the use of trimetazidine and purified micronized flavonoid fraction in the complex therapy for preeclampsia and the need for further research in this direction.

APA, Harvard, Vancouver, ISO, and other styles

49

Borges, Nuno, Fátima Martel, Domingas Branco, and Walter Osswald. "Effects of nebivolol stereoisomers on the action of adrenaline on blood pressure, heart rate and blood levels of noradrenaline and DOPEG." Journal of Autonomic Pharmacology 12, no. 6 (December 1992): 429–35. http://dx.doi.org/10.1111/j.1474-8673.1992.tb00391.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Duncan, Richard P., and Jim R. Young. "DETERMINANTS OF PLANT EXTINCTION AND RARITY 145 YEARS AFTER EUROPEAN SETTLEMENT OF AUCKLAND, NEW ZEALAND." Ecology 81, no. 11 (November 2000): 3048–61. http://dx.doi.org/10.1890/0012-9658(2000)081[3048:dopear]2.0.co;2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!